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Nuclear Medicine Communications

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https://www.readbyqxmd.com/read/30531407/first-comparative-results-about-the-direct-effect-of-traditional-cigarette-and-e-cigarette-smoking-on-lung-alveolocapillary-membrane-using-dynamic-ventilation-scintigraphy
#1
Sandor Barna, David Rózsa, Jozsef Varga, Andrea Fodor, Maria Szilasi, Laszlo Galuska, Ildiko Garai
INTRODUCTION: Dynamic inhalation scintigraphy (DIS) with technetium-99m-diethylenetriamine-pentaacetate aerosol is a useful nuclear medicine procedure for staging and monitoring the damage of alveolocapillary membrane. The e-cigarette is a new popular smoking device producing vapor from the nicotine solution. Many studies have shown that e-cigarettes appear to be safer than smoking, but there are still debates to what extent e-cigarettes are less harmful than smoking.In this prospective, self-controlled study, we compared DIS results among volunteers smoking an e-cigarette and their results after they returned to traditional cigarette smoking for a week...
December 10, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30531406/incidence-and-severity-of-femoral-head-avascularity-after-femoral-neck-or-intertrochanteric-fractures-on-preoperative-bone-single-photon-emission-computed-tomography-computed-tomography-preliminary-study
#2
Yeon-Hee Han, Hwan-Jeong Jeong, Myung-Hee Sohn, Sun-Jung Yoon, Seok Tae Lim
OBJECTIVE: The aim of the present study was to evaluate the incidence and degree of femoral head avascularity depending on the types of femoral neck or intertrochanteric fractures using preoperative bone single photon emission computed tomography (SPECT)/computed tomography (CT). PATIENTS AND METHODS: A total of 131 patients with femoral neck or intertrochanteric fractures who underwent preoperative bone SPECT/CT were enrolled. Femoral head avascularity was evaluated using bone SPECT/CT images...
December 10, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30507749/the-use-of-single-photon-emission-computed-tomography-computed-tomography-in-detecting-multiple-metastatic-lymph-nodes-in-patients-with-breast-cancer
#3
Pavel I Krzhivitskii, Sergey N Novikov, Sergey V Kanaev, Petr V Krivorotko, Nadegda S Popova, Antonina V Chernaya, Olga A Klitcenko
AIM: The aim of the present study was to determine the accuracy of single-photon emission computed tomography-computed tomography (SPECT-CT) with technetium-99m-sestamibi (Tc-MIBI) for detecting multiple (>2 nodes) axillary lymph node involvement in patients with breast cancer (BC). PATIENTS AND METHODS: A total of 184 women with BC were examined. Clinically, axillary lymph nodes were classified as N0 in all cases. Patients underwent SPECT-CT breast and axillary region imaging 10-15 min after a 740 mBq intravenous injection of Tc-MIBI...
November 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30507748/sensitivity-of-fluorine-18-fluoromethylcholine-pet-ct-to-prostate-specific-antigen-over-different-plasma-levels-a-retrospective-study-in-a-cohort-of-192-patients-with-prostate-cancer
#4
Giampiero Giovacchini, Elisabetta Giovannini, Elisa Borsò, Patrizia Lazzeri, Mattia Riondato, Rossella Leoncini, Valerio Duce, Maria Picchio, Andrea Ciarmiello
PURPOSE: Several factors have been identified that predict positive fluorine-18-fluoromethylcholine (F-FCH) PET/CT result in patients with prostate cancer undergoing PET/CT for biochemical failure. Among these factors, prostate-specific antigen (PSA) is the single factor most consistently associated with the prediction of positive F-FCH PET/CT. In this study, we wished to confirm this finding and expand it in a large series of patients. PATIENTS AND METHODS: We retrospectively analyzed 192 patients with prostate cancer who were recruited from the Nuclear Medicine Department of the Sant'Andrea Hospital of La Spezia, Italy, from March 2013 to March 2018 and who underwent F-FCH PET/CT owing to biochemical failure after radical prostatectomy...
November 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30507747/classification-of-amyloid-pet-images-using-novel-features-for-early-diagnosis-of-alzheimer-s-disease-and-mild-cognitive-impairment-conversion
#5
Yu Yan, Edward Somer, Vicente Grau
BACKGROUND: New PET tracers could have a substantial impact on the early diagnosis of Alzheimer's disease (AD), particularly if they are accompanied by optimised image analysis and machine learning methods. Fractal dimension (FD) analysis, a measure of shape complexity, has been proven useful in MRI but its application to fluorine-18 amyloid PET has not yet been demonstrated. Shannon entropy (SE) has also been proposed as a measure of image complexity in DTI imaging, but it is not yet widely used in radiology...
November 29, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30489435/discovery-molecular-imaging-digital-ready-pet-ct-performance-evaluation-according-to-the-nema-nu2-2012-standard
#6
Sofia Michopoulou, Emma O'Shaughnessy, Katharine Thomson, Matthew J Guy
OBJECTIVES: The aim of this study was to evaluate and benchmark the performance characteristics of the General Electric (GE) Discovery Molecular Imaging (MI) Digital Ready (DR) PET/CT. MATERIALS AND METHODS: Performance evaluation against the National Electrical Manufacturers Association (NEMA) 2012 standard was performed on three GE Discovery MI DR PET/CT systems installed across different UK centres. The Discovery MI DR performance was compared with the Siemens Biograph mCT Flow, Phillips Ingenuity TF and GE Discovery 690 fully analogue PET/CT systems...
November 27, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30480552/evaluating-the-potential-of-kit-based-68ga-ubiquicidin-formulation-in-diagnosis-of-infection-a-pilot-study68ga
#7
Priya Bhusari, Jyotsna Bhatt, Apurva Sood, Ruchikapreet Kaur, Rakhee Vatsa, Ashu Rastogi, Archana Mukherjee, Ashutosh Dash, Bhagwant Rai Mittal, Jaya Shukla
OBJECTIVE: The aim was to evaluate the diagnostic potential of Ga-ubiquicidin positron-emission tomography/computed tomography (PET/CT) in imaging patients with infection. MATERIALS AND METHODS: Ga-NOTA-ubiquicidin (Ga-UBI) was prepared by addition of freshly eluted Ga-chloride from Ge/Ga generator into the NOTA-ubiquicidin vial and incubated at room for 15 min at 90°C. After compounding of the radiopharmaceutical, quality control using instant thin-layer chromatography, culture and endotoxin estimation was performed...
November 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30461699/quantitative-assessment-of-18f-fdg-pet-in-patients-with-hodgkin-lymphoma-is-it-significantly-affected-by-contrast-enhanced-computed-tomography-attenuation-correction
#8
Conrad-Amadeus Voltin, Jasmin Mettler, Ronald Boellaard, Georg Kuhnert, Markus Dietlein, Peter Borchmann, Alexander Drzezga, Carsten Kobe
OBJECTIVE: The reliability of visual and quantitative response assessment may be impaired owing to inconsistent scanning protocols and image reconstruction methods of 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) PET. Hence, this study investigates the effect of contrast-enhanced computed tomography (CT) attenuation correction in patients with Hodgkin lymphoma. PATIENTS AND METHODS: In 10 consecutive patients undergoing either staging or response assessment, F-FDG PET images were attenuation-corrected once on the basis of unenhanced CT and additionally using contrast-enhanced CT...
November 19, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30461698/influence-of-myocardial-count-on-phase-dyssynchrony-analysis-of-gated-myocardial-perfusion-single-photon-emission-computed-tomography
#9
Akinobu Kita, Masahisa Onoguchi, Takayuki Shibutani, Katsuya Sugimoto, Nobuyuki Kosaka, Toshiki Adachi, Hirohiko Kimura
OBJECTIVES: Drugs and acquisition times for gated myocardial perfusion single-photon emission computed tomography scintigraphy vary depending on the facility. Even if the same examination is performed in the same facility, the acquisition count differs for each examination because factors such as the patient's age, stress protocol of the patient, the biological half-life of the stress agent, and the patient's response are different. We aimed to evaluate the differences in acquisition counts on the effect of left ventricular function and phase analysis indices...
November 19, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30461697/the-synthesis-of-a-new-macromolecule-for-the-sentinel-node-detection-99mtc-gly-mannosyl-dextran
#10
Gang Wang, Erming Wu, Yang Wang, Heyun Huang, Yanfang Zhou, Zhiming Chen
OBJECTIVE: We aimed to design and synthesize a new macromolecule for sentinel node detection to improve the imaging quality and avoid possible adverse effect. BACKGROUND: The imaging of sentinel lymph node has been an important field in the nuclear medicine. A lot of imaging agents have been developed, including Tc-sulfer colloid, Tc-labeled dextrans and the latest Tc-DTPA-mannosyl-dextran. With the technology advanced, the imaging ability of the agents has been better and better...
November 19, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30461696/assessment-of-therapeutic-effects-of-statin-on-cardiac-sympathetic-nerve-activity-and-cardiac-events-in-patients-with-ischemic-cardiomyopathy-and-mild-to-moderate-heart-failure
#11
Shu Kasama, Takuji Toyama, Shota Suzuki, Yukie Ito, Naoya Matsumoto, Masahiko Kurabayashi, Masato Kasahara
INTRODUCTION: We determined whether statin therapy improved cardiac sympathetic nerve activity as evaluated using iodine-123-metaiodobenzylguanidine (I-MIBG) scintigraphy, and whether this therapy affects prognosis in patients with ischemic cardiomyopathy. PATIENTS AND METHODS: This study was a subanalysis of our previous report of the result that the serial I-MIBG scintigraphic studies were the most useful prognostic indicator in patients with heart failure. Patients with heart failure [left ventricular ejection fraction (LVEF) <45%] but no cardiac events for at least 5 months before the study were identified according to their history of decompensated acute heart failure requiring hospitalization...
November 19, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30444749/choline-pet-ct-in-parathyroid-imaging-a-systematic-review
#12
Wouter A M Broos, Friso M van der Zant, Remco J J Knol, Maurits Wondergem
One of the most promising imaging techniques in primary hyperparathyroidism is PET/CT with choline-based tracers. To investigate the current evidence of these tracers in localizing parathyroid adenoma, a systematic review was performed. A comprehensive literature search was carried out and eligible studies were analyzed. Data were extracted, the level of evidence was scored, and performance data were pooled to calculate the weighted detection rate. Eleven articles were included in this study. The pooled detection rate was 97 and 94% on per patient-based and per lesion-based analysis, respectively...
November 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30444748/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-thyroid-nodules-with-indeterminate-cytology-a-prospective-study
#13
Pedro W Rosario, Tiara G Rocha, Maria R Calsolari
BACKGROUND: Up to 20% of thyroid nodules subjected to fine-needle aspiration exhibit indeterminate cytology. The rate of malignancy in these nodules ranges from 10 to 40%. The objective of this prospective study was to evaluate the utility of fluorine-18-fluorodeoxyglucose (F-FDG) PET in nonautonomous thyroid nodules of more than 1 cm whose cytology is indeterminate (Bethesda categories III or IV) and that are not highly suspicious on ultrasonography. PATIENTS AND METHODS: Fifty-nine patients with 63 nodules were studied...
November 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30480555/celiac-ganglia-can-they-be-misinterpreted-on-multimodal-68ga-psma-11-pet-mr
#14
Ewa J Bialek, Bogdan Malkowski
OBJECTIVE: The objective of this study was to investigate the morphologic features and Ga-prostate-specific membrane antigen (PSMA)-11 avidity of celiac ganglia (CG) on multimodal PET/MRI. MATERIALS AND METHODS: Ga-PSMA-11 whole-body PET/MR examinations in 120 patients, referred for staging or follow-up of prostate cancer, were retrospectively reviewed to investigate the radiotracer uptake [maximum standardized uptake value (SUVmax)] and morphologic features (size, shape, location) of CG...
November 14, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30418381/myocardial-perfusion-imaging-detects-mechanical-dyssynchrony-in-left-ventricular-infarcted-and-noninfarcted-areas-early-after-acute-myocardial-infarction-in-a-porcine-model
#15
Feifei Zhang, Yi Tian, Wei Yang, Xiaoliang Shao, Jianfeng Wang, Shengdeng Fan, Xiaoxia Li, Hui Yan, Xiaosong Wang, Yuetao Wang
BACKGROUND: Left ventricular mechanical dyssynchrony (LVMD) is closely associated with left ventricular dysfunction and poor prognosis in patients with acute myocardial infarction (AMI). However, whether mechanical dyssynchrony is present in the noninfarcted areas remains controversial. This research aimed to quantitatively evaluate the global and regional mechanical dyssynchrony early after AMI by phase analysis of single-photon emission computed tomography (SPECT) gated myocardial perfusion imaging (GMPI) and to further explore the related influencing factors...
November 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30418380/diastolic-dysfunction-can-precede-systolic-dysfunction-on-muga-in-cancer-patients-receiving-trastuzumab-based-therapy
#16
Ran Klein, Doaa Nadouri, Erin Osler, Christopher Johnson, Susan Dent, Girish Dwivedi
BACKGROUND: Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is not conclusively established whether diastolic dysfunction (DD) precedes LVEF decrease in patients developing trastuzumab-induced cardiotoxicity (TIC). OBJECTIVE: The aim was to elucidate whether DD precedes LVEF decrease in trastuzumab-treated patients being monitored with radionuclide multigated acquisition for TIC...
November 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30395048/can-suvmax-values-of-ga-68-psma-pet-ct-scan-predict-the-clinically-significant-prostate-cancer
#17
Emre Demirci, Levent Kabasakal, Onur E Şahin, Elife Akgün, Mehmet Hamza Gültekin, Tünkut Doğanca, Mustafa B Tuna, Can Öbek, Mert Kiliç, Tarik Esen, Ali R Kural
PURPOSE: The intensity of prostate-specific membrane antigen (PSMA) expression increases as the tumor grade increases and the uptake of Ga-68-PSMA is higher in high-grade tumors. The aim of the present study was to evaluate the correlation of preoperative tracer uptake of primary tumor to Gleason Score in patients who underwent prostatectomy. PATIENTS AND METHODS: We retrospectively evaluated 141 patients who had Ga-68-PSMA positron emission tomography/computed tomography (PET/CT) imaging and who underwent prostatectomy...
November 2, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30371606/development-and-validation-of-a-full-model-of-a-four-headed-neuroimaging-single-photon-emission-computed-tomography-scanner
#18
Blair A Johnston, Alice Nicol, Alison Bolster, Jamie Wright
OBJECTIVE: The Nucline X-Ring 4R is a four-headed gamma camera dedicated to neuroimaging. In this paper, we describe and validate a GATE (Geant4 Application for Tomographic Emission) model of the Nucline X-Ring 4R. MATERIALS AND METHODS: Images produced during model simulations were compared with those acquired experimentally to confirm the model was an accurate representation of the scanner. The most commonly reported measurements used to validate a GATE model include energy resolution, spatial resolution and sensitivity...
October 26, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30371605/hypoxia-imaging-with-18f-hx4-pet-in-squamous-cell-head-and-neck-cancers-a-pilot-study-for-integration-into-treatment-planning
#19
Helen M Betts, Richard A O'Connor, Judith A Christian, Vidhiya Vinayakamoorthy, Karen Foweraker, Abigail C Pascoe, Alan C Perkins
BACKGROUND: Radical chemoradiotherapy is the primary treatment for head and neck cancers in many hospitals. Tumour hypoxia causes radiotherapy resistance and is an indicator of poor prognosis for patients. Identifying hypoxia to select patients for intensified or hypoxia-modified treatment regimens is therefore of high clinical importance. PATIENTS AND METHODS: We evaluated hypoxia in a group of patients with newly diagnosed squamous cell head and neck cancer using the hypoxia-selective radiotracer [F]HX4...
October 26, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/30362988/performance-of-compressed-sensing-based-iterative-reconstruction-for-single-photon-emission-computed-tomography-from-undersampled-projection-data-a-simulation-study-in-123i-n-%C3%AF-fluoropropyl-2%C3%AE-carbomethoxy-3%C3%AE-4-iodophenyl-nortropane-imaging
#20
Norikazu Matsutomo, Kaoru Fukaya, Takeyuki Hashimoto, Tomoaki Yamamoto, Eisuke Sato
OBJECTIVE: The aim of this study was to investigate the efficacy of compressed sensing (CS)-based iterative reconstruction (CS-IR) from undersampled projection data in I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography (SPECT). MATERIALS AND METHODS: We used the cylinder/sphere and the striatal digital phantom models. The number of projections was set at 120, 90, 60, 40, and 30 projections. SPECT images were reconstructed using filtered back-projection (FBP), maximum likelihood-expectation maximization (ML-EM), and CS-IR...
October 22, 2018: Nuclear Medicine Communications
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