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Journal of Cerebral Blood Flow and Metabolism

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https://www.readbyqxmd.com/read/28446106/real-time-detection-of-lesion-development-in-acute-brain-injury
#1
Jed A Hartings, Jens P Dreier
No abstract text is available yet for this article.
May 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366136/poster-viewing-session-v
#2
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366135/poster-viewing-session-iii
#3
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366134/poster-viewing-session-ii
#4
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366133/the-niels-lassen-award-session-and-oral-sessions
#5
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366132/poster-viewing-session-vi
#6
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366131/poster-viewing-session-iv
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28366130/poster-viewing-session-i
#8
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28155572/exploring-the-role-of-microglia-in-cortical-spreading-depression-in-neurological-disease
#9
Mamoru Shibata, Norihiro Suzuki
Microglia play a pivotal role in innate immunity in the brain. During development, they mature from myeloerythroid progenitor cells in the yolk sac and colonize the brain to establish a resident population of tissue macrophages. In the postnatal brain, they exert phagocytosis and induce inflammatory response against invading pathogens. Microglia also act as guardians of brain homeostasis by surveying the microenvironment using motile processes. Cortical spreading depression (CSD) is a slowly propagating (2-5 mm/min) wave of rapid, near-complete depolarization of neurons and astrocytes followed by a period of electrical suppression of a distinct population of cortical neurons...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28139935/systemic-activation-of-toll-like-receptor-2-suppresses-mitochondrial-respiration-and-exacerbates-hypoxic-ischemic-injury-in-the-developing-brain
#10
Amin Mottahedin, Pernilla Svedin, Syam Nair, Carl-Johan Mohn, Xiaoyang Wang, Henrik Hagberg, Joakim Ek, Carina Mallard
Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma and Gram-positive bacteria, for which Toll-like receptor 2 (TLR2) plays a key role in recognition and inflammatory response, are among the most common pathogens in the perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss and demyelination induced by subsequent hypoxia-ischemia (HI) in neonatal mice. High-resolution respirometry of brain isolated mitochondria revealed that P3C suppresses ADP-induced oxidative phosphorylation, the main pathway of cellular energy production...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27401806/cerebral-blood-flow-mri-in-the-nondemented-elderly-is-not-predictive-of-post-operative-delirium-but-is-correlated-with-cognitive-performance
#11
Tammy T Hshieh, Weiying Dai, Michele Cavallari, Charles Rg Guttmann, Dominik S Meier, Eva M Schmitt, Bradford C Dickerson, Daniel Z Press, Edward R Marcantonio, Richard N Jones, Yun Ray Gou, Thomas G Travison, Tamara G Fong, Long Ngo, Sharon K Inouye, David C Alsop
Three-dimensional Arterial Spin Labeling (ASL) MRI was performed before surgery in a cohort of 146 prospectively enrolled subjects ≥ 70 years old scheduled to undergo elective surgery. We investigated the prospective association between ASL-derived measures of cerebral blood flow (CBF) before surgery with postoperative delirium incidence and severity using whole-brain and globally normalized voxel-wise analysis. We also investigated the cross-sectional association of CBF with patients' baseline performance on specific neuropsychological tests, and with a composite general cognitive performance measure (GCP)...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27401805/quantitative-hemodynamic-pet-imaging-using-image-derived-arterial-input-function-and-a-pet-mr-hybrid-scanner
#12
Yi Su, Andrei G Vlassenko, Lars E Couture, Tammie Ls Benzinger, Abraham Z Snyder, Colin P Derdeyn, Marcus E Raichle
Positron emission tomography (PET) with (15)O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative (15)O-PET imaging...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27389180/is-ultrasound-perfusion-imaging-capable-of-detecting-mismatch-a-proof-of-concept-study-in-acute-stroke-patients
#13
Raluca Reitmeir, Jens Eyding, Markus F Oertel, Roland Wiest, Jan Gralla, Urs Fischer, Pierre-Yves Giquel, Stefan Weber, Andreas Raabe, Heinrich P Mattle, Werner J Z'Graggen, Jürgen Beck
In this study, we compared contrast-enhanced ultrasound perfusion imaging with magnetic resonance perfusion-weighted imaging or perfusion computed tomography for detecting normo-, hypo-, and nonperfused brain areas in acute middle cerebral artery stroke. We performed high mechanical index contrast-enhanced ultrasound perfusion imaging in 30 patients. Time-to-peak intensity of 10 ischemic regions of interests was compared to four standardized nonischemic regions of interests of the same patient. A time-to-peak >3 s (ultrasound perfusion imaging) or >4 s (perfusion computed tomography and magnetic resonance perfusion) defined hypoperfusion...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27389176/reduced-global-brain-metabolism-but-maintained-vascular-function-in-amnestic-mild-cognitive-impairment
#14
Binu P Thomas, Min Sheng, Benjamin Y Tseng, Takashi Tarumi, Kristen Martin-Cook, Kyle B Womack, Munro C Cullum, Benjamin D Levine, Rong Zhang, Hanzhang Lu
Amnestic mild cognitive impairment represents an early stage of Alzheimer's disease, and characterization of physiological alterations in mild cognitive impairment is an important step toward accurate diagnosis and intervention of this condition. To investigate the extent of neurodegeneration in patients with mild cognitive impairment, whole-brain cerebral metabolic rate of oxygen in absolute units of µmol O2/min/100 g was quantified in 44 amnestic mild cognitive impairment and 28 elderly controls using a novel, non-invasive magnetic resonance imaging method...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27381827/autocrine-release-of-angiopoietin-2-mediates-cerebrovascular-disintegration-in-moyamoya-disease
#15
Kinga G Blecharz, Dietmar Frey, Tobias Schenkel, Vincent Prinz, Gloria Bedini, Susanne M Krug, Marcus Czabanka, Josephin Wagner, Michael Fromm, Anna Bersano, Peter Vajkoczy
Moyamoya disease is a rare steno-occlusive cerebrovascular disorder often resulting in hemorrhagic and ischemic strokes. Although sharing the same ischemic stimulus with atherosclerotic cerebrovascular disease, Moyamoya disease is characterized by a highly instable cerebrovascular system which is prone to rupture due to pathological neovascularization. To understand the molecular mechanisms underlying this instability, angiopoietin-2 gene expression was analyzed in middle cerebral artery lesions obtained from Moyamoya disease and atherosclerotic cerebrovascular disease patients...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27381825/sestrin2-as-a-negative-feedback-regulator-of-mtor-provides-neuroprotection-by-activation-ampk-phosphorylation-in-neonatal-hypoxic-ischemic-encephalopathy-in-rat-pups
#16
Xudan Shi, Liang Xu, Desislava Met Doycheva, Jiping Tang, Min Yan, John H Zhang
Hypoxic-ischemic encephalopathy is a condition caused by reduced oxygen and cerebral blood flow to the brain resulting in neurological impairments. Effective therapeutic treatments to ameliorate these disabilities are still lacking. We sought to investigate the role of sestrin2, a highly conserved stress-inducible protein, in a neonatal rat hypoxic-ischemic encephalopathy model. Ten-day-old rat pups underwent right common carotid artery ligation followed by 2.5 h hypoxia. At 1 h post hypoxic-ischemic encephalopathy, rats were intranasally administered with recombinant human sestrin2 and sacrificed for brain infarct area measurement, Fluoro-Jade C, immunofluorescence staining, Western blot, and neurological function testing...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27381824/quantitative-longitudinal-imaging-of-activated-microglia-as-a-marker-of-inflammation-in-the-pilocarpine-rat-model-of-epilepsy-using-11-c-r-pk11195-pet-and-mri
#17
J Yankam Njiwa, N Costes, C Bouillot, S Bouvard, S Fieux, G Becker, E Levigoureux, G Kocevar, C Stamile, J B Langlois, R Bolbos, C Bonnet, L Bezin, L Zimmer, A Hammers
Inflammation may play a role in the development of epilepsy after brain insults. [(11)C]-( R)-PK11195 binds to TSPO, expressed by activated microglia. We quantified [(11)C]-( R)-PK11195 binding during epileptogenesis after pilocarpine-induced status epilepticus (SE), a model of temporal lobe epilepsy. Nine male rats were studied thrice (D0-1, D0 + 6, D0 + 35, D0 = SE induction). In the same session, 7T T2-weighted images and DTI for mean diffusivity (MD) and fractional anisotropy (FA) maps were acquired, followed by dynamic PET/CT...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27381823/embryonic-lethal-abnormal-vision-proteins-and-adenine-and-uridine-rich-element-mrnas-after-global-cerebral-ischemia-and-reperfusion-in-the-rat
#18
Haihui Wang, Fika Tri Anggraini, Xuequn Chen, Donald J DeGracia
Prolonged translation arrest correlates with delayed neuronal death of hippocampal CA1 neurons following global cerebral ischemia and reperfusion. Many previous studies investigated ribosome molecular biology, but mRNA regulatory mechanisms after brain ischemia have been less studied. Here we investigated the embryonic lethal abnormal vision/Hu isoforms HuR, HuB, HuC, and HuD, as well as expression of mRNAs containing adenine and rich uridine elements following global ischemia in rat brain. Proteomics of embryonic lethal abnormal vision immunoprecipitations or polysomes isolated from rat hippocampal CA1 and CA3 from controls or following 10 min ischemia plus 8 h of reperfusion showed distinct sets of mRNA-binding proteins, suggesting differential mRNA regulation in each condition...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27364001/four-dimensional-flow-magnetic-resonance-imaging-and-ultrasound-assessment-of-cerebrospinal-venous-flow-in-multiple-sclerosis-patients-and-controls
#19
Eric M Schrauben, Sarah Kohn, Jacob Macdonald, Kevin M Johnson, Mark Kliewer, Sam Frost, John O Fleming, Oliver Wieben, Aaron Field
A possibly causal relationship between multiple sclerosis and chronic cerebrospinal venous insufficiency has recently been hypothesized. Studies investigating chronic cerebrospinal venous insufficiency have reported conflicting results and few have employed multiple diagnostic imaging modalities across a large patient and control population. In this study, three complementary imaging modalities were used to investigate the chronic cerebrospinal venous insufficiency hypothesis in patients with multiple sclerosis and two age- and sex-matched control groups: healthy volunteers and patients with other neurological diseases...
April 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27354094/amylin-alters-human-brain-pericyte-viability-and-ng2-expression
#20
Nina Schultz, Elin Byman, Malin Fex, Malin Wennström
Amylin, a pancreatic β-cell-derived peptide hormone, forms inclusions in brain microvessels of patients with dementia who have been diagnosed with type 2 diabetes and Alzheimer's disease. The cellular localization of these inclusions and the consequences thereof are not yet known. Using immunohistochemical staining of hippocampus and parahippocampal cortex from patients with Alzheimer's disease and non-demented controls, we show that amylin cell inclusions are found in pericytes. The number of amylin cell inclusions did not differ between patients with Alzheimer's disease and controls, but amylin-containing pericytes displayed nuclear changes associated with cell death and reduced expression of the pericyte marker neuron-glial antigen 2...
April 2017: Journal of Cerebral Blood Flow and Metabolism
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