Domenico Milardi, Giuseppe Grande, Antonella Giampietro, Francesca Vendittelli, Sara Palumbo, Linda Tartaglione, Riccardo Marana, Alfredo Pontecorvi, Laura de Marinis, Cecilia Zuppi, Ettore Capoluongo
Testosterone deficiency has become a frequently diagnosed condition in today's society affected by epidemic obesity, and is associated with cardiovascular risk. Recent studies have established the importance of altered vascular endothelium function in cardiovascular disease. The damage to the endothelium might also cause endothelial cell detachment, resulting in increased numbers of circulating endothelial cells (CEC) within the bloodstream. To evaluate whether hypogonadism could modify CEC count in peripheral bloodstream, we investigated peripheral blood CEC count using the CellSearch System, a semiautomatic method to accurately and reliably enumerate CECs, which are sorted based on a CD146(+), CD105(+), DAPI(+), CD45(-) phenotype, in a population of 20 patients with hypogonadism...
November 2012: Journal of Andrology