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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/30303862/is-there-always-a-right-or-wrong-comments-on-the-fda-warnings-about-triptans-and-the-serotonin-syndrome
#1
Richard I Shader, David J Greenblatt
No abstract text is available yet for this article.
October 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30303861/methylenedioxymethamphetamine-mdma-in-psychiatry-pros-cons-and-suggestions
#2
Susan Schenk, David Newcombe
BACKGROUND: For a number of mental health disorders, including posttraumatic stress disorders (PTSD), there are not many available treatment options. Recently, there has been renewed interest in the potential of methylenedioxymethamphetamine (MDMA) to restore function for patients with these disorders. The primary hypothesis is that MDMA, via prosocial effects, increases the ability of patients to address the underlying psychopathology of the disorder. However, the use of MDMA poses potential problems of neurotoxicity, in addition to its own potential for misuse...
October 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300296/statistics-commentary-series-commentary-no-29-network-meta-analysis
#3
David L Streiner
No abstract text is available yet for this article.
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300295/age-impacts-olanzapine-exposure-differently-during-use-of-oral-versus-long-acting-injectable-formulations-an-observational-study-including-8-288-patients
#4
Marit Tveito, Robert L Smith, Espen Molden, Tore Haslemo, Helge Refsum, Cecilie Hartberg, Christoph U Correll, Gudrun Høiseth
PURPOSE: Olanzapine is a commonly prescribed antipsychotic available as oral and long-acting injectable (LAI) formulations. Data are lacking on the use and safety of olanzapine-LAI in older patients. The aim of this study was to investigate the effect of increasing age on olanzapine exposure during oral versus LAI administration in a real-life setting. METHODS: This observational study was based on routine therapeutic drug monitoring data collected during 2005-2017...
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300294/in-memoriam-bernard-j-carroll-md-phd
#5
Richard I Shader
No abstract text is available yet for this article.
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300293/very-low-dose-mirtazapine-7-5-mg-in-treatment-of-acute-antipsychotic-associated-akathisia
#6
Michael Poyurovsky, Abraham Weizman
BACKGROUND: Some evidence suggests that off-label use of mirtazapine (15 mg) is effective in treatment of acute antipsychotic-associated akathisia (AAA). We analyzed whether a lower dose of mirtazapine (7.5 mg) maintained its antiakathisia properties while exhibiting better tolerability in patients with schizophrenia and mood disorders who developed acute AAA. METHODS: Medical charts were retrospectively evaluated for 12 patients with AAA. All scored at least 2 (mild akathisia) on the Barnes Akathisia Rating Scale (BARS) and were treated with mirtazapine (7...
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300292/hallucinogen-persisting-perception-disorder-after-ibogaine-treatment-for-opioid-dependence
#7
Thomas Knuijver, Maarten Belgers, Wiebren Markus, Robbert-Jan Verkes, Toon van Oosteren, Arnt Schellekens
No abstract text is available yet for this article.
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300291/clinical-characteristics-of-patients-with-schizophrenia-who-successfully-discontinued-antipsychotics-a-literature-review
#8
Hideaki Tani, Takefumi Suzuki, W Wolfgang Fleischhacker, Masayuki Tomita, Masaru Mimura, Hiroyuki Uchida
PURPOSE/BACKGROUND: Although discontinuing antipsychotics clearly increases the risk of relapse in schizophrenia, some patients remain clinically well without continuous antipsychotic treatment. However, data on the characteristics of such patients are still scarce. METHODS/PROCEDURES: A systematic literature review was conducted to identify predictive factors for successful antipsychotic discontinuation in schizophrenia using PubMed (last search; June 2018) with the following search terms: (antipsychotic* or neuroleptic) AND (withdraw* or cessat* or terminat* or discontinu*) AND (schizophreni* or psychosis)...
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30300290/risperidone-but-not-quetiapine-treatment-is-associated-with-increased-appetite-but-not-satiety-hormones-in-children-during-an-oral-glucose-tolerance-test-a-pilot-study
#9
Ying Fai Ngai, Angela M Devlin, Constadina Panagiotopoulos
BACKGROUND: Second-generation antipsychotics (SGAs) are commonly used to treat children with mental health conditions (MHCs) but are associated with adverse effects including obesity, hypertension, dyslipidemia, and type 2 diabetes. The mechanisms underlying these complications are unknown, but it has been suggested that SGAs increase appetite leading to weight gain. The present objective was to perform a pilot study to investigate appetite and satiety hormones in SGA-treated (risperidone or quetiapine) and SGA-naive children with similar mental health conditions...
October 8, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30286000/antisense-oligonucleotides-in-psychiatric-disorders
#10
Heiko Graf, Claudia Diana Wurster
No abstract text is available yet for this article.
October 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30285999/withdrawal-emergent-dyskinesia-after-acute-discontinuation-of-risperidone-in-a-child-with-autism-spectrum-disorder
#11
Maanvi Kumar, Richard Mattison, Raman Baweja
No abstract text is available yet for this article.
October 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30285998/eleven-years-of-clozapine-experience-in-autism-spectrum-disorder-efficacy-and-tolerance
#12
Maud Rothärmel, Fanny Szymoniak, Charlotte Pollet, Laurène Beherec, Pierre Quesada, Sophie Leclerc, Amina Belhaine, Antoine Rosier, Olivier Guillin
BACKGROUND: Autism spectrum disorders (ASDs) are neurodevelopmental disorders that comprise wide graduated clinical expressions but similar core symptoms (repetitive, stereotyped behavior, and social communication disabilities). Many patients with ASD have disruptive behaviors like aggressiveness, temper tantrums, or self-injury that interfere with their socializations, their learning abilities, and their quality of life. These behaviors represent a common target for pharmacology. Beherec et al (J Clin Psychopharmacol...
October 3, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30273199/trends-of-polypharmacy-and-prescription-patterns-of-antidepressants-in-asia
#13
Cho-Yin Huang, Shu-Yu Yang, Ramin Mojtabai, Shu-Ku Lin, Yan-Ling He, Mian-Yoon Chong, Gabor Ungvari, Chay-Hoon Tan, Yu-Tao Xiang, Norman Sartorius, Naotaka Shinfuku, Lian-Yu Chen
PURPOSE: Little is known regarding the trend of polypharmacy in Asia. We used data from 5 Asian countries to examine the patterns of antidepressant (AD) prescription and trends of psychotropic polypharmacy over time. METHODS: We used the cross-sectional, pharmacoepidemiological data from 2004 and 2013 REAP-AD (Research on Asian Psychotropic Prescription Patterns for Antidepressants) to examine the patterns of AD prescriptions in clinical settings in China, Japan, Korea, Singapore, and Taiwan...
September 28, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30247179/electroencephalogram-modifications-associated-with-atypical-strict-antipsychotic-monotherapies
#14
Manuel Dias Alves, Jean Arthur Micoulaud-Franchi, Nicolas Simon, Jean Vion-Dury
BACKGROUND: Antipsychotics produce electroencephalogram (EEG) modifications and increase the risk of epileptic seizure. These modifications remain sparsely studied specifically for atypical antipsychotics. In this context, our study focuses on EEG modifications associated with atypical strict antipsychotic monotherapies. METHODS: Electroencephalogram recordings of 84 psychiatric patients treated with atypical antipsychotics in strict monotherapy (clozapine, n = 22; aripiprazole, n = 22; olanzapine, n = 17; risperidone, n = 9; quetiapine, n = 8; risperidone long-acting injection, n = 4; and paliperidone long-acting injection, n = 2) were analyzed...
September 21, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30212396/why-do-you-keep-telling-me-that-drug-drug-interactions-are-important-in-psychopharmacology-when-i-do-not-see-them-in-my-clinical-practice-my-failure-to-convince-clinicians
#15
Jose de Leon
No abstract text is available yet for this article.
September 12, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30192255/acetazolamide-for-antipsychotic-associated-weight-gain-in-schizophrenia
#16
Anil Kakunje, Ashwini Prabhu, Sindhu Priya Es, Ravichandra Karkal, Rahyanath K Pookoth, Rekha Pd
No abstract text is available yet for this article.
September 6, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30124585/melancholic-symptoms-in-bipolar-ii-depression-and-responsiveness-to-lamotrigine-in-an-exploratory-pilot-study
#17
Evyn M Peters, Rudy Bowen, Lloyd Balbuena
BACKGROUND: In this exploratory pilot study we reanalyzed data from a previous randomized, double-blind, placebo-controlled trial of lamotrigine for bipolar II depression in which lamotrigine was not superior to placebo to determine if splitting the sample into melancholic and nonmelancholic subgroups revealed a significant treatment effect. METHODS: Adult outpatients (n = 150) in an acute bipolar II depressive episode completed 8 weeks of treatment with lamotrigine (titrated to 200 mg/d) or placebo...
October 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30124584/individual-differences-in-working-memory-capacity-predict-topiramate-related-cognitive-deficits
#18
Christopher M Barkley, Zhenhong Hu, Ann M Fieberg, Lynn E Eberly, Angela K Birnbaum, Ilo E Leppik, Susan E Marino
PURPOSE/BACKGROUND: Topiramate (TPM) and lorazepam (LZP) are two examples of frequently prescribed medications that are associated with a high incidence of cognitive impairment; however, the factors that underlie interindividual differences in side effect profiles have not been fully characterized. Our objective was to determine whether working memory capacity (WMC), the amount of information that can be stored and manipulated in memory over short time intervals, is one such factor. METHODS/PROCEDURES: Twenty-nine healthy volunteers completed a double-blind, randomized, placebo-controlled crossover study during which they received placebo (PBO), TPM, and LZP in random order...
October 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30124583/digit-symbol-substitution-test-the-case-for-sensitivity-over-specificity-in-neuropsychological-testing
#19
Judith Jaeger
PURPOSE/BACKGROUND: Development of the Digit Symbol Substitution Test (DSST) was initiated over a century ago as an experimental tool to understand human associative learning. Its clinical utility, owing to its brevity and high discriminant validity, was first recognized in the 1940s, and now the DSST is among the most commonly used tests in clinical neuropsychology. METHODS: Specific studies and articles were reviewed to illustrate what the test measures, to evaluate its sensitivity to change, and to discuss its use in clinical practice...
October 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30119076/population-pharmacokinetic-pharmacodynamic-modeling-of-a-novel-methylphenidate-extended-release-orally-disintegrating-tablet-in-pediatric-patients-with-attention-deficit-hyperactivity-disorder
#20
Nathan S Teuscher, Carolyn R Sikes, Russ McMahen, Dorothy Engelking
PURPOSE/BACKGROUND: A methylphenidate (MPH) extended-release orally disintegrating tablet (MPH XR-ODT) formulation was recently approved for attention-deficit/hyperactivity disorder treatment in children 6 to 17 years of age. This analysis sought to develop a population pharmacokinetic (PK)/pharmacodynamic (PD) model to describe MPH XR-ODT PD-response data in a classroom study and use the model to simulate PD responses for a range of body weights and doses. METHODS/PROCEDURES: The MPH XR-ODT PK/PD model was developed with pediatric and adult PK data from prior studies and efficacy data from a laboratory classroom study in children with attention-deficit/hyperactivity disorder...
October 2018: Journal of Clinical Psychopharmacology
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