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Breast Cancer Research and Treatment

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https://www.readbyqxmd.com/read/28110478/response-to-do-metastasis-free-interval-less-or-more-than-24-months-for-recurrent-metastatic-breast-cancer-and-primary-surgery-for-de-novo-metastatic-breast-cancer-matter-for-survival
#1
LETTER
Wendie D den Brok, Caroline H Speers, Lovedeep Gondara, Emily Baxter, Scott K Tyldesley, Caroline A Lohrisch
No abstract text is available yet for this article.
January 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28093659/clinical-and-molecular-relevance-of-mutant-allele-tumor-heterogeneity-in-breast-cancer
#2
Ding Ma, Yi-Zhou Jiang, Xi-Yu Liu, Yi-Rong Liu, Zhi-Ming Shao
PURPOSE: Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. METHODS: We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome sequencing data and further investigated their correlation with clinical characteristics, somatic mutations, somatic copy number alterations (SCNAs), and gene enrichment...
January 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28091861/do-metastasis-free-interval-less-or-more-than-24%C3%A2-months-for-recurrent-metastatic-breast-cancer-and-primary-surgery-for-de-novo-metastatic-breast-cancer-matter-for-survival
#3
LETTER
Kadri Altundag
No abstract text is available yet for this article.
January 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28091860/retesting-brca1-brca2-mutation-negative-male-breast-cancer-patients-using-next-generation-sequencing-technologies
#4
LETTER
Piera Rizzolo, Valentina Silvestri, Laura Ottini
No abstract text is available yet for this article.
January 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28084583/brain-metastasis-in-patients-with-metastatic-breast-cancer-in-the-real-world-a-single-institution-retrospective-review-of-12-year-follow-up
#5
Satomi Matsuo, Junichiro Watanabe, Koichi Mitsuya, Nakamasa Hayashi, Yoko Nakasu, Mitsuhiro Hayashi
PURPOSE: The data of 589 metastatic breast cancer (MBC) patients in a single institution were reviewed to determine the outcomes of patients with brain metastasis (BM) and assess the efficacy of BM screening. METHODS: The patients with BM among the 589 MBC patients who underwent treatment at Shizuoka Cancer Center (Shizuoka, Japan) from 09/2002 to 03/2014 were retrospectively analyzed. RESULTS: During the study period, BM developed in 187 (31...
January 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28083822/diagnostic-performance-of-tomosynthesis-and-breast-ultrasonography-in-women-with-dense-breasts-a-prospective-comparison-study
#6
Won Hwa Kim, Jung Min Chang, Joongyub Lee, A Jung Chu, Mirinae Seo, Hye Mi Gweon, Hye Ryoung Koo, Su Hyun Lee, Nariya Cho, Min Sun Bae, Sung Ui Shin, Sung Eun Song, Woo Kyung Moon
PURPOSE: To compare the diagnostic performances of tomosynthesis and ultrasonography as adjunctives to digital mammography in women with dense breasts. METHODS: A total of 778 women with dense breasts underwent digital mammography with tomosynthesis and ultrasonography for screening and diagnostic purposes. The findings of tomosynthesis and ultrasonography were evaluated independently. The primary endpoint was overall diagnostic accuracy determined by area under the receiver operating characteristic curve (AUC)...
January 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28083821/surgical-treatment-of-secondary-lymphedema-of-the-upper-limb-by-stepped-microsurgical-lymphaticovenous-anastomoses
#7
REVIEW
Marie-Anne Poumellec, Rémi Foissac, Marianne Cegarra-Escolano, Emmanuel Barranger, Tarik Ihrai
OBJECTIVE: The incidence of lymphedema following treatment for breast cancer ranges between 10 and 50% after complete axillary dissection and gives rise to severe functional discomfort in patients. Results of lymphaticovenous anastomoses (LVA) in surgical treatment of lymphedema appear to be favorable. However, the available literature on this topic is scarce, often with short follow-up times. The aim of this study is to analyze the results of LVA on 31 patients and to review the existing literature...
January 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28083820/recurrence-outcomes-after-omission-of-postoperative-radiotherapy-following-breast-conserving-surgery-for-ductal-carcinoma-in-situ-of-the-breast-a-multicenter-retrospective-study-in-korea-krog-16-02
#8
Kyubo Kim, So-Youn Jung, Kyung Hwan Shin, Jin Ho Kim, Wonshik Han, Han-Byoel Lee, Seung Jae Huh, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Jin Hee Kim, Chang-Ok Suh, Yong Bae Kim, In Ah Kim, Suzy Kim, Yi-Jun Kim
PURPOSE: To evaluate the loco-regional recurrence (LRR) rate after breast-conserving surgery without postoperative radiotherapy (RT) for ductal carcinoma in situ (DCIS) of the breast. METHODS: Between 2000 and 2010, 311 DCIS patients from 9 institutions were analyzed retrospectively. The median age was 47 (range, 20-82). The median tumor size was 7 mm (range, 0.01-76). Margin width was <1 cm in 85 patients (27.3%), and nuclear grade was high in 37 patients (11...
January 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28078491/prognostic-factors-in-early-breast-cancer-associated-with-body-mass-index-physical-functioning-physical-activity-and-comorbidity-data-from-a-nationwide-danish-cohort
#9
Trine L Guldberg, Søren Christensen, Robert Zachariae, Anders Bonde Jensen
PURPOSE: To explore the associations between lifestyle-related factors and tumor-related prognostic factors in women treated for primary breast cancer, and to detect possible differences between the associations in pre- and postmenopausal women. METHODS: Associations between tumor-related prognostic factors, including the composite endpoint risk of recurrence (RoR), body mass index (BMI), comorbidity (Charlson comorbidity index), basic physical functioning (SF-36), physical activity, smoking, and alcohol consumption were examined with binary logistic regression analysis in a national cohort of 4917 women treated for primary breast cancer...
January 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28070767/strut-adjusted-volume-implant-savi-brachytherapy-based-accelerated-partial-breast-irradiation-apbi-in-african-american-women
#10
Amir Isbell, Jacquelyn Dunmore-Griffith, Olubunmi Abayomi
PURPOSE: To examine the clinical outcomes of postmenopausal African American (AA) women treated with strut-adjusted volume implant brachytherapy-based accelerated partial breast irradiation for early-stage node-negative breast cancer. METHODS: From January 2011 through April 2015, a total of 50 AA patients, meeting criteria to receive APBI as defined by the National Surgical Adjuvant Breast and Bowel Project B-39 (NASBP B-39), completed treatment with the SAVI breast brachytherapy device at Howard University Hospital...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28066861/the-incidence-of-cardiomyopathy-in-brca1-and-brca2-mutation-carriers-after-anthracycline-based-adjuvant-chemotherapy
#11
Edward J Pearson, Anju Nair, Yahya Daoud, Joanne L Blum
PURPOSE: Breast cancer remains the fourth-leading cause of death in the United States. Nearly 10% of breast cancers are hereditary, with deleterious mutations in BRCA1 and BRCA2 genes being the leading cause. Anthracycline chemotherapy, used commonly for breast cancer, carries cardiotoxicity risk. Recent studies demonstrated anthracycline-induced cardiac failure in homozygous BRCA2-deficient mice and increased rates of heart failure in homozygous BRCA1-deficient mice following ischemic insult...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28064383/algorithms-for-prediction-of-the-oncotype-dx-recurrence-score-using-clinicopathologic-data-a-review-and-comparison-using-an-independent-dataset
#12
REVIEW
Michael R Harowicz, Timothy J Robinson, Michaela A Dinan, Ashirbani Saha, Jeffrey R Marks, P Kelly Marcom, Maciej A Mazurowski
PURPOSE: Given the potential savings in cost and resource utilization, several algorithms have been proposed to predict Oncotype DX recurrence score (ODX RS) using commonly acquired histopathologic variables. Although it is promising, additional independent validation of these surrogate markers is needed prior to guide the patient management. METHODS: In this retrospective study, we analyzed 305 patients with invasive breast cancer at our institution who had ODX RS available...
January 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062982/psychiatric-comorbidities-among-breast-cancer-survivors-in-south-korea-a-nationwide-population-based-study
#13
Jaesung Heo, Mison Chun, Young-Taek Oh, O Kyu Noh, Logyoung Kim
PURPOSE: The aim of this study was to analyze the prevalence of mental disorders in breast cancer survivors using claims data from the Health Insurance Review and Assessment Service in South Korea. We also analyzed patterns of mental disorders with respect to the time of diagnosis and age. MATERIALS AND METHODS: We confirmed mental disorders in a nationwide cohort of 87,843 people who were diagnosed with invasive breast cancer and underwent surgery between January 1, 2010 and December 31, 2014...
January 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062981/body-size-from-birth-through-adolescence-in-relation-to-risk-of-benign-breast-disease-in-young-women
#14
Catherine S Berkey, Bernard Rosner, Rulla M Tamimi, Walter C Willett, Martha Hickey, Adetunji Toriola, A Lindsay Frazier, Graham A Colditz
PURPOSE: Body size, from birth throughout adulthood, is associated with breast cancer risk, but few studies have investigated early-life body size and benign breast disease (BBD), a well-established breast cancer risk factor. We consider whether prenatal factors and size at birth, 10, 18 year, and intervening growth, are related to BBD risk. METHODS: The Growing Up Today Study includes 9032 females who completed questionnaires annually from 1996 to 2001, then 2003, 2005, 2007, 2010, and 2013...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062980/assessment-of-an-apobec3b-truncating-mutation-c-783delg-in-patients-with-breast-cancer
#15
Hoda Radmanesh, Tessa Spethmann, Julia Enßen, Peter Schürmann, Sabin Bhuju, Robert Geffers, Natalia Antonenkova, Elza Khusnutdinova, Ariane Sadr-Nabavi, Fatemeh Homaei Shandiz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen, Natalia Bogdanova, Thilo Dörk
PURPOSE: APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk. METHODS: We performed exome sequencing on genomic DNA samples of 6 Byelorussian patients with familial breast cancer...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062979/contemporary-indications-for-diagnostic-open-biopsy-in-women-assessed-for-screen-detected-breast-lesions-a-ten-year-single-institution-series-of-814-consecutive-cases
#16
Gelareh Farshid, P Grantley Gill
PURPOSE: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives. METHODS: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28062977/angiopoietin-pathway-gene-expression-associated-with-poor-breast-cancer-survival
#17
Rajesh Ramanathan, Amy L Olex, Mikhail Dozmorov, Harry D Bear, Leopoldo Jose Fernandez, Kazuaki Takabe
PURPOSE: Angiogenesis is one of the hallmarks of cancer and is essential for cancer progression and metastasis. However, clinical trials with vascular endothelial growth factor (VEGF) pathway inhibitors have failed to show overall survival benefit in breast cancer. Targeted therapy against the angiopoietin pathway, a downstream angiogenesis cascade, could be effective in breast cancer. This study investigates the association of angiopoietin pathway gene expression with breast cancer survival using a "big data" approach employing RNA sequencing data from The Cancer Genome Atlas (TCGA)...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28058579/prognostic-significance-of-s100a4-expression-and-subcellular-localization-in-early-stage-breast-cancer
#18
Eivind Valen Egeland, Kjetil Boye, Daehoon Park, Marit Synnestvedt, Torill Sauer, Bjørn Naume, Elin Borgen, Gunhild M Mælandsmo
PURPOSE: Prognostic factors are useful in order to identify early-stage breast cancer patients who might benefit from adjuvant treatment. The metastasis-promoting protein S100A4 has previously been associated with poor prognosis in breast cancer patients. The protein is expressed in diverse subcellular compartments, including the cytoplasm, extracellular space, and nucleus. Nuclear expression is an independent predictor of poor outcome in several cancer types, but the significance of subcellular expression has not yet been assessed in breast cancer...
January 5, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28058578/pd-l1-expression-and-tumor-infiltrating-pd-1-%C3%A2-lymphocytes-associated-with-outcome-in-her2-%C3%A2-breast-cancer-patients
#19
Julia Y S Tsang, Wai-Ling Au, Kwan-Yin Lo, Yun-Bi Ni, Thazin Hlaing, Jintao Hu, Siu-Ki Chan, Kui-Fat Chan, Sai-Yin Cheung, Gary M Tse
PURPOSE: Clinical trials showing programmed death (PD)-1-PD-ligand 1 (L1) axis as a promising therapeutic target in melanoma and non-small cell lung cancers have made the pathway a focus of recent attention. However, the data regarding PD-L1/PD-1 in breast cancer are inconsistent. Given the heterogeneity of breast cancers, the clinical relevance of PD-L1 and PD-1 tumor infiltrating lymphocytes (TIL) may vary according to subtypes of breast cancer. We aim to investigate PD-L1 expression in a large cohort of breast cancers and analyze its clinico-pathological as well as outcome relationship according to molecular subtypes...
January 5, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28044214/associations-of-obesity-and-physical-activity-with-serum-and-intratumoral-sex-steroid-hormone-levels-among-postmenopausal-women-with-breast-cancer-analysis-of-paired-serum-and-tumor-tissue-samples
#20
Yoichiro Kakugawa, Hiroshi Tada, Masaaki Kawai, Takashi Suzuki, Yoshikazu Nishino, Seiki Kanemura, Takanori Ishida, Noriaki Ohuchi, Yuko Minami
PURPOSE: It has been hypothesized that intratumoral estrogens may play important roles in the growth of breast cancer. However, few studies have investigated such intratumoral hormones, or their association with risk factors of breast cancer. METHODS: In this cross-sectional study, hormone levels in paired serum and tumor tissue samples from 146 postmenopausal women with breast cancer were measured by liquid chromatography-tandem mass spectrometry and compared between estrogen/progesterone (ER/PgR) subtypes...
January 2, 2017: Breast Cancer Research and Treatment
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