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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/29927781/long-term-tolerability-and-safety-of-pharmacological-treatment-of-adult-attention-deficit-hyperactivity-disorder-a-6-year-prospective-naturalistic-study
#1
Dan Edvinsson, Lisa Ekselius
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a behavioral disorder typically treated with stimulants and atomoxetine. Data on long-term tolerability and safety of such pharmacological treatment in subjects diagnosed in adulthood are limited. METHODS: A cohort of adults diagnosed with ADHD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria was followed-up on an average of 6 years after first evaluation. Of 168 adults, 112 (67%) who initiated medication were available for follow-up...
June 20, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912786/a-12-month-open-label-extension-study-of-the-safety-and-tolerability-of-lisdexamfetamine-dimesylate-for-major-depressive-disorder-in-adults
#2
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, Brooke Geibel, Matthew Dauphin, Roger S McIntyre, Richard Weisler, Olga Brawman-Mintzer, Joan Gu, Manisha Madhoo
PURPOSE/BACKGROUND: Psychostimulant augmentation is considered a potential treatment strategy for individuals with major depressive disorder who do not adequately respond to antidepressant monotherapy. The primary objective of this 12-month open-label extension study was to evaluate the safety and tolerability of lisdexamfetamine dimesylate (LDX) as augmentation therapy to an antidepressant in adults with major depressive disorder. METHODS/PROCEDURES: Eligible adults who completed 1 of 3 short-term antecedent LDX augmentation of antidepressant monotherapy studies were treated with dose-optimized LDX (20-70 mg) for up to 52 weeks while continuing on the index antidepressant (escitalopram, sertraline, venlafaxine extended-release, or duloxetine) assigned during the antecedent short-term studies...
June 16, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912802/analysis-of-clozapine-use-and-safety-by-using-comprehensive-national-data-from-the-japanese-clozapine-patient-monitoring-service
#3
Ken Inada, Hidehiro Oshibuchi, Jun Ishigooka, Katsuji Nishimura
OBJECTIVE: The aim of this study was to investigate clozapine use and its associated adverse effects in patients in Japan. METHODS: We analyzed data recorded from July 2009 to January 2016 (N = 3780 patients) in the Clozaril Patient Monitoring Service, which was established in Japan in 2009 and includes all Japanese patients who have been prescribed clozapine. RESULTS: The treatment discontinuation rate was 23.9% (869/3780 cases). The average ± SD treatment duration was 234...
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912801/bruising-in-a-depressed-patient-self-inflicted-or-adverse-effect-of-antidepressants-an-unexpected-cause-scurvy
#4
Pierre-Alexandre Lasica, Cécile Lavenu-Bombled, Olivier Lambotte, Florence Gressier
No abstract text is available yet for this article.
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912800/neurological-deficits-after-lithium-intoxication-in-a-bipolar-woman-with-catatonia-treated-with-ect
#5
Pierpaolo Medda, Chiara Socci, Cristina Toni, Irene Pergentini, Francesco Forfori, Filippo Sean Giorgi, Giulio Perugi
No abstract text is available yet for this article.
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912799/adjunct-aripiprazole-reduces-prolactin-and-prolactin-related-adverse-effects-in-premenopausal-women-with-psychosis-results-from-the-daamsel-clinical-trial
#6
Deanna L Kelly, Megan M Powell, Heidi J Wehring, MacKenzie A Sayer, Ann Marie Kearns, Ann L Hackman, Robert W Buchanan, Rebecca B Nichols, Heather A Adams, Charles M Richardson, Gopal Vyas, Robert P McMahon, Amber K Earl, Kelli M Sullivan, Fang Liu, Sarah E Luttrell, Faith B Dickerson, Stephanie M Feldman, Supriya Narang, Maju M Koola, Peter F Buckley, Jill A RachBeisel, Joseph P McEvoy
PURPOSE/BACKGROUND: Prolactin-related adverse effects contribute to nonadherence and adverse health consequences, particularly in women with severe mental illness. Treating these adverse effects may improve treatment acceptability, adherence, and long-term outcomes. METHODS/PROCEDURES: Premenopausal women with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder were recruited for a randomized, double-blind, placebo-controlled 16-week trial of adjunct aripiprazole (5-15 mg/d)...
June 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912798/phase-iib-trial-of-an-%C3%AE-7-nicotinic-receptor-partial-agonist-with-and-without-nicotine-patch-for-withdrawal-associated-cognitive-deficits-and-tobacco-abstinence
#7
Randi Melissa Schuster, Gladys N Pachas, Luke Stoeckel, Corinne Cather, Mireya Nadal, David Mischoulon, David A Schoenfeld, Haiyue Zhang, Christine Ulysse, Elisabeth B Dodds, Sara Sobolewski, Vicenta Hudziak, Ailish Hanly, Maurizio Fava, A Eden Evins
PURPOSE/BACKGROUND: The objective of this study was to determine whether a novel α7 nicotinic acetylcholine receptor partial agonist improves cognition during nicotine withdrawal and improves abstinence rates. To do so, the effect of the α7 nicotinic acetylcholine receptor partial agonist, encenicline, on cognition and abstinence was evaluated when given as monotherapy and when combined with transdermal nicotine patch (nicotine replacement therapy [NRT]). METHODS: Adult daily smokers, n = 160, who were motivated to quit smoking completed cognitive testing at satiated baseline and after overnight abstinence and then were randomized to receive a 12-week trial of encenicline 1 mg twice daily or identical placebo the day of the overnight abstinent cognitive testing...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912797/successful-add-on-vortioxetine-for-an-adolescent-with-attention-deficit-hyperactivity-disorder
#8
Ahmed Naguy, Bibi Alamiri
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912796/remaining-need-for-in-vitro-test-to-elucidate-5-hydroxytryptamine-2c-receptor-functioning
#9
Svetlana A Ivanova, Melloney J Dröge, Haukeline H Volders, Bernard J van Vliet, Nikolay A Bokhan, Fokko J Bosker, Anton J M Loonen
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912795/editors-note-paper-selected-for-the-mitchell-b-balter-award-2017
#10
(no author information available yet)
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912794/intraindividual-and-interindividual-variability-of-olanzapine-trough-concentrations-in-patients-treated-with-the-long-acting-injectable-formulation
#11
Sara Baldelli, Massimo C Mauri, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Chiara Rovera, Emilio Clementi, Dario Cattaneo
BACKGROUND: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate the intraindividual and interindividual variability of olanzapine concentrations with time in patients on maintenance therapy with the LAI formulation carried out in the routine clinical practice. METHODS: To address this issue, we carried out a retrospective analysis of therapeutic drug monitoring of olanzapine concentrations in 21 schizophrenic patients on maintenance LAI olanzapine...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912793/do-antiepileptic-drugs-used-during-electroconvulsive-therapy-impact-treatment-process
#12
Sertaç Ak, Nadir Yalçin
PURPOSE: Whether the antiepileptic agents used by patients before the treatment should be discontinued after the initiation of the electroconvulsive therapy (ECT), which is one of the most effective treatment options in psychiatry, is a dilemma frequently faced by clinicians. Recently, there has been an increased interest in this subject. This study aimed to determine the impact of antiepileptic agents on ECT process in the event of continued use in the course of the therapy. METHODS: From among the patients on an ECT therapy in the Psychiatry Clinic of Hacettepe University Hospital since 2010, a total of 39 patients who continued to use the antiepileptic agent they were taking prior to the ECT therapy were determined and included in the study...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912792/neurocognitive-effects-of-agomelatine-treatment-in-schizophrenia-patients-suffering-from-comorbid-depression-results-from-the-agopsych-study
#13
Susanne Englisch, Hanna Sophie Jung, Sarah Eisenacher, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Cognitive impairment in schizophrenia is highly disabling and remains one of the major therapeutic challenges. Agomelatine (AGO), an agonist at melatonergic MT1/MT2 receptors and antagonist at 5-HT2C receptors, increases dopamine and norepinephrine in the prefrontal cortex and may therefore have the potential of improving neurocognition in patients with schizophrenia. METHODS: Twenty-seven patients with schizophrenia and comorbid depression were treated with AGO in addition to stable doses of antipsychotic drugs...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912791/amantadine-associated-bullous-pemphigoid
#14
Sarah Hoffer, Ana Hategan, James A Bourgeois
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912790/the-prescription-of-benzodiazepines-for-panic-disorder-time-for-an-evidence-based-educational-approach
#15
Antonio E Nardi, Fiammetta Cosci, Richard Balon, Steven J Weintraub, Rafael C Freire, John H Krystal, Thomas Roth, Edward K Silberman, Nicoletta Sonino, Giovanni A Fava, Vladan Starcevic, Steven L Dubovsky, Carl Salzman, Karl Rickels, David J Greenblatt, Richard I Shader, Guy Chouinard
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912789/quetiapine-excretion-into-human-breast-milk
#16
Parvaneh Yazdani-Brojeni, Reo Tanoshima, Nobuko Taguchi, Facundo Garcia-Bournissen, Izhar Wallach, Myla E Moretti, Zulfikarali Verjee, Shinya Ito
BACKGROUND: Risk assessment of the use of quetiapine during breastfeeding is challenging owing to a paucity of data. METHODS: A pharmacokinetic study was conducted in lactating women who were taking quetiapine. The primary endpoint was to determine quetiapine concentration profiles in milk and estimated infant exposure levels. Multiple milk and a single blood quetiapine concentrations were determined using a highly sensitive liquid chromatography with tandem mass spectroscopy method...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912788/maintenance-ketamine-therapy-for-treatment-resistant-depression
#17
Shaina Archer, Carson Chrenek, Jennifer Swainson
BACKGROUND: Previous studies have demonstrated ketamine to have a rapid antidepressant effect in some patients with treatment-resistant depression (TRD), but the effect is unfortunately not sustained in the long term. In this study, we report on the clinical use of ongoing maintenance ketamine infusions in a group of patients with TRD, beyond an acute course of 6 to 8 ketamine infusions. METHODS: This retrospective case series reports on 11 patients with TRD who received maintenance ketamine infusions, defined as treatments beyond an initial series of up to 8 infusions...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912787/acute-anisocoria-related-to-citalopram-a-case-report
#18
Andrea De Angelis, Lucia Ricciardi
No abstract text is available yet for this article.
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29901567/association-of-antidepressant-use-with-drug-related-extrapyramidal-symptoms-a-pharmacoepidemiological-study
#19
Michael Y Guo, Mahyar Etminan, Ric M Procyshyn, David D Kim, Ali Samii, Abbas Kezouh, Bruce C Carleton
BACKGROUND: Antidepressants are one of the most prescribed classes of medications. A number of case reports have linked these drugs to extrapyramidal symptoms (EPSs), but no large epidemiologic study to date has examined this association. We sought to quantify the association of EPSs with different antidepressants by undertaking a large pharmacoepidemiologic study. METHODS: A nested case-control study was conducted using a large health claims database in the United States from June 2006 to December 2015...
June 12, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29901566/supatherapeutic-serum-clozapine-concentration-after-transition-from-traditional-to-electronic-cigarettes
#20
Farah Khorassani, Milena Kaufman, Leonardo V Lopez
No abstract text is available yet for this article.
June 12, 2018: Journal of Clinical Psychopharmacology
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