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Rheumatology International

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https://www.readbyqxmd.com/read/30229280/infliximab-biosimilar-ct-p13-therapy-in-patients-with-takayasu-arteritis-with-low-dose-of-glucocorticoids-a-prospective-single-arm-study
#1
Eun Hye Park, Eun Young Lee, Yun Jong Lee, You Jung Ha, Wan-Hee Yoo, Byoong Yong Choi, Jin Chul Paeng, Hoon Young Suh, Yeong Wook Song
To evaluate the efficacy and safety of infliximab biosimilar CT-P13 in patients with active Takayasu arteritis (TAK). In this single-center open-label trial, patients with active TAK received CT-P13 at a starting dose of 5 mg/kg at weeks 0, 2, 6, and then every 8 weeks up to week 46. They were followed up until week 54. From week 14 to week 46, patients with inadequate response received increased dose of CT-P13 by 1.5 mg/kg. Concomitant prednisolone was allowed ≤ 10 mg/day. The primary efficacy end point was the achievement of partial or complete remission at week 30...
September 18, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30225658/assessment-of-nail-unit-structures-by-ultrasound-in-patients-with-psoriatic-arthritis-and-their-correlations-with-disease-activity-indices-a-case-control-study
#2
Sumantro Mondal, Satarupa Dutta, Debasish Lahiri, Debanjali Sinha, Geetabali Sircar, Ashok Kumar Mandal, Megha Kejriwal, Alakendu Ghosh
Ultrasound (USG) of nail was performed to assess, (1) morphological alterations of nail plates in psoriatic arthritis (PsA) patients, (2) differences of nail unit parameters [nail bed thickness (NBT), nail matrix thickness (NMT) and nail plate distance (NPD)] in PsA patients from healthy controls (3) correlation of nail unit parameters with PsA disease activity indices. Total of 895 fingernails (448 nails of 45 PsA patients and 447 of 45 controls) were evaluated by USG. Psoriasis Area and Severity Index (PASI), Disease Activity in Psoriatic Arthritis (DAPSA), and Nail Psoriasis Severity Index (NAPSI) were calculated in PsA patients...
September 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30221327/diagnosis-and-differential-diagnosis-of-large-vessel-vasculitides
#3
REVIEW
Gokhan Keser, Kenan Aksu
There are no universally accepted diagnostic criteria for large-vessel vasculitides (LVV), including giant cell arteritis (GCA) and Takayasu arteritis (TAK). Currently, available classification criteria cannot be used for the diagnosis of GCA and TAK. Early diagnosis of these two diseases is quite challenging in clinical practice and may be accomplished only by combining the patient symptoms, physical examination findings, blood test results, imaging findings, and biopsy results, if available. Awareness of red flags which lead the clinician to investigate TAK in a young patient with persistent systemic inflammation is helpful for the early diagnosis...
September 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30218145/using-google-trends-to-assess-global-public-interest-in-osteoarthritis
#4
Samuel S Jellison, Michael Bibens, Jake Checketts, Matt Vassar
To evaluate global public interest in osteoarthritis by assessing changes in Internet search popularity of the disease over a 10-year period. Google Trends was used to obtain search popularity scores for the word "osteoarthritis" (OA) between January 2004 and June 2018. We also analyzed changes in search volume relative to changes in search patterns for all health topics. Search interest in OA was high relative to all other health searches over the given timeframe. Overall, searches for OA steadily decreased between May 2004 and December 2012 and then steadily rose from January 2013 to April 2018...
September 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30206672/high-burden-of-skin-sclerosis-is-associated-with-severe-organ-involvement-in-patients-with-systemic-sclerosis-and-systemic-sclerosis-overlap-syndrome
#5
Thapat Wannarong, Chayawee Muangchan
The objective of this study is to investigate the impact of skin sclerosis burden on an internal organ involvement over a 1-year period, as measured by time-adjusted accrual-modified Rodnan skin score (TA-mRSS), and to evaluate association between TA-mRSS patterns and laboratory tests in patients with systemic sclerosis (SSc). This prospective study was conducted at Siriraj Hospital (Bangkok, Thailand) during the November 2013-November 2016. SSc patients by ACR/EULAR 2013 or ACR 1980 criteria were eligible...
September 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30206671/sleep-impairment-an-obstacle-to-achieve-optimal-quality-of-life-in-rheumatoid-arthritis
#6
REVIEW
Ilke Coskun Benlidayi
Sleep impairment is a common clinical condition in patients with rheumatoid arthritis. There are several confounding factors for poor sleep quality including inflammation, pain, comorbidities, and medications. Consequences of impaired sleep vary within a wide spectrum, as well. These include exacerbated inflammation and inflammation-related symptoms, mental and physical fatigue, mood disorders, daytime sleepiness, and poor quality of life. Sleep impairment in rheumatoid arthritis and its association with disease-related variables including health-related quality of life have been studied several times in the literature...
September 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30206670/efficacy-and-safety-of-extending-intravenous-tocilizumab-intervals-from-4-to-6-weeks-in-rheumatoid-arthritis-patients-with-good-response-to-4-week-intervals
#7
Osamu Saiki, Hiroshi Uda
A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between intravenous (IV) tocilizumab (TCZ, 8 mg/kg). In a previous paper, we showed the possibility that the interval between successive IV TCZ can be extended from 4 to 6 weeks in more than 60% of patients with low diseases activity (LDA) at 4-week intervals. Herein, we aimed to investigate the efficacy and safety of extending the interval from 4 to 6 weeks. A retrospective observational study was conducted by enrolling patients in whom the intervals of TCZ infusions could be extended from 4 to 6 weeks with an LDA for more than 2 years...
September 11, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30203113/long-term-effects-of-tacrolimus-for-maintenance-therapy-of-lupus-nephritis-a-5-year-retrospective-study-at-a-single-center
#8
Kazunori Karasawa, Keiko Uchida, Mio Kodama, Takahito Moriyama, Kosaku Nitta
Previously, we reported the short-term effects of tacrolimus in treating lupus nephritis (LN); however, long-term data are lacking. We conducted a retrospective study of 26 adult patients with LN. Tacrolimus was initiated at a dose of 3 mg/day after induction therapy. We retrospectively collected data on renal response; modified lupus nephritis disease activity index (m-LNDAI), including hematuria, proteinuria, complement 3, anti-double-stranded DNA antibody, and estimated glomerular filtration rate (eGFR); and prednisolone (PSL) dose...
September 10, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30194455/gender-does-not-make-a-difference-in-composite-psoriatic-disease-activity-index-cpdai-in-patients-with-psoriatic-arthritis
#9
Gökçe Kenar, Handan Yarkan, Berrin Zengin, Gerçek Can, Merih Birlik, Fatoş Önen
The aim of the study was to investigate the relationship of CPDAI with other follow-up parameters and to evaluate gender differences in measures in psoriatic arthritis (PsA) patients. This cross-sectional study included patients with PsA followed up at a rheumatology outpatient clinic. Disease activity was assessed using CPDAI, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Visual Analog Scale (VASglobal ) and Disease Activity Score (DAS28). Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were measured...
September 8, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30187141/correction-to-sleep-and-physical-activity-a-cross-sectional-objective-profile-of-people-with-rheumatoid-arthritis
#10
Sean McKenna, Marie Tierney, Aoife O'Neill, Alexander Fraser, Norelee Kennedy
The original article can be found online.
September 5, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30182290/clinical-presentation-treatment-and-outcome-of-takayasu-s-arteritis-in-southern-chinese-a-multicenter-retrospective-study
#11
Stella Pui Yan Wong, Chi Chiu Mok, Chak Sing Lau, Man Lung Yip, Lai Shan Tam, King Yee Ying, Woon Leung Ng, Kam Hung Ng, Moon Ho Leung, Tsz Yan Lee, Chi Hung To, Ka Lai Lee, Man Choi Wan, Ka Lung Yu, Priscilla Ching Han Wong, Chi Keung Sung, Kwok Fai Lee, Emily Wai Lin Kun
To study the clinical presentation, treatment and outcome of southern Chinese patients with Takayasu's arteritis (TA). This is a retrospective chart review study of 78 patients managed in 14 public hospitals in Hong Kong between the years 2000 and 2010. Patients were identified from the hospital registry using the ICD-10 diagnostic code of the disease. The classification of TA was based on the American College of Rheumatology (ACR) or modified Ichikawa's criteria. Demographic data, clinical presentation, angiographic findings, pattern of vascular involvement (Numano's classification), treatment and outcome of these patients were presented...
September 4, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30171342/comparison-of-different-treatment-approaches-of-pediatric-chronic-non-bacterial-osteomyelitis
#12
Mikhail M Kostik, Olga L Kopchak, Irina A Chikova, Eugenia A Isupova, Alexander Y Mushkin
Chronic non-bacterial osteomyelitis (CNO) is a chronic inflammatory bone disease which usually manifests in children and adolescents. There are a few data about pathogenesis and treatment. The aim of the study to compare the efficacy of different treatment approaches in pediatric CNO cohort patient. Fifty two children (25 boys and 27 girls) with CNO with average age at the onset of the disease 8.4 years (5.4; 11.0), number of foci - 3.0 (2.0; 6.0, incl. multifocal cases in 80.8%). Non-steroid anti-inflammatory drugs (NSAID) was the first-line treatment for non-vertebral cases, as well as pamidronate (PAM) for vertebral involvement...
August 31, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30171341/comparative-study-of-shockwave-therapy-and-low-level-laser-therapy-effects-in-patients-with-myofascial-pain-syndrome-of-the-trapezius
#13
Márta Király, Tamás Bender, Katalin Hodosi
The objective of the study was to compare the effects of shockwave therapy and laser therapy on pain, neck functionality, and quality of life in patients with myofascial pain syndrome of the trapezius. 61 patients (> 18 years) were randomly allocated to two treatment groups: (1) 31 patients received soft laser therapy once daily in a 3-week period for a total of 15 sessions, (2) 30 patients received shockwave therapy once in a week for 3 weeks, totalling 3 treatments. Resting pain and pain tolerance were assessed by a 100 mm visual analogue scale; functional status and quality of life were measured by specific questionnaires (Neck Disability Index, SF-36) before and after the 3-week therapy and at the 15th week follow-up visit...
August 31, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30167765/validation-and-cultural-adaptation-of-the-qualisex-questionnaire-in-patients-with-axial-spondyloarthritis-in-argentina
#14
Fernando Andres Sommerfleck, Emilce Edith Schneeberger, Maria Celeste Orozco, Natalia Zamora, Margarita Landi, Gustavo Citera
The Qualisex questionnaire was developed and validated to assess sexuality in patients with rheumatoid arthritis. To the best of our knowledge, there is no instrument to evaluate sexuality in axial spondyloarthritis (axSpA). For this reason, the objective of this study was to validate and adapt the Qualisex questionnaire in axSpA and evaluate the impact of the disease on patients' sexuality. Cross sectional study. Consecutive patients, with ≥ 21 years of age, diagnosed with axSpA according to ASAS'09 criteria were included...
August 30, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30159775/proton-pump-inhibitors-use-and-risk-of-hip-fracture-a-systematic-review-and-meta-analysis
#15
REVIEW
Salman Hussain, Ali Nasir Siddiqui, Anwar Habib, Md Sarfaraj Hussain, Abul Kalam Najmi
In the last decade, epidemiological studies presented inconsistent findings concerning the proton pump inhibitors (PPI) use and the risk of hip fracture. So, this systematic review and meta-analysis were performed with the aim to quantify the risk of hip fracture associated with PPI use. PubMed® and Cochrane Central databases were searched from inception to January 2018. The quality of included studies in meta-analysis was assessed using Newcastle-Ottawa scale. Primary outcome of this study was to assess the risk of hip fracture among PPI user...
August 29, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30159774/associations-between-fatigue-and-physical-capacity-in-people-moderately-affected-by-rheumatoid-arthritis
#16
Ingrid Demmelmaier, Susanne Pettersson, Birgitta Nordgren, Alyssa B Dufour, Christina H Opava
To explore the contribution of physical capacity in explaining variations in fatigue among people with rheumatoid arthritis (RA). This study included participants recruited for a physical activity intervention. Data were collected from the Swedish Rheumatology Quality Registers, from questionnaires on fatigue, activity limitation, perceived health, pain and anxiety/depression and from physical capacity tests (lower limb function, grip strength, and aerobic capacity). We used logistic regression to estimate the association between severe fatigue (≥ 50, visual analogue scale 0-100) and (A) independent variables related to disease and disease impact and (B) model A plus physical capacity tests...
August 29, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30143819/elevated-ca-125-in-igg4-mesenteritis-a-red-herring-or-a-disease-biomarker-case-report-and-literature-review
#17
REVIEW
Mailis Michaud Maturana, Ismini Panayotidis, Savvas Psarelis, George Nakos, Elena Nikiphorou
Mesenteric panniculitis (MP) is a rare chronic disease characterized by inflammation and subsequently fibrosis of adipose tissue of the omentum. Only recently it has been associated with IgG4-related disease. Cancer antigen 125 (CA-125) is a high-molecular mass glycoprotein, traditionally associated with ovarian cancer, although it can be elevated in other conditions. Herein we describe a case of a 56-year-old man with IgG4 related mesenteric panniculitis associated with very high levels of CA-125 at the onset of disease...
August 24, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30143818/long-term-etanercept-survival-in-patients-with-psoriatic-arthritis-a-multicenter-retrospective-analysis-in-daily-clinical-practice-in-spain
#18
Gustavo Deza, Jaime Notario, Marta Ferran, Emma Beltrán, Miriam Almirall, Rebeca Alcalá, José Carlos Ruiz-Carrascosa, Ricardo Sánchez, Silvia Pérez, María Luz García-Vivar, Eva Galíndez, Maribel Mora, Jesús Rodríguez, Fernando Gallardo
Although several randomized clinical trials and observational studies have evaluated the effectiveness, safety and drug survival of etanercept (ETN) in the treatment of psoriatic arthritis (PsA), long-term data regarding these aspects are currently scarce. For this reason, we sought to investigate the long-term survival and safety of ETN in PsA patients in 4 tertiary care Spanish hospitals over a 13-year observation period (from 2004 to 2017). The records of 85 PsA patients were reviewed. ETN showed an excellent survival profile, with rates of treatment discontinuation at 1, 3, 5 and 10 years of 15, 37, 46 and 59%, respectively...
August 24, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30155667/non-pharmacological-options-for-managing-chronic-musculoskeletal-pain-in-children-with-pediatric-rheumatic-disease-a-systematic-review
#19
REVIEW
Linde N Nijhof, Merel M Nap-van der Vlist, Elise M van de Putte, Annet van Royen-Kerkhof, Sanne L Nijhof
In patients with a pediatric rheumatic disease (PRD), chronic musculoskeletal pain (CMP) can have a major impact on functioning and social participation. Because CMP is not always alleviated solely by the use of pharmacological approaches, the aim was to systematically review the available evidence regarding non-pharmacological treatment options for reducing CMP in patients with PRD. PubMed, Embase, PsycINFO, and the Cochrane Library were systematically searched for (non-)randomized trials investigating non-pharmacological treatments for CMP in PRD published through October 25, 2017...
August 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30155666/renal-involvement-in-primary-sjogren-s-syndrome-a-prospective-cohort-study
#20
Ankit Jain, Bheemanathi Hanuman Srinivas, Dantis Emmanuel, Vikramraj K Jain, Sreejith Parameshwaran, Vir Singh Negi
The objective of the study is to prospectively evaluate the spectrum of clinical and subclinical renal involvement in patients with primary Sjogren's syndrome (pSS). Of the 174 patients screened, seventy patients with pSS underwent renal function tests, urine examination, renal ultrasound, arterial blood gases, urine pH followed by urine acidification test and renal biopsy (if indicated). Renal tubular acidosis (RTA) was treated with alkali replacement and moderate-severe tubulointerstitial nephritis (TIN) was treated with oral prednisolone...
August 23, 2018: Rheumatology International
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