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Food and Chemical Toxicology

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https://www.readbyqxmd.com/read/29331735/internal-exposure-based-pharmacokinetic-evaluation-of-potential-for-biopersistence-of-6-2-fluorotelomer-alcohol-ftoh-and-its-metabolites
#1
Shruti V Kabadi, Jeffrey Fisher, Jason Aungst, Penelope Rice
Polyfluorinated compounds (PFCs) are authorized for use as greaseproofing agents in food contact paper. As C8-PFCs (8-carbons) are known to accumulate in tissues, shorter-chain C6-PFCs (6-carbons) have replaced C8-PFCs in many food contact applications. However, the potential of C6-PFCs for human biopersistence has not been fully evaluated. For the first time, we provide internal exposure estimates to key metabolites of 6:2 fluorotelomer alcohol (6:2 FTOH), a monomeric component of C6-PFCs, to extend our understanding of exposure beyond estimates of external exposure...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29331734/in-vitro-assessment-of-silver-nanoparticles-immunotoxicity
#2
Valentina Galbiati, Laura Cornaghi, Elisabetta Gianazza, Marco A Potenza, Elena Donetti, Marina Marinovich, Emanuela Corsini
This study aimed to characterize unwanted immune effects of nanoparticles (NP) using THP-1 cells, human whole blood and enriched peripheral blood monocytes. Commercially available silver NP (AgNP < 100 nm, also confirmed by Single Particle Extinction and Scattering) were used as prototypical NP. Cells were treated with AgNP alone or in combination with classical immune stimuli (i.e. LPS, PHA, PWM) and cytokine assessed; in addition, CD54 and CD86 expression was evaluated in THP-1 cells. AgNP alone induced dose-related IL-8 production in all models, with higher response observed in THP-1 cells, possibly connected to different protein corona formation in bovine versus human serum...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29331733/aronia-melanocarpa-fruit-juice-ameliorates-the-symptoms-of-inflammatory-bowel-disease-in-tnbs-induced-colitis-in-rats
#3
Stefka Valcheva-Kuzmanova, Atanas Kuzmanov, Vasilena Kuzmanova, Maria Tzaneva
Trinitrobenzensulfonic acid (TNBS) is commonly used to induce an experimental inflammatory bowel disease (IBD) model. Oxidative stress and inflammation have been proposed as mechanisms underlying the pathophysiology of IBD. Aronia melanocarpa fruit juice (AMFJ) is extremely rich in polyphenolic substances, mainly proanthocyanidins, flavonoids and phenolic acids. The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29331732/computational-toxicology-from-cheminformatics-to-nanoinformatics
#4
EDITORIAL
Georgia Melagraki, Antreas Afantitis
No abstract text is available yet for this article.
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29331731/deoxynivalenol-gut-microbiota-and-immunotoxicity-a-potential-approach
#5
REVIEW
Yuxiao Liao, Zhao Peng, Liangkai Chen, Andreas K Nüssler, Liegang Liu, Wei Yang
Deoxynivalenol (DON, vomitoxin) is the most frequent mycotoxin in grains and grain products. DON contamination in fodder and food is a serious threat for health, since it impairs the immune and gastrointestinal systems of both human and animals. Gut microbiota seems to play a more and more important part in human and animals' health according to related researches. Previous studies implied some associations among gut microbiota, DON and immune system. For example, DON affects immune system as well as the composition and abundance of gut microbiota, and the latter influences immune system as well...
January 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29330117/rifm-fragrance-ingredient-safety-assessment-phenethyl-isovalerate-cas-registry-number-140-26-1
#6
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29325807/rifm-fragrance-ingredient-safety-assessment-dodecanenitrile-cas-registry-number-2437-25-4
#7
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29325806/rifm-fragrance-ingredient-safety-assessment-pentanedioic-acid-1-5-dimethyl-ester-cas-registry-number-1119-40-0
#8
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29317331/rifm-fragrance-ingredient-safety-assessment-benzyl-formate-cas-registry-number-104-57-4
#9
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S L A Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29317330/comprehensive-evaluation-of-the-flavonol-anti-oxidants-alpha-glycosyl-isoquercitrin-and-isoquercitrin-for-genotoxic-potential
#10
Cheryl A Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Sawako Kasamoto, Robert Maronpot, Leslie Recio, Shim-Mo Hayashi
Quercetin and its glycosides possess potential benefits to human health. Several flavonols are available to consumers as dietary supplements, promoted as anti-oxidants; however, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce alpha-glycosyl isoquercitrin (AGIQ) enhances solubility and bioavailability. AGIQ is used in Japan as a food additive and has been granted generally recognized as safe (GRAS) status...
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29317329/rifm-fragrance-ingredient-safety-assessment-5-8-methano-2h-1-benzopyran-2-one-6-ethylideneoctahydro-cas-registry-number-69486-14-2
#11
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29317328/investigation-of-in-vitro-genotoxic-effects-of-an-anti-diabetic-drug-sitagliptin
#12
Deniz Yuzbasioglu, Cemile Enguzel-Alperen, Fatma Unal
Sitagliptin is an active ingredient of antidiabetic drug used in the treatment of type 2 diabetes mellitus (T2DM). In this study, the genotoxic effects of sitagliptin were determined in human lymphocytes by using chromosome aberrations (CAs), sister chromatid exchanges (SCEs), micronucleus (MN) and comet assays. 31.25-1000 μg/mL concentrations of sitagliptin were used. Sitagliptin significantly increased the frequency of CAs and SCEs at the highest concentration at 24 h treatment and all concentrations (except 250 μg/mL for CA, except 31...
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29309824/ochratoxin-a-toxicity-oxidative-stress-and-metabolism
#13
REVIEW
Yanfei Tao, Shuyu Xie, Fanfan Xu, Yanxin Wang, Dongmei Chen, Yuanhu Pan, Lingli Huang, Dapeng Peng, Xu Wang, Zonghui Yuan
Ochratoxin A (OTA) is a widespread mycotoxin commonly found as a corn contaminant. It has been shown to be nephrotoxic, hepatotoxic, teratogenic and immunotoxic to several species of animals and to cause kidney and liver tumors in mice and rats. The focus of this article is primarily intended to summarize the progress in research associated with oxidative stress as a plausible mechanism for OTA-induced toxicity as well as its metabolism. The present review shows that studies have been carried out for decades to elucidate the production of reactive oxygen species (ROS) and oxidative stress as a result of OTA treatment and have correlated them with various types of OTA toxicity, indicating that oxidative stress plays critical roles in the toxicity of OTA...
January 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29307602/essential-roles-of-akt-snail-pathway-in-microcystin-lr-induced-tight-junction-toxicity-in-sertoli-cell
#14
Yuan Zhou, Xiao Geng, Yu Chen, Hao Shi, Yan Yang, Chan Zhu, Guang Yu, Zongxiang Tang
Microcystin (MC)-LR is a cyclic heptapeptide that acts as a potent reproductive system toxin. However, the underlying pathways of MCLR-induced reproductive system toxicity have not been well elucidated. The blood-testis barrier is mainly constituted by tight junctions (TJs) between adjacent Sertoli cells in the seminiferous epithelium near the basement membrane. The present study was designed to investigate changes in TJs and the underlying pathway in MC-LR-induced TJs toxicity in Sertoli cell. In our study, the transepithelial electrical resistance (TER) value was decreased in a dose dependent manner due to the markers of TJs occludin, claudin and zonula occludens-1 (ZO-1) expression decline...
January 4, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29307601/a-comparative-study-of-human-ige-binding-to-proteins-of-a-genetically-modified-gm-soybean-and-six-non-gm-soybeans-grown-in-multiple-locations
#15
Mei Lu, Yuan Jin, Barbara Ballmer-Weber, Richard E Goodman
Prior to commercialization, genetically modified (GM) crops are evaluated to determine the allergenicity of the newly expressed protein. Some regulators require an evaluation of endogenous allergens in commonly allergenic crops including soybean to determine if genetic transformation increased endogenous allergen concentrations, even asking for IgE testing using sera from individual sensitized subjects. Little is known about the variability of the expression of endogenous allergens among non-GM varieties or under different environmental conditions...
January 4, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29305932/rifm-fragrance-ingredient-safety-assessment-3-methyl-5-2-2-3-trimethyl-3-cyclopenten-1-yl-pent-4-en-2-ol-cas-registry-number-67801-20-1
#16
A M Api, D Belsito, S Bhatia, D Botelho, D Browne, M Bruze, A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, L Kromidas, S L A Cava, J F Lalko, A Lapczynski, D C Liebler, Y Miyachi, D O'Brien, R Parakhia, A Patel, T M Penning, V T Politano, G Ritacco, J Romine, D Salvito, T W Schultz, J Shen, I G Sipes, Y Thakkar, Y Tokura, S Tsang, J Wahler, B Wall, D K Wilcox
No abstract text is available yet for this article.
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29305931/discrimination-of-three-siegesbeckiae-herba-species-using-uplc-qtof-ms-based-metabolomics-approach
#17
Hong-Xun Tao, Wei Xiong, Guan-Ding Zhao, Yu Peng, Zhang-Feng Zhong, Liang Xu, Ran Duan, Karl W K Tsim, Hua Yu, Yi-Tao Wang
The plant origin is one of the most important factors for the quality control of traditional Chinese medicines (TCMs) and highly affected on their safety and effectiveness in clinical applications. Multi-origin has been widely observed for many TCMs. Siegesbeckiae Herba (SH) is a traditional anti-rheumatic TCM which is originated from the plants of Siegesbeckia pubescens Makino (SP), S. orientalis L. (SO), and S. glabrescens Makino (SG). In the present study, an UPLC-QTOF/MS method were validated and successfully applied for the determination of the chemical profiles in the three SH species...
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29305930/rifm-fragrance-ingredient-safety-assessment-phenethyl-tiglate-cas-registry-number-55719-85-2
#18
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29305929/cytochrome-p450-4a11-inhibition-assays-based-on-characterization-of-lauric-acid-metabolites
#19
Yeon Jung Choi, Yuanyuan Zhou, Ji-Yoon Lee, Chang Seon Ryu, Young Ho Kim, Kiho Lee, Sang Kyum Kim
No abstract text is available yet for this article.
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29305928/anti-proliferative-activity-of-biochanin-a-in-human-osteosarcoma-cells-via-mitochondrial-involved-apoptosis
#20
Yen-Nien Hsu, Huey-Wen Shyu, Tsui-Wen Hu, Jou-Pei Yeh, Ya-Wen Lin, Ling-Yi Lee, Yao-Tsung Yeh, Hong-Ying Dai, Daw-Shyong Perng, Shu-Hui Su, Yu-Hsuan Huang, Shu-Jem Su
Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a minimal toxicity to normal cells. The combination of doxorubicin and biochanin A could synergistically inhibit osteosarcoma cell growth...
January 3, 2018: Food and Chemical Toxicology
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