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Food and Chemical Toxicology

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https://www.readbyqxmd.com/read/29787850/rifm-fragrance-ingredient-safety-assessment-2-methyl-trans-2-butenoic-acid-cas-registry-number-80-59-1
#1
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
May 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29787849/application-of-prickly-pear-fruit-extract-to-improve-domestic-shelf-life-quality-and-microbial-safety-of-sliced-beef
#2
Rosa Palmeri, Lucia Parafati, Cristina Restuccia, Biagio Fallico
The research aimed to expand the knowledge on the use of natural bioactive compounds for food preservation. First-crop fruit of prickly pear were subjected to water extraction and evaluated for total polyphenol content, antioxidant activity, in vitro antimicrobial performance against food spoilage and pathogenic bacteria, and betacyanin and betaxanthin content. The extract was then applied by dipping technique to packed sliced beef, to evaluate its effect on physical and chemical parameters, color and texture maintenance, as well as on microbial growth during shelf life at domestic storage conditions...
May 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29787848/effects-of-steaming-on-contaminants-of-emerging-concern-levels-in-seafood
#3
Vera Barbosa, Ana Luísa Maulvault, Ricardo N Alves, Christian Kwadijk, Michiel Kotterman, Alice Tediosi, Margarita Fernández Tejedor, Jens J Sloth, Kit Granby, Rie R Rasmussen, Johan Robbens, Bavo De Witte, Laura Trabalón, José O Fernandes, Sara Cunha, António Marques
Seafood consumption is a major route for human exposure to environmental contaminants of emerging concern (CeCs). However, toxicological information about the presence of CeCs in seafood is still insufficient, especially considering the effect of cooking procedures on contaminant levels. This study is one among a few who evaluated the effect of steaming on the levels of different CeCs (toxic elements, PFCs, PAHs, musk fragrances and UV-filters) in commercially relevant seafood in Europe, and estimate the potential risks associated with its consumption for consumers...
May 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29787847/leaves-and-stem-bark-from-allophylus-africanus-p-beauv-an-approach-to-anti-inflammatory-properties-and-characterization-of-their-flavonoid-profile
#4
Federico Ferreres, Nelson G M Gomes, Patrícia Valentão, David M Pereira, Angel Gil-Izquierdo, Luísa Araújo, Tânia C Silva, Paula B Andrade
The small tree Allophylus africanus, widespread in the African continent, has long been considered valuable, as noted by the number of reports on their multiple medicinal uses. With this work, we aimed to extend the current, and so far restricted, knowledge on the chemical composition of the plant, particularly as source of flavonoids, as well as to assess its potential anti-inflammatory properties. The chemical characterization of the aqueous extract obtained from the leaves allowed the identification and quantitation of 30 flavones, predominantly apigenin derivatives, but also four luteolin derivatives, while the stem bark extract was solely characterized by apigenin di-C-glycosides and mono-C-glycosides-O-glycosylated...
May 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29787846/chemical-study-antioxidant-anti-hypertensive-and-cytotoxic-cytoprotective-activities-of-centaurea-cyanus-l-petals-aqueous-extract
#5
Graziela Bragueto Escher, Jânio Sousa Santos, Neiva Deliberali Rosso, Mariza Boscacci Marques, Luciana Azevedo, Mariana Araújo Vieira do Carmo, Heitor Daguer, Luciano Molognoni, Leonardo do Prado-Silva, Anderson Souza Sant'Ana, Marcia Cristina da Silva, Daniel Granato
This study aimed to optimise the experimental conditions of extraction of the phytochemical compounds and functional properties of Centaurea cyanus petals. The following parameters were determined: the chemical composition (LC-ESI-MS/MS), the effects of pH on the stability and antioxidant activity of anthocyanins, the inhibition of lipid peroxidation, antioxidant activity, anti-hemolytic activity, antimicrobial, anti-hypertensive, and cytotoxic/cytoprotective effect, and the measurements of intracellular reactive oxygen species...
May 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29782898/incorporation-of-absorption-and-metabolism-into-liver-toxicity-prediction-for-phytochemicals-a-tiered-in-silico-qsar-approach
#6
Yitong Liu
An increased use of herbal dietary supplements has been associated with adverse liver effects such as elevated serum enzymes and liver failure. The safety assessment for herbal dietary supplements is challenging since they often contain complex mixtures of phytochemicals, most of which have unknown pharmacokinetic and toxicological properties. Rapid tools are needed to evaluate large numbers of phytochemicals for potential liver toxicity. The current study demonstrates a tiered approach combining identification of phytochemicals in liver toxic botanicals, followed by in silico quantitative structure-activity relationship (QSAR) evaluation of these phytochemicals for absorption (e...
May 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29782897/metal-concentrations-in-fillet-and-gill-of-parrotfish-scarus-ghobban-from-the-persian-gulf-and-implications-for-human-health
#7
Yadolah Fakhri, Narottam Saha, Ali Miri, Aziz Rahimizadeh, Laleh Roomiani, Mansour Ghaderpoori, Mahmoud Taghavi, Hassan Keramati, Zohreh Bahmani, Bigard Moradi, Nazak Amanidaz
Despite the benefits of seafood's consumption, the bioaccumulation of metals in fish can endanger consumers' health. This study analyzed lead (Pb), mercury (Hg), Arsenic (As), and Cadmium (Cd) concentrations in fillet and gill of parrotfish (Scarus ghobban) using flame atomic adsorption spectroscopy (FAAS). The potential non-carcinogenic and carcinogenic health risks due to consumption of Scarus ghobban fillet were assessed by estimating average target hazard quotient (THQ) and total target hazard quotient (TTHQ) and Incremental Lifetime Cancer Risk cancer risk (ILCR) of the analyzed metals...
May 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29778497/food-groups-for-allergen-risk-assessment-combining-food-consumption-data-from-different-countries-in-europe
#8
Sophie Birot, Charlotte B Madsen, Astrid G Kruizinga, Amélie Crépet, Tue Christensen, Per B Brockhoff
To prevent allergic reactions, food producers have to be able to make a knowledge based decision on whether to label their products with precautionary labelling. As many manufactured food products are sold in different countries across Europe, the allergen risk assessment should be estimated at the European levels. As currently, there are no pan-European food data suitable for food allergy risk assessment. The aim of this paper is to investigate if consumption data, at a meal level, from National Food Consumption Surveys, can be combined to form a common Food Consumption database...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29778496/ascorbic-acid-co-administered-with-rosuvastatin-reduces-reproductive-impairment-in-the-male-offspring-from-male-rats-exposed-to-the-statin-at-pre-puberty
#9
Gabriel Adan Araújo Leite, Thamiris Moreira Figueiredo, Marina Trevizan Guerra, Cibele Dos Santos Borges, Fábio Henrique Fernandes, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid by gavage from post-natal day (PND)23 until PND53...
May 17, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29777719/purification-and-identification-of-an-actinomycin-d-analogue-from-actinomycetes-associated-with-ganoderma-applanatum-via-magnetic-molecularly-imprinted-polymers-and-tandem-mass-spectrometry
#10
Chang-Gen Li, Bo Yuan, Meng-Meng Dong, Pin-Yu Zhou, Yu-Xin Hao, Ying-Ying Sun, Meng-Ke Xu, Dan Li, Guo-Yin Kai, Ji-Hong Jiang
Actinomycetes are main producers of antibiotics and targeted screening could improve the efficiency of discovering new drugs. This study describes, for the first time, the isolation of endophytic actinomycetes from the macrofungus Ganoderma applanatum. To increase the efficiency of screening, novel actinomycin D (Act D) molecularly-imprinted polymers were adsorbed to the surface of Fe3 O4 @SiO2 magnetic microspheres (MMIPs) and using in the isolation. A monolithic column prepared with magnetic molecularly imprinted polymers was employed to adsorb actinomycin D and its analogues for selective analysis and identification via MS/MS spectroscopy...
May 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29772268/determination-and-regulation-of-hepatotoxic-pyrrolizidine-alkaloids-in-food-a-critical-review-of-recent-research
#11
Chuanhui Ma, Yang Liu, Lin Zhu, Hong Ji, Xun Song, Hui Guo, Tao Yi
Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans. To date, over 10,000 PAs poisoning cases have been reported worldwide. In recent years, many articles have reported the detection of PAs in various foods, including honey, milk, meat, eggs, tea and salad. This review summarized the contamination of PAs in foods, state of the art detection methods and regulations by different countries and authorities, hoping to propose effective solutions to minimize the consumption of PAs in food...
May 14, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29772267/reactive-oxygen-species-independent-genotoxicity-of-indium-tin-oxide-nanoparticles-triggered-by-intracellular-degradation
#12
Yosuke Tabei, Sakiko Sugino, Yoshihiro Nakajima, Masanori Horie
No abstract text is available yet for this article.
May 14, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29763682/melatonin-attenuates-arsenic-induced-nephropathy-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades-in-mice
#13
Sayanta Dutta, Sukanya Saha, Sushweta Mahalanobish, Pritam Sadhukhan, Parames C Sil
Arsenic is a potent inducer of several acute and chronic nephrotoxic disorders. It promotes deleterious phenomenon like oxidative stress, inflammation, cell death and altered glucose uptake leading to distorted kidney homeostasis that end up in chronic kidney disease. This study investigated the possible protective role of melatonin; a natural antioxidant produced by the pineal gland, against arsenic induced nephrotoxicity. Melatonin successfully ameliorated arsenic induced renal toxicity both in in vitro and in vivo models...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29763681/manuka-honey-attenuates-oxidative-damage-induced-by-h-2-o-2-in-human-whole-blood-in-vitro
#14
Lada Živković, Vladan Bajić, Dragana Dekanski, Andrea Čabarkapa-Pirković, Francesca Giampieri, Massimiliano Gasparrini, Luca Mazzoni, Biljana Spremo Potparević
Manuka honey has been widely researched regarding its biological properties, in particular its antimicrobial and antioxidant capacities. We tested the genotoxic and genoprotective properties of Manuka honey, ranging from 25-1000 μg/mL, by performing an in vitro comet assay after exposure to human whole blood. No genotoxic effect on whole blood cells was observed within the tested concentration range (p = 0.154). Then, the antigenotoxic potency of Manuka honey against oxidative DNA damage to whole blood cells was assessed...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29763680/risk-assessment-of-fluoroquinolones-from-poultry-muscle-consumption-comparing-healthy-adult-and-pre-school-populations
#15
André M P T Pereira, Liliana J G Silva, Jéssica Rodrigues, Celeste Lino, Angelina Pena
Antibiotics, especially fluoroquinolones (FQs), have been largely used in animal husbandry namely poultry production. Therefore, this study aimed to identify, quantify and estimate the daily intake for adult and 3-year-old populations of the FQs norfloxacin (NOR), ciprofloxacin (CIP) and enrofloxacin (ENR) through poultry muscle consumption. The results showed detection frequencies of 78% and 62% in supermarket and school canteen samples, respectively. Of the 182 analysed samples, 4 did not comply with ENR maximum residue level (MRL), and 9 were contaminated with NOR, not allowed as a veterinary medicine of food-producing animals...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29763679/maternal-dietary-nitrate-intake-and-risk-of-neural-tube-defects-a-systematic-review-and-dose-response-meta-analysis
#16
REVIEW
Nader Rahimi Kakavandi, Amin Hasanvand, Mahmoud Ghazi-Khansari, Ahmad Habibian Sezavar, Hassan Nabizadeh, Mohammad Parohan
Despite growing evidence for the potential teratogenicity of nitrate, knowledge about the dose-response relationship of dietary nitrate intake and risk of specific birth defects such as neural tube defects (NTDs) is limited. Therefore, the aim of this meta-analysis was to synthesize the knowledge about the dose-response relation between maternal dietary nitrate intake and the risk of NTDs. We conducted a systematic search in PubMed, ISI Web of Science and Scopus up to February 2018 for observational studies...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29758315/ameliorative-role-of-ferulic-acid-against-diabetes-associated-oxidative-stress-induced-spleen-damage
#17
Sumit Ghosh, Sayantani Chowdhury, Poulami Sarkar, Parames C Sil
Spleen, a secondary lymphoid organ, is the site of initiation of most of the immune responses. The present study is centered on the ameliorative role of ferulic acid against diabetic complications in the spleen of male wistar rats. Induction of diabetes by STZ (at a dose of 50 mg kg-1 body wt, i.p.) reduced the spleen size, plasma insulin level, enhanced the blood glucose level and disrupted the intracellular antioxidant machineries along with the depletion of splenic white pulp. Induction of oxidative stress mediated inflammation and apoptosis (upregulation in the levels of inflammatory cytokines, translocation of NF ĸB in the nucleus, alteration in Bax/Bcl-2 ratio, release of cytochrome c from mitochondria, activation of caspase-9 and 3, PARP cleavage and DNA fragmentation) were evidenced from immunoblot analyses, DNA fragmentation and TUNEL assay...
May 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29758314/realistic-and-aggregated-exposure-assessment-of-korean-men-and-women-to-color-make-up-products
#18
Kyungeun Jung, Misoo Choi, Seungphil Hong, Byungcheol Park, Ilong Park, Jeonghyun Shin, Taewon Lee, Gyeong-Hun Park, Myunghwa Kim
No abstract text is available yet for this article.
May 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29758313/flavonoids-as-protective-agents-against-oxidative-stress-induced-by-gentamicin-in-systemic-circulation-potent-protective-activity-and-microbial-synergism-of-luteolin
#19
Pamela Soledad Bustos, Romina Deza-Ponzio, Paulina Laura Páez, José Luis Cabrera, Miriam Beatriz Virgolini, María Gabriela Ortega
The flavonoids effect on gentamicin (GEN)-induced oxidative stress (OS) in systemic circulation was evaluated in terms of reactive oxygen species (ROS) production, enzymatic antioxidant defenses superoxide dismutase (SOD) and catalase (CAT), and lipid peroxidation (LP) in vitro on human leukocytes and in vivo on rat whole blood. The inhibitory activity of ROS was ATS < QTS < isovitexin < vitexin < luteolin. Luteolin, the most active, showed more inhibition in ROS production than vitamin C (reference inhibitor) in mononuclear cells and a slightly lower protective behavior compared to this inhibitor in polymorphonuclear cells...
May 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29758312/protocatechuic-acid-methyl-ester-modulates-fluoride-induced-pulmonary-toxicity-in-rats
#20
Jaishabanu Ameeramja, Vishnu Vignesh Kanagaraj, Ekambaram Perumal
We have found that protocatechuic acid methyl ester (PCAME) attenuates fluoride (F- ) toxicity in lung epithelial cells (A549). However, these finding has to be confirmed with in vivo studies. Further, the effect of PCAME on F- induced pulmonary fibrosis and inflammation remains limited. Hence, the present study is aimed to determine the protective effect PCAME against F- induced pulmonary toxicity in female albino Wistar rats. The animals were treated with sodium fluoride (NaF, 300 ppm in drinking water ad libitum) alone or in combination with PCAME (25 or 50 mg/kg bw/day by oral intubation) for 60 days and analyzed for changes in lung histology, oxidative stress, inflammation, apoptosis and fibrosis markers...
May 11, 2018: Food and Chemical Toxicology
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