journal
MENU ▼
Read by QxMD icon Read
search

Journal of Cellular Biochemistry

journal
https://www.readbyqxmd.com/read/29243846/aqp2-can-modulate-the-pattern-of-ca2-transients-induced-by-store-operated-ca2-entry-under-trpv4-activation
#1
Alejandro Pizzoni, Macarena López González, Gisela Di Giusto, Valeria Rivarola, Claudia Capurro, Paula Ford
There is increasing evidence indicating that aquaporins (AQPs) exert an influence in cell signaling by the interplay with the TRPV4 Ca2+ channel. Ca2+ release from intracellular stores and plasma membrane hyperpolarization due to opening of Ca2+ -activated potassium channels (KCa) are events that have been proposed to take place downstream of TRPV4 activation. A major mechanism for Ca2+ entry, activated after depletion of intracellular Ca2+ stores and driven by electrochemical forces, is the store-operated Ca2+ entry (SOCE)...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243845/fc%C3%AE%C2%B5r1%C3%AE-gene-polymorphism-shows-association-with-high-ige-and-anti-fc%C3%AE%C2%B5r1%C3%AE-in-chronic-rhinosinusitis-with-nasal-polyposis
#2
Sajad Ahmad Dar, Gargi Rai, Mohammad Ahmed Ansari, Naseem Akhter, Neelima Gupta, Sonal Sharma, Shafiul Haque, Vishnampettai Ganapathysubramanian Ramachandran, Mohd Wahid, M Rudramurthy Shivprakash, Arunaloke Chakrabarti, Shukla Das
Despite large number of investigations, the etiology of chronic rhinosinusitis (CRS) remains unclear. Several factors are likely involved in its onset. The genetic susceptibility of IgE-responsiveness likely caused by polymorphism(s) in high affinity receptor for IgE (FcεR1α) gene can help in understanding the pathophysiology of CRS with nasal polyposis (CRSwNP). A population-based case-control association analysis was conducted to assess the risk of CRSwNP conferred by single nucleotide polymorphisms (SNPs) in FcεR1α gene in a North Indian cohort...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243844/in-vitro-improvement-of-quail-primordial-germ-cell-expansion-through-activation-of-tgf-beta-signaling-pathway
#3
Saeed Yakhkeshi, Shaban Rahimi, Mohsen Sharafi, Seyedeh-Nafiseh Hassani, Sara Taleahmad, Abdolhossein Shahverdi, Hossein Baharvand
Avian primordial germ cells (PGCs) have valuable potentials to cell-based approaches for transgenic bird production. In this regard, improvement of avian PGC expansion in vitro is necessary. Among experimental avian species, quail is a good model for transgenic technology, especially due to its short generation time. In the present study, we have examined the proliferative effects of transforming growth factor β (TGF-β) on the quail PGCs. After isolation of quail PGCs from blood [Hamburger-Hamilton (HH stages 13-15)] and gonads (HH stages 28-30), these cells were cultured on quail embryonic fibroblasts (QEF)...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243843/signaling-cascades-in-thyroid-cancer-increasing-the-armory-of-archers-to-hit-bullseye
#4
Faiza Abdul Rashid, Qaisar Mansoor, Hafsa Aziz, Sobia Tabassum, Waleed O Arfat, George E Naoum, Muhammad Ismail, Ammad Ahmad Farooqi
Thyroid cancer is a multifaceted and therapeutically challenging disease and rapidly accumulating experimentally verified findings have considerably improve our understanding of the molecular mechanisms which underlie its development. Substantial fraction of information has been added into existing landscape of molecular oncology and we have started to develop a sharper understanding of the underlying mechanisms of thyroid cancer. Wealth of information demystified different intracellular signaling cascades which are frequently deregulated in thyroid cancer...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243842/exosomes-secreted-by-hypoxic-cardiosphere-derived-cells-enhance-tube-formation-and-increase-pro-angiogenic-mirna
#5
Helia Namazi, Elham Mohit, Iman Namazi, Sarah Rajabi, Azam Samadian, Ensiyeh Hajizadeh-Saffar, Nasser Aghdami, Hossein Baharvand
Exosomes are required for the regenerative effects of human cardiosphere-derived cells (CDCs). Studies show that they mimic the cardioprotective benefits of CDCs in rodents and porcine myocardial infarction (MI) models. Hypoxic preconditioning of stem cells increases the cardioprotective effects of exosomes in MI models by enhancing angiogenesis. Several exosomal microRNAs (miRNAs) up-regulate in response to hypoxia and play a role in cardioprotective and pro-angiogenic effects. In this study, we have demonstrated that human CDCs secreted exosomes under hypoxic conditions (1% O2 for 2 days) enhanced tube formation by human umbilical vein endothelial cells (HUVECs) at a concentration of 25 μg/ml...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243841/encapsulation-challenges-the-substantial-issue-in-solid-lipid-nanoparticles-characterization
#6
Sara Daneshmand, Shiva Golmohammadzadeh, Mahmoud Reza Jaafari, Jebrail Movaffagh, Mehdi Rezaee, Amirhossein Sahebkar, Bizhan Malaekeh-Nikouei
Solid lipid nanoparticles (SLNs), as alternative colloidal carriers, have been used for the sustained release of lipophilic drugs with poor water solubility. One of the most important parameters in the characterization of SLNs is entrapment efficiency (EE). Despite the importance of this factor in estimating the drug loading capacity, EE does not always represent the exact percentage of the entrapped drug. Several variables such as the stirring speed and duration and, concentration of surfactant, emulsifier and drug play important roles in determining the final EE...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243835/diallyl-trisulfide-inhibits-breast-cancer-stem-cells-via-suppression-of-wnt-%C3%AE-catenin-pathway
#7
Xiaoting Li, Yu Meng, Chunfeng Xie, Jianyun Zhu, Xiaoqian Wang, Yuan Li, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Min Li
Cancer stem cells (CSCs) play a central role in the development of breast cancer. The canonical Wnt/β-catenin signal pathway is critical for maintaining CSCs characteristics. Diallyl trisulfide (DATS), a natural organosulfur compound from the garlic, exhibits effective antitumor properties. However, the role of DATS in regulating breast CSCs activity and the underlying molecular mechanisms remain obscure. In the present study, we reported that DATS efficiently inhibited the viability of breast CSCs as evidenced by reducing turmorspheres formation, decreasing the expression of breast CSCs markers (CD44, ALDH1A1, Nanog and Oct4), as well as inhibiting proliferation and inducing apoptosis...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240267/acute-oral-dose-of-sodium-nitrite-causes-redox-imbalance-and-dna-damage-in-rat-kidney
#8
Fariheen Aisha Ansari, Shaikh Nisar Ali, Aijaz Ahmed Khan, Riaz Mahmood
Sodium nitrite (NaNO2) is widely used as a food additive and preservative in fish and meat products. We have evaluated the effect of a single acute oral dose of NaNO2 on oxidative stress parameters, antioxidant capacity and DNA in rat kidney. Male Wistar rats were divided into four groups and given single oral dose of NaNO2 at 20, 40, 60 and 75 mg/kg body weight; untreated rats served as the control group. All animals in NaNO2 -treated groups showed marked alterations in various parameters of oxidative stress as compared to the control group...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240252/ganoderma-microsporum-immunomodulatory-protein-induces-apoptosis-and-potentiates-mitomycin-c-induced-apoptosis-in-urinary-bladder-urothelial-carcinoma-cells
#9
Sheng-Yuan Huang, Chih-Cheng Chien, Ruey-Shyang Hseu, Victoria Ying Jen Huang, Shang Ying Chiang, Chi-Jung Huang, Shao-Kuan Chen, Ru-Yin Tsai, Hsi-Ting Lin, Yu-Che Cheng
Current chemotherapy and immunotherapy treatments followed by transurethral resection for urinary bladder urothelial carcinoma (UC) usually suffers from poor prognosis and high recurrence rate. Design and modification of current formulation with the novel adjuvants is needed. A recombinant protein derived from Ganoderma microsporum named as Ganoderma microsporum immunomodulatory protein (GMIP) were used to treat UC cells. We found GMIP elicits a dose-dependent and time-dependent anti-UC cell proliferation effect, with a half-maximal inhibition concentration (IC50 ) comparable to mitomycin C (MMC), a commonly used chemotherapy agent...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240250/microrna-139-5p-inhibits-epithelial-mesenchymal-transition-and-fibrosis-in-post-menopausal-women-with-interstitial-cystitis-by-targeting-lpar4-via-the-pi3k-akt-signaling-pathway
#10
Chen Jiang, Zhen Tong, Wei-Lin Fang, Qi-Bo Fu, Yin-Jun Gu, Ting-Ting Lv, Dong-Ming Liu, Wei Xue, Jian-Wei Lv
The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. Bladder tissues of IC and normal bladder tissues were collected. The pathology of bladder tissues was observed by HE, Masson and Picrosirius red staining. LPAR4 positive expression rate were determined by IHC. ELISA was performed to detect the levels of IL-6, IL-8, IL-10 and TNF-α. Rat IC models were randomized into seven different groups...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240249/exosomal-mir-6803-5p-as-potential-diagnostic-and-prognostic-marker-in-colorectal-cancer
#11
Shushan Yan, Ye Jiang, Caihong Liang, Chengwen Jin, Quanhong Duan, Donghua Xu, Lu Yang, Xiaoyu Zhang, Bin Ren, Peng Jin
Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were determined by microarray analysis and verified by quantitative real-time PCR (qRT-PCR). Outcomes of overall survival (OS) and disease-free survival (DFS) of CRC patients were estimated by Kaplan-Meier analysis...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240248/sperm-binding-to-porcine-oviductal-cells-is-mediated-by-srcr-domains-contained-in-dmbt1
#12
María Lorena Roldán, Juan Manuel Teijeiro, Jimena Ruiz Álvarez, Patricia Estela Marini
The oviduct is an organ in which a subpopulation of sperm is stored in a reservoir, preserving its fertilizing potential. In porcine, two oviductal proteins have been identified in relation to sperm binding, Annexin A2 and Deleted in Malignant Brain Tumour 1 (DMBT1). DMBT1 is a multifunctional, multidomain glycoprotein and the characteristics of all of its domains, as well as its carbohydrates, make them candidates for sperm binding. In this work, we challenge sperm for binding to pig oviductal cells on primary culture, after treatment with antibodies specific for the different domains present in DMBT1...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240246/hyperthermia-enhances-radiosensitivity-of-colorectal-cancer-cells-through-ros-inducing-autophagic-cell-death
#13
Ming-Chen Ba, Hui Long, Shuai Wang, Yin-Bing Wu, Bo-Huo Zhang, Zhao-Fei Yan, Fei-Hong Yu, Shu-Zhong Cui
BACKGROUND: Hyperthermia (HT) enhances the anti-cancer effects of radiotherapy (RT), but the precise biochemical mechanisms involved are unclear. This study was aim to investigate if mild HT sensitizes colorectal cancer cells to RT through reactive oxygen species (ROS)-inducing autophagic cell death in a mice model of HCT116 human colorectal cancer. METHODS: HCT116 mice model were randomly divided into five groups: mock group, hyperthermia group (HT), radiotherapy group (RT), HT + RT group, and HT + RT +N-acetyl L-cysteine (NAC) group (HT + CT + NAC)...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240240/ultrasound-triggered-effects-of-the-microbubbles-coupled-to-gdnf-and-nurr1-loaded-pegylated-liposomes-in-a-rat-model-of-parkinson-s-disease
#14
Peijian Yue, Lin Gao, Xuejing Wang, Xuebing Ding, Junfang Teng
The purpose of this study was to investigate ultrasound-triggered effects of the glial cell line-derived neurotrophic factor (GDNF) + nuclear receptor-related factor 1 (Nurr1)-polyethylene glycol (PEG)ylated liposomes-coupled microbubbles (PLs-GDNF+Nurr1-MBs) on behavioral impairment and neuron loss in a rat model of Parkinson's disease (PD). The unloaded PEGylated liposomes-coupled microbubbles (PLs-MBs) were characterized for zeta potential, particle size, and concentration. 6-hydroxydopamine (6-OHDA) was used to establish the PD rat model...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29240236/evaluation-of-osteoblast-differentiation-and-function-when-cultured-on-mesoporous-bioactive-glass-adsorbed-with-testosterone
#15
Kai Gao, Xiaoyan Wang, Qianqian Liu, Wei Chen, Gan Wang, Dongyi Zhang, Long Liu
Mesoporous bioactive glass (MBG), a kind of porous materials with great osteoconductive and osteoinductive ability, shows promising application in bone tissue engineering due to its high specific surface area, orderly channel structure and large pore volume. Here we reported that the proliferation, differentiation and mineralization were promoted in MC3T3-E1 cells cultured on MBG which adsorbed with testosterone (MBG/T). We found that transcriptional activity of Runx2 which is a critical transcription factor is increased in MC3T3-E1 cells cultured on MBG/T...
December 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239022/fndc5-knockdown-induced-suppression-of-mitochondrial-integrity-and-significantly-decreased-cardiac-differentiation-of-mouse-embryonic-stem-cells
#16
Shima Nazem, Farzaneh Rabiee, Kmaran Ghaedi, Sadegh Babashah, Majid Sadeghizadeh, Mohammad Hossein Nasr-Esfahani
Fibronectin type III domain-containing 5 protein (Fndc5) is a glycosylated protein with elevated expression in high energy demanded tissues as heart, brain and muscle. It has been shown that upregulation of Fndc5 is regulated by peroxisome proliferator-activated receptor-γ coactivator-1 alpha (PGC-1α), which is known as a master regulator of mitochondrial function and biogenesis. Also, our group indicated that Fndc5 expression increases gradually during cardiac differentiation of mouse embryonic stem cells (mESCs)...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29239017/five-key-lncrnas-considered-as-prognostic-targets-for-predicting-pancreatic-ductal-adenocarcinoma
#17
Jukun Song, Qiuyan Yan, Haodeng Zhang, Xinhai Yin, Chen Zhu, Ke Zhao, Jianguo Zhu
To improve PDCA prognosis, a screening biomarker for early diagnosis of pancreatic cancer is in urgent need. Long non-coding RNA (lncRNA) expression profiles as potential cancer prognostic biomarkers play critical roles in development of tumorigenesis and metastasis of cancer. However, lncRNA signatures in predicting the survival of a patient with PDAC remain unknown. In the current study, we try to identify potential lncRNA biomarkers and their prognostic values in PDAC. LncRNAs expression profiles and corresponding clinical information for 182 cases with PDAC were acquired from The Cancer Genome Atlas (TCGA)...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236333/effect-and-mechanism-of-lncrna-hotair-on-occurrence-and-development-of-gastric-cancer
#18
Xuan Feng, Suiping Huang
OBJECTIVE: In this study, we aimed at looking for the lncRNA abnormally expressed in gastric cancer (GC) tissues, and analyzing the association of its expression level with the clinicopathological feature and patient prognosis. The biological function of this lncRNA in occurrence and development of GC was studied in vivo and in vitro. The underlying molecular mechanism was further discussed. METHODS: We investigated the lncRNA expression level in GC tissues and normal gastric mucosa tissues by lncRNA chips analysis...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236331/reduction-of-histone-marks-h3k9me3-and-h3k27me3-by-epidrug-induces-neuroendocrine-differentiation-in-prostate-cancer
#19
Eunsohl Lee, Jingcheng Wang, Younghun Jung, Frank C Cackowski, Russell S Taichman
Neuroendocrine prostate cancer (NE PCa) is an aggressive malignancy, often presenting with advanced metastasis. We previously reported that reduction of histone marks regulated by DNMT1 following epidrug (5-Azacitidine, 5-Aza) treatment controls induction of epithelial to mesenchymal (EMT) and a cancer stem cell (CSC) phenotype, which facilitates tumorigenesis in PCa cells. Here, we use the epidrug 5-Aza as a model for how histone marks may regulate the reprogramming of prostate adenocarcinoma into NE phenotypic cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236328/mirnalet-7a-mediates-prostate-cancer-pc-3-cell-invasion-migration-by-inducing-epithelial-mesenchymal-transition-through-ccr7-mapk-pathway
#20
Tang Guanlin, Du Ruoyang, Tang Zhaobing, Kuang Youlin
Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let-7a expression decreased in prostate cancer, while the expression of C-C chemokine receptor type 7 (CCR7) increased. In this study, we investigated whether CCR7 overexpression was associated with a decrease in the expression of miRNA let-7a in invasion and metastasis of prostate cancer cell. Methods Synthetic let-7a mimics and let-7a inhibitors were transfected into prostate cancer PC-3 cells repectively...
December 13, 2017: Journal of Cellular Biochemistry
journal
journal
28315
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"