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Nuclear Medicine Communications

Krishan Kant Agarwal, Anirban Mukherjee, ArunRaj St, Madhavi Tripathi, Chandrasekhar Bal
OBJECTIVE: To evaluate the incremental value of technetium-99m methylene diphosphonate (Tc-MDP) single-photon emission computed tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT for the diagnosis of active condylar hyperplasia (CH). PATIENTS AND METHODS: Data of 21 patients (mean age: 21.9±5.3 years, 10 males, 11 females) who underwent Tc-MDP BS along with regional SPECT/CT for the diagnosis of active CH were retrospectively evaluated...
October 19, 2016: Nuclear Medicine Communications
Bert-Ram Sah, Paul Stolzmann, Gaspar Delso, Scott D Wollenweber, Martin Hüllner, Yahya A Hakami, Marcelo A Queiroz, Felipe de Galiza Barbosa, Gustav K von Schulthess, Carsten Pietsch, Patrick Veit-Haibach
PURPOSE: To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies. METHODS: A total of 410 reconstructions of 41 fluorine-18 fluorodeoxyglucose-PET/CT studies of 41 patients with a total of 2010 lesions were analyzed by two experienced nuclear medicine physicians. Images were reconstructed with BSREM (with four different β values) or ordered subset expectation maximization (OSEM) algorithm with/without time-of-flight (TOF/non-TOF) corrections...
October 18, 2016: Nuclear Medicine Communications
Rajeev Kumar, Rajendra G Sonkawade, Anil K Pandey, Madhavi Tripathi, Nishikant A Damle, Praveen Kumar, Chandra S Bal
OBJECTIVE: The aim of this article was to share 10 years of operational experience of medical cyclotron and to provide working knowledge on the same. This experience has helped us gain working knowledge on cyclotron operation with practical points, which may help in improving F yield, minimizing the breakdown time, and help in the prevention of the occurrence of unusual events. MATERIALS AND METHODS: Our facility has a self-shielded radioisotope delivery system eclipse 111 medical cyclotron with an 11 MeV proton beam in use for the past 10 years to produce positron emitters - namely, F, N, and F-2 gas - for PET imaging...
October 13, 2016: Nuclear Medicine Communications
Zong Ruilong, Xie Daohai, Geng Li, Wang Xiaohong, Wang Chunjie, Tian Lei
OBJECTIVES: To carry out a meta-analysis on the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (PET/CT) for the evaluation of solitary pulmonary nodules. MATERIALS AND METHODS: In the meta-analysis, we performed searches of several electronic databases for relevant studies, including Google Scholar, PubMed, Cochrane Library, and several Chinese databases. The quality of all included studies was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2)...
October 12, 2016: Nuclear Medicine Communications
Ashu Rastogi, Anish Bhattacharya, Mahesh Prakash, Sarika Sharma, Bhagwant R Mittal, Niranjan Khandelwal, Anil Bhansali
OBJECTIVE: Diabetic foot osteomyelitis (DFO) is difficult to diagnose in the presence of Charcot's neuroarthropathy (CN) and bone biopsy is not always possible. We aimed to assess the efficacy of PET/computed tomography using F-fluoride (F-fluoride PET/CT) and fluorine-18-fluorodeoxyglucose-labeled autologous leukocytes (F-FDG-LL PET/CT) in comparison with contrast-enhanced MRI (CEMRI) for the detection of DFO. PATIENTS AND METHODS: Thirty-two patients with chronic CN and foot ulcer suspected of having DFO were prospectively evaluated...
October 4, 2016: Nuclear Medicine Communications
Babak Fallahi, Davood Beiki, Yalda Salehi, Alireza Emami-Ardekani, Armaghan Fard-Esfahani, Farahnaz Aghahosseini, Mahdi Haghighatafshar, Mohammad Eftekhari
OBJECTIVE: With respect to the equivocal value of the reverse perfusion pattern (RPP) in technetium-99m (Tc)-sestamibi myocardial perfusion imaging, a study was carried out to evaluate this pattern in association with the presence or absence of coronary artery disease (CAD) and other underlying factors, mainly the time of acquisition and the presence of intense visceral uptake. PATIENTS AND METHODS: We prospectively studied 102 patients with a moderate risk of CAD (41 men and 61 women, mean age: 56...
October 4, 2016: Nuclear Medicine Communications
Philippa L Bresser, Mike M Sathekge, Chandra R Makanjee, Delene Van Wyk, Mariza Vorster
INTRODUCTION: Various techniques have been used in an attempt to reduce interfering extracardiac activity in myocardial perfusion imaging with inconsistent results. The aim of this study was to investigate the effect of a combined intervention on the frequency and intensity of interfering extracardiac activity. METHODS: Patients (n=230) routinely referred for a 2-day stress-rest myocardial perfusion examination were assigned randomly to one of two groups. Group A (n=114) received a single intervention (diluted lemon juice) before stress imaging and a combined intervention (diluted lemon juice and soda water) before rest imaging...
October 4, 2016: Nuclear Medicine Communications
Sitah F Alanazi, Khalid S Alzimami, Magdy M Ghannam, Ibrahim J Aljammaz, Faisal Alrumayan, Salem A Sassi
PURPOSE: Interest in PET imaging using zirconium-89 (Zr) (t1/2=78.41 h)-labeled tracers for the tracking and quantification of monoclonal antibodies (mAbs) is growing, mainly because of its well-matched physical half-life with the biological half-life of intact mAbs. This study aims to evaluate the imaging characteristics of Zr-PET in comparison with those obtained using fluorine-18 fluorodeoxyglucose (F-FDG) PET (gold standard tracer in PET imaging) using a Time-Of-Flight (TOF) PET/computed tomography (CT) scanner...
October 4, 2016: Nuclear Medicine Communications
Minjung Seo, Byung Kyun Ko, Soon Young Tae, Su-Jin Koh, Young Ju Noh, Hye-Jeong Choi, Kyungkyg Bae, Minseo Bang, Sungmin Jun, Seol Hoon Park
AIM: Although rib uptake is frequently detected in follow-up bone scans of breast cancer patients, few studies have assessed its clinical significance. PATIENTS AND METHODS: Among 1208 breast cancer patients who underwent a bone scan between 2011 and 2014, 157 patients presented with newly detected rib uptake at follow-up. Patients who had underlying bone metastases (n=8) or had simultaneous new uptake in sites other than the rib (n=13) were excluded. The patients enrolled finally were those who had purely rib uptakes...
September 15, 2016: Nuclear Medicine Communications
Heejung Kim, Sung-Jin Lee, Jin Su Kim, Cynthia Davies-Venn, Hong-Jun Cho, Samuel J Won, Eden Dejene, Zhengsheng Yao, Insook Kim, Chang H Paik, David A Bluemke
OBJECTIVES: The aim of the study is to evaluate the pharmacokinetics and microbiodistribution of Cu-labeled collagen-binding peptides. METHODS: The affinity constant (KD), association (ka), and dissociation rate constant (kd) for the peptide collagelin or its analog (named CRPA) binding to collagen were measured by biolayer interferometric analysis. Rats (n=4-5) with myocardial infarction or normal were injected intravenously with the Cu-labeled peptides or Cu-DOTA as a control...
September 10, 2016: Nuclear Medicine Communications
Neena Kalsy, Sobhan Vinjamuri
No abstract text is available yet for this article.
September 8, 2016: Nuclear Medicine Communications
Martin Barrio, Johannes Czernin, Michael W Yeh, Miguel F Palma Diaz, Pawan Gupta, Martin Allen-Auerbach, Christiaan Schiepers, Ken Herrmann
BACKGROUND: The clinical significance of incidental thyroid abnormalities discovered in fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) (FDG PET/CT) studies remains controversial. The aim of this large retrospective study was to (a) determine the prevalence of focal F-FDG thyroid uptake on whole-body F-FDG PET/CT studies carried out for nonthyroid cancers and (b) to test whether intense focal F-FDG thyroid uptake is associated with malignancy. MATERIALS AND METHODS: A total of 11 921 F-FDG PET/CT studies in 6216 patients carried out at our institution between January 2012 and December 2014 were analyzed...
September 8, 2016: Nuclear Medicine Communications
Wouter P Kluijfhout, Wessel M C M Vorselaars, Sandra A M van den Berk, Menno R Vriens, Inne H M Borel Rinkes, Gerlof D Valk, Thijs van Dalen, John M H de Klerk, Bart de Keizer
BACKGROUND: Several reports have shown good performance of fluorine-18 fluorocholine (F-FCH) PET-computed tomography (CT) for parathyroid localization, although overall evidence remains scarce. We collected data from three institutions in the Netherlands and investigated the performance of F-FCH PET-CT as a second-line imaging modality. MATERIALS AND METHODS: We performed a retrospective review of all patients at least 18 years who underwent F-FCH PET-CT for biochemically proven hyperparathyroidism (HPT) and inconclusive ultrasound and sestamibi scintigraphy...
September 8, 2016: Nuclear Medicine Communications
Chalermrat Kaewput, Sobhan Vinjamuri
BACKGROUND: Ga-DOTA-conjugated peptide PET/CT is used widely for diagnosis and treatment planning in patients with neuroendocrine tumours. As nephrotoxicity is a major limiting factor during peptide receptor radionuclide therapy (PRRT), it is important to evaluate renal function before, during and after treatment. The aim of our study is to compare renal uptake of Ga-DOTANOC and estimated glomerular filtration rate (eGFR) before and after PRRT and to identify any surrogate indicators of renal toxicity...
September 8, 2016: Nuclear Medicine Communications
Shanzhen He, Ganghua Tang, Kongzhen Hu, Shuxia Wang, Tingting Huang, Xiang Liang
OBJECTIVE: The new tumor probe 5-([C]-methyloxy)-L-tryptophan ([C]-L-CMTP) had been found to show high uptake in tumor tissue in our previous report; however, the pharmacokinetic properties of [C]-L-CMTP have not been characterized. In this present study, we evaluated the potential of [C]-L-CMTP as a PET probe for tumor imaging. METHODS: The biodistribution of [C]-L-CMTP was determined in healthy mice and the incorporation of [C]-L-CMTP into proteins was investigated...
September 8, 2016: Nuclear Medicine Communications
Cem Onal, Nese Torun, Ozan C Guler, Berna A Yildirim
BACKGROUND: This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose (F-FDG)-PET for predicting overall survival (OS) and disease-free survival (DFS) in oesophageal cancer patients after definitive chemoradiotherapy (CRT) and prognostic importance of metabolic response detected by post-treatment PET at least 3 months after completing CRT. MATERIALS AND METHODS: Data from 58 oesophageal cancer patients receiving definitive CRT were retrospectively analysed...
September 8, 2016: Nuclear Medicine Communications
Laura Evangelista, Fabio Zattoni, Robert J Karnes, Giacomo Novara, Val Lowe
To provide a systematic review of recently published reports and carry out a meta-analysis on the use of radiolabeled choline PET/computed tomography (CT) as a guide for salvage lymph node dissection (sLND) in prostate cancer patients with biochemical recurrence after primary treatments. Bibliographic database searches, from 2005 to May 2015, including Pubmed, Web of Science, and TripDatabase, were performed to find studies that included only patients who underwent sLND after radiolabeled choline PET/CT alone or in combination with other imaging modalities...
August 22, 2016: Nuclear Medicine Communications
Bita Dadpour, Vahid R Dabbagh Kakhki, Reza Afshari, Masoumeh Dorri-Giv, Seyed A R Mohajeri, Somayeh Ghahremani
OBJECTIVES: Methamphetamine (MA) is associated with alterations of cardiac structure and function, although it is less known. In this study, we assessed possible abnormality in myocardial perfusion and left ventricular function using gated myocardial perfusion SPECT. METHODS: Fifteen patients with MA abuse, on the basis of Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) MA dependency determined by Structured Clinical Interview for DSM-IV, underwent 2-day dipyridamole stress/rest Tc-sestamibi gated myocardial perfusion SPECT...
August 17, 2016: Nuclear Medicine Communications
Hugo J A Adams, Thomas C Kwee
No abstract text is available yet for this article.
August 5, 2016: Nuclear Medicine Communications
Jae Pil Hwang, Ilhan Lim, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
PURPOSE: The aim of this retrospective study was to determine whether glucose metabolism assessed by fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) provides prognostic information independent of established prognostic factors in patients with gastric lymphoma. PATIENTS AND METHODS: We reviewed the medical records of 86 patients retrospectively (men, 42; women, 44; mean age 58±13 years) with pathologically proven gastric lymphoma (34 mucosa-associated lymphoid tissue and 52 aggressive non-Hodgkin's lymphoma)...
August 1, 2016: Nuclear Medicine Communications
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