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Nuclear Medicine Communications

Marloes Brinkman, Sander Jentjens, Kitty Boone, Monique Anten, Constance T R M Stumpel, Patty J Nelemans, Marinus J P G van Kroonenburgh
In patients with neurofibromatosis type 1, transformation of neurofibromas into a malignant peripheral nerve sheath tumor (MPNST) is a severe complication of the disease. Fluorine-18-fluorodeoxyglucose PET/computed tomography (PET/CT) is a viable option for detecting malignant tumors in neurofibromatosis type 1 patients. The aim of this review was to assess the diagnostic performance of the most frequently used parameters of PET/CT in detecting MPNST. An extensive computer search was performed using the Cochrane Library, Pubmed, and Medline/Embase databases...
August 13, 2018: Nuclear Medicine Communications
Giulio Serreli, Livia Ruffini, Ornella Ortenzia, Carla Cidda, Chiara Lazzara, Caterina Ghetti
OBJECTIVE: We describe our experience with a dose-tracking software (Radimetrics) that was used to optimize, from a dosimetric point of view, the single-photon emission computed tomography/computed tomography protocols used in myocardial perfusion imaging. PATIENTS AND METHODS: We extracted and assessed the major dosimetric indices as the administered activity, the computed tomography dose index, the dose length product and the size-specific dose estimates for a large sample of patients before and after an optimization process...
August 8, 2018: Nuclear Medicine Communications
Cyrus Ayubcha, Mahdi Zirakchian Zadeh, Mette J Stochkendahl, Abdullah Al-Zagha, Jan Hartvigsen, Chamith S Rajapakse, William Raynor, Thomas Werner, Anders Thomassen, Hongming Zhuang, Poul F Høilund-Carlsen, Abass Alavi
OBJECTIVE: The aim of this study was to describe osseous metabolic activity with respect to age and weight in the spine as expressed through fluorine-18-sodium fluoride (F-NaF) uptake in a healthy male population. PARTICIPANTS AND METHODS: Whole-body F-NaF PET/CT scans of healthy male participants (22-71 years, 50-145 kg, n=47) were analysed using a global assessment methodology to derive the mean standardized uptake values (SUVmean). Individual regions of the spine (cervical, thoracic and lumbar) along with the aggregate whole spine were assessed and compared as potential functions of age and body weight...
August 6, 2018: Nuclear Medicine Communications
Bulent Yazici, Ipek K Bulut, Aylin Oral, Taylan O Sezer, Sevgin Taner, Aysegül Akgün
OBJECTIVES: The value of baseline renal transplant scintigraphy (RTS) with technetium-99m diethylenetriaminepentaacetic acid (Tc-DTPA) performed within 2 days after transplantation in predicting early renal transplant outcome in pediatric recipients was assessed in this study. PATIENTS AND METHODS: Baseline RTS of 48 pediatric patients were studied retrospectively. Hilson's perfusion index, graft index (GI), time between peak perfusion and iliac artery (ΔP), and the ratios of peak perfusion to plateau (P : Pl), to peak iliac artery (P : A), and to peak uptake (P : U) were obtained...
August 6, 2018: Nuclear Medicine Communications
Anupriya Chhabra, Yogesh Rathore, Priya Bhusari, Rakhee Vatsa, Bhagwant R Mittal, Jaya Shukla
Rhenium-188 (Re) is a β, γ emitter and considered a theranostic radionuclide. It is used for bone pain palliation, treatment of unresectable hepatocellular carcinoma, skin keloids, etc. Re perrhenate is eluted from a W/Re generator in large volumes (8-14 ml) of 0.9% normal saline. Concentrating Re to 1-2 ml volume is important for high radiolabelling yield of various Re radiopharmaceuticals, especially when the generator is old. For this, ion exchange column was prepared in-house, and Re was concentrated using silver ion exchange column and QMA cartridge...
August 6, 2018: Nuclear Medicine Communications
Daniel H Kim, Huub Wit, Mark Thurston
OBJECTIVE: The objective of this study was to identify the extent to which artificial intelligence could be used in the diagnosis of Parkinson's disease from ioflupane-123 (I) single-photon emission computed tomography (SPECT) dopamine transporter scans using transfer learning. MATERIALS AND METHODS: A data set of 54 normal and 54 abnormal I SPECT scans was amplified 44-fold using a process of image augmentation. This resulted in a training set of 2376 normal and 2376 abnormal images...
August 3, 2018: Nuclear Medicine Communications
Su-Faye Lee, Meir Lichtenstein, Peter Hughes, Dinesh Sivaratnam
OBJECTIVE: Major complications including acute tubular necrosis or rejection may occur after renal transplantation. We use a semiquantitative parameter, 2 min uptake (2MU), as part of Tc mercaptoacetyltriglycine (MAG3) scintigraphy for transplant evaluation. The aim of this study were (a) to examine the utility of Tc MAG3 scintigraphy in the assessment of postsurgical complications using the renal biopsy as the gold standard and (b) examine for any correlation with 2MU with serum creatinine (sCr) at 3 and 12 months...
August 1, 2018: Nuclear Medicine Communications
Sofiullah Abubakar, Donovan Jacobs, Tessa Kotze
PURPOSE: There are conflicting results from studies on whether ventilation scintigraphy can be safely omitted or replaced by chest radiography. These studies were based on planar ventilation/perfusion (V/Q) scintigraphy. We evaluated the value of the ventilation single-photon emission computed tomography (SPECT) on the final conclusion drawn from a V/Q SPECT and the possible role of the chest radiography as a surrogate for the ventilation SPECT. PATIENTS AND METHODS: Raw data of V/Q SPECT images and chest radiography acquired within 48 h over an 18-month period were retrieved, reprocessed and reviewed in batches...
July 25, 2018: Nuclear Medicine Communications
Alp Notghi, Shazmeen Hansrod
AIM: This study was undertaken to investigate the extent of variation in meals, radiopharmaceuticals and methodology used for gastric emptying studies in the UK. MATERIALS AND METHODS: Overall, 178 nuclear medicine departments across the UK were contacted by telephone and the gastric emptying protocol was requested. In all, 128 (72%) performed routine gastric emptying studies; 83 protocols were received. RESULTS: Liquid meal gastric emptying: 15 departments performed liquid gastric emptying either as a dual isotope technique (27%) or as a separate test using Tc-diethylenetriamine pentacetic acid (53%) or Tc-colloid (20%)...
July 23, 2018: Nuclear Medicine Communications
Pragati Jha, Geetanjali Arora, Shamim A Shamim, Anirban Mukherjee, Deepak Gautam, Sanjana Ballal, Uma Kumar, Tahir M Ansari, Chandrasekhar Bal
OBJECTIVE: To evaluate the treatment response of lutetium-177 tin colloid radiosynovectomy (Lu-RSV) in patients with inflammatory knee joint conditions refractory to conventional treatment. PATIENTS AND METHODS: Overall, 29 knee joints in 29 patients with chronic synovitis caused by various inflammatory knee joint diseases refractory to conventional therapy were included in this prospective study. All patients were assessed clinically for pain, tenderness, joint swelling, mobility, analgesic intake, and blood pool activity on bone scan...
July 9, 2018: Nuclear Medicine Communications
Kei Wagatsuma, Keiichi Oda, Muneyuki Sakata, Motoki Inaji, Kenta Miwa, Masayuki Sasaki, Jun Toyohara, Kenji Ishii
OBJECTIVE: High levels of radioactivity inside a facemask cause scatter correction (SC) errors that appear as photopenic artifacts on quantitative oxygen-15 (O) gas-inhalation positron emission tomography (PET) images. The present study aimed to validate the ability of scatter limitation correction (SLC) to eliminate SC errors in O gas-inhalation PET images acquired from patients and a phantom. MATERIALS AND METHODS: We analyzed the SC errors in phantom images and calculated parametric images of the cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2)...
July 6, 2018: Nuclear Medicine Communications
Jonathan Vigne, Stéphane Emery, Nicolas Lemarie, Bénédicte Chavent, François Hallouard, Dominique Le Guludec, François Rouzet, Marc Fraysse, Rémy De Mil
Fractionated elution consists in collecting the fractions of an eluate with the highest radioactive concentration. It may be useful to meet the requirements of a subset of clinical radiopharmacy procedures. This study aims to describe and evaluate straightforward procedures allowing to readily perform fractionated elution on dry and wet columns Mo/Tc generators by using calibrated vials. The main objectives of this study consisted in determining the relationship between eluate volume and elution yield using different vials calibration and assessing repeatability of the procedure...
July 2, 2018: Nuclear Medicine Communications
Salam Mohammadinia, Seyed M Abedi, Zohreh Noaparast
BACKGROUND: The intense liver uptake of technetium-99-sestamibi (Tc-MIBI) and photon scattering from the liver cause problems in quantitative perfusion interpretation. Hence, Tc-MIBI is a substrate for P-glycoprotein pump; variations in P-glycoprotein levels may affect liver clearance. METHODS AND RESULTS: Adult female Wistar rats were divided into seven main groups [control and St. John's Wort (SJW) treated] and each SJW-treated group included three subgroups that were killed at 15, 30, and 45 min after Tc-MIBI injection...
June 26, 2018: Nuclear Medicine Communications
Abhishek Chatterjee, Tejpal Gupta, Venkatesh Rangarajan, Nilendu Purandare, Shreya Kunder, Vedang Murthy, Ashwini Budrukkar, Sarbani Ghosh-Laskar, JaiPrakash Agarwal
OBJECTIVES: The aim of this study was to identify the optimal timing of fluorine-18-fluoromisonidazole (F-MISO) PET/CT imaging to assess hypoxia in patients with head and neck squamous cell carcinoma. PATIENTS AND METHODS: Eighteen patients underwent pretreatment F-MISO PET/CT imaging after providing written informed consent. PET scans were acquired at 1, 3, and 5 h after injection of the radionuclide. The mean standardized uptake value (SUV) within a spherical region of interest placed on the contralateral neck musculature at the level of the largest tumor dimension was labeled as background...
June 22, 2018: Nuclear Medicine Communications
Ning-Hu Liu, Meng-Jie Dong, Hao Liu, Xi-Li Lu, Dan Tian, Jun Zhang, Jun Yang, Jun-Hui Sun, Li-Hua Wu, Jian-Li Bi, Bo Zhang
OBJECTIVE: The aim was to perform exploratory research on the application of technetium phytate (Tc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity. PATIENTS AND METHODS: A total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child-Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system...
June 19, 2018: Nuclear Medicine Communications
Luca Filippi, Giovan G Di Costanzo, Antonio D'Agostini, Raffaella Tortora, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci, Oreste Bagni
PURPOSE: This study aims to evaluate the prognostic role of the decrease in total lesion glycolysis (TLG) assessed by fluorine-18-fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) 1 month after yttrium-90-radioembolization (Y-RE) in patients affected by hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). PATIENTS AND METHODS: Twenty-one patients with histologically proven poorly differentiated HCC and evidence of PVTT at the enhanced multislice CT underwent Y-RE...
June 12, 2018: Nuclear Medicine Communications
Nathan J Dickinson, Charnie Kalirai, Richard A O'Connor, Karen Mullin
AIM: The aim of this study was to examine the agreement of pretreatment Tc-macroaggregated albumin imaging performed for selective internal radiation therapy (SIRT) workup with Y percentage lung shunt (PLS) and regional hepatic distribution in subsequent post-therapy bremsstrahlung imaging. PATIENTS AND METHODS: Planar images were used to calculate PLS. The significant Y bremsstrahlung scatter required background correction. Results using both Y lung background regions of interest (ROI) reported in previous studies and extended ROIs (reflecting lung background variation) were compared with Tc-MAA PLS...
June 6, 2018: Nuclear Medicine Communications
Mavin Macauley, Mohamed Shawgi, Tamir Ali, Andrew Curry, Kim Howe, Elizabeth Howell, Elizabeth Jefferson, Andrew James, Petros Perros, George S Petrides
OBJECTIVE: This study aims to explore the normal reference values for thyroid uptake of technetium-99m (Tc) pertechnetate in a UK population. PATIENTS AND METHODS: A retrospective review of 60 euthyroid patients who underwent thyroid imaging with Tc pertechnetate between January 2012 to April 2014 as part of dual-tracer subtraction parathyroid scintigraphy. Tc pertechnetate thyroid uptake values were determined for each patient. Medical records and biochemical thyroid function tests were reviewed to ensure that all patients were not on medication that could affect thyroid function and they were both clinically and biochemically euthyroid 6 months before and following the scan...
June 6, 2018: Nuclear Medicine Communications
Asuka Mizutani, Masato Kobayashi, Ken-Ichi Fujita, Kotaro Takahashi, Tsuzumi Hokama, Hiroaki Takasu, Kodai Nishi, Ryuichi Nishii, Naoto Shikano, Kazuki Fukuchi, Keiichi Kawai
OBJECTIVES: Drugs are mainly metabolized by hepatic enzymes, the activity of which can differ between individuals. Although it is ideal to measure the hepatic clearance of liver-targeted drugs in individualized medicine, blood enzyme tests typically measure metabolic drug clearance in the entire body, and not just in the liver. We investigated whether I-iomazenil imaging can directly assess and quantify the activity of hepatic drug-metabolizing enzymes. MATERIALS AND METHODS: Hepatic enzymes that metabolize I-iomazenil were identified by thin-layer chromatography in mouse liver homogenates with bis(4-nitrophenyl) phosphate (BNPP) inhibitor for carboxylesterase enzymes and nicotinamide adenine dinucleotide phosphate (NADPH) generator for cytochrome P450 enzymes...
June 5, 2018: Nuclear Medicine Communications
Mariana Corneli, Osvaldo Masoli, Gabriel Perea, Alejandro Meretta, Gustavo Daquarti, Daniel Rosa, Fernando Belcastro, Ruth Henquin, Néstor Perez Baliño
The present study provides actual data with regard to the prevalence of myocardial ischemia among patients under contemporary cardiovascular prevention strategies undergoing peripheral vascular interventions. We included a total of 200 consecutive patients who underwent gated single-photon emission computed tomography myocardial perfusion study between January 2012 and January 2014 as preoperative evaluation for peripheral vascular interventions at our institution. The baseline medical treatment comprised aspirin (81%), statins (79%), and β-blockers (54%)...
September 2018: Nuclear Medicine Communications
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