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Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas

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https://www.readbyqxmd.com/read/30403260/the-rs878081-polymorphism-of-aire-gene-increases-the-risk-of-rheumatoid-arthritis-in-a-chinese-han-population-a-case-control-study
#1
Haoyu Yang, Jin Li, Lifeng Jiang, Xijia Jiang, Xindie Zhou, Nanwei Xu
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China...
November 1, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30403259/circular-rna-hsa_circ_0000523-regulates-the-proliferation-and-apoptosis-of-colorectal-cancer-cells-as-mirna-sponge
#2
Y Jin, L L Yu, B Zhang, C F Liu, Y Chen
Among the novel class of endogenous long non-coding RNAs, circular RNA (circRNA) is known as a key regulator in the development and progression of different cancers. Its function and mechanism in the tumorigenesis of colorectal cancer, however, has not been well studied. This study thus aimed to investigate potential regulation of colorectal cancer by circRNAs and the corresponding regulatory mechanism. We demonstrated that the expression of circRNA hsa_circ_0000523 (also known as circ_006229) was down-regulated in different colorectal cancer cell lines...
November 1, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30365726/low-intensity-pulsed-ultrasound-promotes-proliferation-and-migration-of-hacat-keratinocytes-through-the-pi3k-akt-and-jnk-pathways
#3
Xiaoyan Leng, Jing Shang, Danhui Gao, Jiang Wu
Although the effects of low-intensity pulsed ultrasound (LIPUS) on diverse cell types have been fully studied, the functional role of LIPUS in keratinocytes remains poorly understood. This study aimed to investigate the effects of LIPUS on proliferation and migration of HaCaT cells as well as the regulatory mechanisms associated with signaling pathways. Human HaCaT cells were exposed or not to LIPUS, and cell proliferation and migration were measured by BrdU incorporation assay and Transwell assay, respectively...
October 18, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30365725/microrna-221-promotes-cell-proliferation-migration-and-differentiation-by-regulation-of-zfpm2-in-osteoblasts
#4
Xingguo Zheng, Jinhua Dai, Haijun Zhang, Zhibin Ge
Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. The expression levels of miR-221 in the different groups were measured by qRT-PCR. Then, miR-221 mimic and inhibitor were transfected into MC3T3-E1 cells, and cell viability and migration were measured using the CCK-8 assay and the Transwell migration assay...
October 18, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30365724/cat-ownership-is-associated-with-increased-asthma-prevalence-and-dog-ownership-with-decreased-spirometry-values
#5
C S Simoneti, E Ferraz, M B Menezes, T R Icuma, E O Vianna
The association between pet ownership and the development of allergic and respiratory diseases has been the aim of several studies, however, the effects of exposure in adults remain uncertain. The aims of the present study were to investigate the prevalence of asthma and lung function status among dog and cat owners. This cross-sectional study was performed at two universities with students and workers who were allocated into 3 groups according to pet ownership in the previous year: cat owners, dog owners, and no pets (control group)...
October 18, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30365723/insights-on-the-epigenetic-mechanisms-underlying-pulmonary-arterial-hypertension
#6
R C P Luna, Y de Oliveira, J V C Lisboa, T R Chaves, T A M de Araújo, E E de Sousa, M Miranda Neto, L Pirola, V A Braga, J L de Brito Alves
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition...
October 18, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30328936/cardiorespiratory-and-metabolic-determinants-during-moderate-and-high-resistance-exercise-intensities-until-exhaustion-using-dynamic-leg-press-comparison-with-critical-load
#7
V M Arakelian, C L Goulart, R G Mendes, F C Caruso, V Baldissera, R Arena, A Borghi-Silva
The objective of this study was to assess cardiovascular, respiratory, and metabolic responses during a commonly used dynamic leg press resistance exercise until exhaustion (TEx) at different intensities and compare with critical load (CL). This was a prospective, cross-sectional, controlled, and crossover study. Twelve healthy young men (23±2.5 years old) participated. The subjects carried out three bouts of resistance exercise in different percentages of 1 repetition maximum (60, 75, and 90% 1RM) until TEx...
October 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30328935/laboratory-evidence-for-the-hematopoietic-potential-of-beta-vulgaris-leaf-and-stalk-extract-in-a-phenylhydrazine-model-of-anemia
#8
I Gheith, A El-Mahmoudy
This study was designed to provide laboratory evidence supporting the hematopoietic effect of Beta vulgaris (beet) leaf aqueous extract in phenylhydrazine-induced anemia model in albino rats. Extraction of the leaves/stalks was done by maceration in 30% hydro-ethanol for 48 h. An intraperitoneal injection of 20 mg/kg phenylhydrazine was applied for two consecutive days to develop hemolytic anemia on the 4th day after the 1st injection in 24 of 30 male albino rats. The animals were divided into 5 groups and received the following treatments: standard (ferrous ascorbate + folic acid; 13...
October 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30328934/propofol-attenuates-sepsis-induced-acute-kidney-injury-by-regulating-mir-290-5p-ccl-2-signaling-pathway
#9
Guodong Zheng, Hong Qu, Fen Li, Weiquan Ma, Hong Yang
Previous studies have indicated that propofol has immunomodulatory and antioxidative properties. However, the renoprotection effect and the precise mechanisms of propofol in sepsis-induced renal injury remain unclear. The purpose of the present study was to investigate the role of miR-290-5p/CCL-2 signaling in septic mice treatment with propofol. Mice were treated with propofol (50 mg/kg) twice within 24 h. Survival outcome was monitored within 48 h. The mRNA and protein levels were assayed by qRT-PCR and western blotting, respectively...
October 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304096/a-pilot-study-on-the-identification-of-human-papillomavirus-genotypes-in-tongue-cancer-samples-from-a-single-institution-in-ecuador
#10
G M Delgado Ramos, T G Cotter, L Flor Ramos, V Torres Floril, G A Ramos Martinez, J C Ruiz-Cabezas
The relationship between human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma has been established. However, data from Ecuador is limited. The objective of this study was to characterize HPV infection in Ecuadorian patients with tongue cancer. Fifty-three patients with tongue cancer treated at the tertiary referral center Sociedad de Lucha Contra el Cancer (SOLCA), Guayaquil, between 2006 and 2011 were identified. Linear Array® HPV genotyping was used to identify the presence and types of HPV on formalin-fixed paraffin-embedded biopsy samples from these patients with tongue cancer...
October 8, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304095/importance-of-the-putative-furin-recognition-site-742rnrr745-for-antiangiogenic-sema3c-activity-in-vitro
#11
I Valiulyte, V Preitakaite, A Tamasauskas, A Kazlauskas
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling pathway. Sema3 proteins convey their regulatory signals by binding to neuropilins and plexins receptors, which are located on the effector cell. These processes are regulated by furin endoproteinases that cleave RXRR motifs within the Sema, plexin-semaphorins-integrin, and C-terminal basic domains of Sema3 protein...
October 8, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304094/ventilation-induced-changes-correlate-to-pulmonary-vascular-response-and-vegf-vegfr-1-2-and-enos-expression-in-the-rat-model-of-postnatal-hypoxia
#12
R L Figueira, F L Gonçalves, A R Prado, M C Ribeiro, K M Costa, O Castro E Silva, L Sbragia
Neonatal asphyxia occurs due to reduction in oxygen supply to vital organs in the newborn. Rapid restoration of oxygen to the lungs after a long period of asphyxia can cause lung injury and decline of respiratory function, which result from the activity of molecules that induce vascular changes in the lung such as nitric oxide (NO) and vascular endothelial growth factors (VEGF). In this study, we evaluated the pulmonary and vascular morphometry of rats submitted to the model of neonatal asphyxia and mechanical ventilation, their expression of pulmonary VEGF, VEGF receptors (VEGFR-1/VEGFR-2), and endothelial NO synthase (eNOS)...
October 8, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304134/cryotherapy-biochemical-alterations-involved-in-reduction-of-damage-induced-by-exhaustive-exercise
#13
A B V Furtado, D D Hartmann, R P Martins, P C Rosa, I K da Silva, B S L Duarte, L U Signori, F A A Soares, G O Puntel
When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304133/lactate-upregulation-of-lactate-oxidation-complex-related-genes-is-blunted-in-left-ventricle-of-myocardial-infarcted-rats
#14
D Gabriel-Costa, T F Cunha, N A Paixão, R S Fortunato, I C C Rego-Monteiro, M L M Barreto-Chaves, P C Brum
Lactate modulates the expression of lactate oxidation complex (LOC)-related genes and cardiac blood flow under physiological conditions, but its modulatory role remains to be elucidated regarding pathological cardiac stress. The present study evaluated the effect of lactate on LOC-related genes expression and hemodynamics of hearts submitted to myocardial infarction (MI). Four weeks after MI or sham operation, isolated hearts of male Wistar rats were perfused for 60 min with Na+-lactate (20 mM). As expected, MI reduced cardiac contractility and relaxation with no changes in perfusion...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304132/latent-class-analysis-of-attention-and-white-matter-correlation-in-children-with-attention-deficit-hyperactivity-disorder
#15
A S U Rossi, L M Moura, M C Miranda, M Muszkat, C B Mello, O F A Bueno
This study aimed to explore attentional patterns among children with inattentive attention-deficit/hyperactivity disorder (ADHD-I) and children with typical development (TD), using a latent class analysis (LCA). Patterns of brain connectivity were also explored. The sample comprised 29 ADHD-I and 29 TD matched children. An LCA was conducted to reclassify subjects according to their attentional performance, considering cognitive measures of attention and behavioral symptoms, regardless of group of origin. The new clusters were then compared in respect to brain white matter measurements (extracted from diffusion tensor imaging)...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304131/acute-exercise-inhibits-gastric-emptying-of-liquids-in-rats-influence-of-the-no-cgmp-pathway
#16
A K M Cavalcante, R C L Siqueira, V N Feitosa Júnior, C R de Andrade, A A Santos, M T B Silva
We previously found that acute exercise inhibited the gastric emptying of liquid in awake rats by causing an acid-base imbalance. In the present study, we investigated the involvement of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, vasoactive intestinal peptide (VIP), and corticotropin-releasing factor (CRF) peptide in this phenomenon. Male rats were divided into exercise or sedentary group and were subjected to a 15-min swim session against a load (2.5 or 5% b.w.). The rate of gastric emptying was evaluated after 5, 10, or 20 min postprandially...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30304130/essential-oil-of-pterodon-polygalaeflorus-benth-attenuates-nociception-in-mice
#17
A N Coelho-de-Souza, C F Dos-Santos, L N Lopes-Filho, F R Holanda, A C Oliveira, Y A Gomes-Vasconcelos, K A Oliveira, F W Ferreira-da-Silva, K S Silva-Alves, J H Leal-Cardoso
Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon polygalaeflorus (EOPPgfl) and its acute toxic effects. The EEOPPgfl sample, which was extracted by steam distillation of the seeds, had a yield of 2...
October 4, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30183974/captopril-alleviates-hypertension-induced-renal-damage-inflammation-and-nf-%C3%AE%C2%BAb-activation
#18
Zhongyuan Gan, Dan Huang, Jiaye Jiang, Yuan Li, Hanqing Li, Yan Ke
Hypertensive renal damage generally occurs during the middle and late stages of hypertension, which is typically characterized by proteinuria and renal inflammation. Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been widely used for therapy of arterial hypertension and cardiovascular diseases. However, the protective effects of captopril on hypertension-induced organ damage remain elusive. The present study was designed to explore the renoprotective action of captopril in spontaneously hypertensive rats (SHR)...
September 3, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156596/relationship-between-heart-rate-variability-and-subclinical-thyroid-disorders-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#19
É J F Peixoto de Miranda, R A Hoshi, M S Bittencourt, A C Goulart, I S Santos, A R Brunoni, M F H S Diniz, A L P Ribeiro, E M Dantas, J G Mill, P A Lotufo, I M Benseñor
The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper and SCHypo were classified by use of medication to treat thyroid disorders, thyrotropin levels respectively above and under the reference range, and normal free thyroxine levels...
August 27, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/30156611/gastrodin-induced-ho-1-and-nrf2-up-regulation-to-alleviate-h2o2-induced-oxidative-stress-in-mouse-liver-sinusoidal-endothelial-cells-through-p38-mapk-phosphorylation
#20
Hongbin Zhang, Bo Yuan, Hanfei Huang, Siming Qu, Shikun Yang, Zhong Zeng
Nuclear factor erythroid-related factor 2 (Nrf2) has been implicated in several detoxifying and antioxidant defense processes. Nrf2-mediated heme oxygenase-1 (HO-1) expression was demonstrated to play a key role against oxidative stress. Gastrodin (GSTD) is a well-known active compound isolated from the roots of Rhizoma gastrodiae, a plant used in ancient Chinese traditional medicine. The aim of this work was to investigate whether GSTD could alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells (LSECs)...
August 16, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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