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Nuclear Medicine Communications

Vladimir R Vukomanovic, Milovan Matovic, Mirjana Doknic, Vesna Ignjatovic, Ivana Simic Vukomanovic, Svetlana Djukic, Miodrag Peulic, Aleksandar Djukic
BACKGROUND: The aim of this study was to evaluate the behavioral uptake and ability to diagnose pituitary adenoma (PA) using tumor-seeking radiopharmaceuticals, and to provide a semiquantitative analysis of tracer uptake in the pituitary region. PATIENTS AND METHODS: The study included 33 (13 hormonally active and 20 nonfunctioning) patients with PA and 45 control participants without pituitary involvement. All patients (n=78) underwent single photon emission computed tomography (SPECT) imaging with technetium-99m-labeled EDDA-hydrazinonicotinyl-tyr-octreotide (Tc-HYNIC-TOC), Tc(V)-DMSA and technetium-99m-hexakis-2-methoxyisobutylisonitrile (Tc-MIBI)...
October 16, 2018: Nuclear Medicine Communications
Shelvin K Vadi, Bhagwant R Mittal, Ashwani Sood, Gurpreet Singh, Amanjit Bal, Ashwin S Parihar, Anish Bhattacharya, Rajender K Basher, Rakesh Kapoor
PURPOSE: Male breast cancer (MBC) is a rare malignancy, with recurrence being one of the main adverse predictors for prognosis. The aim of the study was to evaluate the diagnostic and predictive value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in the setting of suspected recurrence of MBC. PATIENTS AND METHODS: Retrospective analysis of PET/CT findings was performed in 23 previously treated, histologically proven patients with MBC (mean age: 59.3±10.9 years; range: 36-79 years) with suspected recurrence...
October 11, 2018: Nuclear Medicine Communications
Guohua Shen, Ying Kou, Bin Liu, Rui Huang, Anren Kuang
OBJECTIVES: Preclinical studies showed that BRAF mutation significantly reduced radioiodine uptake and decreased the sensitivity to radioactive iodine (RAI) therapy. However, clinical data regarding its role in therapeutic decision making with respect to RAI therapy are currently insufficient. Thus, this study aimed to evaluate the effect of BRAF mutation on the clinical response to RAI therapy for papillary thyroid microcarcinoma (PTMC) with intermediate-risk to high-risk features. PATIENTS AND METHODS: From January 2012 and October 2015, consecutive patients with PTMC with intermediate-risk to high-risk features who underwent RAI therapy were retrospectively included...
October 11, 2018: Nuclear Medicine Communications
Ashwini Kalshetty, Anant Ramaswamy, Vikas Ostwal, Sandip Basu
BACKGROUND AND AIMS: Functioning and symptomatic disease resistant to conventional therapies constitutes a subset amongst neuroendocrine tumors (NETs) that are commonly considered for peptide receptor radionuclide therapy (PRRT). The aim of this study was to evaluate the efficacy of Lu-DOTATATE PRRT in this group with objective assessment criteria. MATERIALS AND METHODS: A total of 46 patients with refractory or progressive symptomatic GEP-NETs (previously treated at various stages with long-acting octreotide, chemotherapy, multikinase inhibitors, etc...
October 10, 2018: Nuclear Medicine Communications
Nina M Mansoor, Stefanie Thust, Vincenzo Militano, Francesco Fraioli
PET holds potential to provide additional information about tumour metabolic processes, which could aid brain tumour differential diagnosis, grading, molecular subtyping and/or the distinction of therapy effects from disease recurrence. This review discusses PET techniques currently in use for untreated and treated glioma characterization and aims to critically assess the evidence for different tracers ([F]Fluorodeoxyglucose choline and amino acid tracers) in this context.
October 9, 2018: Nuclear Medicine Communications
Maria F Villani, Armando Grossi, Bartolomeo Cassano, Milena Pizzoferro, Graziamaria Ubertini, Mariaconcetta Longo, Maria C Garganese
OBJECTIVE: Radioiodine treatment (RAI-T) of differentiated thyroid carcinoma (DTC) is important to avoid disease progression, in particular in pediatric patients. For these reasons, a diagnostic scan may be useful to assess therapeutic tailored activity. The purpose of our study was to evaluate the usefulness of diagnostic whole-body scan (WBS) with iodine-123 (I) in combination with recombinant human thyroid-stimulating hormone (rh-TSH; Thyrogen) (rh-TSH-Dx-WBS), in planning RAI-T or further surgery before RAI-T in pediatric DTC...
September 26, 2018: Nuclear Medicine Communications
Syed F A Rizvi, Saleha Tariq, Muhammad Mehdi
OBJECTIVES: Dactinomycin is a well-known antitumor-antibiotic drug isolated from soil bacterium Streptomyces, which exhibits broad-spectrum pharmacological and biochemical effects. In this study, dactinomycin was successfully labeled with technetium-99m for early diagnosis of bacterial infection and to discriminate it from acute inflammation. MATERIALS AND METHODS: Various labeling parameters such as pH, ligand concentration, reducing agent, and stabilizing agent were investigated...
September 25, 2018: Nuclear Medicine Communications
Sen Wang, Chao Liang, Li Zhao, Zhaowei Meng, Chunmei Zhang, Qiang Jia, Jian Tan, Hui Yang, Xiangxiang Liu, Xiaoran Wang
AIM: This study aimed to investigate the influence of radioactive iodine (RAI) therapy on liver function in patients with differentiated thyroid cancer (DTC), with emphasis on sex and dose accumulation. PATIENTS AND METHODS: Liver function after the first RAI ablation with ~3700 MBq (100 mCi) dosage was compared with baseline liver function in 357 patients with DTC (male: 110 and female: 247). Further comparisons were conducted in patients after regular and successive RAI therapies with available data, 126 patients (male: 37 and female: 89) with two RAI therapies, 52 patients (male: 16 and female: 36) with three RAI therapies, and 19 patients (male: 5 and female: 14) with four RAI therapies...
September 21, 2018: Nuclear Medicine Communications
Reiko Nakajima, Michinobu Nagao, Ryoko Ohashi, Yoshihiro Muragaki, Masayuki Nitta, Takashi Maruyama, Takashi Komori, Koichiro Abe, Takakazu Kawamata, Shuji Sakai
OBJECTIVE: To assess intratumoural metabolic heterogeneity using modified fractal analysis and to determine its prognostic significance in patients with glioma. PATIENTS AND METHODS: A total of 57 patients with newly diagnosed glioma who underwent methionine PET-computed tomography between August 2012 and January 2017 were enrolled. The requirement for informed consent was waived for this retrospective study. Tumour-to-normal tissue ratio, metabolic tumour volume, total lesion methionine uptake and modified fractal dimension (m-FD) were calculated for each tumour using methionine PET-computed tomography...
September 21, 2018: Nuclear Medicine Communications
Jianjun Xue, Yan Liu, Ting Ji, Aomei Zhao, Yiqian Liang, Huixing Deng, Qi Wang, Yuemin Zhang, Lulu Yang, Aimin Yang
OBJECTIVE: The aim of this study was to evaluate the value of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) imaging and ultrasound in preoperative localization of parathyroid adenoma (PA) and parathyroid hyperplasia (PH). PARTICIPANTS AND METHODS: A retrospective study of Tc-MIBI double-phase scintigraphy (DPS) was performed in 187 hyperparathyroidism cases with pathologically diagnosed PA or PH. Of these patients, 167 cases underwent ultrasound, and 146 cases underwent Tc-MIBI single-photon emission computed tomography/computed tomography (SPECT/CT)...
September 19, 2018: Nuclear Medicine Communications
Tomoyuki Fujioka, Kazunori Kubota, Yuka Kikuchi, Junichi Tsuchiya, Ukihide Tateishi, Mai Kasaharak, Goshi Oda, Toshiyuki Ishiba, Tsuyoshi Nakagawa
PURPOSE: This study investigated the correlation between fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) and clinicopathological factors in patients with mucinous breast carcinoma and assessed the feasibility of using F-FDG-PET/CT in evaluating tumors. PATIENTS AND METHODS: We retrospectively examined 42 consecutive patients with pathologically proven mucinous breast carcinoma who preoperatively underwent F-FDG-PET/CT. In addition, we compared F-FDG uptake with clinicopathological characteristics...
September 18, 2018: Nuclear Medicine Communications
Cihan Gündoğan, Tevfik F Çermik, Erkan Erkan, Aytül H Yardimci, Kemal Behzatoğlu, Gamze Tatar, Oğuzhan Okçu, Mahmut G Toktaş
PURPOSE: The objectives of this prospective study are to compare intravenous contrast-enhanced (CE) fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CE F-FDG PET/CT) with conventional methods (CT/MRI) and to evaluate the relationship of maximum standardized uptake value (SUVmax) with Fuhrman grade in patients with renal tumors. PATIENTS AND METHODS: A total of 62 patients [35 males and 27 females; mean age 55.8±12.7 (range: 27-81) years] were enrolled in the study...
September 18, 2018: Nuclear Medicine Communications
Tuija S Kangasmaa, Chris Constable, Antti O Sohlberg
OBJECTIVE: Quantitative I and I single-photon emission computed tomography (SPECT) is hampered by down-scatter from the high-energy peaks. This paper presents a down-scatter compensation method, where down-scatter generated in the patient and gamma camera collimator and detector is modelled using Monte Carlo simulation in the ordered subsets expectation maximization SPECT reconstruction algorithm. MATERIALS AND METHODS: The new down-scatter compensation method was compared with conventional triple energy window (TEW) scatter compensation and Gaussian convolution-based forced detection Monte Carlo methods...
September 14, 2018: Nuclear Medicine Communications
Alessio Annovazzi, Sandra Rea, Patrizia Vici, Alessandra Fabi, Rosa Sciuto
OBJECTIVE: The aim was to investigate the diagnostic potential of dual-time-point F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in patients with breast cancer with known or suspected liver metastases and to assess its clinical value on clinical management. PATIENTS AND METHODS: A total of 151 consecutive patients with breast cancer who underwent F-FDG PET/CT scan for staging or restaging, in whom an additional delayed scan of the liver was performed, were retrospectively evaluated...
September 13, 2018: Nuclear Medicine Communications
Osayande Evbuomwan, Khushica Purbhoo, Mboyo D T Vangu
OBJECTIVE: The aim of the study was to assess the efficacy of technetium 99m-methyl diphosphonate (Tc-MDP) and technetium 99m-methoxyisobutylisonitrile (Tc-MIBI) as radioaerosol alternatives to technetium 99m-diethylenetriaminepentacetate (Tc-DTPA) in the evaluation of pulmonary thromboembolism, as the direct consequence of the possible outcome could be cost saving. PATIENTS AND METHODS: Patients referred to our institution from August 2015 to July 2017 for a ventilation-perfusion scan who fulfilled the inclusion criteria were enrolled into the study as participants...
September 13, 2018: Nuclear Medicine Communications
Arun Sasikumar, Ajith Joy, Ambikalmajan M R Pillai, Karuna E Oommen, Sudin Somarajan, Vikraman Kaithavelil Raman, Renu Thomas, Dhanya Dinesh
OBJECTIVE: To assess the feasibility of gallium 68 (Ga)-prostate specific membrane antigen (PSMA) PET/computed tomography (CT) to identify patients who truly harbor clinically significant prostate cancer (PCa) in a cohort of patients with clinical and biochemical/radiological suspicion of PCa. PATIENTS AND METHODS: A total of 118 patients with suspected PCa who underwent Ga-PSMA PET/CT between May 2015 and June 2016 were prospectively included. Final decision on performing biopsy was left to the referring urologist after considering the clinical data, scan findings and discussion with the patient...
September 13, 2018: Nuclear Medicine Communications
Mona Mosayebnia, Maliheh Hajiramezanali, Soraya Shahhosseini, Atefeh Hajiagha Bozorgi, Farzad Kobarfard, Sedigheh Rezaeianpour
OBJECTIVE: With respect to the reported promising results of cyclic peptide CGPRPPC in early detection of thrombotic lesions, we developed a practical approach for technetium-99m labeling of this peptide using the Glycine-Alanine-Glycine-Glycine (GAGG) sequence as a chelating moiety. MATERIALS AND METHODS: The peptide conjugated to GAGG was prepared using the solid-phase method. The optimization of radiolabeling conditions was performed on the basis of such variables as incubation time, reaction temperature, pH, and concentration of peptide and stannous chloride...
September 12, 2018: Nuclear Medicine Communications
Kyoungjune Pak, Seunghyeon Shin, So Jung Kim, Keunyoung Kim, Youngduk Seo, Seong-Jang Kim, In Joo Kim
OBJECTIVES: As PET has become a standard of treatment in patients with cancer, publications of oncologic PET have grown sharply. We aimed to organize the data of meta-analyses of oncologic PET and assess the quality of studies. MATERIALS AND METHODS: The inclusion criteria were studies that meta-analyzed to combine the data from multiple studies of oncologic PET. We used the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) to assess the reporting quality of the included studies...
September 12, 2018: Nuclear Medicine Communications
Le Zhang, Hongzan Sun, Siyao Du, Weina Xu, Jun Xin, Qiyong Guo
PURPOSE: The aim of this study was to investigate the value of five typical fluorine-18-fluorodeoxyglucose PET/computed tomography (CT) parameters (including SUVmax, SUVmean, SUVpeak, MTV and TLG) in the reflecting aggressiveness and predicting prognosis in patients with early-stage cervical cancer. PATIENTS AND METHODS: Our study enrolled 85 primary cervical cancer patients who underwent preoperative fluorine-18-fluorodeoxyglucose PET/CT scans. We investigated the association of five parameters derived from PET/CT with clinicopathological characteristics...
September 10, 2018: Nuclear Medicine Communications
Ismaheel O Lawal, Alfred O Ankrah, Gbenga O Popoola, Nozipho E Nyakale, Tebatso G Boshomane, Florette Reyneke, Thabo Lengana, Mariza Vorster, Mike M Sathekge
OBJECTIVES: Baseline metabolic metrics on fluorine-18-fluorodeoxyglucose PET (F-FDG PET) have prognostic value in Hodgkin lymphoma. International Prognostic Score (IPS) is used in the risk stratification of Hodgkin lymphoma. We compared the metabolic indices in HIV-infected and the IPS in HIV-infected and uninfected patients with Hodgkin lymphoma. PATIENTS AND METHODS: We retrospectively reviewed the data of HIV-infected and HIV-uninfected patients with classic Hodgkin lymphoma who had F-FDG PET for staging and compared the maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, and total lesion glycolysis between the two groups...
September 10, 2018: Nuclear Medicine Communications
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