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Rheumatology International

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https://www.readbyqxmd.com/read/28324133/foot-health-in-patients-with-rheumatoid-arthritis-a-scoping-review
#1
REVIEW
Minna Stolt, Riitta Suhonen, Helena Leino-Kilpi
Rheumatoid arthritis affects joints and can cause significant impairments in daily life. The foot is often the first site of symptoms and foot problems are strongly related to RA. The aim of this review was, therefore, to describe foot health in patients with rheumatoid arthritis and to identify how patients perform foot self-care. With this knowledge interventions to support foot health and functional ability in RA patients can be developed. The design of the review was a scoping review. A systematic literature search of three electronic databases, MEDLINE, CINAHL and Embase, was conducted in June 2016...
March 21, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28293776/long-term-outcomes-of-treat-to-target-strategy-in-established-rheumatoid-arthritis-a-daily-practice-prospective-cohort-study
#2
Nicole Pamplona Bueno de Andrade, Rafael Mendonça da Silva Chakr, Ricardo Machado Xavier, Daniela Viecceli, Ricardo Henrique Bilycz Correa, Cilomar Martins de Oliveira Filho, Claiton Viegas Brenol
To examine disease activity and physical function after implementation of treat-to-target (T2T) strategy in patients with established rheumatoid arthritis (RA) over a long-term period. Patients with RA were started on a T2T strategy in 2005 and followed through 2014. Patients were seen every 3-4 months until remission/low disease activity was achieved and every 6 months thereafter. Disease activity was measured by the DAS28 and CDAI, and physical function by the HAQ-DI. Results were presented as all observed data, without imputation for missing values...
March 14, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28293775/inflammatory-status-and-uricaemia-determine-hdl-cholesterol-levels-in-hypertensive-adults-over-65-an-analysis-of-the-fapres-register
#3
María Amparo Quintanilla, Mariano Andrés, Eliseo Pascual, Vicente Pallarés, Lorenzo Fácila, Pedro Morillas
In inflammatory disease, the levels of high-density lipoprotein cholesterol (HDL-C) decrease, and the composition of HLD-C changes. Data from the "non-inflammatory" general population indicate the presence of the same phenomenon, albeit to a smaller extent. Levels of uricaemia contribute to the overall inflammatory state of patients. The aim of this study was to analyse the association between inflammatory state, levels of uricaemia, and levels of HLD-C in a hypertensive Spanish population aged 65 or older...
March 14, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28289874/renal-vasculitis-presenting-with-acute-kidney-injury
#4
Javier Villacorta, Francisco Diaz-Crespo, Mercedes Acevedo, Teresa Cavero, Carmen Guerrero, Manuel Praga, Gema Fernandez-Juarez
Renal failure secondary to ANCA-associated vasculitis represents a clinical and therapeutic challenge. In this study, we aimed to assess the treatment response rates and long-term outcomes of vasculitis patients presenting with renal failure. This retrospective study included 151 patients with renal vasculitis from three hospitals who underwent a renal biopsy between 1997 and 2014. Patients with renal failure which required dialysis at the onset were compared to those presenting with more preserved renal function...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28289873/patient-reported-outcomes-as-predictors-of-remission-in-early-rheumatoid-arthritis-patients-treated-with-tight-control-treat-to-target-approach
#5
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Timo Yli-Kerttula, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Identifying prognostic factors for remission in early rheumatoid arthritis (ERA) patients is of key clinical importance. We studied patient-reported outcomes (PROs) as predictors of remission in a clinical trial. We randomized 99 untreated ERA patients to receive remission-targeted treatment with three disease-modifying antirheumatic drugs and prednisolone for 24 months, and infliximab or placebo for the initial 6 months. At baseline, we measured following PROs: eight Short Form 36 questionnaire (SF-36) dimensions, patient's global assessment [PGA, visual analogue scale (VAS)], Health Assessment Questionnaire (HAQ), and pain VAS...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28289872/criteria-sets-for-primary-sjogren-s-syndrome-are-not-adequate-for-those-presenting-with-extraglandular-organ-involvements-as-their-dominant-clinical-features
#6
Yasemin Kabasakal, Gul Kitapçıoğlu, Gonca Karabulut, Mehmet Tezcan, Ayse Balkarlı, Adem Aksoy, Şule Yavuz, Sema Yılmaz, Timuçin Kaşifoğlu, Umut Kalyoncu, Ediz Dalkılıç, Abdurrahman Tufan, Rıdvan Mercan, Fatih Yıldız, Taşkın Şentürk, Fatoş Önen, Cemal Bes, Eren Erken, Ercan Tunç, Sevil Kamalı, Emine Tarhan, Ayten Yazıcı, Nurşen Düzgün, Müge Bıçakçıgil, Sedat Yılmaz, Mustafa Özmen, Lale Öcal, Fatma Alibaz-Öner, Dilek Solmaz, Veli Çobankara, Selim Nalbant, Esen Kasapoğlu Günal, Derya Kaşkari, Berna Göker
Patients with primary Sjogren's syndrome (pSS) may go undiagnosed or be misclassified due to the insidious nature and wide spectrum of the disease. The available several classification criteria emphasize glandular findings. We aimed to analyze the efficiency of various classification criteria sets in patients diagnosed on the clinical basis by expert opinion and to compare those pSS patients who fulfilled these criteria with those who did not. This is a multicenter study in which 834 patients from 22 university-based rheumatology clinics are included...
March 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28286904/short-and-long-term-mortality-due-to-sepsis-in-patients-with-rheumatoid-arthritis
#7
Orit Barrett, Ella Abramovich, Jacob Dreiher, Victor Novack, Mahmoud Abu-Shakra
Severe infections and sepsis are common among patients with rheumatoid arthritis (RA) and are associated with increased morbidity and mortality risks. To determine whether RA is an independent risk factor for short- and long-term mortality in patients admitted to an Intensive Care Unit (ICU) with sepsis. A retrospective age- and sex-matched cohort study, based on data of the SEPSIS-ISR Registry, an ongoing study that collects data on all patients admitted with the diagnosis of sepsis to the ICUs of 7 large hospitals during the period 2002-2012...
March 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28286903/the-risk-of-tuberculosis-in-sle-patients-from-an-asian-tertiary-hospital
#8
Yong Yang, Julian Thumboo, Ban Hock Tan, Thuan Tong Tan, Chern Hui Jeffrey Fong, Han Seong Ng, Kok Yong Fong
Systemic lupus erythematosus (SLE) has been associated with increased risk of tuberculosis (TB). However, little is known about the extent and risk factors for TB among Asian patient with SLE. We aimed to assess the rate of TB in patients with SLE, and investigate the risk of SLE on TB development using hospital administrative database. This is an historical cohort study of hospital discharge database from 2004 to 2011 to identify cases with SLE and TB using International Statistical Classification of Diseases and Related Health Problems, 9th Revision, Australian Modification (ICD-9-AM) codes...
March 12, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28283734/intestinal-perforation-due-to-hemorrhagic-cytomegalovirus-enteritis-in-a-patient-with-severe-uncontrolled-lupus-nephritis-a-case-and-review-of-the-literature
#9
REVIEW
Keigo Ikeda, Shihoko Nakajima, Kana Tanji, Takuya Hirai, Kaori Uomori, Shinji Morimoto, Shigeki Tomita, Masaki Fukunaga, Naoto Tamura, Iwao Sekigawa
A 31-year-old woman with systemic lupus erythematosus and lupus nephritis was treated with prednisone and immunosuppressants. After her lupus nephritis symptoms worsened, both high-dose steroid and cyclophosphamide pulse therapy were administered. The patient developed an intestinal perforation, and laparoscopic Hartmann's surgery was performed on the sigmoid colon. Serum Cytomegalovirus (CMV) antigen C7HRP was detected, and the patient was diagnosed with CMV colitis and underwent a colon resection. Severe hematochezia continued despite ganciclovir administration, and the patient underwent laparoscopic total colectomy and partial ileostomy...
March 11, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28283733/high-sensitive-crp-as-a-predictive-marker-of-long-term-outcome-in-juvenile-idiopathic-arthritis
#10
Mikel Alberdi-Saugstrup, Marek Zak, Susan Nielsen, Troels Herlin, Ellen Nordal, Lillemor Berntson, Anders Fasth, Marite Rygg, Klaus Müller
To evaluate whether C-reactive protein (CRP), including variation within the normal range, is predictive of long-term disease outcome in Juvenile Idiopathic Arthritis (JIA). Consecutive patients with newly diagnosed JIA were included prospectively from defined geographic areas of the Nordic countries from 1997 to 2000. Inclusion criteria were availability of a baseline serum sample within 12 months after disease onset and 8-year clinical assessment data. Systemic onset JIA was not included. CRP was measured by high-sensitive ELISA (detection limit of 0...
March 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28280970/belimumab-use-clinical-outcomes-and-glucocorticoid-reduction-in-patients-with-systemic-lupus-erythematosus-receiving-belimumab-in-clinical-practice-settings-results-from-the-observe-canada-study
#11
Zahi Touma, Amyn Sayani, Christian A Pineau, Isabelle Fortin, Mark Matsos, George A Ecker, Andrew Chow, Sandra Iczkovitz
To describe the characteristics of patients receiving belimumab, overall patterns of systemic lupus erythematosus (SLE) care, clinical outcomes, and changes in glucocorticoid dose following 6 months of therapy with belimumab, and healthcare resource utilization in belimumab users in Canadian clinical practice settings. Retrospective multicenter medical chart review study of adult patients with SLE who were prescribed belimumab as part of usual care and who received ≥8 infusions or 6 months of treatment...
March 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28271158/physicians-perspectives-on-the-diagnosis-and-management-of-periodic-fever-aphthous-stomatitis-pharyngitis-and-cervical-adenitis-pfapa-syndrome
#12
Kalpana Manthiram, Suzanne C Li, Jonathan S Hausmann, Gil Amarilyo, Karyl Barron, Hanna Kim, Simona Nativ, Geraldina Lionetti, Andrew Zeft, Donald Goldsmith, David Kimberlin, Kathryn Edwards, Fatma Dedeoglu, Sivia Lapidus
To assess the practice patterns of pediatric rheumatology and infectious diseases subspecialists in the diagnosis and treatment of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome. An online survey assessing diagnostic and treatment approaches was sent to 424 members of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) and 980 members of the Pediatric Infectious Disease Society (PIDS). 277 physicians (123 from CARRA and 154 from PIDS representing 21% of the total membership) completed the survey...
March 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28271157/validation-of-serbian-version-of-ucla-scleroderma-clinical-trial-consortium-gastrointestinal-tract-instrument-in-104-patients-with-systemic-sclerosis
#13
Ana Zekovic, Nemanja Damjanov
Gastrointestinal (GI) involvement is the leading cause of morbidity with great impact on health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc). The UCLA-GIT 2.0 is a disease-specific HRQOL instrument for the assessment of GI symptoms severity in patients with SSc. We evaluated reliability and validity of the Serbian version of UCLA-GIT 2.0 by assessing association of GI involvement and other disease manifestations in patients with SSc. UCLA-GIT 2.0 was adapted into Serbian and administered to 104 patients with SSc who had previously completed the SF-36 questionnaire...
March 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28258475/expanding-the-therapeutic-options-for-renal-involvement-in-lupus-eculizumab-available-evidence
#14
REVIEW
Savino Sciascia, Massimo Radin, Jinoos Yazdany, Maria Tektonidou, Irene Cecchi, Dario Roccatello, Maria Dall'Era
In this study, we aimed to systematically review available literature on the efficacy of eculizumab for the treatment of renal involvement in patients with systemic lupus erythematosus (SLE). We conducted a literature search developed a priori, to identify articles reporting clinical experience with the use of eculizumab in SLE patients, focusing on renal involvement. The search strategy was applied to Ovid MEDLINE, EMBASE, In-Process and Other Non-Indexed Citation, Cochrane Central Register of Controlled Trials and Scopus from 2006 to present...
March 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28258474/impact-of-ultrasonography-on-treatment-decision-in-rheumatoid-arthritis-the-impulsar-study
#15
Cèsar Díaz-Torné, Carme Moragues, Elide Toniolo, Carme Geli, Iván Castellví, Patricia Moya, Ignasi Gich, Josep M Llobet
Ultrasonography (US) has shown to be more sensitive than physical examination for diagnosis and assessment of rheumatoid arthritis (RA). It is also a useful approach for accurate monitoring and intensive treatment adjustment. However, there is limited information concerning the impact of US on therapeutic decision-making in routine daily practice. A single-center cross-sectional study in routine daily practice was conducted to determine the percentage of patients with rheumatoid arthritis (RA) in which treatment decision was modified on the basis of results of musculoskeletal ultrasonography...
March 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28258473/sarcopenia-in-rheumatoid-arthritis-prevalence-influence-of-disease-activity-and-associated-factors
#16
Ange Ngeuleu, F Allali, L Medrare, A Madhi, H Rkain, N Hajjaj-Hassouni
Evaluate the prevalence of sarcopenia on patients with rheumatoid arthritis (RA), the influence of sarcopenia on disease activity and factors associated with sarcopenia. One hundred and twenty-three patients aged over 18 years with RA based on the 1987 ACR/EULAR classification criteria were enrolled. We performed a whole body DXA scan using a dual-energy X-ray absorptiometry (DXA) scanner lunar prodigy to measure fat mass, lean mass, and bone mass in the whole body and body parts. According to the anthropometric equation by Baumgartner et al...
March 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28255645/efficacy-of-mizoribine-and-prednisolone-combination-therapy-in-adult-patients-with-iga-vasculitis
#17
Akira Mima
Immunoglobulin (Ig)A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is one of the most common vasculitis caused by an IgA-mediated immune complex. It occurs most frequently in childhood and less commonly in adulthood. As for the treatment of IgAV in adults, there are few studies dealing with the administration and efficacy of intravenous pulse steroid therapy or combination therapy using prednisolone (PSL) and immunosuppressive drugs. Mizoribine (MZB) is a newly developed immunosuppressive drug with few adverse effects; however, there are currently few studies using MZB in adult patients with IgAV...
March 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28255644/etanercept-induced-leukemia-could-increased-mean-corpuscular-volume-be-a-predictor-of-hematologic-malignancy
#18
REVIEW
Döndü Üsküdar Cansu, Hava Üsküdar Teke, Cengiz Korkmaz
In rheumatology practice, anti-tumor necrosis factor (TNF) alpha agents are frequently used medications, more so in ankylosing spondylitis (AS). There are case reports, besides their adverse effects, such as infection and injection site reaction, suggesting these agents may cause solid or hematologic malignancies. Acute leukemia secondary to anti-TNF alpha agents has been rarely reported in patients with AS. In this case report, based on a patient who developed acute leukemia while on the treatment with etanercept, we will discuss whether it is possible to predict acute leukemia by monitoring the mean corpuscular volume in light of the literature...
March 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28255643/use-of-etanercept-to-treat-rheumatoid-arthritis-in-an-hiv-positive-patient-a-case-based-review
#19
REVIEW
Shen-Ju Liang, Quan-You Zheng, Yan-Long Yang, Yi Yang, Chong-Yang Liu
Rheumatoid arthritis (RA) is a relatively common autoimmune disease that is associated with progressive disability and systemic complications, with a relatively high socioeconomic burden. The treatment of RA has been revolutionized by the use of biological drugs, such as anti-tumor necrosis factor (TNF) agents. A wide spectrum of RA disease severity has been reported among patients with human immunodeficiency virus (HIV) infection. Yet, only a few cases using anti-TNF therapy have been described in this clinical population...
March 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28255642/dose-relationship-between-oral-glucocorticoids-and-tumor-necrosis-factor-inhibitors-and-the-risk-of-hospitalized-infectious-events-among-patients-with-rheumatoid-arthritis
#20
Jennifer Schenfeld, Jan Iles, Mona Trivedi, Neil A Accortt
The objective of this study was to evaluate the impact of oral glucocorticoid (GC) dose on rates of hospitalized infectious events (HIEs) among RA patients newly exposed to tumor necrosis factor inhibitor (TNFi) therapy. This retrospective cohort study used data from the MarketScan claims database. Incident and prevalent adult RA patients newly exposed to TNFi therapy were identified and assigned to three cohorts: no GC, low-dose GC (≤7.5 mg), and high-dose GC (>7.5 mg); patients could contribute exposure time to multiple cohorts if they changed dose or discontinued GC...
March 2, 2017: Rheumatology International
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