journal
MENU ▼
Read by QxMD icon Read
search

Cellular and Molecular Neurobiology

journal
https://www.readbyqxmd.com/read/28639079/autonomic-nervous-system-response-to-stressors-in-newly-diagnosed-patients-with-multiple-sclerosis
#1
Miroslav Vlcek, Adela Penesova, Richard Imrich, Milada Meskova, Martina Mravcova, Lucia Grunnerova, Alexandra Garafova, Monika Sivakova, Peter Turcani, Branislav Kollar, Daniela Jezova
Autonomic dysfunction is commonly detected in patients with multiple sclerosis (MS). However, data evaluating autonomic nervous system function in early MS are limited. Present study investigates response to two different stressors in newly diagnosed MS patients, looking for the signs of autonomic dysfunction at the beginning of the disease. We examined 19 MS patients and 19 age, sex, and body mass index matched healthy controls. MS patients were newly diagnosed, untreated, and with low expanded disability status scale (EDSS) values [median 1...
June 21, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28639078/a-genome-wide-expression-association-analysis-identifies-genes-and-pathways-associated-with-amyotrophic-lateral-sclerosis
#2
Yanan Du, Yan Wen, Xiong Guo, Jingcan Hao, Wenyu Wang, Awen He, Qianrui Fan, Ping Li, Li Liu, Xiao Liang, Feng Zhang
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with strong genetic components. To identity novel risk variants for ALS, utilizing the latest genome-wide association studies (GWAS) and eQTL study data, we conducted a genome-wide expression association analysis by summary data-based Mendelian randomization (SMR) method. Summary data were derived from a large-scale GWAS of ALS, involving 12577 cases and 23475 controls. The eQTL annotation dataset included 923,021 cis-eQTL for 14,329 genes and 4732 trans-eQTL for 2612 genes...
June 21, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28623429/bdnf-a-key-factor-with-multipotent-impact-on-brain-signaling-and-synaptic-plasticity
#3
REVIEW
Przemysław Kowiański, Grażyna Lietzau, Ewelina Czuba, Monika Waśkow, Aleksandra Steliga, Janusz Moryś
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and modulation of both short- and long-lasting synaptic interactions, which are critical for cognition and memory. A wide spectrum of processes are controlled by BDNF, and the sometimes contradictory effects of its action can be explained based on its specific pattern of synthesis, comprising several intermediate biologically active isoforms that bind to different types of receptor, triggering several signaling pathways...
June 16, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28623428/quantitative-measurement-of-pard3-copy-number-variations-in-human-neural-tube-defects
#4
Yonghui Gao, Jianhua Wang, Shaofang Shangguan, Yihua Bao, Xiaoli Lu, Jizhen Zou, Yaohua Dai, Junling Liu, Ting Zhang
Although more than 200 genes are known to be related to neural tube defects (NTDs), the exact molecular basis is still unclear. Evaluating the contribution of copy number variation (CNV) might be a priority because CNV involves changes in the copy number of large segments of DNA, leading to phenotypic traits and disease susceptibility. Recent studies have documented that the polarity protein partitioning defective 3 homolog (Pard3) plays an essential role in the process of neural tube closure. The aim of this study was to assess the role of PARD3 CNVs in the etiology of human NTDs...
June 16, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28608001/anti-zn-2-toxicity-of-4-hydroxybenzyl-alcohol-in-astrocytes-and-neurons-contribute-to-a-robust-neuroprotective-effects-in-the-postischemic-brain
#5
Lidan Luo, Seung-Woo Kim, Hye-Kyung Lee, Il-Doo Kim, Hahnbie Lee, Ja-Kyeong Lee
4-Hydroxybenzyl alcohol (4-HBA) is an important phenolic constituent of Gastrodia elata (GE) Blume, which is used as a traditional herbal medicine in East Asia. Many activities have been reported to underlie the beneficial effects of 4-HBA in brain, such as, anti-oxidative, anti-inflammatory, anti-excitotoxic, and anti-apoptotic effects in neurons and microglia. Here, the authors demonstrate the robust neuroprotective effects of 4-HBA in rat middle cerebral artery occlusion (MCAO) model of stroke, and showed anti-Zn(2+) toxicity in neurons and astrocytes as a molecular mechanism contributing to these effects...
June 12, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28608000/crhr1-mediates-the-up-regulation-of-synapsin-i-induced-by-nesfatin-1-through-erk-1-2-signaling-in-sh-sy5y-cells
#6
Zheng Chen, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
The anorexigenic molecule nesfatin-1 has recently been taken as a potential mood regulator, but the potential mechanisms remain unknown. Results of our previous study have demonstrated that nesfatin-1 could induce anxiety- and depression-like behaviors in rats, accompanied by the hyperactivity of the hypothalamic-pituitary-adrenal axis and the imbalanced mRNA expression of synaptic vesicle proteins. To explore the potential neurobiological mechanism underlying the effect of nesfatin-1 on the synaptic plasticity, the human neuroblastoma SH-SY5Y cells were cultured and treated with different concentrations of nesfatin-1 in the present study...
June 12, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28600709/cysteinyl-leukotriene-receptor-antagonists-inhibit-migration-invasion-and-expression-of-mmp-2-9-in-human-glioblastoma
#7
Pannaree Piromkraipak, Kant Sangpairoj, Wuttipong Tirakotai, Kulathida Chaithirayanon, Supeenun Unchern, Porntip Supavilai, Christopher Power, Pornpun Vivithanaporn
Glioblastoma is one of the most malignant and aggressive types of brain tumors. 5-lipoxygenase and cysteinyl leukotriene receptor 1 (CysLT1) play a role in human carcinogenesis. Leukotriene receptor antagonists (LTRAs), anti-asthmatic drugs with mild side effects, have anti-metastatic activity in epidermoid carcinoma, lung carcinoma, and colon cancers as well as neuroprotective effects. Herein, anti-migratory effects of two LTRAs, montelukast and zafirlukast, were investigated in glioblastoma cells. The level of CysLT1 in A172 cells was increased by 3...
June 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28560556/shear-stress-induces-phenotypic-modulation-of-vascular-smooth-muscle-cells-via-ampk-mtor-ulk1-mediated-autophagy
#8
Liqian Sun, Manman Zhao, Aihua Liu, Ming Lv, Jingbo Zhang, Youxiang Li, Xinjian Yang, Zhongxue Wu
Phenotypic modulation of vascular smooth muscle cells (VSMCs) is involved in the pathophysiological processes of the intracranial aneurysms (IAs). Although shear stress has been implicated in the proliferation, migration, and phenotypic conversion of VSMCs, the molecular mechanisms underlying these events are currently unknown. In this study, we investigated whether shear stress(SS)-induced VSMC phenotypic modulation was mediated by autophagy involved in adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/Unc-51-like kinase 1 (ULK1) pathway...
May 30, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28534246/microglia-housekeeper-of-the-central-nervous-system
#9
REVIEW
John Alimamy Kabba, Yazhou Xu, Handson Christian, Wenchen Ruan, Kitchen Chenai, Yun Xiang, Luyong Zhang, Juan M Saavedra, Tao Pang
Microglia, of myeloid origin, play fundamental roles in the control of immune responses and the maintenance of central nervous system homeostasis. These cells, just like peripheral macrophages, may be activated into M1 pro-inflammatory or M2 anti-inflammatory phenotypes by appropriate stimuli. Microglia do not respond in isolation, but form part of complex networks of cells influencing each other. This review addresses the complex interaction of microglia with each cell type in the brain: neurons, astrocytes, cerebrovascular endothelial cells, and oligodendrocytes...
May 22, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28493234/exploration-of-involved-key-genes-and-signaling-diversity-in-brain-tumors
#10
REVIEW
Mojdeh Mahdian Nasser, Parvin Mehdipour
Brain tumors are becoming a major cause of death. The classification of brain tumors has gone through restructuring with regard to some criteria such as the presence or absence of a specific genetic alteration in the 2016 central nervous system World Health Organization update. Two categories of genes with a leading role in tumorigenesis and cancer induction include tumor suppressor genes and oncogenes; tumor suppressor genes are inactivated through a variety of mechanisms that result in their loss of function...
May 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28493233/neurite-outgrowth-stimulated-by-oxytocin-is-modulated-by-inhibition-of-the-calcium-voltage-gated-channels
#11
M Zatkova, A Reichova, Z Bacova, V Strbak, A Kiss, J Bakos
Neuropeptide oxytocin contributes to the regulation of the neuron differentiation and cell morphology. However, the precise mechanisms are not yet fully understood. Oxytocin receptor function and its coupling to calcium entry are obvious objects of interest in relation to the neuron morphology. Postsynaptic scaffolding proteins including SHANK proteins interact with other synaptic molecules and change dendritic morphology. SH-SY5Y neuroblastoma cell line represents a useful neurobiological in vitro model to study the short-term oxytocin effects on neurite outgrowth and underlying mechanisms...
May 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28488010/neuroprotective-effect-of-oxysophocarpine-by-modulation-of-mapk-pathway-in-rat-hippocampal-neurons-subject-to-oxygen-glucose-deprivation-and-reperfusion
#12
Peng Zhao, Ren-Yuan Chang, Ning Liu, Jing Wang, Ru Zhou, Xue Qi, Yue Liu, Lin Ma, Yang Niu, Tao Sun, Yu-Xiang Li, Yan-Ping He, Jian-Qiang Yu
Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced by oxygen and glucose deprivation (OGD) in neonatal rat primary-cultured hippocampal neurons and its mechanisms were investigated. Cultured hippocampal neurons, which were exposed to OGD for 2 h followed by a 24 h reoxygenation, were used as an in vitro model of ischemia and reperfusion...
May 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28488009/linking-stress-catecholamine-autotoxicity-and-allostatic-load-with-neurodegenerative-diseases-a-focused-review-in-memory-of-richard-kvetnansky
#13
REVIEW
David S Goldstein, Irwin J Kopin
In this Focused Review, we provide an update about evolving concepts that may link chronic stress and catecholamine autotoxicity with neurodegenerative diseases such as Parkinson's disease. Richard Kvetnansky's contributions to the field of stress and catecholamine systems inspired some of the ideas presented here. We propose that coordination of catecholaminergic systems mediates adjustments maintaining health and that senescence-related disintegration of these systems leads to disorders of regulation and to neurodegenerative diseases such as Parkinson's disease...
May 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28488008/ameliorating-the-effect-of-pioglitazone-on-lps-induced-inflammation-of-human-oligodendrocyte-progenitor-cells
#14
Maryam Peymani, Kamran Ghaedi, Motahare-Sadat Hashemi, Ali Ghoochani, Abbas Kiani-Esfahani, Mohammad Hossein Nasr-Esfahani, Hossein Baharvand
Oligodendrocyte progenitor cells (OPCs) are appropriate model cells for studying the progress of neurodegenerative disorders and evaluation of pharmacological efficacies of small molecules for treatment of these disorders. Here, we focused on the therapeutic role of Pioglitazone, which is a selective agonist of peroxisome proliferator-activated receptor gamma (PPARγ), a respective nuclear receptor in inflammatory responses. Human embryonic stem cell-derived OPCs were pretreated by Pioglitazone at differing concentrations...
May 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28488007/effects-of-rat-anti-mouse-interleukin-6-receptor-antibody-on-the-recovery-of-cognitive-function-in-stroke-mice
#15
Jun Wei, Chongling Sun, Chang Liu, Qimei Zhang
This study aimed to investigate the effects of rat anti-mouse interleukin (IL)-6 receptor antibody (MR16-1) on the recovery of cognitive function in stroke mice. Adult male C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAO). Mice were randomly assigned into three groups: sham group, model group, and MR16-1 group. After the treatment of MR16-1, spatial learning and memory performance of mice were evaluated by the Morris water maze (MWM) and Y-maze tests. Then, brain slices were obtained and infarct volume and neuronal apoptosis were assessed by 2,3,5-triphenyltetrazolium chloride (TTC) staining and Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, respectively...
May 9, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28484859/effects-of-sdf-1-cxcr4-on-the-repair-of-traumatic-brain-injury-in-rats-by-mediating-bone-marrow-derived-mesenchymal-stem-cells
#16
Quan-Jun Deng, Xiao-Feng Xu, Jing Ren
Our study aims to investigate the effects of the SDF-1/CXCR4 axis on the repair of traumatic brain injury (TBI) in rats by mediating bone marrow derived from mesenchymal stem cells (BMSCs). Healthy male SD rats were collected, their tibiofibulars were removed, cultured, and BMSCs were collected. The expression of cell-surface molecular proteins was examined using flow cytometry. The mRNA and protein expression of CXCR4 in cells were tested using qRT-PCR and western blotting analysis. An electronic brain injury instrument was utilized to build TBI rat models and each rat was assigned into the experiment, positive control and control groups (10 rats in each group)...
May 8, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28478572/perinatal-exposure-to-western-diet-programs-autonomic-dysfunction-in-the-male-offspring
#17
Snigdha Mukerjee, Yun Zhu, Andrea Zsombok, Franck Mauvais-Jarvis, Jinying Zhao, Eric Lazartigues
Although the deleterious influence of protein deficiency on fetal programming is well documented, the impact of a Western diet on epigenetic mechanisms is less clear. We hypothesized that high-fat high-sucrose diet (HFHSD) consumption during pregnancy leads to epigenetic modifications within the progeny's compensatory renin-angiotensin system (RAS), affecting autonomic and metabolic functions. Dams were fed HFHSD (45% fat and 30% sucrose) or regular chow (RD) from mating until weaning of the pups (~7 weeks)...
May 6, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28477054/neuroprotective-effects-of-sigesbeckia-pubescens-extract-on-glutamate-induced-oxidative-stress-in-ht22-cells-via-downregulation-of-mapk-caspase-3-pathways
#18
Md Rashedunnabi Akanda, Myung-Jin Kim, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Md Mahfujur Rahman, Yang-Gyu Park, Jae-Won Seol, Hyeon-Hwa Nam, Byung-Kil Choo, Byung-Yong Park
Sigesbeckia pubescens (SP) is a traditional Chinese medicine, possessing antioxidant and anti-inflammatory activities. In this study, we evaluate the neuroprotective activities of SP extract on glutamate-induced oxidative stress in HT22 cells and the molecular mechanism underlying neuroprotection. We applied 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), crystal violet, reactive oxygen species (ROS), lactate dehydrogenase (LDH), quantitative real-time polymerase chain reaction (qPCR), and western blot analyses for assessing the neuroprotective effects of SP extract...
May 5, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28474296/erratum-to-microrna-29c-pten-pathway-is-involved-in-mice-brain-development-and-modulates-neurite-outgrowth-in-pc12-cells
#19
Hongjun Zou, Ya Ding, Weifeng Shi, Xu Xu, Aihua Gong, Zhijian Zhang, Jinbo Liu
No abstract text is available yet for this article.
May 4, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28470537/erratum-to-o-glcnac-glycosylation-of-nnos-promotes-neuronal-apoptosis-following-glutamate-excitotoxicity
#20
Rongrong Chen, Peipei Gong, Tao Tao, Yilu Gao, Jianhong Shen, Yaohua Yan, Chengwei Duan, Jun Wang, Xiaojuan Liu
No abstract text is available yet for this article.
May 3, 2017: Cellular and Molecular Neurobiology
journal
journal
28271
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"