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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/29215386/improving-the-clinical-pharmacologic-assessment-of-abuse-potential-part-1-regulatory-context-and-risk-management
#1
Edward M Sellers
PURPOSE: This article brings to the attention of drug developers the Food and Drug Administration's (FDA's) recent final Guidance to Industry on Assessment of Abuse Potential and provides practical suggestions about compliance with the Guidance. PROCEDURES: The Guidance areas are reviewed, analyzed, and placed in the context of current scientific knowledge and best practices to mitigate regulatory risk. FINDINGS: The Guidance provides substantial new detail on what needs to be done at all stages of drug development for central nervous system-active drugs...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29215385/restless-legs-syndrome-and-schizophrenia-a-case-report
#2
Romain Colle, Flavien Boichot, Erwan Bouteiller, Céline Elie-Lefebvre, Patrick Hardy, Denis J David, Céline Verstuyft, Emmanuelle Corruble
No abstract text is available yet for this article.
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29215384/update-on-psychotropic-drug-prescribing-in-the-united-states-2014-2015
#3
David J Greenblatt, Jerold S Harmatz, Richard I Shader
No abstract text is available yet for this article.
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29215383/mood-stabilizing-anticonvulsants-spina-bifida-and-folate-supplementation-commentary
#4
Neil Patel, Adele C Viguera, Ross J Baldessarini
PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29200012/a-naturalistic-evaluation-of-change-in-antidepressant-prescription-in-patients-with-affective-and-anxiety-disorders-in-a-tertiary-care-hospital-of-india
#5
Amol Patil, Swapnajeet Sahoo, Gaurav Garg, Sandeep Grover
BACKGROUND: Although many studies have evaluated prescription patterns, there is lack of information on the choice of antidepressants among patients who do not respond antidepressants. Similarly, information on switching strategies is also limited. This naturalistic study aimed to evaluate the switching strategies and preferred antidepressants by the psychiatrists among patients who do not respond to or who are not able to tolerate an antidepressant. METHODS: A cross-sectional observational study design was followed...
December 1, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29194089/quetiapine-dose-adjustments-in-pregnant-and-postpartum-women-with-bipolar-disorder
#6
Emily A Pinheiro, Katherine L Wisner, Crystal T Clark
No abstract text is available yet for this article.
December 1, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210866/abrupt-improvement-in-obsessive-compulsive-symptoms-upon-discontinuation-of-clozapine
#7
Lindsay-Rose Dykema
No abstract text is available yet for this article.
November 29, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210865/severe-serotonin-syndrome-in-an-autistic-new-psychoactive-substance-user-after-consumption-of-pills-containing-methoxphenidine-and-%C3%AE-methyltryptamine
#8
Basile Chrétien, Joanna Bourgine, Léa Hamel Sénécal, Marie Bretaudeau-Deguigne, Davis Boels, Véronique Lelong-Boulouard, Reynald Le Boisselier
No abstract text is available yet for this article.
November 29, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210869/treatment-of-behavioral-disinhibition-in-huntington-s-disease-with-valproic-acid
#9
William L Whiting, Regina Velasco, Jonathan T Stewart
No abstract text is available yet for this article.
November 28, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210868/is-there-a-potential-of-misuse-for-quetiapine-literature-review-and-analysis-of-the-european-medicines-agency-european-medicines-agency-adverse-drug-reactions-database
#10
Stefania Chiappini, Fabrizio Schifano
PURPOSE/BACKGROUND: A recent years' increase in both prescribing and availability of second-generation antipsychotics (SGAs) has been observed. According to the literature, typically made up by case studies/series, quetiapine seems to be the most commonly misused SGA, with both intranasal and intravenous intake modalities having been described. Another SGA that has been anecdotally reported to be misused is olanzapine. For these molecules, both a previous history of drug misuse and being an inmate have been described as factors associated with misuse...
November 28, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210867/antipsychotic-polypharmacy-and-its-relation-to-metabolic-syndrome-in-patients-with-schizophrenia-an-egyptian-study
#11
Dina M Aly El-Gabry, Karim Abdel Aziz, Tarek Okasha, Hanan Azzam, Ahmed Okasha
PURPOSE/BACKGROUND: Few studies have examined the relationship between antipsychotic polypharmacy and metabolic syndrome in schizophrenia. Some studies suggest that antipsychotic polypharmacy may be associated with greater metabolic risk, whereas other studies suggest that this is uncertain. To date, there have been no studies in Egypt or the Arab world that have investigated this relationship. We sought to compare subjects with schizophrenia receiving antipsychotic polypharmacy and monotherapy as regards metabolic outcomes and to investigate medication-related factors associated with metabolic syndrome...
November 28, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210808/prophylactic-use-of-haloperidol-and-changes-in-glucose-levels-in-hospitalized-older-patients
#12
Kris van Keulen, Wilma Knol, Edmée J M Schrijver, Rob J van Marum, Astrid M van Strien, Prabath W B Nanayakkara
BACKGROUND: Treatment with antipsychotic drugs has been associated with glucose dysregulation in older outpatients, especially in the early stage of therapy. The underlying mechanism is, however, unclear. The aim of this study was to investigate changes in glucose levels during haloperidol use compared with the use of placebo among older hospitalized patients. METHODS: This substudy was part of a larger multicenter, randomized, double blind, placebo-controlled clinical trial among hospitalized patients aged 70 years and older who had an increased risk of in-hospital delirium...
November 27, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29176500/a-pilot-study-of-a-topical-intervention-for-treatment-of-female-sexual-dysfunction
#13
Adel Abdel-Wadood Gomaa, Nermeen M Abdel Aziz, Romany H Thabet, Howieda A Fouly, Sara H Altellawy, Ghada A Gomaa
PURPOSE/BACKGROUND: Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with different mechanisms of action in treating FSD. METHODS: In this randomized, controlled pilot trial, premenopausal (n = 30) and postmenopausal (n = 30) cases of 21- to 62-year age range with FSD were allocated randomly into 15 given placebo or 15 given active cream in each group...
November 22, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29189409/serotonin-and-love-supporting-evidence-from-a-patient-suffering-from-obsessive-compulsive-disorder
#14
Donatella Marazziti, Stephen M Stahl
No abstract text is available yet for this article.
November 20, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29189408/monoamine-oxidase-inhibitor-switching-strategiesno-adverse-events-associated-with-outpatient-cross-taper-or-inpatient-rapid-switch
#15
John F Polnak, Amber Finegan, Hyun Ji, Ericka L Crouse, Adam Rosenblatt, Michael Weitzner, Kristen N Gardner
No abstract text is available yet for this article.
November 20, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045307/prevalence-of-antipsychotic-treated-patients-in-a-cohort-of-adult-addicted-patients
#16
Hélène Peyrière, Caroline Diot, Erika Nogue, Marie Verschave, Morgan Laure, Marie-Christine Picot, Pierre Petit, Hélène Donnadieu-Rigole, Yves Leglise
PURPOSE: The objective of this cross-sectional study was to describe and estimate the prevalence of antipsychotics (AP) in a cohort of addicted patients, and to compare the profiles of addictive patients receiving AP or not. METHODS: We included all adult patients seen at the addiction care center of Montpellier University Hospital, between January 1, 2015, and March 31, 2015. Demographic, clinical, and therapeutic data were collected from the patients' medical records...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045304/effect-of-clozapine-vs-other-second-generation-antipsychotics-on-hospitalization-and-seclusion-a-retrospective-mirror-image-study-in-a-japanese-public-psychiatric-hospital
#17
Fuminari Misawa, Takefumi Suzuki, Yasuo Fujii
BACKGROUND: Clozapine has been regarded as the gold standard for patients with treatment-resistant schizophrenia, but a recent network meta-analysis has questioned its relative superiority over other second-generation antipsychotics (SGAs) such as olanzapine and risperidone. PURPOSE: We conducted a retrospective mirror-image study of clozapine vs other SGAs to evaluate real-world effectiveness of clozapine in terms of the duration of hospitalization and seclusion, both of which represent a critical outcome...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045301/cannabinoid-hyperemesis-syndrome-chs-a-parisian-case-series
#18
Maude Marillier, Anne Batisse, Yves Edel, An-Hung Nguyen, Cécile Chevallier, Grégory Pfau, Philippe Podevin, Samira Djezzar
No abstract text is available yet for this article.
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29040153/vortioxetine-and-aripiprazole-combination-in-treatment-resistant-obsessive-compulsive-disorder-a-case-report
#19
Domenico De Berardis, Luigi Olivieri, Francesco Nappi, Gabriella Rapini, Federica Vellante, Ilaria Matarazzo, Nicola Serroni, Massimo Di Giannantonio
No abstract text is available yet for this article.
October 16, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29040152/acute-laryngeal-dystonia-associated-with-asenapine-use-a-case-report
#20
Nathaniel Collins, Jeffrey Sager
No abstract text is available yet for this article.
October 16, 2017: Journal of Clinical Psychopharmacology
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