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American Journal of Forensic Medicine and Pathology

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https://www.readbyqxmd.com/read/28085681/basal-ganglion-hemorrhage-as-delayed-complication-of-diethylene-glycol-ingestion
#1
Avneesh Gupta, Francisco J Diaz, Anita Lal, Lokman Sung, Cynthia K Aaron
Diethylene glycol (DEG), an organic compound (HOCH2CH2)2O is a commonly used solvent. Mass poisoning outbreaks have been reported because of frequent contaminations. A PubMed search for diethylene resulted in 795 publications with 151 specifically discussing the toxicity. Of the 151 reported toxicity reviews/case reports, only 6 publications discussed the long-term neurological effects of diethylene toxicity. We report a fatal case of oral ingestion of DEG with complications from delayed toxicity. She died 7 days after the second admission...
January 13, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28079530/can-intoxication-status-be-used-as-a-prediction-tool-for-manner-of-death-a-comparison-of-the-intoxication-status-in-violent-suicides-and-homicides
#2
D Kimberley Molina, Veronica M Hargrove
Determining the manner of death in medicolegal death investigations can be difficult. The investigator relies on many facets of death investigation, including the circumstances of death and autopsy examination. A study was designed to analyze whether the intoxication status of the decedent could be used as another tool in death investigations. The intoxication status of violent (nonoverdose or poisoning) suicides and homicides was retrospectively reviewed and compared. A total of 625 deaths were identified, including 366 suicides and 259 homicides...
January 10, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28072596/expression-of-glucose-regulated-protein-78-and-mir-199a-in-rat-brain-after-fatal-ligature-strangulation
#3
Xueying Feng, Dongchuan Zhang, Qingjin Gong, Zhiyong Zhang, Li Quan
The roles of endoplasmic reticulum (ER) stress and microRNA in the brain tissue after fatal mechanical asphyxia have not been clearly elucidated. We examined the expression of glucose-regulated protein 78 (GRP78), the key regulator of unfolded protein response, and miR-199a in the brain tissues of rats subjected to fatal ligature strangulation to understand the roles of ER stress and microRNA in ligature strangulation. The expressions of GRP78 and miR-199a in rat cortex, hippocampi, and midbrain were measured by immunohistochemistry and Western blot analysis in a rat model of ligature strangulation...
January 10, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28067671/a-fatal-case-of-coin-battery-ingestion-in-an-18-month-old-child-case-report-and-literature-review
#4
Francesco Ventura, Sara Candosin, Rosario Barranco, Alessandro Bonsignore, Luisa Andrello, Luca Tajana, Antonio Osculati
The ingestion of extraneous substances is quite common in clinical practice; it usually befalls in the pediatric age, mostly between 6 months and 6 years. In most cases, complications do not emerge, and the prognosis is considered favorable. However, when a case of battery ingestion occurs, serious adverse events may develop. The ingestion of these components is a potential life-threatening event for children.In this article, we report the case of an 18-month-old child who died from hemorrhagic shock due to an aortoesophageal fistula caused by a 20 mm lithium button battery lodged in the esophagus...
January 7, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28045696/sudden-death-in-a-male-infant-due-to-histiocytoid-cardiomyopathy-an-autopsy-case-and-review-of-the-literature
#5
Hanbing Xie, Xueqin Chen, Ni Chen, Qiao Zhou
Histiocytoid cardiomyopathy (HC) is a very rare cardiac disorder that mainly affects female infants younger than 2 years. It may manifest as ventricular tachycardia or dilated cardiomyopathy and frequently causes sudden death. The most common grossly change is multifocal uneven thickening of the endocardium, presenting a yellowish color, with some area forming nodular appearance, and histologically featured by scattered clusters of histiocytoid myocytes under the endocardium. Here, we present a 19-month-old male infant who died of heart failure, and an autopsy was performed and confirmed the diagnosis of HC...
December 30, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28045695/manner-of-death-determination-in-fire-fatalities-5-year-autopsy-data-of-istanbul-city
#6
İpek Esen Melez, Murat Nihat Arslan, Deniz Oguzhan Melez, Ahmet Selçuk Gürler, Yalçin Büyük
Death resulting from burns is an important social problem and a frequent accident. However, because approximately 10% of cases are estimated to result from a fire that was deliberately started, all fire-related deaths should be treated as suspicious, and the cause of a fire should be investigated. For the bodies recovered from the scene of a fire, the manner of death could also be suicide or homicide. The objective of this study was to contribute to the clarification of controversial data present in the literature on the manner of death determination of fire-related deaths, through evaluation of autopsy findings of bodies recovered from fires...
December 30, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28045694/forensic-analysis-of-parachute-deaths
#7
Michael Philip Burke, Johannes Chitty
Deaths associated with parachuting are very uncommon. However, these deaths do tend to be "high profile" in the traditional and social media. When forensic pathologists examine the deceased after a fatal parachuting incident, the anatomical cause of death is usually not in question. For most forensic pathologists, it is usually the case that we will have very limited knowledge of parachuting equipment or the mechanics of a typical successful parachute jump. As such, the investigation of the death should involve a multidisciplinary approach with an appropriate expert providing the formal forensic examination of the parachuting equipment...
December 30, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28045743/role-of-survival-time-and-injury-severity-in-fatal-pulmonary-fat-embolism
#8
Juliane Jarmer, Garyfalia Ampanozi, Michael J Thali, Stephan A Bolliger
Pulmonary fat embolism (PFE) is frequent in blunt trauma and may occasionally lead to death. A correlation between fracture grade and severity and PFE grade has been described before, but no correlation between PFE and survival time, fat crushing extent, fat crush grade, or number of body regions with fractures could be noted in this small study. To further examine this, we decided to examine the aforementioned points in a far larger study group.Autopsy protocols of 188 nonresuscitated fatalities with blunt trauma and without right heart injury, which underwent whole body dissection, were retrospectively reviewed concerning the presence and the severity of PFE, injuries, survival time, age, sex, and the body mass index...
December 29, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28009598/streptococcus-pneumoniae-detection-long-time-after-death-in-a-fatal-case-of-waterhouse-friderichsen-syndrome
#9
Andrea Verzeletti, Carlo Bonfanti, Anna Leide, Elena Azzalini, Maria Antonia De Francesco, Giorgio Piccinelli, Francesco De Ferrari
We report a fatal case of Waterhouse-Friderichsen syndrome in a 64-year-old man. The diagnosis, suspected during the autopsy (performed 63 hours after death), was confirmed through the successful detection of Streptococcus pneumoniae DNA and antigens in samples (blood and liver) collected during the autopsy. These results conformed with blood cultures performed antemortem, which became available only the day after the autopsy. The case underlines the need to collect biological material (liver and blood samples) during autopsy for microbiological investigations, although the collection is performed a long time after the death, suggesting that a liver sample works for DNA and liver and blood work for Streptococcus pneumoniae antigen detection...
December 22, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28005586/sudden-death-from-ruptured-intracranial-vascular-malformations-during-mechanical-asphyxia-a-domestic-violence-case-report
#10
Xue-Mei Wu, Xu-Dong Zhang, Li-Bing Yun, Min Liu, Xu-Fu Yi
Smothering and manual strangulation are not uncommon in domestic violence against women; however, no report on the combination of mechanical asphyxia and intracranial vascular malformations has been previously published. We report a middle-aged woman who was smothered and manually strangled by her husband and subsequently died from subarachnoid hemorrhage due to ruptured intracranial vascular malformations, rather than direct mechanical asphyxiation. Smothering and manual strangulation are considered provocative conditions for rupture and contributory causes of death...
December 21, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28005585/penicillin-induced-fulminant-myocarditis-a-case-report-and-review-of-the-literature
#11
Mehdi Ben Khelil, Youssef Chkirbene, Mona Mlika, Slim Haouet, Moncef Hamdoun
Drug-induced eosinophilic myocarditis is uncommon with few cases reported in the literature. It is a rare but potentially life-threatening disease.We report the case of an 11-year-old girl without medical history who developed an acute malaise and chills, followed by severe shortness of breath and a cardiopulmonary arrest 1 hour after an intramuscular injection of penicillin.At autopsy, we observed in the external examination nonspecific asphyxia signs, an injection mark, and the absence of traumatic signs...
December 21, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28005584/postmortem-increase-in-body-core-temperature-how-inaccurate-we-can-be-in-time-since-death-calculations
#12
Tomáš Vojtíšek, Štěpánka Kučerová, Jan Krajsa, Bülent Eren, Petra Vysočanová, Petr Hejna
Postmortem increase in body core temperature is a well-known phenomenon in forensic practice. Despite this, cases of reliably documented postmortem hyperthermia are rarely reported in the forensic literature, and it is still not clear how frequently postmortem hyperthermia occurs and in which cases we may it predict. In routine forensic practice, the standard course of body cooling is expected, and the prediction of normal body core temperature in the time of death is used for back-calculating the time of death by Henssge method...
December 21, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28005583/the-virtual-hydrostatic-test
#13
Edward L Mazuchowski, Dori M Franco, Philip J Berran, H Theodore Harcke
The hydrostatic test is used to help determine if there has been a live birth. Computed tomography (CT), with its ability to detect and localize air/gas in the body, offers a rapid, noninvasive tool for assessment.Four baby deaths (20 to 25 weeks' gestation) in which the hydrostatic test, radiographs, and CT were performed before autopsy are presented. In 2 cases, considered stillbirths, the lungs and liver sank, and there was no air seen in the lungs or gas in the liver on CT. Histology of the lungs showed collapsed alveoli...
December 21, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28002071/occupational-hydrogen-sulfide-fatalities-and-thiosulfate-levels
#14
Stephanie Sayre Smith, Dawn L Cannon, Kathleen Fagan, Christopher P Weis
No abstract text is available yet for this article.
December 20, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27906701/child-sexual-abuse-confirmed-by-forensic-examination-in-salvador-bahia-brazil
#15
Welington Dos Santos Silva, Ubirajara de Oliveira Barroso-Junior
Child sexual abuse is a worldwide public health issue. The objective of this study was to describe the demographic and clinical characteristics of children in cases of sexual abuse confirmed by material evidence at forensic examination. Cases of children younger than 12 years examined for suspected sexual abuse at the Institute of Forensic Medicine in Salvador, Bahia, Brazil, were reviewed retrospectively. The period evaluated was between 2005 and 2010. The inclusion criterion was the coroner's confirmation of sexual abuse based on material evidence...
November 30, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27879497/the-differential-diagnosis-between-natural-death-and-homicide-an-everlasting-challenge-for-the-forensic-pathologist-an-exemplar-case-report
#16
Alessandro di Luca, Valentino de Matteis, Antonio Marcelli, Matteo Polacco, Vincenzo L Pascali, Antonio Oliva
Most of the work performed by the forensic expert is to find proof for different plausible hypotheses that may be used in a trial to serve justice purposes when the "identity" of a case is already unveiled. Yet the previous phase of the investigation is also of great importance, and sometimes (like in the presented case), it represents the core element of the entire investigation. The appropriate determination of the differential diagnosis between a natural death and a death of forensic interest (ie, homicide) is the first and crucial step in the classification of a case...
November 23, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27879496/death-due-to-pulmonary-alveolar-proteinosis
#17
Emran Altaf, Erik K Mitchel, Chris Berry, Altaf Hossain
Presented are 2 cases of death from pulmonary alveolar proteinosis (PAP). Within the past 2 years, there have been 2 cases of rare nonneoplastic lung disease that consists of the filling of the alveoli of the lung by a periodic acid-Schiff stain-positive lipoproteinaceous material. This condition bears a certain resemblance to interstitial lung disease and/or Pneumocystitis jirovecci infection of the lungs. The presented cases were clinically diagnosed as interstitial lung disease. In the first case presented, the decedent was admitted to hospital with diagnosis of pneumonia but died in hospital despite observation and treatment...
November 23, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27861172/liver-subcapsular-hematoma-a-rare-cause-of-sudden-unexpected-death
#18
Dorra Oualha, Abir Aissaoui, Meriam Belhaj, Mohamed Amin Mesrati, Adnene Moussa, Nidhal Haj Salem, Abdelfateh Zakhama, Ali Chadly
The spontaneous subcapsular hematoma of the liver is very rare. There are only a few reported cases in the literature.Most reported cases of liver hematoma often occur during pregnancy as part of the hemolysis, elevated liver enzymes, and low platelet count syndrome. The other causes may be due to amylosis, rupture of hepatocellular carcinoma, adenoma, focal nodular hyperplasia, hemorrhagic cyst, or hemopathy. Idiopathic spontaneous subscapular hematoma is a rare and often fatal condition.We report a case of a 43-year-old woman having Steinert disease who died because of a fatal spontaneous liver hemorrhage occurring without any traumatism...
November 17, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27831943/a-unusual-lightning-death-in-an-indoor-setting-a-case-report
#19
Francesco Ventura, Rosario Barranco, Alessandro Bonsignore, Francesco De Stefano
Death due to lightning strikes is infrequent, above all indoors. Some cases may take on a medical legal interest due to the unusual and uncommon circumstances in which they occur. The authors report an extremely rare case of electrocution occurred inside a house in a rural area. A 53-year-old man was reached by an electrical discharge originating from lightning while he was doing renovation work on a cottage. In this case, the correct interpretation of the autopsy and histological aspects and the attentive analysis of the circumstantial and environmental data led to the correct diagnosis of death and to the reconstruction of the dynamics with which it occurred...
November 9, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27973393/sudden-cardiac-death-autopsy-findings-in-7200-cases-between-2001-and-2015
#20
Petru Ifteni, Barna Barabas, Claudia Gavris, Marius Moga, Victoria Burtea, Laura Dracea
BACKGROUND: Sudden cardiac death (SCD) is a sudden unexpected event, from a cardiac cause, that occurs in less than 1 hour after the symptom onset in a person without any previous condition that would seem fatal or who was seen without any symptoms 24 hours before being found dead. OBJECTIVE: The aims of the study were to describe the features of SCD in Brasov County, Romania (400,000 inhabitants) according to local forensic department autopsy files. METHODS: We retrospectively chart reviewed a number of 7200 autopsy reports between 2001 and 2015 to identify cases of SCD...
November 4, 2016: American Journal of Forensic Medicine and Pathology
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