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Journal of Applied Toxicology: JAT

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https://www.readbyqxmd.com/read/29350786/multiple-biological-defects-caused-by-calycosin-7-o-%C3%AE-d-glucoside-in-the-nematode-caenorhabditis-elegans-are-associated-with-the-activation-of-oxidative-damage
#1
Jianqin Zhang, Xiaoli Xue, Yang Yang, Wen Ma, Yan Han, Xuemei Qin
Calycosin-7-O-β-d-glucoside (CG) is an important active isoflavone compound in Radix Astragali that has many bioactivities. However, the toxicological effects and related toxicological mechanism of CG have been rarely documented. The purpose of the present study was to evaluate the toxicity effects of CG on the model organism Caenorhabditis elegans. Some characteristics of the nematode, including lifespan, movement behavior and reproductive capacity, were used to detect the toxic effects of CG on C. elegans...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29350773/effect-of-titanium-dioxide-nanoparticles-on-glucose-homeostasis-after-oral-administration
#2
Zhangjian Chen, Yun Wang, Xiang Wang, Lin Zhuo, Shi Chen, Shichuan Tang, Lin Zhao, Xianguo Luan, Guang Jia
As food additives, titanium dioxide nanoparticles (TiO2 NPs) have been widely used in various products that are usually simultaneously consumed with a high content of sugar, thus necessitating research on the effect of TiO2 NPs on glucose homeostasis. We conducted an animal study to explore the effect of orally administrated TiO2 NPs on glucose absorption and metabolism in rats at 0, 2, 10 and 50 mg kg-1 body weight day-1 for 30 and 90 days. The results showed that oral exposure to TiO2 NPs caused a slight and temporary hypoglycemic effect in rats at 30 days post-exposure but recovered at 90 days post-exposure...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29350772/arsenite-induced-histone-h3-modification-and-its-effects-on-egr1-and-fos-expression-in-hela-cells
#3
Toshihide Suzuki, Hiroshi Watanabe, Kayoko Kita, Taro Honma, Takafumi Ochi
It is evident that trivalent arsenicals do not have mutagenicity, but they are human carcinogens. Recently, epigenetic modification has been considered as one of the important causes of arsenical carcinogenicity. Here we examined global histone H3 modification by trivalent inorganic arsenite (iAs(III)) and its contribution to gene expression in HeLa cells. iAs(III) induced histone H3K9 dimethylation (H3K9me2) and trimethylation (H3K9me3), histone H3S10 phosphorylation (H3S10p), histone H3T11 phosphorylation (H3T11p) and histone H3K9S10 trimethyl-phosphorylation (H3K9me3S10p)...
January 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29341224/comparative-rna-seq-transcriptome-analysis-on-silica-induced-pulmonary-inflammation-and-fibrosis-in-mice-silicosis-model
#4
Jiayi Chen, Yuqin Yao, Xiaolan Su, Ying Shi, Xuejiao Song, Linshen Xie, Jia You, Liantian Tian, Luo Yang, Aiping Fang, Jingyuan Xiong
Silicosis is a long-established public health issue in developing countries due to increasingly serious air pollution and poorly implemented occupational safety regulation. Inhalation of silica triggers cytotoxicity, oxidative stress, pulmonary inflammation and eventually silicosis. Current understanding in the pathogenesis and mechanism of silicosis is limited, and no effective cure is clinically available once silicosis is developed. A number of studies were conducted to investigate silica-induced alternate gene expressions in pulmonary cells...
January 16, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29327353/increased-risk-of-congestive-heart-failure-in-patients-with-acetaminophen-poisoning-a-nationwide-cohort-study
#5
Wei-Sheng Chung, Cheng-Li Lin
Acetaminophen poisoning increases cytochrome P450 2E1 expression and reactive oxygen species production, which may lead to maladaptive myocardial remodeling and congestive heart failure (CHF). We conducted a nationwide cohort study to investigate the incidence and risk of CHF in patients with acetaminophen poisoning. We identified a cohort of adult patients with newly diagnosed acetaminophen poisoning in the inpatient claims of the Taiwan National Health Insurance Research Database for the 1998-2011 period...
January 11, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29315700/binding-affinity-and-decontamination-of-dermal-decontamination-gel-to-model-chemical-warfare-agent-simulants
#6
Yachao Cao, Akram Elmahdy, Hanjiang Zhu, Xiaoying Hui, Howard Maibach
Six chemical warfare agent simulants (trimethyl phosphate, dimethyl adipate, 2-chloroethyl methyl sulfide, diethyl adipate, chloroethyl phenyl sulfide and diethyl sebacate) were studied in in vitro human skin to explore relationship between dermal penetration/absorption and the mechanisms of simulant partitioning between stratum corneum (SC) and water as well as between dermal decontamination gel (DDGel) and water. Both binding affinity to and decontamination of simulants using DDGel were studied. Partition coefficients of six simulants between SC and water (Log PSC/w ) and between DDGel and water (Log PDDGel/w ) were determined...
January 7, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29297590/involvement-of-the-delayed-rectifier-outward-potassium-channel-kv2-1-in-methamphetamine-induced-neuronal-apoptosis-via-the-p38-mitogen-activated-protein-kinase-signaling-pathway
#7
Jingying Zhu, Songsong Zang, Xufeng Chen, Lei Jiang, Aihua Gu, Jie Cheng, Li Zhang, Jun Wang, Hang Xiao
Methamphetamine (Meth) is an illicit psychostimulant with high abuse potential and severe neurotoxicity. Recent studies have shown that dysfunctions in learning and memory induced by Meth may partially reveal the mechanisms of neuronal channelopathies. Kv2.1, the primary delayed rectifying potassium channel in neurons, is responsible for mediating apoptotic current surge. However, whether Kv2.1 is involved in Meth-mediated neural injury remains unknown. In the present study, the treatment of primary cultured hippocampal neurons with Meth indicated that Meth induced a time- and dose-dependent augmentation of Kv2...
January 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29297199/a-call-for-action-improve-reporting-of-research-studies-to-increase-the-scientific-basis-for-regulatory-decision-making
#8
Marlene Ågerstrand, Sofie Christiansen, Annika Hanberg, Christina Rudén, Lars Andersson, Sjur Andersen, Henrik Appelgren, Christine Bjørge, Ian Henning Clausen, Dag Markus Eide, Nanna B Hartmann, Trine Husøy, Halldór Pálmar Halldórsson, Marianne van der Hagen, Ellen Ingre-Khans, Adam David Lillicrap, Vibe Meister Beltoft, Anna-Karin Mörk, Mari Murtomaa-Hautala, Elsa Nielsen, Kristín Ólafsdóttir, Jaana Palomäki, Hinni Papponen, Emilie Marie Reiler, Helene Stockmann-Juvala, Tiina Suutari, Henrik Tyle, Anna Beronius
This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer-reviewed research studies in regulatory decision-making. Moreover, this could improve the reliability and reproducibility of published studies in general and make better use of the resources spent in research.
January 3, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29280155/nanosecond-pulsed-electric-field-incorporation-technique-to-predict-molecular-mechanisms-of-teratogenicity-and-developmental-toxicity-of-estradiol-17%C3%AE-on-medaka-embryos
#9
Akemi Yamaguchi, Hiroshi Ishibashi, Susumu Kono, Midori Iida, Masaya Uchida, Koji Arizono, Nobuaki Tominaga
Herein, we propose using a nanosecond pulsed electric field (nsPEF) technique to assess teratogenicity and embryonic developmental toxicity of estradiol-17β (E2 ) and predict the molecular mechanisms of teratogenicity and embryonic developmental defects caused by E2 on medaka (Oryzias latipes). The 5 hour post-fertilization embryos were exposed to co-treatment with 10 μm E2 and nsPEF for 2 hours and then continuously cultured under non-E2 and nsPEF conditions until hatching. Results documented that the time to hatching of embryos was significantly delayed in comparison to the control group and that typical abnormal embryo development, such as the delay of blood vessel formation, was observed...
December 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29277905/aryl-hydrocarbon-receptor-based-bioassays-for-dioxin-detection-thinking-outside-the-box
#10
REVIEW
Gaston Otarola, Hector Castillo, Sylvain Marcellini
Despite intensive media coverage and international regulations, man-made persistent organic pollutants such as dioxins represent a serious environmental and health threat. Their detection by sophisticated chromatography technologies is highly complex, impeding the constant monitoring of food or environmental samples. This limitation has fostered the development of generations of bioassays exploiting the molecular function of the aryl hydrocarbon receptor (AhR), which binds toxic compounds and directly activates the transcription of target genes...
December 26, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29277902/divergent-responsiveness-of-two-isoforms-of-the-estrogen-receptor-to-mixtures-of-contaminants-of-emerging-concern-in-four-vertebrates
#11
Satomi Kohno, Yoshinao Katsu, Nicholas Cipoletti, Lina C Wang, Zachary G Jorgenson, Shinichi Miyagawa, Heiko L Schoenfuss
Contaminants of emerging concern (CECs) are ubiquitous in aquatic environments with well-established endocrine-disrupting effects. A data matrix of 559 water samples was queried to identify two commonly occurring CECs mixtures in Great Lakes tributaries. One mixture consisted of eight agricultural CECs (AG), while another contained 11 urban CECs (UB). The known estrogenic compounds bisphenol A, estrone and nonylphenol were present in both mixtures. According to the EPA Tox21 in ToxCast database, AG and UB mixture at an environmentally relevant concentration were estimated to account for 6...
December 26, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29271492/early-life-exposure-to-tris-1-3-dichloroisopropyl-phosphate-induces-dose-dependent-suppression-of-sexual-behavior-in-male-rats
#12
Manami Kamishima, Tatsuya Hattori, Go Suzuki, Hidenori Matsukami, Chiaki Komine, Yasuyuki Horii, Gen Watanabe, Takumi Oti, Hirotaka Sakamoto, Tomoko Soga, Ishwar S Parhar, Yasuhiko Kondo, Hidetaka Takigami, Maiko Kawaguchi
Exposure to endocrine-disrupting chemicals may adversely affect animals, particularly during development. Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) is an organophosphate with anti-androgen function in vitro that is present in indoor dust at relatively high concentrations. In male rats, androgens are necessary for the development of reproductive organs, as well as the endocrine and central nervous systems. However, we currently do not know the exact effects of TDCIPP exposure through suckling on subsequent reproductive behavior in males...
December 22, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29250806/paraquat-and-mptp-alter-microrna-expression-profiles-and-downregulated-expression-of-mir-17-5p-contributes-to-pq-induced-dopaminergic-neurodegeneration
#13
Qingqing Wang, Yanting Zhan, Nan Ren, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan Li
Recent evidence indicates that microRNAs (miRNAs) play a key role in neurodegenerative diseases. However, the toxic effects of paraquat (PQ) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on miRNA expression profiles in dopaminergic neurons have not been investigated. In the present study, we used microarray analysis to show that PQ and MPTP induce alterations of miRNA expression in neuro-2a cells. The results reveal that treatment with 300 μm PQ caused miRNA deregulation, such that 60 miRNAs were upregulated and 228 miRNAs were downregulated...
December 18, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29250801/endocrine-disrupting-chemicals-4-nonylphenol-bisphenol-a-and-butyl-benzyl-phthalate-impair-metabolism-of-estradiol-in-male-and-female-rats-as-assessed-by-levels-of-15%C3%AE-hydroxyestrogens-and-catechol-estrogens-in-urine
#14
Madoka Nakagomi, Emako Suzuki, Yoshiaki Saito, Tetsuji Nagao
Bisphenol A (BPA), 4-nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine-disrupting chemicals, are known to mimic estrogen activity. The effects of these chemicals on 17β-estradiol (E2 ) metabolism in vivo in rats were examined. Male and female rats were given NP (250 mg kg-1  day-1 ), BPA (250 μg kg-1  day-1 ) or BBP (500 mg kg-1  day-1 ) by gavage for 14 days, followed by a single intraperitoneal injection of E2 (5 mg kg-1 ) on the final day. The urinary excretion over 72 hours of 2-hydroxyestrone 1-N-acetylcysteine thioether, 2-hydroxyestrone 4-N-acetylcysteine thioether, 4-hydroxyestrone 2-N-acetylcysteine thioether, 2-hydroxy-17β-estradiol (2-OHE2 ), 2-hydroxyestrone (2-OHE1 ), 4-hydroxy-17β-estradiol, 4-hydroxyestrone, 15α-hydroxyestriol (E4 ), 15α-hydroxy-17β-estradiol and 15α-hydroxyestrone was measured...
December 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29243275/in-vitro-toxicity-assessment-of-nanocrystals-in-tissue-type-cells-and-macrophage-cells
#15
Meiling Chen, Ying Li, Jiezhao Zhou, Zhenbo Yang, Zhiyuan Wang, Yang Yang, Hui Zhang, Zhiping Li, Xingguo Mei
Nanocrystals (NCs), a type of innovative material particle, are a potential drug delivery platform that aims to improve the bioavailability of hydrophobic drugs. However, due to the lack of consideration of their toxicity, existing studies have not investigated whether the nanoscale properties of NCs, such as particle sizes, may lead to NC-induced toxicity. Because of the disparity between the rapid development of NCs and the lack of studies regarding NC toxicity, the present study investigated possible NC toxicity and clarified the relationship between particle sizes and NC toxicity...
December 15, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29235125/nasal-epithelial-barrier-disruption-by-particulate-matter-%C3%A2-2-5-%C3%AE-m-via-tight-junction-protein-degradation
#16
Renwu Zhao, Zhiqiang Guo, Ruxin Zhang, Congrui Deng, Jian Xu, Weiyang Dong, Zhicong Hong, Hongzhi Yu, Huiru Situ, Chunhui Liu, Guoshun Zhuang
Upper airway diseases including sinonasal disorders may be caused by exposure to fine particulate matter (≤2.5 μm; PM2.5), as proven by epidemiological studies. PM2.5 is a complex entity whose chemical constituents and physicochemical properties are not confined to a single, independent "particle" but which in this study means a distinctive environmental "toxin." The mechanism whereby PM2.5 induces nasal epithelial barrier dysfunction leading to sinonasal pathology remains unknown. In the present study, human nasal epithelial cells were exposed to non-cytotoxic doses of PM2...
December 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29235124/silver-nanoparticles-increase-connexin43-mediated-gap-junctional-intercellular-communication-in-hacat-cells-through-activation-of-reactive-oxygen-species-and-mitogen-activated-protein-kinase-signal-pathway
#17
Yu Qin, Limin Han, Di Yang, Hongying Wei, Yue Liu, Junhui Xu, Herman Autrup, Furong Deng, Xinbiao Guo
Silver nanoparticles (AgNPs) are widely used in health and consumer products that routinely contact skin. However, the biological effects and possible mechanisms of AgNPs on skin remain unclear. Gap junctional intercellular communication (GJIC) plays a critical role in multicellular organisms to maintain tissue homeostasis. The aim of this study is to examine if non-coated AgNPs affect GJIC in human keratinocytes (HaCaT cells), and to identify the possible molecular mechanisms responsible for the effects. GJIC, connexin (Cx)43 protein and mRNA expression, and the effect of siRNA-mediated knockdown of Cx43 on GJIC were assessed...
December 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29226339/development-of-an-artificial-neural-network-model-for-risk-assessment-of-skin-sensitization-using-human-cell-line-activation-test-direct-peptide-reactivity-assay-keratinosens%C3%A2-and-in-silico-structure-alert-parameter
#18
Morihiko Hirota, Takao Ashikaga, Hirokazu Kouzuki
It is important to predict the potential of cosmetic ingredients to cause skin sensitization, and in accordance with the European Union cosmetic directive for the replacement of animal tests, several in vitro tests based on the adverse outcome pathway have been developed for hazard identification, such as the direct peptide reactivity assay, KeratinoSens™ and the human cell line activation test. Here, we describe the development of an artificial neural network (ANN) prediction model for skin sensitization risk assessment based on the integrated testing strategy concept, using direct peptide reactivity assay, KeratinoSens™, human cell line activation test and an in silico or structure alert parameter...
December 10, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29218775/comparative-proteomic-analysis-of-silver-nanoparticle-effects-in-human-liver-and-intestinal-cells
#19
Albert Braeuning, Axel Oberemm, Josephine Görte, Linda Böhmert, Sabine Juling, Alfonso Lampen
Consumers are orally exposed to nanoparticulate or soluble species of the non-essential element silver due to its use in food contact materials or as a food additive. Potential toxicity of silver nanoparticles has gained special scientific attention. A fraction of ingested ionic or particulate silver is taken up in the intestine and transported to the liver, where it may induce oxidative stress and elicit subsequent adverse responses. Here, we present a comprehensive analysis of global proteomic changes induced in human Hep G2 hepatocarcinoma cells by different concentrations of AgPURE silver nanoparticles or by corresponding concentrations of ionic silver...
December 7, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29205417/inhibition-of-germinal-vesicle-breakdown-in-xenopus-oocytes-in-vitro-by-a-series-of-substituted-glycol-ethers
#20
Douglas J Fort, Michael B Mathis, Patrick D Guiney, John A Weeks
A 24 hour in vitro Xenopus oocyte maturation (germinal vesicle breakdown [GVBD]) assay developed by Pickford and Morris (Environmental Health Perspectives, 1999, 107, 285-292) was used to screen a series of substituted glycol ethers (GEs). Substituted GEs included: ethylene glycol monomethyl ether (EGME); EG monoethyl ether (EGEE); EG monopropyl ether (EGPE); EG monobutyl ether (EGBE); EG monohexyl ether (EGHE); diethylene glycol monomethyl ether (DGME); triethylene glycol monomethyl ether (TGME); ethylene glycol monophenyl ether (EGPhE); EG monobenzyl ether (EGBeE); EG diphenyl ether (EGDPhE); and propylene glycol monophenyl ether (PGPhE)...
December 4, 2017: Journal of Applied Toxicology: JAT
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