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Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas

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https://www.readbyqxmd.com/read/30183974/captopril-alleviates-hypertension-induced-renal-damage-inflammation-and-nf-%C3%AE%C2%BAb-activation
#1
Zhongyuan Gan, Dan Huang, Jiaye Jiang, Yuan Li, Hanqing Li, Yan Ke
Hypertensive renal damage generally occurs during the middle and late stages of hypertension, which is typically characterized by proteinuria and renal inflammation. Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been widely used for therapy of arterial hypertension and cardiovascular diseases. However, the protective effects of captopril on hypertension-induced organ damage remain elusive. The present study was designed to explore the renoprotective action of captopril in spontaneously hypertensive rats (SHR)...
September 3, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156596/relationship-between-heart-rate-variability-and-subclinical-thyroid-disorders-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#2
É J F Peixoto de Miranda, R A Hoshi, M S Bittencourt, A C Goulart, I S Santos, A R Brunoni, M F H S Diniz, A L P Ribeiro, E M Dantas, J G Mill, P A Lotufo, I M Benseñor
The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels...
August 27, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156611/gastrodin-induced-ho-1-and-nrf2-up-regulation-to-alleviate-h2o2-induced-oxidative-stress-in-mouse-liver-sinusoidal-endothelial-cells-through-p38-mapk-phosphorylation
#3
Hongbin Zhang, Bo Yuan, Hanfei Huang, Siming Qu, Shikun Yang, Zhong Zeng
Nuclear factor erythroid-related factor 2 (Nrf2) has been implicated in several detoxifying and antioxidant defense processes. Nrf2-mediated heme oxygenase-1 (HO-1) expression was demonstrated to play a key role against oxidative stress. Gastrodin (GSTD) is a well-known active compound isolated from the roots of Rhizoma gastrodiae, a plant used in ancient Chinese traditional medicine. The aim of this work was to investigate whether GSTD could alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells (LSECs)...
August 16, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156610/the-aminoglycoside-antibiotic-gentamicin-is-able-to-alter-metabolic-activity-and-morphology-of-mdck-c11-cells-a-cell-model-of-intercalated-cells
#4
A G G Coutinho, S M P Biscaia, R Fernandez, A L Tararthuch
It is well known that the aminoglycoside antibiotic gentamicin is capable of causing damage to kidney cells. Given the known involvement of Ca2+ in the nephrotoxic action of gentamicin, the purpose of this study was to establish a relationship between the concentration of intracellular Ca2+ ([Ca2+]i) and cellular cytotoxicity using MDCK-C11 cells, a clone that has several properties that resemble those of intercalated cells of the distal nephron. Changes in [Ca2+]i was determined using fluorescence microscopy...
August 16, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156609/knockdown-of-long-non-coding-rna-anril-inhibits-tumorigenesis-in-human-gastric-cancer-cells-via-microrna-99a-mediated-down-regulation-of-bmi1
#5
Pei Liu, Mingming Zhang, Qinghui Niu, Fengjuan Zhang, Yuling Yang, Xiangjun Jiang
Long non-coding RNA antisense non-coding RNA in the INK4 locus (ANRIL) has been reported to promote tumorigenesis via regulating microRNA (miR)-99a in gastric cancer cells. However, the role of each component involved in it is still not well understood. This study aimed to verify the role of ANRIL in gastric cancer as well as the underlying mechanisms. ANRIL levels in clinical gastric cancer tissues and cell lines were tested by qPCR. Effects of ANRIL silence on cell viability, migration and invasion, apoptosis, and miR-99a expression in MKN-45 and SGC-7901 cells were measured using CCK-8, Transwell assay, flow cytometry, and qPCR assays, respectively...
August 16, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156608/retraction-notice-for-comparison-of-arndt-endobronchial-blocker-plus-laryngeal-mask-airway-with-left-sided-double-lumen-endobronchial-tube-in-one-lung-ventilation-in-thoracic-surgery-in-the-morbidly-obese-braz-j-med-biol-res-2018-51-2-e6825
#6
(no author information available yet)
[This retracts the article doi: 10.1590/1414-431X20176825].
August 16, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30088541/saquinavir-plus-methylprednisolone-ameliorates-experimental-acute-lung-injury
#7
Guanghua Zhang, Xue Zhang, Haidi Huang, Yunxia Ji, Defang Li, Wanglin Jiang
Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity have not been previously investigated. In this study, the effects of SQV on lipopolysaccharide (LPS)-mediated injury in human pulmonary microvascular endothelial cells (HPMECs), human type I alveolar epithelial cells (AT I), and alveolar macrophages were determined...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30088540/adrenergic-receptor-%C3%AE-3-is-involved-in-the-memory-consolidation-process-in-mice
#8
P Souza-Braga, F B Lorena, B P P Nascimento, C P Marcelino, T T Ravache, E Ricci, M M Bernardi, M O Ribeiro
Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30088539/baicalein-alleviates-tubular-interstitial-nephritis-in-vivo-and-in-vitro-by-down-regulating-nf-%C3%AE%C2%BAb-and-mapk-pathways
#9
Yan Chen, Yu Zheng, Zhihong Zhou, Jinjun Wang
Tubular-interstitial nephritis (TIN) is characterized by tubular cell damage and inflammatory lesions of kidneys. Baicalein (BAI) is a flavonoid compound found in the roots of Scutellaria baicalensis Georgi. The present study was undertaken to explore the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide (LPS)-induced TIN cell model. The expression levels of interleukin-6 (IL-6), IL-10, and tumor necrosis factor α in serum samples of TIN patients and culture supernatants of renal proximal tubular epithelial cells (RPTECs) were evaluated using enzyme-linked immunosorbent assay...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30088538/icariin-reduces-human-colon-carcinoma-cell-growth-and-metastasis-by-enhancing-p53-activities
#10
Meili Tian, Shuang Yang, Xinpeng Yan
Icariin has been reported to possess high anticancer activity. Colon carcinoma is one of the leading causes of cancer-related mortality worldwide. Here, the anticancer activity of icariin against HCT116 colon carcinoma cells and the possible underlying mechanism were studied. The trypan blue staining assay, wound healing assay, clonogenic assay, CCK-8 assay, and Annexin V-FITC/PI double staining method were carried out to determine the changes of HCT116 cell growth and migration. mRNA and protein expressions were determined by quantitative real-time PCR and western blot, respectively...
August 6, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30066723/comparison-of-endoplasmic-reticulum-stress-and-mitochondrial-biogenesis-responses-after-12-weeks-of-treadmill-running-and-ladder-climbing-exercises-in-the-cardiac-muscle-of-middle-aged-obese-rats
#11
COMPARATIVE STUDY
Kijin Kim, Nayoung Ahn, Suryun Jung
The purpose of the present study was to compare the influence of aerobic exercise (AE) lasting 12 weeks to that of resistance exercise (RE) of the same duration on endoplasmic reticulum (ER) stress and mitochondrial biogenesis in the cardiac muscle of middle-aged obese rats. Obesity was induced in thirty 50-week-old male Sprague Dawley rats over 6 weeks by administration of a high-fat diet. The rats were then subjected to treadmill-running (AE) and ladder-climbing (RE) exercises 3 times per week for 12 weeks...
July 30, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30066722/omphaloceles-in-combination-with-a-self-made-hemispherical-cushion-a-report-of-12-cases
#12
Guoxian Huang, Lili Ma, Yonglong Wu
The aim of this study was to discuss the curative effect of applying "capsule-reserved normal saline bag and self-made hemi-spherical cushion oppression" for treating giant omphaloceles. Twelve patients with giant omphaloceles who were admitted to our hospital between January 2008 and June 2016 were selected for treatment as follows: a capsule-reserved normal saline bag was used to promote the gradual return of the abdominal contents into the abdominal cavity in phase I, and a self-made hemi-spherical cushion was used for compression combined with a local dressing change in phase II to treat the giant omphaloceles without surgical treatment...
July 30, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30066721/transplantation-of-rat-derived-microglial-cells-promotes-functional-recovery-in-a-rat-model-of-spinal-cord-injury
#13
COMPARATIVE STUDY
Dewei Kou, Tianmi Li, Hong Liu, Chuansheng Liu, Yanwei Yin, Xing Wu, Tengbo Yu
This study evaluated the effect of microglia transplantation on neurological functional recovery in rats subjected to traumatic spinal cord injury (SCI). The rat model of SCI was established using a weight drop device. Forty SCI rats were randomly divided into the microglia group and the saline group. Then, rat-derived microglial cells or normal saline was injected into the injured site 7 days after surgery. The Basso-Beattie-Bresnahan (BBB) score, inclined plate test, and motor-evoked potentials (MEPs) were applied to assess the recovery of motor function...
July 30, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30066727/intestinal-cell-migration-damage-induced-by-enteropathogenic-escherichia-coli-strains
#14
COMPARATIVE STUDY
P A Cavalcante, M M G Prata, P H Q S Medeiros, A V Alves da Silva, J S Quetz, M A V Reyes, T S Rodrigues, A K S Santos, S A Ribeiro, H N Veras, M D Bona, M S M G Amaral, F A P Rodrigues, I F N Lima, A Havt, A A M Lima
Epithelial cell migration is an essential response to enteric pathogens such as enteropathogenic Escherichia coli (EPEC). This study aimed to investigate the effects of EPEC infection on intestinal epithelial cell migration in vitro, as well as the involvement of type III secretion system (T3SS) and Rho GTPases. Crypt intestinal epithelial cells (IEC-6) were infected with EPEC strains (E2348/69, ΔescF, and the LDI001 strain isolated from a malnourished Brazilian child) and commensal E. coli HS. Wound migration and cell death assays were performed at different time-points...
July 26, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30066726/transcriptomic-differential-lncrna-expression-is-involved-in-neuropathic-pain-in-rat-dorsal-root-ganglion-after-spared-sciatic-nerve-injury
#15
P Mao, C R Li, S Z Zhang, Y Zhang, B T Liu, B F Fan
Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by high-throughput Illumina HiSeq2500 sequencing to profile the differential genes in L4-L6 DRGs following rat sciatic nerve tying. A total of 1,228 genes were up-regulated and 1,415 down-regulated. By comparing to rat lncRNA database, 86 known and 26 novel lncRNA genes were found to be differential...
July 26, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30043858/decreased-expression-of-chromodomain-helicase-dna-binding-protein-9-is-a-novel-independent-prognostic-biomarker-for-colorectal-cancer
#16
Li Xu, Hui Peng, Xiao-Xu Huang, Ya-Bin Xia, Kai-Feng Hu, Zheng-Ming Zhang
Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1-8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In this study, we assessed the prognostic value of CHD 9 in patients with colorectal cancer (CRC). We screened for CHD 9 expression using immunohistochemical analysis in 87 surgical CRC specimens and found that the expression was upregulated in 81...
July 23, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30043857/mechanistic-effect-of-the-human-gjb6-gene-and-its-mutations-in-hacat-cell-proliferation-and-apoptosis
#17
Yuting Lu, Ruili Zhang, Zhenying Wang, Shuhua Zhou, Yali Song, Lamei Chen, Nan Chen, Wenmin Liu, Canan Ji, Wangli Wu, Li Zhang
We constructed lentiviral vectors containing the human wild-type GJB6 gene and the mutant variants A88V and G11R. The three proteins were stably expressed by the Tet-on system in the HaCaT cell line and used to study the functional effect of the variants. The CCK-8 assay and flow cytometric analyses were used to determine the levels of cell proliferation and apoptosis. Western blot analyses were performed to analyze the relevant clinical indicators of hidrotic ectodermal dysplasia and markers of apoptosis in transfected HaCaT cells...
July 23, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30043856/decreased-muscle-strength-is-associated-with-proinflammatory-cytokines-but-not-testosterone-levels-in-men-with-diabetes
#18
J P Ferreira, A M O Leal, F A Vasilceac, C D Sartor, I C N Sacco, A S Soares, T F Salvini
The aim of this study was to compare muscle strength in male subjects with type 2 diabetes mellitus (DM2) with and without low plasma testosterone levels and assess the relationship between muscle strength, testosterone levels, and proinflammatory cytokines. Males (75) aged between 18 and 65 years were divided into 3 groups: control group that did not have diabetes and had a normal testosterone plasma level (>250 ng/dL), DnormalTT group that had DM2 with normal testosterone levels, and the DlowTT group that had DM2 and low plasma testosterone levels (<250 ng/dL)...
July 23, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30043855/plasma-lipid-abnormalities-in-pakistani-population-trends-associated-factors-and-clinical-implications
#19
M Zaid, S Hasnain
Previous studies have reported increased prevalence of coronary heart disease (CHD) in Indians and South Asian settlers in North America. This increased burden of CHD among South Asians is mainly caused by dyslipidemia. To the best of our knowledge, none of the previous works has studied the patterns and prevalence of dyslipidemia in the Pakistani population. The present work aimed to study the plasma lipid trends and abnormalities in a population-based sample of urban and rural Pakistanis. The study included 238 participants (108 males,130 females)...
July 23, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30043854/up-regulated-expression-of-cd147-gene-in-malignant-bone-tumor-and-the-possible-induction-mechanism-during-osteoclast-formation
#20
Suchi Qiao, Chang Liu, Weijie Xu, WuBuLi AZhaTi, Cheng Li, Zhiwei Wang
It is increasingly evident that the microenvironment of bone can influence cancer phenotype in many ways that favor growth in bone. CD147, a transmembrane protein of the immunoglobulin (Ig) superfamily, was identified independently in different species and has many designations across different species. However, expression levels of CD147 mRNA in bone cancer have not been described. In this study, we have used real-time fluorescence quantification (RT-PCR) to demonstrate CD147 expression in malignant bone cancer and benign bone tumor tissues...
July 23, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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