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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/30531478/assessment-of-the-abuse-potential-of-cebranopadol-in-nondependent-recreational-opioid-users-a-phase-1-randomized-controlled-study
#1
Karin Göhler, Marta Sokolowska, Kerri A Schoedel, Robert Nemeth, Elke Kleideiter, Isabella Szeto, Marie-Henriette Eerdekens
BACKGROUND: Cebranopadol is a nociceptin/orphanin FQ peptide/opioid receptor agonist with central antinociceptive activity. We hypothesize that this novel mechanism of action may lead to a lower risk of abuse compared with pure μ-opioid peptide receptor agonists. METHODS: We conducted a single-dose, nested-randomized, double-blind crossover study in nondependent recreational opioid users to evaluate the abuse potential of single doses of cebranopadol relative to hydromorphone immediate release and placebo...
December 6, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30531477/an-8-week-randomized-phase-2-double-blind-sequential-parallel-group-comparison-study-of-two-dose-levels-of-the-gabaa-positive-allosteric-modulator-pf-06372865-compared-with-placebo-as-an-adjunctive-treatment-in-outpatients-with-inadequate-response-to-standard
#2
Arthur Simen, Mark Whitlock, Ruolun Qiu, Jeff Miceli, Laura Zumpano, Michaele Du Metz, Pinky Dua, Brendon Binneman
BACKGROUND: Generalized anxiety disorder (GAD) is a common psychiatric disorder, but many patients experience only partial relief of symptoms with existing therapies. Benzodiazepines are effective in many cases but are limited by a number of significant adverse effects. PF-06372865 is a subtype-selective gamma-aminobutyric acid A (GABAA)-positive allosteric modulator lacking in functional activity at alpha 1-containing receptors that are believed to mediate many of these adverse effects...
December 6, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30531476/qtc-prolongation-associated-with-psychiatric-medications-a-retrospective-cross-sectional-study-of-adult-inpatients
#3
Wanda Shao, Shehzad Ayub, Robert Drutel, William C Heise, Richard Gerkin
OBJECTIVE: The aim of our study was to assess the impact of psychiatric medications and concomitant risk factors on the prevalence of QTc prolongation and torsades de pointes (TdP) in hospitalized subjects. We examined the association between individual risk scores and QTc prolongation and proposed an evidence-based protocol for electrocardiogram monitoring on psychotropic medications. METHOD: Electrocardiograms (ECGs) of subjects hospitalized over a 1-year period were analyzed for QTc prolongation, associated risk factors, and use of medications...
December 6, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30531475/exploring-brain-derived-neurotrophic-factor-val66met-polymorphism-and-extinction-learning-based-treatment-outcome-in-obsessive-compulsive-disorder-a-pilot-study
#4
Omer Linkovski, Michael G Wheaton, Jordana Zwerling, Zagaa Odgerel, Peter van Roessel, Maria Filippou-Frye, Anthony Lombardi, Brianna Wright, Shari A Steinman, Helen Blair Simpson, Francis Lee, Carolyn I Rodriguez
No abstract text is available yet for this article.
December 6, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30516576/statistics-commentary-series-commentary-no-30-propensity-scores
#5
David L Streiner
No abstract text is available yet for this article.
December 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30516575/effectiveness-of-venlafaxine-in-selective-serotonin-reuptake-inhibitor-resistant-obsessive-compulsive-disorder-experience-from-a-specialty-clinic-in-india
#6
Srinivas Balachander, Prabhath Gujjadi Kodancha, Shyam Sundar Arumugham, Jaisoorya T Sekharan, Janardhanan C Narayanaswamy, Y C Janardhan Reddy
BACKGROUND: Despite its favorable pharmacological profile and efficacy in major depression and anxiety disorders, evidence for the use of venlafaxine in obsessive-compulsive disorder (OCD) is limited. We sought to examine the real-world effectiveness of venlafaxine from a large database of an OCD clinic in India. METHODS: A total of 1704 consecutive patients who registered at the OCD clinic between June 2014 and December 2016 were evaluated with structured interviews and scales...
December 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30516574/switching-to-imipramine-versus-add-on-mirtazapine-in-venlafaxine-resistant-major-depression-a-10-week-randomized-open-study
#7
Víctor Navarro, Ilham Boulahfa, Amadeu Obach, Dídac Jerez, Maribel Diaz-Ricart, Cristóbal Gastó, Joana Guarch
PURPOSE/BACKGROUND: Newer-generation antidepressants used in monotherapy or in combination with other newer-generation antidepressants or other psychotropic drugs are usually preferred as first- or second-step treatment options in resistant depression. According to our clinical experience, tricyclic antidepressants still are one of our preferred first choices in treatment-resistant moderate to severe unipolar major depressive episodes. METHODS: This 10-week open-design randomized study assessed the effectiveness of switching to imipramine (adjusted to plasma levels) compared with add-on mirtazapine (30 mg/d) for treatment of moderate to severe unipolar major depressive episodes after a 10-week unsuccessful venlafaxine regimen (225-300 mg/d)...
December 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30516573/clinical-psychopharmacology-in-switzerland
#8
Pierre Baumann
No abstract text is available yet for this article.
December 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30489382/ropinirole-augmentation-for-depression-a-randomized-controlled-trial-pilot-study
#9
Ari A Gershon, Revital Amiaz, Haim Shem-David, Leon Grunhaus
OBJECTIVE: Evidence both from animal and human studies suggests a role for dopaminergic pathways in the treatment of depression. Ropinirole, a selective agonist of dopamine D2/D3, is in use for the treatment of parkinsonism. Preliminary evidence suggests that such agonists might be useful as antidepressants. We tested whether an add-on ropinirole is an effective in depressed patients. METHODS: We conducted a double-blind, randomized, placebo-controlled trial of add-on ropinirole in depressed patients unresponsive to at least one antidepressant...
November 26, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30489381/potential-explanations-for-increasing-methylphenidate-use-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-in-germany-from-2004-to-2013
#10
Ingo Langner, Ulrike Haug, Oliver Scholle, Christina Lindemann, Carsten Schröder, Oliver Riedel
BACKGROUND: Despite a decreasing population of children and adolescents, the cumulative total amount of dispensed methylphenidate (MPH), the first-choice treatment of attention-deficit/hyperactivity disorder (ADHD) in this age group, has increased dramatically in Germany. We investigated potential reasons for this increase such as changes in the ADHD prevalence over time and other potential explanations including the cumulative amount of dispensed MPH per person. METHODS: Based on German claims data, we calculated standardized annual ADHD prevalence rates, proportions of ADHD cases treated with MPH and/or psychotherapy, and mean cumulative defined daily doses of ADHD drugs for 3- to 17-year-old children and adolescents from 2004 to 2013...
November 26, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30431483/gabapentin-abuse-by-nasal-insufflation-a-case-report
#11
Zain Khalid, Mary-Anne Hennen, Lilian Aldana-Bernier
No abstract text is available yet for this article.
November 13, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30418255/clozapine-addition-following-brain-surgery-in-severe-primary-obsessive-compulsive-disorder-with-tardive-movement-disorder
#12
Trino Baptista, Hilarión Araujo, Jose de Leon
No abstract text is available yet for this article.
November 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30418254/two-manic-episodes-related-to-a-levetiracetam-based-treatment-in-a-34-year-old-female-patient-a-case-report
#13
Manon Meyrel, Marc Veyrier, Isabel Nieto, Frank Bellivier, Pierre A Geoffroy
No abstract text is available yet for this article.
November 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30339604/serum-non-high-density-lipoprotein-cholesterol-is-negatively-correlated-with-the-severity-of-depressive-disorder
#14
Xin Guo, Jing Wang, Jingjuan Pang, Yueying Lu, Shaobo Lv, Ning Wang, Jie Yuan
BACKGROUND: The aim of this study was to investigate the serum non-high-density lipoprotein cholesterol (non-HDLC) levels of first-episode, drug-naive depressive patients and the correlative factors. METHODS: The study group comprised 308 subjects including 150 drug-naive patients with first-episode depressive disorder and 158 control subjects diagnosed in the Affiliated Kailuan Mental Health Center, North China University of Science and Technology, Tangshan, Hebei, China, from June 2014 to November 2015...
October 19, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30379747/author-index-2018
#15
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30371636/predicting-unsuccessful-clozapine-treatment-after-first-use-in-adult-patients-with-psychotic-disorders
#16
Marieke M Beex-Oosterhuis, E R Rob Heerdink, Arthur R Van Gool, Rob J van Marum
PURPOSE/BACKGROUND: Cessation of clozapine therapy and insufficient response may result in relapse of psychotic symptoms and in clinical admissions. However, discontinuation rates are high. Identifying patients at risk for unsuccessful clozapine use might enable clinicians to direct specific attention to them. METHODS/PROCEDURES: Routinely collected data from a large insurance company were used to develop a simple prediction model for unsuccessful clozapine treatment in psychiatric patients 1 year after clozapine was first dispensed by a community pharmacy in the Netherlands...
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30346336/a-useful-example-of-pharmaco-electroencephalogram-science-invited-commentary-on-article-by-dr-dias-alves
#17
Max Fink
No abstract text is available yet for this article.
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30346335/the-role-of-atomoxetine-for-parkinson-disease-related-executive-dysfunction-a-systematic-review
#18
Carly B Warner, Andreina A Ottman, Jamie N Brown
BACKGROUND: Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the noradrenergic system's role in executive function, pharmacotherapy options that affect norepinephrine are of particular clinical interest in Parkinson disease-related executive dysfunction. OBJECTIVE: The aim of this study was to assess the efficacy and safety of atomoxetine for Parkinson disease-related executive dysfunction. METHODS: MEDLINE (1946 to May 2018) and EMBASE (1947 to May 2018) were queried using the search term combination: Parkinson's disease, Parkinson disease, inhibition, impulse behavior, impulse control disorder, executive function, executive dysfunction, cognition, cognitive dysfunction, cognitive defect, response inhibition, strategic planning, strategy, or verbal fluency and atomoxetine hydrochloride or atomoxetine...
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30346334/the-relationship-between-pregnancy-exposure-to-antidepressant-and-atypical-antipsychotic-medications-and-placental-weight-and-birth-weight-ratio-a-retrospective-cohort-study
#19
Jacqueline Frayne, Thinh Nguyen, Yvonne Hauck, Helena Liira, Jeffrey A Keelan
BACKGROUND: Psychotropic medication use in pregnancy has been associated with altered fetal growth. The aim of this study was to investigate the relationship between placental weight and placental weight-to-birth weight (PBW) ratio, as a potential marker of placental efficiency, and medication use in a cohort of women with severe mental illness in pregnancy. METHODS: A retrospective database analysis was carried out on a cohort of pregnant women with severe mental illness (242 singleton pregnancies) and grouped according to their psychotropic medication use...
December 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30346333/efficacy-and-safety-of-a-rapid-intravenous-injection-of-ketamine-0-5-mg-kg-in-treatment-resistant-major-depression-an-open-4-week-longitudinal-study
#20
Sonia Vidal, Marianne Gex-Fabry, Victor Bancila, Giorgio Michalopoulos, Delphine Warrot, Françoise Jermann, Alexandre Dayer, Virginie Sterpenich, Sophie Schwartz, Laszlo Vutskits, Nawaz Khan, Jean-Michel Aubry, Markus Kosel
BACKGROUND: Ketamine has been documented for its rapid antidepressant effects. However, optimal dose and delivery route have not yet been thoroughly investigated. The objectives of this study were to document the safety and test the antidepressant and antisuicidal effects of a single rapid 1-minute injection of ketamine 0.5 mg/kg in treatment-resistant depression (TRD). METHODS: Ten patients with TRD were included in an open, noncontrolled 4-week study and received a rapid intravenous dose of ketamine 0...
December 2018: Journal of Clinical Psychopharmacology
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