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Journal of Neuroimmunology

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https://www.readbyqxmd.com/read/29789140/changes-in-concentrations-of-tau-reactive-antibodies-are-dependent-on-sex-in-alzheimer-s-disease-patients
#1
Michala Krestova, Jan Ricny, Ales Bartos
The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We observed higher reactivity of natural tau-reactive antibodies towards phosphorylated bovine tau protein than to human recombinant (non-phosphorylated) tau protein. Males with MCI-AD had higher amounts of these antibodies than corresponding controls. Concentrations of antibodies were lower in females with the MCI-AD than in control females...
May 19, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29752068/tlr4-in-circumventricular-neural-stem-cells-is-a-negative-regulator-for-thermogenic-pathways-in-the-mouse-brain
#2
Shiori Muneoka, Saki Murayama, Yousuke Nakano, Seiji Miyata
Toll-like receptor 4 (TLR4) recognizes bacteria-derived lipopolysaccharide (LPS). In the present study, we found that intraperitoneal LPS activated nuclear factor-κ B (NF-κB) in TLR4-expressing neural stem cells (NSCs) in the circumventricular brain regions of mice. Intracerebroventricular preadministration of low-dose TLR4 inhibitors significantly augmented hyperthermia together with the inhibition of NF-κB activation in circumventricular NSCs of LPS-inflamed animals. Moreover, intracerebroventricular administration of high-dose TLR4 inhibitors induced hyperthermia and Fos activation in circumventricular NSCs and hypothalamic neurons...
May 3, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29729895/implications-of-polymorphonuclear-neutrophils-for-ischemic-stroke-and-intracerebral-hemorrhage-predictive-value-pathophysiological-consequences-and-utility-as-therapeutic-target
#3
REVIEW
Dirk M Hermann, Christoph Kleinschnitz, Matthias Gunzer
Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies, high neutrophil to lymphocyte ratios in peripheral blood are predictive of poor outcome in human stroke patients. Following earlier studies indicating that the cerebral microvasculature forms an efficient barrier that impedes neutrophil brain entry, intravital microscopy and immunohistochemistry in the meantime unequivocally revealed the accumulation of PMN in the ischemic and hemorrhagic brain parenchyma...
April 24, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29681406/sex-influences-in-behavior-and-brain-inflammatory-and-oxidative-alterations-in-mice-submitted-to-lipopolysaccharide-induced-inflammatory-model-of-depression
#4
Bruna Stefânia Ferreira Mello, Adriano José Maia Chaves Filho, Charllyany Sabino Custódio, Rafaela Carneiro Cordeiro, Fabio Miyajima, Francisca Cléa Florenço de Sousa, Silvânia Maria Mendes Vasconcelos, David Freitas de Lucena, Danielle Macedo
Peripheral inflammation induced by lipopolysaccharide (LPS) causes a behavioral syndrome with translational relevance for depression. This mental disorder is twice more frequent among women. Despite this, the majority of experimental studies investigating the neurobiological effects of inflammatory models of depression have been performed in males. Here, we sought to determine sex influences in behavioral and oxidative changes in brain regions implicated in the pathophysiology of mood disorders (hypothalamus, hippocampus and prefrontal cortex - PFC) in adult mice 24 h post LPS challenge...
April 14, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29685330/relation-of-intrathecal-oligoclonal-band-production-to-inflammatory-mediator-and-immunotherapy-response-in-208-children-with-oms
#5
Michael R Pranzatelli, Nathan R McGee, Elizabeth D Tate
In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomarkers. The phenotypes of OCB(+) and OCB(-) patients were not distinctive. CSF B cells were expanded in untreated OMS regardless of OCB positivity. These data reveal a much higher frequency of OCB positivity in untreated OMS than previously realized and a disconnect between intrathecal OCB and inflammatory mediator production...
April 12, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29661540/mif-functional-polymorphisms-794-catt-5-8-and-173-g-c-are-associated-with-mif-serum-levels-severity-and-progression-in-male-multiple-sclerosis-from-western-mexican-population
#6
V A Castañeda-Moreno, U De la Cruz-Mosso, N Torres-Carrillo, M A Macías-Islas, O Padilla-De la Torre, M A Mireles-Ramírez, O González-Pérez, J L Ruiz-Sandoval, M Huerta, X Trujillo, D Ortuño-Sahagún, Muñoz-Valle Jf
Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population. Therefore, we decided to investigate the genetic association of -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms with MS, clinical variables and MIF serum levels in the population of western Mexico...
April 10, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29661538/an-unusual-case-of-anti-mog-cns-demyelination-with-concomitant-mild-anti-nmdar-encephalitis
#7
Jiajia Zhou, Winwen Tan, Suyin Elaine Tan, Jing Hu, Zhongqin Chen, Kang Wang
We report the case of a patient who presented with progressive unsteadiness and narcoleptic attacks followed by behavioral change and psychosis, without visual disturbances or seizures. MRI revealed multiple areas of fluid attenuation inversion recovery (FLAIR) high-intensity lesions involving the cerebellum, brainstem, thalamus and third ventricular peri-ependymal region consistent with demyelination. Both the serum myelin oligodendrocyte glycoprotein-antibodies (MOG-Abs) and cerebral spinal fluid (CSF) anti-N-methyl-d-as-partate receptor (NMDAR) antibodies were positive using transfected cell based assays...
April 6, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29655870/increased-constitutive-activation-of-nf-%C3%AE%C2%BAb-p65-rela-in-peripheral-blood-cells-of-patients-with-progressive-multiple-sclerosis
#8
Jun Yan, Clay M Winterford, Vibeke S Catts, Betty K Pat, Michael P Pender, Pamela A McCombe, Judith M Greer
The NF-κB signalling pathway plays an important role in controlling cellular immune responses, inflammation and apoptosis. In multiple sclerosis (MS), there is evidence of dysregulation of NF-κB signalling in patients with a relapsing-remitting disease course, but thus far there is little information on whether it is also dysregulated in patients with progressive disease. We hypothesised that patients with progressive MS would have more activation of NF-κB than relapsing-remitting MS patients. Using several different methods, we showed that there was more nuclear translocation of p65 in cells from progressive MS patients, particularly in T cells and monocytes...
April 6, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29661539/mir-548k-regulates-cxcl13-expression-in-myasthenia-gravis-patients-with-thymic-hyperplasia-and-in-jurkat-cells
#9
Jinpin Li, Di Qiu, Zezhi Chen, Weiwei Du, Jingli Liu, Xuean Mo
Myasthenia gravis (MG) is a B cell-mediated and T cell-dependent autoimmune disease. Thymic hyperplasia has great significance for MG pathogenesis and treatment. MicroRNAs (miRNAs) are a newly recognized type of gene expression regulatory factor that regulate gene expression at the post-transcriptional level. Additionally, miRNAs are involved in immune regulation of the thymus and the occurrence and development of autoimmune diseases. In this study, we found 33 miRNAs that were significantly dysregulated in thymic tissues from MG patients with thymus hyperplasia (MGH) compared with thymic tissues from normal controls using a miRNA microarray chip...
April 4, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29628174/early-identification-of-anti-nmda-receptor-encephalitis-presenting-cerebral-lesions-in-unconventional-locations-on-magnetic-resonance-imaging
#10
Weihe Zhang, Lei Cui, Wei Wang, Yujuan Jiao, Yeqiong Zhang, Jinsong Jiao
To facilitate the diagnosis of anti-NMDAR encephalitis presenting with brain lesions in unconventional locations (BLUL) on MRI, we retrospectively analyzed forty-five Chinese patients. Eighteen (40.0%) of their MRI initially exhibited one or more BLUL. These locations predominantly included cerebral gray matter (cortex, basal ganglia and thalamus), as well as white matter and brainstem. Due to these BLUL, thirteen (72.2%) patients were originally misdiagnosed with other diseases and developed poor clinical and imaging outcomes...
March 29, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29576322/evidence-for-association-of-stat4-and-il12rb2-variants-with-myasthenia-gravis-susceptibility-what-is-the-effect-on-gene-expression-in-thymus
#11
Zoi Zagoriti, George Lagoumintzis, Gianluca Perroni, George Papathanasiou, Andreas Papadakis, Vincenzo Ambrogi, Tommaso Claudio Mineo, John S Tzartos, Konstantinos Poulas
Myasthenia gravis (MG) is an autoimmune disease mediated by the presence of autoantibodies that bind mainly to the acetylcholine receptor (AChR) in the neuromuscular junction. In our case-control association study, we analyzed common variants located in genes of the IL12/STAT4 and IL10/STAT3 signaling pathways. A total of 175 sporadic MG patients of Greek descent, positively detected with anti-AChR autoantibodies and 84 ethnically-matched, healthy volunteers were enrolled in the study. Thymus samples were obtained from 16 non-MG individuals for relative gene expression analysis...
March 17, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29573847/granulocyte-macrophage-colony-stimulating-factor-neuroprotective-activities-in-alzheimer-s-disease-mice
#12
Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Izumi Yokoyama, R Lee Mosley, Howard E Gendelman
We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. These data extend GM-CSF pleiotropic neuroprotection mechanisms in AD and include regulatory T cell-mediated immunomodulation of microglial function, Aβ clearance, maintenance of synaptic integrity, and induction of neurogenesis...
March 17, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29572032/chloride-imbalance-is-involved-in-the-pathogenesis-of-optic-neuritis-in-neuromyelitis-optica
#13
Tetsuya Akaishi, Toshiyuki Takahashi, Noriko Himori, Takayuki Takeshita, Toru Nakazawa, Masashi Aoki, Ichiro Nakashima
Chloride imbalance between the serum and the cerebrospinal fluid (CSF) has been recently shown to exist in the acute phase of neuromyelitis optica (NMO). In this report, we studied the relation between the quotient of chloride (QCl ) and the severity of optic neuritis (ON) in NMO patients. There was a positive correlation (R = 0.67; p < 0.05) between QCl and the length of ON-lesion. The visual prognosis also showed a positive correlation with QCl in the acute phase (R = 0.58; p < 0.05)...
March 16, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29566973/immunology-of-oligodendrocyte-precursor-cells-in-vivo-and-in-vitro
#14
Jack P Antel, Yun Hsuan Lin, Qiao-Ling Cui, Florian Pernin, Timothy E Kennedy, Samuel K Ludwin, Luke M Healy
Remyelination following myelin/oligodendrocyte injury in the central nervous system (CNS) is dependent on oligodendrocyte progenitor cells (OPCs) migrating into lesion sites, differentiating into myelinating oligodendrocytes (OLs), and ensheathing axons. Experimental models indicate that robust OPC-dependent remyelination can occur in the CNS; in contrast, histologic and imaging studies of lesions in the human disease multiple sclerosis (MS) indicate the variable extent of this response, which is particularly limited in more chronic MS lesions...
March 13, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29576323/immunomodulatory-treatment-with-systemic-gm-csf-augments-pulmonary-immune-responses-and-improves-neurological-outcome-after-experimental-stroke
#15
Claudia Dames, Katarzyna Winek, Yasmin Beckers, Odilo Engel, Andreas Meisel, Christian Meisel
Stroke-induced immunodepression is an independent risk factor for stroke-associated pneumonia (SAP). Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. However, whether GM-CSF restores immune function after stroke preventing SAP and improving outcome is unknown. Here, we demonstrated that GM-CSF treatment improved peripheral and pulmonary leukocyte numbers, peripheral cytokine responses, lowered lung bacterial burden in the early course and improved long-term functional outcome after experimental stroke...
March 9, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29580714/controllable-and-uncontrollable-stress-differentially-impact-pathogenicity-and-survival-in-a-mouse-model-of-viral-encephalitis
#16
Richard P Ciavarra, Mayumi Machida, Patric S Lundberg, Phillip Gauronskas, Laurie L Wellman, Christina Steel, Justin O Aflatooni, Larry D Sanford
Intranasal instillation of vesicular stomatitis virus (VSV) into mice given controllable stress (modeled by escapable foot shock, ES) resulted in enhanced pathogenicity and decreased survival relative to infected mice given uncontrollable stress (modeled by inescapable foot shock, IS) and non-shocked control mice. Survival likely reflected differential cytokine gene expression that may have been regulated by miR146a, a predicted stress-responsive upstream regulator. Controllability also enhanced the accumulation of brain T resident memory cells that persisted long after viral clearance...
March 8, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29759145/thymoquinone-increases-the-expression-of-neuroprotective-proteins-while-decreasing-the-expression-of-pro-inflammatory-cytokines-and-the-gene-expression-nf%C3%AE%C2%BAb-pathway-signaling-targets-in-lps-ifn%C3%AE-activated-bv-2-microglia-cells
#17
Makini K Cobourne-Duval, Equar Taka, Patricia Mendonca, Karam F A Soliman
Neuroinflammation and microglial activation are pathological markers of a number of central nervous system (CNS) diseases. Chronic activation of microglia induces the release of excessive amounts of reactive oxygen species (ROS) and pro-inflammatory cytokines. Additionally, chronic microglial activation has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Thymoquinone (TQ) has been identified as one of the major active components of the natural product Nigella sativa seed oil...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29759144/tropisetron-attenuates-lipopolysaccharide-induced-neuroinflammation-by-inhibiting-nf-%C3%AE%C2%BAb-and-sp-nk1r-signaling-pathway
#18
Yan Yu, Wanhu Zhu, Qing Liang, Jing Liu, Xu Yang, Guangchun Sun
Tropisetron, an antagonist of serotonin type 3 receptors (5-HT3 Rs), has been investigated in colonic inflammatory process. Since substance P/neurokinin 1 receptor (SP/NK1R) signaling pathway plays a key role in several sensory neuronal inflammatory. We evaluated the anti-inflammatory activity of tropisetron in mice cerebral cortex, and discovered that it was a potential inhibitor in LPS-mediated neuron inflammation through SP/NK1R signaling pathway. We found that tropisetron significantly reduced the increased number of iba-1 positive microglia, down-regulated the gene transcription and protein expression of IL-1β,IL-6 and TNF-α in LPS stimulated cerebral cortex...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29759143/niacin-modulates-macrophage-polarization-in-parkinson-s-disease
#19
Chandramohan Wakade, Banabihari Giri, Aneeq Malik, Hesam Khodadadi, John C Morgan, Raymond K Chong, Babak Baban
Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29759142/heterogeneity-of-auto-antibodies-against-nachr-in-myasthenic-serum-and-their-pathogenic-roles-in-experimental-autoimmune-myasthenia-gravis
#20
Ryuichi Nakamura, Tomohiro Makino, Takeshi Hanada, Maki Terakawa, Kazuhiro Nagahira, Jyoji Yamate, Hirokazu Shiraishi, Masakatsu Motomura
Many myasthenia gravis (MG) patients have auto-antibodies against the nicotinic acetylcholine receptor (nAChR), and monoclonal antibodies against the main immunogenic region (MIR) of nAChR can induce experimental autoimmune MG (EAMG). We investigated whether Fab fragment of MIR antibody (Fab35) could block the pathogenicity of polyclonal antibodies. Fab35 partially inhibited nAChR downmodulation, blocked EAMG serum-induced binding of polyclonal antibodies and complement deposition in vitro. Moreover, Fab35 did not ameliorate the EAMG serum-induced EAMG phenotype in rats...
July 15, 2018: Journal of Neuroimmunology
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