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Rheumatology International

Massimo Varenna, Chiara Crotti
Complex Regional Pain Syndrome type 1 (CRPS-1) is a disabling painful disease whose hallmark is pain disproportionate to inciting event. CRPS is also characterized by symptoms and signs, such as vasomotor, sudomotor, trophic and motor changes. Therapeutic approach of CRPS-1 still remains a challenge for clinicians treating a disease with potential heavy consequences on patient prognosis. In the past years, the treatment with bisphosphonates (BPs) has gained some success as confirmed by the results of a number of meta-analyses...
July 14, 2018: Rheumatology International
Ilke Coskun Benlidayi, Neslihan Gokcen, Sibel Basaran
The objective of the present study was to compare the effectiveness of gel and cream ibuprofen phonophoresis in patients with knee osteoarthritis. A single-blinded, randomized, comparative design was applied. Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria were included in the study. After obtaining written informed consent, patients were randomized into ibuprofen gel and cream phonophoresis groups. Each patient was treated five sessions per week for 2 weeks (ten sessions)...
July 12, 2018: Rheumatology International
Hannes Kubo, Prasad Thomas Oommen, Martin Hufeland, Philipp Heusch, Hans-Juergen Laws, Ruediger Krauspe, Hakan Pilge
Juvenile osteochondritis dissecans (JOCD) and juvenile idiopathic arthritis (JIA) are both common diseases which may affect joints and bony structures in pediatric patients. In some cases, JOCD and JIA occur at the same time. In this study, the course of JOCD in patients with JIA was therefore evaluated to provide possible recommendations for further treatment opportunities and control examinations. From 06/2012 to 03/2018 55 children with JOCD with or without JIA were examined. Inclusion criteria were: (1) age ≤ 16 years, (2) diagnosis of a JOCD with or without JIA and (3) two routine MRI controls...
July 10, 2018: Rheumatology International
Francis Fatoye, Tadesse Gebrye, Lawrence W Svenson
Systemic lupus erythematosus (SLE) is rather uncommon than rare. The purpose of this study was to estimate the incidence and prevalence of SLE in the population of Alberta, Canada, using administrative health data. Multiple population-based data sources, including the Alberta Health Care Insurance Plan Central Stakeholder Registry (AHCIP CSR), Fee-For-Service, and Hospital Discharge Abstract Database were used. Age- and sex-specific incidence and prevalence rates, and 95% confidence intervals (CI), were computed using the AHCIP CSR mid-year population estimates as the denominator, for the period of 2000-2015...
July 9, 2018: Rheumatology International
Tamami Yoshida, Motomu Hashimoto, Rie Kawahara, Hiroko Yamamoto, Masao Tanaka, Hiromu Ito, Izuru Masuda, Kiminori Hosoda, Wataru Yamamoto, Ryuji Uozumi, Satoshi Morita, Yasutomo Fujii, Tsuneyo Mimori, Kazuko Nin
Rheumatoid arthritis (RA) patients often have altered body composition including reduced muscle mass and increased fat mass. Some RA patients are likely to increase visceral fat without obesity [Body Mass Index (BMI) ≥ 25]. The objective of the study was to determine the association between obesity and/or visceral adiposity and the risk for atherosclerosis in Japanese RA patients. Obesity was evaluated using the BMI, with visceral adiposity evaluated using the visceral fat area (VFA) and the visceral/subcutaneous fat ratio (V/S ratio), quantified using the dual bioelectrical impedance method...
July 4, 2018: Rheumatology International
Ahmet Üşen
No abstract text is available yet for this article.
July 4, 2018: Rheumatology International
Ignazio Olivieri, Massimo Accorinti, Irene Abicca, Paola Bisceglia, Luca Cimino, Loredana Latanza, Pietro Leccese, Ennio Lubrano, Antonio Marchesoni, Elisabetta Miserocchi, Piergiorgio Neri, Carlo Salvarani, Raffaele Scarpa, Salvatore D'Angelo
Ocular involvement is a common manifestation of inflammatory rheumatic diseases, often requiring a multidisciplinary collaboration between rheumatologists and ophthalmologists. The aim of this study was to standardize "red flags" for referral for rheumatologists and ophthalmologists using a Delphi consensus for the management of rheumatic diseases with ocular involvement. The scientific board comprised 11 Italian hospital-based rheumatologists (N = 6) and ophthalmologists (N = 5). A systematic review identified potential red flags for referral...
June 30, 2018: Rheumatology International
Luis Cea-Calvo, Enrique Raya, Carlos Marras, Tarek C Salman-Monte, Ana Ortiz, Georgina Salvador, Indalecio Monteagudo, Loreto Carmona, Sabela Fernandez, Maria J Arteaga, Jaime Calvo-Allén
Patients' beliefs about their prescribed medication are an important factor influencing intentional non-adherence. This study describes rheumatoid arthritis (RA) patients' beliefs about their subcutaneous (SC) biological medication through the Beliefs about Medicines Questionnaire (BMQ), and potential associations. As part of the ARCO study (Study on Adherence of Rheumatoid arthritis patients to subCutaneous and Oral drugs), patients completed the BMQ specifically for their SC biological medication, encompassing a necessity and a concerns scale...
June 29, 2018: Rheumatology International
Yoon-Jin Cho, Wun-Yong Jung, Sang-Yoep Lee, Ji-Sun Song, Hee-Jin Park
Immunoglobulin G4-related disease (IgG4-RD) is a chronic, immune-mediated-, systemic disease that is characterized by IgG4 plasma cell infiltration with fibrotic changes in various organs. The most affected organs are pancreas and salivary glands. Kidney can be rarely involved, and is usually represented as a renal mass and organomegaly. Usually, elevated levels of serum IgG4 more than 135 mg/dl with organ-specific features and biopsy results showing enriched infiltration of IgG4-positive plasma cells are needed to diagnose the disease...
June 29, 2018: Rheumatology International
Fausto Salaffi, Marco Di Carlo, Marina Carotti, Piercarlo Sarzi-Puttini
To determine the contribution of fibromyalgia (FM) to the subjective components of the Disease Activity Score 28-joints (DAS28) in patients with rheumatoid arthritis (RA), and to analyse the discriminatory performance of the derived DAS28 patient-reported components (DAS28-P) to identify patients with fibromyalgic RA. Consecutive RA patients underwent clinical and clinimetric assessment. The DAS28-P index was derived from the components of the DAS28 scores by rearranging the DAS28-ESR formula. Patients were distinguished by the presence of FM...
June 28, 2018: Rheumatology International
Özge Başaran, Nermin Uncu, Nilgün Çakar, Eda Tahir Turanlı, Saba Kiremitci, Fatma Aydın, Umut Selda Bayrakcı
Autoinflammatory diseases (AIDs) are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes (CAPS) are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticarial syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID). CAPS have been associated with gain-of-function variations in NLRP3 (NOD-like receptor family, pyrin containing domain-3)...
June 27, 2018: Rheumatology International
Zahide Ekici Tekin, Gülçin Otar Yener, Selçuk Yüksel
An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease. We report a previously healthy 16-year-old girl with an acquired angioedema as a rare and initial presentation of systemic lupus erythematosus. The patient had no previous angioedema attack and no family history. She did not have any chronic diseases and did not use any medicine regularly. The patient was diagnosed with systemic lupus erythematosus with the presence of polyarthralgia, angioedema, leucopenia, and positivity of immunologic criteria...
June 27, 2018: Rheumatology International
Dario Camellino, Stefano Soldano, Maurizio Cutolo, Marco A Cimmino
The efficacy of tocilizumab (TCZ), a monoclonal antibody to the interleukin (IL)-6 receptor, in suppressing disease activity in glucocorticoid-naïve patients with new-onset polymyalgia rheumatica (PMR) was studied. Its effect on a panel of cytokines and growth factors was evaluated. Three patients, fulfilling the PMR ACR/EULAR criteria, received TCZ at the dosage of 8 mg/kg every 4 weeks for three times followed by prednisone 0.2 mg/kg in case of inefficacy. Concentrations of IL-10, IL-6, tumour necrosis factor (TNF)-α, IL-1β, IL-10, IL-17, interferon (IFN)-γ, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and leukaemia inhibitory factor (LIF) were measured at baseline, after 72 h of the first TCZ infusion and then at weeks 1, 4, 5, 8, 9, 12, 13, 14, 16, and 22...
June 26, 2018: Rheumatology International
Bilge Basakci Calik, Elif Gur Kabul, Harun Taskın, Orcin Telli Atalay, Ummuhan Bas Aslan, Murat Tascı, Fahrettin Bıcakcı, Ali Ihsan Yıldız
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease affecting mainly the axial skeleton and sacroiliac joints. The aim of the current study was to investigate the effects of inspiratory muscle training (IMT) on respiratory muscles and functional exercise capacity, as well as on the specific outcomes of the disease in AS patients. A total of 32 AS patients (mean age 37.37 ± 10.41 years) were randomly assigned as the Training Group (TG) (n = 16, mean age = 35.62 ± 8.18 years) who received IMT + conventional exercise, and the Control Group (CG) (n = 16, mean age = 39...
June 25, 2018: Rheumatology International
Mark D Russell, Thomas R Barrick, Franklyn A Howe, Nidhi Sofat
OBJECTIVE: Increasing evidence supports the role of central sensitisation in osteoarthritis (OA) pain. In this study, we used neuroimaging to compare pain-processing regions of the brain in participants with and without hand OA. We then assessed for volumetric changes in these brain regions following treatment with centrally acting analgesics. METHODS: Participants with hand OA (n = 28) underwent T1-weighted MRI of the brain before and after 12 weeks of treatment with pregabalin, duloxetine or placebo...
June 23, 2018: Rheumatology International
Bob Meek, Johannes C Kelder, Anke M E Claessen, Arend Jan van Houte, Evert-Jan Ter Borg
Primary Sjögren syndrome (pS) is associated with autoantibodies such as rheumatoid factor (RF) and anti-nuclear antibodies such as anti-Ro (SS-A) and/or La (SS-B). Recent developments within autoimmune diagnostics allow quantitation of RF subclasses and anti-Ro epitopes. Will this refinement by autoimmune diagnostics help predicting development of extraglandular manifestations (EGM) in pS patients? A cohort of pS and rheumatoid arthritis (RA) patients with keratoconjunctivitis sicca (n = 35 and 16, resp) was included...
June 23, 2018: Rheumatology International
Lara Valor, Jesús Garrido, Lina Martínez-Estupiñán, Diana Hernández-Flórez, Iustina Janta, Francisco Javier López-Longo, Indalecio Monteagudo, Carlos M González, Esperanza Naredo
To identify features associated with long-term persistent remission in rheumatoid arthritis (RA) patients on tapered biological disease-modifying antirheumatic drugs (bDMARD) (tap-bDMARD) therapy. We carried out a 40-month (m) extension follow-up study of 77 RA patients from a previous 12 m tap-bDMARD study. Disease activity was assessed at baseline and every 3 months. Doppler US investigation of 42 joints for the presence and grade (0-3) of B-mode synovial hypertrophy (SH) and synovial power Doppler signal (i...
June 18, 2018: Rheumatology International
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
Gaurav Seth, K G Chengappa, Durga Prasanna Misra, Ramesh Babu, Pooja Belani, K C Shanoj, Gunjan Kumar, Vir Singh Negi
Retinopathy in the context of systemic lupus erythematosus (SLE) is associated with severe disease and poorer prognosis. We studied retinopathy in our cohort of Indian lupus patients. Four hundred and thirty-seven patients fulfilling the Systemic Lupus International Collaborating Clinics-American College of Rheumatology-2012 criteria, attending the department of Clinical Immunology were enrolled under this cross-sectional study. A comprehensive clinical (including ophthalmological) examination and immunological profile were performed...
June 13, 2018: Rheumatology International
Resat Ozaras, Aslihan Demirel, Suleyman Uraz, Bilgul Mete, Fehmi Tabak
No abstract text is available yet for this article.
June 13, 2018: Rheumatology International
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