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Journal of Andrology

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https://www.readbyqxmd.com/read/22879532/special-section-commemorating-the-journal-of-andrology-s-distinguished-history
#1
EDITORIAL
Arthur L Bud Burnett, Sally P Darney, Jay Sandlow
No abstract text is available yet for this article.
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879531/parting-messages-from-current-and-former-editors-of-the-journal-of-andrology
#2
EDITORIAL
Andrzej Bartke, Marie-Claire Orgebin-Crist, Claude Desjardins, Ron Lewis, Don Tindall, David W Hamilton, Jon L Pryor, Peter N Schlegel, Matthew P Hardy, Arthur L Bud Burnett, Sally P Darney, Jay Sandlow
The proposal to produce this final commemorative issue for the Journal of Andrology arose during our regular discussions as current editors soon after it was announced that the Journal would complete its own life course and merge into a new publication (to be named Andrology) with the International Journal of Andrology. We considered the momentous occasion to be one that should be celebrated with an enduring tribute in recognition of the Journal's exceptional 33-year existence. Among the various contributions sought for inclusion in this issue, we envisioned an article assembling collected short essays from all living former editors drawing on notable events and highlights, if not less well-known challenges and successes arising during their editorship eras...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879530/evolution-of-the-journal-of-andrology-and-a-bright-future-for-andrology
#3
EDITORIAL
Marvin L Meistrich, Douglas T Carrell
No abstract text is available yet for this article.
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879529/management-of-erectile-dysfunction-great-progress-greater-promise
#4
REVIEW
Arthur L Burnett, Wayne J G Hellstrom
Sexual medicine, exemplified by the management of erectile dysfunction, is a traditional pillar of andrology. Erectile dysfunction has received the greatest attention within the specialty area and its management models the progress of the field more generally. This review provides a perspective of the history and contemporary practice of erectile dysfunction management, highlighting aspects of basic science research, epidemiology, and clinical care. Furthermore, the impact of this field as a major health concern in correlation with basic aspects of wellness and disease is acknowledged...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879528/aging-and-declining-testosterone-past-present-and-hopes-for-the-future
#5
REVIEW
Barry R Zirkin, Joyce Lisa Tenover
As men age, serum testosterone (T) levels decline, whereas serum luteinizing hormone (LH) levels increase somewhat or remain unchanged. Age-related reductions in T levels may be associated with alterations in body composition; energy level; muscle strength; physical, sexual, and cognitive functions; and mood. The predominant contributor to the decline in serum T levels is the decreased ability of the aging testes to make T. As in humans, the Brown Norway rat demonstrates age-related reductions in serum T levels in the setting of unchanged or modestly increased serum LH levels...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879527/the-genetics-of-male-fertility-from-basic-science-to-clinical-evaluation
#6
REVIEW
Alexander W Pastuszak, Dolores J Lamb
Our understanding of male fertility has increased dramatically over the past several decades, in large part because of advances in technology and the ability to rapidly analyze large quantities of high-resolution genetic data. These research efforts have led to an understanding of some of the genes involved in male fertility and have enabled us to test for defects in these genes that result in infertility in men. However, our understanding of male fertility remains far from comprehensive, and many genes involved in male fertility likely remain to be identified and their mechanisms of action elucidated...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879526/questions-about-spermatogonia-posed-and-answered-since-2000
#7
REVIEW
Dirk G de Rooij, Michael D Griswold
This review focuses on 3 important advances in our understanding of rodent spermatogonial stem cells (SSC) that have emerged since 2000: the identity of SSC, the existence of a SSC niche, and gene expression in spermatogonia. It is now apparent that the original scheme, in which the A(single) (A(s)) spermatogonia are the only stem cells, may be too simple. Rather, separation of pairs of A(paired) (A(pr)) spermatogonia into singles might also play a role in the steady state situation. However, evidence that in the normal epithelium fragmentation of chains of A(aligned) (A(al)) spermatogonia into smaller clones also plays a role is not yet conclusive...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22879525/reactive-oxygen-species-and-sperm-function-in-sickness-and-in-health
#8
REVIEW
R John Aitken, Keith T Jones, Sarah A Robertson
The ability of spermatozoa to generate reactive oxygen species (ROS) has been appreciated since the 1940s. It is a universal property of mature spermatozoa from all mammalian species and a major contributor to the oxidative stress responsible for defective sperm function. The mechanisms by which oxidative stress limits the functional competence of mammalian spermatozoa involve the peroxidation of lipids, the induction of oxidative DNA damage, and the formation of protein adducts. ROS production in these cells involves electron leakage from the sperm mitochondria, triggered by a multitude of factors that impede electron flow along the electron transport chain...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22837112/the-semen-quality-of-1158-men-with-testicular-cancer-at-the-time-of-cryopreservation-results-of-the-french-national-cecos-network
#9
Nathalie Rives, Anne Perdrix, Sylviane Hennebicq, Jacqueline Saïas-Magnan, Marie-Claude Melin, Isabelle Berthaut, Claire Barthélémy, Myriam Daudin, Ethel Szerman, Jean-Luc Bresson, Florence Brugnon, Louis Bujan
Testicular cancer is the most common cancer in young men. Several studies have reported an alteration in semen quality in nonseminoma tumors, but this result has not been confirmed in all of the published data. We performed a retrospective study in a population of 1158 men with testicular cancer who banked sperm between 1999 and 2003 in 11 French Centre d'Etude et de Conservation des Oeufs et du Sperme humain laboratories. Our study evaluated prefreeze and postthaw sperm parameters according to patient medical history, tumor histological type, and disease stage...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22790645/dietary-fat-modulates-the-testosterone-pharmacokinetics-of-a-new-self-emulsifying-formulation-of-oral-testosterone-undecanoate-in-hypogonadal-men
#10
RANDOMIZED CONTROLLED TRIAL
Anthony Yin, Eman Alfadhli, Michelle Htun, Robert Dudley, Sandra Faulkner, Laura Hull, Andrew Leung, Rachelle Bross, James Longstreth, Ronald Swerdloff, Christina Wang
This study investigates the effect of dietary fat on the testosterone (T) pharmacokinetics in hypogonadal men following administration of a self-emulsifying capsule formulation of oral T undecanoate (TU). In an open-label, 2-center, 5-way crossover study, a single oral dose of TU containing 300-mg equivalents of T (maximum anticipated human dose per administration) was administered to 16 hypogonadal men with a washout period of at least 5 days between doses. All participants were randomized to receive the TU capsules fasting or 30 minutes after an approximately 800-calorie meal containing 10%, 20%, 30%, or 50% fat...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22790644/effects-of-castration-and-late-hormonal-replacement-in-the-structure-of-rat-corpora-cavernosa
#11
Alexandre F Miranda, Carla B M Gallo, Diogo B De Souza, Waldemar S Costa, Francisco J B Sampaio
The objective of the study was to evaluate, through quantitative methods, the structural alterations in the corpora cavernosa of rats submitted to orchiectomy as well as the role of late hormone replacement in overturning the possible structural alterations. Twenty-five male rats were assigned into 5 groups with 5 animals each and treated as follows: ORCHIEC-1 = submitted to orchiectomy and sacrificed after 1 month; C-1 = control group sacrificed after 1 month; ORCHIEC-2 = submitted to orchiectomy and sacrificed after 2 months; C-2 = control group sacrificed after 2 months; and T = submitted to orchiectomy, underwent testosterone replacement with testosterone undecanoate (100 mg/kg) after 1 month, and sacrificed after 1 month of hormonal replacement...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22790643/seasonal-fluctuations-in-testosterone-estrogen-ratio-in-men-from-the-southwest-united-states
#12
Daniel J Moskovic, Michael L Eisenberg, Larry I Lipshultz
Although controversial, seasonal variations in testosterone have been observed in several populations of men throughout the world. This finding might have an impact on screening and treatment of hypogonadism. We examined the circannual patterns of sex hormones in the Southwest United States. A prospectively assembled database of almost 11 000 patients in a men's health practice was used to collect data on testosterone, estradiol, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and dehydroepiandrosterone-sulfate (DHEA-S)...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22790642/effects-of-once-daily-tadalafil-on-treatment-satisfaction-psychosocial-outcomes-spontaneous-erections-and-measures-of-endothelial-function-in-men-with-erectile-dysfunction-but-naive-to-phosphodiesterase-type-5-inhibitors
#13
RANDOMIZED CONTROLLED TRIAL
Hartmut Porst, Gerald B Brock, Krzysztof Kula, Ignacio Moncada, Francesco Montorsi, Bruce R Basson, Kraig Kinchen, Antonio Aversa
Previous studies established the efficacy of once-daily tadalafil for men with erectile dysfunction. However, no trial has focused on the effects of such treatment on men without previous experience using oral phosphodiesterase type 5 inhibitors. Patients were randomized (2:1) to once-daily tadalafil 5 mg (with possible down-titration to 2.5 mg; n = 146) or placebo (n = 69) for 12 weeks. Among 215 patients (mean age, 52 years), once-daily tadalafil treatment resulted in 61.7% of study participants reporting their ability to achieve and maintain erections as being much better or very much better (vs 21...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22744864/sexual-dysfunction-following-radical-prostatectomy
#14
REVIEW
Cooper R Benson, Ege Can Serefoglu, Wayne J G Hellstrom
Prostate cancer is the most common solid cancer in men and the second leading cause of cancer death in men. A favored treatment option for organ-confined prostate cancer in a middle-aged healthy man is radical prostatectomy (RP). Despite advances in techniques for RP, there remain concerns among physicians and patients alike on its adverse effects on sexual function. Although post-RP erectile dysfunction has been extensively studied, little attention has been focused on the other domains of sexual function, namely loss of libido, ejaculatory dysfunction, orgasmic dysfunction, penile shortening, and Peyronie disease...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22744863/prognostic-factors-in-chinese-patients-with-penile-invasive-squamous-cell-carcinoma
#15
Xiaopeng Chen, Xuesong Li, Maurice M Garcia, Kan Gong, Yi Song, Zhisong He, Liqun Zhou
The incidence of penile cancer varies by ethnicity and is not well described among Chinese patients. We performed a retrospective study to assess the prognostic factors in Chinese patients with penile invasive squamous cell carcinoma (SCC). We reviewed the medical records of 83 consecutive patients treated at the National Urological Cancer Center (Beijing, China). The Kaplan-Meier method, log-rank test, and multivariate Cox proportional hazard model were used to identify the prognostic factors predicting for cancer-specific survival (CSS)...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22700765/dr-claude-gagnon
#16
Cristian O'Flaherty, Eve de Lamirande, Pierre Leclerc, Linda Lefievre, Bernard Robaire
No abstract text is available yet for this article.
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22700764/cryopreservation-of-human-spermatozoa-decreases-the-number-of-motile-normal-spermatozoa-induces-nuclear-vacuolization-and-chromatin-decondensation
#17
Florence Boitrelle, Martine Albert, Claire Theillac, Fatma Ferfouri, Marianne Bergere, François Vialard, Robert Wainer, Marc Bailly, Jacqueline Selva
Even though cryopreservation of human spermatozoa is known to alter sperm motility and viability, it may also induce nuclear damages. The present study set out to determine whether or not cryopreservation alters motile sperm morphology under high magnification and/or is associated with chromatin decondensation. For 25 infertile men, we used high-magnification microscopy to determine the proportions of various types of motile spermatozoa before and after freezing-thawing: morphometrically normal spermatozoa with no vacuole (grade I), ≤ 2 small vacuoles (grade II), at least 1 large vacuole or >2 small vacuoles (grade III), and morphometrically abnormal spermatozoa (grade IV)...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22700763/priapism-as-the-initial-manifestation-of-a-penile-and-lower-limb-cutaneous-metastasis-of-prostate-adenocarcinoma-with-low-serum-psa-level
#18
Dalin He, Jin Zeng, Xudong Li, Kaijie Wu, Dapeng Wu, Hui He, Wenbin Song, Lei Li
Penile and/or cutaneous metastases from prostate adenocarcinoma rarely occur. Here, we detail the case of a 78-year-old man suffering from priapism caused by metastatic prostate cancer with both penile and lower limb cutaneous spread. His serum prostate-specific antigen level was 0.09 μg/L when priapism developed. Corpora cavernosa biopsy was refused by the patient and radical penectomy was performed. Postoperative pathologic and immunohistochemical studies revealed undifferentiated prostate adenocarcinoma cells growing in corpora cavernosa...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22700762/antiandrogenic-activity-of-resveratrol-analogs-in-prostate-cancer-lncap-cells
#19
Kazuhiro Iguchi, Tomoaki Toyama, Tetsuro Ito, Toshinobu Shakui, Shigeyuki Usui, Masayoshi Oyama, Munekazu Iinuma, Kazuyuki Hirano
The suppression of androgen signaling is a therapeutic target for the treatment of prostate cancer. Resveratrol (3,4',5-trihydroxystilbene) is known to inhibit the function of the androgen receptor (AR). In the present study, we investigated the antiandrogenic activities of resveratrol analogs in order to identify a potent antiandrogen compound. Resveratrol analogs were isolated from plants or were semisynthesized from resveratrol. AR transcriptional activity was measured in prostate cancer LNCaP cells using a luciferase assay with the MMTV-luc reporter plasmid...
November 2012: Journal of Andrology
https://www.readbyqxmd.com/read/22700761/highly-active-antiretroviral-therapy-haart-and-testicular-morphology-current-status-and-a-case-for-a-stereologic-approach
#20
REVIEW
Onyemaechi O Azu
As antiretroviral therapy becomes increasingly accessible, the associated improvements in the health, quality of life, and survival of patients are anticipated to influence the fertility determinants of patients, specifically young males, within the reproductive axis. Therefore, the understanding of testicular histology in patients with HIV/AIDS undergoing therapeutic management is essential, because the sexual route is one of the main means of transmission of HIV, which is localized primarily in the germ cells of the testes...
November 2012: Journal of Andrology
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