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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28819823/inner-nuclear-layer-cystoid-spaces-are-a-poor-prognostic-factor-in-typical-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#1
Eui Chun Kang, Seonghee Choi, Hyoung Jun Koh
PURPOSE: To investigate predictive factors for changes in best-corrected visual acuity (BCVA) at 24 months after intravitreal ranibizumab (IVR) for neovascular age-related macular degeneration (nAMD). METHODS: This retrospective study included 55 eyes of 55 consecutive patients (32 men and 23 women) with nAMD who received three consecutive monthly IVR injections and were re-treated as needed over a 24-month period. We used the mean changes in logarithm of the minimal angle of resolution (logMAR) BCVA at 24 months as the dependent variable in regression analysis...
August 17, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28815298/the-interaction-of-pupil-response-with-the-vergence-system
#2
Moritz Feil, Barbara Moser, Mathias Abegg
PURPOSE: A gaze shift from a target at distance to a target at near leads to pupillary constriction. The regulation of this pupillary near response is ill known. We investigated the impact of accommodation, convergence, and proximity on the pupillary diameter. METHODS: We recorded pupil size and vergence eye movements with the use of an infrared eye tracker. We determined the pupillary response in four conditions: (1) after a gaze shift from far to near without accommodation, (2) after a gaze shift from far to near with neither accommodation nor convergence, (3) after accommodation alone, and (4) after accommodation with convergence without a gaze shift to near...
August 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28808786/inhibition-of-tlr4-alleviates-the-inflammation-and-apoptosis-of-retinal-ganglion-cells-in-high-glucose
#3
Lili Hu, Hongxia Yang, Ming Ai, Shuanghong Jiang
PURPOSE: To investigate the expression profiles of Toll-like receptor 4 (TLR4), the effect of TLR4 on inflammation, and apoptosis of retinal ganglion cells (RGCs) cultured in high glucose and the underlying mechanism. METHODS: A high-glucose model was established in RGCs isolated from Sprague-Dawley (SD) rats (2-3 days old) and identified with Brn3a. Primary cultured RGCs were divided into control (0 mM), HG1 (10 mM glucose), HG2 (20 mM glucose), HG3 (30 mM glucose), HG (20 mM glucose) + TAK-242 (1...
August 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28803326/short-term-results-of-endovascular-surgery-with-tissue-plasminogen-activator-injection-for-central-retinal-vein-occlusion
#4
Masaaki Ishida, Shinya Abe, Takuya Nakagawa, Atsushi Hayashi
PURPOSE: To examine the effects of retinal endovascular surgery (REVS) with tissue plasminogen activator injection into the retinal vein in central retinal vein occlusion (CRVO) eyes. METHODS: Sixteen consecutive CRVO patients with macular edema and decreased visual acuity who were referred to Toyama University Hospital between March 2014 and February 2016 were included in this study. Changes in visual acuity (VA) and central retinal thickness (CRT) were evaluated up to 6 months after REVS...
August 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28801709/dex-implant-intravitreal-injection-sustained-intraocular-hypertension-and-steroid-induced-glaucoma-in-patients-with-no-risk-factors
#5
LETTER
Rezkallah Amina, Kodjikian Laurent, Malclès Ariane, Dot Corinne
No abstract text is available yet for this article.
August 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28801699/use-of-subconjunctival-injections-of-5-fluorouracil-to-rescue-and-prolong-intraocular-pressure-reduction-for-a-failing-ahmed-glaucoma-implant
#6
LETTER
Kevin Kaplowitz, James C Tsai
No abstract text is available yet for this article.
August 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28798980/two-year-outcome-of-an-observe-and-plan-regimen-for-neovascular-age-related-macular-degeneration-treated-with-aflibercept
#7
Parmis Parvin, Marta Zola, Ali Dirani, Aude Ambresin, Irmela Mantel
PURPOSE: The purpose of our study was to investigate the two-year outcome of Aflibercept treatment for neovascular age-related macular degeneration (nAMD), using the Observe-and-Plan regimen, an individually planned treatment regimen, based on the predictability of an individual's need for retreatment, aiming to reduce the clinical burden. METHODS: Our prospective study used the Observe-and-Plan regimen with Aflibercept to treat nAMD: Three loading doses, followed by monthly observation visits until the disease-recurrence interval was determined, which then was shortened by 2 weeks in a treatment plan for the next three injections without intermediate monitoring visits...
August 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28795228/subconjunctival-injections-of-5-fluorouracil-for-failing-ahmed-glaucoma-implants
#8
LETTER
Luciano Quaranta, Andreas Katsanos, Lorenzo Legramandi, Ivano Riva
No abstract text is available yet for this article.
August 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28791546/quantitative-analysis-of-photoreceptor-layer-reflectivity-on-en-face-optical-coherence-tomography-as-an-estimator-of-cone-density
#9
Maher Saleh, Mathieu Flores, Anne Sophie Gauthier, Emeric Elphege, Bernard Delbosc
BACKGROUND: To investigate whether outer retinal reflectivity on en-face Optical coherence tomography (OCT) can be considered as an estimator of cone density measured in the same area. METHODS: Forty-one points of comparisons were studied in 9 eyes (n = 6 patients) presenting maculopathies with various degrees of impairment of the photoreceptor layer. The inner segment ellipsoid zone (EZ), interdigitation zone (IZ), and retinal pigment epithelium (RPE) reflectivity were measured on coronal reconstruction of the photoreceptor layer using homemade dedicated software (Matlab, MathWorks Inc...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28791491/retinal-vegf-levels-correlate-with-ocular-circulation-measured-by-a-laser-speckle-micro-system-in-an-oxygen-induced-retinopathy-rat-model
#10
Tadashi Matsumoto, Yuta Saito, Takashi Itokawa, Tomoaki Shiba, Mari S Oba, Haruo Takahashi, Yuichi Hori
PURPOSE: We used a Laser speckle flowgraphy (LSFG)-micro system to examine the relationship between ocular blood flow and retinal vascular endothelial growth factor (VEGF) at retinopathy onset in oxygen-induced ischemic retinopathy (OIR) model rats. METHODS: Sixteen 50/10 OIR rats were compared with 17 control rats reared in room air. In postnatal day 14 (P14) and P18 rats, we measured and analyzed the left eye's mean blur rate (MBR) by setting a rubber band on the optic nerve head center, using the LSFG-Micro...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28791473/59-eyes-with-endogenous-endophthalmitis-causes-outcomes-and-mortality-in-a-danish-population-between-2000-and-2016
#11
Søren Solborg Bjerrum, Morten la Cour
BACKGROUND: To study the epidemiology of patients with endogenous endophthalmitis in Denmark. MATERIAL AND METHODS: Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016. RESULTS: The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28786025/clinical-effects-of-3-d-printing-assisted-personalized-reconstructive-surgery-for-blowout-orbital-fractures
#12
Bin Fan, Han Chen, Ying-Jian Sun, Bei-Fen Wang, Lin Che, Shu-Yan Liu, Guang-Yu Li
PURPOSE: One of the key challenges during orbital fracture reconstructive surgery, due to the complex anatomy of the orbit, is shaping and trimming the precise contour of the implants. The objectives of this study were to describe and evaluate the use of a three-dimensional (3-D) printing technique for personalized reconstructive surgery for repairing orbital fractures. METHODS: A total of 29 cases which had 3-D technique-assisted surgical reconstruction, and 27 cases which had traditional surgery, were retrospectively analyzed...
August 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28786024/evaluation-of-optic-nerve-head-blood-flow-in-normal-rats-and-a-rodent-model-of-non-arteritic-ischemic-optic-neuropathy-using-laser-speckle-flowgraphy
#13
Hidaka Takako, Chuman Hideki, Nao-I Nobuhisa
PURPOSE: To evaluate optic nerve head (ONH) blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy (rNAION) in vivo using laser speckle flowgraphy (LSFG). METHODS: Rats were under general anesthesia; to induce NAION, Rose Bengal (RB) was injected into the tail vein. After the administration of RB, the left ONH was photoactivated using an argon green laser. We measured ONH blood flow in the normal rats and the rNAION group (at 1, 3, 7, 14, and 28 days after the induction of NAION) using an LSFG-Micro...
August 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28782074/a-cell-culture-technique-for-human-epiretinal-membranes-to-describe-cell-behavior-and-membrane-contraction-in-vitro
#14
Christian Wertheimer, Kirsten H Eibl-Lindner, Denise Compera, Alexander Kueres, Armin Wolf, Denitsa Docheva, Siegfried G Priglinger, Claudia Priglinger, Ricarda G Schumann
PURPOSE: To introduce a human cell culture technique for investigating in-vitro behavior of primary epiretinal cells and membrane contraction of fibrocellular tissue surgically removed from eyes with idiopathic macular pucker. METHODS: Human epiretinal membranes were harvested from ten eyes with idiopathic macular pucker during standard vitrectomy. Specimens were fixed on cell culture plastic using small entomological pins to apply horizontal stress to the tissue, and then transferred to standard cell culture conditions...
August 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28782073/predictors-of-treatment-warranted-retinopathy-of-prematurity-in-the-sundrop-cohort-influence-of-photographic-features
#15
Cassie A Ludwig, Margaret A Greven, Darius M Moshfeghi
PURPOSE: The Stanford University Network for the Diagnosis of Retinopathy of Prematurity (SUNDROP) initiative-an ongoing telemedicine-based initiative for in-hospital screening of high-risk infants for treatment-warranted ROP (TW-ROP)-has been shown to be a safe, reliable, and cost-effective supplement to the efforts of ROP specialists. We utilized data collected in the SUNDROP initiative to determine demographic (birth weight, sex, multiplicity), weight gain, and ocular imaging (media haze, peripapillary atrophy, fundus pigmentation) predictors of TW-ROP...
August 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28780686/high-frequency-aflibercept-injections-in-persistent-neovascular-age-related-macular-degeneration
#16
LETTER
Ilkay Kilic Muftuoglu, William R Freeman
No abstract text is available yet for this article.
August 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28779364/location-and-pressure-dependent-transmission-of-human-and-porcine-sclera-an-anterior-to-posterior-examination
#17
Philipp Simon Koelbl, Pia Klante, Frank Koch, Christian Lingenfelder, Jens Ulrich Werner, Christian Enders, Martin Hessling
PURPOSE: For diaphanoscopy or transscleral laser applications, the transmission of the sclera is an essential property. The study aimed to determine the pressure dependent transmission of human sclera from anterior to posterior. METHODS: Pressure dependent transmission measurements were performed by a pressure inducing setup at the range of 60-2058 kPa. The transmissions were measured within spectral range of 350-1100 nm. Specimens of human sclera were taken from corneo-scleral transplants...
August 5, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28779363/ganglion-cell-layer-segmentation-and-the-two-flash-multifocal-electroretinogram-improve-structure-function-analysis-in-early-glaucoma
#18
Livia M Brandao, Anna A Ledolter, Matthias Monhart, Andreas Schötzau, Anja M Palmowski-Wolfe
PURPOSE: To improve structure-function analysis in primary open-angle glaucoma (POAG) by including the two-global flash multifocal electroretinogram (2F-mfERG) and macular ganglion cell layer segmentation. METHODS: Twenty-five glaucoma patients (six pre-perimetric (PPG), 19 POAG) and 16 controls underwent 2F-mfERG, optical coherence tomography (OCT), and standard automated perimetry (SAP). For 2F-mfERG, the root mean square was calculated for the focal flash response at 15-45 ms (DC) and the global flash responses at 45-75 ms (IC1) and 75-105 ms (IC2)...
August 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28779362/early-visual-cortical-structural-changes-in-diabetic-patients-without-diabetic-retinopathy
#19
Fábio S Ferreira, João M S Pereira, Aldina Reis, Mafalda Sanches, João V Duarte, Leonor Gomes, Carolina Moreno, Miguel Castelo-Branco
BACKGROUND: It is known that diabetic patients have changes in cortical morphometry as compared to controls, but it remains to be clarified whether the visual cortex is a disease target, even when diabetes complications such as retinopathy are absent. Therefore, we compared type 2 diabetes patients without diabetic retinopathy with control subjects using magnetic resonance imaging to assess visual cortical changes when retinal damage is not yet present. METHODS: We performed T1-weighted imaging in 24 type 2 diabetes patients without diabetic retinopathy and 27 age- and gender-matched controls to compare gray matter changes in the occipital cortex between groups using voxel based morphometry...
August 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28776095/treatment-of-age-related-neovascular-macular-degeneration-the-patient-s-perspective
#20
S Müller, C Ehlken, U Bauer-Steinhusen, W Lechtenfeld, Z Hasanbasic, H Agostini, T Wilke
OBJECTIVES: The aim of this study was to assess patients' views and expectations with regard to neovascular age-related macular degeneration (nAMD) and intravitreal anti-VEGF therapy (IVT). METHODS: We conducted a multicenter, non-interventional, prospective cohort study including nAMD patients treated with IVT in Germany. Patients with at least one IVT before study enrollment and aged ≥50 years were included. Three telephone interviews were conducted during a 12-month observational period...
August 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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