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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/27902528/increased-brain-lactate-during-depressive-episodes-and-reversal-effects-by-lithium-monotherapy-in-drug-naive-bipolar-disorder-a-3-t-1h-mrs-study
#1
Rodrigo Machado-Vieira, Marcus V Zanetti, Maria C Otaduy, Rafael T De Sousa, Marcio G Soeiro-de-Souza, Alana C Costa, Andre F Carvalho, Claudia C Leite, Geraldo F Busatto, Carlos A Zarate, Wagner F Gattaz
OBJECTIVE: Mitochondrial dysfunction and energy metabolism impairment are key components in the pathophysiology of bipolar disorder (BD) and may involve a shift from aerobic to anaerobic metabolism. Measurement of brain lactate in vivo using proton magnetic resonance spectroscopy (H-MRS) represents an important tool to evaluate mitochondrial and metabolic dysfunction during mood episodes, as well as to monitor treatment response. To date, very few studies have quantified brain lactate in BD...
November 28, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27861197/statistics-commentary-series-commentary-no-18-meta-analysis-part-1-what-it-is
#2
David L Streiner
No abstract text is available yet for this article.
November 17, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27861196/lavender-oil-preparation-silexan-for-treating-anxiety-an-updated-meta-analysis
#3
Marcelo B Generoso, Amanda Soares, Ivan T Taiar, Quirino Cordeiro, Pedro Shiozawa
No abstract text is available yet for this article.
November 17, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27861195/risperidone-associated-rhabdomyolysis-without-neuroleptic-malignant-syndrome-a-case-report
#4
Mei Ling Look, Yang Liang Boo, Pek Woon Chin, Fan Kee Hoo
No abstract text is available yet for this article.
November 17, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27846048/scopolamine-ointment-for-clozapine-associated-sialorrhea-a-case-report
#5
Takashi Goto, Miyoko Kato, Yukiko Matsumura, Naoto Omata, Masato Higashima, Yuji Wada, Mari Yoshida, Kyohei Watanabe, Tetsuya Takahashi
No abstract text is available yet for this article.
November 14, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27846049/agomelatine-for-the-treatment-of-major-depressive-episodes-in-schizophrenia-spectrum-disorders-an-open-prospective-proof-of-concept-study
#6
Susanne Englisch, Hanna Sophie Jung, Antje Lewien, Anna Becker, Ulrike Nowak, Hanna Braun, Jascha Thiem, Sarah Eisenacher, Andreas Meyer-Lindenberg, Mathias Zink
BACKGROUND: Depressive episodes in schizophrenia constitute a major clinical problem, and treatment success is often limited by treatment-emergent side effects. Agomelatine, an agonist at melatonergic MT1/MT2 receptors and 5-HT2C receptor antagonist, is a new antidepressant with a novel mode of action which constitutes a potential therapeutic option for depression in schizophrenia. METHODS: Twenty-seven patients with lifetime diagnoses within the schizophrenia spectrum and comorbid depression were treated with agomelatine in addition to stable doses of antipsychotic agents...
October 29, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27768670/quetiapine-extended-release-open-label-treatment-associated-changes-in-amygdala-activation-and-connectivity-in-anxious-depression-an-fmri-study
#7
Murat Altinay, Harish Karne, Erik Beall, Amit Anand
BACKGROUND: This study investigated extended release quetiapine (quetiapine XR) associated changes in functional MRI (fMRI) measures of task-induced amygdalar activation and resting state connectivity in anxious unipolar major depressive disorder (AMDD). METHODS: Anxious unipolar major depressive disorder patients (n = 15) (17-item Hamilton Depression Rating Scale (HAM-D) >18 and Hamilton Anxiety Scale (HAM-A) >18) and closely matched healthy control (HC) subjects were compared at baseline for task induced amygdala activation and resting state connectivity on fMRI...
October 21, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27755218/an-open-label-pilot-study-of-duloxetine-in-patients-with-irritable-bowel-syndrome-and-comorbid-major-depressive-disorder
#8
Roberto Lewis-Fernández, Peter Lam, Susan Lucak, Hanga Galfalvy, Elizabeth Jackson, Jane Fried, Melissa Rosario, Ana Alicia de la Cruz, Arturo Sánchez-Lacay, Samantha Díaz, Franklin Schneier
Major depressive disorder (MDD) and irritable bowel syndrome (IBS) frequently co-occur, yet treating their comorbid presentation is challenging. Low-dose tricyclic antidepressants are efficacious for IBS, but higher doses to treat depressive symptoms present tolerability problems, whereas selective serotonin reuptake inhibitors are more tolerable but show inconsistent efficacy for IBS. If efficacious, serotonin-norepinephrine reuptake inhibitors like duloxetine would provide a useful alternative. We explored efficacy, tolerability, and time to onset of action of duloxetine in comorbid IBS-MDD in an open-label, 12-week trial...
October 17, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27755217/anterior-cingulate-glutamate-is-reduced-by-acamprosate-treatment-in-patients-with-alcohol-dependence
#9
Mark A Frye, David J Hinton, Victor M Karpyak, Joanna M Biernacka, Lee J Gunderson, Scott E Feeder, Doo-Sup Choi, John D Port
Although the precise drug mechanism of action of acamprosate remains unclear, its antidipsotropic effect is mediated in part through glutamatergic neurotransmission. We evaluated the effect of 4 weeks of acamprosate treatment in a cohort of 13 subjects with alcohol dependence (confirmed by a structured interview, Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision) on proton magnetic resonance spectroscopy glutamate levels in the midline anterior cingulate cortex (MACC). We compared levels of metabolites with a group of 16 healthy controls...
October 17, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27755221/dihydroxyphenylglycol-as-a-biomarker-of-norepinephrine-transporter-inhibition-by-atomoxetine-human-model-to-assess-central-and-peripheral-effects-of-dosing
#10
Peter R Bieck, Mark Leibowitz, D Richard Lachno, Edouard Ledent, Robert Padich, Stan Jhee
To assess the primary metabolite of norepinephrine, 3,4-dihydroxyphenylglycol (DHPG), as a sensitive biomarker for norepinephrine transporter (NET) function and the relationship of DHPG measured peripherally and centrally, NET was antagonized with 80 mg/d atomoxetine for 18 days. Twelve healthy subjects were treated with atomoxetine in an open-label, multiple-dose exploratory study. Plasma atomoxetine reached steady state by day 6, and the pharmacokinetic results demonstrated availability of atomoxetine to the central nervous system...
October 15, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27753707/effect-of-fluoxetine-on-inflammatory-cytokines-in-drug-naive-major-depression-a-short-term-prospective-study-from-south-india
#11
Avin Muthuramalingam, Vikas Menon, Ravi Philip Rajkumar, Vir Singh Negi
No abstract text is available yet for this article.
October 6, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27753726/factors-associated-with-antidepressant-dosing-in-asia-findings-from-the-research-on-asian-psychotropic-prescription-study
#12
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J Tanra, Margarita Maramis, Winston Wu-Dien Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods...
October 5, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27749680/are-acceptance-and-skepticism-determinant-factors-for-adherence-to-drug-treatment-in-psychiatric-patients
#13
Carlos De Las Cuevas, Wenceslao Peñate, Casimiro Cabrera
No abstract text is available yet for this article.
October 4, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27749679/interaction-between-risperidone-venlafaxine-and-metronidazole-an-unknown-thread
#14
Jana Hovancakova, Georgios Schoretsanitis, Michael Grözinger, Gerhard Gründer, Michael Paulzen
No abstract text is available yet for this article.
October 4, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27749677/levofloxacin-associated-neuroexcitation
#15
Nida S F Husain, Paula Goldman, Kathryn Goldrath, Nasuh Malas
No abstract text is available yet for this article.
October 4, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27749676/tattooing-as-a-symptom-of-impulse-control-disorder-in-a-parkinsonian-patient-with-pramipexole
#16
David Maltête, Floriane Le Goff, Gulden Ozel, Romain Lefaucheur
No abstract text is available yet for this article.
October 4, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27749501/hypersalivation-as-an-adverse-drug-reaction-related-to-lithium-carbonate-a-case-report
#17
Rami Bou Khalil, Lama Souaiby, Roba Ghossan, Sami Richa
No abstract text is available yet for this article.
September 30, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27748724/atomoxetine-successfully-addresses-double-sphincteric-incontinence-in-a-child-with-attention-deficit-hyperactivity-disorder
#18
Ahmed Naguy
No abstract text is available yet for this article.
September 29, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27684292/statistics-commentary-series-commentary-no-17-validity
#19
David L Streiner
No abstract text is available yet for this article.
September 28, 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27680767/precipitation-of-carbamazepine-controlled-seizures-due-to-low-dose-risperidone-in-a-child-a-conspiracy-to-unbalance-blood-electrolytes
#20
Marco Pozzi, Roberta Pineschi, Paolo Bonanni, Alda Pellegri, Emilio Clementi
No abstract text is available yet for this article.
September 27, 2016: Journal of Clinical Psychopharmacology
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