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Cephalalgia: An International Journal of Headache

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https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#1
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27895210/-dr-google-will-see-you-now-time-trends-in-online-searches-on-headache
#2
EDITORIAL
Marcelo D Mendonça, André Caetano, Miguel Viana-Baptista
No abstract text is available yet for this article.
November 28, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27884929/pro-nociceptive-migraine-mediator-cgrp-provides-neuroprotection-of-sensory-cortical-and-cerebellar-neurons-via-multi-kinase-signaling
#3
Polina A Abushik, Geneviève Bart, Paula Korhonen, Hanna Leinonen, Raisa Giniatullina, Dmitry A Sibarov, Anna-Liisa Levonen, Tarja Malm, Sergei M Antonov, Rashid Giniatullin
BACKGROUND: Blocking the pro-nociceptive action of CGRP is one of the most promising approaches for migraine prophylaxis. The aim of this study was to explore a role for CGRP as a neuroprotective agent for central and peripheral neurons. METHODS: The viability of isolated rat trigeminal, cortical and cerebellar neurons was tested by fluorescence vital assay. Engagement of Nrf2 target genes was analyzed by qPCR. The neuroprotective efficacy of CGRP in vivo was tested in mice using a permanent cerebral ischemia model...
November 24, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27881687/bilateral-cisternal-abducens-nerve-involvement-with-ophthalmoplegic-migraine
#4
EDITORIAL
Richa Tripathi, Alexandros Tselis, Evanthia Bernitsas
No abstract text is available yet for this article.
November 23, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27872339/visual-and-auditory-cortical-evoked-potentials-in-interictal-episodic-migraine-an-audit-on-624-patients-from-three-centres-response-to-the-letter-by-omland-et-al
#5
EDITORIAL
Anna Ambrosini, Aliaksei Kisialiou, Jean Schoenen
No abstract text is available yet for this article.
November 21, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27872338/re-visual-and-auditory-cortical-evoked-potentials-in-interictal-episodic-migraine-an-audit-on-624-patients-from-three-centres
#6
EDITORIAL
Petter Moe Omland, Martin Uglem, Lars Jacob Stovner, Trond Sand
No abstract text is available yet for this article.
November 21, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27852962/anatomy-and-immunochemical-characterization-of-the-non-arterial-peptidergic-diffuse-dural-innervation-of-the-rat-and-rhesus-monkey-implications-for-functional-regulation-and-treatment-in-migraine
#7
Frank L Rice, Jennifer Y Xie, Phillip J Albrecht, Emily Acker, Justin Bourgeois, Edita Navratilova, David W Dodick, Frank Porreca
OBJECTIVE: The interplay between neuronal innervation and other cell types underlies the physiological functions of the dura mater and contributes to pathophysiological conditions such as migraine. We characterized the extensive, but understudied, non-arterial diffuse dural innervation (DDI) of the rat and Rhesus monkey. METHODS: We used a comprehensive integrated multi-molecular immunofluorescence labeling strategy to extensively profile the rat DDI and to a lesser extent that of the Rhesus monkey...
November 16, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919023/does-pain-sensitivity-change-by-migraine-phase-a-blinded-longitudinal-study
#8
Martin Uglem, Petter Moe Omland, Kristian Bernhard Nilsen, Erling Tronvik, Lars Jacob Stovner, Knut Hagen, Mattias Linde, Trond Sand
OBJECTIVE: Studies suggest that pain thresholds may be altered before and during migraine headaches, but it is still debated if a central or peripheral dysfunction is responsible for the onset of pain in migraine. The present blinded longitudinal study explores alterations in thermal pain thresholds and suprathreshold heat pain scores before, during, and after headache. METHODS: We measured pain thresholds to cold and heat, and pain scores to 30 seconds of suprathreshold heat four times in 49 migraineurs and once in 31 controls...
November 15, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919024/trigger-points-are-associated-with-widespread-pressure-pain-sensitivity-in-people-with-tension-type-headache
#9
María Palacios-Ceña, Kelun Wang, Matteo Castaldo, Amparo Guillem-Mesado, Carlos Ordás-Bandera, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate the association between trigger points (TrPs) and widespread pressure pain sensitivity in people with tension-type headache (TTH) and to determine if this association is different between frequent episodic (FETTH) or chronic (CTTH) headache. DESIGN: A cross-sectional study. METHODS: One hundred and fifty-seven individuals (29% male) with TTH participated. Clinical features of headache, i.e., intensity, duration, and frequency, were recorded in a headache diary...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919022/hippocampus-and-amygdala-volume-in-relation-to-migraine-frequency-and-prognosis
#10
Hung-Yu Liu, Kun-Hsien Chou, Pei-Lin Lee, Jong-Ling Fuh, David M Niddam, Kuan-Lin Lai, Fu-Jung Hsiao, Yung-Yang Lin, Wei-Ta Chen, Shuu-Jiun Wang, Ching-Po Lin
OBJECTIVES: To investigate the structural changes of hippocampus and amygdala and their relationships with migraine frequency and prognosis. METHODS: Hippocampus and amygdala volumes were measured by 3-T brain magnetic resonance imaging (MRI) in 31 controls and 122 migraine patients who were categorized into eight groups by headache frequency: group 1 (1-2 headache days/month), 2 (3-4), 3 (5-7), 4 (8-10), 5 (11-14), 6 (15-19), 7 (20-24), and 8 (25-30). Headache frequency was reassessed 2 years later and a frequency reduction ≥50% was regarded a good outcome...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919021/a-lost-track-in-ichd-3-beta-a-comprehensive-review-on-osmophobia
#11
Giorgio Zanchin, Matteo Fuccaro, Pierantonio Battistella, Mario Ermani, Federico Mainardi, Ferdinando Maggioni
BACKGROUND: Osmophobia (Os) has been reported to be much more prevalent in migraine (M) than in other primary headaches, and its high specificity in the differential diagnosis between M and tension-type headache (TTH) has been reported. Os was included in the ICHD II Appendix as a diagnostic criterion of M. It disappeared in ICHD-3 beta. To understand this choice, we reviewed the literature after 2004. METHODS: This was a systematic review. We searched in PubMed, MEDLINE and Cochrane library for "osmophobia", "odour/odorphobia AND headache", "odour/odor hypersensitivity AND headache" and "olfactory hypersensitivity AND headache"...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919017/effects-of-kynurenic-acid-analogue-1-kyna-a1-in-nitroglycerin-induced-hyperalgesia-targets-and-anti-migraine-mechanisms
#12
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elisa Redavide, Selena Pampalone, Joseph Toldi, Ferenc Fülöp, Fabio Blandini, Giuseppe Nappi, Giorgio Sandrini, László Vécsei, Cristina Tassorelli
BACKGROUND: Trigeminal sensitization represents a major mechanism underlying migraine attacks and their recurrence. Nitroglycerin (NTG) administration provokes spontaneous migraine-like headaches and in rat, an increased sensitivity to the formalin test. Kynurenic acid (KYNA), an endogenous regulator of glutamate activity and its analogues attenuate NTG-induced neuronal activation in the nucleus trigeminalis caudalis (NTC). The anti-hyperalgesic effect of KYNA analogue 1 (KYNA-A1) was investigated on animal models specific for migraine pain...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27837174/growth-of-headache-research-a-1983-2014-bibliometric-study
#13
REVIEW
Claude Robert, Concepción S Wilson, Richard B Lipton, Charles-Daniel Arreto
AIM: This study charts the growth of the scientific journal literature on headache for 30+ years (1983-2014). METHODS: Using the Web of Science, articles published in four two-year periods (1983-1984, 1993-1994, 2003-2004, 2013-2014) from journals indexed in the Science Citation Index Expanded database were retrieved and analyzed. RESULTS: From 1983-1984 to 2013-2014, the scientific literature on headache increased nearly fourfold (3.8) from 468 to 1776 articles; the number of participating countries more than doubled (26 to 67); and the two most prolific countries in each period were the USA and Italy...
November 11, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27837173/persistence-and-switching-patterns-of-oral-migraine-prophylactic-medications-among-patients-with-chronic-migraine-a-retrospective-claims-analysis
#14
Zsolt Hepp, David W Dodick, Sepideh F Varon, Jenny Chia, Nitya Matthew, Patrick Gillard, Ryan N Hansen, Emily Beth Devine
BACKGROUND: Migraine prevention guidelines recommend oral prophylactic medications for patients with frequent headache. This study examined oral migraine preventive medication (OMPM) treatment patterns by evaluating medication persistence, switching, and re-initiation in patients with chronic migraine (CM). METHODS: A retrospective US claims analysis (Truven Health MarketScan® Databases) evaluated patients ≥18 years old diagnosed with CM who had initiated an OMPM between 1 January, 2008 and 30 September, 2012...
November 10, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27837172/comments-on-longitudinal-changes-in-cerebral-blood-flow-velocities-in-different-clinical-courses-of-migraine-by-lee-et%C3%A2-al
#15
EDITORIAL
Ole Hensel
No abstract text is available yet for this article.
November 10, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919019/induction-of-calcitonin-gene-related-peptide-expression-in-rats-by-cortical-spreading-depression
#16
Yan Wang, Anne E Tye, Junli Zhao, Dongqing Ma, Ann C Raddant, Fan Bu, Benjamin L Spector, Nolan K Winslow, Minyan Wang, Andrew F Russo
OBJECTIVE: The neuropeptide calcitonin gene-related peptide (CGRP) has now been established as a key player in migraine. However, the mechanisms underlying the reported elevation of CGRP in the serum and cerebrospinal fluid of some migraineurs are not known. A candidate mechanism is cortical spreading depression (CSD), which is associated with migraine with aura and traumatic brain injury. The aim of this study was to investigate whether CGRP gene expression may be induced by experimental CSD in the rat cerebral cortex...
November 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919018/trigeminal-nervous-system-sensitization-by-infraorbital-nerve-injury-enhances-responses-in-a-migraine-model
#17
Midori Toyama, Chiho Kudo, Chikako Mukai, Mika Inoue, Aiko Oyamaguchi, Hiroshi Hanamoto, Mitsutaka Sugimura, Hitoshi Niwa
BACKGROUND: Although the peripheral and central sensitizations of trigeminal nervous system may be one of the important factors of migraine, the precise mechanism is not fully understood. In this study, we examined the influence of the sensitization of the second division of the trigeminal nerve (V2) by chronic constriction injury (CCI) of the infraorbital nerve (ION) on migraine headache, using the capsaicin-induced migraine model. METHODS: Male Sprague-Dawley rats were assigned to four groups: (a) sham surgery and topical-dural vehicle application (Sham + Vehicle) group, (b) CCI-ION and topical-dural vehicle application (CCI-ION + Vehicle) group, (c) sham surgery and topical-dural capsaicin application (Sham + Capsaicin) group, (d) CCI-ION and topical-dural capsaicin application (CCI-ION + Capsaicin) group...
November 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919020/psychosocial-factors-associated-with-migraine-and-tension-type-headache-in-medical-students
#18
Elena R Lebedeva, Natalia R Kobzeva, Denis V Gilev, Nadezhda V Kislyak, Jes Olesen
BACKGROUND: In our previous study of workers, blood donors and medical students, students stood out with a higher 1-year prevalence of migraine (28%) and tension-type headache (TTH) (74%). General factors associated with headache were common for all groups except low physical activity. The hypothesis of this study was therefore that a number of psychosocial factors relating to the personal sphere would better explain the high prevalence of migraine and TTH in students. METHODS: The study population consisted of 1042 students (719 females, 323 males, mean age 20...
November 8, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919016/age-at-menarche-and-risk-of-developing-migraine-or-non-migraine-headaches-by-young-adulthood-a-prospective-cohort-study
#19
Nasim Maleki, Tobias Kurth, Alison E Field
IMPORTANCE: Migraine is a highly prevalent and disabling primary headache disorder that is two to three times more prevalent in young women. Among females, there is a steep increase in incidence from puberty to young adulthood, but the mechanisms for the increase are unknown. OBJECTIVE: To determine if age of menarche is a risk factor for developing migraine headache vs. non-migraine headache by young adulthood. DESIGN: A prospective cohort study, The Growing Up Today Study (GUTS), of adolescents who have been followed since 1996, when they were nine, to 14 years of age...
November 8, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919015/reversible-cerebral-vasoconstriction-syndrome-rcvs-and-headache-attributed-to-aeroplane-travel-ah-does-a-link-exist
#20
EDITORIAL
Federico Mainardi, Ferdinando Maggioni, Giorgio Zanchin
No abstract text is available yet for this article.
November 8, 2016: Cephalalgia: An International Journal of Headache
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