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Iranian Journal of Medical Sciences

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https://www.readbyqxmd.com/read/29749994/simultaneous-presence-of-macular-corneal-dystrophy-and-retinitis-pigmentosa-in-three-members-of-a-family
#1
Farhad Nejat, Hossein Aghamollaei, Shiva Pirhadi, Khosrow Jadidi, Mohammad Amin Nejat
Macular corneal dystrophy (MCD) is an autosomal recessive hereditary disease. In most cases, various mutations in carbohydrate sulfotransferase 6 (CHST6) gene are the main cause of MCD. These mutations lead to a defect in keratan sulfate synthesis. Retinitis pigmentosa (RP) is another eye disorder with nyctalopia as its common symptom. It has been shown that more than 65 genes have been implicated in different forms of RP. Herein, we report on a 9-member family with 2 girls and 5 boys. Both parents, one of the girls and one of the boys had normal eye vision and another boy had keratoconus...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749993/central-acinic-cell-carcinoma-of-the-mandible-simulating-as-benign-odontogenic-lesion-a-case-report
#2
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749992/a-new-mutation-causing-severe-infantile-onset-pompe-disease-responsive-to-enzyme-replacement-therapy
#3
Hossein Moravej, Anis Amirhakimi, Alireza Showraki, Hamid Amoozgar, Zahra Hadipour, Ghasem Nikfar
Pompe disease (PD), also known as "glycogen storage disease type II (OMIM # 232300)" is a rare autosomal recessive disorder characterized by progressive glycogen accumulation in cellular lysosomes. It ultimately leads to cellular damage. Infantile-onset Pompe disease (IOPD) is the most severe type of this disease and is characterized by severe hypertrophic cardiomyopathy and generalized hypotonia. Mutations in the acid alpha-glucosidase ( GAA ) gene, located at locus 17q25.3, are responsible for the disease leading to reduced activity of the acid alpha-glucosidase enzyme...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749991/pulmonary-embolism-as-a-rare-complication-of-liver-hydatid-cyst-report-of-two-cases
#4
Omar Toumi, Randa Salem, Sadok Ben Jabra, Ghedira Abdesslem, Faouzi Noomen, Abdel Aziz Hamdi
Hydatid cyst is a helminth infection. The rupture of a hepatic hydatid cyst in inferior vena cava is a rare and lethal complication. Pulmonary embolism is the commonest manifestation. The diagnosis of hydatid cyst is made by histopathological or serological examination, and imaging may suggest the probability of hydatid cyst. Surgical treatment should be performed with caution and always under vascular control. We present two cases of hydatid cyst ruptured into the inferior vena cava. The patients also presented with dyspnea, hemoptysis, and intermittent cough at the time of admission...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749990/optimization-of-the-static-human-osteoblast-osteoclast-co-culture-system
#5
James Jam Jolly, Kok-Yong Chin, Mohd Fozi Nur Farhana, Ekram Alias, Kien Hui Chua, Wan Nuraini Wan Hasan, Soelaiman Ima-Nirwana
Osteoblasts (OBs) and osteoclasts (OCs) are 2 major groups of bone cells. Their cell-to-cell interactions are important to ensure the continuity of the bone-remodeling process. Therefore, the present study was carried out to optimize an OB/OC co-culture system utilizing the human OB cell line hFOB 1.19 and OCs extracted from peripheral blood mononuclear cells (PBMNCs). It was a 2-step procedure, involving the optimization of the OB culture and the co-culture of the OBs with PBMNCs at an optimum ratio. Firstly, pre-OBs were cultured to 90% confluency and the time required for differentiation was determined...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749989/first-report-on-the-percentiles-of-the-glomerular-filtration-rate-in-iranian-children-using-the-2009-schwartz-equations
#6
Peyman Roomizadeh, Alaleh Gheissari, Roya Kelishadi, Farhad Mahmoudi, Amin Abedini
The glomerular filtration rate (GFR) is widely considered the best overall index of renal function. The Schwartz equations are designed for measuring the GFR in children between 1 and 16 years of age. In the present study, we investigated the percentiles of the GFR in a general population of Iranian children with no known renal disease via the 2009 Schwartz equations (updated and combined equations). Between 2010 and 2011, we selected 687 children aged 7-16 years from the Iranian province of Isfahan. Blood samples were analyzed for blood urea nitrogen, creatinine, and cystatin C...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749988/amelioration-of-pentylenetetrazole-induced-seizures-by-modulators-of-sigma-n-methyl-d-aspartate-and-ryanodine-receptors-in-mice
#7
Mojtaba Keshavarz, Behdad Yekzaman
Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods: PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8)...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749987/the-preventive-role-of-pioglitazone-in-glycerol-induced-acute-kidney-injury-in-rats-during-two-different-treatment-periods
#8
Rama Mousleh, Shaza Al Laham, Ahmad Al-Manadili
Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period. Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days)...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749986/-urtica-dioica-distillate-regenerates-pancreatic-beta-cells-in-streptozotocin-induced-diabetic-rats
#9
Ali Gohari, Ali Noorafshan, Masoumeh Akmali, Fahimeh Zamani-Garmsiri, Atefeh Seghatoleslam
Background: Urtica dioica is known as an anti-hyperglycemic plant. Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as "aragh gazaneh". In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for the recovery from diabetes by determining the serum insulin, blood glucose, volume of pancreatic islets, and the number and volume of β-cells in diabetic rats...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749985/hyperuricemia-induces-wnt5a-ror2-gene-expression-epithelial-mesenchymal-transition-and-kidney-tubular-injury-in-mice
#10
Wiwit Ananda Wahyu Setyaningsih, Nur Arfian, Efrayim Suryadi, Muhammad Mansyur Romi, Untung Tranggono, Dwi Cahyani Ratna Sari
Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial-mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury. Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old, 30-40 g) with daily intraperitoneal injections of 125 mg/kg body weight (BW) of uric acid...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749984/the-effects-of-size-and-type-of-vocal-fold-polyp-on-some-acoustic-voice-parameters
#11
Elaheh Akbari, Sadegh Seifpanahi, Ali Ghorbani, Farzad Izadi, Farhad Torabinezhad
Background: Vocal abuse and misuse would result in vocal fold polyp. Certain features define the extent of vocal folds polyp effects on voice acoustic parameters. The present study aimed to define the effects of polyp size on acoustic voice parameters, and compare these parameters in hemorrhagic and non-hemorrhagic polyps. Methods: In the present retrospective study, 28 individuals with hemorrhagic or non-hemorrhagic polyps of the true vocal folds were recruited to investigate acoustic voice parameters of vowel/ æ/ computed by the Praat software...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749983/from-negligence-to-perception-of-complexities-in-adherence-to-treatment-process-in-people-with-diabetes-a-grounded-theory-study
#12
Seyedeh Narjes Mousavizadeh, Tahereh Ashktorab, Fazlollah Ahmadi, Mitra Zandi
Background: Poor adherence of patients with type 2 diabetes to treatment is one of the most complex and important clinical concerns. It is the main issue of the present decade and acknowledged as a challenge to control and treat diabetes. This study was carried out to explore and understand how adherence to treatment process occurs among Iranian patients with type 2 diabetes. Methods: The present study is qualitative with grounded theory approach. The data were collected from December 2015 to July 2016 in Tehran (Iran) through individual semi-structured in-depth interviews, field notes, and memos from 21 patients with type 2 diabetes; combined with two members of their families and a healthcare professional...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749982/prevalence-of-multiple-coronary-artery-disease-risk-factors-in-kerman-a-population-based-study-in-southeast-iran
#13
Hamid Najafipour, Mahdi Afshari, Farzaneh Rostamzadeh
Background: The risk of disease with 1 risk factor is increased by the presence of additional risk factors. The goal of this study was to assess the prevalence of multiple coronary artery disease (CAD) risk factors among adults in Kerman, Iran, to identify the population groups most at risk. Methods: The present study included 5900 adults aged between 15 and 75 years in 2011 in Kerman, Iran. They were selected by 1-stage cluster sampling. Blood pressure, fasting blood glucose, lipids, and 6 CAD risk factors were assessed in the study population...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749981/high-prevalence-of-vitamin-d-deficiency-among-iranian-population-a-systematic-review-and-meta-analysis
#14
REVIEW
Reza Tabrizi, Mahmood Moosazadeh, Maryam Akbari, Mohammad Hossein Dabbaghmanesh, Minoo Mohamadkhani, Zatollah Asemi, Seyed Taghi Heydari, Mojtaba Akbari, Kamran B Lankarani
Background: The prevention and correction of vitamin D deficiency requires a precise depiction of the current situation and identification of risk factors in each region. The present study attempted to determine these entities using a systematic review and meta-analysis in Iran. Methods: Articles published online in Persian and English between 2000 and November 1, 2016, were reviewed. This was carried out using national databases such as SID, IranMedex, Magiran, and IranDoc and international databases such as PubMed, Google Scholar, and Scopus...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29749980/delayed-complications-and-long-term-management-of-sulfur-mustard-poisoning-recent-advances-by-iranian-researchers-part-i-of-ii
#15
REVIEW
Emadodin Darchini-Maragheh, Mahdi Balali-Mood
Chemical warfare agents are the most brutal weapons among the weapons of mass destruction. Sulfur mustard (SM) is a potent toxic alkylating agent known as "the King of the Battle Gases". SM has been the most widely used chemical weapon during the wars. It was widely used in World War I. Thereafter, it was extensively employed by the Iraqi troops against the Iranian military personnel and even civilians in the border cities of Iran and Iraq in the period between 1983 and 1988. Long-term incapacitating properties, significant environmental persistence, lack of an effective antidote, and relative ease of manufacturing have kept SM a potential agent for both terrorist and military uses...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398760/primordial-odontogenic-tumor-of-mandible-a-case-with-proposed-diagnostic-criteria
#16
Nilesh Pardhe, Manas Bajpai
No abstract text is available yet for this article.
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398759/tubercular-mycobacterial-spindle-cell-pseudotumour-a-case-report
#17
Deba Prasad Dhibar, Kamal Kant Sahu, Surjit Singh, Amanjit Bal, Abhijit Chougale, Varun Dhir
Pseudotumour is a benign inflammatory lesion. Mycobacterial spindle cell pseudotumour (MSP) is a rare pseudotumour. It is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. MSP is usually associated with mycobacterium avium complex (MAC). Here, we present the case of a 38-year-old gentleman with acquired immune deficiency syndrome (AIDS) who presented with low-grade fever for 1-month duration. Clinically, he had generalised lymphadenopathy...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398758/papillary-carcinoma-of-thyroid-with-nasal-cavity-metastases-a-case-report
#18
Saeid Pourseirafi, Mahmood Shishehgar, Mohammad Javad Ashraf, Mohammad Faramarzi
Papillary thyroid carcinoma (PTC) is one of the most commonly diagnosed types of differentiated carcinoma of the thyroid. It is stated that lung is the most common site of metastasis followed by bone. The incidence of paranasal sinus (PNS) metastasis is fairly uncommon in case of thyroid carcinoma. To the best of our knowledge, no case of metastatic PTC to nasal cavity has been reported. In this case report, we present the first case of papillary carcinoma of the thyroid with nasal cavity metastases in a 55-year-old female...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398757/atypical-kawasaki-disease-presenting-with-hemiparesis-and-aphasia-a-case-report
#19
Ali Nikkhah
Kawasaki disease (KD) is an inflammatory vasculitis. KD is classified into two groups based on clinical characteristics criteria, namely classic and incomplete. Cerebral vascular abnormality, especially arterial ischemic stroke (AIS) is very rare and unusual in KD. Here, we report a 4-year-old boy who was referred to our tertiary pediatric center with abrupt right hemiparesis and aphasia. At admission time, he had febrile illness and was toxic. On physical examination, we found unilateral left submandibular lymphadenopathy...
January 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29398756/pachydermoperiostosis-in-a-patient-with-crohn-s-disease-treatment-and-literature-review
#20
Maryam Mobini, Ozra Akha, Hafez Fakheri, Hadi Majidi, Sanam Fattahi
Pachydermoperiostosis (PDP) is a rare disorder characterized by pachydermia, digital clubbing, periostitis, and an excess of affected males. It is the primary form of hypertrophic osteoarthropathy (HOA) and there are some rare associations of PDP with other disorders. Here we describe a patient with Crohn's disease associated with PDP. A 26-year-old man, who was a known case of Crohn's disease, referred with diffuse swelling in the upper and lower limbs and cutis verticis gyrata since 7 years ago. PDP was suspected and endocrinological and radiological studies were conducted for the evaluation of underlying disease...
January 2018: Iranian Journal of Medical Sciences
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