journal
MENU ▼
Read by QxMD icon Read
search

Journal of Clinical Psychopharmacology

journal
https://www.readbyqxmd.com/read/28195931/should-antipsychotic-medications-for-schizophrenia-be-given-for-a-lifetime-a-naturalistic-long-term-follow-up-study
#1
Ira D Glick, John M Davis, Daisy Zamora, Jacob Ballon, Meena Nuthi
BACKGROUND: Schizophrenia remains a major health problem despite antipsychotic medications that, for most patients, can decrease acute symptoms, decrease relapses, and contribute to partial and sometimes strong positive response in patients with chronic symptoms. What has not been clear-because a double-blind, randomized, placebo-controlled trial is not feasible or ethical-is how many years after the initial episode, or onset of antipsychotic treatment, should medication be continued to achieve the best global outcome...
February 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28195930/treatment-duration-with-long-acting-injectable-antipsychotics-after-in-hospital-initiation-a-retrospective-cohort-study
#2
Hans Rittmannsberger, Jan Rosenleitner, Gertraud Malsiner-Walli, Regina Werl, Barbara Rittmannsberger, Kurosch Yazdi
PURPOSE: Long-acting injectable (LAI) antipsychotics are recommended especially for patients with multiple admissions and poor adherence. The empirical basis of this strategy is a matter of debate. METHODS: In a retrospective cohort study extending over 6 years, all patients admitted for inpatient treatment with a diagnosis of psychotic disorders according to International Statistical Classification of Diseases and Related Health Problems, 10th Revision (F2) were screened for treatment episodes with a new start of an LAI...
February 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28195853/efficacy-of-brexpiprazole-as-adjunctive-treatment-in-major-depressive-disorder-with-irritability-post-hoc-analysis-of-2-pivotal-clinical-studies
#3
Maurizio Fava, Emmanuelle Weiller, Peter Zhang, Catherine Weiss
No abstract text is available yet for this article.
February 11, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28187008/guarding-the-gate-remote-structured-assessments-to-enhance-enrollment-precision-in-depression-trials
#4
Marlene P Freeman, James Pooley, Martina J Flynn, Lee Baer, David Mischoulon, David Mou, Maurizio Fava
BACKGROUND: Failed treatment trials are common in major depressive disorder and treatment-resistant depression, and remotely performed multifaceted, centralized structured interviews can potentially enhance signal detection by ensuring that enrolled patients meet eligibility criteria. METHODS: We assessed the use of a specific remote structured interview that validated the diagnosis, level of treatment resistance, and depression severity. The objectives were to (1) assess the rate at which patients who were deemed eligible for participation in trials by site investigators were ineligible, (2) assess the reasons for ineligibility, (3) compare rates of ineligibility between academic and nonacademic sites, (4) compare eligibility between US and non-US sites, and (5) report the placebo response rates in trials utilizing this quality assurance approach, comparing its placebo response rates with those reported in the literature...
February 10, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28187007/clinicaltrials-gov-inhaled-loxapine-and-safety-issues
#5
Richard I Shader
No abstract text is available yet for this article.
February 10, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28181982/vilazodone-associated-hyperglycemia-in-a-patient-with-diabetes-a-case-report
#6
Anil Kumar Buruganahalli Nagendrappa
No abstract text is available yet for this article.
February 8, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28166082/differential-risk-of-peptic-ulcer-among-users-of-antidepressants-combined-with-nonsteroidal-anti-inflammatory-drugs
#7
Ju-Young Shin, Inmyung Song, Jin-Ho Lee, Jong Lull Yoon, Jun Soo Kwon, Byung-Joo Park
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been reported to have an increased risk of gastrointestinal adverse events, and the risk may be further increased by combined use of nonsteroidal anti-inflammatory drugs (NSAIDs). However, little has been known about the risk of peptic ulcer associated with other classes of antidepressants or individual antidepressants combined with NSAIDs. METHODS: We conducted a retrospective cohort study to define the risk of peptic ulcer associated with combined use of antidepressants and NSAIDs, as compared with use of antidepressants alone...
February 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28166081/the-art-of-pharmacotherapy-reflections-on-pharmacophobia
#8
Jose de Leon, Carlos De Las Cuevas
PURPOSE/BACKGROUND: This commentary deals with the neglected issue of the art of psychopharmacology by recounting the authors' journeys. METHODS/PROCEDURES: First, a model of medical science situated within the history of medicine is described including (1) a limitation of the mathematical model of science, (2) the distinction between mechanistic science and mathematical science, (3) how this distinction is applied to medicine, and (4) how this distinction is applied to explain pharmacology to psychiatrists...
February 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28146001/clinical-use-of-mood-stabilizers-with-antidepressants-in-asia-report-from-the-research-on-asian-psychotropic-prescription-patterns-for-antidepressants-reap-ad-projects-in-2004-and-2013
#9
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen F K Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy A Kallivayalil, Andi J Tanra, Margarita M Maramis, Winston W Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
OBJECTIVE: As most reports concerning treatment with combinations of mood stabilizer (MS) with antidepressant (AD) drugs are based in the West, we surveyed characteristics of such cotreatment in 42 sites caring for the mentally ill in 10 Asian countries. METHODS: This cross-sectional, pharmacoepidemiologic study used 2004 and 2013 data from the REAP-AD (Research Study on Asian Psychotropic Prescription Patterns for Antidepressants) to evaluate the rates and doses of MSs given with ADs and associated factors in 4164 psychiatric patients, using standard bivariate methods followed by multivariable logistic regression modeling...
January 31, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28146000/efficacy-of-desvenlafaxine-compared-with-placebo-in-major-depressive-disorder-patients-by-age-group-and-severity-of-depression-at-baseline
#10
Daniel Mosca, Min Zhang, Rita Prieto, Matthieu Boucher
PURPOSE: This post hoc meta-analysis evaluated the efficacy and safety of desvenlafaxine 50 and 100 mg versus placebo across age groups and severity of depression at baseline in patients with major depressive disorder. METHODS: Data from placebo and desvenlafaxine 50-mg and 100-mg dose arms were pooled from 9 short-term, placebo-controlled, major depressive disorder studies (N = 4279). Effects of age (18-40 years, >40 to <55 years, 55-<65 years, and ≥65 years) and baseline depression severity (mild, 17-item Hamilton Rating Scale for Depression total score [HAM-D17] ≤18; moderate, HAM-D17 >18 to <25; severe, HAM-D17 ≥25) on desvenlafaxine efficacy were assessed using analysis of covariance for continuous end points and logistic regression for categorical end points...
January 31, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28145999/short-term-effects-of-methylphenidate-on-math-productivity-in-children-with-attention-deficit-hyperactivity-disorder-are-mediated-by-symptom-improvements-evidence-from-a-placebo-controlled-trial
#11
Anne Fleur Kortekaas-Rijlaarsdam, Marjolein Luman, Edmund Sonuga-Barke, Pierre M Bet, Jaap Oosterlaan
BACKGROUND: Although numerous studies report positive effects of methylphenidate on academic performance, the mechanism behind these improvements remains unclear. This study investigates the effects of methylphenidate on academic performance in children with attention-deficit/hyperactivity disorder (ADHD) and the mediating and moderating influence of ADHD severity, academic performance, and ADHD symptom improvement. METHODS: Sixty-three children with ADHD participated in a double-blind placebo-controlled crossover study comparing the effects of long-acting methylphenidate and placebo...
January 31, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28145998/long-acting-aripiprazole-in-comorbid-bipolar-disorder-and-borderline-personality-disorder-and-substance-abuse
#12
Jesús Salomón Martínez, Asur Rahuel Sánchez Caballero
No abstract text is available yet for this article.
January 31, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28141623/activating-and-sedating-adverse-effects-of-second-generation-antipsychotics-in-the-treatment-of-schizophrenia-and-major-depressive-disorder-absolute-risk-increase-and-number-needed-to-harm
#13
Leslie Citrome
PURPOSE/BACKGROUND: Activating and sedating adverse effects of antipsychotics can be obstacles to their use. METHODS/PROCEDURES: This study quantified the activating and sedating properties of first-line oral second-generation antipsychotics by examining the rates of adverse reactions as reported in product labeling for the indications of schizophrenia and adjunctive treatment of major depressive disorder. Additional data sources included regulatory documents, study synopses, and published study reports...
January 30, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28141622/5-ht6-receptor-antagonist-as-an-adjunct-treatment-targeting-residual-symptoms-in-patients-with-schizophrenia-unexpected-sex-related-effects-double-blind-placebo-controlled-trial
#14
Margarita Morozova, Denis Burminskiy, George Rupchev, Taissia Lepilkina, Sergey Potanin, Allan Beniashvili, Yan Lavrovsky, Natalia Vostokova, Alexander Ivaschenko
BACKGROUND: Treating patients who experience residual psychotic symptoms during remission of schizophrenia remains one of the most challenging problems. The mechanisms underlying these symptoms differ from those of acute hallucinations and delusions. 5-HT6 receptor antagonists have been considered promising agents in treatment of residual psychotic symptoms and cognitive dysfunction. The aim of the study was to assess the efficacy of a selective 5-HT6 inhibitor Avisetron in the reduction of residual psychotic symptoms in patients with schizophrenia on stable antipsychotic therapy...
January 30, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28141621/high-incidence-and-prevalence-of-drug-related-movement-disorders-in-young-patients-with-psychotic-disorders
#15
Thierry Q Mentzel, Ritsaert Lieverse, Oswald Bloemen, Wolfgang Viechtbauer, Peter N van Harten
BACKGROUND: Drug-related movement disorders (DRMDs) reduce quality of life and contribute to medication noncompliance of patients with psychotic disorders. Little is known about the epidemiology of DRMDs in relatively young patients a few years after onset of psychosis. This is an important period to study, as the impact of the antipsychotic treatment on the long-term potentiation of the neural pathways associated with psychotic disorders and DRMDs is still minimal. This study investigated the prevalence, incidence, persistence, and clinical correlates of DRMDs in patients during their first years after disease onset...
January 30, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28129315/lurasidone-and-mood-stabilizers-in-treatment-resistant-unipolar-depression-a-case-report-study
#16
Nicolas A Nuñez, Gabriella Gobbi
No abstract text is available yet for this article.
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28129314/neurocognitive-benefits-of-second-generation-antipsychotics-versus-placebo-insufficient-evidence-based-on-a-systematic-review
#17
Hiroyoshi Takeuchi, Sadhana Thiyanavadivel, Gagan Fervaha, Gary Remington
No abstract text is available yet for this article.
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28129313/clinical-outcomes-of-concomitant-use-of-warfarin-and-selective-serotonin-reuptake-inhibitors-a-multidatabase-observational-cohort-study
#18
Yaa-Hui Dong, Katsiaryna Bykov, Niteesh K Choudhry, Macarius M Donneyong, Krista F Huybrechts, Raisa Levin, Sebastian Schneeweiss, Joshua J Gagne
BACKGROUND: Patients treated with warfarin are often coprescribed selective serotonin reuptake inhibitors (SSRIs) for coexisting depression. Some SSRIs are potent CYP2C9 inhibitors that may increase warfarin plasma concentrations and the risk of bleeding. We aimed to examine the effect of the putative CYP2C9-mediated warfarin-SSRI interaction on clinical outcomes. METHODS: We conducted an observational cohort study among warfarin initiators who had a subsequent SSRI prescription in 5 US claims databases...
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28129312/the-effect-of-glycopyrrolate-on-nocturnal-sialorrhea-in-patients-using-clozapine-a-randomized-crossover-double-blind-placebo-controlled-trial
#19
Wai Hong Man, Jantine C A Colen-de Koning, Peter F J Schulte, Wiepke Cahn, Ingrid M M van Haelst, Hieronymus J Doodeman, Toine C G Egberts, Eibert R Heerdink, Ingeborg Wilting
BACKGROUND: Nocturnal sialorrhea is one of the most frequent adverse events in clozapine treatment. Symptomatic management of sialorrhea usually consists of off-label treatment with anticholinergic agents. The aim of the current study is to evaluate the efficacy and safety of glycopyrrolate in patients using clozapine that experience sialorrhea. METHODS: In a double-blind randomized crossover trial, patients with nocturnal sialorrhea (n = 32) were randomized to treatment with glycopyrrolate 1 mg or placebo...
January 26, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28129311/is-mirtazapine-an-effective-treatment-for-nausea-and-vomiting-of-pregnancy-a-case-series
#20
Oguz Omay, Adrienne Einarson
No abstract text is available yet for this article.
January 26, 2017: Journal of Clinical Psychopharmacology
journal
journal
28217
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"