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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28229218/microbial-flora-and-resistance-in-ophthalmology-a-review
#1
REVIEW
Andrzej Grzybowski, Piotr Brona, Stephen Jae Kim
Antibiotic resistance in systemic infection is well-researched and well-publicized. Much less information is available on the resistance of normal ocular microbiome and that of ophthalmic infections. An understanding of the distribution of ocular microorganisms may help us in tailoring our empiric treatment, as well as in choosing effective pre-, peri- and postoperative management, to achieve the best results for patients. This study aims to summarize and review the available literature on the subject of normal ocular flora and its resistance, as well as the broader topic of antibiotic resistance in ophthalmology...
February 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28224290/pediatric-ocular-trauma-score-as-a-prognostic-tool-in-the-management-of-pediatric-traumatic-cataracts
#2
Mehul A Shah, Rupesh Agrawal, Ryan Teoh, Shreya M Shah, Kashyap Patel, Satyam Gupta, Siddharth Gosai
OBJECTIVE: To introduce and validate the pediatric ocular trauma score (POTS) - a mathematical model to predict visual outcome trauma in children with traumatic cataract METHODS: In this retrospective cohort study, medical records of consecutive children with traumatic cataracts aged 18 and below were retrieved and analysed. Data collected included age, gender, visual acuity, anterior segment and posterior segment findings, nature of surgery, treatment for amblyopia, follow-up, and final outcome was recorded on a precoded data information sheet...
February 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28224289/two-different-techniques-for-frontalis-suspension-using-gore-tex-to-treat-severe-congenital-ptosis
#3
Adel Galal Zaky, Sameh Saad Mandour, Marwa Aly Zaky, Asmaa Mohamed Ebrahem
PURPOSE: Severe congenital ptosis is commonly associated with poor levator function. This study compares the functional and cosmetic outcomes of open versus closed frontalis sling using Gore-Tex in the treatment of such conditions. METHODS: Randomized interventional comparative case series of 20 eyes of 13 patients with severe congenital ptosis with levator excursion < 4 mm. Patients were treated by frontalis suspension using Gore-Tex string sutures either through a skin crease incision (group 1) or supraciliary incisions (group II)...
February 21, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28224288/predictive-factors-for-functional-improvement-following-intravitreal-bevacizumab-injections-after-central-retinal-vein-occlusion
#4
LETTER
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
February 21, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28224287/predictive-factors-for-functional-improvement-following-intravitreal-bevacizumab-injections-after-central-retinal-vein-occlusion
#5
LETTER
Gesine B Szurman, Carsten H Meyer, Nicolas Feltgen, Amelie Pielen, Bernhard Spitzer, Matus Rehak, Georg Spital, Spyridon Dimopoulos, Peter Szurman, Kai Januschowski
No abstract text is available yet for this article.
February 21, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28220252/long-term-surgical-outcomes-of-the-inverted-internal-limiting-membrane-flap-technique-in-highly-myopic-macular-hole-retinal-detachment
#6
Taiga Kinoshita, Yasutaka Onoda, Takatoshi Maeno
BACKGROUND: Pars plana vitrectomy (PPV) procedures are used for the surgical treatment of macular hole retinal detachment (MHRD) associated with high myopia. Re-detachment of the retina has been reported in MHRD associated with high myopia. Our aim was to evaluate the 1-year outcomes of vitrectomy, performed using an inverted internal limiting membrane (ILM) flap technique with gas tamponade, in five cases of MHRD associated with high myopia. METHODS: We performed a retrospective review of medical records of five consecutive cases of highly myopic MHRD...
February 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28214955/ranibizumab-versus-aflibercept-for-macular-edema-due-to-central-retinal-vein-occlusion-18-month-results-in-real-life-data
#7
Irini Chatziralli, George Theodossiadis, Marilita M Moschos, Panagiotis Mitropoulos, Panagiotis Theodossiadis
PURPOSE: The objective of this study was to compare the anatomical and functional outcomes of ranibizumab versus aflibercept for the treatment of macular edema due to central retinal vein occlusion (CRVO) in routine clinical practice. METHODS: Participants in this observational study included 62 treatment-naïve patients with CRVO who received intravitreal injections of either ranibizumab or aflibercept. The demographic data, best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) characteristics were evaluated at baseline and at months 1, 2, 3, 6, 12 and 18 post-treatment...
February 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28214954/association-of-toll-like-receptor-4-single-nucleotide-polymorphisms-asp299gly-and-thr399ile-with-the-risk-of-primary-open-angle-glaucoma
#8
Jose Navarro-Partida, Abril Bernardette Martinez-Rizo, Pedro Ramirez-Barrera, Jesus Bernardino Velazquez-Fernandez, Veronica A Mondragon-Jaimes, Arturo Santos-Garcia, Veronica Benites-Godinez
PURPOSE: Toll-like receptor 4 (TLR4) is a transmembrane receptor that mediates immune responses to exogenous and endogenous ligands. Previously, non-coding single nucleotide polymorphisms (SNPs) in the TLR4 gene were related to primary open angle glaucoma (POAG). This study was undertaken to investigate whether coding TLR4 Asp299Gly (rs4986790 A/G) and Thr399Ile (rs4986791 C/T) are associated with POAG in a Mexican population. METHODS: One hundred and eighty-seven unrelated Mexican patients with POAG (94 men and 95 women; mean age 66...
February 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28213628/a-conjunctival-and-choroidal-melanoma-in-the-same-eye-report-of-two-cases
#9
LETTER
Ido D Fabian, Caroline Thaung, Victoria M L Cohen
No abstract text is available yet for this article.
February 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28190192/letter-to-the-editor-comparison-of-specular-microscopy-and-ultrasound-pachymetry-before-and-after-cataract-surgery
#10
LETTER
Alberto López-Miguel, María Sanchidrián, Itziar Fernández, Alfredo Holgueras, Miguel J Maldonado
No abstract text is available yet for this article.
February 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28190191/inter-method-agreement-in-retinal-blood-vessels-diameter-analysis-between-dynamic-vessel-analyzer-and-optical-coherence-tomography
#11
Lucia Benatti, Federico Corvi, Livia Tomasso, Stefano Mercuri, Lea Querques, Fulvio Ricceri, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyze the inter-methods agreement in arteriovenous ratio (AVR) evaluation between spectral-domain optical coherence tomography (SD-OCT) and Dynamic Vessel Analyzer (DVA). METHODS: Healthy volunteers underwent DVA and SD-OCT examination. AVR was measured by SD-OCT using the four external lines of the optic nerve head-centered 7-line cube and by DVA using an automated AVR estimation. The mean AVR was calculated, twice, separately by two independent readers for each tool...
February 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28176011/implantation-of-a-second-glaucoma-drainage-device
#12
Brian A Francis, Rodrigo A B Fernandes, Handan Akil, Vikas Chopra, Bruno Diniz, James Tan, Alex Huang
PURPOSE: To evaluate success rates in controlling intraocular pressure (IOP) after implantation of a second glaucoma drainage device (GDD) with a Baerveldt glaucoma implant in patients with refractory glaucoma, with a secondary aim of reducing the need for postoperative glaucoma medications. MATERIAL AND METHODS: This retrospective, noncomparative, interventional study included patients undergoing a second GDD for uncontrolled glaucoma from a tertiary care glaucoma service...
February 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28168584/thank-you-list-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
February 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28161831/peripapillary-retinal-vessel-density-in-eyes-with-acute-primary-angle-closure-an-optical-coherence-tomography-angiography-study
#14
Xiaolei Wang, Chunhui Jiang, Xiangmei Kong, Xiaobo Yu, Xinghuai Sun
PURPOSE: The purpose was to investigate peripapillary retinal vessel density in resolved acute primary angle closure (APAC) eyes. METHODS: This was a prospective, cross-sectional observational study. Thirty-four eyes of 34 patients with unilateral APAC were included, together with the fellow eyes with primary angle closure suspect (PACS) as controls. Peripapillary retinal vessel density was measured using optical coherence tomography (OCT) angiography. Peripapillary retinal vessel density was compared in both eyes and the potential relationship with visual field (VF) test results was evaluated...
February 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28161830/combined-vegf-and-pdgf-inhibition-for-neovascular-amd-anti-angiogenic-properties-of-axitinib-on-human-endothelial-cells-and-pericytes-in-vitro
#15
Jakob Siedlecki, Christian Wertheimer, Armin Wolf, Raffael Liegl, Claudia Priglinger, Siegfried Priglinger, Kirsten Eibl-Lindner
PURPOSE: Drugs currently approved for neovascular age-related macular degeneration (nAMD) offer anti-VEGF monotherapy only. Platelet-derived growth factor (PDGF) signaling is pivotal to pericyte-induced stabilization of choroidal neovascularizations (CNV), and causes partial anti-VEGF resistance. No combination therapy for VEGF and PDGF has been approved yet. Axitinib is a tyrosine kinase inhibitor interfering with VEGF and PDGF signaling, and has been approved for the treatment of renal cell carcinoma...
February 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28161829/effect-of-oral-niacin-on-central-retinal-vein-occlusion
#16
Michael W Gaynon, Yannis M Paulus, Ehsan Rahimy, Janet L Alexander, Sam E Mansour
PURPOSE: Niacin, a treatment for dyslipidemia, is known to induce vasodilation as a secondary effect. Previous instances of patients with chronic central retinal vein occlusion (CRVO) and cystoid macular edema (CME) have been observed to spontaneously improve when placed on systemic niacin for hypercholesterolemia. The purpose of this study was to evaluate the effects of niacin on CRVO and associated ocular complications. METHODS: A prospective, single-center, non-randomized, interventional case series of niacin for CRVO was conducted...
February 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28161828/macular-hole-closure-patterns-associated-with-different-internal-limiting-membrane-flap-techniques
#17
Tommaso Rossi, Aldo Gelso, Ciro Costagliola, Carlandrea Trillo, Annalisa Costa, Carlo Gesualdo, Guido Ripandelli
PURPOSE: To compare the anatomic and functional outcome of two variants of the inverted internal limiting membrane (I-ILM) flap technique for idiopathic macular holes (IMH) larger than 400 µm. METHODS: Twenty-seven consecutive patients undergoing PPV for IMH were randomly assigned to different variants of I-ILM technique: the Cover group included 14 patients in which the I-ILM was folded upside-down over the MH as a single layer while the Fill group enrolled 13 patients in which the I-ILM was folded within the MH in multiple layers...
February 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28160068/descemet-membrane-endothelial-keratoplasty-for-graft-failure-following-penetrating-keratoplasty
#18
Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thabo Lapp, Thomas Reinhard, Philip Maier
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) is superior to penetrating keratoplasty (PK) in terms of visual rehabilitation, intraoperative safety and risk of rejection. Therefore, it seems reasonable to perform DMEK in eyes with endothelial failure following PK. We herein report our first clinical results. METHODS: Nineteen eyes with endothelial graft failure following PK were treated with DMEK. The majority of these eyes (12) had limited visual potential...
February 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28154932/rituximab-in-the-treatment-of-ocular-cicatricial-pemphigoid-a-retrospective-cohort-study
#19
Caiyun You, Neerav Lamba, Andres F Lasave, Lina Ma, Mikhail Hernandez Diaz, C Stephen Foster
PURPOSE: The purpose was to evaluate the effectiveness and safety of rituximab (RTX) for the treatment of patients with aggressive ocular cicatricial pemphigoid (OCP). METHODS: A review of patient records at a tertiary referral center with biopsy confirmed OCP who presented between 2006 and 2016. Sixty-one eyes of 32 patients with symptomatic OCP who received treatment with RTX monotherapy or RTX in combination with additional immunomodulatory treatment (IMT) were evaluated...
February 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28154931/comparison-of-specular-microscopy-and-ultrasound-pachymetry-before-and-after-cataract-surgery
#20
LETTER
Maddalena De Bernardo, Nicola Rosa
No abstract text is available yet for this article.
February 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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