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Cephalalgia: An International Journal of Headache

Pamela Vo, Shihua Wen, Marie-Josée Martel, Dimos Mitsikostas, Uwe Reuter, Jan Klatt
Objective This study evaluated the benefit-risk profile of erenumab relative to other therapies approved for migraine prophylaxis and available in the majority of European countries. Methods Trials were identified via a published systematic literature review updated to December 2017 using MEDLINE. Erenumab's pivotal trials study reports were also included (NCT02066415, NCT02456740). From these sources, ≥ 50% responder rates and discontinuations due to adverse events were extracted to generate numbers needed to treat and harm and likelihood of being helped or harmed, a quantitative benefit-risk measure...
September 19, 2018: Cephalalgia: An International Journal of Headache
Pamela Blake, Roni-Reuven Nir, Carlton J Perry, Rami Burstein
Background The therapeutic benefit of nerve decompression surgeries for chronic headache/migraine are controversial. Aim To provide clinical characteristics of headache type and treatment outcome of occipital nerve decompression surgery. Methods A retrospective review of clinical records. Inclusion criteria were evidence of chronic occipital headache with and without migrainous features and tenderness of neck muscles, occipital allodynia, and inadequate response to prophylactic drugs. Results Surgical decompression of the greater and lesser occipital nerves provided complete and extended (3-6 years) relief of new daily persistent headache in case 3 (46 year old female), and of chronic post-traumatic headache in cases 4 and 6 (35 and 30 year old females, respectively), partial relief of chronic headache/migraine in cases 1 and 2 (41 year old female and 36 year old male), and no relief of episodic (cases 3 and 4) or chronic migraine (case 5, 52 year old male), or chronic tension-type headache (case 7, 31 year old male)...
September 14, 2018: Cephalalgia: An International Journal of Headache
Licia Grazzi, Alberto Raggi, Domenico D'Amico, Emanuela Sansone, Matilde Leonardi, Frank Andrasik, Antonina Gucciardi, Davide Guido, Giovanni D'Andrea
Aim To address whether, in patients with chronic migraine and medication overuse headache, mindfulness-based treatment is associated with changes in plasma levels of catecholamines and elusive amines that are similar to those observed in patients undergoing pharmacological prophylaxis. Methods In this non-randomized, clinic-based effectiveness study, patients aged 18-65, with a history of chronic migraine ≥ 10 years and overuse of triptans or non-steroidal anti-inflammatory drugs ≥ 5 years, were enrolled...
September 13, 2018: Cephalalgia: An International Journal of Headache
David Moreno-Ajona, Ester Moreno-Artero, María Reyes García de Eulate, Pablo Irimia, Agustín España
Background Localized facial scleroderma usually presents as frontal linear morphea or progressive hemifacial atrophy. Only isolated cases of trigeminal painful neuropathy have been described. Case report A 43-year-old woman developed an oval lesion on the right cheek. After 1 year, she noticed constant "pulling" pain and episodes of lancinating pain, both spontaneous and triggered by chewing and cold drinks. She was diagnosed with solitary morphea profunda and CT scan, ultrasonography, cranial MRI and biopsy were completed...
September 13, 2018: Cephalalgia: An International Journal of Headache
Luise Haulund Vollesen, Song Guo, Malene Rohr Andersen, Messoud Ashina
Objective To investigate the effect of the H1 -antihistamine clemastine on the migraine-inducing abilities of pituitary adenylate cyclase activating peptide-38. Methods We conducted a double-blind, randomized, placebo controlled two-way cross-over study. Twenty migraine without aura patients were randomly allocated to receive bolus clemastine 2 mg (1 mg/ml) or bolus saline 2 ml intravenously over 2 min on two study days. Following each bolus injection, 10 pmol/kg/min of pituitary adenylate cyclase activating peptide-38 was administered intravenously over 20 min...
August 30, 2018: Cephalalgia: An International Journal of Headache
Clinton G Lauritsen, Stephen D Silberstein
Background Migraine is a primary headache disorder involving dysregulation of central and peripheral pain pathways. Medical treatment is often limited by drug side effects, comorbidities and poor compliance. This makes neuromodulation an ideal option for migraine treatment. Cefaly® is a transcutaneous electrical neurostimulator designed specifically for migraine treatment. It results in external trigeminal nerve stimulation of the supraorbital and supratrochlear nerves. External trigeminal nerve stimulation is effective for acute and preventive migraine treatment and may result in normalization of dysregulated pain pathways...
August 23, 2018: Cephalalgia: An International Journal of Headache
Natalia L Starikova, Tatiana V Baidina, Tatiana P Kalashnikova
Background The role of thyroid regulation in migraine is poorly understood, and data is contradictory. Objective To study the possible association of clinical features of migraine with patients' thyroid function. Patients and methods One hundred and thirty migraine patients of a tertiary headache center took part in an open-label, cross-sectional comparative study. The Migraine Disability Assessment questionnaire, Spielberger State-Trait Anxiety Inventory, Beck Depression Inventory, Vanderbilt's Questionnaire of Pain Management, Gothenburg Quality of Life Questionnaire and Migraine-Specific Quality of Life questionnaire were used...
August 13, 2018: Cephalalgia: An International Journal of Headache
Ji-Hyung Park, Kyung-Ah Park, Jihoon Cha, Sung Tae Kim, Chin-Sang Chung, Mi Ji Lee
Background Retinal migraine is an important differential diagnosis of recurrent transient monocular blindness accompanied by headache when other etiologies are excluded. Here, we report a case of orbital vasculitis which initially mimicked retinal migraine. Case report A 47-year-old woman had recurrent episodes of fully reversible transient monocular blindness accompanied by ipsilateral headache for 15 months. The patient's neuroimaging and cardiac and ophthalmologic evaluations were normal. With a diagnosis of retinal migraine, her symptoms remitted in response to prophylactic treatment with topiramate and propranolol for 8 months...
August 12, 2018: Cephalalgia: An International Journal of Headache
Marion Strupf, Britta Fraunberger, Karl Messlinger, Barbara Namer
Introduction Migraine is characterized by cycling phases (interictal, preictal, ictal and postictal) with differing symptoms, while in chronic tension type headache pain phases are fluctuating. The question we asked is whether these phases are associated with changes in parameters of somatosensation and axon-reflex erythema. Methods Patients with episodic migraine and chronic tension type headache were examined psychophysically in the interictal, preictal and ictal phase and healthy subjects on five different test days...
August 12, 2018: Cephalalgia: An International Journal of Headache
Jens Fichtner, Christian T Ulrich, Christian Fung, Debora Cipriani, Jan Gralla, Eike Immo Piechowiak, Felix Schlachetzki, Werner J Z'Graggen, Andreas Raabe, Jürgen Beck
Objective Spontaneous intracranial hypotension is caused by spinal cerebrospinal fluid leakage. Patients with orthostatic headaches and cerebrospinal fluid leakage show a decrease in optic nerve sheath diameter upon movement from supine to upright position. We hypothesized that the decrease in optic nerve sheath diameter upon gravitational challenge would cease after closure of the leak. Methods We included 29 patients with spontaneous intracranial hypotension and refractory symptoms admitted from 2013 to 2016...
August 12, 2018: Cephalalgia: An International Journal of Headache
Arnaud Pellerin, Clémence Marois, Nicolas Mezouar, Karima Mokhtari, Delphine Leclercq, Bruno Law-Ye
Background Magnetic resonance imaging abnormalities in hemiplegic migraine have been described previously but were limited to a cortical thickening and biphasic alternation of hypoperfusion and hyperperfusion. Our report reveals possible blood-brain barrier disruption during migraine. Case We present the first demonstrated case of regressive diffuse hemispheric cortical enhancement in sporadic hemiplegic migraine, with histological correlation revealing neuronal lesions similar to ischemic lesions. This is probably due to the severity of the attack as indicated by the left hemiplegia and transient altered consciousness in our 43-year-old male patient...
August 9, 2018: Cephalalgia: An International Journal of Headache
Franziska Guenther, Ferdinand Swozil, Stefan Heber, Michael Buchfelder, Karl Messlinger, Michael Jm Fischer
Background Meningiomas are generally slowly growing intracranial tumors. They are often incidentally diagnosed, given that symptoms may be absent even in cases of an enormous tumor size. Headache is a frequent but not consistent symptom. Therefore, we examined the association between structural, biochemical and histochemical tumor parameters with preoperative as well as postoperative occurrence of headache. Methods In our study, we prospectively investigated 69 consecutive patients enrolled for meningioma neurosurgery...
August 8, 2018: Cephalalgia: An International Journal of Headache
Marie Deen, Anders Hougaard, Hanne D Hansen, Claus Svarer, Hans Eiberg, Szabolcs Lehel, Gitte M Knudsen, Messoud Ashina
Introduction Serotonin (5-HT) plays a role in migraine pathophysiology, but whether brain 5-HT is involved in the conversion from episodic to chronic migraine is unknown. Here, we investigated brain 5-HT levels, as indexed by 5-HT4 receptor binding, in chronic migraine patients and evaluated whether these were associated with migraine frequency. Methods Sixteen chronic migraine patients underwent a dynamic PET scan after injection of [11 C]SB207145, a specific 5-HT4 receptor radioligand. Data from 15 episodic migraine patients and 16 controls were included for comparison...
August 8, 2018: Cephalalgia: An International Journal of Headache
Yuan Wang, Qian Yang, Dongyuan Cao, David Seminowicz, Bethany Remeniuk, Lin Gao, Ming Zhang
Background Recent neuroimaging studies have reported grey matter alterations in primary trigeminal neuralgia patients. However, few studies have focused on quantitative measurements of trigeminal nerves and the interaction between trigeminal nerve volume and brain morphology, particularly grey matter volume. In this study, we investigated the link between trigeminal nerves and grey matter volume changes in primary trigeminal neuralgia patients compared to healthy controls. Moreover, we explored the association of structure of trigeminal nerves and grey matter to collected pain clinical variables...
August 7, 2018: Cephalalgia: An International Journal of Headache
Hiroaki Matsumoto, Hiroaki Hanayama, Yasuo Sakurai, Hiroaki Minami, Atsushi Masuda, Shogo Tominaga, Katsuya Miyaji, Ikuya Yamaura, Yasuhisa Yoshida, Yutaka Hirata
Background and purpose It is sometimes difficult to diagnose intracranial vertebral artery dissection in patients with headache as the only symptom. Knowledge of the characteristics of the headache would facilitate the diagnosis. In this study, we aimed to clarify the characteristics of intracranial vertebral artery dissection-related headache using our original self-administered questionnaire. Methods Via the questionnaire, we ascertained headache characteristics and investigated whether they differed between two types of unruptured intracranial vertebral artery dissection, headache type and ischemic type, based on analysis of the responses...
August 6, 2018: Cephalalgia: An International Journal of Headache
Lucia Albers, Rüdiger von Kries, Andreas Straube, Florian Heinen, Viola Obermeier, Mirjam N Landgraf
Objective To assess the relative risk, predictive value and population attributable risk fraction of pre-school episodic syndromes for later migraine in primary school age children. Methods This retrospective cohort study used health insurance data on 55,035 children born in 2006 with no diagnosis of migraine up to the age of 5 years. The relative risk, probability and population attributable risk fraction of migraine prompting a physician visit at the age of 6-10 years in children with episodic syndromes included in the International Classification of Headache Disorders (benign paroxysmal torticollis, benign paroxysmal vertigo, cyclic vomiting syndrome, recurrent abdominal symptoms and abdominal migraine) and those not included in the International Classification of Headache Disorders (pavor nocturnus, somnabulism and bruxism) diagnosed up to the age of 5 years were determined...
August 4, 2018: Cephalalgia: An International Journal of Headache
Samaira Younis, Anders Hougaard, Rodrigo Noseda, Messoud Ashina
Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target...
August 4, 2018: Cephalalgia: An International Journal of Headache
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September 2018: Cephalalgia: An International Journal of Headache
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September 2018: Cephalalgia: An International Journal of Headache
Matthew Sussman, Jennifer Benner, Peter Neumann, Joseph Menzin
Objectives To assess the cost-effectiveness of erenumab 140 mg ("erenumab") for the prophylactic treatment of episodic migraine and chronic migraine. Study design A hybrid Monte Carlo patient simulation and Markov cohort model was constructed to compare erenumab to no preventive treatment or onabotulinumtoxinA among adult ( ≥ 18 years) patients with episodic migraine and chronic migraine who failed prior preventive therapy from the US societal and payer perspectives. Methods Patients entered the model one at a time and were assigned to a post-treatment monthly migraine day category based on baseline monthly migraine days and treatment effect...
September 2018: Cephalalgia: An International Journal of Headache
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