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Journal of Cerebral Blood Flow and Metabolism

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https://www.readbyqxmd.com/read/28965487/2018-the-beginning-of-a-new-era
#1
Jun Chen, Rick Dijkhuizen, Peter Herscovitch, Guohua Xi, Patrick Lyden
No abstract text is available yet for this article.
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28816095/new-astroglial-injury-defined-biomarkers-for-neurotrauma-assessment
#2
Julia Halford, Sean Shen, Kyohei Itamura, Jaclynn Levine, Albert C Chong, Gregg Czerwieniec, Thomas C Glenn, David A Hovda, Paul Vespa, Ross Bullock, W Dalton Dietrich, Stefania Mondello, Joseph A Loo, Ina-Beate Wanner
Traumatic brain injury (TBI) is an expanding public health epidemic with pathophysiology that is difficult to diagnose and thus treat. TBI biomarkers should assess patients across severities and reveal pathophysiology, but currently, their kinetics and specificity are unclear. No single ideal TBI biomarker exists. We identified new candidates from a TBI CSF proteome by selecting trauma-released, astrocyte-enriched proteins including aldolase C (ALDOC), its 38kD breakdown product (BDP), brain lipid binding protein (BLBP), astrocytic phosphoprotein (PEA15), glutamine synthetase (GS) and new 18-25kD-GFAP-BDPs...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28816088/new-biomarker-stars-for-traumatic-brain-injury
#3
Aleksandra Ichkova, Jerome Badaut
No abstract text is available yet for this article.
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28786737/corrigendum
#4
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28753105/the-vascular-basement-membrane-in-the-healthy-and-pathological-brain
#5
Maj S Thomsen, Lisa J Routhe, Torben Moos
The vascular basement membrane contributes to the integrity of the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive support from pericytes embedded in the vascular basement membrane and from astrocyte endfeet. The vascular basement membrane forms a three-dimensional protein network predominantly composed of laminin, collagen IV, nidogen, and heparan sulfate proteoglycans that mutually support interactions between BCECs, pericytes, and astrocytes. Major changes in the molecular composition of the vascular basement membrane are observed in acute and chronic neuropathological settings...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28752790/ph-imaging-reveals-worsened-tissue-acidification-in-diffusion-kurtosis-lesion-than-the-kurtosis-diffusion-lesion-mismatch-in-an-animal-model-of-acute-stroke
#6
Enfeng Wang, Yin Wu, Jerry S Cheung, Iris Yuwen Zhou, Takahiro Igarashi, XiaoAn Zhang, Phillip Zhe Sun
Diffusion weighted imaging (DWI) has been commonly used in acute stroke examination, yet a portion of DWI lesion may be salvageable. Recently, it has been shown that diffusion kurtosis imaging (DKI) defines the most severely damaged DWI lesion that does not renormalize following early reperfusion. We postulated that the diffusion and kurtosis lesion mismatch experience heterogeneous hemodynamic and/or metabolic injury. We investigated tissue perfusion, pH, diffusion, kurtosis and relaxation from regions of the contralateral normal area, diffusion lesion, kurtosis lesion and their mismatch in an animal model of acute stroke...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28752781/is-age-a-key-factor-contributing-to-the-disparity-between-success-of-neuroprotective-strategies-in-young-animals-and-limited-success-in-elderly-stroke-patients-focus-on-protein-homeostasis
#7
Wei Yang, Wulf Paschen
Neuroprotection strategies to improve stroke outcome have been successful in the laboratory but not in clinical stroke trials, and thus have come under scrutiny by the medical community. Experimental stroke investigators are therefore under increased pressure to resolve this problem. Acute ischemic stroke represents a severe form of metabolic stress that activates many pathological processes and thereby impairs cellular functions. Traditionally, neuroprotection strategies were designed to improve stroke outcome by interfering with pathological processes triggered by ischemia...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28393638/vascular-territorial-segmentation-and-volumetric-blood-flow-measurement-using-dynamic-contrast-enhanced-magnetic-resonance-angiography-of-the-brain
#8
Oren Geri, Shelly I Shiran, Jonathan Roth, Moran Artzi, Liat Ben-Sira, Dafna Ben Bashat
This study proposes a method for territorial segmentation and volumetric flow rate (VFR) distribution measurement of cerebral territories based on time-resolved contrast enhanced magnetic-resonance-angiography (MRA). The method uses an iterative region-growing algorithm based on bolus-arrival-time with increased temporal resolution. Eight territories were segmented: (1) right and (2) left internal carotid arteries, including the middle cerebral artery (ICA+MCA), excluding the anterior cerebral arteries (ACA); (3) right and left ACA (R+L-ACA); (4) right and (5) left external carotid arteries (ECA); (6) right and (7) left posterior cerebral arteries (PCA); and (8) vertebrobasilar territory...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28350253/3d-visualization-and-quantification-of-microvessels-in-the-whole-ischemic-mouse-brain-using-solvent-based-clearing-and-light-sheet-microscopy
#9
Erlen Lugo-Hernandez, Anthony Squire, Nina Hagemann, Alexandra Brenzel, Maryam Sardari, Jana Schlechter, Eduardo H Sanchez-Mendoza, Matthias Gunzer, Andreas Faissner, Dirk M Hermann
The visualization of cerebral microvessels is essential for understanding brain remodeling after stroke. Injection of dyes allows for the evaluation of perfused vessels, but has limitations related either to incomplete microvascular filling or leakage. In conventional histochemistry, the analysis of microvessels is limited to 2D structures, with apparent limitations regarding the interpretation of vascular circuits. Herein, we developed a straight-forward technique to visualize microvessels in the whole ischemic mouse brain, combining the injection of a fluorescent-labeled low viscosity hydrogel conjugate with 3D solvent clearing followed by automated light sheet microscopy...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28273724/imaging-angiogenesis-using-68-ga-nota-prgd2-positron-emission-tomography-computed-tomography-in-patients-with-severe-intracranial-atherosclerotic-disease
#10
Shi Shu, Li Zhang, Yi Cheng Zhu, Fang Li, Li Ying Cui, Hao Wang, Yi Sun, Pei Lin Wu, Zhao Hui Zhu, Bin Peng
Angiogenesis is a critical compensation route, which has been demonstrated in the brain following ischemic stroke; however, few studies have investigated angiogenesis in chronic intracranial atherosclerosis disease (ICAD). We used (68)Ga-NOTA-PRGD2 positron emission tomography/computed tomography based imaging to detect angiogenesis in chronic ICAD and to explore the factors that may have affected it. A total of 21 participants with unilateral severe chronic ICAD were included in the study. Of the 21 participants, 19 were men; the mean (SD) age was 52 (15) years...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28178896/sequential-pet-estimation-of-cerebral-oxygen-metabolism-with-spontaneous-respiration-of-15-o-gas-in-mice-with-bilateral-common-carotid-artery-stenosis
#11
Takashi Temma, Makoto Yamazaki, Jun Miyanohara, Hisashi Shirakawa, Naoya Kondo, Kazuhiro Koshino, Shuji Kaneko, Hidehiro Iida
Positron emission tomography with (15)O-labeled gases ((15)O-PET) is important for in vivo measurement of cerebral oxygen metabolism both in clinical and basic settings. However, there are currently no reports concerning (15)O-PET in mice. Here, we developed an (15)O-PET method applicable to mice with spontaneous respiration of (15)O-gas without a tracheotomy catheter. Sequential (15)O-PET was also performed in a mouse model of chronic cerebral hypoperfusion with bilateral common carotid artery stenosis (BCAS) induced by placement of microcoils...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28145796/identification-of-neurovascular-changes-associated-with-cerebral-amyloid-angiopathy-from-subject-specific-hemodynamic-response-functions
#12
Rebecca J Williams, Bradley G Goodyear, Stefano Peca, Cheryl R McCreary, Richard Frayne, Eric E Smith, G Bruce Pike
Cerebral amyloid angiopathy (CAA) is a small-vessel disease preferentially affecting posterior brain regions. Recent evidence has demonstrated the efficacy of functional MRI in detecting CAA-related neurovascular injury, however, it is unknown whether such perturbations are associated with changes in the hemodynamic response function (HRF). Here we estimated HRFs from two different brain regions from block design activation data, in light of recent findings demonstrating how block designs can accurately reflect HRF parameter estimates while maximizing signal detection...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28128026/amide-proton-transfer-weighted-mri-detection-of-traumatic-brain-injury-in-rats
#13
Hong Zhang, Wenzhu Wang, Shanshan Jiang, Yi Zhang, Hye-Young Heo, Xianlong Wang, Yun Peng, Jian Wang, Jinyuan Zhou
The purpose of this study was to explore the capability and uniqueness of amide proton transfer-weighted (APTw) imaging in the detection of primary and secondary injury after controlled cortical impact (CCI)-induced traumatic brain injury (TBI) in rats. Eleven adult rats had craniotomy plus CCI surgery under isoflurane anesthesia. Multi-parameter MRI data were acquired at 4.7 T, at eight time points (1, 6 h, and 1, 2, 3, 7, 14, and 28 days after TBI). At one and six hours post-injury, average APTw signal intensities decreased significantly in the impacted and peri-lesional areas due to tissue acidosis...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28112023/cerebral-collateral-therapeutics-in-acute-ischemic-stroke-a-randomized-preclinical-trial-of-four-modulation-strategies
#14
Simone Beretta, Alessandro Versace, Davide Carone, Matteo Riva, Valentina Dell'Era, Elisa Cuccione, Ruiyao Cai, Laura Monza, Silvia Pirovano, Giada Padovano, Fabio Stiro, Luca Presotto, Giovanni Paternò, Emanuela Rossi, Carlo Giussani, Erik P Sganzerla, Carlo Ferrarese
Cerebral collaterals are dynamically recruited after arterial occlusion and highly affect tissue outcome in acute ischemic stroke. We investigated the efficacy and safety of four pathophysiologically distinct strategies for acute modulation of collateral flow (collateral therapeutics) in the rat stroke model of transient middle cerebral artery (MCA) occlusion. A composed randomization design was used to assign rats (n = 118) to receive phenylephrine (induced hypertension), polygeline (intravascular volume load), acetazolamide (cerebral arteriolar vasodilation), head down tilt (HDT) 15° (cerebral blood flow diversion), or no treatment, starting 30 min after MCA occlusion...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28112022/structural-and-physiological-neurovascular-changes-in-idiopathic-parkinson-s-disease-and-its-clinical-phenotypes
#15
Sarah Al-Bachari, Rishma Vidyasagar, Hedley Ca Emsley, Laura M Parkes
Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson's disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements of cerebral blood flow (CBF) and arterial arrival time (AAT). We investigated NVS in IPD, including an analysis of IPD clinical phenotypes, by comparison with two control groups, one with a history of clinical cerebrovascular disease (CVD) (control positive, CP) and one without CVD (control negative, CN)...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28094605/multiple-protocadherins-are-expressed-in-brain-microvascular-endothelial-cells-and-might-play-a-role-in-tight-junction-protein-regulation
#16
Christina Dilling, Norbert Roewer, Carola Y Förster, Malgorzata Burek
Protocadherins (Pcdhs) are a large family of cadherin-related molecules. They play a role in cell adhesion, cellular interactions, and development of the central nervous system. However, their expression and role in endothelial cells has not yet been characterized. Here, we examined the expression of selected clustered Pcdhs in endothelial cells from several vascular beds. We analyzed human and mouse brain microvascular endothelial cell (BMEC) lines and primary cells, mouse myocardial microvascular endothelial cell line, and human umbilical vein endothelial cells...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28084873/hypothermia-revisited-impact-of-ischaemic-duration-and-between-experiment-variability
#17
Sarah Sj Rewell, Amy L Jeffreys, Steven A Sastra, Susan F Cox, John A Fernandez, Elena Aleksoska, H Bart van der Worp, Leonid Churilov, Malcolm R Macleod, David W Howells
To assess the true effect of novel therapies for ischaemic stroke, a positive control that can validate the experimental model and design is vital. Hypothermia may be a good candidate for such a positive control, given the convincing body of evidence from animal models of ischaemic stroke. Taking conditions under which substantial efficacy had been seen in a meta-analysis of hypothermia for focal ischaemia in animal models, we undertook three randomised and blinded studies examining the effect of hypothermia induced immediately following the onset of middle cerebral artery occlusion on infarct volume in rats (n = 15, 23, 264)...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28075691/complexity-of-brain-signals-is-associated-with-outcome-in-preterm-infants
#18
Cristine Sortica da Costa, Michal M Placek, Marek Czosnyka, Brenno Cabella, Magdalena Kasprowicz, Topun Austin, Peter Smielewski
A characteristic feature of complex healthy biological systems is the ability to react and adapt to minute changes in the environment. This 'complexity' manifests itself in highly irregular patterns of various physiological measurements. Here, we apply Multiscale Entropy (MSE) analysis to assess the complexity of systemic and cerebral near-infrared spectroscopy (NIRS) signals in a cohort of 61 critically ill preterm infants born at median (range) gestational age of 26 (23-31) weeks, before 24 h of life. We further correlate the complexity of these parameters with brain injury and mortality...
October 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28695754/controlled-arterial-reflow-after-ischemia-induces-better-outcomes-in-the-juvenile-rat-brain
#19
Philippe Bonnin, Julien Pansiot, Elise Paven, Maxime Eloi, Sylvain Renolleau, Olivier Baud, Pierre-Louis Leger, Christiane Charriaut-Marlangue
Our objective was to determine whether controlled reflow on one side and/or the other side after bilateral carotid occlusion release could reduce cell death in focal ischemic P14 rats. Arterial blood flow was measured using ultrasonography. Cell death, inflammation and nitrotyrosine were measured using immunofluorescence. When reflow was first induced in the contralateral side, we observed improved outcome markers compared with those when reflow was first induced in the ipsilateral side and/or simultaneous reflow was induced in both sides...
September 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28665172/treatment-with-low-dose-fasudil-for-acute-ischemic-stroke-in-chronic-hypertension
#20
Siu-Lung Chan, Marilyn J Cipolla
We investigated the effect of Rho kinase inhibition on changes in cerebral blood flow (CBF), brain injury and vascular function after ischemic stroke in spontaneously hypertensive rats (SHR). Changes in core MCA and collateral perfusion were measured by a validated laser Doppler method. Animals underwent 2 h tMCAO and 2 h reperfusion. Fasudil (0.1 mg/kg, i.v.) or vehicle was given at 30 min ischemia (n = 9/group; mean (SD)). Brain injury was determined by 2,3,5-triphenyltetrazolium chloride staining...
September 2017: Journal of Cerebral Blood Flow and Metabolism
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