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Journals Brazilian Journal of Medical a...

Brazilian Journal of Medical and Biological Research

https://read.qxmd.com/read/38511770/silencing-of-matrix-metalloprotease-12-delays-the-progression-of-castration-resistant-prostate-cancer-by-regulating-autophagy-and-lipolysis
#1
JOURNAL ARTICLE
Xiaoyu Zheng, Xiaoqin Xie, Wei Wang, Liang Wang, Bing Tan
The complex pathogenesis of castration-resistant prostate cancer (CRPC) makes it challenging to identify effective treatment methods. Matrix metalloproteinase (MMP)-12 can degrade elastin as well as various extracellular matrix (ECM) components, which is associated with cancer progression. However, the relationship between MMP-12 and CRPC progression is poorly understood. In this study, we observed the effect of MMP-12 on the progression of CRPC and further explored its potential mechanism of action. High levels of MMP-12 were observed in patients with CRPC...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511769/upregulation-of-pgc-1%C3%AE-expression-by-pioglitazone-mediates-prevention-of-sepsis-induced-acute-lung-injury
#2
JOURNAL ARTICLE
Jing Tang, Wenzhu Dong, Dan Wang, Qin Deng, Honggang Guo, Guibao Xiao
The imbalance between pro-inflammatory M1 and anti-inflammatory M2 macrophages plays a critical role in the pathogenesis of sepsis-induced acute lung injury (ALI). Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may modulate macrophage polarization toward the M2 phenotype by altering mitochondrial activity. This study aimed to investigate the role of the PGC-1α agonist pioglitazone (PGZ) in modulating sepsis-induced ALI. A mouse model of sepsis-induced ALI was established using cecal ligation and puncture (CLP)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511768/serum-autophagy-related-gene-5-level-in-stroke-patients-correlation-with-cd4-t-cells-and-cognition-impairment-during-a-3-year-follow-up
#3
JOURNAL ARTICLE
Juanjuan Qu, Linxia Wu, Meng Zhang, Minchen Kan, Huimin Chen, Yanqing Shi, Shuangyu Wang, Xiaohua Wang, Fan Chen
Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4+ T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511767/temporal-evolution-of-postsurgical-bone-repair-in-a-rabbit-model-a-99mtc-tc-mdp-scintigraphic-study
#4
JOURNAL ARTICLE
A Yoneda, K J C C de Lacerda, L Alexandre-Santos, E N Itikawa, P Louzada-Junior, L Wichert-Ana
Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38511766/periodontitis-and-osteoporosis-a-two-sample-mendelian-randomization-analysis
#5
JOURNAL ARTICLE
Jiale Wu, Lihui Yao, Yuchen Liu, ShuaiShuai Zhang, Kan Wang
The incidences of periodontitis and osteoporosis are rising worldwide. Observational studies have shown that periodontitis is associated with increased risk of osteoporosis. We performed a Mendelian randomization (MR) study to genetically investigate the causality of periodontitis on osteoporosis. We explored the causal effect of periodontitis on osteoporosis by MR analysis. A total of 9 single nucleotide polymorphisms (SNP) were related to periodontitis. The primary approach in this MR analysis was the inverse variance-weighted (IVW) method...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38451609/phospholipase-d-regulates-ferroptosis-signal-transduction-in-mouse-spleen-hypoxia-response
#6
JOURNAL ARTICLE
Jiayang Wang, Ying Hu, Yuzhen Xu, Qifu Long, Cunlin Gu, Chaoqun Tang, Ru Wang, Sheng Yong
High-altitude hypoxia exposure can lead to phospholipase D-mediated lipid metabolism disorder in spleen tissues and induce ferroptosis. Nonetheless, the key genes underlying hypoxia-induced splenic phospholipase D and the ferroptosis pathway remain unclear. This study aimed to establish a hypoxia animal model. Combined transcriptomic and proteomic analyses showed that 95 predicted target genes (proteins) were significantly differentially expressed under hypoxic conditions. Key genes in phospholipase D and ferroptosis pathways under hypoxic exposure were identified by combining Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis techniques...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38451608/association-among-cardiopulmonary-and-metabolic-rehabilitation-arrhythmias-and-myocardial-ischemia-responses-of-patients-with-hfpef-or-hfmref
#7
JOURNAL ARTICLE
C A C Hossri, F C Araujo, B G Baldi, R Otterstetter, V R Uemoto, C R R Carvalho, L E Mastrocola, A L P Albuquerque
There's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical and mental health summary scores...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38451607/wearable-near-infrared-spectroscopy-reliability-and-sensitivity-among-different-endurance-cycling-exercise-intensities
#8
JOURNAL ARTICLE
J S Hasegawa, R A Azevedo, A C Silveira, A E Lima-Silva, R Bertuzzi
The present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇O2) were measured continuously...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38451606/stimulation-of-mouse-hematopoietic-stem-cells-by-angiogenin-and-dna-preparations
#9
JOURNAL ARTICLE
E A Potter, E V Dolgova, A S Proskurina, V S Ruzanova, Y R Efremov, S S Kirikovich, S G Oshikhmina, A L Mamaev, O S Taranov, A S Bryukhovetskiy, L U Grivtsova, N A Kolchanov, A A Ostanin, E R Chernykh, S S Bogachev
Immature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angiogenin on both hematopoietic stem cells and multipotent progenitors...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38381885/puerarin-protects-the-fatty-liver-from-ischemia-reperfusion-injury-by-regulating-the-pi3k-akt-signaling-pathway
#10
JOURNAL ARTICLE
Faji Yang, Hengjun Gao, Zheyu Niu, Qingqiang Ni, Huaqiang Zhu, Jianlu Wang, Jun Lu
The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high-fat diet (HFD) followed by ischemia reperfusion injury...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38381884/correlation-analysis-between-peripheral-blood-dendritic-cell-subsets-and-pd-1-in-patients-with-peritoneal-adenocarcinoma
#11
JOURNAL ARTICLE
Huihui Hu, Man Zhang
The aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grade and lymph node metastasis)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38381883/inhibition-of-anlotinib-induced-autophagy-attenuates-invasion-and-migration-by-regulating-epithelial-mesenchymal-transition-and-cytoskeletal-rearrangement-through-atg5-in-human-osteosarcoma-cells
#12
JOURNAL ARTICLE
Bingxin Zheng, Xiangchen Sun, Li Zhang, Guojian Qu, Chongmin Ren, Peng Yan, Chuanli Zhou, Bin Yue
The cure rates for osteosarcoma have remained unchanged in the past three decades, especially for patients with pulmonary metastasis. Thus, a new and effective treatment for metastatic osteosarcoma is urgently needed. Anlotinib has been reported to have antitumor effects on advanced osteosarcoma. However, both the effect of anlotinib on autophagy in osteosarcoma and the mechanism of anlotinib-mediated autophagy in pulmonary metastasis are unclear. The effect of anlotinib treatment on the metastasis of osteosarcoma was investigated by transwell assays, wound healing assays, and animal experiments...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38381882/diabetes-hemoglobin-a1c-and-cognitive-performance-in-older-adults-is-there-any-impact-of-frailty-evidence-from-the-elsi-brazil-study
#13
JOURNAL ARTICLE
J G Souza, D S Farias-Itao, M J R Aliberti, T S Alexandre, C Szlejf, C P Ferri, M F Lima-Costa, C K Suemoto
The aim of this study was to evaluate the association between diabetes and cognitive performance in a nationally representative study in Brazil. We also aimed to investigate the interaction between frailty and diabetes on cognitive performance. A cross-sectional analysis of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) baseline data that included adults aged 50 years and older was conducted. Linear regression models were used to study the association between diabetes and cognitive performance. A total of 8,149 participants were included, and a subgroup analysis was performed in 1,768 with hemoglobin A1c data...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38381881/effect-of-mch1-a-fatty-acid-amide-hydrolase-inhibitor-on-the-depressive-like-behavior-and-gene-expression-of-endocannabinoid-and-dopaminergic-signaling-system-in-the-mouse-nucleus-accumbens
#14
JOURNAL ARTICLE
C Medina-Saldivar, G V E Pardo, L F Pacheco-Otalora
MCH1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (FAAH), an enzyme responsible for endocannabinoid metabolism. This inhibition can modulate endocannabinoid and dopamine signaling in the nucleus accumbens (NAc), potentially having an antidepressant-like effect. The present study aimed to evaluate the effect of the in vivo administration of MCH1 (3, 10, and 30 mg/kg, ip) in 2-month-old BALB/c male mice (n=97) on forced swimming test (FST), light-dark box (LDB), and open field test (OFT) and on early gene expression changes 2 h after drug injection related to the endocannabinoid system (Cnr1 and Faah) and dopaminergic signaling (Drd1 and Drd2) in the NAc core...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38359273/safety-of-a-90-min-duration-of-intravenous-infusion-of-obinutuzumab-in-patients-with-b-cell-non-hodgkin-s-lymphoma-in-a-tertiary-hospital-in-china-a-prospective-open-label-exploratory-clinical-trial
#15
JOURNAL ARTICLE
Shuangshuang Xing, Yiqin Pu, Xiaoqian Zhao, Yan Hu, Feiyan Zhang, Zejuan Gu, Wei Xu, Lei Fan, Yi Miao, Jianyong Li
This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38359272/-penumbra-sign-in-knee-pain-a-case-of-distal-femur-osteomyelitis
#16
Hakan Koray Tosyali, Adem Çakir
"Penumbra sign" is a characteristic finding in magnetic resonance imaging (MRI) of Brodie's abscess, a rare variant of subacute osteomyelitis. We aimed to discuss the imaging finding penumbra sign that will help in the diagnosis of osteomyelitis and may be useful to clinicians in differential diagnosis. A 26-year-old male patient presented to the emergency department with complaints of pain and limping in the right knee that did not go away. He had a history of arthroscopic debridement and percutaneous fixation surgery due to osteochondral fragment 3 years ago...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38359271/factors-associated-with-non-treatment-of-hypertension-and-gender-differences-at-baseline-in-the-elsa-brasil-cohort
#17
JOURNAL ARTICLE
A K M Néri, R M F Xavier, S M A Matos, M C C Almeida, R M Ladeira, A A Lopes, D O C Lino, A P P Lázaro, R V B M Cairutas, J H Silva Júnior, J M O Lima, M C Chaves, R P Silva, G B Silva Júnior
The treatment of arterial hypertension (AH) contributes to the reduction of morbidity and mortality. Gender differences are likely to play a role, as non-treatment is associated with clinical and sociodemographic aspects. The aim of this study was to investigate the factors associated with non-treatment of AH and gender differences in hypertensive individuals from the ELSA-Brasil cohort. The study was conducted with 5,743 baseline hypertensive cohort participants. AH was considered if there was a previous diagnosis or if systolic blood pressure (SBP) was ≥140 and/or diastolic BP (DBP) was ≥90 mmHg...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38359270/protective-effect-of-sterubin-against-neurochemical-and-behavioral-impairments-in-rotenone-induced-parkinson-s-disease
#18
JOURNAL ARTICLE
M M Alqurashi, F A Al-Abbasi, M Afzal, A M Alghamdi, M Zeyadi, R A Sheikh, S Alshehri, S S Imam, N Sayyed, I Kazmi
This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38265347/assessing-the-reaction-to-and-efficacy-of-the-screener-drug-discovery-and-development-board-game-as-a-pedagogical-tool-in-postgraduate-courses
#19
JOURNAL ARTICLE
F Noël, G Xexéo, M A Martins, E J R Silva, A S Pupo, P J C Magalhães, R C P Lima-Júnior, K K L Gadelha, K Lima-Silva, J M Raimundo, P C Ghedini, M E Crespo-Lopez, G P Arrifano, J Ferreira, R D Prediger, G C G Militão, R B Oliveira, A W Hollais, L C M Rodrigues, D T Carvalho, S K P Costa, D T O Martins
Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology and Experimental Therapeutics to postgraduate programs as an instructional tool for the process of drug discovery and development (DDD). In this study, we provided a comprehensive analysis of five critical aspects for evaluating the quality of educational games, namely: 1) description of the intervention; 2) underlying pedagogical theory; 3) identification of local educational gaps; 4) impact on diverse stakeholders; and 5) elucidation of iterative quality enhancement processes...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38265346/didymin-protects-against-polystyrene-nanoplastic-induced-hepatic-damage-in-male-albino-rats-by-modulation-of-nrf-2-keap-1-pathway
#20
JOURNAL ARTICLE
M U Ijaz, N Nadeem, A Hamza, M H Almutairi, U Atique
Polystyrene nanoplastics (PS-NPs) are ubiquitous environmental pollutants that can cause oxidative stress in various organs, including the liver. Didymin is a dietary flavanone that displays multiple pharmacological activities. Therefore, the present study evaluated the palliative role of didymin against PS-NPs-induced hepatic damage in rats. Albino rats (n=48) were randomly distributed into 4 groups: control, PS-NPs treated group, PS-NPs + didymin co-administered group, and didymin supplemented group. After 30 days, PS-NPs intoxication lowered the expression of Nrf-2 and anti-oxidant genes [catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GSR), glutathione-S-transferase (GST), and heme oxygenase-1 (HO-1)], whereas the expression of KEAP1 kelch like ECH associated protein 1 (Keap-1) was increased...
2024: Brazilian Journal of Medical and Biological Research
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