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Graefe's Archive for Clinical and Experimental Ophthalmology

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https://www.readbyqxmd.com/read/28631245/hypoxia-and-inflammation-in-the-release-of-vegf-and-interleukins-from-human-retinal-pigment-epithelial-cells
#1
Olli Arjamaa, Vesa Aaltonen, Niina Piippo, Tamás Csont, Goran Petrovski, Kai Kaarniranta, Anu Kauppinen
PURPOSE: Retinal diseases are closely associated with both decreased oxygenation and increased inflammation. It is not known if hypoxia-induced vascular endothelial growth factor (VEGF) expression in the retina itself evokes inflammation, or whether inflammation is a prerequisite for the development of neovascularization. METHODS: Human ARPE-19 cell line and primary human retinal pigment epithelium (RPE) cells were used. ARPE-19 cells were kept either under normoxic (24 h or 48 h) or hypoxic conditions (1% O2, 24 h)...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28631244/optical-coherence-tomography-angiography-in-pre-perimetric-open-angle-glaucoma
#2
Gilda Cennamo, Daniela Montorio, Nunzio Velotti, Federica Sparnelli, Michele Reibaldi, Giovanni Cennamo
PURPOSE: To evaluate the diagnostic efficacy of optical coherence tomography (OCT) angiography, in patients with pre-perimetric open-angle glaucoma. METHODS: Thirty-eight consecutive eyes of 26 patients with pre-perimetric open-angle glaucoma and 48 normal eyes of 32 controls were included in this prospective study. We evaluated OCT angiography, spectral-domain OCT and visual fields parameters. Differences between controls and patients and between OCT angiography parameters and traditional glaucoma measurements were evaluated...
June 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28623400/a-novel-eyelid-motion-monitor
#3
Adi Hanuka, Maor Itzhak, Alon Berger, Mony Orbach, Eli Shoshan, Levi Schächter, Daniel Briscoe
BACKGROUND: Eyelid motion analysis can provide important information about ophthalmic, neurologic, and systemic diseases. Routine assessment of eyelid function is currently based mainly on clinical examination estimating Levator Function and static palpebral fissure measurements. Most clinical tools developed to date are cumbersome expensive and difficult to operate. Currently there is no widely available, affordable device providing user friendly precision based evaluation of eyelid kinematics...
June 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28620704/ranibizumab-versus-dexamethasone-implant-for-central-retinal-vein-occlusion-the-ranidex-study
#4
Irini Chatziralli, George Theodossiadis, Stamatina A Kabanarou, Efstratios Parikakis, Tina Xirou, Panagiotis Mitropoulos, Panagiotis Theodossiadis
PURPOSE: To compare intravitreal ranibizumab and dexamethasone implant in patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO). METHODS: Participants were 42 treatment naive patients with ME due to CRVO, who received either intravitreal 0.5 mg ranibizumab (n = 25) or intravitreal 0.7 mg dexamethasone implant (n = 17). The main outcomes included the mean change in best corrected visual acuity (BCVA) and central subfield thickness (CST) at month 12 compared to baseline in the two groups...
June 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28616716/retinal-microstructures-are-altered-in-patients-with-idiopathic-infantile-nystagmus
#5
Jinu Han, Taekjune Lee, Jong Bok Lee, Sueng-Han Han
PURPOSE: To compare segmented retinal layer thicknesses between patients with idiopathic infantile nystagmus (IIN) and controls. METHODS: This retrospective case-control study included 66 patients with IIN and 66 age-matched controls. The retinal layers were examined using spectral domain optical coherence tomography with autosegmentation. Central foveal thickness (CFT), outer nuclear layer (ONL), and outer segment length (OSL) thickness were measured at the fovea center...
June 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28616715/effects-of-intravitreal-injection-of-bevacizumab-with-or-without-anterior-chamber-paracentesis-on-intraocular-pressure-and-peripapillary-retinal-nerve-fiber-layer-thickness-a-prospective-study
#6
Masoud Soheilian, Saeed Karimi, Talieh Montahae, Homayoun Nikkhah, Seyed Aliasghar Mosavi
PURPOSE: To investigate the effects of intravitreal injection of bevacizumab (IVB) with or without anterior chamber paracentesis on intraocular pressure (IOP) and peripapillary retinal nerve fiber layer (PRNFL) thickness. METHODS: In this prospective randomized clinical trial, 90 eyes with center involving diabetic macular edema or wet type age-related macular degeneration (AMD) were randomly assigned to receive IVB either without (group A) or with (group B) anterior chamber paracentesis...
June 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28616714/effect-of-fluid-air-exchange-on-reducing-residual-silicone-oil-after-silicone-oil-removal
#7
Hideki Shiihara, Taiji Sakamoto, Hiroto Terasaki, Takehiro Yamashita, Naoya Yoshihara, Fumiki Okamoto, Nahoko Ogata, Toshifumi Yamashita, Shozo Sonoda, Yoshinori Mitamura
PURPOSE: Our purpose was to determine the effect of fluid-air exchange on the amount of silicone oil (SO) droplets remaining in the vitreous cavity after removal of the main body of the SO. METHODS: This was a retrospective comparative study of 56 eyes of 56 patients that had undergone vitrectomy with SO tamponade. Fluid-air exchange was performed during surgery in 30 eyes [Air Ex(+) group] and was not done in 26 eyes [Air Ex(-) group]. All of the eyes were examined by ultrasonography, and the images were converted to binarized image...
June 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28608272/ctg18-1-repeat-expansion-may-reduce-tcf4-gene-expression-in-corneal-endothelial-cells-of-german-patients-with-fuchs-dystrophy
#8
Sabine Foja, Mirjam Luther, Katrin Hoffmann, Andreas Rupprecht, Claudia Gruenauer-Kloevekorn
PURPOSE: It was the aim of this investigation to elucidate the functional effects of CTG18.1 trinucleotide repeat expansion and the polymorphism rs613872 in the transcription factor 4 (TCF4) in corneas of patients affected by Fuchs' endothelial corneal dystrophy (FECD). METHODS: Sixty-one unrelated German patients with FECD and 113 unaffected controls were investigated and genotyped for the CTG18.1 locus by triplet primed PCR (TP-PCR) and the rs613872 polymorphism via Sanger sequencing and by employing genomic DNA from peripheral blood leucocytes...
June 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28608271/repeated-subretinal-surgery-and-removal-of-subretinal-decalin-is-well-tolerated-evidence-from-a-porcine-model
#9
Nina Buus Sørensen, Kristian Klemp, Troels Wesenberg Kjær, Steffen Heegaard, Morten la Cour, Jens Folke Kiilgaard
PURPOSE: Subretinal perfluorocarbon liquid (PFCL) is a serious complication that can occur after retinal detachment repair. It is possible to remove the PFCL surgically, but retinal damage related to the procedure is unknown. Also, increasing interest in subretinal treatment makes it relevant to examine the functional and morphological consequences of repeated subretinal manipulation. We hypothesized that PFCL in a porcine model can be injected in the subretinal space and removed with minimal effect on retinal structure and function...
June 12, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28601912/effects-of-photodynamic-therapy-plus-intravitreal-aflibercept-with-subtenon-triamcinolone-injections-for-aflibercept-resistant-polypoidal-choroidal-vasculopathy
#10
Tsutomu Sakai, Noriko Kato, Masaomi Kubota, Hiroshi Tsuneoka
PURPOSE: To evaluate the outcome of triple therapy of photodynamic therapy combined with injections of intravitreal aflibercept (IVA) and subtenon triamcinolone acetonide for polypoidal choroidal vasculopathy (PCV) resistant to IVA. METHODS: A retrospective chart review at a single institution was conducted to identify patients with PCV resistant to treatment with IVA who were switched to treatment with triple therapy. In total, 13 eyes from 13 patients were included in the study...
June 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28601911/repeatability-of-ganglion-cell-inner-plexiform-layer-thickness-measurements-using-spectral-domain-oct-in-branch-retinal-vein-occlusion
#11
Yeon Hee Lee, Min-Su Kim, Seung Il Ahn, Hye Jin Park, Kyung Sup Shin, Jung-Yeul Kim
PURPOSE: To analyze the repeatability of thickness measurements of the central macula, ganglion cell-inner plexiform layer (GC-IPL), and retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) before and after treatment of macular edema in branch retinal vein occlusion (BRVO). METHODS: We analyzed patients with BRVO who visited our retinal clinic. The repeatability of the thickness measurements were compared using the intraclass correlation coefficient (ICC) and coefficient of variation (COV) of affected versus normal fellow eyes...
June 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28601910/the-clinical-outcomes-of-surgical-management-of-anterior-chamber-migration-of-a-dexamethasone-implant-ozurdex%C3%A2
#12
Hyunseung Kang, Min Woo Lee, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
PURPOSE: Our purpose was to describe the clinical course, and individualized management approaches, of patients with migration of a dexamethasone implant into the anterior chamber. METHODS: This was a retrospective review of four patients with seven episodes of anterior chamber migration of a dexamethasone implant. RESULTS: After 924 intravitreal dexamethasone injections, anterior migration of the implant occurred in four eyes of four patients (0...
June 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28601909/study-of-conjunctival-flora-in-anophthalmic-patients-influence-on-the-comfort-of-the-socket
#13
Alvaro Toribio, Teresa Marrodán, Isabel Fernández-Natal, Honorina Martínez-Blanco, Leandro Rodríguez-Aparicio, Miguel Á Ferrero
PURPOSE: To investigate the relationship between conjunctival flora and comfort of the socket in anophthalmic patients. METHODS: A cross-sectional clinical study including 60 patients with unilateral anophthalmia who wear a prosthetic eye. From each patient three microbiological samples were taken from the lower conjunctival sac (healthy eye, pre-prosthesis, and retro-prosthesis space of socket). The 180 samples obtained were cultured. Samples from a randomized subgroup of 29 patients were measured by spectrophotometry at 540 nm after 48 h of growth, to determine their microbial density (MD)...
June 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28600710/the-influence-of-systemic-renin-angiotensin-inhibition-on-ocular-cytokines-related-to-proliferative-vitreoretinopathy
#14
Robert Hoerster, Sascha Fauser, Claus Cursiefen, Bernd Kirchhof, Ludwig M Heindl
PURPOSE: The renin-angiotensin system is involved in the pathogenesis of fibrosis in several organs via induction of transforming growth factor (TGF) beta. In the pathogenesis of proliferative vitreoretinopathy (PVR) TGF-beta plays a pivotal role, promoting transition of retinal pigment epithelial (RPE) cells into myofibroblasts. We studied the influence of angiotensin converting enzyme-inhibition (ACEI) on cytokines and growth factors, related to PVR in aqueous humor. METHODS: We performed a post hoc analysis of a prospectively conducted interventional case series...
June 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28597076/juxtapapillary-and-circumpapillary-choroidal-melanoma-globe-sparing-treatment-outcomes-with-iodine-125-notched-plaque-brachytherapy
#15
John V Hegde, Tara A McCannel, Colin A McCannel, James Lamb, Pin-Chieh Wang, Darlene Veruttipong, Robert Almanzor, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Managing juxtapapillary and circumpapillary choroidal melanoma with brachytherapy is challenging because of technical complications with accurate plaque placement and high radiation toxicity given tumor proximity to the optic nerve. We evaluated our center's experience using ultrasound-guided, Iodine (I)-125 notched plaque brachytherapy for treating choroidal melanoma contiguous with (juxtapapillary) and at least partially surrounding the optic disc (circumpapillary). METHODS: All cases of choroidal melanoma treated with I-125 notched plaque brachytherapy at our center from September 2003-December 2013 were retrospectively reviewed...
June 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28593425/challenges-with-cataract-surgery-in-pars-planitis-patients
#16
EDITORIAL
Andrzej Grzybowski, Piotr Kanclerz, Uwe Pleyer
No abstract text is available yet for this article.
June 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28567551/mutation-analysis-of-tgfbi-and-krt12-in-a-case-of-concomitant-keratoconus-and-granular-corneal-dystrophy
#17
Xianli Du, Peng Chen, Dapeng Sun
PURPOSE: This study is to summarize the concurrent keratoconus (KC) and granular corneal dystrophy (GCD) phenotype and identify the underlying genetic cause in a 23-year-old male patient. METHODS: A detailed family history and clinical data from the patient and his parents were collected by ophthalmologic examination. The candidate genes were captured and sequenced by targeted next-generation sequencing, and the results were confirmed by Sanger sequencing. RESULTS: The proband was clinically diagnosed as a case of concurrent KC and GCD, which is a very rare presentation...
May 31, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28555418/differences-in-quality-of-life-dimensions-of-adult-strabismus-quality-of-life-and-amblyopia-strabismus-questionnaires
#18
Elizabeth S van de Graaf, Gerard J J M Borsboom, Geertje W van der Sterre, Joost Felius, Huibert J Simonsz, Henk Kelderman
PURPOSE: The Adult Strabismus Quality of Life Questionnaire (AS-20) and the Amblyopia & Strabismus Questionnaire (A&SQ) both measure health-related quality of life in strabismus patients. We evaluated to what extent these instruments cover similar domains by identifying the underlying quality-of-life factors of the combined questionnaires. METHODS: Participants were adults from a historic cohort with available orthoptic childhood data documenting strabismus and/or amblyopia...
May 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28551879/risk-of-progression-in-macula-on-rhegmatogenous-retinal-detachment
#19
Josep Callizo, Sebastian Pfeiffer, Eva Lahme, Christian van Oterendorp, Mohammed Khattab, Sebastian Bemme, Miroslav Kulanga, Hans Hoerauf, Nicolas Feltgen
PURPOSE: To identify factors that may lead to a rapid progression in macula-on rhegmatogenous retinal detachment (RRD), in particular, those that may lead to macular involvement. METHODS: Observational, prospective, single-center study. Patients referred for surgery due to primary rhegmatogenous retinal detachment with the macula on between 2009 and 2013 were included. Relevant factors analyzed included age, time delay until surgery, lens status, myopia, the detachment's location and configuration as well as number, size and type of retinal breaks...
May 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28547316/preliminary-study-of-the-safety-and-efficacy-of-medium-chain-triglycerides-for-use-as-an-intraocular-tamponading-agent-in-minipigs
#20
Vincent J Soler, Camille Laurent, Frédéric Sakr, Alain Regnier, Cyrielle Tricoire, Olivier Cases, Renata Kozyraki, Jean-Yves Douet, Véronique Pagot-Mathis
PURPOSE: To date, only silicone oils and gases have the appropriate characteristics for use in vitreo-retinal surgery as vitreous substitutes with intraocular tamponading properties. This preliminary study evaluated the safety and efficacy of medium-chain triglycerides (MCTs) for use as a tamponading agent in minipigs. METHODS: In 15 minipigs, 15 right eyes underwent vitrectomies followed by injection of MCT tamponade (day 1). Two groups were defined. In Group A (ten eyes), the surgical procedure before MCT injection included induced rhegmatogenous retinal detachment (RRD), retina flattening, and retinopexy...
May 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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