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Nuclear Medicine Communications

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https://www.readbyqxmd.com/read/29901488/decrease-in-total-lesion-glycolysis-and-survival-after-yttrium-90-radioembolization-in-poorly-differentiated-hepatocellular-carcinoma-with-portal-vein-tumour-thrombosis
#1
Luca Filippi, Giovan G Di Costanzo, Antonio D'Agostini, Raffaella Tortora, Giuseppe Pelle, Roberto Cianni, Orazio Schillaci, Oreste Bagni
PURPOSE: This study aims to evaluate the prognostic role of the decrease in total lesion glycolysis (TLG) assessed by fluorine-18-fluorodeoxyglucose (F-FDG) PET-computed tomography (CT) 1 month after yttrium-90-radioembolization (Y-RE) in patients affected by hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). PATIENTS AND METHODS: Twenty-one patients with histologically proven poorly differentiated HCC and evidence of PVTT at the enhanced multislice CT underwent Y-RE...
June 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29889690/comparison-between-visual-and-numerical-metrics-for-the-evaluation-of-patients-with-takayasu-arteritis-with-18f-fdg-pet
#2
Berivan Emsen, Khadija Benali, Besma Mahida, Delphine Larivière, Dominique Le Guludec, Thomas Papo, Karim Sacre, Fabien Hyafil
INTRODUCTION: The choice of metrics for defining active Takayasu arteritis (TAK) using fluorine-18-fluorodeoxyglucose (F-FDG)-PET remains controversial. OBJECTIVE: The aim of this study was to compare in the same patients the diagnostic performance for the detection of active TAK of different metrics applied for the quantification of vascular F-FDG uptake with PET. PATIENTS AND METHODS: Overall, 62 PET acquisitions were performed 90 min after F-FDG injection in 15 patients with TAK and analyzed retrospectively...
June 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29889160/extension-of-the-international-atomic-energy-agency-phantom-study-in-image-quantification-results-of-multicentre-evaluation-in-croatia
#3
Darko Grošev, Marin Gregov, Miroslava Radić Wolfl, Branislav Krstonošić, Dea Dundara Debeljuh
To make quantitative methods of nuclear medicine more available, four centres in Croatia participated in the national intercomparison study, following the materials and methods used in the previous international study organized by the International Atomic Energy Agency (IAEA). The study task was to calculate the activities of four Ba sources (T1/2=10.54 years; Eγ=356 keV) using planar and single-photon emission computed tomography (SPECT) or SPECT/CT acquisitions of the sources inside a water-filled cylindrical phantom...
June 7, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29879091/hepatic-selective-internal-radiation-therapy-how-well-does-pretreatment-99mtc-macroaggregated-albumin-activity-distribution-and-quantification-agree-with-post-therapy-bremsstrahlung-imaging
#4
Nathan J Dickinson, Charnie Kalirai, Richard A O'Connor, Karen Mullin
AIM: The aim of this study was to examine the agreement of pretreatment Tc-macroaggregated albumin imaging performed for selective internal radiation therapy (SIRT) workup with Y percentage lung shunt (PLS) and regional hepatic distribution in subsequent post-therapy bremsstrahlung imaging. PATIENTS AND METHODS: Planar images were used to calculate PLS. The significant Y bremsstrahlung scatter required background correction. Results using both Y lung background regions of interest (ROI) reported in previous studies and extended ROIs (reflecting lung background variation) were compared with Tc-MAA PLS...
June 6, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29877994/assessment-of-normal-reference-values-for-thyroid-uptake-of-technetium-99m-pertechnetate-in-a-single-centre-uk-population
#5
Mavin Macauley, Mohamed Shawgi, Tamir Ali, Andrew Curry, Kim Howe, Elizabeth Howell, Elizabeth Jefferson, Andrew James, Petros Perros, George S Petrides
OBJECTIVE: This study aims to explore the normal reference values for thyroid uptake of technetium-99m (Tc) pertechnetate in a UK population. PATIENTS AND METHODS: A retrospective review of 60 euthyroid patients who underwent thyroid imaging with Tc pertechnetate between January 2012 to April 2014 as part of dual-tracer subtraction parathyroid scintigraphy. Tc pertechnetate thyroid uptake values were determined for each patient. Medical records and biochemical thyroid function tests were reviewed to ensure that all patients were not on medication that could affect thyroid function and they were both clinically and biochemically euthyroid 6 months before and following the scan...
June 6, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29877993/99mtc-phy-portal-perfusion-index-imaging-helps-predict-the-severity-of-hepatitis-b-virus-cirrhosis-a-preliminary-study
#6
Ning-Hu Liu, Meng-Jie Dong, Hao Liu, Xi-Li Lu, Dan Tian, Jun Zhang, Jun Yang, Jun-Hui Sun, Li-Hua Wu, Jian-Li Bi, Bo Zhang
OBJECTIVE: The aim was to perform exploratory research on the application of technetium phytate (Tc-Phy) portal perfusion index (PPI) imaging in predicting the complications of hepatitis B cirrhosis and their severity. PATIENTS AND METHODS: A total of 65 hepatitis B cirrhosis patients were stratified, respectively, into three groups from classes A to C according to Child-Pugh scores and five groups from stages 1 to 5 according to the five-stage prognostic system...
June 6, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29877992/123i-iomazenil-whole-body-imaging-to-detect-hepatic-carboxylesterase-drug-metabolizing-enzyme-activity
#7
Asuka Mizutani, Masato Kobayashi, Ken-Ichi Fujita, Kotaro Takahashi, Tsuzumi Hokama, Hiroaki Takasu, Kodai Nishi, Ryuichi Nishii, Naoto Shikano, Kazuki Fukuchi, Keiichi Kawai
OBJECTIVES: Drugs are mainly metabolized by hepatic enzymes, the activity of which can differ between individuals. Although it is ideal to measure the hepatic clearance of liver-targeted drugs in individualized medicine, blood enzyme tests typically measure metabolic drug clearance in the entire body, and not just in the liver. We investigated whether I-iomazenil imaging can directly assess and quantify the activity of hepatic drug-metabolizing enzymes. MATERIALS AND METHODS: Hepatic enzymes that metabolize I-iomazenil were identified by thin-layer chromatography in mouse liver homogenates with bis(4-nitrophenyl) phosphate (BNPP) inhibitor for carboxylesterase enzymes and nicotinamide adenine dinucleotide phosphate (NADPH) generator for cytochrome P450 enzymes...
June 5, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29851772/gallium-68-dota-noc-pet-ct-as-an-alternate-predictor-of-disease-activity-in-sarcoidosis
#8
Sanchit Sharma, Achintya D Singh, Surendra K Sharma, Madhavi Tripathi, Chandan J Das, Rajeev Kumar
INTRODUCTION: We evaluated the role of gallium-68-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-Nal3-octreotide (Ga-DOTA-NOC) PET/CT in assessing sarcoidosis disease activity. PATIENTS AND METHODS: Patients diagnosed with sarcoidosis underwent Ga-DOTA-NOC-PET/CT. The maximum standardized uptake value (SUVmax) at the pathological site and in the descending thoracic aorta (reference standard, SUVmed) were assessed. A SUVmax/SUVmed ratio (disease activity score) of more than one was considered a marker of active disease and was compared with the clinical symptoms and serum angiotensin-converting enzyme and computed tomography (CT) scan...
May 30, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29846298/a-case-series-of-outcomes-in-isolated-subsegmental-pulmonary-embolism-on-ventilation-perfusion-imaging
#9
Amy Mallorie, Kenneth Chan, Stefanos Ioannidis, Matthew Stubbs, Shaunak Navalkissoor, Thomas Wagner
OBJECTIVES: The risk of recurrent venous thromboembolic disease and the management of patients with isolated subsegmental pulmonary embolism (SSPE) remain unclear. We sought to assess the long-term clinical outcome of patients with isolated SSPE demonstrated by isolated subsegmental mismatch found on ventilation/perfusion (V/Q) scans. PATIENTS AND METHODS: We performed a retrospective observational study of 1300 consecutive patients with suspected pulmonary embolism who underwent index V/Q single-photon emission computed tomography between 2012 and 2013...
May 25, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29794947/myocardial-stunning-induced-left-ventricular-dyssynchrony-on-gated-single-photon-emission-computed-tomography-myocardial-perfusion-imaging
#10
Zhixin Jiang, Haipeng Tang, Jianzhou Shi, Yanli Zhou, Cheng Wang, Dianfu Li, Qijun Shan, Weihua Zhou
OBJECTIVES: Myocardial stunning provides additional nonperfusion markers of coronary artery disease (CAD), especially for severe multivessel CAD. The purpose of this study is to assess the influence of myocardial stunning to the changes of left ventricular mechanical dyssynchrony (LVMD) parameters between stress and rest gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). PATIENTS AND METHODS: A total of 113 consecutive patients (88 males and 25 females) who had undergone both stress and rest Tc-sestamibi gated SPECT MPI were retrospectively enrolled...
May 23, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29790867/fluorine-18-fluorocholine-pet-ct-parameters-predictive-for-hematological-toxicity-to-radium-223-therapy-in-castrate-resistant-prostate-cancer-patients-with-bone-metastases-a-pilot-study
#11
Lavinia Vija Racaru, Mathieu Sinigaglia, Salim Kanoun, Fayçal Ben Bouallègue, Ilan Tal, Sévérine Brillouet, Mathilde Bauriaud-Mallet, Slimane Zerdoud, Lawrence Dierickx, Delphine Vallot, Olivier Caselles, Erwan Gabiache, Pierre Pascal, Frederic Courbon
PURPOSE: This study aims to predict hematological toxicity induced by Ra therapy. We investigated the value of metabolically active bone tumor volume (MBTV) and total bone lesion activity (TLA) calculated on pretreatment fluorine-18-fluorocholine (F-FCH) PET/CT in castrate-resistant prostate cancer (CRPC) patients with bone metastases treated with Ra radionuclide therapy. PATIENTS AND METHODS: F-FCH PET/CT imaging was performed in 15 patients with CRPC before treatment with Ra...
May 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29787517/applying-standardized-uptake-values-in-gallium-67-citrate-single-photon-emission-computed-tomography-computed-tomography-studies-and-their-correlation-with-blood-test-results-in-representative-organs
#12
Akira Toriihara, Hiromitsu Daisaki, Akihiro Yamaguchi, Katsuya Yoshida, Jun Isogai, Ukihide Tateishi
OBJECTIVES: Recently, semiquantitative analysis using standardized uptake value (SUV) has been introduced in bone single-photon emission computed tomography/computed tomography (SPECT/CT). Our purposes were to apply SUV-based semiquantitative analytic method for gallium-67 (Ga)-citrate SPECT/CT and to evaluate correlation between SUV of physiological uptake and blood test results in representative organs. METHODS: The accuracy of semiquantitative method was validated using an National Electrical Manufacturers Association body phantom study (radioactivity ratio of sphere : background=4 : 1)...
May 21, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29782393/clinical-and-prognostic-value-of-18f-fdg-pet-ct-in-restaging-of-pancreatic-cancer
#13
Domenico Albano, Demetrio Familiari, Roberta Gentile, Salvatore Scalisi, Federico Midiri, Marco Messina, Massimiliano Spada, Maria C Fornito, Massimo Galia, Massimo Midiri, Pierpaolo Alongi
AIM: The aim of this retrospective multicentre study was to evaluate the clinical and prognostic effect of fluorine-18-fluorodeoxyglucose (F-FDG)-PET/computed tomography (CT) in the restaging process of pancreatic cancer (PC). MATERIALS AND METHODS: Data from patients treated for primary PC, who underwent F-FDG-PET/CT for suspicious of disease progression, were collected. Accuracy was assessed employing conventional diagnostic procedures, multidisciplinary team case notes, further F-FDG-PET/CT scans and/or follow-up...
May 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29771717/prognostic-predictive-value-of-preoperative-intratumoral-2-deoxy-2-18f-fluoro-d-glucose-uptake-heterogeneity-in-patients-with-high-grade-serous-ovarian-cancer
#14
Shuai Liu, Zheng Feng, Zhaoxia Jiang, Hao Wen, Junyan Xu, Herong Pan, Yu Deng, Lei Zhang, Xingzhu Ju, Xiaojun Chen, Xiaohua Wu
OBJECTIVE: This study aimed to explore the clinical and prognostic significance of pretreatment positron-emission tomography/computed tomography (PET/CT) parameters, especially 2-deoxy-2-(F)fluoro-D-glucose-based heterogeneity, in high-grade serous ovarian cancer (HGSC). MATERIALS AND METHODS: We retrospectively investigated 56 patients with HGSC who underwent PET/CT before primary surgery at our hospital between January 2010 and June 2015. None of these patients received neoadjuvant chemotherapy...
May 16, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29771718/evaluation-of-drug-effects-on-cerebral-blood-flow-and-glucose-uptake-in-un-anesthetized-and-un-stimulated-rats-application-of-free-moving-apparatus-enabling-to-keep-rats-free-during-pet-spect-tracer-injection-and-uptake
#15
Taku Sugita, Yusuke Kondo, Seigo Ishino, Ikuo Mori, Takashi Horiguchi, Mikako Ogawa, Yasuhiro Magata
OBJECTIVES: The purpose of this study is the development of novel fluorine-18-fluorodeoxyglucose (F-FDG)-PET and Tc-hexamethylpropylene amine oxime (HMPAO) SPECT methods with free-moving apparatus on conscious rats to investigate brain activity without the effects of anesthesia and tactual stimulation. We also assessed the sensitivity of the experimental system by an intervention study using fluoxetine as a reference drug. MATERIALS AND METHODS: A catheter was inserted into the femoral vein and connected to a free-moving cannula system...
May 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29762262/18f-fluorodeoxyglucose-positron-emission-tomography-combined-with-computed-tomography-as-a-diagnostic-tool-in-native-valve-endocarditis
#16
Ilse J E Kouijzer, Marvin A H Berrevoets, Erik H J G Aarntzen, Janneke de Vries, Arie P J van Dijk, Wim J G Oyen, Lioe-Fee de Geus-Oei, Chantal P Bleeker-Rovers
OBJECTIVE: The aim of the study was to investigate the value of F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). PATIENTS AND METHODS: All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and F-FDG-PET/CT were performed within 14 days. F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians...
May 14, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29762261/a-retrospective-study-of-the-clinical-features-in-papillary-thyroid-microcarcinoma-depending-on-age
#17
Xuan Wang, Jian Tan, Wei Zheng, Ning Li
The aim of this study was to evaluate the clinical features and correlation of neck lymph node involvement of papillary thyroid microcarcinoma (PTMC) according to patients' age. We divided the patients into three groups according to age: young group (<45 years, n=83), middle group (45-54 years, n=80), and old group (≥55 years, n=53). The clinical features among the different groups were analyzed retrospectively. All of the 216 patients had received radioiodine ablation at least one time. Among these, 84 patients had central lymph node metastasis (CLNM), 11 patients had lateral lymph node metastasis (LLNM), and 26 patients had both CLNM and LLNM...
May 14, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29738349/a-pilot-study-of-pancreatic-islet-amyloid-pet-imaging-with-18f-fddnp
#18
Zhi Lu, Jinghui Xie, Ran Yan, Zilin Yu, Zhigang Sun, Fei Yu, Xiaoyan Gong, Hongbo Feng, Jing Lu, Yanjun Zhang
OBJECTIVES: Pancreatic islet amyloid deposition occurs before β-cell damage in type 2 diabetes mellitus patients. The islet and Alzheimer's disease β-amyloid shares similar secondary structures. The Alzheimer's disease β-amyloid targeting tracer [F]FDDNP could be used to image pancreatic islet amyloid with PET. PATIENTS AND METHODS: Consecutive pancreatic tissue sections from a 69-year-old male type 2 diabetes mellitus patient were stained by hematoxylin and eosin, anti-amylin antibody, Congo Red, periodic acid-Schiff, and [F]FDDNP reference compound, respectively...
May 5, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29608508/tumor-heterogeneity-hypoxia-and-immune-markers-in-surgically-resected-non-small-cell-lung-cancer
#19
Angelo Castello, Fabio Grizzi, Luca Toschi, Sabrina Rossi, Daoud Rahal, Federica Marchesi, Carlo Russo, Giovanna Finocchiaro, Egesta Lopci
OBJECTIVES: This study aimed to determine the prognostic role of textural features and their association with metabolic parameters, hypoxia, and cancer-related immune markers in non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: The trial was registered at http://www.clinicaltrials.gov (NCT02519062). From January 2010 to May 2014, 44 patients (male : female=33 : 11; median age: 69.5 years), referred to our Institution for NSCLC resection, were enrolled...
March 30, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29561475/study-of-the-peak-splitting-in-an-alternative-method-for-the-radiochemical-purity-measurement-of-99mtechnetium-sestamibi
#20
Manuel Montoza-Aguado, Carlos Salgado-García, Luis Falcón-Márquez, Ana Luna-Alcaide, Amelia Jiménez-Heffernan, Carmen Puentes-Zarzuela
One of the alternative methods for the measurement of radiochemical purity (RCP) of Technetium-sestamibi uses Whatman 3MM paper as the stationary phase and ethyl acetate as the mobile phase. However, alternative method shows peak splitting and shouldering of the radiopharmaceutical. This could be because of higher levels of analyte. We aimed to assess the effect of sample dilution (1 : 1) on this method and to compare these RCP values with the reference method. The diluted samples showed a unique peak in the radiopharmaceutical zone, but the RCP values were significantly different (P<0...
March 20, 2018: Nuclear Medicine Communications
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