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Rheumatology International

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https://www.readbyqxmd.com/read/28224216/vascular-surgery-the-main-risk-factor-for-mortality-in-146-takayasu-arteritis-patients
#1
Nilton Salles Rosa Neto, Samuel Katsuyuki Shinjo, Maurício Levy-Neto, Rosa Maria Rodrigues Pereira
Takayasu arteritis (TA) is an idiopathic chronic inflammatory disease that affects the aorta and its main branches. According to disease involvement, patients may require surgical treatment mainly due ischemic lesions in association with medical therapy. We evaluated the impact of vascular interventions in a cohort of TA patients. Medical records from 146 TA patients were reviewed. Clinical features, medical, and surgical treatment were revised and disease activity was determined by clinical, laboratorial, and imaging parameters...
February 21, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28214924/characteristics-and-outcomes-of-rheumatoid-arthritis-patients-who-started-biosimilar-infliximab
#2
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Soyoung Won, Chan-Bum Choi, So-Young Bang, Seung-Jae Hong, Hyoun Ah Kim, Eun-Mi Koh, Hye-Soon Lee, Chang-Hee Suh, Dae-Hyun Yoo, Sang-Cheol Bae
To compare the characteristics of rheumatoid arthritis (RA) patients receiving either biosimilar or originator infliximab and to identify the effectiveness and safety of biosimilar infliximab in RA patients in real-world practice. RA patients who started either biosimilar or originator infliximab were selected using the prospective biologic disease-modifying anti-rheumatic drugs (DMARDs) registry: BIOlogics Pharmacoepidemiologic StudY (BIOPSY). Baseline characteristics of the two groups were compared, and short-term treatment outcomes, including DAS28-ESR and HAQ-DI scores, were compared after initiation of biosimilar or originator infliximab...
February 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28214923/urinary-free-light-chains-may-help-to-identify-infection-in-patients-with-elevated-systemic-inflammation-due-to-rheumatic-disease
#3
Carsten P Bramlage, Britta Froelich, Manuel Wallbach, Joan Minguet, Clemens Grupp, Cornelia Deutsch, Peter Bramlage, Gerhard A Müller, Michael Koziolek
The risk of infection in patients with rheumatic diseases is elevated, but a clear marker to differentiate the cause of the systemic inflammation is missing. We assessed the ability urinary immunoglobulin free light chains (FLCs) to indicate the presence of infection in patients with rheumatic disease. We performed a retrospective analysis of patients with rheumatic disease attending the Georg-August University Hospital in Goettingen, Germany, from January 2011 to December 2013. Subjects were included if they had urine levels of κ and λ FLCs available...
February 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28213637/successful-treatment-of-prokinetic-resistant-intestinal-pseudo-obstruction-and-pneumatosis-cystoides-intestinalis-in-systemic-sclerosis-with-metronidazole
#4
LETTER
Masaaki Fujita, Yumiko Nakano, Masato Yagita
No abstract text is available yet for this article.
February 17, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28197718/adaptation-of-the-osteoarthritis-specific-quality-of-life-scale-the-oaqol-for-use-in-germany-hungary-italy-spain-and-turkey
#5
Jeanette Wilburn, Stephen P McKenna, Şehim Kutlay, Tamas Bender, Jürgen Braun, Concepcion Castillo-Gallego, Marta Favero, Pal Geher, Uta Kiltz, Emilio Martin-Mola, Roberta Ramonda, Matthew Rouse, Alan Tennant, Ayşe A Küçükdeveci
The Osteoarthritis Quality of Life scale (OAQoL) is specific to individuals with osteoarthritis. The present study describes the adaptation of the OAQoL for use in the following five European languages: German, Hungarian, Italian, Spanish and Turkish. The study involved three stages in each language; translation, cognitive debriefing (face and content validity) and validation. The validation stage assessed internal consistency (Cronbach's alpha), reproducibility (test-retest reliability using Spearman's rank correlations), convergent and divergent validity (correlations with the Health Assessment Questionnaire, The Western Ontario and McMaster Universities Index of osteoarthritis and Nottingham Health Profile) and known group validity...
February 15, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28184992/association-study-between-the-tp53-rs1042522g-c-polymorphism-and-susceptibility-to-systemic-lupus-erythematosus-in-a-chinese-han-population
#6
Jie Yang, Ji-Min Zhu, Song Wu, Jing Li, Ming-Rui Wang, Ting-Ting Wang, Yu-Wei Lu
Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. This case-control study enrolled 1470 SLE patients and 2283 healthy controls. The genotyping of TP53 rs1042522 polymorphism was determined by Sequenom Mass ARRAY technology...
February 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28180909/cognitive-impairment-in-women-with-joint-hypermobility-syndrome-ehlers-danlos-syndrome-hypermobility-type
#7
LETTER
Carolina Baeza-Velasco, Caroline Bourdon, Roberto Polanco-Carrasco, Marie de Jouvencel, Marie-Christine Gely-Nargeot, Anne Gompel, Claude Hamonet
No abstract text is available yet for this article.
February 8, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28175955/associations-between-c677t-and-a1298c-polymorphisms-of-mthfr-and-susceptibility-to-rheumatoid-arthritis-a-systematic-review-and-meta-analysis
#8
Yi Yuan, Wenjing Shao, Yuying Li
Methylenetetrahydrofolatereductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis. Although a number of studies have examined the association of the MTHFR C677T and A1298C polymorphisms with susceptibility to rheumatoid arthritis (RA), the conclusions are controversial. A comprehensive literature search using PubMed, Embase, the Cochrane Library, CNKI and Wanfang databases was conducted for relevant studies on the association between MTHFR polymorphisms and RA risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- and random-effect models...
February 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28168545/prevalence-of-musculoskeletal-disorders-in-azar-cohort-population-in-northwest-of-iran
#9
Sousan Kolahi, Alireza Khabbazi, Aida Malek Mahdavi, Amid Ghasembaglou, Arezoo Ghasembaglou, Nayyereh Aminisani, Mohammad Hossein Somi, Fariba Heidari
Musculoskeletal disorders (MSDs) are considered as major public health problems. The purpose of this study was to determine the prevalence of MSDs in Azar cohort population in northwest of Iran. Azar cohort study is a state level of a national cohort project (PERSIAN) which began in 2014. All adults over 35 years old in Khamene city in East Azarbaijan province were recruited for the pilot phase of the Azar cohort. For the purpose of the current study, a total of 952 subjects age range of 35-70 who completed the Community Oriented Program for the Control of Rheumatic Disease (COPCORD) questionnaire as supplementary were included...
February 6, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28160072/systemic-sclerosis-with-anti-rna-polymerase-iii-positivity-following-silicone-breast-implant-rupture-possible-role-of-b-cell-depletion-and-implant-removal-in-the-treatment
#10
REVIEW
Francesca Dall'Ara, Maria-Grazia Lazzaroni, Chiara M Antonioli, Paolo Airò
Despite some case reports and small series of women with silicone breast implants (SBI) developing Systemic Sclerosis (SSc), no clear evidence of an association of SBI with SSc is available. However, SSc is characterized by clinical and immunological heterogeneity and autoantibodies are currently the best markers to stratify this heterogeneity of patients. Therefore, we have reviewed the literature for details of autoantibody characterization in reports of SSc associated with SBI. Moreover, the case of an anti-RNA polymerase III-positive SSc with rapid onset and progression, in which SBI rupture was found is described...
February 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28160071/adherence-to-combination-dmard-therapy-and-treatment-outcomes-in-rheumatoid-arthritis-a-longitudinal-study-of-new-and-existing-dmard-users
#11
Nasir Wabe, Anita Lee, Mihir Wechalekar, Leah McWilliams, Susanna Proudman, Michael Wiese
Medication adherence is believed to be a major contributor to treatment outcomes yet studies quantifying this relationship as rare in rheumatoid arthritis (RA). To determine the association of adherence to DMARD therapy with treatment outcomes among new and existing DMARD users over 2 years. Relevant clinical parameters were obtained from a longitudinal cohort of RA patients, most of who were treated with combination therapy. Patients were classified as adherent if the proportion of days covered for each DMARD was ≥80%...
February 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28160070/single-nucleotide-polymorphisms-of-il12b-are-associated-with-takayasu-arteritis-in-chinese-han-population
#12
Xiaoting Wen, Si Chen, Ping Li, Jing Li, Ziyan Wu, Yuan Li, Liubing Li, Hui Yuan, Xinping Tian, Fengchun Zhang, Yongzhe Li
Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SNPs) reported in these studies are associated with TA in the Chinese Han population. A multi-center study involving 412 patients with TA and 597 healthy controls was conducted. Sequenom MassArray iPLEX platform was used to determine the frequencies of SNPs in the IL12B and IL6 region...
February 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28154899/baseline-increased-18f-fluoride-uptake-lesions-at-vertebral-corners-on-positron-emission-tomography-predict-new-syndesmophyte-development-in-ankylosing-spondylitis-a-2-year-longitudinal-study
#13
Eun-Kyoung Park, Kyoungjune Pak, Ji-Heh Park, Keunyoung Kim, Seong-Jang Kim, In-Joo Kim, Geun-Tae Kim, Seung-Geun Lee
The goal of this study was to demonstrate whether increased 18F-fluoride uptake lesions on positron emission tomography (PET) scan can predict new syndesmophyte development in patients with ankylosing spondylitis (AS). In 12 AS patients, 18F-fluoride PET and magnetic resonance imaging (MRI) was performed at baseline, and radiography was performed at baseline and the 2-year follow-up. The following data were recorded: the presence of increased 18F-fluoride uptake lesions on PET defined as an uptake greater than the uptake in the adjacent normal vertebral body; acute (type A) and advanced (type B) corner inflammatory lesions (CILs) and fat lesions on MRI; and syndesmophytes on radiography...
February 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28154898/p-glycoprotein-gene-mdr1-polymorphisms-and-susceptibility-to-systemic-lupus-erythematosus-in-guangxi-population-a-case-control-study
#14
Jian Wang, Yanqiong Liu, Jiangyang Zhao, Juanjuan Xu, Shan Li, Xue Qin
The multidrug resistance 1 gene (MDR1) encodes for P-glycoprotein (P-gp), which plays a pathophysiological role in the development of autoimmune diseases, including systemic lupus erythematosus (SLE). Herein, we aimed to investigate the relationship between MDR1 gene polymorphisms and SLE susceptibility in the Chinese Guangxi population. The genotypes of rs1128503 and rs1045642 in MDR1 gene were analyzed using the polymerase chain reaction-restriction fragment length polymorphism method in 283 SLE patients and 247 healthy controls from Guangxi...
February 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28132103/polymorphisms-in-the-multidrug-resistance-1-gene-related-to-glucocorticoid-response-in-rheumatoid-arthritis-treatment
#15
Bart V J Cuppen, Katerina Pardali, Maarten C Kraan, Anne C A Marijnissen, Linda Yrlid, Marita Olsson, Johannes W J Bijlsma, Floris P J G Lafeber, Ruth D E Fritsch-Stork
A substantial proportion of rheumatoid arthritis (RA)-patients experience an insufficient response to glucocorticoids, an important therapeutic agent in RA. The multidrug-resistance 1 (MDR1) gene product P-glycoprotein (P-gp) is an efflux pump that actively transports substrates, such as glucocorticoids, out of the cell. We investigated if the variation in response might be explained by single-nucleotide polymorphisms (SNPs) in the MDR1 gene. RA-patients treated with intravenous methylprednisolone pulses (n = 18) or oral prednisone/prednisolone (n = 22) were included in a prospective cohort, and clinical response was measured after 5 and 30 days, respectively...
January 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28132102/comparative-effectiveness-of-treatment-options-after-conventional-dmards-failure-in-rheumatoid-arthritis
#16
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Hyoun Ah Kim, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Yeon-Ah Lee, Seong-Su Nah, Chang-Hee Suh, Dae-Hyun Yoo, Bo Young Yoon, Sang Cheol Bae
OBJECTIVE: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs. METHODS: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs. As a control group, we selected RA patients with moderate or high disease activity from the KORONA database whose treatment was changed to other csDMARDs...
January 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28132101/sonographic-characterization-of-hoffa-s-fat-pad-a-pilot-study
#17
Erika Vera-Pérez, Guadalupe Sánchez-Bringas, Lucio Ventura-Ríos, Cristina Hernández-Díaz, Socorro Cortés, Marwin Gutiérrez, Carlos Pineda
This study addresses a topic that was previously unaddressed in the literature: the normal sonographic appearance of the Hoffa's fat pad (HFP) in young, asymptomatic subjects. The aim of the study is to describe the sonoanatomical features of HFP, including its echostructure, echogenicity, elasticity, and vascularization, in subjects without knee pathology. Knees of healthy subjects were examined with grayscale ultrasound (US) to determine the sonographic characteristics of the HFP. Echogenicity was assessed by pixel intensity quantification...
January 28, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28124095/pain-social-support-and-depressive-symptoms-in-patients-with-rheumatoid-arthritis-testing-the-stress-buffering-hypothesis
#18
Susanne Brandstetter, Gertraud Riedelbeck, Mark Steinmann, Boris Ehrenstein, Julika Loss, Christian Apfelbacher
This study investigated as to how social support influences health among people with rheumatoid arthritis (RA). We refer to the stress-buffering hypothesis of social support which suggests that the negative consequences of stressors on health outcomes can be buffered by social support. In this study, pain represents a stressor and depressive symptoms represent negative health outcomes. It was hypothesized that higher levels of social support should attenuate the association between pain and depression in RA...
January 25, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28124094/pain-rather-than-self-reported-sedentary-time-explains-variation-in-perceived-health-and-activity-limitation-in-persons-with-rheumatoid-arthritis-a-cross-sectional-study-in-sweden
#19
Ingrid Demmelmaier, Pernilla Åsenlöf, Patrick Bergman, Birgitta Nordgren, Christina H Opava
: To investigate (1) the amount of self-reported time spent sedentary among a large cohort of persons with rheumatoid arthritis (RA), and (2) the contribution of sedentary time to explain perceived health and activity limitation in RA beyond that of previously known correlates. This cross-sectional study used data from a postal questionnaire and the Swedish Rheumatology Quality registers (SRQ). The International Physical Activity Questionnaire was used to assess sedentary time (sitting) and moderate, vigorous and walking activity (MVPA)...
January 25, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28108765/score-study-quality-indicators-for-rheumatology-nursing-clinics
#20
Santiago Muñoz-Fernández, Ma Dolores Aguilar, Raquel Almodóvar, Laura Cano-García, Sandra Fortea, Cristina Patricia Alcañiz-Escandell, José R Rodríguez, Laura Cebrián, Pablo Lázaro
Nursing clinics in rheumatology (NCR) are organizational care models that provide care centred within the scope of nurses abilities. To analyse patients differences in the knowledge of the disease, adherence to the treatment, quality indicators of the Rheumatology Departments included quality perceived by the patients with and without NCR. National multicenter observational prospective cohort study 1 year follow-up, comparing patients attending rheumatology services with and without NCR. NCR was defined by the presence of: (1) office itself; (2) at least one dedicated nurse; (3) its own appointment schedule, and (4) phone...
January 20, 2017: Rheumatology International
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