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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28711991/one-year-efficacy-of-adjunctive-use-of-ripasudil-a-rho-kinase-inhibitor-in-patients-with-glaucoma-inadequately-controlled-with-maximum-medical-therapy
#1
Hiroshi Inazaki, Satoshi Kobayashi, Yoko Anzai, Hisayoshi Satoh, Shimpei Sato, Maiko Inoue, Shin Yamane, Kazuaki Kadonosono
PURPOSE: The aim of this study was to evaluate the one-year efficacy, ability to lower intraocular pressure, and tolerability of ripasudil, a rho-kinase inhibitor, in patients with glaucoma inadequately controlled with maximum medical therapy. METHODS: This prospective, non-comparative, interventional case-series study included 39 patients with primary open-angle glaucoma inadequately controlled with maximum medical therapy before treatment with ripasudil. Ripasudil was administered twice per day as adjunctive therapy to ongoing glaucoma treatment...
July 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28710518/encouraging-results-of-25g-minimally-invasive-vitrectomy-surgery-for-diabetic-tractional-retinal-detachment-reply
#2
LETTER
Mikel Mikhail, Andre Ali-Ridha, Sarah Chorfi, Michael A Kapusta
No abstract text is available yet for this article.
July 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28702697/the-acute-effect-of-strength-exercises-at-different-intensities-on-intraocular-pressure
#3
Jesús Vera, Amador García-Ramos, Raimundo Jiménez, David Cárdenas
BACKGROUND: This study aimed to determine the effect of two basic strength exercises with progressive loads on intraocular pressure (IOP). METHODS: Seventeen (out of 20 recruited) physically active male military officers (46 ± 4.77 years) performed the jump squat and the ballistic bench press exercises, in counterbalanced order, with four and five progressive loads, respectively. IOP was measured with a rebound tonometer before and after each of the corresponding loads...
July 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28702696/mapping-diurnal-changes-in-choroidal-haller-s-and-sattler-s-layer-thickness-using-3-dimensional-1060-nm-optical-coherence-tomography
#4
Maximilian Gabriel, Marieh Esmaeelpour, Farnusch Shams-Mafi, Boris Hermann, Behrooz Zabihian, Wolfgang Drexler, Susanne Binder, Siamak Ansari-Shahrezaei
PURPOSE: To test the significance of diurnal changes in choroidal, Haller's and Sattler's layer thickness in healthy subjects using spatial analysis of three-dimensional (3D) 1060-nm optical coherence tomography (OCT) scans. METHODS: Automatically generated choroidal, Haller's and Sattler's layer thickness maps were statistically analyzed for 19 healthy subjects at two time points (8 a.m. and 6 p.m.) that represent the currently proposed ChT peak and nadir. All subjects were imaged by high-speed 1060-nm OCT over a 36° × 36° field of view...
July 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28689223/author-response-oct-angiography-in-idiopathic-macular-hole-some-methodological-concerns
#5
LETTER
Yufei Teng, Wu Liu
No abstract text is available yet for this article.
July 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28689222/insights-into-autofluorescence-patterns-in-stargardt-macular-dystrophy-using-ultra-wide-field-imaging
#6
Vinod Kumar
PURPOSE: To characterize autofluorescence (AF) patterns occurring in Stargardt macular dystrophy (STGD1) using ultra-wide-field (UWF) imaging. METHODS: This paper is a cross-sectional observational study of 22 eyes of 11 patients (mean age 23.44 years) with Stargardt disease-fundus flavimaculatus who presented with decrease of vision at a tertiary eye care center. UWF short-wave AF images were obtained from all the patients using an Optos TX200 instrument. The main outcome measures were to assess patterns of AF changes seen on UWF AF imaging...
July 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28687872/high-frequency-aflibercept-injections-in-persistent-neovascular-age-related-macular-degeneration
#7
LETTER
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
July 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28681138/ocriplasmin-treatment-for-vitreomacular-traction-in-real-life-can-the-indication-spectrum-be-expanded
#8
Kleanthis Manousaridis, Silvia Peter-Reichart, Stefan Mennel
PURPOSE: To evaluate the efficacy of intravitreal ocriplasmin for the resolution of vitreomacular traction (VMT) with or without a full thickness macular hole (FTMH) in the clinical setting and to assess whether the indication spectrum of this treatment modality can be expanded beyond that of the MIVI-TRUST trials. METHODS: The records of patients with VMT with or without FTMH, who were treated with intravitreal ocriplasmin were reviewed. Patients were divided in two groups...
July 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28674835/photodynamic-therapy-in-chronic-central-serous-chorioretinopathy-with-subretinal-fluid-outside-the-fovea
#9
Elon H C van Dijk, Greet Dijkman, Camiel J F Boon
PURPOSE: To assess the efficacy of photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC), in whom subretinal fluid (SRF) was solely present outside the foveal area. METHODS: In this retrospective study, 16 eyes of 15 cCSC patients who received half-dose PDT because of notable subjective visual complaints due to the presence of extrafoveal SRF, were included. An ophthalmic examination was performed before treatment, including Early Treatment Diabetic Retinopathy Study best-corrected visual acuity measurement, applanation tonometry, slit-lamp examination, and indirect ophthalmoscopy, followed by multimodal imaging, including fundus photography, fundus autofluorescence, spectral-domain optical coherence tomography (OCT), enhanced-depth imaging OCT of the choroid, fluorescein angiography, and indocyanine green angiography...
July 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28674834/intraocular-silicone-implant-to-treat-chronic-ocular-hypotony-an-in-vivo-trial
#10
Wesal Bayoudh, Dörthe Carstesen, Peter Walter, Andreas W A Weinberger
PURPOSE: The management of chronic ocular hypotony and complicated proliferative vitreoretinopathy-related retinal detachment represents a challenge. Being non-absorbable and non-biodegradable, a silicone oil implant is expected to restore the volume and the intraocular pressure of the globe, as well as to approximate the detached retina. Further advantages could be a long-term tamponade potential, absence of toxicity, and prevention of silicone oil emulsification or anterior chamber oil-prolapse...
July 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28669042/paravascular-inner-retinal-abnormalities-in-healthy-eyes
#11
Rie Osaka, Saki Manabe, Yukiko Miyoshi, Yuki Nakano, Ayana Yamashita, Chieko Shiragami, Kazuyuki Hirooka, Yuki Muraoka, Akitaka Tsujikawa
PURPOSE: To investigate the prevalence and characteristics of paravascular inner retinal abnormalities in healthy eyes. MATERIALS AND METHODS: In this prospective observational case series, we included 178 healthy eyes (178 patients) with no ocular diseases. Eyes with co-existing ocular diseases, e.g., epiretinal membrane, glaucoma, or high myopia, were excluded from the current study. The posterior pole and paravascular areas of the temporal arcade vessels were comprehensively examined by dense radial scanning of optical coherence tomography (OCT) with the extended field imaging technique...
July 2, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28669041/two-year-results-of-a-treat-and-extend-regimen-with-aflibercept-for-polypoidal-choroidal-vasculopathy
#12
Masahiro Morimoto, Hidetaka Matsumoto, Kensuke Mimura, Hideo Akiyama
PURPOSE: To evaluate the effects of aflibercept therapy using a treat-and-extend regimen on treatment-naïve polypoidal choroidal vasculopathy (PCV). METHODS: In a retrospective interventional case series of 58 eyes of 58 patients with PCV, we assessed best-corrected visual acuity (BCVA), central macular thickness (CMT), central choroidal thickness (CCT), and number of injections for 2 years. Polypoidal lesions were also evaluated before treatment and after the loading phase by indocyanine green angiography...
July 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28669040/oct-angiography-in-idiopathic-macular-holes-some-methodological-concerns
#13
LETTER
Joel Hanhart
No abstract text is available yet for this article.
July 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28669039/blockade-of-mmp-2-and-mmp-9-inhibits-corneal-lymphangiogenesis
#14
Hai-Tao Du, Ling-Ling Du, Xian-Ling Tang, Hong-Yan Ge, Ping Liu
PURPOSE: To investigate the roles of a selective MMP-2 and -9 inhibitor (SB-3CT) in corneal inflammatory lymphangiogenesis. METHODS: The expression of MMP-2 and -9 in the cornea after suture inplacement, treated with SB-3CT or negative control, was detected by real-time polymerase chain reaction (PCR). Inflammatory corneal neovascularization (NV) was induced by corneal suture placement. Mice were treated with SB-3CT eye drops (twice daily for 1 week, 5 μL per drop; 50, 100, or 200 μM)...
July 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28687871/chromatic-pupillography-in-hemianopia-patients-with-homonymous-visual-field-defects
#15
Fumiatsu Maeda, Carina Kelbsch, Torsten Straßer, Karolína Skorkovská, Tobias Peters, Barbara Wilhelm, Helmut Wilhelm
PURPOSE: The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways...
June 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28667484/encouraging-results-of-25g-minimally-invasive-vitrectomy-surgery-for-diabetic-tractional-retinal-detachment
#16
LETTER
Koushik Tripathy
No abstract text is available yet for this article.
June 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28667483/is-ellipsoid-zone-integrity-essential-for-visual-recovery-in-myopic-neovascularization-after-anti-vegf-therapy
#17
Paolo Milani, Marco Pellegrini, Amedeo Massacesi, Stefania Moschini, Marco Setaccioli, Davide Soranna, Antonella Zambon, Ferdinando Bottoni, Fulvio Bergamini
PURPOSE: To evaluate functional prognostic factors and neuroretinal changes after anti-vascular endothelial growth factor (VEGF) treatment in patients with naïve, recent myopic neovascularization (mCNV), as assessed by spectral-domain optical coherence tomography (SD-OCT). METHODS: Specific changes in tomographic features between baseline and final follow-up were retrospectively evaluated by two examiners independently. Imaging was obtained by a multi-modal imaging system which combines fluorescein angiography and SD-OCT...
June 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28660443/isoforms-of-tgf-%C3%AE-in-the-aqueous-humor-of-patients-with-pseudoexfoliation-syndrome-and-a-possible-association-with-the-long-term-stability-of-the-capsular-bag-after-cataract-surgery
#18
Justus G Garweg, Souska Zandi, Christin Gerhardt, Isabel B Pfister
BACKGROUND: Pseudoexfoliation syndrome (PEXS) may go along with capsular bag shrinkage and luxation. In the present study, we focus on an association of isoforms of TGF-β with capsular bag luxation. METHODS: Aqueous humor was collected intraoperatively from 20 healthy controls and from 73 otherwise healthy patients with PEXS [PEXS without complications (PEX, n = 33), late PEXS with glaucoma (PEXG, n = 30) and with IOL and capsular bag luxation (PEXL, n = 10)]...
June 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28660442/limbal-rebound-tonometry-clinical-comparisons-and-applications
#19
Georgios Bontzos, Michail Agiorgiotakis, Zoi Kapsala, Efstathios Detorakis
PURPOSE: The accuracy of contact tonometry may be compromised in cases with disorders affecting central corneal bio-mechanical properties. This study examined the reliability of rebound tonometry (RT) on the area of corneo-scleral limbus, instead of the conventional central corneal area, and the correlation of findings with ocular biometric parameters. METHODS: This is a prospective cross-sectional study performed at the Department of Ophthalmology of the University Hospital of Heraklion, in Crete, Greece...
June 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28656342/effect-of-intravitreal-ranibizumab-on-the-ocular-circulation-of-the-untreated-fellow-eye
#20
Masahiko Sugimoto, Takayasu Nunome, Rie Sakamoto, Maki Kobayashi, Mineo Kondo
PURPOSE: To evaluate the effects of unilateral intravitreal ranibizumab (IVR) on the ocular circulation of the fellow eyes. METHODS: Fifteen eyes of 15 patients with macular edema (average age 69.6 ± 11.8 years) were studied. Eleven eyes had diabetic macular edema (DME) and four eyes had macular edema associated with a branch retinal vein occlusion. Each eye received 0.5 mg of IVR. The blood circulation on the optic nerve head of the treated and untreated eyes were determined by laser speckle flowgraphy (LSFG, Softcare Co...
June 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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