journal
MENU ▼
Read by QxMD icon Read
search

Alternatives to Laboratory Animals: ATLA

journal
https://www.readbyqxmd.com/read/28598195/white-paper-and-colourful-language-toward-a-realistic-view-of-animal-research
#1
Herwig Grimm, Matthias Eggel
No abstract text is available yet for this article.
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28598194/the-use-of-neurocomputational-models-as-alternatives-to-animal-models-in-the-development-of-electrical-brain-stimulation-treatments
#2
Anne Beuter
Recent publications call for more animal models to be used and more experiments to be performed, in order to better understand the mechanisms of neurodegenerative disorders, to improve human health, and to develop new brain stimulation treatments. In response to these calls, some limitations of the current animal models are examined by using Deep Brain Stimulation (DBS) in Parkinson's disease as an illustrative example. Without focusing on the arguments for or against animal experimentation, or on the history of DBS, the present paper argues that given recent technological and theoretical advances, the time has come to consider bioinspired computational modelling as a valid alternative to animal models, in order to design the next generation of human brain stimulation treatments...
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28598193/sample-size-estimation-for-pilot-animal-experiments-by-using-a-markov-chain-monte-carlo-approach
#3
Andreas Allgoewer, Benjamin Mayer
The statistical determination of sample size is mandatory when planning animal experiments, but it is usually difficult to implement appropriately. The main reason is that prior information is hardly ever available, so the assumptions made cannot be verified reliably. This is especially true for pilot experiments. Statistical simulation might help in these situations. We used a Markov Chain Monte Carlo (MCMC) approach to verify the pragmatic assumptions made on different distribution parameters used for power and sample size calculations in animal experiments...
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28598192/evaluation-of-a-human-neural-stem-cell-culture-method-for-prediction-of-the-neurotoxicity-of-anti-epileptics
#4
Abdal-Jabbar Al-Rubai, Peter Wigmore, Margaret K Pratten
Human neural stem cells have been proposed as an in vitro model to predict neurotoxicity. In this study, the potential of in vitro cultures of human-derived neurospheres to predict the effects of various anti-epileptic drugs (sodium valproate, phenytoin, carbamazepine and phenobarbitone) was evaluated. In general, these drugs had no significant effects on cell viability, total cellular protein, and neuronal process length at low doses, but at high doses these parameters were reduced significantly. Therapeutic doses of sodium valproate and phenytoin had a clear effect on neurosphere size and cell migration, with a significant reduction in both parameters when compared with the control group...
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28598191/no-time-like-the-present-two-hundred-years-of-parkinson-s-disease
#5
EDITORIAL
Robert Combes
No abstract text is available yet for this article.
May 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28409997/launch-of-the-alliance-for-human-relevant-science
#6
Rebecca Ram
No abstract text is available yet for this article.
March 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28409996/the-use-of-animals-in-medical-research-a-historical-perspective
#7
Jolanta Zwolińska
No abstract text is available yet for this article.
March 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28409995/the-perception-of-animal-experimentation-ethics-among-indian-teenage-school-pupils
#8
Justin Namuk Kim, Eun Hee Choi, Soo-Ki Kim
To promote awareness of animal experimentation ethics among teenagers, we created an educational pamphlet and an accompanying questionnaire. One hundred Indian teenage school pupils were given the pamphlet and subsequently surveyed with the questionnaire, to evaluate: a) their perception of animal experimentation ethics; and b) their opinion on the effectiveness of the pamphlet, according to gender and school grade/age. There was a significant correlation between grade/age and support for animal experimentation, i...
March 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28409994/a-novel-porcine-ex-vivo-retina-culture-model-for-oxidative-stress-induced-by-h%C3%A2-o%C3%A2
#9
José Hurst, Sandra Kuehn, Adelina Jashari, Teresa Tsai, Karl Ulrich Bartz-Schmidt, Sven Schnichels, Stephanie C Joachim
Oxidative stress is a key player in many ophthalmic diseases. However, the role of oxidative stress in most degenerative processes is not yet known. Therefore, accurate and practical models are required to efficiently screen for therapeutics. Porcine eyes are closely related to the human eye, and can be obtained from the abattoir as a by-product of the food industry. Therefore, they offer excellent opportunities for the development of culture models with which to pre-screen potential therapies, while reducing the use of laboratory animals...
March 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28409993/animal-experimentation-and-alternatives-revealed-preferences
#10
EDITORIAL
Michael Balls, Robert Combes
No abstract text is available yet for this article.
March 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28094537/statistics-of-scientific-procedures-on-living-animals-great-britain-2015-highlighting-an-ongoing-upward-trend-in-animal-use-and-missed-opportunities
#11
Michelle Hudson-Shore
The Annual Statistics of Scientific Procedures on Living Animals Great Britain 2015 indicate that the Home Office were correct in recommending that caution should be exercised when interpreting the 2014 data as an apparent decline in animal experiments. The 2015 report shows that, as the changes to the format of the annual statistics have become more familiar and less problematic, there has been a re-emergence of the upward trend in animal research and testing in Great Britain. The 2015 statistics report an increase in animal procedures (up to 4,142,631) and in the number of animals used (up to 4,069,349)...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28094536/the-novel-induction-of-retinal-ganglion-cell-apoptosis-in-porcine-organ-culture-by-nmda-an-opportunity-for-the-replacement-of-animals-in-experiments
#12
Sandra Kuehn, Jose Hurst, Adelina Jashari, Kathrin Ahrens, Teresa Tsai, Ilan M Wunderlich, H Burkhard Dick, Stephanie C Joachim, Sven Schnichels
Some of the advantages of retina organ culture models include their efficient and easy handling and the ability to standardise relevant parameters. Additionally, when porcine eyes are obtained from the food industry, no animals are killed solely for research purposes. To induce retinal degeneration, a commonly used toxic substance, N-methyl-D-aspartate (NMDA), was applied to the cultures. To this end, organotypic cultures of porcine retinas were cultured and treated with different doses of NMDA (0 [control], 50, 100 and 200μM) on day 2 for 48 hours...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28094535/comparing-the-coral-and-random-forest-approaches-for-modelling-the-in-vitro-cytotoxicity-of-silica-nanomaterials
#13
COMPARATIVE STUDY
Antonio Cassano, Richard L Marchese Robinson, Anna Palczewska, Tomasz Puzyn, Agnieszka Gajewicz, Lang Tran, Serena Manganelli, Mark T D Cronin
Nanotechnology is one of the most important technological developments of the 21st century. In silico methods to predict toxicity, such as quantitative structure-activity relationships (QSARs), promote the safe-by-design approach for the development of new materials, including nanomaterials. In this study, a set of cytotoxicity experimental data corresponding to 19 data points for silica nanomaterials were investigated, to compare the widely employed CORAL and Random Forest approaches in terms of their usefulness for developing so-called 'nano-QSAR' models...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28094534/in-vitro-assessment-of-skin-irritation-potential-of-surfactant-based-formulations-by-using-a-3-d-skin-reconstructed-tissue-model-and-cytokine-response
#14
Russel M Walters, Lisa Gandolfi, M Catherine Mack, Michael Fevola, Katharine Martin, Mathew T Hamilton, Allison Hilberer, Nicole Barnes, Nathan Wilt, Jennifer R Nash, Hans A Raabe, Gertrude-Emilia Costin
The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and clinical testing before becoming available for consumer use on skin. In vitro systems based on skin reconstructed equivalents are now established for the preclinical assessment of product irritation potential and as alternative testing methods to the classic Draize rabbit skin irritation test. We have used the 3-D EpiDerm™ model system to evaluate tissue viability and primary cytokine interleukin-1α release as a way to evaluate the potential dermal irritation of 224 non-ionic, amphoteric and/or anionic surfactant-containing formulations, or individual raw materials...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28094533/animal-experimentation-the-statistics-speak-for-themselves
#15
EDITORIAL
Michael Balls, Robert Combes
No abstract text is available yet for this article.
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27805832/a-multi-faceted-approach-to-achieving-the-global-acceptance-of-animal-free-research-methods
#16
REVIEW
Jodie Melbourne, Patricia Bishop, Jeffrey Brown, Gilly Stoddart
In 2015, the PETA International Science Consortium Ltd. was awarded the Lush Training Prize for its broad approach to education and training on the effective use of human-relevant, non-animal research techniques. The prize was awarded for work that included hosting workshops and webinars, initiating in-person training sessions and developing educational resources. The Consortium works closely with industry and regulatory agencies to identify and overcome barriers to the validation and use of alternatives to animal testing, by using an approach that identifies, promotes and verifies the implementation of these methods...
October 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27805831/establishment-of-a-tumour-stroma-airway-model-oncocilair-to-accelerate-the-development-of-human-therapies-against-lung-cancer
#17
REVIEW
Christophe Mas, Bernadett Boda, Mireille Caul Futy, Song Huang, Ludovic Wisniewski, Samuel Constant
This paper highlights the work for which OncoTheis, a Swiss biotechnology company, engaged in the development of innovative bioengineered tissues and organoids for cancer research, was co-awarded the 2015 Lush Science Prize. Noting that the use of animal models failed to lead to the design of effective treatments for cancer, OncoTheis has opted to develop in vitro models based exclusively on human cells. The company currently focuses on lung cancer, which is the leading cause of cancer-related deaths worldwide, with more than one million deaths per year...
October 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27805830/body-on-a-chip-systems-for-animal-free-toxicity-testing
#18
REVIEW
Gretchen J Mahler, Mandy B Esch, Tracy Stokol, James J Hickman, Michael L Shuler
Body-on-a-chip systems replicate the size relationships of organs, blood distribution and blood flow, in accordance with human physiology. When operated with tissues derived from human cell sources, these systems are capable of simulating human metabolism, including the conversion of a prodrug to its effective metabolite, as well as its subsequent therapeutic actions and toxic side-effects. The system also permits the measurement of human tissue electrical and mechanical reactions, which provide a measure of functional response...
October 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27805829/2015-lush-science-prize
#19
REVIEW
Jenny McCann, Terry McCann
The Lush Prize supports animal-free testing by rewarding the most effective projects and individuals who have been working toward the goal of replacing animals in product or ingredient safety testing. Prizes are awarded for developments in five strategic areas: Science; Lobbying; Training; Public Awareness; and Young Researchers. Should there be a major breakthrough in 21st century toxicology, a Black Box Prize equivalent to the entire annual fund of £250,000 is awarded. A Background Paper is prepared each year, prior to the judging process, to provide the panel with a brief overview of current developments in the field of Replacement alternatives, particularly those relevant to the concept of toxicity pathways...
October 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/27805828/the-adverse-outcome-pathway-for-skin-sensitisation-moving-closer-to-replacing-animal-testing
#20
REVIEW
Terry W Schultz, Gergana Dimitrova, Sabcho Dimitrov, Ovanes G Mekenyan
This article outlines the work of the Organisation for Economic Co-operation and Development (OECD) that led to being jointly awarded the 2015 Lush Black Box Prize. The award-winning work centred on the development of 'The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins'. This Adverse Outcome Pathway (AOP) has provided the mechanistic basis for the integration of skin sensitisation-related information. Recent developments in integrated approaches to testing and assessment, based on the AOP, are summarised...
October 2016: Alternatives to Laboratory Animals: ATLA
journal
journal
28238
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"