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Journal of Clinical Psychopharmacology

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https://www.readbyqxmd.com/read/30113931/statistics-commentary-series-commentary-no-28-statistical-significance-and-replication
#1
David L Streiner, Geoffrey R Norman
No abstract text is available yet for this article.
August 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30113930/zero-eosinophil-count-as-a-predictor-of-clozapine-associated-late-onset-agranulocytosis-a-case-report
#2
Hui-Nien Yang, Pei-Shen Ho, Yu-Ting Tseng, Chih-Sung Liang
No abstract text is available yet for this article.
August 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30113929/monitoring-of-metabolic-cardiac-and-endocrine-indicators-in-youth-treated-with-antipsychotics-as-reported-by-health-care-professionals
#3
Lenneke Minjon, Els van den Ban, Emma de Jong, Toine C G Egberts, Eibert R Heerdink
BACKGROUND: It is unclear how youth treated with antipsychotics are monitored. The purpose of this study was to assess monitoring of metabolic, cardiac, and endocrine indicators in youth (<18 years old) treated with antipsychotics as reported by health care professionals in the Netherlands. METHODS: A questionnaire was designed to collect information from health care professionals regarding the monitoring of youth treated with antipsychotics. Data were collected at a national conference...
August 15, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30113354/the-role-of-c-reactive-protein-in-early-detection-of-myocarditis-associated-with-clozapine
#4
Christopher Mark Watson, Aneeka Alexander, Alexander Panickacheril John
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30113353/psychopharmacology-in-japan-an-overview-and-recent-topics
#5
Kazunari Yoshida, Takefumi Suzuki, Hiroyuki Uchida
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106885/erratum-updated-affiliation-for-two-articles-by-dr-lin-et-al
#6
(no author information available yet)
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106884/switching-from-tobacco-smoking-to-electronic-cigarettes-and-the-impact-on-clozapine-levels
#7
Thomas Kocar, Roland W Freudenmann, Manfred Spitzer, Heiko Graf
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106883/efficacy-of-sertraline-in-patients-with-major-depressive-disorder-naive-to-selective-serotonin-reuptake-inhibitors-a-10-week-randomized-multicenter-placebo-controlled-double-blind-academic-clinical-trial
#8
Roselin Valle-Cabrera, Yudexi Mendoza-Rodríguez, Maytee Robaina-García, Javier Ballesteros, Juan Rafael Cordero-Jiménez, Nadia B Espinosa-Rodríguez, Yenia Sotolongo-Garcia, Bianca Lauria-Horner
PURPOSE: The aim of this study was to assess the efficacy and safety of sertraline compared with placebo in a good clinical practice trial conducted with major depressive disorder patients naive to selective serotonin reuptake inhibitors. METHODS: This was a 10-week randomized, multicenter, placebo-controlled, double blind, superiority trial. Adult patients diagnosed with major depressive disorder (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria), total score of 19 to 36 in the 17-item Hamilton Depression Rating Scale (HAMD-17), were randomly allocated to sertraline (n = 39) or placebo (n = 38)...
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106882/salute-to-our-reviewers-2017-2018
#9
(no author information available yet)
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106881/tranylcypromine-plus-amitriptyline-for-electroconvulsive-therapy-resistant-depression-a-long-term-study
#10
Rafael Ferreira-Garcia, Rafael Christophe da Rocha Freire, José Carlos Appolinário, Michelle N Levitan, Roseane Dorte Halkjær-Lassen, João Romildo Bueno, Antonio E Nardi
BACKGROUND: Few therapeutic options are available for patients with electroconvulsive therapy-resistant major depressive disorder (ECT-r MDD), leaving a substantial proportion of this population beyond treatment possibilities. The combination of monoamine oxidase inhibitors and tricyclic antidepressants could be a potential strategy for managing ECT-r MDD, and the specific association of amitriptyline and tranylcypromine may offer additional tolerability advantages. Although promising, in our knowledge, no studies have examined until now the effectiveness of this combination in ECT-r MDD...
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106880/evaluating-the-effect-of-coenzyme-q10-augmentation-on-treatment-of-bipolar-depression-a-double-blind-controlled-clinical-trial
#11
Maryam Mehrpooya, Fatemeh Yasrebifar, Mohammad Haghighi, Younes Mohammadi, Leila Jahangard
BACKGROUND: Bipolar disorder (BPD) is a chronic and recurrent mood disorder characterized by episodes of mania, hypomania, and major depression. Based on available evidence, mitochondrial dysfunction, oxidative stress, and inflammation have important roles in the pathophysiology of bipolar depression. More specifically, it seems that coenzyme Q10 (CoQ10), a mitochondrial modulator, as well as an antioxidant and anti-inflammatory agent, might be effective in modulating these pathophysiological pathways...
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106879/treatment-of-risperidone-associated-hyperprolactinemia-with-aripiprazole
#12
Omar A Mazher, Eleni Maneta, William Hall
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106878/a-case-of-hypersexuality-probably-associated-with-lurasidone
#13
Balaswamy Reddy, Soumitra Das, Mustafa Ali
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106877/ineffectiveness-of-repeated-intravenous-ketamine-infusions-in-treatment-resistant-depression-after-a-post-ketamine-relapse-time-for-a-rethink
#14
Álvaro López-Díaz, José Luis Fernández-González
No abstract text is available yet for this article.
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30106876/the-effect-of-body-weight-changes-on-total-plasma-clozapine-concentrations-determined-by-applying-a-statistical-model-to-the-data-from-a-double-blind-trial
#15
Francisco J Diaz, Richard C Josiassen, Jose de Leon
PURPOSE/BACKGROUND: Some therapeutic drug monitoring studies suggest that increased weight is associated with small increases in clozapine concentrations. The goal of this study was to reanalyze a US double-blind study using a sophisticated statistical model to test whether weight gains from baseline or increases in percentage of body fat from baseline, computed from a published equation, are associated with increased total plasma clozapine concentrations after controlling for the effects of smoking and sex...
August 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30113352/can-we-improve-physical-health-monitoring-for-patients-taking-antipsychotics-on-a-mental-health-inpatient-unit
#16
Elyse Ross, Rebecca Barnett, Rebecca Tudhope, Kamini Vasudev
BACKGROUND: Patients with severe mental illness are at risk of medical complications, including cardiovascular disease, metabolic syndrome, and diabetes. Given this vulnerability, combined with metabolic risks of antipsychotics, physical health monitoring is critical. Inpatient admission is an opportunity to screen for medical comorbidities. Our objective was to improve the rates of physical health monitoring on an inpatient psychiatry unit through implementation of an electronic standardized order set...
August 13, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30102630/antipsychotic-use-and-the-risk-of-initiating-medication-for-benign-prostate-hyperplasia-in-persons-with-alzheimer-disease-a-matched-cohort-study
#17
Kim Orsel, Heidi Taipale, Sami Raatikainen, Pasi Lampela, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Helga Gardarsdottir, Sirpa Hartikainen
BACKGROUND: Antipsychotics (APs) are known to exacerbate symptoms of benign prostate hyperplasia (BPH) and may even cause urinary retention. The anticholinergic effects of APs and their dopamine D2- and α-receptor blockade may lead to voiding dysfunction of BPH patients. The objective of our study was to investigate whether the use of APs is associated with an increased risk of initiating medication for BPH in men with Alzheimer disease (AD). METHODS: Data from the nationwide MEDALZ (MEDication use and ALZheimer's disease) cohort, including all community-dwelling persons diagnosed with AD in Finland, were utilized...
August 10, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30102629/incidence-of-heart-failure-and-cardiomyopathy-following-initiation-of-medications-for-attention-deficit-hyperactivity-disorder-a-descriptive-study
#18
Andrew D Mosholder, Lockwood Taylor, Glenn Mannheim, Lisa Ortendahl, Tiffany S Woodworth, Sengwee Toh
PURPOSE/BACKGROUND: Stimulant abuse is associated with cardiomyopathy, but cardiomyopathy rates with therapeutic use of stimulants for attention-deficit/hyperactivity disorder (ADHD) are poorly characterized. Labels for methylphenidate, amphetamine, and atomoxetine caution against use in patients with cardiovascular disease. We sought to assess the incidence of new-onset heart failure or cardiomyopathy among initiators of these medications. METHODS/PROCEDURES: Using the Sentinel distributed database, we analyzed new-onset heart failure or cardiomyopathy among initiators of selected ADHD medications (amphetamine products including lisdexamfetamine, methylphenidate, and atomoxetine), by duration of use (0-90, 91-180, 181-270, 271-365, 366-730, and 731-1095 days) and age group (<22, 22-44, 45-64, and ≥65 years)...
August 10, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30102628/how-to-treat-hypertension-in-venlafaxine-medicated-patients-pharmacokinetic-considerations-in-prescribing-amlodipine-and-ramipril
#19
Marc Augustin, Georgios Schoretsanitis, Gerhard Gründer, Ekkehard Haen, Michael Paulzen
BACKGROUND: Amlodipine (AMLO) and ramipril (RAMI) belong to the most prescribed drugs in patients with hypertension, a condition also encountered in depression. Venlafaxine may worsen hypertension because of noradrenergic properties. Although of special clinical relevance, data on pharmacokinetic interactions between AMLO, RAMI, and venlafaxine (VEN) are lacking. METHODS: Two TDM databases consisting of plasma concentrations of VEN and its active metabolite O-desmethylvenlafaxine (ODVEN) were analyzed...
August 10, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/30102627/a-pilot-study-of-the-effectiveness-of-lithium-versus-quetiapine-immediate-release-monotherapy-in-patients-with-bipolar-spectrum-disorders
#20
Keming Gao, Toyomi Goto, Chengmei Yuan, Brittany Brownrigg, Carla Conroy, Philip K Chan, Mary Beth Serrano, Stephen J Ganocy, Fang Fang, Joseph R Calabrese
OBJECTIVE: The aim of this study was to compare the effectiveness of lithium versus quetiapine immediate release (IR) monotherapy in patients with bipolar I, II, or subthreshold bipolar disorder at any phase. METHODS: Eligible patients were randomized to lithium or quetiapine IR for 16 weeks. The difference in the time to discontinuation from study due to "all causes" between lithium and quetiapine IR groups and changes from baseline to 8 and 16 weeks in depression, mania, anxiety, quality of life (QOL), metabolic profiles, and proinflammatory markers were compared...
August 10, 2018: Journal of Clinical Psychopharmacology
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