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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/27846049/agomelatine-for-the-treatment-of-major-depressive-episodes-in-schizophrenia-spectrum-disorders-an-open-prospective-proof-of-concept-study
#1
Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Sarah Eisenacher, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Depressive episodes in schizophrenia constitute a major clinical problem, and treatment success is often limited by treatment-emergent side effects. Agomelatine, an agonist at melatonergic MT1/MT2 receptors and 5-HT2C receptor antagonist, is a new antidepressant with a novel mode of action which constitutes a potential therapeutic option for depression in schizophrenia. METHODS: Twenty-seven patients with lifetime diagnoses within the schizophrenia spectrum and comorbid depression were treated with agomelatine in addition to stable doses of antipsychotic agents...
October 29, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027115/memantine-plasma-concentrations-among-patients-with-dementia
#2
Irving H Gomolin, Michael J Papamichael, Melissa J Fazzari, Robert Rieger
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027114/5-ht1a-c-1019g-rs6295-predicts-aripiprazole-treatment-response-specifically-for-cognitive-and-depressive-symptoms-in-schizophrenia
#3
Shih-Fen Chen, Yu-Chih Shen
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027113/methotrimeprazine-associated-stevens-johnson-syndrome-in-2-ashkenazi-jewish-patients
#4
Dina Moubayed, Anthony J Gifuni, Leon Tourian
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027112/alcohol-triggers-reemergence-of-ketamine-like-experience-in-a-ketamine-ex-user
#5
Fong Chang, Ke Xu, Ming-Chyi Huang, John H Krystal
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027111/a-validation-study-of-the-international-consensus-diagnostic-criteria-for-neuroleptic-malignant-syndrome
#6
Ronald J Gurrera, Gino Mortillaro, Varadaraj Velamoor, Stanley N Caroff
BACKGROUND: Neuroleptic malignant syndrome requires prompt recognition for effective management, but there are no established diagnostic criteria. This is the first validation study of recently published international expert consensus (IEC) diagnostic criteria, which include priority points assigned on the basis of the importance of each criterion for making a diagnosis of neuroleptic malignant syndrome. METHODS: Data were extracted from 221 archived telephone contact reports of clinician-initiated calls to a national telephone consultation service from 1997 to 2009; each case was given a total priority point score on the basis of the IEC criteria...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027110/unaltered-dopamine-transporter-availability-in-drug-naive-patients-with-schizophrenia-after-6-months-of-antipsychotics-treatment-a-naturalistic-study
#7
Wei Hung Chang, Kao Chin Chen, I Hui Lee, Mei Hung Chi, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yang
BACKGROUND: Dopaminergic dysfunction, namely, dopamine transporter (DAT) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. The aims of the study were to explore (i) whether the DAT availability in patients with drug-naive schizophrenia differed after antipsychotic treatment and (ii) whether treatment with different generations of antipsychotics influenced the DAT availability after follow-up for 6 months. METHODS: Twenty-four first-episode, drug-naive patients with schizophrenia were divided into first- and second-generation antipsychotic groups naturalistically...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027109/the-relationship-between-early-haloperidol-response-and-associated-extrapyramidal-side-effects
#8
Sean A Rasmussen, Patricia I Rosebush, Michael F Mazurek
BACKGROUND: Early response to antipsychotic medication within 2 weeks of initiating treatment can predict psychiatric outcomes. However, it is unclear whether early response is also predictive of extrapyramidal side effects (EPSs) associated with antipsychotic medications. METHODS: In this study, we investigated 136 consecutive antipsychotic-naive, first-episode psychosis patients naturalistically treated with haloperidol. Patients were assessed at baseline and weekly after treatment initiation using the Brief Psychiatric Rating Scale, Hamilton Depression Rating Scale, and Hamilton Anxiety Rating Scale...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027108/some-reflections-on-meditation-and-mindfulness
#9
Richard I Shader, Susan Taylor
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28027107/meditation-and-mindfulness
#10
Richard I Shader
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28009752/exposure-to-anticholinergic-and-sedative-drugs-risk-of-falls-and-mortality-an-elderly-inpatient-multicenter-cohort-erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27984328/sex-differences-in-the-effect-of-atomoxetine-on-the-qt-interval-in-adult-patients-with-attention-deficit-hyperactivity-disorder
#12
Yutaro Suzuki, Misuzu Tajiri, Atsunori Sugimoto, Naoki Orime, Taketsugu Hayashi, Jun Egawa, Takuro Sugai, Yoshimasa Inoue, Toshiyuki Someya
BACKGROUND: The effects of atomoxetine on QT in adults remain unclear. In this study, we examined whether the use of atomoxetine to treat attention-deficit hyperactivity disorder in adults is associated with QT prolongation. METHODS: Forty-one subjects with attention-deficit hyperactivity disorder were enrolled in this study. Participants were administered 40, 80, or 120 mg atomoxetine daily and were maintained on their respective dose for at least 2 weeks. We conducted electrocardiographic measurements and blood tests, measuring plasma atomoxetine concentrations after treatment...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27977470/the-utility-of-low-dose-aripiprazole-for-the-treatment-of-bipolar-ii-and-bipolar-nos-depression
#13
Tammas Kelly, Daniel Z Lieberman
BACKGROUND: Despite initial reports of efficacy in bipolar depression, multicenter trials did not show aripiprazole to be better than placebo, possibly because the doses used were too high, leading to lower efficacy and high dropout rates. This study evaluated the effects of low-dose aripiprazole. Extensive clinical experience has suggested that doses beyond 5 mg are rarely efficacious. METHODS: Data were gathered from patients with bipolar II or bipolar not otherwise specified depression using a retrospective chart review...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27977469/efficacy-and-tolerability-of-high-dose-escitalopram-in-posttraumatic-stress-disorder
#14
Wei Qi, Martin Gevonden, Arieh Shalev
BACKGROUND: Open-label trials suggest that escitalopram (up to 20 mg/d) is an effective treatment for some, but not all posttraumatic stress disorder (PTSD) patients. Higher doses of escitalopram effectively reduced major depression symptoms in patients who had not responded to regular doses. The current study examines the efficacy, tolerability, and adherence to high-dose escitalopram in PTSD. METHODS: Forty-five PTSD patients received 12 weeks of gradually increasing doses of escitalopram reaching 40 mg daily at 4 weeks...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27977468/a-case-of-asperger-syndrome-with-comorbidity-of-posttraumatic-stress-disorder-and-selective-mutism-significant-remission-with-the-combination-of-aripiprazole-and-eye-movement-desensitization-and-reprocessing
#15
Melis Ipci, Sevim Berrin Inci, Ülkü Akyol Ardiç, Eyup Sabri Ercan
No abstract text is available yet for this article.
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27977467/time-to-discontinuation-of-second-generation-antipsychotics-versus-haloperidol-and-sulpiride-in-people-with-schizophrenia-a-naturalistic-comparative-study
#16
Hung-Yu Chan, Yi-Ju Pan, Jiahn-Jyh Chen, Chiung-Hsu Chen
PURPOSE: A retrospective study was conducted to evaluate the time to discontinuation (TTD) of the first- (FGAs) and second-generation antipsychotics (SGAs). METHODS: In total, 918 treatment episodes of patients with schizophrenia, initiated on one of the investigated drugs on an outpatient basis during 2004-2006, were entered into the study. The primary outcome was the duration of the investigated treatment episode. Discontinuation was defined when either patients were admitted or the investigated drug had been stopped for more than 28 days...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27941419/adjunctive-brexpiprazole-as-a-novel-effective-strategy-for-treating-major-depressive-disorder-a-systematic-review-and-meta-analysis
#17
Seoyoung Yoon, Sang Won Jeon, Young-Hoon Ko, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Changsu Han
PURPOSE/BACKGROUND: Brexpiprazole was approved for adjunctive treatment of major depressive disorder (MDD) in 2015. Because only a small number of randomized controlled trials have investigated the use of brexpiprazole in MDD, we performed a meta-analysis. METHODS/PROCEDURES: We systematically searched literatures in PubMed, Cochrane Library database, EMBASE, Google Scholar, and clinicaltrials.gov up to January 2016. The primary efficacy measure was the mean change in total Montgomery-Åsberg Depression Rating Scale (MADRS) score from baseline...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27941418/comparative-risk-of-ventricular-arrhythmia-and-sudden-cardiac-death-across-antidepressants-in-patients-with-depressive-disorders
#18
Chi-Shin Wu, Yu-Ting Tsai, Chao A Hsiung, Hui-Ju Tsai
OBJECTIVE: We aimed to evaluate the risk of ventricular arrhythmia (VA) and/or sudden cardiac death (SCD) associated with antidepressant use. METHODS: A cohort study was conducted using data from Taiwan's National Health Insurance Research Database from 2001 to 2012. A total of 793,460 new antidepressant users with depressive disorders were enrolled in the study. Outcomes were defined as the first principal diagnosis of VA or SCD in the emergency department or hospital discharge records...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27941417/is-there-any-association-between-use-of-antidepressants-and-preeclampsia-or-gestational-hypertension-a-systematic-review-of-current-studies
#19
Faruk Uguz
OBJECTIVE: Hypertension in pregnant women is an important medical problem, which can cause morbidity and mortality in the fetus. This study reviewed the current literature examining the potential relationship between use of antidepressants during pregnancy and preeclampsia or gestational hypertension. METHODS: PubMed was searched for English-language reports between January 1, 1995, and December 31, 2015, by using combinations of key words pregnancy, pregnancy complications, preeclampsia, gestational hypertension, and antidepressants...
February 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27930500/effect-of-rivastigmine-augmentation-in-treatment-of-male-patients-with-combat-related-chronic-posttraumatic-stress-disorder-a-randomized-controlled-trial
#20
Amir Rezaei Ardani, Golkoo Hosseini, Mohammad Reza Fayyazi Bordbar, Ali Talaei, Hesam Mostafavi Toroghi
BACKGROUND: Posttraumatic stress disorder (PTSD) is one of the chronic and disabling psychiatric disorders, particularly in combat veterans. In a case series, rivastigmine was suggested to be an effective augmentation in treatment of PTSD. The aim of the present study was to evaluate this finding in a randomized controlled trial. METHOD: A 12-week, double-blind, placebo-controlled clinical trial was performed on 36 male patients (aged 42-60 years) diagnosed with chronic, combat-related PTSD...
February 2017: Journal of Clinical Psychopharmacology
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