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Journal of Neuroimmunology

Fazilet Dede, Sabriye Karadenizli, Ozgur Doga Ozsoy, Fatma Ceyla Eraldemir, Deniz Sahin, Nurbay Ates
Epilepsy is a major pathological condition, characterized by recurrent seizures and affecting approximately 1% of the population. Many studies have shown a relationship between epilepsy and inflammation. The adenosinergic system contributes to inflammation and epilepsy by regulating the release of neurotransmitters through its various receptors. This study investigates the effect of agonist and antagonist of adenosinergic system on seizure activity and cytokine levels in the WAG/Rij strain, a genetic animal model of absence epilepsy...
November 7, 2018: Journal of Neuroimmunology
Ju Liu, Qin Zhang, Ziyan Shi, Mu Yang, Zhiyun Lian, Hongxi Chen, Huiru Feng, Qin Du, Ying Zhang, Xiaohui Miao, Huifang Li, Hongyu Zhou
Currently, no data are available regarding the expression levels of CD40L on CD4+ T cells in patients with neuromyelitis optica spectrum disorders (NMOSD). The percentage of circulating CD40L+ CD4+ T cells was measured by flow cytometry in 23 NMOSD patients and 10 healthy controls. The ratio of CD40L+ CD4+ to CD4+ T cells in patients at acute phase (18.28 ± 15.56%) was significantly higher than that in healthy controls (7.23 ± 5.94%, P = .032) and was positively correlated with disease severity (r = 0...
November 1, 2018: Journal of Neuroimmunology
Giuseppe A Ramirez, Lavinia A Coletto, Enrica P Bozzolo, Lorena Citterio, Simona Delli Carpini, Laura Zagato, Patrizia Rovere-Querini, Chiara Lanzani, Paolo Manunta, Angelo A Manfredi, Clara Sciorati
Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner...
October 23, 2018: Journal of Neuroimmunology
I Cavazzana, A Alberici, E Bonomi, R Ottaviani, R Kumar, S Archetti, M Manes, M Cosseddu, E Buratti, A Padovani, A Tincani, F Franceschini, B Borroni
Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p < .001). In FTD, ANA-positive and ANA-negative patients did not differ for any clinical feature. These data extend and further confirm autoimmune dysregulation in FTD...
October 19, 2018: Journal of Neuroimmunology
Kirat Singh Grewal, Rohit Bhatia, Nishita Singh, Rajesh Singh, Deepa Dash, Manjari Tripathi
We report the case of a pregnant female presenting with behavioral change and hallucinations followed by focal seizures with impaired awareness. EEG revealed generalized slowing interspersed with extreme delta-brush pattern and MRI brain was normal. Both Serum and CSF anti-N-methyl-d-aspartate receptor (NMDAR) antibodies were positive. Patient had a prolonged hospital stay with full recovery and delivered a healthy baby, highlighting the significance of early diagnosis and management in this disorder.
October 19, 2018: Journal of Neuroimmunology
Banafsheh Safizadeh, Reyhane Hoshyar, Masoud Mehrpour, Mehrdad Eftekhar, Vahid Salimi, Shaghayegh Yazdani, Bita Bijari, Farshad Khodakhah, Masoumeh Tavakoli-Yaraki
BACKGROUND: Multiple Sclerosis (MS) as an inflammatory multifactorial auto immune nervous system disease imposes devastating burden of morbidity worldwide. Among environmental and genetic factors, the relevance of inflammatory mediators in MS pathogenesis is well documented. 15-Lipoxygense enzyme and its derived products have received attention as possible mediators of inflammatory responses. The involvement of 15-Lipoxygense pathway in the pathogenesis of inflammatory diseases such as MS has yet to be illustrated which is perused in the current study...
October 18, 2018: Journal of Neuroimmunology
Saba I Aqel, Marissa C Granitto, Patrick K Nuro-Gyina, Wei Pei, Yue Liu, Amy E Lovett-Racke, Michael K Racke, Yuhong Yang
B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE...
October 15, 2018: Journal of Neuroimmunology
Mohammed Alrouji, Ali Manouchehrinia, Bruno Gran, Cris S Constantinescu
Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of inflammatory responses with a parallel reduction of some immune defences, resulting in an increased susceptibility to infection and a persistent proinflammatory environment. We discuss the effect of smoking on the susceptibility, clinical course, disability, and mortality in MS, the likely benefits of smoking cessation, and the specific immunological effects of smoking in MS...
October 9, 2018: Journal of Neuroimmunology
Edson Fernando Müller Guzzo, Karina Rodrigues Lima, Carmen Regla Vargas, Adriana Simon Coitinho
The objective of this study was to evaluate the effect of dexamethasone, on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by pentylenetetrazole (20 mg/kg) in alternated days for 15 days of treatment. The animals were divided into five groups: control group given saline, a group treated with diazepam (2 mg/kg) and groups treated with dexamethasone (1, 2 and 4 mg/kg). Open field test was conducted. The treatment with dexamethasone decreased the severity of seizures, also decreased TNF-alpha and Interleukin 1 beta levels in the hippocampus and TNF-alpha level in the serum...
October 7, 2018: Journal of Neuroimmunology
Liis Sabre, Jeffrey T Guptill, Melissa Russo, Vern C Juel, Janice M Massey, James F Howard, Lisa D Hobson-Webb, Anna Rostedt Punga
Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4...
October 6, 2018: Journal of Neuroimmunology
Monika Sharma, Patrick M Flood
Microglial activation contributes to chronic inflammation and neuronal loss in progressive neurodegenerative disorders such as Parkinson's disease (PD). Thus, treatments suppressing microglial activation may have therapeutic benefits to prevent neuronal loss in neurodegenerative diseases. Our previous findings show that Salmeterol, a long-acting β2-adrenergic receptor (β2-AR) agonist, is neuroprotective in two distinct animal models of PD, including where lipopolysaccharide (LPS) from E. coli was used to initiate chronic neurodegeneration...
October 4, 2018: Journal of Neuroimmunology
Vahid Tavakolpour, Gelareh Shokri, Abdorreza Naser Moghadasi, Parisa Mozafari Nahavandi, Mehrdad Hashemi, Fatemeh Kouhkan
Most of the multiple sclerosis (MS) patients are initially diagnosed with relapsing remitting multiple sclerosis (RRMS). Th17 cells and macrophages have been shown to play critical roles in pathogenesis of MS and initiation of CNS tissue damage. MiR-301a have recently been exposed as an activator of STAT3 in Th17 cells as well as an activator of NF-κB in macrophages by targeting PIAS3 and NKRF correspondingly. However, the possible role of miR-301a in RRMS has not yet been elucidated. Herewith, for the first time, we have studied the expression of miR-301a, NKRF and PIAS3 by quantitative real-time PCR and western blotting method in peripheral blood mononuclear cells (PBMCs) of 71 RRMS patients, including two groups of patients in relapse phase (n = 44) and a group of remitting phase patients (n = 28) in comparison to healthy volunteers (n = 28)...
October 4, 2018: Journal of Neuroimmunology
Kazuo Sugimoto, Takaki Hiwasa, Kazutomo Shibuya, Shigeki Hirano, Minako Beppu, Sagiri Isose, Kimihito Arai, Masaki Takiguchi, Satoshi Kuwabara, Masahiro Mori
OBJECTIVE: To identify autoantibodies using sera from ALS patients and elucidate their roles in disease pathology. METHODS: An immunological screening was performed with a phage expression library SEREX method using sera from 3 ALS patients to identify ALS-related autoantibodies. Levels of antibodies identified by SEREX were measured in 33 ALS patients and 30 normal controls (NCs) by AlphaLISA using recombinant non-full-length proteins. The results were then validated by ELISA using full-length proteins in 71 ALS patients, 30 NCs and 34 disease controls (DCs)...
October 1, 2018: Journal of Neuroimmunology
Anjiao Peng, Masako Kinoshita, Wanlin Lai, Arui Tan, Xiangmiao Qiu, Lin Zhang, Wanling Li, Lei Chen
This meta-analysis aimed to systematically review current literature measuring the thickness of retinal nerve fiber layer (RNFL) in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated optic neuritis. Ten studies were enrolled and the results showed that the degree of RNFL loss in MOG-ab-positive optic neuritis patients may not differ from that of AQP4-ab patients. However, patients who were positive for MOG-ab showed more severe RNFL loss than those who were seronegative.
September 27, 2018: Journal of Neuroimmunology
Kazuo Iwasa, Hiroaki Yoshikawa, Yutaka Furukawa, Masahito Yamada
We investigated the expression patterns of programmed cell death-ligand 1 (PD-L1) in the skeletal muscle of 15 patients with myasthenia gravis (MG). In 11 of the patients, immunohistochemistry confirmed the localization of PD-L1 in the muscle cell membrane with cytoplasmic integrity. PD-L1 mRNA expression levels were higher in the muscles of MG patients as compared to those of non-myogenic patients (p < .05). Moreover, a unimodal relationship between PD-L1 mRNA levels and quantitative MG scores for disease severity was identified by a generalized additive model, indicating reciprocal effects...
September 27, 2018: Journal of Neuroimmunology
Valerio Castoldi, Silvia Marenna, Roberto Santangelo, Raffaele d'Isa, Marco Cursi, Linda Chaabane, Angelo Quattrini, Giancarlo Comi, Letizia Leocani
Dark-Agouti rats were immunized with spinal cord homogenate to develop Experimental Autoimmune Encephalomyelitis, a model of multiple sclerosis. We assessed motor signs and recorded VEPs for five or eight weeks with epidural or epidermal electrodes, respectively, with final histopathology of optic nerves (ONs). Injected rats exhibited motor deficits a week after immunization. VEP delays arose from the 2nd to the 5th week, when a recovery occurred in epidermal-recorded rats. ON damage appeared in epidural-, but not in epidermal-recorded rats, probably due to a remyelination process...
September 25, 2018: Journal of Neuroimmunology
Sanna Hagman, Aliisa Mäkinen, Laura Ylä-Outinen, Heini Huhtala, Irina Elovaara, Susanna Narkilahti
Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease, where neural progenitor cell (NPC) transplantation has been suggested as a potential neuroprotective therapeutic strategy. Since the effect of inflammation on NPCs is poorly known, their effect on the survival and functionality of human NPCs were studied. Treatment with interleukin (IL)-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ did not induced cytotoxicity, but IFN-γ treatment showed decreased proliferation and neuronal migration...
August 29, 2018: Journal of Neuroimmunology
Viviana Annibali, Renato Umeton, Antonia Palermo, Martina Severa, Marilena Paola Etna, Simona Giglio, Silvia Romano, Michela Ferraldeschi, Maria Chiara Buscarinu, Andrea Vecchione, Anita Annese, Claudia Policano, Rosella Mechelli, Raffaella Pizzolato Umeton, Arianna Fornasiero, Daniela Francesca Angelini, Gisella Guerrera, Luca Battistini, Eliana Marina Coccia, Marco Salvetti, Giovanni Ristori
Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1-IRF1, and C-X-C motif chemokine 10-CXCL10), belonging to the same pathway, was validated by RT-PCR in 26 patients and 21 controls. IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients...
November 15, 2018: Journal of Neuroimmunology
Kullasate Sakpichaisakul, Lucksanai Patibat, Thanin Wechapinan, Somjit Sri-Udomkajrorn, Metha Apiwattanakul, Sirorat Suwannachote
Recommended first line treatment in anti-NMDAR encephalitis includes steroids, IVIG, or plasma exchange. However, IVIG is non-reimbursable through Thailand's Universal Health Coverage. This study investigated outcomes from different treatments for anti-NMDAR encephalitis. Nineteen children in three treatments group: steroid alone, IVIG alone, and IVIG and steroid were reviewed. IVIG was administered to 13 (68%) and 6 (32%) only received steroids. Those receiving IVIG treatment with or without steroids had greater improvement in mRS at 6 (p = 0...
November 15, 2018: Journal of Neuroimmunology
Itay Lotan, Mark A Hellmann, Felix Benninger, Hadas Stiebel-Kalish, Israel Steiner
BACKGROUND: Optic neuritis is a frequent finding in multiple sclerosis (MS) and in neuromyelitis optica spectrum disorder (NMOSD), as well as in Myelin-Oligodendrocyte Glycoprotein (MOG) -positive disease. While both NMOSD and MOG-antibody disease are known to be associated with a humoral, antibody-mediated attack against a specific antigen, much less is known about the etiology and pathogenesis of MS. The aim of this study was to determine if the localization of recurrent episodes of ON follows the same pattern in MS as in NMOSD and in MOG-positive recurrent ON...
November 15, 2018: Journal of Neuroimmunology
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