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Cephalalgia: An International Journal of Headache

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https://www.readbyqxmd.com/read/28076964/trigeminal-neuralgia-diagnosis-and-treatment
#1
Stine Maarbjerg, Giulia Di Stefano, Lars Bendtsen, Giorgio Cruccu
Introduction Trigeminal neuralgia (TN) is characterized by touch-evoked unilateral brief shock-like paroxysmal pain in one or more divisions of the trigeminal nerve. In addition to the paroxysmal pain, some patients also have continuous pain. TN is divided into classical TN (CTN) and secondary TN (STN). Etiology and pathophysiology Demyelination of primary sensory trigeminal afferents in the root entry zone is the predominant pathophysiological mechanism. Most likely, demyelination paves the way for generation of ectopic impulses and ephaptic crosstalk...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28068790/temporomandibular-disorders-old-ideas-and-new-concepts
#2
Thomas List, Rigmor Højland Jensen
Background Temporomandibular disorders (TMD) is an umbrella term for pain and dysfunction involving the masticatory muscles and the temporomandibular joints (TMJs). TMD is the most common orofacial pain condition. Its prominent features include regional pain in the face and preauricular area, limitations in jaw movement, and noise from the TMJs during jaw movements. TMD affects up to 15% of adults and 7% of adolescents. Chronic pain is the overwhelming reason that patients with TMD seek treatment. TMD can associate with impaired general health, depression, and other psychological disabilities, and may affect the quality of life of the patient...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28058944/epilepsy-in-hemiplegic-migraine-genetic-mutations-and-clinical-implications
#3
P Prontera, P Sarchielli, S Caproni, C Bedetti, L M Cupini, P Calabresi, C Costa
Objective We performed a systematic review on the comorbidities of familial/sporadic hemiplegic migraine (F/SHM) with seizure/epilepsy in patients with CACNA1A, ATP1A2 or SCN1A mutations, to identify the genotypes associated and investigate for the presence of mutational hot spots. Methods We performed a search in MEDLINE and in the Human Gene Mutation and Leiden Open Variation Databases for mutations in the CACNA1A, ATP1A2 and SCN1A genes. After having examined the clinical characteristics of the patients, we selected those having HM and seizures, febrile seizures or epilepsy...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28058943/genome-wide-analysis-of-blood-gene-expression-in-migraine-implicates-immune-inflammatory-pathways
#4
Zachary F Gerring, Joseph E Powell, Grant W Montgomery, Dale R Nyholt
Background Typical migraine is a frequent, debilitating and painful headache disorder with an estimated heritability of about 50%. Although genome-wide association (GWA) studies have identified over 40 single nucleotide polymorphisms associated with migraine, further research is required to determine their biological role in migraine susceptibility. Therefore, we performed a study of genome-wide gene expression in a large sample of 83 migraine cases and 83 non-migraine controls to determine whether altered expression levels of genes and pathways could provide insights into the biological mechanisms underlying migraine...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28058942/chronic-paroxysmal-headache-secondary-to-an-orbital-metastatic-leiomyosarcoma-a-case-report
#5
Hyun Ah Choi, Mi Ji Lee, Chin-Sang Chung
Background Intraorbital lesions associated with symptomatic trigeminal autonomic cephalalgias (TACs) are rarely reported. We present a case of orbital metastatic leiomyosarcoma, presenting with chronic paroxysmal hemicrania-like headache. Case report A 43-year-old man presented with a severe paroxysmal headache in his left periocular and frontal area for a year. The attacks occurred 10-12 times per day, lasting 10-15 minutes with ipsilateral lacrimation and conjunctival injection. Neurological examination and brain MRI without contrast were unremarkable...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28056534/episodic-status-migrainosus-a-novel-migraine-subtype
#6
Tarun D Singh, F Michael Cutrer, Jonathan H Smith
Objective To report a case series of a novel migraine subtype, which we term as episodic status migrainosus (ESM), characterized by attacks of migraine exclusively lasting more than 72 hours. We hypothesized that this would represent a novel nosologic entity, possibly an unstable migraine phenotype with a high conversion rate to chronic migraine (CM). Methods We conducted a retrospective review of patients diagnosed with status migrainosus at the Mayo Clinic, Rochester, between January 2005 and December 2015...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28056533/hemicrania-continua-in-carotid-artery-dissection-symptomatic-cases-or-linked-pathophysiology
#7
Roland Brilla, Matthias Pawlowski, Stefan Evers
Background Hemicrania continua (HC) -like headaches have been rarely reported as symptomatic headaches, including cases secondary to cervical artery dissection. Case series We present five cases of HC-like headaches following cervical artery dissection, in three cases with specific indomethacin response. In two cases, comorbidity of fibromuscular dysplasia (FMD) was noted. Conclusion Carotid artery dissection may result in an HC-like headache syndrome. A specific response to indomethacin does not rule out dissection as underlying pathology...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27956547/antiepileptic-drugs-in-migraine-and-epilepsy-who-is-at-increased-risk-of-adverse-events
#8
Michele Romoli, Cinzia Costa, Sabrina Siliquini, Ilenia Corbelli, Paolo Eusebi, Chiara Bedetti, Stefano Caproni, Letizia Maria Cupini, Paolo Calabresi, Paola Sarchielli
BACKGROUND: The impact of adverse events (AEs) of antiepileptic drugs (AEDs) have an impact on compliance and dropouts. We compared tolerability of AEs of AEDs among patients with migraine, epilepsy, or both. METHODS: Overall, 335 patients (epilepsy (n = 142), migraine (n = 131), and both (n = 62)), were evaluated with the Liverpool Adverse Events Profile (LAEP) to assess the magnitude, profile and occurrence rate of the AEs of valproate, topiramate, and lamotrigine...
December 12, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27940881/long-term-predictors-of-remission-in-patients-treated-for-medication-overuse-headache-at-a-specialized-headache-center-a-prospective-cohort-study
#9
Jasna J Zidverc-Trajkovic, Tatjana Pekmezovic, Zagorka Jovanovic, Aleksandra Pavlovic, Milija Mijajlovic, Aleksandra Radojicic, Nadezda Sternic
OBJECTIVE: To evaluate long-term predictors of remission in patients with medication-overuse headache (MOH) by prospective cohort study. BACKGROUND: Knowledge regarding long-term predictors of MOH outcome is limited. METHODS: Two hundred and forty MOH patients recruited from 2000 to 2005 were included in a one-year follow-up study and then subsequently followed until 31 December 2013. The median follow-up was three years (interquartile range, three years)...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27940880/cgrp-in-human-models-of-primary-headaches
#10
Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
OBJECTIVE: To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. DISCUSSION: Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27940879/field-testing-of-ichd-3-beta-criteria-of-periictal-headaches-in-patients-with-focal-epilepsy-a-prospective-diary-study
#11
Doris Lieba-Samal, Christian Wöber, Christoph Waiß, Theresa Kastiunig, Matthias Seidl, Nina Mahr, Susanne Aull-Watschinger, Ekaterina Pataraia, Stefan Seidel
BACKGROUND: To date we are lacking prospective data for field testing of ICHD-3 beta criteria for periictal headache (PIH). METHODS: Patients with focal epilepsy diagnosed by means of prolonged video-EEG monitoring completed a paper-pencil diary for three months and recorded seizures and headaches on a daily basis. According to ICHD-3 beta, we classified PIH, defined as headache present on a day with at least one seizure, as "7.6 headache related to epileptic seizure", "7...
December 9, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27927895/in-theory-theory-and-practice-are-the-same-in-practice-they-are-not
#12
LETTER
J Alexander de Ru
No abstract text is available yet for this article.
December 7, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27927894/when-cervical-pain-is-actually-migraine-an-observational-study-in-207-patients
#13
Michele Viana, Grazia Sances, Salvatore Terrazzino, Till Sprenger, Giuseppe Nappi, Cristina Tassorelli
INTRODUCTION: A large proportion of migraine patients remain undiagnosed or misdiagnosed in Italy. In our experience, many migraineurs self-diagnose their condition as "cervical pain attack" or "cervical pain syndrome" (CP), assuming cervical spine pathology as the cause. We aimed to phenotype and classify the headache of patients with self-diagnosed CP, and to describe this sample of patients. METHODS: Consecutive patients aged 18 to 75 years, referred to the Headache Center of the Mondino Institute (Pavia, Italy) for a first visit for headache, completed a questionnaire about CP and were subsequently examined by an experienced clinician...
December 7, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27899434/development-of-cgrp-dependent-pain-and-headache-related-behaviours-in-a-rat-model-of-concussion-implications-for-mechanisms-of-post-traumatic-headache
#14
Dara Bree, Dan Levy
BACKGROUND AND OBJECTIVE: Posttraumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a mild traumatic brain injury, or concussion. However, the mechanisms underlying PTH remain elusive, in part due to the lack of a clinically relevant animal model. Here, we characterized for the first time, headache and pain-related behaviours in a rat model of concussion evoked by a mild closed head injury (mCHI) - the major type of military and civilian related trauma associated with PTH - and tested responses to current and novel headache therapies...
November 29, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27895210/-dr-google-will-see-you-now-time-trends-in-online-searches-on-headache
#15
EDITORIAL
Marcelo D Mendonça, André Caetano, Miguel Viana-Baptista
No abstract text is available yet for this article.
November 28, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27884929/pro-nociceptive-migraine-mediator-cgrp-provides-neuroprotection-of-sensory-cortical-and-cerebellar-neurons-via-multi-kinase-signaling
#16
Polina A Abushik, Geneviève Bart, Paula Korhonen, Hanna Leinonen, Raisa Giniatullina, Dmitry A Sibarov, Anna-Liisa Levonen, Tarja Malm, Sergei M Antonov, Rashid Giniatullin
BACKGROUND: Blocking the pro-nociceptive action of CGRP is one of the most promising approaches for migraine prophylaxis. The aim of this study was to explore a role for CGRP as a neuroprotective agent for central and peripheral neurons. METHODS: The viability of isolated rat trigeminal, cortical and cerebellar neurons was tested by fluorescence vital assay. Engagement of Nrf2 target genes was analyzed by qPCR. The neuroprotective efficacy of CGRP in vivo was tested in mice using a permanent cerebral ischemia model...
November 24, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27881687/bilateral-cisternal-abducens-nerve-involvement-with-ophthalmoplegic-migraine
#17
EDITORIAL
Richa Tripathi, Alexandros Tselis, Evanthia Bernitsas
No abstract text is available yet for this article.
November 23, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27872339/visual-and-auditory-cortical-evoked-potentials-in-interictal-episodic-migraine-an-audit-on-624-patients-from-three-centres-response-to-the-letter-by-omland-et-al
#18
EDITORIAL
Anna Ambrosini, Aliaksei Kisialiou, Jean Schoenen
No abstract text is available yet for this article.
November 21, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27872338/re-visual-and-auditory-cortical-evoked-potentials-in-interictal-episodic-migraine-an-audit-on-624-patients-from-three-centres
#19
EDITORIAL
Petter Moe Omland, Martin Uglem, Lars Jacob Stovner, Trond Sand
No abstract text is available yet for this article.
November 21, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27852962/anatomy-and-immunochemical-characterization-of-the-non-arterial-peptidergic-diffuse-dural-innervation-of-the-rat-and-rhesus-monkey-implications-for-functional-regulation-and-treatment-in-migraine
#20
Frank L Rice, Jennifer Y Xie, Phillip J Albrecht, Emily Acker, Justin Bourgeois, Edita Navratilova, David W Dodick, Frank Porreca
OBJECTIVE: The interplay between neuronal innervation and other cell types underlies the physiological functions of the dura mater and contributes to pathophysiological conditions such as migraine. We characterized the extensive, but understudied, non-arterial diffuse dural innervation (DDI) of the rat and Rhesus monkey. METHODS: We used a comprehensive integrated multi-molecular immunofluorescence labeling strategy to extensively profile the rat DDI and to a lesser extent that of the Rhesus monkey...
November 16, 2016: Cephalalgia: An International Journal of Headache
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