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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28337547/retinal-vascular-changes-after-vitrectomy-for-idiopathic-epiretinal-membrane-a-pilot-study-with-dynamic-vessel-analysis
#1
Lorenzo Iuliano, Giovanni Fogliato, Giuseppe Querques, Francesco Bandello, Marco Codenotti
PURPOSE: To investigate, using the Dynamic Vessel Analyzer (DVA), the retinal vascular changes that may occur after vitrectomy for idiopathic epiretinal membrane (ERM). METHODS: Twenty-six eyes of 13 patients affected by unilateral idiopathic ERM were prospectively analyzed. 13 fellow eyes were used as control. The static (central retinal artery and vein equivalents) and dynamic (after flicker light stimulus) DVA analysis was performed at baseline (1 day before surgery) and 6 months after vitrectomy...
March 23, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28331997/author-reply-central-corneal-thickness-determination-in-corneal-edema
#2
LETTER
D Kuerten, N Plange, P Walter, M Fuest
No abstract text is available yet for this article.
March 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28321498/astigmatic-treatment-and-small-incision-lenticule-extraction-smile
#3
LETTER
Alireza Peyman, Mohammad-Hasan Alemzadeh-Ansari
No abstract text is available yet for this article.
March 20, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28314955/outcome-of-descemet-stripping-automated-endothelial-keratoplasty-in-eyes-with-an-ahmed-glaucoma-valve
#4
Patrick J Chiam, Robert Cheeseman, Vivian W Ho, Vito Romano, Anshoo Choudhary, Mark Batterbury, Stephen B Kaye, Colin E Willoughby
PURPOSE: The purpose was to investigate the survival of Descemet stripping automated endothelial keratoplasty (DSAEK) in eyes with an Ahmed glaucoma valve (AGV). METHODS: The study had a retrospective case-series of patients with an AGV in the anterior chamber undergoing a DSAEK. Included in the analysis were graft size, number of previous operations, post-operative glaucoma medications, post-operative intraocular pressure (IOP) control, graft size and donor factors (age, endothelial cell density, and post-mortem time)...
March 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28314954/retinal-and-choroidal-vascular-features-in-patients-with-retinitis-pigmentosa-imaged-by-oct-based-microangiography
#5
Kasra A Rezaei, Qinqin Zhang, Chieh-Li Chen, Jennifer Chao, Ruikang K Wang
PURPOSE: To image vascular features of retinitis pigmentosa (RP) using optical coherence tomography angiography (OCTA). METHODS: Patients with RP were imaged by spectral domain optical coherence tomography based angiography (OCTA). The optical microangiography (OMAG) algorithm was applied to scanned datasets to generate 3D OCTA retinal angiograms, i.e., OMAG angiograms. Motion tracking was used to minimize artifacts due to eye movement, and large field of view OMAG angiograms were achieved through a montage scanning protocol...
March 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28303331/implication-of-vegf-and-aquaporin-4-mediating-m%C3%A3-ller-cell-swelling-to-diabetic-retinal-edema
#6
Teruyo Kida, Hidehiro Oku, Taeko Horie, Masanori Fukumoto, Yoshitaka Okuda, Seita Morishita, Tsunehiko Ikeda
PURPOSE: Aquaporin 4 (AQP4), a water channel protein, is known to be expressed in retinal Müller cells. The purpose of this study was to determine the effects of VEGF and AQP4 channels on the volumetric changes in Müller cells. METHODS: Retinas from diabetic rats and a cultured Müller cell line, TR-MUL5, were used in this study. Intravitreal injections of VEGF or PBS were performed on either streptozotocin (STZ)-induced diabetic or normoglycemic rats. Retinal sections were immunostained for anti-glial fibrillary acidic protein (GFAP), anti-AQP4, and anti-VEGF...
March 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28303330/ocular-trauma-score-as-prognostic-value-in-traumatic-ocular-injuries-due-to-rotating-wire-brushes
#7
Konstantine Purtskhvanidze, Florian Rüfer, Alexa Klettner, Christoph Borzikowsky, Johann Roider
PURPOSE: Rotating wire brushes are used, e.g., for rust removal. Detaching fragments can cause severe eye injuries. The purpose of this study was to investigate mechanism, severity, clinical outcome, validity of Ocular Trauma Score (OTS) and to assess the likelihood of final visual acuity. METHODS: Twenty patients with traumatic ocular injuries by rotating wire brushes were included. Location and type of injury, grade of injury according to OTS, surgical procedure, and development of visual acuity were evaluated...
March 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28299439/vitamin-b12-deficiency-evaluation-and-treatment-in-severe-dry-eye-disease-with-neuropathic-ocular-pain
#8
Serkan Ozen, Murat Atabey Ozer, Mehmet Orçun Akdemir
PURPOSE: This study aims to understand the effect of vitamin B12 deficiency on neuropathic ocular pain (NOP) and symptoms in patients with dry eye disease (DED). METHODS: Patients with severe DED (without receiving topical artificial tears treatment) and ocular pain were enrolled (n = 90). Patients with severe DED and vitamin B12 deficiency (group 1, n = 45) received parenteral vitamin B12 supplement + topical treatment (artificial tears treatment + cyclosporine), and patients with severe DED and normal serum vitamin B12 level (group 2, n = 45) received only topical treatment (artificial tears treatment + cyclosporine)...
March 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28299438/adipophilin-expression-in-primary-and-metastatic-uveal-melanoma-a-pilot-study
#9
LETTER
Miltiadis Fiorentzis, Helen Kalirai, Periklis Katopodis, Sarah E Coupland
No abstract text is available yet for this article.
March 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28299437/central-corneal-thickness-determination-in-corneal-edema
#10
LETTER
Nicola Rosa, Maddalena De Bernardo
No abstract text is available yet for this article.
March 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28285324/novel-therapeutics-for-stargardt-disease
#11
REVIEW
Louise J Lu, Ji Liu, Ron A Adelman
DESCRIPTION OF SITUATION: Stargardt disease, an inherited macular dystrophy caused by mutations in the ABCA4 gene encoding a retinal transporter protein, is the most prevalent form of macular degeneration in children. Patients with Stargardt disease develop severe vision loss within their first or second decades of life, which progresses to irreversible decreased visual acuity in almost all cases. Presently, there are no standard treatments for Stargardt disease. However, encouraging progress has been made in the development of innovative approaches to preventing vision loss in Stargardt patients...
March 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28283732/comparison-of-half-dose-photodynamic-therapy-and-689-nm-laser-treatment-in-eyes-with-chronic-central-serous-chorioretinopathy
#12
Andrea Russo, Raffaele Turano, Francesco Morescalchi, Elena Gambicorti, Anna Cancarini, Sarah Duse, Ciro Costagliola, Francesco Semeraro
PURPOSE: To compare visual and anatomical outcomes between half-dose photodynamic therapy (hd-PDT) and 689 nm laser therapy (689-LT) in chronic central serous chorioretinopathy (CSC). METHODS: Forty eyes of 40 patients with symptomatic chronic CSC were randomized in a 1:1 ratio to receive either hd-PDT or 689-LT delivering 95 J/cm(2) via an intensity application of 805 mW/cm(2) over 118 s. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography findings were compared between the two treatment groups...
March 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28280989/the-role-of-pigment-epithelial-detachment-in-amd-with-submacular-hemorrhage-treated-with-vitrectomy-and-subretinal-co-application-of-rtpa-and-anti-vegf
#13
F Treumer, S Wienand, K Purtskhvanidze, J Roider, J Hillenkamp
PURPOSE: To assess the incidence of pigment epithelial detachment (PED) in age-related macular degeneration (AMD) with submacular hemorrhage (SMH) and its response to treatment with pars plana vitrectomy (ppV), subretinal co-application of recombinant tissue plasminogen activator (rtPA) and anti-VEGF, and an intravitreal gas tamponade. METHODS: Consecutive interventional case series of 132 eyes of 129 patients with neovascular AMD with SMH. All eyes underwent ppV with subretinal co-application of rtPA and bevacizumab followed by a gas tamponade...
March 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28265755/the-effect-of-center-point-shift-on-the-measurement-of-macular-thickness-a-spectral-domain-optical-coherence-tomography-study
#14
Kyoung Nam Kim, Il Hwan Shin, Jae Yun Sung, Baek Soo Kwak, Hyung Bin Lim, Young Joon Jo, Jung Yeul Kim
PURPOSE: To evaluate the effect of spectral domain-optical coherence tomography (SD-OCT) measurement center shift on the measurement of macular thickness. METHODS: This was a prospective observational case series. A total of 60 normal eyes of 60 subjects included in the study. SD-OCT macular scanning (macular cube 512 × 128 scan) was performed twice by an experienced examiner. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) were recorded...
March 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28251353/prevalence-and-characteristics-of-pseudodrusen-subtypes-in-advanced-age-related-macular-degeneration
#15
Taiyo Shijo, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Wataru Kikushima, Naohiko Tanabe, Hiroyuki Iijima
PURPOSE: The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD). METHODS: We studied 84 eyes from 84 patients with pseudodrusen associated with advanced AMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and geographic atrophy (GA). Multiple imaging modalities, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), near-infrared reflectance, and fundus autofluorescence, were employed to diagnose pseudodrusen and its subtypes...
March 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28246894/erratum-to-role-of-oxidative-stress-in-epigenetic-modification-of-mmp-9-promoter-in-the-development-of-diabetic-retinopathy
#16
Renu A Kowluru, Yang Shan
No abstract text is available yet for this article.
February 28, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28238195/switching-therapy-from-bevacizumab-to-aflibercept-for-the-management-of-persistent-diabetic-macular-edema
#17
Bobak Bahrami, Thomas Hong, Meidong Zhu, Timothy E Schlub, Andrew Chang
PURPOSE: To evaluate the visual and anatomical outcomes following switching therapy from bevacizumab to aflibercept in patients with persistent diabetic macular edema (DME). METHODS: Patients with DME and central macular thickness (CMT) >300 μm on spectral domain optical coherence tomography (SD-OCT) despite at least 4 intravitreal bevacizumab injections in the prior 6 months were recruited for this prospective, single-armed, single centre, open-label clinical trial...
February 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28238194/evaluating-relaxed-ciliary-muscle-tone-in-presbyopic-eyes
#18
Erhan Özyol, Pelin Özyol
PURPOSE: Studies of age-related changes in ciliary muscle (CM) morphology and contractility have variously reported that CM weakens or strengthens with age. In response, the aim of this study was to evaluate relaxed CM tone in vivo in pre-presbyopic and presbyopic patients using a predictor value (PCM). METHODS: Two groups of eyes-40 eyes of 40 healthy volunteers with a mean age of 28.1 ± 5.8 years and 40 eyes of 40 healthy volunteers with a mean age of 56...
February 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28236003/oct-angiography-quantifying-choriocapillary-circulation-in-idiopathic-macular-hole-before-and-after-surgery
#19
Yufei Teng, Marco Yu, Yi Wang, Xinxin Liu, Qisheng You, Wu Liu
PURPOSE: To investigate the choriocapillary circulation in the macular area for eyes with unilateral idiopathic macular hole (IMH) before and after vitrectomy using optical coherence tomography angiography (OCTA). METHODS: A prospective study of 25 patients with unilateral IMH who underwent vitrectomy and 30 age- and sex-matched healthy controls were recruited. Choriocapillary circulation was measured by OCTA to obtain two measurements: flow area and parafovea vessel density...
February 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28236002/functional-visual-acuity-in-patients-with-successfully-treated-amblyopia-a-pilot-study
#20
Sujin Hoshi, Takahiro Hiraoka, Junko Kotsuka, Yumiko Sato, Shinya Izumida, Atsuko Kato, Yuta Ueno, Shinichi Fukuda, Tetsuro Oshika
PURPOSE: The aim of this study was to use conventional visual acuity measurements to quantify the functional visual acuity (FVA) in eyes with successfully treated amblyopia, and to compare the findings with those for contralateral normal eyes. METHODS: Nineteen patients (7 boys, 12 girls; age 7.5 ± 2.2 years) with successfully treated unilateral amblyopia and the same conventional decimal visual acuity in both eyes (better than 1.0) were enrolled. FVA, the visual maintenance ratio (VMR), maximum and minimum visual acuity, and the average response time were recorded for both eyes of all patients using an FVA measurement system...
February 24, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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