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Journal of Cellular Biochemistry

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https://www.readbyqxmd.com/read/29667771/long-non-coding-rna-snhg14-contributes-to-gastric-cancer-development-through-targeting-mir-145-sox9-axis
#1
Zhao Liu, Yan Yan, Sizhe Cao, Yi Chen
This study aimed to elucidate the roles of long non-coding RNA SNHG14 in gastric cancer development. LncRNA SNHG14 was markedly up-regulated in gastric cancer tissues and cells. Knockdown of SNHG14 significantly inhibited SGC-7901 cell viability, migration, invasion, and promoted cell apoptosis. In addition, miR-145 was negatively regulated by SNHG14 and the effects of SNHG14 knockdown on cell viability, apoptosis, migration, invasion, and the expression of apoptosis-related proteins and EMT-markers were reversed by inhibition of miR-145 at the same time...
April 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665148/matrix-metalloproteinases-2-mmp-2-and-matrix-metalloproteinases-9-mmp-9-are-differentially-expressed-in-different-regions-of-normal-and-preeclampsia-placentae
#2
Akriti S Sahay, Anjali T Jadhav, Deepali P Sundrani, Girija N Wagh, Savita S Mehendale, Sadhana R Joshi
Matrix metalloproteinases (MMPs) are involved in the extracellular matrix (ECM) remodeling during human placentation and parturition and have been shown to be associated with oxidative stress. Placental regional changes in oxygen availability and oxidative stress indices may influence regional differences in expression of MMPs. This study examines the protein and mRNA levels of MMP-2 and MMP-9 in different regions of the placenta in normotensive control (NC) women and women with preeclampsia (PE). Fifty-two NC women and 43 women with PE (18 delivered at term [T-PE] and 25 delivered preterm [PT-PE]) were recruited...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665144/disulfiram-copper-targets-stem-cell-like-aldh-population-of-multiple-myeloma-by-inhibition-of-aldh1a1-and-hedgehog-pathway
#3
Na Jin, Xiaojian Zhu, Fanjun Cheng, Liling Zhang
Multiple myeloma stem cells (MMSCs) have been considered as the major cause resulting in relapse. Eradicating MMSCs may be an effective strategy to improve the outcome of multiple myeloma (MM). Increased activity of aldehyde dehydrogenase (ALDH) has been found in MMSCs, but whether inhibiting ALDH activity can eliminate MMSCs remains unknown. Disulfiram (DS) has been reported as an inhibitor of ALDH, and increasing studies showed it has anti-cancer effects in a copper (Cu)-dependent manner. In this study, we isolated ALDH+ cells of MM by Aldefluor assay and demonstrated they possessed tumorigenesis capacities in vitro and in vivo...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665121/homoharringtonine-could-induce-quick-protein-synthesis-of-psmd11-through-activating-mek1-erk1-2-signaling-pathway-in-pancreatic-cancer-cells
#4
Lele Wang, Linlin Zhao, Guo Wei, Dieter Saur, Barbara Seidler, Junyan Wang, Chuanxin Wang, Tonggang Qi
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating disease with the 5-year survival rate less than 6%. In this study, we investigated if inhibiting protein synthesis directly with homoharringtonine (HHT) could induce acute apoptosis in pancreatic cancer cells through quick depletion of multiple short-lived critical members of the central proteome, example, PSMD11(26S proteasome non-ATPase regulatory subunit 11). It was shown that although HHT could inhibit proliferation and growth of MiaPaCa-2 and PANC-1 cells in a time- and dose-dependent manner, only part of pancreatic cancer cells could be induced to die through acute apoptosis...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665059/tannic-acid-modulates-fibroblast-proliferation-and-differentiation-in-response-to-pro-fibrotic-stimuli
#5
Dhamotharan Pattarayan, Ayyanar Sivanantham, Ramalingam Bethunaickan, Rajaguru Palanichamy, Subbiah Rajasekaran
In response to tissue injury, fibroblasts migrate into the wound, where they undergo proliferation and differentiation. The persistence of these differentiated fibroblasts (myofibroblasts) is associated with excessive scarring in various organs. We aimed to investigate the effects of Tannic acid (TA) on fibroblast proliferation and differentiation, and found that TA inhibited fibroblast differentiation as assessed by reduced expression of α-smooth muscle actin, N-cadherin, and type-1-collagen. TA also prevented the TGF-β1-induced alteration in the expression of two classes of genes involved in the remodeling of extracellular matrix (ECM) proteins, namely matrix metalloproteinases (Mmp-2 and -9) and tissue inhibitors of metalloproteinases (Timp-1 and -3)...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665055/s6k1-controls-epigenetic-plasticity-for-the-expression-of-pancreatic-%C3%AE-%C3%AE-cell-marker-genes
#6
Sang Ah Yi, Jieun Lee, Jong Woo Park, Jihoon Han, Min Gyu Lee, Ki Hong Nam, Jee Hun Park, Hwamok Oh, Sung Jin Ahn, Saetbyul Kim, So Hee Kwon, Dong-Gyu Jo, Jeung-Whan Han
The failure of insulin production by pancreatic β cells is a common hallmark of type 1 diabetes mellitus (T1DM). Because administration of exogenous insulin is associated with diabetes-derived complications, endogenous α to β cell transition can be an attractive alternative. Although decreased β cell size and hypoinsulinaemia have been observed in S6K1-deficient mice, the molecular mechanism underlying the involvement of S6K1 in the transcriptional regulation of insulin remains elusive. Here, we show that the hypoinsulinaemic phenotype of S6K1-deficient mice stems from the dysregulated transcription of a set of genes required for insulin and glucagon production...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665052/the-role-of-high-mobility-group-protein-box-1-in-lung-cancer
#7
Xiao-Jin Wu, Yuan-Yuan Chen, Chan-Chan Gong, Dong-Sheng Pei
High-mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin-binding factor, HMGB1 binds to DNA and plays an important role in stabilizing nucleosome formation, facilitating gene transcription, DNA repairing, inflammation, cell differentiation, and regulating the activity of steroid hormone receptors. Currently, HMGB1 is discovered to be related to development, progression, and targeted therapy of lung cancer, which makes it an attractive biomarker, and therapeutic target...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665051/hyperbaric-oxygen-treatment-sensitizes-gastric-cancer-cells-to-melatonin-induced-apoptosis-through-multiple-pathways
#8
Xiang Wei, Yinliang Qi, Ning Jia, Qing Zhou, Sumei Zhang, Yuan Wang
Although extensive efforts have been made in recent decades to treat advanced gastric cancer with comprehensive therapy based on chemotherapy, effective anti-gastric cancer therapeutics are still lacking in the clinics. Therefore, potent novel anti-gastric cancer ways are greatly needed. Here, we explored hyperbaric oxygen treatment as a novel and effective adjuvant treatment method which has anti-gastric cancer effects when used together with melatonin. When performed together with MLT, HBO effectively inhibited tumorigenicity of gastric cancer through selectively inducing a robust tumor suppressive apoptosis response...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665050/silence-of-hdac6-suppressed-esophageal-squamous-cell-carcinoma-proliferation-and-migration-by-disrupting-chaperone-function-of-hsp90
#9
Hua Tao, Yuan-Yuan Chen, Zong-Wen Sun, Hua-Lin Chen, Ming Chen
Esophageal carcinoma is aggressive in nature and its prognosis is largely dependent on the degree of invasion. Histone deacetylase 6 (HDAC6), as the most unique member of HDACs family, has the positive activity to promote initiation and progression of various cancers via targeting multiple non-histone proteins in cytoplasm. In this study, we found that HDAC6 was over-expressed in three esophageal cancer cell lines (KYSE140, KYSE170, KYSE180) when compared to non-carcinoma esophageal epithelial cell HEEC-1. Then two HDAC6 specific siRNAs and HDAC6 inhibitor tubastatin A greatly suppressed KYSE140 and KYSE180 cells proliferation and migration, and the inhibition of cell motility was accompanied by elevated acetylation of α-tubulin, a target of HDAC6...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29665049/protective-effects-of-progranulin-against-focal-cerebral-ischemia-reperfusion-injury-in-rats-by-suppressing-endoplasmic-reticulum-stress-and-nf-%C3%AE%C2%BAb-activation-in-reactive-astrocytes
#10
Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang Wu
The aim of this study is to explore the effect progranulin (PGRN) has on endoplasmic reticulum (ER) stress and the NF-κB activation in reactive astrocytes found in rat models with focal cerebral ischemia-reperfusion (I/R) injury. Sprague-Dawley (SD) rats were grouped into the sham, I/R, PGRN-high dose, PGRN-low dose, and negative control (NC) groups. TTC staining was applied in order to detect the cerebral infarction volume, a TUNEL assay to detect the apoptosis rate of neurons, an ELISA to measure MDA, SOD, iNOS, LDH, TNF-α, IL-1β, IL-6, and IL-10 levels, and both RT-qPCR and western blotting methods in order to detect PGRN, GFAP, GRP78, CHOP, and NF-κB p65 expressions...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663535/hypothyroidism-and-hyperthyroidism-change-ectoenzyme-activity-in-rat-platelets
#11
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Caroline C Martins, Daniela Zanini, Karine P Reichert, Gustavo R Thomé, Taís V Palma, Pauline da Costa, Vera M Morsch, Maria R C Schetinger
The purinergic system has an important role in the regulation of vascular functions. The interference of thyroid hormones in this system and in cardiovascular events has been studied in recent years. However, the mechanisms involved in vascular, purinergic, and oxidative changes in thyroid disorders are not completely understood. Therefore, the present study aimed to assess purinergic enzyme activity in platelets from rats with hypothyroidism and hyperthyroidism induced, respectively, by continuous exposure to methimazole (MMI) at 20 mg/100 mL or L-thyroxine at 1...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663531/identification-of-variants-in-the-mitochondrial-lysine-trna-mt-tk-gene-in-myoclonic-epilepsy-pathogenicity-evaluation-and-structural-characterization-by-in-silico-approach
#12
Muhammad S Nadeem, Habib Ahmad, Kaleemuddin Mohammed, Khushi Muhammad, Inam Ullah, Othman A S Baothman, Nasir Ali, Firoz Anwar, Mazin A Zamzami, Abdul Rauf Shakoori
Variations in mitochondrial genes have an established link with myoclonic epilepsy. In the present study we evaluated the nucleotide sequence of MT-TK gene of 52 individuals from 12 unrelated families and reported three variations in 2 of the 13 epileptic patients. The DNA sequences coding for MT-TK gene were sequenced and mutations were detected in all participants. The mutations were further analyzed by the in silico analysis and their structural and pathogenic effects were determined. All the investigated patients had symptoms of myoclonus, 61...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663529/a-group-of-tissue-specific-micrornas-contribute-to-the-silencing-of-cux1-in-different-cell-lineages-during-development
#13
Hui Xu, Jie-Hua He, Shi-Jun Xu, Shu-Juan Xie, Li-Ming Ma, Yin Zhang, Hui Zhou, Liang-Hu Qu
Cut-like homeobox 1 (CUX1) is a highly conserved homeoprotein that functions as a transcriptional repressor of genes specifying terminal differentiation. We previously showed that liver-specific microRNA-122 (miR-122) regulates the timing of liver development by silencing CUX1 post-transcriptionally. Since the CUX1 protein is expressed in a subset of embryonic tissues, we hypothesized that it is regulated by specific microRNAs (miRNAs) in each cell type during development. Using a large-scale screening method, we identified ten tissue-specific miRNAs from different cell lineages that directly targeted CUX1...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663503/mir-135a-represses-oxidative-stress-and-vascular-inflammatory-events-via-targeting-toll-like-receptor-4-in-atherogenesis
#14
Xian-Jin Du, Jing-Min Lu
Plenty of microRNAs have been identified as critical mediators in atherosclerosis progression, which is still a great threat to human health. Oxidative stress and inflammation have been implicated to contribute a lot to atherosclerosis development. MiR-135a is abnormally expressed in various cancer types, however its function in atherosclerosis is largely unexplored. Ox-LDL is commonly recognized as a crucial atherosclerosis regulator. In our current study, we observed ox-LDL was able to induce RAW264.7 cell apoptosis and meanwhile miR-135a was restrained by ox-LDL both dose-dependently and time- dependently...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663501/the-effect-of-plant-lectins-on-the-survival-and-malignant-behaviors-of-thyroid-cancer-cells
#15
Engin Kaptan, Serap Sancar-Bas, Aylin Sancakli, Suna Bektas, Sehnaz Bolkent
Altered or aberrant glycosylation is a common phenomenon in cancer cells and it originates from changes in the expression of the enzymes, glycosyltransferase, and glycosidase which up-regulate in response to some oncogenes in the glycan synthesis pathway. In this present study, it has been aimed to determine the alteration of sialic acid and fucose expressions in the cell surface of human thyroid carcinoma cells and investigate the changes in tumorigenic and malignant characters after treating them with specific plant lectins...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663500/knockdown-of-lncrna-uca1-suppresses-chemoresistance-of-pediatric-aml-by-inhibiting-glycolysis-through-the-microrna-125a-hexokinase-2-pathway
#16
Yuan Zhang, Yufeng Liu, Xueju Xu
Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression in AML patients after adriamycin (ADR)-based chemotherapy and ADR-resistant AML cells was examined by qRT-PCR. The effects of UCA1 on the cytotoxicity of ADR and glycolysis were evaluated by MTT assay and measuring the glucose consumption and lactate production in HL60 and HL60/ADR cells, repectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663499/resveratrol-inhibits-the-proliferation-and-induces-the-apoptosis-in-ovarian-cancer-cells-via-inhibiting-glycolysis-and-targeting-ampk-mtor-signaling-pathway
#17
Yu Liu, Lin Tong, Yan Luo, Xin Li, Gaowen Chen, Yifeng Wang
Aerobic glycolysis is an important metabolic rewiring in cancer cells to promote glucose uptake and lactate production, and targeting aerobic glycolysis becomes a promising therapeutic approach for cancer. Here we reported that a small polyphenol resveratrol exhibited profound anti-tumor efficacy on human ovarian cancer. Resveratrol markedly inhibited the proliferation, migration, and invasion of A2780 and SKOV3 ovarian cancer cells, while impaired glycolysis, and induced apoptosis in these cells. Exposure to resveratrol increased the expression and activation of AMPK and Caspase 3, and decreased the expression and activation of AMPK downstream kinase mTOR...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663493/mouse-serum-exosomal-proteomic-signature-in-response-to-asbestos-exposure
#18
Phillip Munson, Ying-Wai Lam, Maximilian MacPherson, Stacie Beuschel, Arti Shukla
Asbestos-induced diseases like fibrosis and mesothelioma are very aggressive, without any treatment options. These diseases are diagnosed only at the terminal stages due to lack of early stage biomarkers. The recent discovery of exosomes as circulating biomarkers led us to look for exosomal biomarkers of asbestos exposure in mouse blood. In our model, mice were exposed to asbestos as a single bolus dose by oropharyngeal aspiration. Fifty-six days later blood was collected, exosomes were isolated from plasma and characterized and subjected to proteomic analysis using Tandem Mass Tag labeling...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663491/mir-370-inhibits-vascular-inflammation-and-oxidative-stress-triggered-by-oxidized-low-density-lipoprotein-through-targeting-tlr4
#19
Dan Tian, Yin Sha, Jing-Min Lu, Xian-Jin Du
Atherosclerosis, as a chronic cardiovascular disease, still remains a serious threat to human health. Inflammation and oxidative stress are commonly involved in various stages of atherosclerosis development. MicroRNAs are reported to play important roles in macrophages, which can respond to inflammation and oxidative stress. In our current study, we focused on the biological roles of miR-370 in atherosclerosis. According to the previously research, miR-370 was downregulated in AS mice models. Oxidized low-density lipoprotein (Ox-LDL) is regarded as a crucial regulator of atherosclerosis and we observed that miR-370 was decreased by ox-LDL dose-dependently and time-dependently in THP-1 cells...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663486/calmodulin-antagonist-enhances-dr5-mediated-apoptotic-signaling-in-tra-8-resistant-triple-negative-breast-cancer-cells
#20
Romone M Fancy, Harrison Kim, Tiara Napier, Donald J Buchsbaum, Kurt R Zinn, Yuhua Song
Patients with triple negative breast cancer (TNBC) have no successful "targeted" treatment modality, which represents a priority for novel therapy strategies. Upregulated death receptor 5 (DR5) expression levels in breast cancer cells compared to normal cells enable TRA-8, a DR5 specific agonistic antibody, to specifically target malignant cells for apoptosis without inducing normal hepatocyte apoptosis. Drug resistance is a common obstacle in TRAIL-based therapy for TNBC. Calmodulin (CaM) is overexpressed in breast cancer...
April 16, 2018: Journal of Cellular Biochemistry
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