journal
MENU ▼
Read by QxMD icon Read
search

Food and Chemical Toxicology

journal
https://www.readbyqxmd.com/read/30634014/effect-of-inositol-stabilized-arginine-silicate-on-arthritis-in-a-rat-model
#1
Kazim Sahin, Sara Perez Ojalvo, Fatih Akdemir, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Ibrahim H Ozercan, Sarah Sylla, Suleyman S Koca, Ismet Yilmaz, James R Komorowski
The purpose of this study was to test the effects of arginine-silicate-inositol complex (ASI), compared to a combination of the individual ingredients (A+S+I) of the ASI, on inflammatory markers and joint health in a collagen-induced arthritis (CIA) rat model. A total of 28 Wistar rats were divided into four groups: (i) Control; (ii) Arthritic group, rats subjected to CIA induction by injection of bovine collagen type II (A); (iii) Arthritic group treated with equivalent doses of the separate components of the ASI complex (arginine hydrochloride, silicon, and inositol) (A+S+I); (iv) Arthritic group treated with the ASI complex...
January 8, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30634013/further-analysis-of-rat-myocardium-contractility-changes-associated-with-a-subchronic-lead-intoxication
#2
Yuri L Protsenko, Boris A Katsnelson, Svetlana V Klinova, Oleg N Lookin, Alexander A Balakin, Larisa V Nikitina, Oksana P Gerzen, Salavat R Nabiev, Ilzira A Minigalieva, Larisa I Privalova, Vladimir B Gurvich, Marina P Sutunkova, Leonid B Katsnelson
A moderate subchronic lead intoxication was observed in male rats after repeated intraperitoneal injections of lead acetate. Right ventricular trabeculae and papillary muscles were isolated for in vitro studying of the contraction-relaxation cycle under isotonic and physiological loading. The contractile function of the myocardium was also assessed by measuring the velocity of thin filament movement over myosin. Lead intoxication led in papillary muscles to a decrease in the maximal rate of isotonic shortening for all afterloads and a decrease in the thin filament sliding velocity...
January 8, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30615957/metabolism-of-cyanogenic-glycosides-a-review
#3
REVIEW
Peter Cressey, John Reeve
Potential toxicity of cyanogenic glycosides arises from enzymatic degradation to produce hydrogen cyanide. Information on the metabolism of cyanogenic glycosides is available from in vitro, animal and human studies. In the absence of β-glucosidase enzymes from the source plant material, two processes appear to contribute to the production of cyanide from cyanogenic glycosides; the proportion of the glycoside dose that reaches the large intestine, where most of the bacterial hydrolysis occurs, and the rate of hydrolysis of cyanogenic glycosides to cyanohydrin and cyanide...
January 4, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30615956/the-relationship-between-zinc-intake-and-cadmium-burden-is-influenced-by-smoking-status
#4
Kijoon Kim, Melissa M Melough, Terrence M Vance, Dongwoo Kim, Hwayoung Noh, Sung I Koo, Ock K Chun
A preliminary study by our group suggested that the absorption and accumulation of cadmium may be affected by zinc intake. Tobacco smoke is one major source of cadmium exposure that highly influences cadmium burden among smokers, but it is unclear whether this zinc-cadmium relationship differs by smoking status. The objective of this study was to examine whether the association between zinc intake and cadmium burden differs by smoking status using data from 3900 US adults in the National Health and Nutrition Examination Survey 2007-2012...
January 4, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30615955/carvacrol-%C3%AE-cyclodextrin-inclusion-complex-inhibits-cell-proliferation-and-migration-of-prostate-cancer-cells
#5
Gabriela G G Trindade, Greeshma Thrivikraman, Paula P Menezes, Cristiane M França, Bruno S Lima, Yasmim M B G Carvalho, Eloísa P B S S Souza, Marcelo C Duarte, Saravanan Shanmugam, Lucindo J Quintans-Júnior, Daniel P Bezerra, Luiz E Bertassoni, Adriano A S Araújo
Carvacrol, a phenolic monoterpene derived from thyme oil has gained wide interest recently because of its anticancer activities. To improve the solubility of carvacrol, the formation of inclusion complexes with β-cyclodextrin was performed by ultrasound and freeze-drying methods and characterized using thermal analysis, FTIR, XRD, SEM, NMR and HPLC analysis. From these results, carvacrol was successfully complexed within β-cyclodextrin cavity. Moreover, HPLC analysis demonstrated a higher entrapment efficiency for freeze-drying method (81...
January 4, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30610937/response-to-comment-on-article
#6
LETTER
(no author information available yet)
No abstract text is available yet for this article.
January 2, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30610936/suppression-of-plasminogen-activator-inhibitor-1-pai-1-activity-by-crocin-ameliorates-lipopolysaccharide-induced-thrombosis-in-rats
#7
M P Tsantarliotou, S N Lavrentiadou, D A Psalla, I E Margaritis, M G Kritsepi, I A Zervos, M I Latsari, V G Sapanidou, I A Taitzoglou, Z M Sinakos
The imbalance between clot formation and fibrinolysis is mainly attributed to increased levels of plasminogen activator inhibitor type 1 (PAI-1), an inhibitor of fibrinolysis closely involved in inflammatory responses such as septic shock. This increase is mediated by many factors, including reactive oxygen species (ROS). The present study was designed to evaluate the prophylactic effect of crocin, a potent natural antioxidant, on PAI-1 in the rat model of endotoxic shock. Lipopolysaccharide-infused rats (500 μg/kg) showed significant changes in thrombosis-related haematological parameters such as decrease of platelet blood counts and increase (7 fold) of PAI-1 concentration in blood plasma...
January 2, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30610935/assessment-of-a-72-hour-repeated-exposure-to-swedish-snus-extract-and-total-particulate-matter-from-3r4f-cigarettes-on-gingival-organotypic-cultures
#8
Filippo Zanetti, Alain Sewer, Bjoern Titz, Walter K Schlage, Anita R Iskandar, Athanasios Kondylis, Patrice Leroy, Emmanuel Guedj, Keyur Trivedi, Ashraf Elamin, Florian Martin, Stefan Frentzel, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng
Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds smoking among men, relatively low rates of major smoking-related diseases have been recorded. To better understand how snus use could align with current tobacco harm reduction strategies, its potential mechanisms of toxicity must be investigated. This study aimed to determine, via a systems toxicology approach, the biological impact of repeated 72-hour exposure of human gingival epithelial organotypic cultures to extracts from both a commercial and a reference snus and the total particulate matter (TPM) from cigarette smoke...
January 2, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30610934/short-term-regulation-of-the-hepatic-activities-of-cytochrome-p450-and-glutathione-s-transferase-by-nose-only-cigarette-smoke-exposure-in-mice
#9
Chang Seon Ryu, Young Jae Choi, Hyo Seon Nam, Jang Su Jeon, Taeyoon Jung, Ji-Eun Park, Seong-Jin Choi, Kyuhong Lee, Moo-Yeol Lee, Sang Kyum Kim
The present study aimed to determine the effects of cigarette smoke on the regulation of hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) enzymes in male BALB/c mice exposed to nose-only cigarette smoke for 4 days. There were no significant increases in serum liver injury markers (alanine aminotransferase and aspartate aminotransferase) or oxidative stress (total antioxidant capacity, malondialdehyde, and glutathione disulfide/reduced glutathione) following cigarette smoke exposure, but malondialdehyde was elevated in the bronchoalveolar lavage fluid of smoke-exposed mice...
January 2, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30610933/nigella-damascena-l-essential-oil-and-its-main-constituents-damascenine-and-%C3%AE-elemene-modulate-inflammatory-response-of-human-neutrophils-ex-vivo
#10
Elwira Sieniawska, Piotr Michel, Tomasz Mroczek, Sebastian Granica, Krystyna Skalicka-Woźniak
Nigella damascena L belongs to Ranunculaceae family and is mentioned in Eastern traditional medicine for the treatment of high temperatures, regulation of menstruation or catarrhal affections. The anti-inflammatory activity of compounds present in the essential oil obtained from seeds of this plant can be found in literature, however no studies on immunomodulatory activity are provided. Hence, in this work anti-inflammatory activity of N. damascena seed essential oil as well as damascenine and main compound β-elemene was evaluated on ex-vivo lipopolysaccharide (LPS)-stimulated human neutrophils...
January 2, 2019: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30605701/rifm-fragrance-ingredient-safety-assessment-isoamyl-phenylacetate-cas-registry-number-102-19-2
#11
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
December 31, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30605700/comment-on-article-are-wild-and-cultivated-flowers-served-in-restaurants-or-sold-by-local-producers-in-denmark-safe-for-the-consumer-food-and-chemical-toxicology-120-2018-129-142-doi-10-1016-j-fct-2018-07-007
#12
LETTER
https://www.readbyqxmd.com/read/30602125/hourly-and-daily-intake-patterns-among-u-s-caffeinated-beverage-consumers-based-on-the-national-health-and-nutrition-examination-survey-nhanes-2013-2016
#13
S M Benson, K M Unice, M E Glynn
Characterization of 'hour-of-day' or 'day-of-week' caffeine intake for the National Health and Nutrition Examination Survey (NHANES) population is limited. No study has focused on patterns from an individual perspective. The NHANES 2013-2016 survey respondents' dietary recalls were analyzed to gain a better understanding of caffeine intake patterns for different caffeinated beverage consumer types - defined by beverage type consumed and daily caffeine intake levels. Dominant caffeinated beverage consumers (≥143 mg) were identified by a reported daily caffeine intake level greater than or equal to the 50th percentile among those 1-80 y...
December 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30602124/glucosamine-induces-increased-musclin-gene-expression-through-endoplasmic-reticulum-stress-induced-unfolding-protein-response-signaling-pathways-in-mouse-skeletal-muscle-cells
#14
Qian Guo, Hailong Hu, Ying Zhou, Yuheng Yan, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Hongjuan He, Yuri Oh, Kun Chen, Qiong Wu, Chuanpeng Liu, Ning Gu
Glucosamine (GlcN) is a dietary supplement that is widely used to promote joint health. Reports have demonstrated that oral GlcN adversely affects glucose metabolism. Here, we found that oral administration of GlcN induced insulin resistance (IR) and increased plasma glucose levels in mice. Musclin is a muscle-secreted cytokine that participates in the development and aggravation of diabetes. In this study, we found that increased expression of the musclin plays a pathogenic role in GlcN-induced IR in mice...
December 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30599149/rifm-fragrance-ingredient-safety-assessment-ethyl-levulinate-cas-registry-number-539-88-8
#15
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
December 29, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30599148/rifm-fragrance-ingredient-safety-assessment-4-heptanone-cas-registry-number-123-19-3
#16
A M Api, D Belsito, D Botelho, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, L Jones, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, A Patel, T M Penning, G Ritacco, J Romine, N Sadekar, D Salvito, T W Schultz, I G Sipes, G Sullivan, Y Thakkar, Y Tokura, S Tsang
No abstract text is available yet for this article.
December 29, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30597224/hepatotoxicity-induced-by-psoralen-and-isopsoralen-from-fructus-psoraleae-wistar-rats-are-more-vulnerable-than-icr-mice
#17
Yu Wang, Hong Zhang, Jia-Ming Jiang, Dan Zheng, Yu-Yu Chen, Shi-Jie Wan, Hong-Sheng Tan, Li-Ming Tang, Hong-Xi Xu
Fructus Psoraleae (FP) causes cholestatic liver injury; however, its main toxic constituents that are responsible for causing hepatotoxicity remained undetermined in previous studies. In the present study, psoralen and isopsoralen, the two main constituents of FP, were administered orally to rats (80 and 40 mg/kg, respectively) and mice (320 and 160 mg/kg, respectively) for 28 days, followed by biochemical and histopathological examinations to evaluate their hepatotoxicity. The results showed that psoralen and isopsoralen could induce the toxic reactions of liver and other organs in rats, while mice were not sensitive to these two compounds...
December 28, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30597223/protocatechuic-acid-ameliorates-neurobehavioral-deficits-via-suppression-of-oxidative-damage-inflammation-caspase-3-and-acetylcholinesterase-activities-in-diabetic-rats
#18
Isaac A Adedara, Opeyemi B Fasina, Modupe F Ayeni, Olamide M Ajayi, Ebenezer O Farombi
Clinical and experimental data have demonstrated that diabetes is associated with neurological complications. Protocatechuic acid (PCA) is a phenolic phytochemical widely reported to possess antidiabetic property. However, there is no scientific information on the influence of PCA on diabetes-induced neurotoxicity. The present study aimed at investigating the neuroprotective mechanism of PCA in streptozotozin (STZ)-induced type 1 diabetic rats orally treated with PCA (50 mg/kg body weight) or glibenclamide (5 mg/kg body weight) for 45 consecutive days...
December 28, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30597222/occurrence-and-toxicity-of-microcystin-congeners-other-than-mc-lr-and-mc-rr-a-review
#19
REVIEW
Leticia Díez-Quijada, Ana I Prieto, Remedios Guzmán-Guillén, Angeles Jos, Ana M Cameán
The occurrence of cyanobacterial toxins is being increasingly reported. This is a reason for concern as they can induce toxic effects both in humans and in the environment. Among them, microcystins (MCs) are the best described and most diverse group of cyanobacterial toxins, and MC-LR and MC-RR are the congeners most widely investigated. However, the number of MC variants has also increased in recent years. Some of these minority variants have been shown to have a different toxicokinetic and toxicodynamic profile, but research focused on them is still limited...
December 28, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/30597221/kiwifruit-seed-oil-prevents-obesity-by-regulating-inflammation-thermogenesis-and-gut-microbiota-in-high-fat-diet-induced-obese-c57bl-6-mice
#20
Linlin Qu, Qingqing Liu, Qi Zhang, Xingxia Tuo, Daidi Fan, Jianjun Deng, Haixia Yang
Obesity is considered as a chronic disease which seriously affecting people's health and daily life. Kiwifruit (Actinidia chinensis Planch) seed oil (KSO), as a by-product of kiwifruit processing, is rich in fatty acids. Conventional wisdom holds that KSO has many health benefits, but there is no scientific basis. Here, the relieving effects of KSO on obesity and its potential mechanism were investigated in high-fat diet (HFD)-induced C57BL/6 mice. Mice were divided into four groups: ND (normal diet); HFD; L-KSO and H-KSO (HFD supplemented with 1...
December 28, 2018: Food and Chemical Toxicology
journal
journal
28339
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"