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Nuclear Medicine Communications

Joyce C Mhlanga, Alin Chirindel, Martin A Lodge, Richard L Wahl, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to determine whether various fluorine-18-fluorodeoxyglucose PET/CT-derived parameters used in oncology vary significantly depending on the interpretation software systems used in clinical practice for multiple human solid tumors. PATIENTS AND METHODS: A total of 120 fluorine-18-fluorodeoxyglucose PET/CT studies carried out in patients with pancreatic, lung, colorectal, and head and neck cancers were evaluated retrospectively on two different vendor software platforms including Mirada and MIMVista...
December 8, 2017: Nuclear Medicine Communications
Tima Davidson, Orna Komisar, Jacob Korach, Shira Felder, Sara Apter, Simona Ben-Haim, Tamar Perri
BACKGROUND: Ovarian transposition is aimed at preserving ovarian function before irradiation in pelvic malignancies. The extrapelvic location of the ovaries and their physiologic fluorine-18-fluorodeoxyglucose (F-FDG)-uptake is a potential source of misdiagnosis as metastasis on F-FDG PET/CT. We describe the F-FDG PET/CT characteristics of transposed ovaries and their changes over time. PATIENTS AND METHODS: We reviewed F-FDG PET/CT studies of all consecutive women with pelvic malignancies who underwent ovarian transposition between 2007 and 2013...
December 5, 2017: Nuclear Medicine Communications
Christophe Hedon, Fabien Huet, Fayçal Ben Bouallegue, Hélène Vernhet, Jean-Christophe Macia, Thien-Tri Cung, Florence Leclercq, Stéphane Cade, Frédéric Cransac, Benoit Lattuca, D'Arcy Vandenberghe, Aurélie Bourdon, Meriem Benkiran, Fabien Vauchot, Richard Gervasoni, Emmanuel D'estanque, Denis Mariano-Goulart, François Roubille
BACKGROUND: Myocardial salvage is an important surrogate endpoint to estimate the impact of treatments in patients with ST-segment elevation myocardial infarction (STEMI). AIM: The aim of this study was to evaluate the correlation between cardiac sympathetic denervation area assessed by single-photon emission computed tomography (SPECT) using iodine-123-meta-iodobenzylguanidine (I-MIBG) and myocardial area at risk (AAR) assessed by cardiac magnetic resonance (CMR) (gold standard)...
November 29, 2017: Nuclear Medicine Communications
Murat Sadic, Koray Demirel, Sevil O Halacli, Emre Karakok, Gokhan Koca, Ozgur Ekinci, Kadir Demircan, Meliha Korkmaz
OBJECTIVE: The aim of this study was to investigate the presence of ADAMTS2 and ADAMTS5 in the salivary gland (SG) of rats after high-dose radioiodine therapy. METHODS: A total of 36 male Wistar albino rats were used for this study. Thirty-six male rats were divided randomly into six groups: control and five radioactive iodine (RAI) treatment groups of six rats each. All animals were killed. The evaluation of biodistribution and histopathological studies were carried out on the SGs removed...
November 29, 2017: Nuclear Medicine Communications
Ziqi Zhou, Xiaoliang Liu, Ke Hu, Fuquan Zhang
The aim of this study was to evaluate the clinical value of PET and PET/CT in suspected recurrent cervical cancer. The recurrence of cervical cancer has a poor prognosis. Earlier intervention would lead to a better prognosis. PET and PET/CT were promising in early diagnosis of recurrence because they could detect the biological and molecular changes before the anatomical size changes occurred. However, few data concerning the clinical effect of PET and PET/CT were available. The database for PET (or positron emission tomography or FDG or fluorodeoxyglucose) AND cervical cancer (or cervical tumor or cervical neoplasm or cervical carcinoma) AND recurrence or relapse was searched...
November 20, 2017: Nuclear Medicine Communications
Renjith K Radhakrishnan, Bhagwant R Mittal, Rajender K Basher, Gaurav Prakash, Pankaj Malhotra, Naveen Kalra, Ashim Das
PURPOSE: The aim of this study was to analyse the positive predictive value (PPV) of post-therapy fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT performed for response or recurrence evaluation in patients with non-Hodgkin's lymphoma (NHL) and to appraise the diagnostic utility of F-FDG PET/CT-guided biopsy in this setting. PATIENTS AND METHODS: A total of 17 patients with NHL showing F-FDG avid lesions in F-FDG PET/CT performed for response or recurrence assessment underwent F-FDG PET/CT-guided biopsy using automated robotic biopsy arm needle navigation technique...
November 20, 2017: Nuclear Medicine Communications
Nazmus Sakib, Na Li, Xiaoxia Zhu, Dianhe Li, Yiyi Li, Haofei Wang
BACKGROUND: In a previous meta-analysis-based modeling study, it was hypothesized that modern postoperative radiotherapy (PORT) may improve both local recurrence and overall survival (OS) in stage IIIA-N2 non-small-cell lung cancer (NSCLC). There were only four single-arm trials with a total of 357 patients. As other trials have provided new and controversial data, we performed this updated meta-analysis to test the hypothesis. PATIENTS AND METHODS: Systematic reviews in Medline, Cochrane, and Science Direct up to December 2015 identified publications exploring the efficacy of PORT in resectable stage IIIA-N2 NSCLC...
November 20, 2017: Nuclear Medicine Communications
Brenda E Pratt, Cecilia Hindorf, Sarah J Chittenden, Christopher C Parker, Glenn D Flux
OBJECTIVE: The aim of the study was to determine the fraction of administered activity that was excreted and retained by a small cohort of patients who each received treatment with radium-223 dichloride (Ra). Ra is an α-emitting radionuclide that has been approved for use in the treatment of bone metastases that are secondary to castration resistant prostate cancer. PATIENTS AND METHODS: Six patients received two weight-based administrations of Ra 6 weeks apart...
November 17, 2017: Nuclear Medicine Communications
Heather R Webb, Hamid R Latifi, Landis K Griffeth
OBJECTIVE: The aim of this study was to assess the added benefit of whole-body (head-to-toes) PET/CT versus routine 'eyes-to-thighs' PET/CT of melanoma and sarcoma patients. PATIENTS AND METHODS: We performed a retrospective review of consecutive whole-body PET/CT scans from January 2006 through December 2010 in patients with melanoma or sarcoma. PET abnormalities in the brain, distal thighs, and legs were recorded and clinical significance was assessed on the basis of pathology, imaging studies, and clinical follow-up...
November 17, 2017: Nuclear Medicine Communications
Maoqing Jiang, Ping Chen, Xinzhong Ruan, Weiling Xu, Tianfu Li, Liyun Wu, Wenlan Zhou, Hubing Wu, Quanshi Wang
OBJECTIVE: In this study, we investigated the prognostic role of interim fluorine-18-fluorodeoxyglucose PET/computed tomography (I-PET/CT) and BCL2 in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab-containing chemotherapy. MATERIALS AND METHODS: A total of 106 patients with newly diagnosed DLBCL underwent PET/CT scans at baseline and a subsequent I-PET/CT after the fourth cycle of chemotherapy. I-PET/CT was analyzed using the Deauville five-point score...
November 17, 2017: Nuclear Medicine Communications
Gul Ege Aktas, Ebru Taştekin, Ali Sarikaya
OBJECTIVE: The aim of this study was to evaluate the relationship of baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for the primary tumor with clinicopathological risk factors and molecular subtypes in patients with invasive ductal breast carcinoma (IDBC). PATIENTS AND METHODS: We evaluated 65 patients who underwent fluorine-18-fluorodeoxyglucose PET/CT for initial breast cancer staging. The association of maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis (TLG) with clinicopathological risk factors and molecular subtypes was investigated and the discriminative power of significant features was assessed...
November 10, 2017: Nuclear Medicine Communications
Xinyu Wu, Hao Gu, Yongju Gao, Bo Li, Ruitai Fan
OBJECTIVE: A total of 118 patients with papillary thyroid carcinoma treated with radioactive iodine for lymph node metastases were analyzed retrospectively between August 2008 and June 2014. We describe the clinical course of these patients and focus on factors associated with lymph node metastases response to iodine-131 (I) treatment. PATIENTS AND METHODS: A total of 118 postoperative papillary thyroid carcinoma patients who underwent I treatment with lymph nodes as the only site of metastasis on whole-body scan (I Rx-WBS) and single-photon emission computed tomography-computed tomography (SPECT-CT) were enrolled...
November 10, 2017: Nuclear Medicine Communications
Koichi Yano, Kazuhiro Kondo, Atsushi Nanashima, Yoshiro Fujii, Naoya Imamura, Masahide Hiyoshi, Takeomi Hamada, Yuki Tsuchimochi, Takashi Wada, Yoichi Mizutani, Toshinori Hirai
BACKGROUND: Prognosis in patients with hepatocellular carcinoma (HCC) is not only influenced by tumor-related factors but also by the background liver functions. The maximal removal rate of technetium-99m-galactosyl human serum albumin (GSA-Rmax) of the remnant liver (rGSA-Rmax) is a useful candidate for predicting the liver function and clarifying the relationship between the remnant liver functional reserve and tumor-free survival in patients who have undergone hepatectomy. PATIENTS AND METHODS: One hundred and sixty-five patients with HCC who underwent curative hepatectomy were divided into three groups of hepatitis B virus (B-HCC; n=42), hepatitis C virus (C-HCC, n=58), and non-B, non-C (NBNC-HCC, n=65)...
November 2, 2017: Nuclear Medicine Communications
Simin Razavi, Blair Ziebarth, Ran Klein, Wanzhen Zeng
OBJECTIVES: Dual-phase parathyroid scan with Tc-sestamibi is a standardized imaging method for diagnosing parathyroid adenoma and hyperplasia. Conventional planar images using a gamma camera are performed routinely in early and delayed time points, followed by a single SPECT-CT. SPECT-CT on both early and delayed time points, although clinically useful, is not commonly performed to avoid extra radiation exposure from computed tomography (CT). This study explores the feasibility of co-registering early and delayed SPECT-CT from a single CT and evaluates the most effective combination of images for co-registration...
November 2, 2017: Nuclear Medicine Communications
Delphine Vallot, Olivier Caselles, Leonor Chaltiel, Anthony Fernandez, Erwan Gabiache, Lawrence Dierickx, Slimane Zerdoud, Mathilde Bauriaud, Frédéric Courbon
PURPOSE: The aim of this study was to evaluate the impact of using the Bayesian penalized likelihood (BPL) algorithm on a bismuth germanium oxide positron emission tomography (PET)/computed tomography (CT) system for F-FDG PET/CT exams in case of low injected activity and scan duration. MATERIALS AND METHODS: F-FDG respiratory gated PET/CT performed on 102 cancer patients, injected with ∼2 MBq/kg of F-FDG, were reconstructed using two algorithms: ordered subset expectation maximization (OSEM) and BPL...
October 18, 2017: Nuclear Medicine Communications
Danrong Yang, Jianjun Xue, Wenxia Ma, Furong Liu, Yameng Fan, Jie Rong, Aimin Yang, Yan Yu
INTRODUCTION: I therapy is a choice for Graves' hyperthyroidism. Several factors that affect the success of I treatment in Graves' disease (GD) patients have been put forward. The aim of this retrospective study was to evaluate the factors influencing the success of I therapy and the occurrence of hypothyroidism after I therapy. PATIENTS AND METHODS: We reviewed 325 GD patients, who were well documented out of 779 cases, treated with I in the First Affiliated Hospital of Xi'an Jiaotong University between 2010 and 2016...
October 16, 2017: Nuclear Medicine Communications
Lucas Goense, Sophie E Heethuis, Peter S N van Rossum, Francine E M Voncken, Jan J W Lagendijk, Marnix G E H Lam, Chris H Terhaard, Richard van Hillegersberg, Jelle P Ruurda, Stella Mook, Astrid L H M W van Lier, Steven H Lin, Gert J Meijer
OBJECTIVE: Both the apparent diffusion coefficient (ADC) acquired by diffusion-weighted magnetic resonance imaging (DW-MRI) and the standardized uptake value (SUV), acquired by F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT), are well-established functional parameters in cancer imaging. Currently, it is unclear whether these two markers provide complementary prognostic and predictive information in esophageal cancer. The aim of this study was to evaluate the correlation between ADC and SUV in patients with esophageal cancer...
October 11, 2017: Nuclear Medicine Communications
Duc L Nguyen, Claire de Labriolle-Vaylet, Emmanuel Durand, Philippe X Fernandez, François Bonnin, Daniel Deliu, Florent L Besson, Philippe Chaumet-Riffaud
OBJECTIVE: Dynamic renal scintigraphy remains the gold standard for assessing differential renal function (DRF). Recently, technetium-99m-ethylenedicysteine (Tc-EC) was shown to be valuable and had similar quality images as technetium-99m-mercaptoacetyltriglycine (Tc-MAG3). However, its reproducibility has never been confirmed. The aim of this study was to perform the first evaluation of Tc-EC reproducibility for assessing DRF in children who were referred for hydronephrosis or urinary tract dilatation...
October 3, 2017: Nuclear Medicine Communications
Pascal Bailly, Roger Bouzerar, Trevor Shields, Marc-Etienne Meyer, Joël Daouk
BACKGROUND: Fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) is a reliable imaging modality for the diagnosis of malignant lung nodules and to assess the latter's prognosis. However, physiological respiratory motion deteriorates PET images and thus decreases the technique's diagnostic and prognostic values. This issue can be overcome by applying respiratory gating to the F-FDG PET/CT acquisitions. PURPOSE: The aim of this study was to evaluate the ability of respiratory-gated F-FDG PET/CT to diagnose malignant lung nodules and to predict recurrence and patient survival...
October 3, 2017: Nuclear Medicine Communications
Hye Lim Park, Ie Ryung Yoo, Joo Hyun O, Hyoungwoo Kim, Sung Hun Kim, Bong Joo Kang
OBJECTIVE: The aim of this study was to evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in initial axillary lymph node (ALN) staging and tumor recurrence in breast cancer subtypes with low F-FDG avidity in comparison with breast ultrasonography (US) and/or MRI. PATIENTS AND METHODS: A total of 491 PET/CT exams from 192 patients with biopsy-proven breast cancer subtypes with low F-FDG avidity were enrolled retrospectively. Nodal status on staging and locoregional recurrence or metastasis on surveillance was confirmed either by pathology or by further clinical follow-up...
October 3, 2017: Nuclear Medicine Communications
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