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Graefe's Archive for Clinical and Experimental Ophthalmology

Efstathios Vounotrypidis, Iris Schuster, Marc J Mackert, Daniel Kook, Siegfried Priglinger, Armin Wolf
PURPOSE: To investigate preoperative ocular risk factors and indications for secondary intraocular lens (IOL) implantation and compare postoperative complications, visual and refractive outcomes in a tertiary referral center. METHODS: Patients older than 14 years that underwent secondary IOL implantation and had a minimum follow-up of 3 months were enrolled in this retrospective case series. Preoperative ocular risk factors, indications for surgery, postoperative complications, and visual and refractive outcomes including prediction error (PE) and absolute error (AE) were evaluated...
November 9, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Fahriye Groen-Hakan, Laura Eurelings, Jan van Laar, Aniki Rothova
PURPOSE: To relate erythrocyte sedimentation rates (ESR) and C-reactive protein (CRP) values to different uveitis entisties. METHODS: A retrospective study of patients with a first episode of active uveitis visiting the Erasmus University Medical Center, uveitis clinic, Rotterdam, the Netherlands, was performed. Levels of ESR and CRP were determined within 2 weeks and 1 week after onset of uveitis, respectively. Uveitis had to be of unknown origin at that moment...
November 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Yoshitsugu Matsui, Mineo Kondo, Eriko Uchiyama, Ryohei Mityata, Hisashi Matsubara
PURPOSE: A new clinical ultrahigh-resolution spectral domain optical coherence tomography (UHR-SD-OCT) system using an original averaging technique named "A-scan matching algorithm" was developed. The aim of this study was to determine whether our new UHR-SD-OCT system can obtain clearer sectional images of the retina than conventional standard resolution SD-OCT systems (SR-SD-OCT). METHODS: We recorded horizontal B-scan images of 42 normal eyes using our new UHR-SD-OCT device (Bi-μ, Kowa) and a conventional SR-SD-OCT (Spectralis, Heidelberg)...
November 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Arno Haus, Peter Szurman, Anna-Maria Seuthe
PURPOSE: To introduce the novel technique of suture probe canaloplasty with suprachoroidal drainage (SCD) as a catheter-independent and cost-saving method to perform non-penetrating glaucoma surgery. METHODS: Prospective interventional study with a 12-month follow-up. A standard 6/0 polypropylene suture is twisted in a special manner to create a double helix with a small loop at its end. Then canaloplasty with SCD is performed, but instead of using the standard canaloplasty catheter, Schlemm's canal is probed with the twisted suture...
November 7, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Emine Alyamaç Sukgen, Yusuf Koçluk
PURPOSE: To compare the results of ranibizumab and aflibercept treatment in infants with treatment-requiring retinopathy of prematurity (ROP) in the posterior zone. METHODS: In this single-center, retrospective study, the records of the infants, who were treated between January 2015 and June 2017 in a tertiary center for screening and treatment of ROP, were reviewed. Infants who were administered ranibizumab or aflibercept as initial treatment and completed at least 1 year of corrected age were included...
November 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Cheolmin Yun, Jungah Huh, So Min Ahn, Boram Lee, Jee Taek Kim, Soon-Young Hwang, Seong-Woo Kim, Jaeryung Oh
PURPOSE: The purpose of the study is to investigate the characteristics of choriocapillaris flow based on the underlying choroidal vasculature in fellow eyes with central serous chorioretinopathy (CSC). METHODS: We included 57 patients with CSC and normal controls. Characteristics of choriocapillaris flow were evaluated using swept-source optical coherence tomography (OCT) angiography. We divided the choroidal layer into the vascular and stromal beds according to the choroid vessels on en-face OCT images...
November 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Brigitte Simonsz-Tóth, Maurits V Joosse, Dorothea Besch
PURPOSE: Since neurophysiological and clinical trials have shown evidence for plasticity in the adult visual system, the upper age limit for amblyopia treatment is not rigid. The aim of this study was to investigate the efficacy of occlusion therapy and refractive adaptation in untreated amblyopic patients 12 to 40 years of age. METHODS: In a prospective study, all patients had full orthoptic and ophthalmic assessment including cycloplegic retinoscopy. Patients with a newly prescribed optical correction underwent an 18-week refractive adaptation...
November 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Niro Kasahara
No abstract text is available yet for this article.
November 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
L De Simone, L Belloni, R Aldigeri, A Zerbini, V Mastrofilippo, A Sangiovanni, M Parmeggiani, L Fontana, Luca Cimino
PURPOSE: The diagnosis of cytomegalovirus (CMV) anterior uveitis in immunocompetent patients requires confirmation by polymerase chain reaction (PCR) analysis and/or intraocular antibody index (AI) assay. In this study, we analyzed the different contributions of PCR and AI to CMV diagnosis by performing one single aqueous tap. METHODS: A retrospective chart review was conducted of HIV-negative patients attending the Ocular Immunology Unit of Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy, from March 2015 to April 2018 with a diagnosis of hypertensive anterior granulomatous uveitis compatible with suspected CMV etiology...
November 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Ouafa Sijilmassi, José Manuel López-Alonso, María Del Carmen Barrio Asensio, Aurora Del Río Sevilla
PURPOSE: Folic acid (FA) is an essential vitamin for embryonic development. It plays particularly a critical role in RNA, DNA and protein synthesis. On the other hand, the collagen IV and laminin-1 are important proteins during embryonic development. This study was done to find if FA deficiency at a short and a long term in mothers could alter the tissue texture of retina and lens of the progeny. METHODS: Collagen IV and laminin-1 were localized by immunohistochemistry in the lens and retina of the FA-deficient embryos...
November 3, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Young Choi, Sungmin Jang, Soo Youn Choi, Seung-Hyun Kim, Young-Woo Suh
PURPOSE: To investigate the extent of adhesion and changes in the Y configuration after the Y-split procedure, compared with the posterior fixation suture. METHODS: Twelve New Zealand white rabbits were included in the study. The 10-mm Y-split procedure was performed in the superior rectus muscle (SR) of one eye, and the 10-mm posterior fixation suture was made in the SR of the other eye. Six weeks after surgery, the Y arm lengths and lengths of adherence to the sclera were measured...
October 31, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Mario R Romano, Davide Allegrini, Chiara Della Guardia, Stefano Schiemer, Immacolata Baronissi, Mariantonia Ferrara, Gilda Cennamo
Diabetic macular edema (DME) is still one of the main causes of visual impairment. Repeated intravitreal injections of ranibizumab are considered the gold standard treatment, but the efficacy in patients with prominent cystic characteristics remains uncertain. In diabetic retinas, the identification of both antero-posterior and, particularly, tangential tractions is crucial to prevent misdiagnosis of tractional and refractory DME, and therefore to prevent poor treatment outcomes. The treatment of tractional DME with anti-VEGF injections could be poorly effective due to the influence of a tractional force...
October 31, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Andrea Cacciamani, Graziana Esposito, Fabio Scarinci, Mariacristina Parravano, Lucia Dinice, Marta Di Nicola, Alessandra Micera
PURPOSE: To quantify inflammatory, growth/angiogenic, and tissue remodeling mediators in vitreal reflux (VR) in patients with diabetic macular edema (DME), as collected at first and third intravitreal anti-vascular endothelial growth factor (anti-VEGF, ranibizumab) injection. METHODS: Thirty (30) consecutive patients (type-2 diabetes mellitus) with visual impairments due to DME and undergoing the first (untreated DME) or the third (treated DME) intravitreal injection of anti-VEGF were included in the study...
October 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Maurizio Battaglia Parodi, Riccardo Sacconi, Francesco Romano, Francesco Bandello
PURPOSE: To describe the hyperreflective foci (HF) characteristics in eyes affected by Stargardt disease (STGD), correlating HF with the atrophy progression at 1-year follow-up. METHODS: Prospective observational case series with 1-year follow-up. Twenty-eight eyes (14 patients) affected by STGD and 28 eyes (14 age- and sex-matched healthy patients) used as control group were recruited. All patients underwent a complete ophthalmologic examination including fundus autofluorescence and spectral-domain optical coherence tomography...
October 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Andrew Winegarner, Atsuya Miki, Miho Kumoi, Yuichiro Ishida, Taku Wakabayashi, Susumu Sakimoto, Shinichi Usui, Kenji Matsushita, Kohji Nishida
PURPOSE: To evaluate the capability of anterior segment Scheimpflug imaging for detecting primary angle closure disease (PACD): primary angle closure suspect, primary angle closure, and primary angle closure glaucoma, using cutoff points derived from reference databases of healthy subjects. METHODS: Eighty-seven patients with PACD and 49 age-matched control subjects were included. We evaluated the sensitivity and specificity of anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) to differentiate patients with PACD from controls...
October 30, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Cassia Senger, Marcelo Jordão Lopes da Silva, Carlos Gustavo De Moraes, André Messias, Jayter Silva Paula
BACKGROUND: Visual search is a critical skill for several daily tasks and may be compromised in patients with impaired vision. The objective of this study was to study the relationships between exploratory visual search performance (EVSP) visual field (VF) sensitivity in patients with glaucoma. METHODS: Primary open-angle glaucoma patients (POAG; n = 29) and healthy (Control; n = 28) individuals with best corrected visual acuity better than 0.2 logMAR underwent a comprehensive ophthalmological examination, including Humphrey VF tests (24-2 SITA-Standard), and a monocular exploratory visual search digit-based task performed using a software that quantifies the time spent to find a targert on a random array of digits distributed on nine sequential screens...
October 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Tommy C Y Chan, Kelvin H Wan, David S Y Kang, Tiffany H K Tso, George P M Cheng, Yan Wang
PURPOSE: To determine the association between anterior corneal curvature and optical zone centration as well as its impact on aberration profiles in small-incision lenticule extraction (SMILE) and laser in situ keratomileusis (LASIK). METHODS: Seventy-eight eyes of 78 patients treated with SMILE (45 eyes) and LASIK (33 eyes) were included. The centration of the optical zone was evaluated on the instantaneous curvature difference map between the preoperative and 3-month postoperative scans using a superimposed set of concentric circles...
October 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Yoav Nahum, Reut Israeli, Gabriel Mircus, Ilana Perelshtein, Miriam Ehrenberg, Shay Gutfreund, Aharon Gedanken, Irit Bahar
PURPOSE: This work examined the antibacterial and physical effects of a novel Zn-CuO nanocoating applied on a silicone hydrogel contact lens. METHODS: Zn-CuO coating of PureVision balafilcon-A soft contact lenses (Bausch&Lomb, Rochester, NY) was performed by sonochemical deposition using a high-intensity ultrasonic horn. Non-coated PureVision lenses served as a control in all experiments. Adhesion assays for P. aerueginosa and S. epidermidis to the coated lenses were performed to identify the minimal coating concentration which still possessed antibacterial activity...
October 27, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Heidrun L Deissler, Gerhard K Lang, Gabriele E Lang
PURPOSE: Intravitreal injection of the VEGF-binding protein aflibercept is widely used to treat various ocular diseases. In vitro, immortalized bovine retinal endothelial cells (iBREC) take up and transport aflibercept through the cell layer in a serum-dependent manner, likely mediated through the neonatal Fc receptor (FcRn), but degradation of the Fc domain-containing protein might be a competing intracellular process. Therefore, aflibercept's associations with proteins either involved in FcRn-mediated transport or in the lysosomal pathway were studied...
October 26, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Yen-Chih Chen, Yan-Ting Chen, San-Ni Chen
PURPOSE: To assess foveal microvascular structure and the correlation between foveal retinal thickness and best corrected visual acuity (BCVA) in children with retinopathy of prematurity (ROP). METHODS: This is a retrospective case-control study. A total 42 eyes in 23 patients with history of anti-vascular endothelial factor (VEGF) agent treatment and 51 eyes of 27 healthy age-matched subjects as the control group were analyzed. Foveal avascular zone (FAZ) and foveal vessel density (VD) were measured by optical coherence tomography angiography (OCT-A)...
October 25, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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