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Nuclear Medicine Communications

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https://www.readbyqxmd.com/read/28196002/news-and-views-march-2017
#1
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28187040/infushield-a-shielded-enclosure-for-administering-therapeutic-radioisotope-treatments-using-standard-syringe-pumps
#2
Dominic P Rushforth, Brenda E Pratt, Sarah J Chittenden, Iain S Murray, Louise Causer, Matthew J Grey, Jonathan I Gear, Yong Du, Glenn D Flux
The administration of radionuclide therapies presents significant radiation protection challenges. The aim of this work was to develop a delivery system for intravenous radioisotope therapies to substantially moderate radiation exposures to staff and operators. A novel device (InfuShield) was designed and tested before being used clinically. The device consists of a shielded enclosure which contains the therapeutic activity and, through the hydraulic action of back-to-back syringes, allows the activity to be administered using a syringe pump external to the enclosure...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28145970/importance-of-accurate-ilio-inguinal-quantification-in-lower-extremity-lymphoscintigraphy
#3
Georgia Keramida, Nicola Winterman, Emma Wroe, Mark Aplin, A Michael Peters
AIMS: The aims of this study were to improve the quantification of lower extremity lymphoscintigraphy, determine its value and lower limit of normal, and determine whether intermediate postinjection time imaging is necessary. PATIENTS AND METHODS: This was a study of 102 consecutive patients undergoing routine lower extremity lymphoscintigraphy using subcutaneous Tc-99m-nanocolloid with imaging at 5, 45 and 150 min after injection. Abnormal imaging criteria were delay (no activity in ilio-inguinal nodes at 45 min or negligible activity at 150 min), lymph diversion (through skin or deep system) and focal accumulation suggesting cellulitis...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28118260/effect-of-different-segmentation-algorithms-on-metabolic-tumor-volume-measured-on-18f-fdg-pet-ct-of-cervical-primary-squamous-cell-carcinoma
#4
Weina Xu, Shupeng Yu, Ying Ma, Changping Liu, Jun Xin
BACKGROUND AND PURPOSE: It is known that fluorine-18 fluorodeoxyglucose PET/computed tomography (CT) segmentation algorithms have an impact on the metabolic tumor volume (MTV). This leads to some uncertainties in PET/CT guidance of tumor radiotherapy. The aim of this study was to investigate the effect of segmentation algorithms on the PET/CT-based MTV and their correlations with the gross tumor volumes (GTVs) of cervical primary squamous cell carcinoma. MATERIALS AND METHODS: Fifty-five patients with International Federation of Gynecology and Obstetrics stage Ia∼IIb and histologically proven cervical squamous cell carcinoma were enrolled...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28099265/observer-agreement-of-treatment-responses-on-planar-bone-scintigraphy-in-prostate-cancer-patients-importance-of-the-lesion-assessment-method
#5
Randi F Fonager, Helle D Zacho, Signe Albertsen, Joan Fledelius, June A Ejlersen, Mette H Christensen, Ramune Aleksyniene, José A Biurrun Manresa, Lars J Petersen
PURPOSE: The aim of this study was to assess observer agreement on the evaluation of treatment responses of bone metastases by bone scintigraphy (BS) using different scoring methods in prostate cancer patients. PATIENTS AND METHODS: Sixty-three paired BS from 55 patients were included. BS was performed before and after more than 12 weeks of anticancer treatment. A panel of experienced nuclear medicine physicians from several institutions evaluated treatment response using three different methods: (a) standard clinical assessment, (b) MD Anderson criteria, and (c) Prostate Cancer Working Group 2 (PCWG-2) criteria...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28099264/post-treatment-18f-fdg-pet-ct-versus-contrast-enhanced-ct-in-patients-with-oropharyngeal-squamous-cell-carcinoma-comparative-effectiveness-study
#6
Mehdi Taghipour, Esther Mena, Matthew J Kruse, Sara Sheikhbahaei, Rathan M Subramaniam
OBJECTIVE: To compare the accuracy of same-day therapy-assessment PET/computed tomography (PET/CT) and conventional contrast-enhanced computed tomography (CECT) in patients with oropharyngeal squamous cell carcinoma (OPSCC). METHODS: A total of 110 (95 men and 15 women; mean age 59 years) patients with biopsy-proven OPSCC were evaluated with same-day PET/CT and CECT pair scans as part of follow-up therapy assessment. Scans were performed within 6 months after the completion of primary treatment (median time: 3...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28067689/eight-years-of-growth-and-change-in-uk-molecular-radiotherapy-with-implications-for-the-future-internal-dosimetry-users-group-survey-results-from-2007-to-2015
#7
Bruno Rojas, Claire Hooker, Daniel R McGowan, Matthew J Guy, Jill Tipping
No abstract text is available yet for this article.
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28009777/the-cardiosplenic-axis-another-obscure-pathophysiological-function-of-the-spleen-and-its-investigation-using-molecular-imaging
#8
Alexander Dunford, Georgia Keramida, Constantinos D Anagnostopoulos, A Michael Peters
Splenic pathophysiology has been relatively unstudied, but recently, the spleen has received more attention as a result of the discovery of the 'cardiosplenic axis'. This term describes a role that the spleen plays in the progression of atherosclerosis following acute myocardial infarction. Human studies of this axis have largely used fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT to quantify peri-infarction inflammation, arterial wall inflammation and splenic metabolic activity. Most of these studies have quantified arterial wall inflammation and splenic metabolic activity using the standardized uptake value, but this is a semiquantitative measurement with several drawbacks, including overestimation of metabolic activity in overweight individuals and a dependence on blood glucose levels...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28002173/higher-preablative-serum-thyroid-stimulating-hormone-level-predicts-radioiodine-ablation-effectiveness-in-patients-with-differentiated-thyroid-carcinoma
#9
Ismaheel O Lawal, Nozipho E Nyakale, Lerwine M Harry, Thabo Lengana, Neo P Mokgoro, Mariza Vorster, Mike M Sathekge
INTRODUCTION: Radioiodine ablation of remnant thyroid tissue is an important adjuvant therapy of differentiated thyroid carcinoma (DTC) after thyroidectomy. Elevated serum thyroid-stimulating hormone (TSH) level is necessary for successful ablation. The optimum level of serum TSH level necessary for successful radioiodine ablation of well-DTC is, however, yet to be defined. We aimed to determine whether higher serum TSH level will result in a better rate of complete ablation of well-DTC using iodine-131 (I) following initial thyroidectomy...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27984539/validation-of-an-electronic-image-reader-training-programme-for-interpretation-of-18f-flutemetamol-%C3%AE-amyloid-pet-brain-images
#10
Christopher J Buckley, Paul F Sherwin, Adrian P L Smith, Jan Wolber, Sharon M Weick, David J Brooks
OBJECTIVES: An electronic training programme (ETP) was developed for interpretation of images during routine clinical use of the PET amyloid imaging agent [F]flutemetamol injection (VIZAMYL). This study was carried out to validate the ETP. MATERIALS AND METHODS: Five nuclear medicine technologists (NMTs) and five readers previously inexperienced in amyloid image interpretation were required to self-train using the ETP and pass a test to participate. A total of 305 [F]flutemetamol PET images were then tested as the validation set, following preassessment and reorientation (where required) by one of five NMTs...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27984538/clinical-outcomes-of-low-dose-and-high-dose-postoperative-radioiodine-therapy-in-patients-with-intermediate-risk-differentiated-thyroid-cancer
#11
Ju Hye Jeong, Eun Jung Kong, Shin Young Jeong, Sang-Woo Lee, Ihn Ho Cho, Kyung Ah Chun, Jaetae Lee, Byeong-Cheol Ahn
PURPOSE: Recent studies have suggested that a low dose (LD) of radioiodine (RAI) is sufficient to treat differentiated thyroid cancer (DTC) even in patients with intermediate risk. However, these studies evaluated the efficacy of RAI therapy, irrespective of the results of the whole-body scan (WBS). The aim of the present study was to evaluate the response to LD and high-dose (HD) RAI therapy using two different criteria (with and without WBS results) and the reclassification system according to the revised 2015 guidelines of the American Thyroid Association in Korean intermediate-risk DTC patients...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27984537/18f-fcho-pet-and-mri-for-the-prediction-of-response-in-glioblastoma-patients-according-to-the-rano-criteria
#12
Julie Bolcaen, Marjan Acou, Tom Boterberg, Christian Vanhove, Filip De Vos, Caroline Van den Broecke, Roel Van Holen, Karel Deblaere, Ingeborg Goethals
PURPOSE: In this study, we investigated fluorine-18 fluoromethylcholine (F-FCho) PET and contrast-enhanced MRI for predicting therapy response in glioblastoma (GB) patients according to the Response Assessment in Neuro-Oncology criteria. Our second aim was to investigate which imaging modality enabled prediction of treatment response first. MATERIALS AND METHODS: Eleven GB patients who underwent no surgery or debulking only and received concomitant radiation therapy (RT) and temozolomide were included...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27977537/pretreatment-metabolic-parameters-measured-by-18f-fdg-pet-to-predict-the-outcome-of-first-line-chemotherapy-in-extensive-stage-small-cell-lung-cancer
#13
Xiaozhou Yu, Yanjia Zhu, Jian Wang, Xiuyu Song, Lei Zhu, Xiaoyuan Men, Xiaofeng Li, Dong Dai, Wengui Xu
OBJECTIVE: Patients' pretreatment metabolic burden, as measured by radiotracer fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT), has been shown to predict treatment outcome in various malignancies. However, its predictive role in extensive-stage small cell lung cancer (SCLC) has not been definitively determined. This retrospective study investigated the viability of using common pretreatment metabolic parameters, obtained through F-FDG-PET/CT, to predict outcomes of first-line chemotherapy in extensive-stage SCLC...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27977536/incidence-of-a-single-subsegmental-mismatched-perfusion-defect-in-single-photon-emission-computed-tomography-and-planar-ventilation-perfusion-scans
#14
Matthew Stubbs, Kenneth Chan, Helena McMeekin, Shaunak Navalkissoor, Thomas Wagner
OBJECTIVE: This study aims to compare the incidence of ventilation/perfusion (V/Q) scans interpreted as indeterminate for the diagnosis of pulmonary embolism (PE) using single-photon emission computed tomography (SPECT) versus planar scintigraphy and to consider the effect of variable interpretation of single subsegmental V/Q mismatch (SSM). METHODS: A total of 1300 consecutive V/Q scans were retrospectively reviewed. After exclusion and matching for age and sex, 542 SPECT and 589 planar scans were included in the analysis...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27977535/the-ideal-dual-isotope-imaging-combination-in-evaluating-patients-with-suspected-infection-of-pelvic-pressure-ulcers
#15
Sherif I Heiba, Lewen Stempler, Timothy Sullivan, Dov Kolker, Lale Kostakoglu
INTRODUCTION: The successful management of infected pelvic pressure ulcer patients (PPUP) depends on the distinction between infections limited to soft tissue (STI) and those with underlying osteomyelitis (OM), which can be difficult to determine clinically. Dual-isotope (DI) comprehensive imaging has excellent accuracy in localizing diabetic foot infection and differentiating OM from STI with SPECT/CT utilization. In this study, we assess the accuracy and confidence of the different DI SPECT/CT imaging steps in PPUP with confirmed diagnoses...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27922540/prognostic-value-of-quantitative-pet-ct-in-patients-with-a-nonsmall-cell-lung-cancer-and-another-primary-cancer
#16
Xuee Zhu, Chuanhong Liao, Bill C Penney, Feng Li, Mark K Ferguson, Cassie A Simon, Tianming Wu, Haiyan Liu, Yonglin Pu
OBJECTIVE: The staging and management of patients with newly diagnosed nonsmall cell lung cancer (NSCLC) in the setting of recently diagnosed other (metachronous or synchronous) primary cancer are challenging. This retrospective cohort study was carried out to test our hypothesis that baseline 2-deoxy-2-[F]fluoro-D-glucose (F-FDG) PET/CT parameters, including whole-body metabolic tumor volume (MTVWB), total lesion glycolysis (TLGWB), and maximum standardized uptake value (SUVmaxWB), are associated with the overall survival (OS) of such patients...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27922539/effect-of-tomographic-operator-inaccuracies-and-respiratory-motion-on-pet-ct-lung-nodule-images-smearing
#17
Joël Daouk, Pascal Bailly, Roger Bouzerar, Marc-Étienne Meyer
BACKGROUND: In thoracic PET/computed tomography (CT) imaging, uptake foci usually appear smeared because of postreconstruction smoothing and respiratory motion. OBJECTIVE: The aim of the present study was to assess the respective contributions of the reconstruction process and respiratory motion on PET/CT images. MATERIALS AND METHODS: Thirty-one pulmonary lesions were studied. Free-breathing PET/CT acquisitions were followed by a 10-min respiratory-gated PET/CT acquisition...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27922538/the-role-of-68ga-dota-noc-pet-ct-in-evaluating-neuroendocrine-tumors-real-world-experience-from-two-large-neuroendocrine-tumor-centers
#18
Mohamad Haidar, Ali Shamseddine, Emmanouil Panagiotidis, Mario Jreige, Deborah Mukherji, Rita Assi, Rayan Abousaid, Toni Ibrahim, Marwan M Haddad, Sobhan Vinjamuri
OBJECTIVE: Our aim was to assess the role of Ga-DOTA-NOC PET/CT as a tool for the management of neuroendocrine tumors (NETs), evaluating the clinical impact on patients from two large NET centers in different geopolitical settings. PATIENTS AND METHODS: This is a retrospective study of patients with NETs who underwent Ga-DOTA-NOC PET/CT at Royal Liverpool University Hospital (UK) and at Mount Lebanon Hospital (Lebanon). Indications for imaging and findings of the PET/CT along with demographic and clinical outcome data were recorded and evaluated...
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27906780/developing-a-dedicated-comprehensive-%C3%AE-radionuclide-therapy-program-should-this-be-the-vision-of-the-atomic-energy-programs-in-the-next-decade
#19
Sandip Basu, Sharmila Banerjee
No abstract text is available yet for this article.
February 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27893589/the-role-of-psma-pet-ct-imaging-in-restaging-of-prostate-cancer-patients-with-low-prostate-specific-antigen-levels
#20
Levent Kabasakal, Emre Demirci, Jamal Nematyazar, Reşit Akyel, Baresh Razavi, Meltem Ocak, Aslan Aygun, Can Obek, Ali R Kural
INTRODUCTION: Prostate-specific membrane antigen (PSMA) is increasingly being recognized as a novel target for the PET imaging of prostate cancer (PCa) and Ga-DKFZ-11 (Ga-PSMA) has been suggested as a novel tracer for detection of PCa relapses and metastases. The aim of this study was to evaluate the diagnostic value of PSMA PET/CT in the diagnosis of recurrent PCa with low prostate-specific antigen (PSA) levels. PATIENTS AND METHODS: We carried out a retrospective analysis of patients who underwent PSMA PET/CT from November 2013 to December 2014 in our department...
February 2017: Nuclear Medicine Communications
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