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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/30242471/-smart-resources-by-parul-ichhpujani-and-sahil-thakur-2018-springer-series-current-practices-in-ophthalmology-260-black-white-illustrations-419-illustrations-in-colour-isbn-978-981-13-0139-1-springer-singapore
#1
Bernd Kirchhof
No abstract text is available yet for this article.
September 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30238190/long-term-follow-up-of-pachychoroid-pigment-epitheliopathy-and-lesion-characteristics
#2
Murat Karacorlu, M Giray Ersoz, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas
AIMS: To investigate conversion of pachychoroid pigment epitheliopathy (PPE) lesions and the development of other pachychoroid spectrum diseases in patients with PPE during follow-up. METHODS: We retrospectively reviewed medical records of 46 eyes of 44 patients who had a diagnosis of PPE and were followed up for at least 3 years. RESULTS: Eyes with PPE (17.4%) developed central serous chorioretinopathy (CSC), and none developed pachychoroid neovasculopathy or polypoidal choroidal vasculopathy...
September 21, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30238189/flare-levels-after-intravitreal-injection-of-ranibizumab-aflibercept-or-triamcinolone-acetonide-for-diabetic-macular-edema
#3
Masakazu Morioka, Yoshihiro Takamura, Yutaka Yamada, Takehiro Matsumura, Makoto Gozawa, Masaru Inatani
PURPOSE: To evaluate anterior flare intensity (AFI) and central retinal thickness (CRT) values after intravitreal injection of aflibercept (IVA), ranibizumab (IVR), or triamcinolone acetonide (IVTA) in patients with diabetic macular edema (DME). METHODS: This research was conducted as a prospective study for patients with DME. Patients with phakia received either IVA or IVR, whereas patients with pseudophakia received IVA, IVR, or IVTA. AFI and CRT were measured using a laser flare meter and spectral domain optical coherence tomography, respectively, at days 0, 1, 7, 30, and 90...
September 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30229304/retinal-pigment-epithelium-hyperplasia-overlying-pigment-epithelial-detachment-in-age-related-macular-degeneration-can-masquerade-as-neovascularization-on-optical-coherence-tomography-angiography
#4
Ling Chen, Xiongze Zhang, Yuhong Gan, Bing Liu, Yuxin Zhang, Feng Wen
PURPOSE: To report the image artifacts due to retinal pigment epithelium (RPE) hyperplasia overlying retinal pigment epithelial detachment (PED) in age-related macular degeneration (AMD), which can masquerade as neovascularization on optical coherence tomography angiography (OCTA). METHODS: A hospital-based, retrospective, and cross-sectional study. Twenty-two eyes from 16 patients with non-vascularized PED related to AMD were included in this study. All patients were examined by OCTA, spectral-domain optical coherence tomography, fluorescence angiography, and indocyanine green angiography...
September 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30215097/a-new-immunodeficient-retinal-dystrophic-rat-model-for-transplantation-studies-using-human-derived-cells
#5
Biju B Thomas, Danhong Zhu, Tai-Chi Lin, Young Chang Kim, Magdalene J Seiler, Juan Carlos Martinez-Camarillo, Bin Lin, Yousuf Shad, David R Hinton, Mark S Humayun
PURPOSE: To create new immunodeficient Royal College of Surgeons (RCS) rats by introducing the defective MerTK gene into athymic nude rats. METHODS: Female homozygous RCS (RCS-p+/RCS-p+) and male nude rats (Hsd:RH-Foxn1mu , mutation in the foxn1 gene; no T cells) were crossed to produce heterozygous F1 progeny. Double homozygous F2 progeny obtained by crossing the F1 heterozygotes was identified phenotypically (hair loss) and genotypically (RCS-p+ gene determined by PCR)...
September 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30209568/relationship-between-filtering-bleb-vascularization-and-surgical-outcomes-after-trabeculectomy-an-optical-coherence-tomography-angiography-study
#6
Xue Yin, Qinhua Cai, Run Song, Xuefei He, Peirong Lu
PURPOSE: To explore the relationship between the bleb vasculature and surgical outcome after trabeculectomy (TRAB) using optical coherence tomography angiography (OCT-A). METHODS: A prospective study was conducted, which included 26 eyes of 26 primary glaucoma patients in the final analysis. Thereinto, six patients underwent TRAB combined 5-FU and 12 patients received subconjunctival 5-FU injection postoperation. The bleb vessel was evaluated using OCT-A 1 week, 2 weeks, 1 month, 3 months, and 6 months after TRAB...
September 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30209567/optical-coherence-tomography-angiography-assessment-of-the-macular-capillary-plexus-after-surgery-for-macula-off-rhegmatogenous-retinal-detachment
#7
LETTER
Naoko Yui, Hiroshi Kunikata, Naoko Aizawa, Toru Nakazawa
No abstract text is available yet for this article.
September 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30203105/assessment-of-ocular-microcirculation-in-patients-with-end-stage-kidney-disease
#8
Tetsushi Arimura, Tomoaki Shiba, Mao Takahashi, Shun Kumashiro, Hironori Osamura, Tadashi Matsumoto, Ken Sakai, Yuichi Hori
PURPOSE: To determine the impact that end-stage kidney disease (ESKD) has on ocular microcirculation in the optic nerve head (ONH) and choroid area shown by laser speckle flowgraphy (LSFG). METHODS: We studied 24 consecutive Japanese patients with ESKD who visited the department of Nephrology at our hospital and 55 age- and gender-matched subjects who had undergone polysomnography. The mean blur rates (MBRs) in vessels (MBR-Vessel), in the tissue (MBR-Tissue), throughout the ONH (MBR-All), and throughout the choroid (MBR-Choroid) were analyzed...
September 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30203104/improved-analysis-of-foveal-avascular-zone-area-with-optical-coherence-tomography-angiography
#9
Alexei N Kulikov, Dmitrii S Maltsev, Maria A Burnasheva
PURPOSE: To investigate the relationship between the foveal avascular zone (FAZ) and the inner nuclear layer (INL)-free zone in the center of the fovea in order to provide an improved approach to evaluation of the FAZ area with optical coherence tomography angiography (OCTA). METHODS: Thirty-six healthy individuals (36 eyes) and 15 age-matched patients (15 eyes) with nonproliferative diabetic retinopathy (nPDR) were included in this study. The FAZ, as well as INL-free zone, was measured on OCTA images...
September 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30203103/incidence-and-risk-of-ptosis-following-ocular-surgery-a-systematic-review-and-meta-analysis
#10
Yijie Wang, Lixia Lou, Zhifang Liu, Juan Ye
OBJECTIVE: We conducted a systematic review and meta-analysis to evaluate the incidence and risk factors of ptosis following ocular surgery. METHODS: PubMed, Embase, and Cochrane Library were searched for articles that assessed the incidence or risk factors of ptosis following ocular surgery up to October 2017. We used a fixed effects model to calculate a pooled estimate of incidence, with subgroup analyses to evaluate the effect of different variables. The relative risks (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) for all available factors were calculated using the fixed effects models...
September 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30196481/binocular-and-accommodative-function-in-the-controlled-randomized-clinical-trial-misight%C3%A2-assessment-study-spain-mass
#11
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Pilar Cañadas, Francisco Luis Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
PURPOSE: To evaluate the binocular and accommodative function in children wearing dual focus (DF) MiSight® contact lenses (CLs) for myopia control compared with children wearing single-vision (SV) spectacles. METHODS: This was a randomized, controlled clinical trial involving subjects aged 8 to 12, with myopia ranging from - 0.75 to - 4.00D and astigmatism < 1.00D, allocated to MiSight® study CLs group or control group wearing SV. Binocular and accommodative function was determined at baseline, 12-, and 24-month visits, assessed by the following sequence of tests: distance and near horizontal phoria, accommodative convergence/accommodation (AC/A) ratio, stereopsis, accommodative amplitude (AA), and accommodative response (AR) at 33, 25 and 20 cm...
September 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30196480/characteristics-and-risk-factors-of-recurrent-keratoconus-over-the-long-term-after-penetrating-keratoplasty
#12
Junko Yoshida, Hiroshi Murata, Takashi Miyai, Rika Shirakawa, Tetsuya Toyono, Satoru Yamagami, Tomohiko Usui
PURPOSE: To determine the characteristics and risk factors of recurrent keratoconus (KC) after penetrating keratoplasty (PK). METHODS: We enrolled patients who had maintained clear grafts for at least 10 years after PK based on their medical records. Patients were divided into the KC group or Others group based on the primary indication for PK. Each case was reviewed for clinically observed corneal ectasia. Steepest keratometric power (Ks), cylinder (CYL), and difference between Ks and minimum keratometric power (MinK) were analyzed in patients that underwent corneal topography more than three times after the 5th postoperative year...
September 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30191300/response-to-choroidal-thickness-changes-stratified-by-outcome-in-real-world-treatment-of-diabetic-macular-edema
#13
LETTER
António Campos, Elisa J Campos, Anália do Carmo, Rufino Silva
No abstract text is available yet for this article.
September 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30191299/retinal-flow-density-by-optical-coherence-tomography-angiography-is-useful-for-detection-of-nonperfused-areas-in-diabetic-retinopathy
#14
Yoshihiro Kaizu, Shintaro Nakao, Haruka Sekiryu, Iori Wada, Muneo Yamaguchi, Toshio Hisatomi, Yasuhiro Ikeda, Junji Kishimoto, Koh-Hei Sonoda
PURPOSE: Fluorescein angiography (FA) has been conventionally used for detection of retinal nonperfused area (NPA) in diabetic retinopathy (DR) in spite of its qualitative evaluation. Optical coherence tomography angiography (OCTA) has been recently reported to be useful for the quantification of retinal vascular disorder in DR. In this study, we examined whether retinal flow density (FD) measurement in OCTA was useful for NPA detection in DR. METHODS: The study included 41 eyes from 29 patients with DR who underwent FA and OCTA...
September 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30187129/choroidal-thickness-changes-stratified-by-outcome-in-real-world-treatment-of-diabetic-macular-edema
#15
LETTER
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
September 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30187128/pathological-changes-of-the-nasolacrimal-duct-in-rabbit-models-of-chronic-dacryocystitis-correlation-with-lacrimal-endoscopic-findings
#16
Rong Liu, Hongxun Li, Tao Ai, Weikun Hu, Ban Luo, Nan Xiang
PURPOSE: The aim of this study was to explore the pathological changes of the nasolacrimal duct in rabbits with experimentally induced obstructive dacryocystitis in correlation with lacrimal endoscopic findings. METHODS: The rabbit model of obstructive dacryocystitis was created by injecting 0.15 ml of self-curing resin into the lacrimal duct. The control group received 0.15 ml of normal saline. Within 16 weeks after the obstructive, lacrimal endoscopy and pathological examination of the nasolacrimal duct were conducted at different time points of 1, 2, 4, 8, and 16 weeks...
September 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30182295/application-of-srt-plus-mr-recession-in-supra-maximal-esotropia-from-chronic-sixth-nerve-palsy
#17
REVIEW
Yan Liu, Wen Wen, Leilei Zou, Sujia Wu, Shu Wang, Rui Liu, Hong Liu
BACKGROUND: To investigate prognostic factors in patients with augmented superior rectus transposition (SRT) for sixth nerve palsy. METHODS: Thirteen patients who were diagnosed with sixth nerve palsy and underwent augmented SRT between January 2015 and February 2017 in EENT Hospital of Fudan University were reviewed retrospectively. Data including age, sex, etiology of the abducens nerve palsy, degree of pre- and postoperative deviation in the primary position, pre- and postoperative abduction deficit, any induced vertical or torsional deviations, reoperations, and other complications was collected...
September 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30178140/detection-of-intrinsic-cholinergic-system-in-the-human-lacrimal-drainage-system-evidence-and-potential-implications
#18
Mohammad Javed Ali, Mareile Glóckner, Martin Schicht, Lars Bräuer, Friedrich Paulsen
PURPOSE: To investigate the presence and distribution of epithelial and non-epithelial cholinergic system and cholinergic brush cells in the human lacrimal drainage system. METHODS: The study was performed on fresh frozen human cadaveric samples of the lacrimal drainage system. Immunohistochemistry was performed for assessing the presence and distribution of cholinergic brush cell proteins-villin, acetylcholine synthesizing enzyme, choline acetyltransferase (ChAT); vesicular acetylcholine transporter (VAChT); components of canonical taste transduction signaling cascade, phospholipase C β2 (PLCβ2), and transient receptor potential cation channel, subfamily M, and member 5 (TRPM5)...
September 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30178139/an-investigation-on-optic-nerve-head-involvement-in-fuchs-uveitis-syndrome-using-optical-coherence-tomography-and-fluorescein-angiography
#19
Mohammad Zarei, Ali Abdollahi, Sahel Darabeigi, Nazanin Ebrahimiadib, Ramak Roohipoor, Hamed Ghassemi, Reza Soltani Moghaddam, Masoud Aghsaei Fard
PURPOSE: To investigate optic nerve head involvement in patients with Fuchs uveitis syndrome (FUS). METHODS: Optic nerve head of 43 FUS eyes without clinical optic disc edema and 37 unaffected fellow eyes were evaluated using optical coherence tomography (OCT) of peripapillary retina and retinal nerve fiber layer (RNFL) and fundus fluorescein angiography. RESULTS: Seventy-one percent of FUS eyes showed optic nerve head hyperfluorescence. The mean average RNFL thickness in FUS eyes was 115...
September 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/30175386/the-role-of-oct-a-in-retinal-disease-management
#20
REVIEW
Francisco J Rodríguez, Giovanni Staurenghi, Richard Gale
Optical coherence tomography angiography (OCT-A) is a non-invasive, non-dye-based imaging modality that has the potential to enhance our understanding of retinal diseases. While this rapidly advancing imaging modality offers great potential, there is a need for community-wide understanding of the range of technologies and methods for interpreting the images, as well as a need to enhance understanding of images from disease-free eyes for reference when screening for retinal diseases. Importantly, clinical trials have been designed without OCT-A-based endpoints; therefore, caution is required when making treatment decisions based on OCT-A imaging alone...
September 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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