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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28110356/predicting-conversion-to-glaucoma-using-standard-automated-perimetry-and-frequency-doubling-technology
#1
Genichiro Takahashi, Shaban Demirel, Chris A Johnson
PURPOSE: To test the hypothesis that development of glaucomatous visual fields can be predicted several years earlier from prior visual field information. METHODS: One-hundred and seven eyes with glaucomatous optic neuropathy (n = 47 eyes) or which were suspicious for glaucoma (n = 60) were prospectively enrolled in a longitudinal study. Visual fields were evaluated on an annual basis using standard automated perimetry (SAP), the original version of frequency doubling technology (FDT) perimetry, and a custom version of FDT that used the 24-2 stimulus pattern...
January 21, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28102456/efficacy-and-safety-of-a-fixed-bimonthly-ranibizumab-treatment-regimen-in-eyes-with-neovascular-age-related-macular-degeneration-results-from-the-rabimo-trial
#2
Nicolas Feltgen, Thomas Bertelmann, Mirko Bretag, Sebastian Pfeiffer, Reinhard Hilgers, Josep Callizo, Lena Goldammer, Sebastian Bemme, Hans Hoerauf
PURPOSE: To evaluate prospectively the efficacy and safety of a fixed bimonthly ranibizumab treatment regimen (RABIMO) in eyes with neovascular age-related macular degeneration (nAMD) and to compare these results with a pro re nata (PRN) treatment scheme. METHODS: This was a 12-month, phase IV, single center, randomised, non-inferiority study. Following three initial monthly injections, patients were randomised to receive either ranibizumab bimonthly (RABIMO group) or ranibizumab PRN (PRN group) (n = 20 each)...
January 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28102455/soluble-form-of-lr11-is-highly-increased-in-the-vitreous-fluids-of-patients-with-idiopathic-epiretinal-membrane
#3
Ryuya Hashimoto, Meizi Jiang, Tomoaki Shiba, Nobuyuki Hiruta, Mao Takahashi, Morihiro Higashi, Yuichi Hori, Hideaki Bujo, Takatoshi Maeno
PURPOSE: LR11 (also called SorLA or SORL1) is a migration regulator of adherent cells with the immature proliferative phenotype. The present study investigated the clinical and pathological involvement of the soluble form of LR11 (sLR11) in the idiopathic epiretinal membrane (iERM). METHODS: The subjects were 51 patients with iERM (24 cellophane macular reflex (CMR) and 27 preretinal macular fibrosis (PMF)) and 45 patients with macular holes as age and sex-matched controls...
January 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28101654/cell-viability-and-shock-wave-amplitudes-in-the-endothelium-of-porcine-cornea-exposed-to-ultrashort-laser-pulses
#4
Syed Asad Hussain, Carles Milián, Caroline Crotti, Laura Kowalczuk, Fatima Alahyane, Zacaria Essaïdi, Arnaud Couairon, Marie-Claire Schanne-Klein, Karsten Plamann
PURPOSE: Some forms of keratoplasty assisted by ultrashort-pulse lasers require performing laser cuts close to the endothelium, which requires the knowledge of "safe" values concerning incision depth and pulse energy preserving endothelial cell viability. Our study aims to determine the thresholds for cell death in porcine corneas exposed to ultrashort laser pulses, in terms of laser pulse energy and nearness of the impacts to the endothelium. METHODS: Using a laboratory laser set-up, lamellar cuts were induced while varying pulse energies and distances from the endothelium...
January 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28097437/two-and-three-dimensional-topographic-analysis-of-pathologically-myopic-eyes-with-dome-shaped-macula-and-inferior-staphyloma-by-spectral-domain-optical-coherence-tomography
#5
Antonio García-Ben, Radua Kamal-Salah, Ignacio García-Basterra, Ana Gonzalez Gómez, María José Morillo Sanchez, Jose Manuel García-Campos
PURPOSE: To investigate the posterior anatomical structure of pathologically myopic eyes with dome-shaped macula and inferior staphyloma using spectral domain optical coherence tomography (SD-OCT). METHODS: Our database of 260 pathologically myopic eyes was analyzed retrospectively to identify patients with dome-shaped macula and inferior staphyloma. All patients underwent vertical and horizontal SD-OCT scans across the central fovea, with three-dimensional macular map reconstruction...
January 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28091782/adaptation-perceptual-learning-and-plasticity-of-brain-functions
#6
REVIEW
Jonathan C Horton, Manfred Fahle, Theo Mulder, Susanne Trauzettel-Klosinski
The capacity for functional restitution after brain damage is quite different in the sensory and motor systems. This series of presentations highlights the potential for adaptation, plasticity, and perceptual learning from an interdisciplinary perspective. The chances for restitution in the primary visual cortex are limited. Some patterns of visual field loss and recovery after stroke are common, whereas others are impossible, which can be explained by the arrangement and plasticity of the cortical map. On the other hand, compensatory mechanisms are effective, can occur spontaneously, and can be enhanced by training...
January 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28091781/a-semifluorinated-alkane-f4h5-as-novel-carrier-for-cyclosporine-a-a-promising-therapeutic-and-prophylactic-option-for-topical-treatment-of-dry-eye
#7
Uta Gehlsen, Tobias Braun, Maria Notara, Sonja Krösser, Philipp Steven
PURPOSE: Cyclosporine A (Cs) has been used as effective topical therapy for inflammatory dry eye disease since more than a decade. However, due to its lipophilic character, Cs is formulated as emulsions or oily solutions for topical application. This experimental study aimed to test if the use of semifluorinated alkanes (SFAs) as a preservative-free, well-tolerated non-stinging or burning vehicle maintains or even improves the benefits of Cs in the topical therapy of dry-eye disease. METHODS: Desiccating stress was applied to C57BL/6 mice for 14 consecutive days to induce experimental dry-eye...
January 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28091780/letter-in-response-to-letter-intraocular-use-of-acid-violet-17-at-a-concentration-of-1-5%C3%A2-mg-ml-is-not-safe-by-professor-heinrich-gerding-department-of-ophthalmology-pallas-kliniken
#8
LETTER
David H Steel
No abstract text is available yet for this article.
January 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28083679/the-effects-of-pleiotrophin-in-proliferative-vitreoretinopathy
#9
Xue Ding, Yujing Bai, Xuemei Zhu, Tianqi Li, Enzhong Jin, Lvzhen Huang, Wenzhen Yu, Mingwei Zhao
PURPOSE: The purpose of our study was to investigate the effects of pleiotrophin (PTN) in proliferative vitreoretinopathy (PVR) both in vitro and in vivo. METHODS: Immunofluorescence was used to observe the PTN expression in periretinal membrane samples from patients with PVR and controls. ARPE-19 cells were exposed to TGF-β1. The epithelial-to-mesenchymal transition (EMT) of the ARPE-19 cells was confirmed by observed morphological changes and the increased expression of α-SMA and fibronectin at both the mRNA and protein levels...
January 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28083678/intraocular-use-of-acid-violet-17-at-a-concentration-of-1-5%C3%A2-mg-ml-is-not-safe
#10
LETTER
Heinrich Gerding
No abstract text is available yet for this article.
January 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28078427/response-to-the-comment-on-the-biomechanical-properties-of-the-cornea-of-patients-with-glaucoma-treated-with-anti-glaucoma-topical-medication
#11
LETTER
Karin R Pillunat, Cosima Hermann, Eberhard Spoerl, Lutz E Pillunat
No abstract text is available yet for this article.
January 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28074262/activated-microglia-induce-the-production-of-reactive-oxygen-species-and-promote-apoptosis-of-co-cultured-retinal-microvascular-pericytes
#12
Xinyi Ding, Meng Zhang, Ruiping Gu, Gezhi Xu, Haixiang Wu
PURPOSE: Pericyte apoptosis is a predominant feature of early diabetic retinopathy. In diabetic retinopathy, activated microglia migrate and release proinflammatory cytokines that contribute to disruption of the blood-retinal barrier, neuronal loss, and enhanced ROS production. Reactive oxygen species (ROS) are implicated in pericyte death; however, the mechanism by which activated microglia affect retinal microvascular pericytes is unclear. We hypothesized that activated microglia may promote pericyte apoptosis by enhancing ROS production...
January 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28063082/vitrectomy-for-complications-of-proliferative-diabetic-retinopathy-in-young-adults-clinical-features-and-surgical-outcomes
#13
Chu-Hsuan Huang, Yi-Ting Hsieh, Chung-May Yang
PURPOSE: To investigate the clinical manifestations and surgical results after vitrectomy for proliferative diabetic retinopathy (PDR) in young patients. METHODS: Clinical features of patients between 18 to 40 years old who received vitrectomy for PDR between January 2009 and January 2015 were retrospectively reviewed. Those older than 40 years who received vitrectomy for PDR during the same period were retrospectively enrolled and compared as the control group...
January 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28058508/the-biomechanical-properties-of-the-cornea-of-patients-with-glaucoma-treated-with-anti-glaucoma-topical-medications
#14
LETTER
Chong-Da Chen, Hui Chen, Lin Miao
No abstract text is available yet for this article.
January 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28013393/ngf-anti-vegf-combined-exposure-protects-rcs-retinal-cells-and-photoreceptors-that-underwent-a-local-worsening-of-inflammation
#15
Maria Luisa Rocco, Bijorn Omar Balzamino, Graziana Esposito, Carla Petrella, Luigi Aloe, Alessandra Micera
PURPOSE: Our previous study highlighted the potential nerve growth factor (NGF) effect on damaged photoreceptors from a rat model of spontaneous Retinitis Pigmentosa (RP). Herein, we tested the combined NGF/anti-vascular endothelial growth factor (αVEGF) effect on cultured retinal cells isolated from Royal College of Surgeons (RCS) rats receiving an intravitreal VEGF injection (iv-VEGF) to exacerbate retinal inflammation/neovascularization. METHODS: RCS (n = 75) rats were equally grouped as untreated (n = 25), iv-saline (single saline intravitreal injection; n = 25) and iv-VEGF (single VEGF intravitreal injection; n = 25)...
December 24, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28013392/the-clinical-depth-of-field-achievable-with-trifocal-and-monofocal-intraocular-lenses-theoretical-considerations-and-proof-of-concept-clinical-results
#16
Ante Barišić, Sudi Patel, Nikica Gabric, Claes G Feinbaum
BACKGROUND: To estimate the depth of field (DOF) achievable with multi-and monofocal intraocular lenses (IOLs) and compare with actual measurements of DOF in cases implanted with a trifocal IOL and biconvex monofocal IOL METHODS: I) Computer simulations were produced to describe the relationship between DOF, pupil size, preoperative ametropia, and retinal blur tolerance limit for a model eye implanted with either multi- or monofocal IOLs. II) Monocular DOF and pupil size were measured under distance viewing conditions between 3 and 6 months postoperative following uneventful cataract surgery...
December 24, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28013391/laser-pointers-how-much-does-the-general-medical-community-know
#17
LETTER
Sulaiman M Alsulaiman, Abdullah Al-Qahtani, Ahmed Mousa, Nicola G Ghazi
No abstract text is available yet for this article.
December 24, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28004197/poor-outcomes-despite-aspirin-or-statin-use-in-high-risk-patients-with-retinal-vein-occlusion
#18
Vlad M Matei, Jonathan Y Xia, Chan Nguyen
PURPOSE: Since atherosclerosis contributes to the pathophysiology of retinal vein occlusion (RVO), we aimed to assess the effects of aspirin and statins on the visual outcomes of RVO in high-risk patients, whom we define to have hypertension and open-angle glaucoma prior to RVO. METHODS: We conducted a retrospective case-control study of adults diagnosed with RVO between 2006 and 2014. To evaluate for a preventive effect of these medications, we compared the prevalence of aspirin or statin use (either separately or concomitantly) among high-risk patients who developed RVO and among those who did not during at least 2 years of follow-up...
December 21, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28004196/a-method-for-identifying-color-vision-deficiency-malingering
#19
Andrew Pouw, Rustum Karanjia, Alfredo Sadun
PURPOSE: To propose a new test to identify color vision deficiency malingering. METHODS: An online survey was distributed to 130 truly color vision deficient participants and 160 participants willing to simulate color vision deficiency. The survey contained three sets of six color-adjusted versions of the standard Ishihara color plates each, as well as one set of six control plates. The plates that best discriminated both participant groups were selected for a "balanced" test emphasizing both sensitivity and specificity...
December 21, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27957601/reply-to-a-letter-to-the-editor-dexamethasone-intravitreal-implant-in-retinal-vein-occlusion-real-life-data-from-a-prospective-multicenter-clinical-trial
#20
LETTER
Nicole Eter, Andreas Mohr, Joachim Wachtlin, Nicolas Feltgen
No abstract text is available yet for this article.
December 13, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
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