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Cephalalgia: An International Journal of Headache

Raimundo Pereira Silva-Néto, Ânderson Batista Rodrigues, Dandara Coelho Cavalcante, Pedro Henrique Piauilino Benvindo Ferreira, Ema Pereira Nasi, Kamila Maria de Holanda Sousa, Adriana Almeida Soares, Mário Fernando Pietro Peres, Marcelo Moraes Valença
No abstract text is available yet for this article.
August 2017: Cephalalgia: An International Journal of Headache
Gakuji Gondo, Tsuyoshi Watanabe, Junya Kawada, Masahiko Tanaka, Kazuaki Yamamoto, Satoshi Tanaka, Satoshi Endo
Introduction We report a case of cervicogenic headache caused by an intradural extramedullary tumor of the middle cervical spine, which has not previously been reported. Case presentation The patient was a 73-year-old male who visited a physician for a chief complaint of pain from the left lower jaw to the auricle and occipital region. The headache was induced with retroflexion of the neck. On cervical magnetic resonance imaging, an intradural extramedullary tumor was noted on the left side at the C4/5 level...
August 2017: Cephalalgia: An International Journal of Headache
Federico Mainardi, Ferdinando Maggioni, Giorgio Zanchin
No abstract text is available yet for this article.
August 2017: Cephalalgia: An International Journal of Headache
Delphine Magis, Kevin D'Ostilio, Aurore Thibaut, Victor De Pasqua, Pascale Gerard, Roland Hustinx, Steven Laureys, Jean Schoenen
Background and aim A recent sham-controlled trial showed that external trigeminal nerve stimulation (eTNS) is effective in episodic migraine (MO) prevention. However, its mechanism of action remains unknown. We performed 18-fluorodeoxyglucose positron emission tomography (FDG-PET) to evaluate brain metabolic changes before and after eTNS in episodic migraineurs. Methods Twenty-eight individuals were recruited: 14 with MO and 20 healthy volunteers (HVs). HVs underwent a single FDG-PET, whereas patients were scanned at baseline, directly after a first prolonged session of eTNS (Cefaly®) and after three months of treatment (uncontrolled study)...
August 2017: Cephalalgia: An International Journal of Headache
Peer Carsten Tfelt-Hansen
Background In most pharmacokinetic studies, the oral absorption of drugs is impaired during migraine attacks but exceptions occur. A study on gastric emptying using gastric scintigraphy indicated that gastric stasis also occurs interictally in migraine. These studies were reviewed critically. Results In seven studies, mainly investigating NSAIDs and analgesics, the early absorption of the drugs during 112 migraine attacks was delayed. The absorption of sumatriptan is usual in therapeutic doses, and rizatriptan was normal during 131 migraine attacks...
August 2017: Cephalalgia: An International Journal of Headache
Charly Gaul, Jana Roguski, Thomas Dresler, Hind Abbas, Andreas Totzeck, Klaus Görlinger, Hans-Christoph Diener, Ralph Weber
Background Treatment options for cluster headache (CH) include acute, transitional and prophylactic strategies. We assessed the efficacy and safety of a single occipital nerve block (ONB) in patients with episodic (eCH) and chronic CH (cCH). Methods In this prospective, observational study 101 CH were treated with a single ONB using triamcinolone 10 mg and bupivacaine. Attack frequency, pain intensity and side effects were assessed at days 1 and 7 after ONB and thereafter weekly for 60 days until recurrence of attacks...
August 2017: Cephalalgia: An International Journal of Headache
Catherine D Chong, Nathan Gaw, Yinlin Fu, Jing Li, Teresa Wu, Todd J Schwedt
Background This study used machine-learning techniques to develop discriminative brain-connectivity biomarkers from resting-state functional magnetic resonance neuroimaging ( rs-fMRI) data that distinguish between individual migraine patients and healthy controls. Methods This study included 58 migraine patients (mean age = 36.3 years; SD = 11.5) and 50 healthy controls (mean age = 35.9 years; SD = 11.0). The functional connections of 33 seeded pain-related regions were used as input for a brain classification algorithm that tested the accuracy of determining whether an individual brain MRI belongs to someone with migraine or to a healthy control...
August 2017: Cephalalgia: An International Journal of Headache
Kai I Müller, Karl B Alstadhaug, Svein I Bekkelund
Objectives We determined headache patients' satisfaction with telemedicine and assessed how telemedicine influenced headache burden, compliance with diagnosis and treatment, and need for follow-up consultations. Methods During 2.5 years, patients from Northern Norway referred with non-acute headaches for a specialist consultation at Tromsø University Hospital were consecutively randomised to either telemedicine or traditional visits. Baseline data were recorded and compared to data from a three-month follow-up questionnaire (see Supplementary material)...
August 2017: Cephalalgia: An International Journal of Headache
María L Cuadrado, Ángel Aledo-Serrano, Patricia Navarro, Pedro López-Ruiz, César Fernández-de-Las-Peñas, Inés González-Suárez, Aida Orviz, Cristina Fernández-Pérez
Background Greater occipital nerve (GON) blocks are widely used for the treatment of headaches, but quality evidence regarding their efficacy is scarce. Objective The objective of this article is to assess the short-term clinical efficacy of GON anaesthetic blocks in chronic migraine (CM) and to analyse their effect on pressure pain thresholds (PPTs) in different territories. Participants and methods The study was designed as a double-blind, randomised, placebo-controlled clinical trial. Thirty-six women with CM were treated either with bilateral GON block with bupivacaine 0...
August 2017: Cephalalgia: An International Journal of Headache
Tae-Jin Song, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu
Background Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population. Methods We recruited Korean individuals aged 19-69 years via stratified random sampling and assessed headache type, anxiety, and depression among them using structured interviews. Results In a representative sample of 2695 individuals, 143 (5...
August 2017: Cephalalgia: An International Journal of Headache
N Riesco, E Cernuda-Morollón, P Martínez-Camblor, A I Pérez-Alvarez, L Verano, C García-Cabo, E Serrano-Pertierra, J Pascual
Background Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine chronification. Objective The objective of this article is to correlate the presence of CAPS with serum levels of vasoactive intestinal peptides (VIP) and calcitonin gene-related peptide (CGRP). Patients and methods Patients with chronic migraine (CM) were asked about the presence - during migraine attacks - of five CAPS, which were scored from 0 to 10 by using a quantitative scale...
August 2017: Cephalalgia: An International Journal of Headache
Melissa M Cortez, Natalie A Rea, Lindsay A Hunter, Kathleen B Digre, K C Brennan
Background Autonomic dysfunction and light sensitivity are core features of the migraine attack. Growing evidence also suggests changes in these parameters between attacks. Though sensory and autonomic responses likely interact, they have not been studied together across the spectrum of disease in migraine. Methods We performed digital infrared pupillometry while collecting interictal photophobia thresholds (PPT) in 36 migraineurs (14 episodic; 12 chronic; 10 probable) and 24 age and sex-matched non-headache controls...
July 2017: Cephalalgia: An International Journal of Headache
Inge H Palm-Meinders, Hille Koppen, Gisela M Terwindt, Lenore J Launer, Mark A van Buchem, Michel D Ferrari, Mark C Kruit
Introduction In the CAMERA population-based MRI study, migraineurs below the age of 50 had decreased T2-values indicative of increased iron deposition in several deep brain nuclei. Longer migraine history was associated with lower T2-values, suggesting an association between migraine attacks and iron accumulation. In the present nine-year follow-up study of the CAMERA cohort we re-measured the T2-values in deep brain nuclei to assess the evolution over time. Methods Baseline and follow-up T2-values measured in several basal ganglia of 128 participants (38 control, 90 migraine) were analyzed using quantitative T2 measurements and multivariate regression analysis...
July 2017: Cephalalgia: An International Journal of Headache
Jennifer Y Xie, Milena De Felice, Caroline M Kopruszinski, Nathan Eyde, Justin LaVigne, Bethany Remeniuk, Pablo Hernandez, Xu Yue, Naomi Goshima, Michael Ossipov, Tamara King, John M Streicher, Edita Navratilova, David Dodick, Hugh Rosen, Ed Roberts, Frank Porreca
Background Stress is the most commonly reported migraine trigger. Dynorphin, an endogenous opioid peptide acting preferentially at kappa opioid receptors (KORs), is a key mediator of stress responses. The aim of this study was to use an injury-free rat model of functional cephalic pain with features of migraine and medication overuse headache (MOH) to test the possible preventive benefit of KOR blockade on stress-induced cephalic pain. Methods Following sumatriptan priming to model MOH, rats were hyper-responsive to environmental stress, demonstrating delayed cephalic and extracephalic allodynia and increased levels of CGRP in the jugular blood, consistent with commonly observed clinical outcomes during migraine...
July 2017: Cephalalgia: An International Journal of Headache
María L Cuadrado, Ángel Aledo-Serrano, Pedro López-Ruiz, Álvaro Gutiérrez-Viedma, Cristina Fernández, Aida Orviz, José A Arias
Background Presently, there is no evidence to guide the acute treatment of migraine aura. We aimed to describe the effect of greater occipital nerve (GON) anaesthetic block as a symptomatic treatment for long-lasting (prolonged or persistent) migraine aura. Methods Patients who presented with migraine aura lasting > 2 hours were consecutively recruited during one year at the Headache Unit and the Emergency Department of a tertiary hospital. All patients underwent a bilateral GON block with bupivacaine 0...
July 2017: Cephalalgia: An International Journal of Headache
Lars Michels, Foteini Christidi, Vivian R Steiger, Peter S Sándor, Andreas R Gantenbein, Gunther Landmann, Sebastian R Schreglmann, Spyros Kollias, Franz Riederer
Background Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders. Methods In this cross-sectional study, we investigated functional connectivity (FC) with resting-state functional magnetic resonance imaging (fMRI) and white matter integrity using diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) and mean diffusivity (MD) in patients with MOH ( N = 12) relative to two control groups: patients with chronic myofascial pain (MYO; N = 11) and healthy controls (CN; N = 16)...
July 2017: Cephalalgia: An International Journal of Headache
Massimo Leone, Alberto Proietti Cecchini, Giuseppe Messina, Angelo Franzini
Introduction Chronic cluster headache is rare and some of these patients become drug-resistant. Occipital nerve stimulation has been successfully employed in open studies to treat chronic drug-resistant cluster headache. Data from large group of occipital nerve stimulation-treated chronic cluster headache patients with long duration follow-up are advantageous. Patients and methods Efficacy of occipital nerve stimulation has been evaluated in an experimental monocentric open-label study including 35 chronic drug-resistant cluster headache patients (mean age 42 years; 30 men; mean illness duration: 6...
July 2017: Cephalalgia: An International Journal of Headache
N Pelzer, D E Blom, A H Stam, L S Vijfhuizen, Atm Hageman, J A van Vliet, M D Ferrari, Amjm van den Maagdenberg, J Haan, G M Terwindt
Background Familial hemiplegic migraine (FHM) is a rare monogenic migraine subtype characterised by attacks associated with transient motor weakness. Clinical information is mainly based on reports of small families with only short follow-up. Here, we document a prospective 15-year follow-up of an extended family with FHM type 2. Patients and methods After diagnosing FHM in a patient with severe attacks associated with coma and fever, we identified eight more family members with FHM and one with possible FHM...
July 2017: Cephalalgia: An International Journal of Headache
Ottar Sjaastad
No abstract text is available yet for this article.
July 2017: Cephalalgia: An International Journal of Headache
Aneesh B Singhal, Matthew B Maas, Joshua N Goldstein, Brittany B Mills, David W Chen, Cenk Ayata, Robert M Kacmarek, Mehmet A Topcuoglu
Background Impaired oxygen utilization and cerebrovascular dysfunction are implicated in migraine. High-flow oxygen is effective in cluster headache and has shown promise in animal models of migraine, but has not been adequately studied in patients with migraine. Methods In this randomized, crossover-design, placebo-controlled trial, adult migraineurs self-administered high-flow oxygen or medical air at 10-15 l/min via face mask in blinded fashion starting soon after symptom onset for 30 minutes, for a total of four migraine attacks...
July 2017: Cephalalgia: An International Journal of Headache
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