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Cephalalgia: An International Journal of Headache

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https://www.readbyqxmd.com/read/29504483/a-multicenter-prospective-single-arm-open-label-observational-study-of-stms-for-migraine-prevention-espouse-study
#1
Amaal J Starling, Stewart J Tepper, Michael J Marmura, Ejaz A Shamim, Matthew S Robbins, Nada Hindiyeh, Andrew C Charles, Peter J Goadsby, Richard B Lipton, Stephen D Silberstein, Amy A Gelfand, Richard P Chiacchierini, David W Dodick
Objective To evaluate the efficacy and tolerability of single pulse transcranial magnetic stimulation (sTMS) for the preventive treatment of migraine. Background sTMS was originally developed for the acute treatment of migraine with aura. Open label experience has suggested a preventive benefit. The objective of this trial was to evaluate the efficacy and tolerability of sTMS for migraine prevention. Methods The eNeura SpringTMS Post-Market Observational U.S. Study of Migraine (ESPOUSE) Study was a multicenter, prospective, open label, observational study...
May 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29471679/arise-a-phase-3-randomized-trial-of-erenumab-for-episodic-migraine
#2
David W Dodick, Messoud Ashina, Jan Lewis Brandes, David Kudrow, Michel Lanteri-Minet, Vera Osipova, Kerry Palmer, Hernan Picard, Daniel D Mikol, Robert A Lenz
Background Calcitonin gene-related peptide plays an important role in migraine pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, is being evaluated for migraine prevention. Methods In this randomized, double-blind, placebo-controlled, phase 3 study, 577 adults with episodic migraine were randomized to placebo or 70 mg erenumab; 570 patients were included in efficacy analyses. Primary endpoint was change in monthly migraine days. Secondary endpoints were ≥50% reduction in monthly migraine days, change in acute migraine-specific medication treatment days, and ≥5-point reduction in Physical Impairment and Impact on Everyday Activities domain scores measured by the Migraine Physical Function Impact Diary...
May 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29310444/safety-of-galcanezumab-in-patients-with-episodic-migraine-a-randomized-placebo-controlled-dose-ranging-phase-2b-study
#3
Tina Marie Myers Oakes, Vladimir Skljarevski, Qi Zhang, William Kielbasa, Michael E Hodsdon, Holland C Detke, Angelo Camporeale, Joel R Saper
Background Safety findings from a Phase 2b study of galcanezumab, a humanized monoclonal antibody against calcitonin gene-related peptide, for prevention of migraine (NCT02163993) are reported here. Methods Patients aged 18-65 years with episodic migraine were evaluated in this multicenter, double-blind, randomized study. After randomization, 410 patients were administered 5, 50, 120 or 300 mg of galcanezumab or placebo subcutaneously once every 4 weeks for 12 weeks, followed by a post-treatment off-drug period lasting 12 weeks...
May 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29589514/board-walk-april-2018
#4
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29504482/guidelines-of-the-international-headache-society-for-controlled-trials-of-preventive-treatment-of-chronic-migraine-in-adults
#5
Cristina Tassorelli, Hans-Christoph Diener, David W Dodick, Stephen D Silberstein, Richard B Lipton, Messoud Ashina, Werner J Becker, Michel D Ferrari, Peter J Goadsby, Patricia Pozo-Rosich, Shuu-Jiun Wang
Background Quality clinical trials form an essential part of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Migraine. In 2008, the Committee published the first specific guidelines on chronic migraine. Subsequent advances in drug, device, and biologicals development, as well as novel trial designs, have created a need for a revision of the chronic migraine guidelines...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28691517/migraine-triggers-and-habituation-of-visual-evoked-potentials
#6
Marco Lisicki, Emiliano Ruiz-Romagnoli, Raúl Piedrabuena, Roberto Giobellina, Jean Schoenen, Delphine Magis
Background Identifying specific subsets of patients within the clinical spectrum of migraine could help in personalizing migraine treatment. Profiling patients by combining clinical characteristics and neurophysiological biomarkers is largely unexplored. We studied the association between migraine attack triggers and habituation of visual evoked potentials. Methods We personally interviewed 25 patients about their migraine triggers following a structured list, and measured the N1-P1 habituation slope over six blocks of 100 averaged pattern-reversal VEP afterwards...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28677994/reproducibility-of-migraine-like-attacks-induced-by-phosphodiesterase-3-inhibitor-cilostazol
#7
Sabrina Khan, Marie Deen, Anders Hougaard, Faisal Mohammad Amin, Messoud Ashina
Introduction The phosphodiesterase-3-inhibitor cilostazol induces migraine-like attacks in patients with migraine without aura, and may be used as a pharmacological trigger in human experimental models of migraine. However, the reproducibility of cilostazol-induced migraine-like attacks has never been investigated. Methods We performed a post-hoc analysis of clinical data from two brain-imaging studies including subjects who had received cilostazol 200 mg orally. Only subjects who developed migraine-like attacks on study day 1 were included on study day 2...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28641450/musculoskeletal-dysfunction-in-migraine-patients
#8
Kerstin Luedtke, Wiebke Starke, Arne May
Objective The aim of this project was to evaluate the prevalence and pattern of musculoskeletal dysfunctions in migraine patients using a rigorous methodological approach and validating an international consensus cluster of headache assessment tests. Methods A physiotherapist, blinded towards the diagnosis, examined 138 migraine patients (frequent episodic and chronic), recruited at a specialised headache clinic, and 73 age and gender matched healthy controls following a standardised protocol. Eleven tests, previously identified in an international consensus procedure, were used to evaluate cervical and thoracic musculoskeletal dysfunctions...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28610434/isoflavones-and-gastrointestinal-infection-two-potential-triggers-for-reversible-cerebral-vasoconstriction-syndrome
#9
Björn Machner, Tobias Boppel, Thomas Münte
Background Reversible cerebral vasoconstriction syndrome (RCVS) is an important differential diagnosis of singular or recurrent thunderclap headache. Prognosis is generally good, however complications of the transient segmental vasospasms of cerebral arteries such as stroke, subarachnoidal hemorrhage and brain edema may worsen the clinical outcome. Although the exact pathomechanism is still unclear, various vasoactive substances and conditions (e.g. post partum) have been identified as triggering RCVS. Cases We report on the clinical course and management of two cases of typical RCVS that were associated with two different precipitants previously not described: A gastrointestinal infection and isoflavones, which are phytoestrogens used for menopausal vasomotor symptoms...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28554244/effectiveness-of-the-progestin-only-pill-for-migraine-treatment-in-women-a-systematic-review-and-meta-analysis
#10
Samantha Warhurst, Christopher J Rofe, Bruce J Brew, Deborah Bateson, Kevin McGeechan, Gabriele S Merki-Feld, Raymond Garrick, Susan E Tomlinson
Background Migraine is highly prevalent in women (18%). Peak morbidity affects their most productive years, coinciding with peak fertility. Hormonal contraception is often tailored for migraine prevention. Estrogen-containing contraceptives may be contraindicated in women experiencing migraine with aura due to the risk of vascular events. While improvements in migraine with a progestin-only pill (POP), which inhibits ovulation are documented, the strength and quality of evidence has not been formally evaluated...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28474987/idiopathic-hypertrophic-pachymeningitis-mimicking-hemicrania-continua-an-unusual-clinical-case
#11
Antonio Russo, Marcello Silvestro, Mario Cirillo, Alessandro Tessitore, Gioacchino Tedeschi
Background Hemicrania continua (HC) is a primary headache syndrome characterized by a unilateral, moderate, continuous headache with exacerbations marked by migrainous and cranial autonomic symptoms. However, clinical phenotypes similar to primary HC may be subtended by several disorders. Case report We report the case of a 62-year-old man experiencing, over the previous year, a headache completely consistent with HC and its absolute responsiveness to indomethacin therapy. Later, the patient developed diplopia caused by sixth cranial nerve palsy ipsilateral to headache...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28474985/prevalence-and-extent-of-right-to-left-shunt-on-contrast-enhanced-transcranial-doppler-in-chinese-patients-with-migraine-in-a-multicentre-case-control-study
#12
Si-Bo Wang, Kang-Ding Liu, Yi Yang, Ya-Jie Li, Ming-Yi Hu, Pan Lin, Rong Guo, Qian Tian, Yong You, Ying-Hua Cui, Guan-Ling Zhang, Zhao Dong, Yong-Sheng Gao, Ying-Qi Xing
Background The association between RLS and migraine is still debated. The aim of this study is to investigate the prevalence and grade of RLS in Chinese patients with migraine and to evaluate the relationship between RLS and migraine. Methods A multi-center case-control study of contrast-enhanced transcranial Doppler was conducted in 931 consecutive patients with migraine (240 of 931 had migraine with aura and 691 of 931 were in the migraine without aura group) and 282 were healthy adults. Clinical trial no...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28457145/region-specific-disruption-of-the-blood-brain-barrier-following-repeated-inflammatory-dural-stimulation-in-a-rat-model-of-chronic-trigeminal-allodynia
#13
Nathan T Fried, Christina R Maxwell, Melanie B Elliott, Michael L Oshinsky
Background The blood-brain barrier (BBB) has been hypothesized to play a role in migraine since the late 1970s. Despite this, limited investigation of the BBB in migraine has been conducted. We used the inflammatory soup rat model of trigeminal allodynia, which closely mimics chronic migraine, to determine the impact of repeated dural inflammatory stimulation on BBB permeability. Methods The sodium fluorescein BBB permeability assay was used in multiple brain regions (trigeminal nucleus caudalis (TNC), periaqueductal grey, frontal cortex, sub-cortex, and cortex directly below the area of dural activation) during the episodic and chronic stages of repeated inflammatory dural stimulation...
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28427279/does-headache-research-need-more-or-less-journals-cephalalgia-and-open-access
#14
Arne May
No abstract text is available yet for this article.
April 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952348/paediatric-headache-trajectories-a-reappraisal-after-nine-years
#15
Corinna Isensee, York Hagmayer, Carolin Fernandez Castelao, Birgit Kröner-Herwig
Background The long-term consequences of paediatric headache can involve functional disabilities and mental health problems in adulthood. Objective To analyse the predictive power of paediatric headache trajectory classes for headache and related outcomes in adulthood. Methods In a previous study, a population-based sample (N = 3227, 9-14 years of age at first assessment) was followed across four annual assessment points, and sex-specific headache trajectory classes were identified (girls: "no pain", "moderate pain", "increasing pain", "high pain"; boys: "no pain", "moderate pain")...
March 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952339/altered-brainstem-anatomy-in-migraine
#16
Kasia K Marciszewski, Noemi Meylakh, Flavia Di Pietro, Vaughan G Macefield, Paul M Macey, Luke A Henderson
Background The exact mechanisms responsible for migraine remain unknown, although it has been proposed that changes in brainstem anatomy and function, even between attacks, may contribute to the initiation and maintenance of headache during migraine attacks. The aim of this investigation is to use brainstem-specific analyses of anatomical and diffusion weighted images to determine if the trigeminal system displays altered structure in individuals with migraine. Methods Voxel-based morphometry of T1-weighted anatomical images (57 controls, 24 migraineurs) and diffusion tensor images (22 controls, 24 migraineurs) were used to assess brainstem anatomy in individuals with migraine compared with controls...
March 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952338/cilostazol-as-a-chemically-induced-preclinical-model-of-migraine
#17
Philip R Holland, Lauren Strother
No abstract text is available yet for this article.
March 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952337/gamma-knife-radiosurgery-for-glossopharyngeal-neuralgia-a-study-of-21-patients-with-long-term-follow-up
#18
Pierre-Yves Borius, Constantin Tuleasca, Xavier Muraciole, Laura Negretti, Luis Schiappacasse, Antoine Dorenlot, Maud Marguet, Michele Zeverino, Anne Donnet, Marc Levivier, Jean Regis
Objective Glossopharyngeal neuralgia (GPN) is a very rare condition, affecting the patient's quality of life. We report our experience in drug-resistant, idiopathic GPN, treated with Gamma Knife radiosurgery (GKRS), in terms of safety and efficiency, on a very long-term basis. Methods The study was opened, self-controlled, non-comparative and bicentric (Marseille and Lausanne University Hospitals). Patients treated with GKRS between 2003 and 2015 (models C, 4C and Perfexion) were included. A single 4-mm isocentre was positioned in the cisternal portion of the glossopharyngeal nerve, with a targeting based both on magnetic resonance imaging (MRI) and computed tomography (CT)...
March 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952330/genome-wide-association-study-identifies-novel-susceptibility-loci-for-migraine-in-han-chinese-resided-in-taiwan
#19
Shih-Pin Chen, Jong-Ling Fuh, Ming-Yi Chung, Ying-Chao Lin, Yi-Chu Liao, Yen-Feng Wang, Chia-Lin Hsu, Ueng-Cheng Yang, Ming-Wei Lin, Jen-Jie Chiou, Po-Jen Wang, Ping-Kun Chen, Pi-Chuan Fan, Jer-Yuan Wu, Yuan-Tsong Chen, Lung-Sen Kao, Cathy Shen-Jang Fann, Shuu-Jiun Wang
Background Susceptibility genes for migraine, despite it being a highly prevalent and disabling neurological disorder, have not been analyzed in Asians by genome-wide association study (GWAS). Methods We conducted a two-stage case-control GWAS to identify susceptibility genes for migraine without aura in Han Chinese residing in Taiwan. In the discovery stage, we genotyped 1005 clinic-based Taiwanese migraine patients and 1053 population-based sex-matched controls using Axiom Genome-Wide CHB Array. In the replication stage, we genotyped 27 single-nucleotide polymorphisms with p < 10-4 in 1120 clinic-based migraine patients and 604 sex-matched normal controls by using Sequenom...
March 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28952329/headache-in-cerebral-venous-sinus-thrombosis-revisited-exploring-the-role-of-vascular-congestion-and-cortical-vein-thrombosis
#20
Ravinder-Jeet Singh, Jitender Saini, Shriram Varadharajan, Girish Baburao Kulkarni, Mustare Veerendrakumar
Background and purpose Headache constitutes the most common symptom of cerebral venous sinus thrombosis (CVST), but its pathophysiology is unclear. We sought to investigate the potential mechanism for headache genesis in patients with CVST based on its imaging correlates. Methods A subgroup of CVST patients having headache as the predominant symptom without significant parenchymal lesion were retrospectively analysed for imaging features of vascular congestion (VC), in addition to cortical venous (CVT) and dural sinus thrombosis (DST) on magnetic resonance imaging...
March 2018: Cephalalgia: An International Journal of Headache
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