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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/29777305/the-distribution-of-retinal-nerve-fiber-layer-thickness-and-associations-with-age-refraction-and-axial-length-the-gutenberg-health-study
#1
Esther M Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K Schuster, Manfred E Beutel, Norbert Pfeiffer, Julia Lamparter
PURPOSE: To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting. METHODS: In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany)...
May 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29774418/prevalence-of-glaucoma-in-germany-results-from-the-gutenberg-health-study
#2
René Höhn, Stefan Nickels, Alexander K Schuster, Philipp S Wild, Thomas Münzel, Karl J Lackner, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer
PURPOSE: To determine the prevalence of glaucoma according to the International Society for Geographical and Epidemiological Ophthalmology (ISGEO) classification in an adult German cohort. METHODS: The Gutenberg Health Study is a population-based, prospective cohort study in the Rhine-Main Region in mid-western Germany with a total of 15,010 participants. In this study, the first 5000 subjects with an age range between 35 and 74 years were included. Optic disk pictures were obtained by a non-mydriatic fundus camera (Visucam™) and analyzed using the Visupac™ software...
May 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29754292/investigation-of-retinal-nerve-fiber-layer-thickness-and-ganglion-cell-layer-inner-plexiform-layer-thickness-in-patients-with-optic-pathway-gliomas
#3
Mustafa Hepokur, Ahmet Murat Sarici
PURPOSE: This study aimed to compare the optical coherence tomography (OCT) findings of optic pathway glioma (OPG) patients (sporadic or secondary to neurofibromatosis type 1, NF1) with NF1 without OPG patients and healthy controls. METHODS: This was a prospective, case-control study in which 27 patients (13 with OPGs and 14 with NF1 without OPGs) and 13 control subjects were included. The retinal nerve fiber layer (RNFL) thickness, macular thickness, and ganglion cell layer-inner plexiform layer (GCL-IPL) thickness findings measured using OCT and the results were compared between the groups...
May 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29744575/small-incision-levator-resection-for-correction-of-congenital-ptosis-a-prospective-study
#4
Bahram Eshraghi, Hadi Ghadimi
PURPOSE: To determine the rate of success of small-incision levator resection technique for correction of congenital ptosis. METHODS: Patients with congenital ptosis who were candidates for levator resection were enrolled if their levator function was not poor (< 5 mm). Incisions were made on upper eyelid crease with a length of 10-12 mm. After resection of adequate length of levator muscle, two sutures were used to fix it to tarsal plate. Sliding the incision to medial and lateral sides provided a wider field of access to allow the surgeon to place the sutures above nasal and temporal borders of limbus...
May 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29744574/past-and-prognosis-of-anti-vegf-therapy-for-wet-age-related-macular-degeneration-the-future-has-begun
#5
LETTER
Justus G Garweg, J J Zirpel, C Gerhardt, Isabel B Pfister
No abstract text is available yet for this article.
May 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29737416/long-term-follow-up-of-deep-anterior-lamellar-keratoplasty-after-descemet-stripping-automated-endothelial-keratoplasty
#6
Matthias Fuest, Sharita R Siregar, Abdelsattar Farrag, Hla Myint Htoon, Donald Tan, Jodhbir S Mehta
AIMS: To describe the long-term outcomes of deep anterior lamellar keratoplasty (DALK) performed after Descemet stripping automated endothelial keratoplasty (DSAEK) in cases of infection and residual stromal opacity. METHODS: Ten eyes of nine consecutive patients undergoing DALK after DSAEK at a single tertiary referral center (SNEC) from 2011 to 2016 were analyzed for best spectacle-corrected visual acuity (BSCVA), refraction, spherical equivalent (SE) and cylinder, as well as graft diameters, survival, and complications...
May 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29732469/the-fate-of-eyes-with-wet-amd-beyond-4-years-of-anti-vegf-therapy
#7
LETTER
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
May 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29732468/clinical-characteristics-of-chronic-central-serous-chorioretinopathy-patients-with-insufficient-response-to-reduced-settings-photodynamic-therapy
#8
Thomas J van Rijssen, Elon H C van Dijk, Greet Dijkman, Camiel J F Boon
PURPOSE: To identify characteristics of Caucasian chronic central serous chorioretinopathy (cCSC) patients without a complete resolution of subretinal fluid (SRF) after reduced-settings photodynamic therapy (PDT), or with a recurrence of SRF after PDT. METHODS: Chronic CSC patients treated with reduced-settings PDT were divided into a successful PDT group and unsuccessful PDT group. Patients in the successful PDT group did not have any subretinal fluid (SRF) during follow-up after PDT, whereas the unsuccessful PDT group was categorized based on either persistence or recurrence of SRF after PDT treatment...
May 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29730798/effects-of-an-infratrochlear-nerve-block-on-reducing-the-oculocardiac-reflex-during-strabismus-surgery-a-randomized-controlled-trial
#9
Seung-Hyun Kim, Hyun Jin Shin
PURPOSE: To determine whether an infratrochlear nerve block (ITB) can reduce the oculocardiac reflex (OCR) during strabismus surgery on the medial rectus muscle (MR). METHODS: This prospective, randomized single-masked study included 60 patients with intermittent exotropia scheduled for unilateral MR resection/lateral rectus recession under general anesthesia. Patients were randomly allocated to receive a regional nerve block of the infratrochlear nerve (ITB group) prior to surgery or standard treatment without a nerve block (control group)...
May 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29730797/developing-an-item-bank-to-measure-the-coping-strategies-of-people-with-hereditary-retinal-diseases
#10
Mallika Prem Senthil, Jyoti Khadka, John De Roach, Tina Lamey, Terri McLaren, Isabella Campbell, Eva K Fenwick, Ecosse L Lamoureux, Konrad Pesudovs
PURPOSE: Our understanding of the coping strategies used by people with visual impairment to manage stress related to visual loss is limited. This study aims to develop a sophisticated coping instrument in the form of an item bank implemented via Computerised adaptive testing (CAT) for hereditary retinal diseases. METHODS: Items on coping were extracted from qualitative interviews with patients which were supplemented by items from a literature review. A systematic multi-stage process of item refinement was carried out followed by expert panel discussion and cognitive interviews...
May 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29728753/heredity-and-in-vivo-confocal-microscopy-of-punctiform-and-polychromatic-pre-descemet-dystrophy
#11
María Angélica Henríquez Recine, Kelly Sonia Marquina Lima, Elena Vallespín García, Sixto García-Miñaur, José Manuel Benitez Del Castillo, Ana Boto de Los Bueis
PURPOSE: To describe and analyze the biomicroscopic features and in vivo confocal microscopy of the crystalline form of pre-Descemet corneal dystrophy (PDCD). METHODS: We examined two non-related families using biomicroscopy, in vivo confocal microscopy, and a genetic study using a gene panel test, looking for mutations in the PIKFYVE gene. RESULTS: A slit-lamp examination of the first family revealed polychromatic crystalline punctiform opacities distributed all over the stroma in 8 of 11 family members in three generations with an autosomal dominant inheritance...
May 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29725825/lamellar-macular-holes-in-the-eyes-with-pathological-myopia
#12
Roberto dell'Omo, Gianni Virgili, Ferdinando Bottoni, Barbara Parolini, Serena De Turris, Attilo Di Salvatore, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To study the natural history and morphologic characteristics of lamellar macular holes (LMHs) in the eyes with pathological myopia. METHODS: Retrospective observational case series of 44 eyes of 44 patients examined at a single institutional vitreoretinal practice. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue fundus autofluorescence (B-FAF) to be included...
May 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29721663/combined-vegf-pdgf-inhibition-using-axitinib-induces-%C3%AE-sma-expression-and-a-pro-fibrotic-phenotype-in-human-pericytes
#13
Jakob Siedlecki, Ben Asani, Christian Wertheimer, Anna Hillenmayer, Andreas Ohlmann, Claudia Priglinger, Siegfried Priglinger, Armin Wolf, Kirsten Eibl-Lindner
PURPOSE: Large trials on anti-VEGF/PDGF (vascular endothelial/platelet-derived growth factor) combination therapy have been established to improve management of neovascular activity in age-related macular degeneration. Targeting pericytes, PDGF is thought to induce vessel regression and reduce fibrovascular scarring. The fate of pericytes exposed to anti-VEGF/PDGF combination therapy is not clear. Therefore, this study was designed to study the influence of anti-VEGF/PDGF on pericyte phenotype and cellular behavior...
May 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29721662/outflow-enhancement-by-three-different-ab-interno-trabeculectomy-procedures-in-a-porcine-anterior-segment-model
#14
Yalong Dang, Chao Wang, Priyal Shah, Susannah Waxman, Ralitsa T Loewen, Ying Hong, Hamed Esfandiari, Nils A Loewen
PURPOSE: To evaluate three different microincisional ab interno trabeculectomy procedures in a porcine eye perfusion model. METHODS: In perfused porcine anterior segments, 90° of trabecular meshwork (TM) was ablated using the Trabectome (T; n = 8), Goniotome (G; n = 8), or Kahook device (K; n = 8). After 24 h, additional 90° of TM was removed. Intraocular pressure (IOP) and outflow facility were measured at 5 and 10 μl/min perfusion to simulate an elevated IOP...
May 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29713817/23g-pars-plana-vitrectomy-for-vitreal-floaters-prospective-assessment-of-subjective-self-reported-visual-impairment-and-surgery-related-risks-during-the-course-of-treatment
#15
Ursula Hahn, Frank Krummenauer, Klaus Ludwig
PURPOSE: Quantifying the subjective impairment due to floaters based on an indication-specific questionnaire and setting its change between prior to and 3/12 months after elective vitrectomy in relation to surgical risks. METHODS: Single-arm longitudinal observational multicenter study. Sixty-four floater patients underwent 23G pars plana vitrectomy; simultaneous phacoemulsification was excluded. An overall self-rated impairment index (SRI) and sub-indices SRI were calculated on the basis of a modified Visual Quality of Life questionnaire (VQoL), which addresses general vision, glare, near-sight problems and mobility of floaters...
April 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29713816/comparison-between-wide-angle-oct-angiography-and-ultra-wide-field-fluorescein-angiography-for-detecting-non-perfusion-areas-and-retinal-neovascularization-in-eyes-with-diabetic-retinopathy
#16
Osamu Sawada, Yusuke Ichiyama, Syunpei Obata, Yuka Ito, Masashi Kakinoki, Tomoko Sawada, Yoshitsugu Saishin, Masahito Ohji
PURPOSE: To compare the ability of wide-angle optical coherence tomography angiography (OCTA) with that of ultra-wide field fluorescein angiography (UWFFA) to detect non-perfusion areas (NPAs) or retinal neovascularization (NV) in eyes with diabetic retinopathy (DR). METHODS: Patients with DR underwent UWFFA using the Optos® panoramic 200Tx imaging system and wide-angle OCTA with 12 × 12 mm fields of five visual fixations using the PLEX Elite 9000®. We compared the abilities of UWFFA and OCTA to detect NPAs and NV...
April 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29707735/clinical-analysis-of-90-cases-of-malignant-lacrimal-sac-tumor
#17
Xinmao Song, Jie Wang, Shengzi Wang, Weifang Wang, Shuyi Wang, Wenjia Zhu
PURPOSE: To investigate the pathology, clinical manifestations, and potential risk factors associated with the prognosis of malignant lacrimal sac tumors. In addition, the treatment outcomes and complications were also evaluated. METHODS: Ninety cases of malignant lacrimal sac tumors were retrospectively analyzed at our hospital. Pathological classifications, clinical manifestations, risk factors, and follow-up time were documented. The outcomes and complications were evaluated and compared among the various treatment modalities...
April 29, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29705838/potential-predictors-for-frequent-relapse-in-human-leukocyte-antigen-b27-associated-uveitis
#18
Mirinae Kim, Yoon Seob Sim, Seung Yong Choi, Young-Hoon Park
PURPOSE: To identify potential predictors for frequent relapse in a cohort of patients with human leukocyte antigen (HLA)-B27-associated uveitis in a tertiary referral center at the initial visit. METHODS: This retrospective cohort study comprised 130 patients diagnosed with HLA-B27-associated uveitis. Subjects were divided into two groups according to the frequency of uveitis attacks (number/year): frequent relapse (FR) (who relapsed more than twice a year, 38) and infrequent relapse (IR) group (who relapsed twice or less than twice a year, 92)...
April 29, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29705837/outcome-of-optical-iridectomy-in-peters-anomaly
#19
Oriel Spierer, Kara M Cavuoto, Sirinya Suwannaraj, Craig A McKeown, Ta Chen Chang
PURPOSE: Optical iridectomy creates a defect in the iris to allow an alternative clear visual axis in cases of central corneal opacities occluding the pupillary axis. The purpose of this study is to evaluate the outcomes of optical sector iridectomy in children with Peters anomaly. METHODS: Retrospective case series. The medical records of all patients diagnosed with Peters anomaly who underwent optical iridectomy during the years 2002-2014 were reviewed. Data collection included surgical and visual acuity outcomes...
April 28, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29704064/the-legacy-of-jules-gonin-one-hundred-years-of-identifying-and-treating-retinal-breaks
#20
EDITORIAL
Stephen G Schwartz, Robert Garoon, William E Smiddy, Harry W Flynn
No abstract text is available yet for this article.
April 28, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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