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Journal of Cellular Biochemistry

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https://www.readbyqxmd.com/read/28328092/neferine-enhances-the-antitumor-effect-of-mitomycin-c-in-hela-cells-through-the-activation-of-p38-mapk-pathway
#1
Wassim Eid, Wafaa Abdel-Rehim
Current treatment options for patients with cervical cancer are far from desirable, with cervical cancer remaining to be one of the leading causes of cancer-related deaths; this highlights the need to formulate strategies that enhance the efficacy of available therapies. Mitomycin C (MMC) possesses antitumor effect in different cancers. However, the efficacy of MMC depends on other drugs in the combinational therapy and is often hampered by side-effects. Neferine, a natural alkaloid, exhibits antitumor effects in various cancers...
March 22, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28322470/anti-inflammatory-and-antioxidant-actions-of-copaiba-oil-are-related-to-liver-cell-modifications-in-arthritic-rats
#2
Cristiane V de Castro Ghizoni, Ana P Arssufi Ames, Osmar A Lameira, Ciomar A Bersani Amado, Anacharis B de Sá Nakanishi, Lívia Bracht, Maria R Marçal Natali, Rosane M Peralta, Adelar Bracht, Jurandir F Comar
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15 g · Kg(-1) , arthritic rats, and arthritic rats treated with copaiba oil (0...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28322466/the-role-of-mir-497-eif3a-axis-in-tgf%C3%AE-1-induced-epithelial-mesenchymal-transition-and-extracellular-matrix-in-rat-alveolar-epithelial-cells-and-pulmonary-fibroblasts
#3
Ren Guo, Yu Lv, Yang Ouyang, Siyu Liu, Dai Li
Multi-cause-induced interstitial lung disease, particularly pulmonary fibrosis, is a serious clinical concern. fibroblasts have been suggested to have a major role, with it recently being revealed that some of these fibroblasts are derived from alveolar epithelial cells through epithelial-mesenchymal transition (EMT). Eukaryotic translation initiation factor 3 subunit A (EIF3A) is a protein that in humans is encoded by the EIF3A gene, and has been suggested to play roles in regulating translation of a subset of mRNAs and in regulating cell cycle progression and cell proliferation...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28322462/stat1-inhibits-mir-181a-expression-to-suppress-colorectal-cancer-cell-proliferation-through-pten-akt
#4
Xingwen Zhang, Xiang Li, Fengbo Tan, Nanhui Yu, Haiping Pei
Signal transducers and activators of transcription 1 (STAT1) exhibits tumor-suppressor properties by inhibiting oncogenic pathways and promoting tumor immunosurveillance. MicroRNAs, a group of non-coding endogenous ones, may regulate gene expression and plays specific roles in tumorigenesis. Recently, miR-181a has been reported to be associated with poor prognosis of colorectal cancer (CRC). Using human colorectal cancer cell lines, we demonstrated that STAT1 suppresses both LoVo and SW480 cell growth by down-regulating miR-181a...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28322461/iodinated-tg-in-thyroid-follicular-lumen-regulates-ttf-1-and-pax8-expression-via-tsh-tshr-signaling-pathway
#5
Huibin Huang, Yaxiong Shi, Bo Liang, Huiyao Cai, Qingyan Cai
Our previous study showed that highly iodinated thyroglobulin (TG) inhibited thyroid transcription factor-1 (TTF-1) and paired box gene 8 (PAX8) expression, but the potential mechanism remains unclear. In this study, we constructed a thyroid follicle model in vitro to mimic its natural physiological structure and explored how iodinated TG in the follicular lumen tuned TTF-1 and PAX8 expression. Our data showed that lowly iodinated TG enhanced PKA activity while upregulation of both TTF-1 and PAX8 expression; and that highly iodinated TG triggered PKC activity while suppression of TTF-1 and PAX8 expression...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28322459/effects-of-microrna-19b-on-the-proliferation-apoptosis-and-migration-of-wilms-tumor-cells-via-the-pten-pi3k-akt-signaling-pathway
#6
Ge-Liang Liu, Han-Jie Yang, Bo Liu, Tian Liu
Wilms' tumor (WT) is a most common renal cancer that occurs among children, and microRNA-19b (miR-19b) usually participates in various human cancers. Importantly, the PTEN/PI3K/Akt signaling pathway plays a key role in cell apoptosis, growth and proliferation. Thus, our present study aims to investigate the effect of miR-19b on the PTEN/PI3K/Akt signaling pathway during WT cell proliferation, migration and apoptosis. WT tissues and adjacent normal tissues from WT patients were collected. qRT-PCR was applied to detect miR-19b expression in both the WT tissues and the adjacent normal tissues, immunohistochemistry was applied to detect the protein expressions of PTEN, P13K and p-Akt, SK-NEP-1 cells were divided into the blank, negative control (NC), miR-19b mimics and miR-19b inhibitors groups...
March 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28316107/applied-induced-pluripotent-stem-cells-in-combination-with-biomaterials-in-bone-tissue-engineering
#7
Abdolreza Ardeshirylajimi
Due to increasing of the orthopedic lesions and fractures in the world and limitation of current treatment methods, researchers and surgeons paid attention to the new treatment ways especially to tissue engineering and regenerative medicine. Innovation in stem cells and biomaterials accelerate during the last decade as two main important parts of the tissue engineering. Recently, induced pluripotent stem cells (iPSCs) introduced as cells with highly proliferation and differentiation potentials that hold great promising features for used in tissue engineering and regenerative medicine...
March 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28316102/tumor-suppressor-ptprj-is-a-target-of-mir-155-in-colorectal-cancer
#8
Xiao-Fei Zhang, Rongfu Tu, Keke Li, Pengxiang Ye, Xiaofeng Cui
PTPRJ is known for its antiproliferative role. Loss of heterozygosity (LOH) of PTPRJ has frequently been observed in various human cancers including colorectal cancer (CRC), lung cancer and breast cancer. However, the function and mechanism of PTPRJ in CRC is not well understood. At the present study, we show that ectopic expression of PTPRJ inhibits cell growth, migration and invasiveness in CRC cell line HCT116. Moreover, PTPRJ inhibits the tumorigenecity of HCT116 in a xenograft tumor model. MiR-155, the well-known oncomiR in CRC, is identified as an upstream factor of PTPRJ...
March 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28300289/dehydrocostus-lactone-suppresses-proliferation-of-human-chronic-myeloid-leukemia-cells-through-bcr-abl-jak-stat-signaling-pathways
#9
Hong Cai, Xiaosong Qin, Chunhui Yang
This study evaluates the anticancer effects of dehydrocostus lactone, a plant-derived sesquiterpene lactone, on human chronic myeloid leukemia cells. Dehydrocostus lactone significantly inhibits cell proliferation by inducing cells to undergo cell cycle arrest, apoptosis and differentiation. Dehydrocostus lactone suppresses the expression of cyclin B1, cyclin A, cyclin E, cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 1 (CDK2) and increases p21 expression, resulting in S-G2/M phase arrest in K562 cells...
March 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28300287/analysis-of-stroma-labeling-during-multiple-passage-of-a-sarcoma-imageable-patient-derived-orthotopic-xenograft-ipdox-in-red-fluorescent-protein-transgenic-nude-mice
#10
Tasuku Kiyuna, Takashi Murakami, Yasunori Tome, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Fuminori Kanaya, Arun Singh, Fritz C Eilber, Robert M Hoffman
A patient-derived orthotopic xenograft (PDOX) model of undifferentiated pleomorphic sarcoma (UPS) was previously established that acquired red fluorescent protein (RFP)-expressing stroma by growth in an RFP transgenic nude mouse. In the present study, an imageable PDOX model (iPDOX) of UPS was established by orthotopic implantation in the biceps femoris of transgenic RFP nude mice. After the tumors grew to a diameter of 10 mm, they were harvested and the brightest portion of the tumors were subsequently orthotopically transplanted to both RFP and non-colored nude mice...
March 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28300286/clinical-significance-and-prognosis-value-of-wnt-signaling-pathway-in-cervical-cancer
#11
Afsane Bahrami, Malihe Hasanzadeh, Soodabeh ShahidSales, Zohre Yousefi, Sima Kadkhodayan, Marjaneh Farazestanian, Mona Joudi Mashhad, Masoumeh Gharib, Seyed Mahdi Hassanian, Amir Avan
Cervical cancer is among the most commonly diagnosed cancer in women, supporting the need for identification of novel prognostic and predictive biomarkers to predict the risk of developing of this malignancy or predict the prognosis of patients. Against this background, the activation of the Wingless-type (Wnt)/β-catenin pathway has been suggested as the main dysregulated pathways, which is involved in the multistep process of cervical carcinogenesis, suggesting its value as a potential biomarker or therapeutic target...
March 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28300285/hx-1171-a-novel-nrf2-activator-induces-nqo1-and-hmox1-expression
#12
Jimin Kim, Su-Hyun Shin, Young-Eun Ko, Tokutaro Miki, Heung-Mo Bae, Jong-Koo Kang, Jae Wha Kim
HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a novel synthesized vitamin E derivative, which reportedly has positive effects on various diseases and conditions, such as liver fibrosis, hepatic cirrhosis, and cancer. In this study, we analyzed the transcriptional activity induced by HX-1171. Results from reverse transcription polymerase chain reaction and promoter assays reveal that HX-1171 increased the expression of NQO1 and HMOX1, encoding antioxidant-related enzymes, in A549 human lung epithelial cells...
March 16, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28294381/cd3-cd8-nkg2d-t-lymphocytes-induce-apoptosis-and-necroptosis-in-hla-negative-cells-via-fasl-fas-interaction
#13
O K Ivanova, T N Sharapova, E A Romanova, L P Sashchenko, D V Yashin
An important problem in cellular immunology is to identify new populations of cytotoxic lymphocytes capable of killing tumor cells that have lost classical components of MHC-machinery and to understand mechanisms of the death of these cells. We have previously found that CD4(+) CD25(+) lymphocytes appear in the lymphokine-activated killer (LAK) cell culture, which carry Tag7 (PGRP-S) and FasL proteins on their surface and can kill Hsp70- and Fas-expressing HLA-negative cells. In this work, we have continued to study the mechanisms of killing of the HLA-negative tumor cells, focusing this time on the CD8+ lymphocytes...
March 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295550/lncrna-malat-1-elevates-hmgb1-to-promote-autophagy-resulting-in-inhibition-of-tumor-cell-apoptosis-in-multiple-myeloma
#14
Da Gao, Zhen Xiao, Hui-Ping Li, Dong-Hai Han, Ya-Peng Zhang
BACKGROUND: Long non-coding RNAs (lncRNAs) can participate in the pathological process of multiple myeloma (MM) via regulation of specific gene expression and function. This research aimed to study the role of MALAT-1 and the underlying mechanism in MM. METHODS: In this study, the expression of MALAT-1 and HMGB1 protein in the bone marrow mononuclear cells from MM patients at different stages and in MM cell lines was determined by qRT-PCR and western blot, respectively...
March 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295543/lncrna-xist-promotes-pancreatic-cancer-proliferation-through-mir-133a-egfr
#15
Wei Wei, Yu Liu, Yebin Lu, Bo Yang, Ling Tang
According to recent studies, long non-coding RNA X-inactive specific transcript (XIST) is involved in the development and progression of many malignant tumors including pancreatic cancer. We validated the detailed role of XIST in human pancreatic cancer (PC) cell lines and PC tissues so as to determine its exact function and the mechanism by which it affected PC proliferation. In our research, lncRNA-XIST was specifically upregulated in PC tissues and cell lines, and high XIST expression in PC was related to poorer prognosis (larger tumor size, perineural invasion, lymph node micrometastases and shorter overall survival)...
March 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295540/v-atpases-containing-a3-subunit-play-a-direct-role-in-enamel-development-in-mice
#16
Lisa Johnson, Bernhard Ganss, Andrew Wang, Ralph A Zirngibl, Danielle E Johnson, Celeste Owen, Grace Bradley, Irina Voronov
Vacuolar H(+) -ATPases (V-ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of V-ATPases cause autosomal recessive osteopetrosis; a rare disease due to impaired bone resorption. Patients with osteopetrosis also display dental anomalies, such as enamel defects; however, it is not clear whether these enamel abnormalities are a direct consequence of the a3 mutations. We investigated enamel mineralization, spatiotemporal expression of enamel matrix proteins and the a3 protein during tooth development using an osteopetrotic mouse model with a R740S point mutation in the V-ATPase a3 subunit...
March 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295592/knockdown-of-long-non-coding-rna-zfas1-protects-cardiomyocytes-against-acute-myocardial-infarction-via-anti-apoptosis-by-regulating-mir-150-crp
#17
Tao Wu, Dan Wu, Qinghua Wu, Bing Zou, Xiao Huang, Xiaoshu Cheng, Yanqing Wu, Kui Hong, Ping Li, Renqiang Yang, Yunde Li, Yingzhang Cheng
BACKGROUND: ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement of ZFAS1 and its regulatory role in AMI. METHODS: In this study, the models of AMI rat and myocardial cell cultured under hypoxia were made. The expression of ZFAS1 and miR-150 of myocardial infarction tissue or cardiac myocytes was determined by quantitative real time PCR. The regulatory role of ZFAS1 on miR-150 was examined by RNA pull down assay...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295583/ameloblastin-upregulates-inflammatory-response-through-induction-of-il-1%C3%AE-in-human-macrophages
#18
Mai Otsuka, Toshinori Okinaga, Wataru Ariyoshi, Chiaki Kitamura, Tatsuji Nishihara
Ameloblastin (AMBN) is an enamel matrix protein that has various biological functions such as healing dental pulp and repairing bone fractures. In the present study, we clarified the effect of AMBN on the expression of an inflammatory cytokine, interleukin-1β (IL-1β) in lipopolysaccharide (LPS)-treated human macrophages. Real-time RT-PCR analysis showed that LPS treatment upregulated expression of the IL-1β gene in U937 cells. Interestingly, AMBN significantly enhanced IL-1β gene expression in LPS-treated U937 cells as well as the secretion of mature IL-1β into culture supernatants by these cells...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295507/crocin-suppresses-constitutively-active-stat3-through-induction-of-protein-tyrosine-phosphatase-shp-1
#19
Buyun Kim, Ki Yong Lee, Byoungduck Park
The aim of the present study is to investigate the effect of a natural compound crocin, one of the active components of saffron, on human multiple myeloma cells. Crocin effectively suppressed constitutive STAT3 activation, translocation of STAT3 to the nucleus, and its target gene expression. The suppression of STAT3 was mediated through the inhibition of activation of protein tyrosine kinases JAK1, JAK2 and c-Src. We found that crocin induced the expression of SHP-1, a tyrosine protein phosphatase, and pervanadate treatment reversed the crocin-induced downregulation of STAT3, suggesting the involvement of a protein tyrosine phosphatase...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28295503/nuclear-magnetic-resonance-structure-of-the-human-polyoma-jc-virus-agnoprotein
#20
Pascale Coric, A Sami Saribas, Magid Abou-Gharbia, Wayne Childers, Jon Condra, Martyn K White, Mahmut Safak, Serge Bouaziz
Agnoprotein is an important regulatory protein of the human polyoma JC virus (JCV) and plays critical roles during the viral replication cycle. It forms highly stable dimers and oligomers through its Leu/Ile/Phe-rich domain, which is important for the stability and function of the protein. We recently resolved the partial 3D structure of this protein by NMR using a synthetic peptide encompassing amino acids Thr17 to Gln52, where the Leu/Ile/Phe- rich domain was found to adopt a major alpha-helix conformation spanning amino acids 23 to 39...
March 10, 2017: Journal of Cellular Biochemistry
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