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Nuclear Medicine Communications

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https://www.readbyqxmd.com/read/28538080/formulation-and-characterization-of-lutetium-177-labeled-stannous-tin-colloid-for-radiosynovectomy
#1
Geetanjali Arora, Manoranjan Singh, Pragati Jha, Sarthak Tripathy, Chandrasekhar Bal, Anirban Mukherjee, Shamim A Shamim
OBJECTIVE: Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, followed by in-vitro and in-vivo characterization. METHODS: Stannous chloride (SnCl2) solution and Lu were heated together, the pH was adjusted, and the particles were recovered by centrifugation...
May 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28509766/brown-adipose-tissue-detected-by-pet-ct-imaging-is-associated-with-less-central-obesity
#2
Aileen L Green, Ulas Bagci, Sarfaraz Hussein, Patrick V Kelly, Razi Muzaffar, Brent A Neuschwander-Tetri, Medhat M Osman
PURPOSE: This retrospective review was performed to determine whether patients with brown adipose tissue (BAT) detected by fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging have less central obesity than BMI-matched control patients without detectable BAT. PATIENTS AND METHODS: Thirty-seven adult oncology patients with F-FDG BAT uptake were retrospectively identified from PET/CT studies from 2011 to 2013. The control cohort consisted of 74 adult oncology patients without detectable F-FDG BAT uptake matched for BMI/sex/season...
May 15, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28489691/optimal-injected-dose-ratio-of-a-very-rapid-1-day-protocol-of-myocardial-perfusion-imaging-with-cadmium-zinc-telluride-single-photon-emission-tomography-simulation-and-phantom-study
#3
Minako Shinjyo, Maho Naniwa, Narumi Kubo, Yoshihiro Nishimura, Keisuke Kiso, Kazuki Fukuchi
OBJECTIVE: Cadmium-zinc-telluride detectors enable shorter acquisition durations in myocardial perfusion imaging (MPI), but the time interval of sequential scanning is still unchanged in clinical practice. We designed a very rapid 1-day protocol of MPI using cadmium-zinc-telluride single-photon emission tomography and evaluated the optimal dose ratio between two scanning acquisitions by means of simulations and phantom experiments. METHODS: We intended to perform a 1-day MPI within 140 min and simulate radioactivities in the second scan under various injected dose ratios...
May 9, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28489689/half-body-single-photon-emission-computed-tomography-with-resolution-recovery-for-the-evaluation-of-metastatic-bone-disease-implementation-into-routine-clinical-service
#4
Michael B Hanney, Philip G Hillel, Andrew D Scott, Eleanor Lorenz
OBJECTIVES: Typically, scintigraphic evaluation of metastatic bone disease uses planar imaging. Although single photon emission computed tomography (SPECT) offers increased clinical utility, the acquisition time necessary to cover the required scan range (at our centre, skull vertex to mid-femur) has made its use in place of planar imaging impracticable. Recently, reconstruction with resolution recovery (RR) has allowed SPECT acquisition times to be shortened while maintaining acceptable image quality...
May 9, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28489688/hybrid-pet-mri-based-delineation-of-gross-tumor-volume-in-head-and-neck-cancer-and-tumor-parameter-analysis
#5
Jie-Tao Ma, Cheng-Bo Han, Jia-He Zheng, Hong-Zan Sun, Shao-Min Zhang, Jun Xin, Qi-Yong Guo
OBJECTIVES: Accurate target delineation allows an increase in radiation dose to the target tumor while reducing damage to the surrounding normal tissue. However, there is currently no standard for evaluating volumes measured by different imaging modalities. The aim of this study is to evaluate the feasibility of contouring gross tumor volume (GTV) by PET/MRI in head and neck cancer, and to define an adaptive threshold level (aTL) for delineating the biological target volume (BTV). PATIENTS AND METHODS: Eighteen head and neck cancer patients underwent time of flight PET/MRI before chemoradiotherapy...
May 9, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28471845/early-efficacy-of-and-toxicity-from-lutetium-177-dotatate-treatment-in-patients-with-progressive-metastatic-net
#6
Deborah Pencharz, Martin Walker, Mehmet Yalchin, Ann-Marie Quigley, Martyn Caplin, Christos Toumpanakis, Shaunak Navalkissoor
OBJECTIVE: Lutetium-177 DOTA-D-Phe1-Tyr3-octreotide (Lu-DOTATATE) is a treatment option for patients with well-differentiated metastatic neuroendocrine tumours. Our centre started administering this therapy in 2012. The aim of this study was therefore to analyse the first cohort of patients treated with Lu-DOTATATE to determine its early efficacy and toxicity. PATIENTS AND METHODS: We retrospectively analysed patient, tumour and treatment characteristics, end-of-treatment outcome, time to progression and toxicity in 79 consecutive patients treated with Lu-DOTATATE who had progressive NET according to Response Evaluation Criteria in Solid Tumours criteria...
May 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28471844/image-characteristics-and-classification-of-salivagram-in-the-diagnosis-of-pulmonary-aspiration-in-children
#7
Ha Wu, Ruifang Zhao
PURPOSE: A salivagram is a common method capable of detecting pulmonary aspiration. This investigation focused on describing the characteristics of salivagram and classifying the image to increase the clinical value of this imaging method. MATERIALS AND METHODS: A retrospective analysis was carried out of 428 patients (aged 1-36 months, mean age 4.5 months) diagnosed with respiratory tract infection and suspect pulmonary aspiration subjected to a salivagram, and the resulting images were classified on the basis of their features...
May 3, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28452796/uk-audit-of-quantitative-thyroid-uptake-imaging
#8
Jonathan C Taylor, Anthony W Murray, David O Hall, Mark C Barnfield, Emma R O'Shaugnessy, Kathryn J Carson, James Cullis, David J Towey, Bob Kenny
AIM: A national audit of quantitative thyroid uptake imaging was conducted by the Nuclear Medicine Software Quality Group of the Institute of Physics and Engineering in Medicine in 2014/2015. The aims of the audit were to measure and assess the variability in thyroid uptake results across the UK and to compare local protocols with British Nuclear Medicine Society (BNMS) guidelines. PARTICIPANTS AND METHODS: Participants were invited through a combination of emails on a public mailbase and targeted invitations from regional co-ordinators...
April 27, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28445243/harmonizing-standardized-uptake-value-recovery-between-two-pet-ct-systems-from-different-manufacturers-when-using-resolution-modelling-and-time-of-flight
#9
Ian S Armstrong, Katharine E Thomson, Lisa M Rowley, Daniel R McGowan
PET iterative reconstruction algorithms with resolution modelling (RM) can be used to improve spatial resolution in the images. However, RM has a significant impact on quantification, which raises issues for harmonization across multicentre networks or collaborations. This investigation compared quantification from two modern time-of-flight (TOF) PET/CT systems from different manufacturers with RM with the intention to harmonize recovery. Images of a National Electrical Manufacturers Association image quality phantom with a sphere-to-background concentration ratio of 4 : 1 were acquired on a GE Discovery 710 and a Siemens Biograph mCT and reconstructed with RM and TOF...
April 25, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28505040/news-and-views-june-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28489690/measurement-uncertainty-of-lesion-and-reference-mediastinum-standardized-uptake-value-in-lung-cancer
#11
Eric Laffon, Noel Milpied, Roger Marthan
OBJECTIVE: To assess standardized uptake value (SUV) measurement uncertainty (MU) of lung cancer lesions with uptake greater than mediastinum but less than or equal to the liver and that of the mediastinum blood pool, and to compare lesion SUV with mediastinum SUV by assessing MU of their ratio. PATIENTS AND METHODS: Dynamic PET data involving 10 frames were retrospectively analyzed in 10 patients, yielding maximal SUV of 25 lesions (Lesion-SUVmax), 10 mediastinum SUV, either maximal or mean (Med-SUVmax, Med-SUVmean), 25 Rmax ratios (=Lesion-SUVmax/Med-SUVmax), and 25 Rmean ratios (=Lesion-SUVmax/Med-SUVmean)...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28452797/a-national-survey-of-computed-tomography-doses-in-hybrid-pet-ct-and-spect-ct-examinations-in-the-uk
#12
Gareth R Iball, Natalie A Bebbington, Maria Burniston, Sue Edyvean, Louise Fraser, Peter Julyan, Nasreen Parkar, Tim Wood
OBJECTIVES: The aim of this study was to conduct a nationwide survey of computed tomography (CT) doses for a wide range of PET-CT and single photon emission computed tomography-computed tomography (SPECT-CT) imaging procedures, with the aim of generating proposed UK national diagnostic reference levels (NDRLs). METHODS: CT protocol and dosimetry data for three PET-CT and seven SPECT-CT examinations were gathered from centres across the UK. Data were divided according to CT purpose (attenuation correction, localization or diagnostic) and third quartile values of scanner average dose metrics were used to generate suggested NDRLs for a range of examination and CT purpose combinations...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430742/utility-of-single-photon-emission-tomography-computed-tomography-for-sentinel-lymph-node-localization-in-breast-cancer-patients
#13
Agnieszka Giżewska, Ewa Witkowska-Patena, Sebastian Osiecki, Andrzej Mazurek, Zofia Stembrowicz-Nowakowska, Mirosław Dziuk
OBJECTIVES: Sentinel lymph node (SLN) mapping is currently a routine technique in breast cancer management and preoperative scintigraphic imaging plays a crucial role in the process of SLN detection. The guidelines recommend performing planar acquisition and optional single-photon emission tomography/computed tomography (SPECT/CT) imaging. The aim of this study was to verify whether routine performing of SPECT/CT in addition to planar imaging increases the sensitivity of SLN detection in patients with early-stage breast cancer...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430741/utility-of-8%C3%A2-h-and-time-decay-corrected-acquisition-scintigraphy-with-in-vitro-labeled-white-blood-cells-for-the-diagnosis-of-osteoarticular-infection
#14
Edel Noriega-Álvarez, Guillermo A Martínez Pimienta, Ana M Benítez Segura, María T Bajén Lázaro, Alba Rodríguez-Gasén, Julio Rodríguez-Rubio Corona, Jaime Mora-Salvadó
INTRODUCTION: Except in the spine, labeled white-blood cell scintigraphy (WBCS) with image acquisition up to 24 h is the nuclear medicine test of choice for diagnosing osteoarticular infection. However, distinguishing between inflammation and infection is a challenge. OBJECTIVES: The first aim of this study was to verify earlier research studies that used 4 and 24 h time decay-corrected acquisition (TDCA) to differentiate infection from inflammation. The second aim was to analyze whether 8 h acquisition (1-day protocol) yielded similar results as 20-24 h acquisition...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430740/low-dose-computed-tomography-scans-with-automatic-exposure-control-for-patients-of-different-ages-undergoing-cardiac-pet-ct-and-spect-ct
#15
Ching-Ching Yang, Bang-Hung Yang, Chun-Yuan Tu, Tung-Hsin Wu, Shu-Hsin Liu
PURPOSE: This study aimed to evaluate the efficacy of automatic exposure control (AEC) in order to optimize low-dose computed tomography (CT) protocols for patients of different ages undergoing cardiac PET/CT and single-photon emission computed tomography/computed tomography (SPECT/CT). METHODS: One PET/CT and one SPECT/CT were used to acquire CT images for four anthropomorphic phantoms representative of 1-year-old, 5-year-old and 10-year-old children and an adult...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430739/downstream-indication-to-revascularization-following-hybrid-cardiac-pet-mri-preliminary-results
#16
Julien Priamo, Dionysos Adamopoulos, Oliver Rager, Angela Frei, Stephane Noble, David Carballo, Osman Ratib, René Nkoulou
BACKGROUND: Hybrid PET/MRI allows the acquisition of both fluorine-18-fluorodeoxyglucose (F-FDG) PET and cardiac magnetic resonance (CMR) during one session. Whether this will result in different referral to coronary revascularization (CR) is unknown. We compared this new hybrid method with all-nuclear/all-CMR methods in the assessment of viable myocardium and in downstream referral to CR. PATIENTS AND METHODS: Overall, 12 patients with rest perfusion defects on a single photon emission computed tomography (SPECT) were recruited for cardiac viability assessment using a PET/MRI device...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430738/three-dimensional-fractal-analysis-of-99mtc-maa-spect-images-in-chronic-thromboembolic-pulmonary-hypertension-for-evaluation-of-response-to-balloon-pulmonary-angioplasty-association-with-pulmonary-arterial-pressure
#17
Yasuhiro Maruoka, Michinobu Nagao, Shingo Baba, Takuro Isoda, Yoshiyuki Kitamura, Yuzo Yamazaki, Koichiro Abe, Masayuki Sasaki, Kohtaro Abe, Hiroshi Honda
OBJECTIVE: Balloon pulmonary angioplasty (BPA) is used for inoperable chronic thromboembolic pulmonary hypertension (CTEPH), but its effect cannot be evaluated noninvasively. We devised a noninvasive quantitative index of response to BPA using three-dimensional fractal analysis (3D-FA) of technetium-99m-macroaggregated albumin (Tc-MAA) single-photon emission computed tomography (SPECT). PATIENTS AND METHODS: Forty CTEPH patients who underwent pulmonary perfusion scintigraphy and mean pulmonary arterial pressure (mPAP) measurement by right heart catheterization before and after BPA were studied...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28410290/diagnostic-and-prognostic-impact-of-fluorine-18-fluorodeoxyglucose-pet-ct-in-preoperative-and-postoperative-setting-of-breast-cancer-patients
#18
Laura Evangelista, Anna R Cervino, Silvia Michieletto, Tania Saibene, Cristina Ghiotto, Valentina Guarneri, Pierfranco Conte, Pasquale Reccia, Giorgio Saladini
PURPOSE: The aim of this study was to assess the diagnostic and prognostic value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in patients with breast cancer (BC) in the preoperative and the postoperative setting. PATIENTS AND METHODS: Between 2011 and 2015, we prospectively enrolled 275 patients (mean age: 53 years) with BC (stage I-III; triple-negative or HER2-positive cancer). One-hundred and forty-nine (54.2%) patients underwent F-FDG PET/CT before neoadjuvant therapy and 126 (45...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28410289/initial-experience-with-real-time-hybrid-single-photon-emission-computed-tomography-computed-tomography-guided-percutaneous-transthoracic-needle-biopsy
#19
Qian Hua, Xiangyun Zhu, Lei Zhang, Yanjun Zhao, Ping Tang, Jianming Ni
The aim of this study was to explore a technique that uses real-time fusion image of single-photon emission computed tomography/computed tomography (SPECT/CT) to guide percutaneous transthoracic needle biopsy (PTNB) and test its feasibility and safety in patients. Twelve patients with intrathoracic lesions suspicious for malignancy underwent real-time 99m-technetium sestamibi SPECT/CT-guided PTNB. Chest SPECT/CT fusion images were used for biopsy planning and intraprocedure fusion of SPECT with guiding CT was used to adjust the puncture angle and direction...
June 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28410288/the-utility-of-the-combination-of-a-spect-study-with-123i-fp-cit-of-dopamine-transporters-and-123i-mibg-myocardial-scintigraphy-in-differentiating-parkinson-disease-from-other-degenerative-parkinsonian-syndromes
#20
Naoto Uyama, Hideki Otsuka, Takayoshi Shinya, Yoichi Otomi, Masafumi Harada, Wataru Sako, Yuishin Izumi, Ryuji Kaji, Yuya Watanabe, Satoru Takashi, Yamato Kunikane
OBJECTIVE: Molecular imaging of nigrostriatal dopamine transporters (DAT) and sympathetic cardiac innervation with single-photon emission computed tomography (SPECT) are useful tools for differentiating idiopathic Parkinson disease (PD) from other degenerative parkinsonian syndromes (non-PD). Nevertheless, these modalities are often insufficient for achieving a definite diagnosis. The aims of this study were to evaluate the diagnostic accuracy of the combination of these tools. MATERIALS AND METHODS: The SPECT radiotracers [I]-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)-nortropane (FP-CIT) and meta-[I]-iodobenzylguanidine (MIBG) were used to research presynaptic dopaminergic projections (DAT SPECT) and myocardial adrenergic innervation (MIBG scintigraphy), respectively...
June 2017: Nuclear Medicine Communications
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