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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/29621092/a-case-of-drug-dependence-syndrome-to-baclofen-following-high-dose-therapy
#1
Léa Hamel Sénécal, Basile Chrétien, Pierre-Yves Jean-Jacques, Véronique Lelong Boulouard, Daniel Cohen, Reynald Le Boisselier
No abstract text is available yet for this article.
April 4, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29621091/severe-cognitive-impairment-associated-with-a-high-free-but-therapeutic-total-concentration-of-valproic-acid-due-to-hypoalbuminemia-in-an-older-patient-with-bipolar-disorder
#2
Géraud Dautzenberg, Mariëtte Nederlof, Aartjan Beekman, Toine Egberts, Eibert R Heerdink
No abstract text is available yet for this article.
April 4, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620701/pharmacokinetics-of-sustained-release-oral-dexamphetamine-sulfate-in-cocaine-and-heroin-dependent-patients
#3
Maikel Herbrink, Masha Nuijten, Bastiaan Nuijen, Alwin D R Huitema, Jos H Beijnen, Vincent M Hendriks, Peter Blanken, Amin Janmohamed, Wim van den Brink
INTRODUCTION: Research has shown that sustained-release (SR) dexamphetamine is a promising agonist treatment for cocaine dependence. However, little is known about the pharmacokinetics (PKs) of SR oral dexamphetamine. This study examined the PKs of a new SR dexamphetamine formulation in cocaine plus heroin-dependent patients currently in heroin-assisted treatment. METHODS: The study was designed as an open-label PK study in 2 cohorts: n = 5 with once daily 60 mg and n = 7 with once daily 30 mg SR oral dexamphetamine...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620700/doxepin-misuse-and-abuse
#4
Benjamin Spurling, Leah Clark, Adam J Fusick, William L Whiting
No abstract text is available yet for this article.
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620699/comedication-of-valproic-acid-is-associated-with-increased-metabolism-of-clozapine
#5
Leif Hommers, Magdalena Scharl, Gudrun Hefner, Matthias Hohner, Matthias Fischer, Bruno Pfuhlmann, Jürgen Deckert, Stefan Unterecker
OBJECTIVES: Valproic acid and clozapine are drugs commonly used in the treatment of schizophrenic and schizoaffective disorders. Pharmacokinetic interactions of valproic acid with several drugs are well known, yet results concerning the interaction with clozapine are inconsistent. METHODS: Steady-state dose-corrected serum concentrations of clozapine and its main metabolite norclozapine were retrospectively analyzed in 45 patients receiving both clozapine and valproic acid...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620698/complex-polypharmacy-in-patients-with-schizophrenia-spectrum-disorders-before-a-psychiatric-hospitalization-prescribing-patterns-and-associated-clinical-features
#6
Brandon A Gaudiano, Carolina Guzman Holst, Alexandra Morena, Lauren E Reeves, Valerie J Sydnor, Gary Epstein-Lubow, Lauren M Weinstock
BACKGROUND: Current evidence-based guidelines provide unclear support for many common polypharmacy practices in schizophrenia. Excessive or complex polypharmacy (≥4 psychotropics) has been studied in patients with bipolar disorder, but not in schizophrenia to date. METHODS: We conducted a digital medical record data extraction of 829 patients consecutively admitted to a psychiatric hospital and diagnosed as having schizophrenia-spectrum disorders. RESULTS: In those prescribed psychiatric medication preadmission, 28...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620697/iatrogenic-engorgement-of-the-clitoris-due-to-antidepressants-report-of-a-case
#7
Francesco Raudino, Grazia Buono
No abstract text is available yet for this article.
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620696/mephenesin-is-there-a-progression-in-cases-of-substance-use-related-disorders-in-france
#8
Cecile Chevallier, Anne Batisse, Maeva Fortias, Samira Djezzar
No abstract text is available yet for this article.
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620695/misuse-of-trihexyphenidyl-artane-on-r%C3%A3-union-island
#9
Romain Torrents, Jean Francois Ferré, Annie Konareff, Patrice Hemery, Kenneth Sherwin, Christian Lassalle, Nicolas Simon, Sami Scerra
BACKGROUND: Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis. The aim of this cohort was to show and describe, within a public health risk management policy, the risks of a long-standing but relatively unknown addiction: THP addiction. METHODS: On Réunion island, a cohort with systematic data collection has been set up by addictologists working in the Centres for Addiction Prevention and Treatment, in the university hospital, and in general practices who have active lists of patients misusing THP...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620694/genetic-polymorphisms-associated-with-constipation-and-anticholinergic-symptoms-in-patients-receiving-clozapine
#10
Anssi Solismaa, Olli Kampman, Leo-Pekka Lyytikäinen, Niko Seppälä, Merja Viikki, Nina Mononen, Terho Lehtimäki, Esa Leinonen
BACKGROUND: Clozapine impairs gastrointestinal motility owing to its anticholinergic and antiserotonergic properties. This commonly leads to constipation and potentially to more severe complications such as bowel obstruction and ischemia. The aim of this study was to determine whether genetic variations in the genes encoding muscarinic and serotonergic receptors (CHRM2, CHRM3, HTR2, HTR3, HTR4, and HTR7) explain the variations in incidence of constipation and anticholinergic symptoms during clozapine treatment...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620693/longer-term-effectiveness-and-tolerability-of-adjunctive-open-lurasidone-in-patients-with-bipolar-disorder
#11
Shefali Miller, Dennis Do, Anda Gershon, Po W Wang, Farnaz Hooshmand, Lauren S Chang, Terence A Ketter
PURPOSE: To retrospectively assess lurasidone effectiveness/efficacy/tolerability in bipolar disorder (BD) patients. METHODS: Outpatients assessed with Systematic Treatment Enhancement Program for BD Affective Disorders Evaluation received naturalistically administered (primarily adjunctive) open lurasidone while monitored at visits with the Systematic Treatment Enhancement Program for BD Clinical Monitoring Form. RESULTS: Sixty-one patients (32 type I, 26 type II, 3 type not otherwise specified; mean ± SD age, 45...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620692/efficacy-and-safety-of-agomelatine-vs-paroxetine-hydrochloride-in-chinese-han-patients-with-major-depressive-disorder-a-multicentre-double-blind-noninferiority-randomized-controlled-trial
#12
Yi-Min Yu, Ke-Run Gao, Hao Yu, Yi-Feng Shen, Hua-Fang Li
PURPOSE: The purpose of this study is to investigate the efficacy, safety, and tolerability of agomelatine and paroxetine in Chinese Han patients with major depressive disorder (MDD). METHODS: A 8-week, double-blind, randomized, parallel study was conducted in 14 medical centers in mainland China from December 2011 to September 2012. A total of 264 subjects with a primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of MDD were randomly assigned to receive agomelatine 25-50 mg/d (n = 132) or paroxetine 20-40 mg/d (n = 132)...
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620691/do-antipsychotics-thin-the-brain-it-is-a-rather-gray-matter
#13
Ronald W Pies
No abstract text is available yet for this article.
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29620690/angioedema-caused-by-rivastigmine-patch-a-rare-case
#14
Mehmet Ilkin Naharci, Ilker Tasci
No abstract text is available yet for this article.
April 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29613865/rhabdomyolysis-of-multifactorial-origin-in-schizophrenia-antipsychotics-statins-trauma
#15
Carlota Botillo-Martin, Emilio González-Pablos
No abstract text is available yet for this article.
April 2, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29613864/systemic-inflammation-complicates-the-interpretation-of-therapeutic-drug-monitoring-of-risperidone
#16
Arne Helland, Simone Habib, Line Ulvestad, Olav Spigset
No abstract text is available yet for this article.
April 2, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29601319/long-term-near-infrared-photobiomodulation-for-anxious-depression-complicated-by-takotsubo-cardiomyopathy
#17
Marco Antonio Caldieraro, Gabriele Sani, Eric Bui, Paolo Cassano
No abstract text is available yet for this article.
March 29, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29601318/resolution-of-acute-onset-depersonalization-derealization-with-clonazepam-and-inpatient-hospitalization
#18
Jacob V Weber, William Frizzell, Kimberley A Bullard, Joseph Chien
No abstract text is available yet for this article.
March 29, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29601317/fatal-case-of-acute-cardiac-failure-after-long-term-physical-restraint-of-patient-treated-with-clozapine-in-psychiatric-ward
#19
Rafał Skowronek, Marcin Zawadzki, Jan Magdalan, Czesław Chowaniec
No abstract text is available yet for this article.
March 29, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29601316/clinical-trial-of-the-potassium-channel-activator-diazoxide-for-major-depressive-disorder-halted-due-to-intolerability
#20
Bashkim Kadriu, Shiwen Yuan, Cristan Farmer, Allison C Nugent, Marc S Lener, Mark J Niciu, Minkyung Park, Aaron Yazdian, Elizabeth D Ballard, Fritz A Henn, Ioline D Henter, Lawrence T Park, Carlos A Zarate
BACKGROUND: Some glutamatergic modulators have demonstrated rapid and relatively sustained antidepressant properties in patients with major depressive disorder. Because the potassium channel activator diazoxide increases glutamate uptake via potassium channel activation, we hypothesized that it might exert antidepressant effects by increasing the removal of glutamate from the synaptic cleft, thereby reducing excessive glutamate transmission. METHODS: This randomized, double-blind, placebo-controlled, crossover, single-site inpatient clinical study was conducted at the National Institute of Mental Health to assess the efficacy and safety of a 3-week course of diazoxide (200-400 mg daily, twice a day) versus a 3-week course of placebo in 6 participants with treatment-refractory major depressive disorder...
March 29, 2018: Journal of Clinical Psychopharmacology
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