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Journal of Cellular Biochemistry

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https://www.readbyqxmd.com/read/30335904/influenza-a-virus-neuraminidase-protein-interacts-with-hsp90-to-stabilize-itself-and-enhance-cell-survival
#1
Purnima Kumar, Pratibha Gaur, Rashmi Kumari, Sunil K Lal
Neuraminidase protein (NA) of influenza A virus (IAV) is popularly known for its sialidase function to assist in the release of progeny virus. However, involvement of NA in other stages of the IAV life cycle also indicates its multifunctional nature and necessity to interact with other host proteins. Here, we report a host protein-heat shock protein 90 (Hsp90), as a novel interacting partner of IAV NA. A classical yeast two-hybrid screen was conducted to identify a new host interacting partner for NA and the interaction was further validated by coimmunoprecipitation from cells, transiently expressing both proteins and also from IAV-infected cells...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335903/microrna-206-is-required-for-osteoarthritis-development-through-its-effect-on-apoptosis-and-autophagy-of-articular-chondrocytes-via-modulating-the-phosphoinositide-3-kinase-protein-kinase-b-mtor-pathway-by-targeting-insulin-like-growth-factor-1
#2
Qian Yu, Bei Zhao, Qi He, Yuan Zhang, Xian-Bo Peng
microRNA (miR) has been shown to be involved in the treatment of diseases such as osteoarthritis (OA). This study aims to investigate the role of miR-206 in regulating insulin-like growth factor-1 (IGF-1) in chondrocyte autophagy and apoptosis in an OA rat model via the phosphoinositide 3-kinase (P13K)/protein kinase B (AKT)-mechanistic target of rapamycin (mTOR) signaling pathway. Wistar rats were used to establish the OA rat model, followed by the observation of histopathological changes, Mankin score, and the detection of IGF-1-positive expression and tissue apoptosis...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335902/microrna-34a-promotes-cmecs-apoptosis-and-upregulate-inflammatory-cytokines-thus-worsening-cmecs-damage-and-inhibiting-angiogenesis-by-negatively-targeting-the-notch-signaling-pathway
#3
Jia Li, Jin Gong, Xiaobing Li, Li Shen, Yewei Xie, Rufang Zhang
OBJECTIVE: Recently, microRNA-34a (miR-34a) has been reported to lead to secretion of proinflammatory cytokine in endothelial cells, whereas whether miR-34a plays a protective role in damaged cardiac microvascular endothelial cells (CMECs) remains to be determined. Herein, the purpose of this study is to explore the effect of miR-34a in mediating Notch signaling pathway in apoptosis and angiogenesis of damaged CMECs. METHODS: The primary mice CMECs were isolated, cultivated, and identified before establishment of damaged CMEC model by incubation with homocysteine (HCY) for 24 hours...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335901/microrna-212-suppresses-nonsmall-lung-cancer-invasion-and-migration-by-regulating-ubiquitin-specific-protease-9
#4
Wei Chen, Yuye Huang, Shufen Zhang, Xiaoxiao Zheng, Shangzhi Xie, Jiayan Mao, Ying Cai, Xuemei Lu, Liqiang Hu, Jian Shen, Ying Dong, Kequn Chai
MicroRNAs (miRNAs) play crucial roles in various biological processes, including migration, proliferation, differentiation, cell cycling, and apoptosis. Epithelial-mesenchymal transition (EMT) has been shown to be related to the capability of migration and invasion in many tumor cells. In this study, we used wound-healing assay and transwell invasion to analysis the capability of migration and invasion in non-small-cell lung carcinoma (NSCLC), respectively. The expression of ubiquitin-specific protease-9-X-linked (USP9X) and miR-212 messenger RNA (mRNA) was determined by quantitative real-time polymerase chain reaction and Western blot analysis was used to determine the E-cadherin and vimentin expression...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335900/low-expression-of-ncoa5-predicts-poor-prognosis-in-human-cervical-cancer-and-promotes-proliferation-migration-and-invasion-of-cervical-cancer-cell-lines-by-regulating-notch3-signaling-pathway
#5
Ying Liang, Tianli Zhang, Mengdie Shi, Shuo Zhang, Yaxing Guo, Jiwei Gao, Xingsheng Yang
Nuclear receptor coactivator 5 (NCOA5) specifically enhances estrogen receptor α-modulated transcriptional activity. As a novel tumor suppressor, depletion of NCOA5 is associated with the development of a variety of tumors, but its function in cervical cancer is currently unclear. In this study, we addressed how expression of NCOA5 changed in the development of human cervical cancer and its association with clinicopathological features, prognosis, and biology characteristics of cervical cancer. Analysis of the microarrays in the Oncomine database indicated that NCOA5 expression was lower in human cervical squamous cell carcinoma tissues than that in normal cervical tissues...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335899/effects-of-inflammatory-cytokines-on-bone-cartilage-repair
#6
Tingshuai Zhang, Yongchang Yao
Many inflammatory factors can affect cell behaviors and work as a form of inter-regulatory networks through the inflammatory pathway. Inflammatory cytokines are critical for triggering bone regeneration after fracture or bone injury. Also, inflammatory cytokines play an important role in cartilage repair. The synergistic or antagonistic effects of both proinflammatory and anti-inflammatory cytokines have a great influence on fracture healing. This review discusses key inflammatory cytokines and signaling pathways involved in bone or cartilage repair...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335898/investigation-of-igf1-igf2bp2-and-igfbp3-variants-with-lymph-node-status-and-esophagogastric-junction-adenocarcinoma-risk
#7
Weifeng Tang, Shuchen Chen, Jun Liu, Chao Liu, Yafeng Wang, Mingqiang Kang
Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism-related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G > T, rs1470579 A > C, IGF1 rs5742612 A > G and IGFBP3 rs3110697 G > A, rs2270628 C > T and rs6953668 G > A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335897/dependence-of-artesunate-on-long-noncoding-rna-rp11-to-inhibit-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma
#8
Wu Jing, Hu Dong, Mu Min, Zhao Runpeng, Xu Xuewei, Cai Ru, Xing Yingru, Ni Shengfa, Tie Baoxian, Yue Jinbo, Han Weidong, Zhang Rongbo
As a first line medicine for malaria treatment, artesunate (ART) also shows antitumor potential. However, little is known about the effect of ART on the cancer cell epithelial-mesenchymal transition (EMT). In this study, we found that ART inhibited cell growth in SK-HEP1 and SM7721 hepatocellular carcinoma cell lines. A microarray was used to identify differentially expressed protein-coding RNAs (pcRNA) and long noncoding RNAs (lncRNA) between SK-HEP1 cells with and without ART treatment. A differentially expressed lncRNA-RP11, the most related to the EMT of liver cancer cells-RP11 was identified by abioinformatics method Overexpressing and silencing assays were used to verify the role of RP11 in cancer cell EMT...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335896/mirna-206-regulates-human-pulmonary-microvascular-endothelial-cell-apoptosis-via-targeting-in-chronic-obstructive-pulmonary-disease
#9
Ying Sun, Na An, Jiansheng Li, Jinchan Xia, Yange Tian, Peng Zhao, Xuefang Liu, Haiying Huang, Jianfeng Gao, Xiaoli Zhang
Chronic obstructive pulmonary disease (COPD) is a leading cause of death due to tis high morbidity and mortality. microRNAs have emerged as new biomarkers for the prognosis and diagnosis of patients with COPD. In this study, we aimed to investigate the expression of microRNA-206 (miR-206) in lung tissues from COPD patients and to explore the regulatory role of miR-206 in the human pulmonary microvascular endothelial cells (HPMECs). Our results showed that cigarette smoke extract (CSE) promoted cell apoptosis, increased caspase-3 activity, and upregulated the expression of miR-206 in HPMECs, which was significantly reversed by the miR-206 knockdown...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335895/mir-148a-regulates-bone-marrow-mesenchymal-stem-cells-mediated-fracture-healing-by-targeting-insulin-like-growth-factor-1
#10
Hongzhi Liu, Hao Su, Xin Wang, Wei Hao
The purpose of this study was to investigate the underlying molecular mechanisms of fracture healing mediated by bone marrow mesenchymal stem cells. Differentially expressed microRNAs in acutely injured subjects and healthy volunteers were screened by microarray analysis. The dual luciferase reporter system was used to verify whether insulin-like growth factor 1 (IGF1) was the direct target gene regulated by miR-148a. The expression level of miR-148a and IGF1 after osteogenic differentiation was detected by quantitative real-time polymerase chain reaction...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335894/microarray-based-identification-of-genes-associated-with-prognosis-and-drug-resistance-in-ovarian-cancer
#11
Fuqiang Yin, Shang Yi, Luwei Wei, Bingbing Zhao, Jinqian Li, Xiangxue Cai, Caihua Dong, Xia Liu
The outcome for patients with ovarian cancer (OC) is poor because of drug resistance. Therefore, identification of factors that affect drug resistance and prognosis in OC is needed. In the present study, we identified 131 genes significantly dysregulated in 90 platinum-resistant OC tissues compared with 197 sensitive tissues, of which 30 were significantly associated with disease-free survival (DFS; n = 16), overall survival (OS; n = 6), or both (n = 8) in 489 OC patients of the The Cancer Genome Atlas cohort...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335892/long-noncoding-rna-hotair-silencing-inhibits-invasion-and-proliferation-of-human-colon-cancer-lovo-cells-via-regulating-igf2bp2
#12
Xue-Liang Wu, Rui-Yun Lu, Li-Kun Wang, Yuan-Yuan Wang, Yong-Jun Dai, Chen-Yu Wang, Yong-Jiang Yang, Fei Guo, Jun Xue, Dong-Dong Yang
Colon cancer is one of the most life-threatening malignancies worldwide. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) is a cancer-associated biomarker involved in the metastasis and prognosis of several cancers. However, whether and how HOTAIR affects colon cancer progression is still unclear. Consequently, we used RNA interference to knock down HOTAIR to explore its effects on human colon cancer cells. The dual luciferase reporter gene assay was initially used for testify the regulating relationship between lncRNA HOTAIR and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335891/evaluation-of-exosomal-mir-9-and-mir-155-targeting-pten-and-dusp14-in-highly-metastatic-breast-cancer-and-their-effect-on-low-metastatic-cells
#13
Vahid Kia, Mahdi Paryan, Yousef Mortazavi, Alireza Biglari, Samira Mohammadi-Yeganeh
Breast cancer is one of the most prevalent cancers in women. Triple-negative breast cancer consists 15% to 20% of breast cancer cases and has a poor prognosis. Cancerous transformation has several causes one of which is dysregulation of microRNAs (miRNAs) expression. Exosomes can transfer miRNAs to neighboring and distant cells. Thus, exosomal miRNAs can transfer cancerous phenotype to distant cells. We used gene expression omnibus (GEO) datasets and miRNA target prediction tools to find overexpressed miRNA in breast cancer cells and their target genes, respectively...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335890/expression-of-osteoprotegerin-and-receptor-activator-for-the-nuclear-factor-%C3%AE%C2%BAb-ligand-in-xacb-lv-bfgf-mscs-transplantation-for-repair-of-rabbit-femoral-head-defect-necrosis
#14
Wuxun Peng, Jian Zhang, Fei Zhang, Yin Zhao, Wentao Dong
The aim of this study is to observe the changes in osteoprotegerin (OPG) and receptor activator for the nuclear factor-κB ligand (RANKL) in a rabbit model, and to explore the therapeutic effect of tissue engineering bone on femoral head necrosis. A total of 60 rabbits were randomly divided into 5 groups. The necrosis model of femoral head defects was created by dexamethasone combined with a horse serum injection. The model of femoral head necrosis was reconstructed by tissue engineering bone. The protein expressions of OPG and RANKL were detected by Western blot analysis...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335889/berberrubine-and-its-analog-hydroxypropyl-berberrubine-regulate-ldlr-and-pcsk9-expression-via-the-erk-signal-pathway-to-exert-cholesterol-lowering-effects-in-human-hepatoma-hepg2-cells
#15
Shijie Cao, Peixiang Xu, Jiankun Yan, Hui Liu, Lu Liu, Lina Cheng, Feng Qiu, Ning Kang
Berberine (BBR), the major isoquinoline alkaloid in Chinese herb Rhizoma coptidis, has significant lipid-lowering effect by upregulating hepatic low-density lipoprotein receptor (LDLR) expression. In a previous study, we have indicated that berberrubine (M3), a major metabolite of BBR in vivo, displays the most potential hypolipidemic effects via upregulating LDLR expression in human hepatoma (HepG2) cells compared with BBR and 3 other metabolites. Accordingly, 9 M3 analogs (A1-A9) were modified at the C9 position...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335888/lncrna-x-inactive-specific-transcript-contributes-to-neuropathic-pain-development-by-sponging-mir-154-5p-via-inducing-toll-like-receptor-5-in-cci-rat-models
#16
Meng Wei, Lin Li, Yang Zhang, Zhi-Jie Zhang, Hai-Lin Liu, Hong-Guang Bao
Noncoding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs, are involved in the development of neuropathic pain. Currently, we investigated that lncRNA X inactive-specific transcript (XIST) and toll-like receptor 5 (TLR5) were greatly upregulated in chronic constriction injury rat models, whereas miR-154-5p (microRNA-154-5p) was significantly downregulated. Bioinformatics analysis was used to predict miR-154-5p as a target gene of XIST, and dual-luciferase reporter tests proved the correlation between them...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335887/pml-rara-blocks-the-differentiation-and-promotes-the-proliferation-of-acute-promyelocytic-leukemia-through-activating-myb-expression-by-transcriptional-and-epigenetic-regulation-mechanisms
#17
Genjie Wang, Ying Tian, Qingzhu Hu, Xichun Xiao, Shuxia Chen
The promyelocytic leukemia (PML)/retinoic acid receptor-alpha (RARα) onco-fusion protein that is generated from t(15;17) chromosome translocation is crucial for the leukemogenesis of acute promyelocytic leukemia (APL) and is well documented as a transcriptional repressor. To understand the relationship between PML/RARα and the oncogene in the development of APL, we investigate the regulation mechanism of PML/RARα to MYB proto-oncogene and the role of this regulation on the proliferation and differentiation of APL cells...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335886/ebf1-gene-promotes-the-proliferation-and-inhibits-the-apoptosis-of-bone-marrow-cd34-cells-in-patients-with-myelodysplastic-syndrome-through-negative-regulation-of-mitogen-activated-protein-kinase-axis
#18
Shuang Hou, Jie Hao, Yan-Yu Wang, Bing-Bing Zhao, Gong-Wei Xiao, Yan-Qing Li, Xi Liu, Zhi-Lan Zou, Ye Yao, Hong Xiong
The transcription factor, early B cell factor 1 (EBF1), plays a vital role in the lineage specification involving early B cell development and the onset of myelodysplastic syndrome (MDS). Therefore, to investigate whether or not EBF1 affects MDS as well as the transcription factor's underlying mechanism, we used CD34+ hematopoietic stem cells in bone marrow from patients with MDS. The extracted cells were then transfected with a series of EBF1, short hairpin RNA against EBF1 (shEBF1), and SB203580 (a specific mitogen-activated protein kinase [MAPK] axis inhibitor)...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335885/molecular-and-disease-association-of-gestational-diabetes-mellitus-affected-mother-and-placental-datasets-reveal-a-strong-link-between-insulin-growth-factor-igf-genes-in-amino-acid-transport-pathway-a-network-biology-approach
#19
Madhusmita Rout, Sajitha Lulu S
Discerning the relationship between molecules involved in diseases based on their underlying biological mechanisms is one of the greatest challenges in therapeutic development today. Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, which adversely affects both mothers and offspring during and after pregnancy. We have constructed two datasets of (GDM associated genes from affected mother and placenta to systematically analyze and evaluate their interactions like gene-gene, gene-protein, gene-microRNA (miRNA), gene-transcription factors, and gene-associated diseases to enhance our current knowledge, which may lead to further advancements in disease diagnosis, prognosis, and treatment...
October 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30335884/reelin-regulates-male-mouse-reproductive-capacity-via-the-sertoli-cells
#20
Mengru Zhuang, Bo Li, Yangxue Huang, Qijing Lei, Ruichuan Yan, Na Li, Kuldip Sidhu, Xiang Cheng, Xinrong Yan, Yiliang Miao, Shanting Zhao, Jinlian Hua
Reelin plays important roles in brain development. Reeler mutant mice that lack the protein reelin (RELN) suffer from cell type- and region-dependent changes in their neocortical layers, and adult reeler mutant mice have dilated seminiferous tubules. Meanwhile, the mechanism by which Reelin regulates the spermatogenic cell development in mice and their reproductive abilities remains unclear. In the present study, we used reeler mutant mice to investigate the effects of Reelin on reproduction in mice. The results indicated variations in sex hormone expression among the reeler mice, indicating that they produce few offspring and their spermatogenic cells are irregularly developed...
October 18, 2018: Journal of Cellular Biochemistry
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