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Alternatives to Laboratory Animals: ATLA

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https://www.readbyqxmd.com/read/29313705/harmonisation-of-animal-testing-alternatives-in-china
#1
REVIEW
Shujun Cheng, Xiaoting Qu, Yao Qin
More and more countries are lining up to follow the EU's approach and implement a full ban on the sale of cosmetics that have been tested on animals, which has been the case in the EU since 2013. Besides animal welfare considerations, the need for mutual acceptance of data (MAD) and harmonisation of the global market have made the move toward non-animal testing a desirable general trend for countries worldwide. Over the last 10 years, the concept of alternative methods has been gradually developing in China...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29313704/fetal-bovine-serum-fbs-a-pain-in-the-dish
#2
Jan van der Valk, Gerhard Gstraunthaler
The use of Fetal Bovine Serum in replacement alternative methods is associated with serious animal welfare concerns, as well as worrying reproducibility issues.
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29313703/the-use-of-gatekeeping-procedures-in-the-statistical-planning-of-animal-experiments
#3
Benjamin Mayer, Vicky Stahl, Martina Kron
Statistical sample size calculation is essential when planning animal experiments in basic medical research. Usually, such trials involve the testing of multiple hypotheses, and interpreting them in a confirmative manner would require the appropriate adjustment of the Type 1 error. This has to be taken into account as early as possible during sample size estimation - otherwise, all the results obtained would be exploratory, i.e. without cogency. In this paper, the concept of gatekeeping is introduced, along with alternative approaches for Type 1 error adjustment...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29313702/a-comparison-of-scaffold-free-and-scaffold-based-reconstructed-human-skin-models-as-alternatives-to-animal-use
#4
Beste Kinikoglu
Tissue engineered full-thickness human skin substitutes have various applications in the clinic and in the laboratory, such as in the treatment of burns or deep skin defects, and as reconstructed human skin models in the safety testing of drugs and cosmetics and in the fundamental study of skin biology and pathology. So far, different approaches have been proposed for the generation of reconstructed skin, each with its own advantages and disadvantages. Here, the classic tissue engineering approach, based on cell-seeded polymeric scaffolds, is compared with the less-studied cell self-assembly approach, where the cells are coaxed to synthesise their own extracellular matrix (ECM)...
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29313701/does-the-stress-inherent-to-laboratory-life-and-experimentation-on-animals-adversely-affect-research-data
#5
EDITORIAL
Jarrod Bailey
No abstract text is available yet for this article.
December 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112455/on-the-journey-toward-humane-education-in-brazil-first-request-for-a-total-ban-of-harmful-animal-use-in-professional-and-higher-education
#6
REVIEW
Róber Bachinski, Gutemberg Alves, Mariângela Freitas de Almeida Souza, Vanessa Carli Bones, Rita de Cassia Maria Garcia, Rosangela Gebara, Valeska Regina Reque Ruiz, Luciano da Silva Alonso, Thales Tréz, Simone Tostes Oliveira, Alexandro Aluisio Rocha, Rita Leal Paixão, Roseli Pizzigatti Klein, Débora Gasparetto, Nick Jukes, Júlia Maria Matera
The Brazilian Network for Humane Education (RedEH( is an independent and self-managed group comprised of academics from ten different Brazilian states and a number of international collaborators. In 2016, in a concerted effort to change the educational field in Brazil and propagate humane education, RedEH sent a request to the Brazilian National Council for the Control of Animal Experimentation (CONCEA(, asking that harmful animal use in education in professional and undergraduate courses be banned. This was the first formal request for a total replacement of harmful animal use in education in Brazil, and represented a major historic landmark in the advancement of Brazilian science education...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112454/training-and-good-science-are-the-foundation-stones-for-animal-replacement
#7
REVIEW
Kelly S Davidge, J Malcolm Wilkinson
Good science, the training of energetic and enthusiastic young researchers, and the experience of industry veterans, will all be needed to drive the implementation and regulatory approval of animal replacement methods in industry.
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112453/new-animal-free-concepts-and-test-methods-for-developmental-toxicity-and-peripheral-neurotoxicity
#8
Marcel Leist
The complex toxicological fields of repeat dose organ toxicity (RDT) and developmental and reproductive toxicity (DART) still require new concepts and approaches to achieve a fully animal-free safety assessment of chemicals. One novel approach is the generation of relevant human cell types from pluripotent stem cells, and the use of such cells for the establishment of phenotypic test methods. Due to their broad endpoints, such tests capture multiple types of toxicants, i.e. they are a readout for the activation of many adverse outcome pathways (AOPs)...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112452/high-throughput-prediction-of-nephrotoxicity-in-humans
#9
Lit-Hsin Loo, Daniele Zink
The Lush Science Prize 2016 was awarded to Daniele Zink and Lit-Hsin Loo for the interdisciplinary and collaborative work between their research groups in developing alternative methods for the prediction of nephrotoxicity in humans. The collaboration has led to the establishment of a series of pioneering alternative methods for nephrotoxicity prediction, which includes: predictive gene expression markers based on pro-inflammatory responses; predictive in vitro cellular models based on pluripotent stem cell-derived proximal tubular-like cells; and predictive cellular phenotypic markers based on chromatin and cytoskeletal changes...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112451/2016-lush-science-prize
#10
Jenny McCann, Terry McCann
The Lush Prize supports animal-free testing by awarding monetary prizes totalling £250,000 to the most effective projects and individuals who have been working toward the goal of replacing animals in product or ingredient safety testing. Prizes are awarded for developments in five strategic areas: Science; Lobbying; Training; Public Awareness; and Young Researchers. In the event of a major breakthrough leading to the replacement of animal tests in the area of 21st Century Toxicology, a Black Box Prize (equivalent to the entire annual fund of £250,000) is awarded...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29112450/the-2016-lush-prize-awards
#11
EDITORIAL
Kelly A BéruBé, Craig Redmond
No abstract text is available yet for this article.
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28994300/in-vitro-models-as-a-platform-to-investigate-traumatic-brain-injury
#12
REVIEW
Ashwin Kumaria
Traumatic Brain Injury (TBI) remains a significant cause of mortality and morbidity, affecting individuals of all age groups. Much remains to be learned about its complex pathophysiology, with a view to designing effective neuroprotective strategies to protect sublethally injured brain tissue that would otherwise die in secondary injury processes. Experimental in vivo models offer the potential to study TBI in the laboratory, however, treatments that were neuroprotective in animals have, thus far, largely failed to translate in human clinical studies...
September 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28994299/use-of-the-bovine-udder-skin-model-to-evaluate-the-tolerability-of-mesem-cosmetic-cream
#13
Christa Raak, Friedrich Molsberger, Wolfgang Pittermann, Mathias Bertram, Sibylle Robens, Thomas Ostermann
Observational studies of Mesem cream (based on Mesembryanthemum crystallinum L. plant extract) found that it had positive effects on skin hydration and smoothing of the skin. However, some patients reported skin irritation effects. The current study evaluated the skin tolerability of Mesem cream, as compared to the carrier cream (without the active ingredient), by using the isolated perfused bovine udder skin model. The primary outcomes investigated were cytotoxicity (i.e. cell viability), assessed with the MTT assay, and irritancy and inflammation, assessed by measuring PGE₂ tissue levels...
September 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28994298/human-aortic-endothelial-cells-respond-to-shear-flow-in-well-plate-microfluidic-devices
#14
Om Makwana, Hannah Flockton, Gary P Watters, Rizwan Nisar, Gina A Smith, Wanda Fields, Betsy Bombick
Although chronic progressive cardiovascular diseases such as atherosclerosis are often challenging to fully model in vitro, it has been shown that certain in vitro methods can effectively evaluate some aspects of disease progression. This has been demonstrated in in vitro and in vivo studies of endothelial cells that have illustrated the effects of nitric oxide (NO) production, filamentous actin (F-actin) formation, and cell and actin angle alignment on vascular function and homeostasis. Systems utilising shear flow have been established, in order to create a physiologically relevant environment for cells that require shear flow for homeostasis...
September 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28994297/some-personal-reminiscences-of-the-long-road-to-acceptance-of-the-three-rs
#15
EDITORIAL
Michael Balls
No abstract text is available yet for this article.
September 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816056/letter-to-the-editor
#16
LETTER
Jarrod Bailey
No abstract text is available yet for this article.
July 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816055/pain-in-laboratory-animals-a-possible-confounding-factor
#17
Lynne U Sneddon
Reducing pain in animals is an ethical and sometimes legal requirement, but how do we assess pain and does it confound data collection?
July 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816054/animal-models-how-a-mechanistic-approach-can-reduce-suffering-and-improve-translatability
#18
Elliot Lilley
Poorly predictive animal models of disease cause avoidable suffering and hamper the discovery of new treatments for patients. A focus on mechanistic modelling has the potential to reduce animal suffering as well as improving translation from the bench to the bedside.
July 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816053/in-vitro-exposure-systems-and-dosimetry-assessment-tools-for-inhaled-tobacco-products-workshop-proceedings-conclusions-and-paths-forward-for-in-vitro-model-use
#19
Holger Behrsing, Erin Hill, Hans Raabe, Raymond Tice, Suzanne Fitzpatrick, Robert Devlin, Kent Pinkerton, Günter Oberdörster, Chris Wright, Roman Wieczorek, Michaela Aufderheide, Sandro Steiner, Tobias Krebs, Bahman Asgharian, Richard Corley, Michael Oldham, Jason Adamson, Xiang Li, Irfan Rahman, Sonia Grego, Pei-Hsuan Chu, Shaun McCullough, Rodger Curren
In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 4-6 April 2016, the Institute for In Vitro Sciences, Inc. (IIVS) convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities articulated by the FDA CTP...
July 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28816052/animal-experiments-and-the-right-to-ask-questions-about-them
#20
EDITORIAL
Michael Balls
No abstract text is available yet for this article.
July 2017: Alternatives to Laboratory Animals: ATLA
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