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Nuclear Medicine Communications

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https://www.readbyqxmd.com/read/29419659/validation-of-prognostic-biomarker-scores-for-predicting-progression-of-dementia-in-patients-with-amnestic-mild-cognitive-impairment
#1
Jamie Moreland, Timo Urhemaa, Mark van Gils, Jyrki Lötjönen, Jan Wolber, Christopher J Buckley
OBJECTIVE: The objective of this study was to develop and validate a practical computerized prognostic model that uses baseline psychometric and imaging data, including results of PET imaging of amyloid deposition, to predict the progression to dementia in patients at risk for Alzheimer's disease (AD). PATIENTS AND METHODS: Data from patients in a phase II trial of [F]flutemetamol for PET imaging of brain amyloid and from the Alzheimer's Disease Neuroimaging Initiative were used to train the prognostic model to yield a disease state index (DSI), a measure of the similarity of an individual patient's data to data from patients in specific diagnostic groups...
February 6, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29384832/phenotypic-appearances-of-prostate-utilizing-pet-mri-and-pet-ct-with-68ga-psma-radiolabelled-choline-and-68ga-dotatate
#2
Athar Haroon, Asim Afaq, Soujanya Nuthakki, Alex Freeman, Lorenzo Biassoni, Stefano Fanti, Mohsen Beheshti, Hikmat Jan, Sobhan Vinjamuri, Mark Emberton, Jamshed Bomanji
The objective of this study was to highlight the role of multimodality imaging and present the differential diagnosis of abnormal tracer accumulation in the prostate and periprostatic tissue. Our departments have performed molecular imaging of the prostate utilizing PET-CT and PET-MRI with a range of biomarkers including F-FDG, radiolabelled choline, Ga-DOTATATE PET-CT and Ga-PSMA images. We retrospectively reviewed the varying appearances of the prostate gland in different diseases and incidental findings in periprostatic region...
January 30, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29381586/evaluation-of-18f-fdg-pet-ct-as-a-prognostic-marker-in-advanced-biliary-tract-cancer
#3
Maria I Braghiroli, José M Mota, Paulo S Duarte, Tiago O Morita, Giovanni M Bariani, Daniela Nebuloni, Carlos A Buchpiguel, Paulo M Hoff, Rachel P Riechelmann
BACKGROUND: Advanced biliary tract cancers have a dismal prognosis. Treatment with gemcitabine plus cisplatin has resulted in a significant improvement in survival; however, early assessment of outcomes poses a challenge. OBJECTIVE: We carried out a prospective study to evaluate the prognostic role of fluorine-18 fluorodeoxyglucose (F-FDG) PET-CT scans in patients with advanced biliary tract cancer. PATIENTS AND METHODS: Patients with advanced unresectable or metastatic biliary tract cancer starting first-line chemotherapy with gemcitabine plus cisplatin underwent F-FDG PET-CT studies at baseline and after two cycles of therapy...
January 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29381585/clinico-social-factors-to-choose-radioactive-iodine-dose-in-differentiated-thyroid-cancer-patients-an-asian-survey
#4
Zeenat Jabin, Seong Young Kwon, Hee-Seung Bom, Yansong Lin, Ke Yang, Anri Inaki, Ayu Rosemeilia Dewi, Akram N Al-Ibraheem, Batool Al Balooshi, Teofilo O L San Luis
OBJECTIVE: This survey was designed to investigate the practice of radioactive iodine (RAI) therapy and clinico-social factors related to RAI dose in differentiated thyroid cancer (DTC) patients among Asian countries. MATERIALS AND METHODS: A survey questionnaire was mailed to Asian Nuclear Medicine physicians that addressed the infrastructure, general regulations on RAI therapy, adherence to recommendations, RAI dose selection, factors to elevate RAI dose, and follow-up protocols in DTC patients...
January 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29381584/oligometastatic-recurrent-prostate-cancer-detects-by-fluorine-18-choline-positron-emission-tomography-computed-tomography-in-patients-with-prostate-specific-antigen-levels-of-up-to-5%C3%A2-ng-ml
#5
Laura Evangelista, Lea Cuppari, Andrea Guttilla, Mario Gardi, Andrea Agostini, Lorenzo Ruggera, Umberto Basso, Giorgio Saladini
PURPOSE: The aim of this study was to assess the ability of fluorine-18-fluorocholine (F-FCH) PET/computed tomography (CT) to detect oligometastatic disease (OMD) in patients with early recurrence of prostate cancer (PC) [prostate-specific antigen (PSA)≤5 ng/ml]. PATIENTS AND METHODS: Between 2010 and 2016, 324 patients with PC and PSA levels of less than or equal to 5 ng/ml were recruited. The mean (SD) age of the patients was 71 (10) years. All patients were treated with a radical prostatectomy±lymphadenectomy...
January 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29381583/99mtc-trodat-1-spect-ct-imaging-as-a-complementary-biomarker-in-the-diagnosis-of-parkinsonian-syndromes
#6
Bhagwant R Mittal, Apurva Sood, Jaya Shukla, Rakhee Vatsa, Priya Bhusari, Ritu Shree, Sahil Mehta, Manoj Goyal, Manish Modi
INTRODUCTION: Parkinson's disease (PD) and Parkinson plus syndromes (PPS) are neurodegenerative movement disorders caused by loss of dopamine in the basal ganglia. The diagnosis of both PD and PPS is complex as it is made solely on the basis of clinical features, with no established imaging modality to aid in the diagnosis. Technetium-99m-labeled tropane derivative (Tc-TRODAT-1) binds to the dopamine transporters present in the presynaptic membrane of the dopaminergic nerve terminal. The aim of this prospective study was to investigate the potential usefulness of Tc-TRODAT-1 imaging in the diagnosis of PD and PPS...
January 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29360694/attenuation-correction-in-myocardial-perfusion-imaging-affects-the-assessment-of-infarct-size-in-women-with-previous-inferior-infarct
#7
Alessia Peli, Luca Camoni, Valentina Zilioli, Rexhep Durmo, Mattia Bonacina, Francesco Bertagna, Barbara Paghera, Raffaele Giubbini
BACKGROUND: Myocardial perfusion imaging is a well-established diagnostic tool in patients with known or suspected coronary artery disease. Numerous clinical trials have shown that attenuation correction (AC) in single photon emission computed tomography (SPECT) improves the diagnostic accuracy of myocardial perfusion imaging over non-AC SPECT, differentiating between scar and attenuation artifacts. We have previously shown that attenuation artifacts produce an overestimation of the size of inferior infarcts in the male population...
January 22, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29360693/the-relationship-between-semiquantitative-parameters-derived-from-technetium-99m-metoxyisobutylisonitrile-dual-phase-parathyroid-single-photon-emission-computed-tomography-images-and-disease-severity-in-primary-hyperparathyroidism
#8
Derya Çayir, Mine Araz, Ali Yalçindağ, Erman Çakal
OBJECTIVE: The relationship between multiple semiquantitative indices on technetium-99m metoxyisobutylisonitrile (Tc-99m MIBI) parathyroid single-photon emission computed tomography (SPECT) and clinical, laboratory, and radiological data was investigated in primary hyperparathyroidism. PATIENTS AND METHODS: Ninety-three patients who had a histopathologically confirmed single parathyroid adenoma (PT) were enrolled. Regions of interests were drawn around the PT, neighboring thyroid (T), and background in early and late planar images and isocontour regions of interests around the adenoma in SPECT images (PT SPECT)...
January 22, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29356758/global-scientific-productivity-in-the-field-of-pet-a-10-year-survey-of-research-activities
#9
Jixiao Lei, Xiyan Zhao, Baixuan Xu, Zhongxiang Duan, Zhihui Shen, Hui Yang, Guangli Jiao, Qiaohong Ouyang, Jiahe Tian
OBJECTIVE: The objective of this study was to assess global research output in the field of PET and to provide a general picture of PET research. MATERIALS AND METHODS: Publications on PET from 2007 to 2016 were identified using the Web of Science. The total number of papers, the number of papers adjusted by gross domestic product (GDP)/population size, total citations, and average citations were investigated. RESULTS: A total of 40 670 papers were identified in the field of PET between 2007 and 2016...
January 19, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29351124/feasibility-assessment-of-yttrium-90-liver-radioembolization-imaging-using-amplitude-based-gated-pet-ct
#10
Dustin R Osborne, Shelley N Acuff, Melissa L Neveu, Mumtaz Syed, Austin D Kaman, Yitong Fu
PURPOSE: The usage of PET/computed tomography (CT) to monitor hepatocellular carcinoma patients following yttrium-90 (Y) radioembolization has increased. Respiratory motion causes liver movement, which can be corrected using gating techniques at the expense of added noise. This work examines the use of amplitude-based gating on Y-PET/CT and its potential impact on diagnostic integrity. PATIENTS AND METHODS: Patients were imaged using PET/CT following Y radioembolization...
January 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29351123/accuracy-of-18f-naf-pet-ct-in-bone-metastasis-detection-and-its-effect-on-patient-management-in-patients-with-breast-carcinoma
#11
Wouter A M Broos, Friso M van der Zant, Maurits Wondergem, Remco J J Knol
OBJECTIVE: Determination of the accuracy of sodium fluorine-18-fluoride (F-NaF) PET/computed tomography (CT) for the evaluation of bone metastases, and the impact on patient management in breast cancer patients. PATIENTS AND METHODS: Patients with breast cancer, referred for F-NaF PET/CT between February 2014 and June 2016, were included in a database. Baseline characteristics, clinical indication, definitive diagnosis according to follow-up data, as well as changes in patient management were recorded...
January 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29346173/the-subresolution-datscan-phantom-a-cost-effective-flexible-alternative-to-traditional-phantom-technology
#12
Jonathan C Taylor, Nicholas Vennart, Ian Negus, Robin Holmes, Oliver Bandmann, Christine Lo, John Fenner
The Alderson striatal phantom is frequently used to assess I-FP-CIT (Ioflupane) image quality and to test semi-quantification software. However, its design is associated with a number of limitations, in particular: unrealistic image appearances and inflexibility. A new physical phantom approach is proposed on the basis of subresolution phantom technology. The design incorporates thin slabs of attenuating material generated through additive manufacturing, and paper sheets with radioactive ink patterns printed on their surface, created with a conventional inkjet printer...
January 17, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29315138/peptide-receptor-radionuclide-therapy-with-177lu-dota-octreotate-dosimetry-nephrotoxicity-and-the-effect-of-hematological-toxicity-on-survival
#13
Anastassia Löser, Sarah M Schwarzenböck, Martin Heuschkel, Holger S Willenberg, Bernd J Krause, Jens Kurth
OBJECTIVES: Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-DOTATATE is regarded as a safe treatment option with promising results for patients with neuroendocrine neoplasia (NEN). We aimed to study the absorbed organ and tumor doses, the renal and hematological toxicity as well as their mutual interaction. Another aim was the identification of adverse effects as possible predictors which may affect survival. METHODS: A total of 30 (14 female and 16 male) patients with inoperable/metastatic NEN were treated with 7...
January 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29309367/intratumoral-injection-of-radioactive-holmium-166-microspheres-in-recurrent-head-and-neck-squamous-cell-carcinoma-preliminary-results-of-first-use
#14
Robbert C Bakker, Robert J J van Es, Antoine J W P Rosenberg, Sebastiaan A van Nimwegen, Remco Bastiaannet, Hugo W A M de Jong, Johannes F W Nijsen, Marnix G E H Lam
BACKGROUND: Limited treatment options exist for patients with locoregional recurrences of head and neck squamous cell carcinoma (HNSCC). In the palliative setting, a single session, minimally invasive, and relatively safe therapy is desirable. This case series illustrates the feasibility of a direct intratumoral injection of radioactive holmium-166 microspheres (HoMS) in patients as a palliative treatment for recurrent HNSCC. PATIENTS AND METHODS: In this retrospective analysis, patients with already reirradiated irresectable recurrent HNSCC, for whom palliative chemotherapy was unsuccessful or impossible, were offered microbrachytherapy with HoMS...
January 5, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29300270/18f-fluorodeoxyglucose-pet-ct-and-dynamic-contrast-enhanced-mri-as-imaging-biomarkers-in-malignant-pleural-mesothelioma
#15
David O Hall, Clare E Hooper, Julie Searle, Michael Darby, Paul White, John E Harvey, Jeremy P Braybrooke, Nick A Maskell, Vidan Masani, Iain D Lyburn
PURPOSE: The purpose of this study was to compare the use of fluorine-18-fluorodeoxyglucose (F-FDG) PET with computed tomography (CT) and dynamic contrast-enhanced (DCE) MRI to predict prognosis and monitor treatment in malignant pleural mesothelioma. PATIENTS AND METHODS: F-FDG PET/CT and DCE-MRI studies carried out as part of the South West Area Mesothelioma Pemetrexed trial were used. F-FDG PET/CT and DCE-MRI studies were carried out before treatment, and after two cycles of chemotherapy, on patients treated with pemetrexed and cisplatin...
January 3, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29298216/the-utility-of-myocardial-perfusion-imaging-before-renal-transplantation-a-retrospective-analysis
#16
Paul D Callan, Sunil Bhandari, Andrew L Clark, David Eadington, Emmanouil Papadopoulos, Ann C Tweddel
BACKGROUND: Renal transplantation (RT) reduces morbidity and mortality in patients with end-stage renal failure. Myocardial perfusion imaging provides prognostic information in patients with renal failure, but its role before transplantation remains unclear. We performed a retrospective review assessing the prognostic value of technetium-99m sestamibi myocardial perfusion imaging at a tertiary UK centre. PATIENTS AND METHODS: We included scans performed between 2005 and 2012...
January 2, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29257008/which-is-the-optimal-threshold-for-defining-functional-lung-in-single-photon-emission-computed-tomography-lung-perfusion-imaging-of-lung-cancer-patients
#17
Xiuping Ding, Xianfeng Man, Mingping Sun, Jun Xing, Tingyong Fan, Min Gao, Hongjiang Yan, Baosheng Li
PURPOSE: The aim of this study was to investigate the optimal threshold for the functional lung (FL) definition of single-photon emission computed tomography (SPECT) lung perfusion imaging. PATIENTS AND METHODS: Forty consecutive stage III non-small-cell lung cancer patients underwent SPECT lung perfusion scans and PET/CT scans for treatment planning, and the images were coregistered. Total lung and perfusion lung volumes corresponding to 10, 20, …, 60% of the maximum SPECT count were segmented automatically...
December 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29257007/apoptosis-and-cell-proliferation-in-short-term-and-long-term-effects-of-radioiodine-131-induced-kidney-damage-an-experimental-and-immunohistochemical-study
#18
Nihat Yumusak, Murat Sadic, Gozde Yucel, Hasan I Atilgan, Gokhan Koca, Meliha Korkmaz
OBJECTIVE: Radioiodine-131 is a radionuclide that is used for therapeutic purposes in hyperthyroidism and thyroid cancer. The aim of this study was to evaluate apoptotosis and proliferative changes in radioiodine-related kidney damage. MATERIALS AND METHODS: Three groups (n=10/group) of rats were used as follows: the rats were in group 1 untreated, and the rats in groups 2 and 3 were treated once with oral radioiodine (111 MBq). The animals in group 2 were killed at the end of the seventh day and the rats in group 3 were killed at the end of the 10th week...
December 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29257006/68ga-psma-hbed-cc-pet-ct-imaging-in-black-versus-white-south-african-patients-with-prostate-carcinoma-presenting-with-a-low-volume-androgen-dependent-biochemical-recurrence-a-prospective-study
#19
Thabo Lengana, Christophe van de Wiele, Ismaheel Lawal, Alex Maes, Thomas Ebenhan, Tebatso Boshomane, Jan R Zeevaart, Alfred Ankrah, Neo Mokgoro, Mariza Vorster, Mike Sathekge
OBJECTIVE: To compare the diagnostic accuracy of Ga-prostate-specific membrane antigen (PSMA)-HBED-CC PET/computed tomography (CT) imaging for the detection of androgen-dependent recurrent prostate carcinoma (ADPC) in Black South Africans (BSAs) versus White South Africans (WSAs) with increasing serum prostate-specific antigen (PSA) values below or equal to 10 ng/ml. PATIENTS AND METHODS: A total of 61 patients with ADPC were prospectively included in the study (mean age: 66...
December 18, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29227348/quantitative-pet-ct-in-clinical-practice-assessing-the-agreement-of-pet-tumor-indices-using-different-clinical-reading-platforms
#20
Joyce C Mhlanga, Alin Chirindel, Martin A Lodge, Richard L Wahl, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to determine whether various fluorine-18-fluorodeoxyglucose PET/CT-derived parameters used in oncology vary significantly depending on the interpretation software systems used in clinical practice for multiple human solid tumors. PATIENTS AND METHODS: A total of 120 fluorine-18-fluorodeoxyglucose PET/CT studies carried out in patients with pancreatic, lung, colorectal, and head and neck cancers were evaluated retrospectively on two different vendor software platforms including Mirada and MIMVista...
December 8, 2017: Nuclear Medicine Communications
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