journal
MENU ▼
Read by QxMD icon Read
search

Antiviral Research

journal
https://www.readbyqxmd.com/read/28535933/anti-inflammatory-effects-of-adjunctive-macrolide-treatment-in-adults-hospitalized-with-influenza-a-randomized-controlled-trial
#1
Nelson Lee, Chun-Kwok Wong, Martin C W Chan, Esther S L Yeung, Wilson W S Tam, Owen T Y Tsang, Kin-Wing Choi, Paul K S Chan, Angela Kwok, Grace C Y Lui, Wai-Shing Leung, Irene M H Yung, Rity Y K Wong, Catherine S K Cheung, David S C Hui
INTRODUCTION: - Macrolides can ameliorate inflammation in respiratory diseases, providing clinical benefits. Data in influenza is lacking. METHOD: - A randomized, open-label, multicenter trial among adults hospitalized for laboratory-confirmed influenza was conducted. Study treatments of oseltamivir and azithromycin (500 mg/day), or oseltamivir alone, both for 5 days, were allocated at 1:1 ratio. The primary outcome was plasma cytokine/chemokine concentration change over time (Day 0-10); secondary outcomes were viral load and symptom score changes...
May 20, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28529001/a-single-intranasal-administration-of-virus-like-particle-vaccine-induces-an-efficient-protection-for-mice-against-human-respiratory-syncytial-virus
#2
Yue-Ying Jiao, Yuan-Hui Fu, Yi-Fei Yan, Ying Hua, Yao Ma, Xiu-Juan Zhang, Jing-Dong Song, Xiang-Lei Peng, Jiaqiang Huang, Tao Hong, Jin-Sheng He
Human respiratory syncytial virus (RSV) is an important pediatric pathogen causing acute viral respiratory disease in infants and young children. However, no licensed vaccines are currently available. Virus-like particles (VLPs) may bring new hope to producing RSV VLP vaccine with high immunogenicity and safety. Here, we constructed the recombinants of matrix protein (M) and fusion glycoprotein (F) of RSV, respectively into a replication-deficient first-generation adenoviral vector (FGAd), which were used to co-infect Vero cells to assemble RSV VLPs successfully...
May 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28529000/preclinical-evaluation-of-vis513-a-therapeutic-antibody-against-dengue-virus-in-non-human-primates
#3
Eugenia Z Ong, Yadunanda Budigi, Hwee Cheng Tan, Luke N Robinson, Kirk J Rowley, Alexander Winnett, Sven Hobbie, Zachary Shriver, Gregory J Babcock, Eng Eong Ooi
Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and virological endpoints to guide the design of human trials of VIS513, a pan-serotype anti-DENV IgG1 antibody, in non-human primates (NHPs). Dosing VIS513 pre- or post-peak viremia in NHPs neutralized infectious DENV although RNAemia remained detectable post-treatment; differential interaction of human IgGs with macaque Fc-gamma receptors may delay clearance of neutralized DENV...
May 18, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28511994/study-of-rubella-candidate-vaccine-based-on-a-structurally-modified-plant-virus
#4
Ekaterina A Trifonova, Vladimir A Zenin, Nikolai A Nikitin, Maria S Yurkova, Ekaterina M Ryabchevskaya, Egor V Putlyaev, Ekaterina K Donchenko, Olga A Kondakova, Alexey N Fedorov, Joseph G Atabekov, Olga V Karpova
A novel rubella candidate vaccine based on a structurally modified plant virus - spherical particles (SPs) - was developed. SPs generated by the thermal remodelling of the tobacco mosaic virus are promising platforms for the development of vaccines. SPs combine unique properties: biosafety, stability, high immunogenicity and the effective adsorption of antigens. We assembled in vitro and characterised complexes (candidate vaccine) based on SPs and the rubella virus recombinant antigen. The candidate vaccine induced a strong humoral immune response against rubella...
May 13, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28501424/ro0504985-is-an-inhibitor-of-cmgc-kinase-proteins-and-has-anti-human-cytomegalovirus-activity
#5
Blair L Strang
Public-private partnerships allow many previously unavailable compounds to be screened for antiviral activity. Here a screening method was used to identify an oxindole compound, RO0504985, from a Roche kinase inhibitor library that inhibited human cytomegalovirus (HCMV) protein production. RO0504985 was previously described as an inhibitor of cyclin-dependent kinase 2 (CDK2). However, using kinase selectivity assays it was found that RO0504985 was an inhibitor of several CMGC group kinase proteins, including CDK2...
May 10, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28499864/role-of-hepatitis-b-core-protein-in-hbv-transcription-and-recruitment-of-histone-acetyltransferases-to-cccdna-minichromosome
#6
Chun Kong Chong, Ching Yan Serene Cheng, Sin Yi Jasmine Tsoi, Fung-Yu Huang, Fen Liu, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen, Danny Ka-Ho Wong
The hepatitis B core protein (HBc) has been suggested to interact with covalently closed circular DNA (cccDNA) and regulate hepatitis B virus (HBV) transcription. However, direct evidence is lacking. We aimed to identify the specific HBc region(s) responsible for transcription regulation and its interaction with cccDNA. Seventeen mutants with mutations at the four arginine-rich clusters of the HBc carboxyl-terminal domain (CTD) were created. The effect of HBc mutations on the levels of HBV DNA, RNA, and hepatitis B surface antigen (HBsAg) were measured...
May 10, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28495463/development-of-an-animal-model-of-progressive-vaccinia-in-nu-nu-mice-and-the-use-of-bioluminescence-imaging-for-assessment-of-the-efficacy-of-monoclonal-antibodies-against-vaccinial-b5-and-l1-proteins
#7
Marina Zaitseva, Antonia Thomas, Clement A Meseda, Charles Y K Cheung, Claudia G Diaz, Yan Xiang, Shane Crotty, Hana Golding
Bioluminescence imaging (BLI) was used to follow dissemination of recombinant vaccinia virus (VACV) expressing luciferase (IHD-J-Luc) in BALB/c nu/nu mice treated post-challenge with monoclonal antibodies (MAbs) against L1 and B5 VACV proteins in a model of Progressive Vaccinia (PV). Areas Under the flux Curve (AUC) were calculated for viral loads in multiple organs in individual mice. Following scarification with 10(5) pfu, IHD-J-Luc VACV undergoes fast replication at the injection site and disseminates rapidly to the inguinal lymph nodes followed by spleen, liver, and axillary lymph nodes within 2-3 days and before primary lesions are visible at the site of scarification...
May 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28483551/antiviral-activity-of-formyl-peptide-receptor-2-antagonists-against-influenza-viruses
#8
Noémie Courtin, Aurélien Fotso Fotso, Pierre Fautrad, Floriane Mas, Marie-Christine Alessi, Béatrice Riteau
Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation...
May 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28465147/immunoprotection-induced-by-cpg-odn-poly-i-c-combined-with-recombinant-gp90-protein-in-chickens-against-reticuloendotheliosis-virus-infection
#9
Fei Yuan, Ying Chu, Lihong Qi, Hongmei Li, Shuhong Sun, Peng Zhao, Shuang Chang, Huijun Guo
The present study is focused on investigating the immunoprotective effects of CpG-ODN/Poly(I:C) combined with the viral glycoprotein gp90 protein against reticuloendotheliosis virus (REV) infection in chickens. REV's gp90 gene was amplified from the REV-infected cells and expressed in Escherichia coli (E.coli). The expressed products, upon purification, were inoculated into 7-day-old chickens with PBS, CpG-ODN or Poly(I:C) adjuvant; Two booster inoculations were then conducted, and then each chicken was challenged...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28465146/antiviral-activity-of-favipiravir-t-705-against-mammalian-and-avian-bornaviruses
#10
Tomoya Tokunaga, Yusuke Yamamoto, Madoka Sakai, Keizo Tomonaga, Tomoyuki Honda
Bornaviruses, non-segmented, negative-strand RNA viruses, are emerging agents with the potential for causing various types of neurological symptoms. Previous studies have shown that ribavirin, a nucleic acid analog with broad-spectrum antiviral activity, has a potent antiviral effect on infections with a mammalian bornavirus, Borna disease virus (BoDV-1), as well as avian bornaviruses. However, ribavirin-based treatment does not eliminate bornaviruses from persistently infected cells and viral replication resumes after treatment cessation...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28461072/anti-inflammatory-effects-of-rosmarinic-acid-4-o-%C3%AE-d-glucoside-in-reducing-acute-lung-injury-in-mice-infected-with-influenza-virus
#11
Jian-Xing Liu, Ying Zhang, Qiu-Ping Hu, Ji-Qiang Li, Yun-Tao Liu, Qing-Guang Wu, Jian-Guo Wu, Xiao-Ping Lai, Zhong-de Zhang, Xiong Li, Geng Li
Rosmarinic acid-4-O-β-D-glucoside (RAG) is a dicaffeoyl phenolic compound isolated from Sarcandra glabra (Thunb.) Nakai. Preliminary studies show that RAG has significant anti-inflammatory properties and can alleviate ear swelling in mice and the paw swelling in rats. Here, the anti-influenza effects of RAG were investigated in mice infected with A/FM/1/47 H1N1 virus. The survival rate and body weight were observed, the lung edema, virus copies, inflammatory cytokines (including IL-4, IL-5, TNF-α and IFN-γ) and oxidative damage indexes (including SOD, MDA, NO, and CAT) were measured...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28461069/characterization-of-the-zika-virus-two-component-ns2b-ns3-protease-and-structure-assisted-identification-of-allosteric-small-molecule-antagonists
#12
Sergey A Shiryaev, Chen Farhy, Antonella Pinto, Chun-Teng Huang, Nicole Simonetti, Annie Elong Ngono, Antimone Dewing, Sujan Shresta, Anthony B Pinkerton, Piotr Cieplak, Alex Y Strongin, Alexey V Terskikh
The recent re-emergence of Zika virus (ZIKV)(1), a member of the Flaviviridae family, has become a global emergency. Currently, there are no effective methods of preventing or treating ZIKV infection, which causes severe neuroimmunopathology and is particularly harmful to the developing fetuses of infected pregnant women. However, the pathology induced by ZIKV is unique among flaviviruses, and knowledge of the biology of other family members cannot easily be extrapolated to ZIKV. Thus, structure-function studies of ZIKV proteins are urgently needed to facilitate the development of effective preventative and therapeutic agents...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28461071/host-oxidative-folding-pathways-offer-novel-anti-chikungunya-virus-drug-targets-with-broad-spectrum-potential
#13
Rose M Langsjoen, Albert J Auguste, Shannan L Rossi, Christopher M Roundy, Heidy N Penate, Maria Kastis, Matthew K Schnizlein, Kevin C Le, Sherry L Haller, Rubing Chen, Stanley J Watowich, Scott C Weaver
Alphaviruses require conserved cysteine residues for proper folding and assembly of the E1 and E2 envelope glycoproteins, and likely depend on host protein disulfide isomerase-family enzymes (PDI) to aid in facilitating disulfide bond formation and isomerization in these proteins. Here, we show that in human HEK293 cells, commercially available inhibitors of PDI or modulators thereof (thioredoxin reductase, TRX-R; endoplasmic reticulum oxidoreductin-1, ERO-1) inhibit the replication of CHIKV chikungunya virus (CHIKV) in vitro in a dose-dependent manner...
April 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28461070/suramin-inhibits-zika-virus-replication-by-interfering-with-virus-attachment-and-release-of-infectious-particles
#14
Irina C Albulescu, Kristina Kovacikova, Ali Tas, Eric J Snijder, Martijn J van Hemert
Zika virus (ZIKV) is a mosquito-borne flavivirus that mostly causes asymptomatic infections or mild disease characterized by low-grade fever, rash, conjunctivitis, and malaise. However, the recent massive ZIKV epidemics in the Americas have also linked ZIKV infection to fetal malformations like microcephaly and Guillain-Barré syndrome in adults, and have uncovered previously unrecognized routes of vertical and sexual transmission. Here we describe inhibition of ZIKV replication by suramin, originally an anti-parasitic drug, which was more recently shown to inhibit multiple viruses...
April 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28457855/polysulfonate-suramin-inhibits-zika-virus-infection
#15
Chee Wah Tan, I-Ching Sam, Wei Lim Chong, Vannajan Sanghiran Lee, Yoke Fun Chan
Zika virus (ZIKV) is an arthropod-borne flavivirus that causes newborn microcephaly and Guillian-Barré syndrome in adults. No therapeutics are available to treat ZIKV infection or other flaviviruses. In this study, we explored the inhibitory effect of glycosaminoglycans and analogues against ZIKV infection. Highly sulfated heparin, dextran sulfate and suramin significantly inhibited ZIKV infection in Vero cells. De-sulfated heparin analogues lose inhibitory effect, implying that sulfonate groups are critical for viral inhibition...
April 27, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28454913/coinjection-of-a-vaccine-and-anti-viral-agents-can-provide-fast-acting-protection-from-foot-and-mouth-disease
#16
Su-Hwa You, Taeseong Kim, Joo-Hyung Choi, Gundo Park, Kwang-Nyeong Lee, Byounghan Kim, Myoung-Heon Lee, Hyun-Soo Kim, Su-Mi Kim, Jong-Hyeon Park
Foot-and-mouth disease (FMD) is the cause of an economically devastating animal disease. With commercial inactivated FMD vaccines, the protection against FMD virus (FMDV) begins a minimum of 4 days post vaccination (dpv). Therefore, antiviral agents could be proposed for rapid protection and to reduce the spread of FMDV during outbreaks until vaccine-induced protective immunity occurs. In previous studies, we have developed two recombinant adenoviruses that simultaneously express porcine interferon-α and interferon-γ (Ad-porcine IFN-αγ) and multiple siRNAs that target the non-structural protein-regions of FMDV (Ad-3siRNA), and we have shown that the combination of the two antiviral agents (referred to here as Ad combination) induced robust protection against FMDV in pigs...
April 25, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28454912/phosphonoamidate-prodrugs-of-c5-substituted-pyrimidine-acyclic-nucleosides-for-antiviral-therapy
#17
Fabrizio Pertusati, Sara Serafini, Najmiyah Albadry, Robert Snoeck, Graciela Andrei
Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine acyclic nucleosides derivatives functionalized with but-2-enyl- chain. In the phosphonoamidate series, the most active compound 15, showed sub-micromolar activity against varicella zoster virus (VZV) (EC50 = 0.09-0.5 μM) and μM activity against human cytomegalovirus (HCMV) and herpes simplex virus (HSV)...
April 25, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28450058/inhibition-of-hepatitis-b-virus-replication-by-n-hydroxyisoquinolinediones-and-related-polyoxygenated-heterocycles
#18
Tiffany C Edwards, Elena Lomonosova, Jenny A Patel, Qilan Li, Juan A Villa, Ankit K Gupta, Lynda A Morrison, Fabrice Bailly, Philippe Cotelle, Erofili Giannakopoulou, Grigoris Zoidis, John E Tavis
We previously reported low sensitivity of the hepatitis B virus (HBV) ribonuclease H (RNaseH) enzyme to inhibition by N-hydroxyisoquinolinedione (HID) compounds. Subsequently, our biochemical RNaseH assay was found to have a high false negative rate for predicting HBV replication inhibition, leading to underestimation of the number of HIDs that inhibit HBV replication. Here, 39 HID compounds and structurally related polyoxygenated heterocycles (POH), N-hydroxypyridinediones (HPD), and flutimides were screened for inhibition of HBV replication in vitro...
April 25, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28442428/rapamycin-modulation-of-p70-s6-kinase-signaling-inhibits-rift-valley-fever-virus-pathogenesis
#19
Todd M Bell, Virginia Espina, Svetlana Senina, Caitlin Woodson, Ashwini Brahms, Brian Carey, Shih-Chao Lin, Lindsay Lundberg, Chelsea Pinkham, Alan Baer, Claudius Mueller, Elizabeth A Chlipala, Faye Sharman, Cynthia de la Fuente, Lance Liotta, Kylene Kehn-Hall
Despite over 60 years of research on antiviral drugs, very few are FDA approved to treat acute viral infections. Rift Valley fever virus (RVFV), an arthropod borne virus that causes hemorrhagic fever in severe cases, currently lacks effective treatments. Existing as obligate intracellular parasites, viruses have evolved to manipulate host cell signaling pathways to meet their replication needs. Specifically, translation modulation is often necessary for viruses to establish infection in their host. Here we demonstrated phosphorylation of p70 S6 kinase, S6 ribosomal protein, and eIF4G following RVFV infection in vitro through western blot analysis and in a mouse model of infection through reverse phase protein microarrays (RPPA)...
April 23, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28427827/antiviral-screen-identifies-ev71-inhibitors-and-reveals-camptothecin-target-dna-topoisomerase-1-as-a-novel-ev71-host-factor
#20
Kan Xing Wu, Justin Jang-Hann Chu
Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease (HFMD) associated with severe neurological disease. EV71's pathogenesis remains poorly understood and the lack of approved antiviral has led to its emergence as a clinically important neurotropic virus. The goals of this study were to: (i) identify novel anti-EV71 compounds that may serve as lead molecules for therapeutics; and (ii) investigate their targets in downstream studies. We screened a 502-compound library of highly purified natural products for anti-EV71 activities in a cell-based immunofluorescence assay that were then confirmed in viral plaque reduction assays...
April 17, 2017: Antiviral Research
journal
journal
28222
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"