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Iranian Journal of Medical Sciences

Yousef Veisani, Ali Delpisheh, Kourosh Sayehmiri, Ghobad Moradi, Jafar Hassanzadeh
No abstract text is available yet for this article.
September 2016: Iranian Journal of Medical Sciences
Jafar Nasiri, Soleiman Kheiri, Abolfazl Khoshdel, Amirgholi Jafari Boroujeni
No abstract text is available yet for this article.
September 2016: Iranian Journal of Medical Sciences
Mohammad Miryounesi, Soudeh Ghafouri-Fard, Majid Fardaei
Congenital recessive myotonia is a rare genetic disorder caused by mutations in CLCN1, which codes for the main skeletal muscle chloride channel ClC-1. More than 120 mutations have been found in this gene. The main feature of this disorder is muscle membrane hyperexcitability. Here, we report a 59-year male patient suffering from congenital myotonia. He had transient generalized myotonia, which started in early childhood. We analyzed CLCN1 sequence in this patient and other members of his family. We found a new missense mutation in CLCN1 gene (c...
September 2016: Iranian Journal of Medical Sciences
Aysen Boza, Barıs Boza, Murat Api
Cesarean scar pregnancy (CSP) is a rare, but life-threatening type of ectopic pregnancy. An exact and early diagnosis of CSP is very important for prognosis. The aim of the present study was to describe 4 women with CSP and discuss their clinical presentations, diagnoses, and various management options along with the published literature. Four women with a suspicion of CSP or cervical pregnancy were referred to our hospital between August 2013 and January 2014. All the patients were counseled about medical management options...
September 2016: Iranian Journal of Medical Sciences
Bizhan Ziaeean, Sahar Sohrabi-Nazari
Parathyroid adenoma is a benign tumor of the parathyroid glands. The cause of most parathyroid adenomas is unknown. Parathyroid adenoma increases the secretion of parathyroid hormone and results in primary hyperparathyroidism. High amounts of parathyroid hormone in the blood cause the imbalance of calcium, which leads to various complications such as kidney stones, depression, lethargy, nausea, vomiting, abdominal pain, myalgia, bone and joint pain, hoarseness, etc. Oropharyngeal dysphagia is defined as having problem in swallowing due to abnormalities in the structure and function of oropharynx and other related organs...
September 2016: Iranian Journal of Medical Sciences
Mohammad Reza Razeghinejad, Masoumeh Masoumpour, Mohammad Hossein Eghbal, Jonathan S Myers, Marlene R Moster
Glaucoma management in pregnant patients is a real challenge, especially when the glaucoma is not controlled with medications. We report the results of 6 incisional glaucoma surgeries for the management of medically uncontrolled glaucoma patients during pregnancy. This retrospective, case series was conducted on the 6 eyes of 3pregnant patients with uncontrolled glaucoma using maximum tolerable medications. Details of the glaucoma surgical management of these patients as well as their postoperative care and pregnancy and clinical outcomes on longitudinal follow-up are discussed...
September 2016: Iranian Journal of Medical Sciences
Vinay Kumar, Sandeep Kumar Sharma, K Nagarajan, Praveen Kumar Dixit
Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These groups were treated with pentylenetetrazol (45 mg/kg on days 8, 10, and 12 and 70 mg/kg on day 14 day, i.p.); sodium valproate (200 mg/kg, p...
September 2016: Iranian Journal of Medical Sciences
Zahra Naseri, Mohammad Yousef Alikhani, Seyed Hamid Hashemi, Farideh Kamarehei, Mohammad Reza Arabestani
Brucellosis is a widespread zoonotic disease causing considerable economic and public health problems. Despite animal vaccination, brucellosis remains endemic in some areas such as Iran, especially in the western Iranian province of Hamadan. We sought to detect some of the most common virulence-associated genes in Brucella isolated from human blood cultures to determine the prevalence of some virulence genes among Brucella isolates. Fifty-seven isolates were studied from patients with a clinical diagnosis of brucellosis who referred to the Infectious Diseases Ward of Sina Hospital in Hamadan Province, Iran, between April 2013 and July 2014...
September 2016: Iranian Journal of Medical Sciences
Susan Abadi, Ghamartaj Khanbabaee, Kourosh Sheibani
Speech delay with an unknown cause is a problem among children. This diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. The present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. In this cross-sectional study, we compared click auditory brainstem responses between 261 children who were clinically diagnosed with delayed speech with unknown causes based on normal routine auditory test findings and neurological examinations and had >12 months of speech delay (case group) and 261 age- and sex-matched normally developing children (control group)...
September 2016: Iranian Journal of Medical Sciences
Cambyz Irajie, Milad Mohkam, Navid Nezafat, Saeed Hosseinzadeh, Mahmood Aminlari, Younes Ghasemi
BACKGROUND: Glutaminase (EC catalyzes the hydrolytic degradation of L-glutamine to L-glutamic acid and has been introduced for cancer therapy in recent years. The present study was an in silico analysis of glutaminase to further elucidate its structure and physicochemical properties. METHODS: Forty glutaminase protein sequences from different species of Escherichia and Bacillus obtained from the UniProt Protein Database were characterized for homology search, physiochemical properties, phylogenetic tree construction, motif, superfamily search, and multiple sequence alignment...
September 2016: Iranian Journal of Medical Sciences
Behzad Dehghani, Mohammad Mottamedifar, Hossein Khoshkharam-Roodmajani, Amir Hassanzadeh, Kamyar Zomorrodian, Amir Rahimi
BACKGROUND: Outer membrane proteins (OMPs) constitute the main structure and about half of the cell wall of Gram-negative bacteria. The OMPs of Escherichia coli (E. coli) play an important role in its drug resistance. Previous studies have shown that the OMPs of E. coli enhance its pathogenic effects by helping the bacterium to evade the immune defense and promote its adsorption to host cells. We sought to compare E. coli isolates collected from different hospital wards and to perform a primary investigation of the association between the serotypes and profiles of their OMPs...
September 2016: Iranian Journal of Medical Sciences
Sarika Johari, Chaitanya Joshi, Tejal Gandhi
BACKGROUND: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to unravel the molecular mechanism through cytokine regulation in rats in experimental IBD. METHODS: Sprague Dawley rats were randomly allocated to 5 groups (n=6)...
September 2016: Iranian Journal of Medical Sciences
Wei-Min Zhang, Zhi-Ren Zhang, Yong-Gang Zhang, Yan-Sheng Gao
BACKGROUND: Pigment epithelium-derived factor (PEDF) is regarded as a multifunctional protein possessing neurotrophic and neuroprotective properties. PEDF has a very short half-life, and it would require multiple injections to maintain a therapeutically relevant level without a delivery system. However, multiple injections are prone to cause local damage or infection. To overcome this, we chose a cell-based system that provided sustained delivery of PEDF and compared the effect of weekly injections of PEDF and neural stem cell (NSC)-based intraocular administration of PEDF on retinal ganglion cell (RGC) survival and axon regeneration after optic nerve injury...
September 2016: Iranian Journal of Medical Sciences
Sadegh Seifpanahi, Farzad Izadi, Ali-Ashraf Jamshidi, Farhad Torabinezhad, Javad Sarrafzadeh, Siavash Mohammadi
BACKGROUND: Repeated efforts by researchers to impose voice changes by laryngeal surface electrical stimulation (SES) have come to no avail. This present pre-experimental study employed a novel method for SES application so as to evoke the motor potential of the internal superior laryngeal nerve (ISLN) and create voice changes. METHODS: Thirty-two normal individuals (22 females and 10 males) participated in this study. The subjects were selected from the students of Iran University of Medical Sciences in 2014...
September 2016: Iranian Journal of Medical Sciences
Fatemeh Haidari, Mehrnoosh Zakerkish, Majid Karandish, Azadeh Saki, Sakineh Pooraziz
BACKGROUND: Low serum 25-hydroxy vitamin D (25(OH)D) has been shown to correlate with an increased risk of type 2 diabetes mellitus (T2DM). The objective of this study was to investigate the association between serum 25(OH)D and glycemic and inflammatory markers in non-obese patients with T2DM. METHODS: Eighty-four non-obese patients with T2DM were recruited in this cross-sectional study. Demographic, anthropometric, and dietary information was obtained from all the participants...
September 2016: Iranian Journal of Medical Sciences
Sampan S Bist, Vivek Ahuja, Vinish Agrawal, Sagar Modi
No abstract text is available yet for this article.
July 2016: Iranian Journal of Medical Sciences
Fatma Yıldırım, İskender Kara, Burcu Bilaloğlu, Gonca Erbaş, Melda Türkoglu, Gülbin Aygencel
No abstract text is available yet for this article.
July 2016: Iranian Journal of Medical Sciences
Avradip Santra, Saumen Nandi, Saibal Mondal, Subhankar Chakraborty
Superior vena cava (SVC) syndrome is not an uncommon occurrence in patients with malignancy and it is often described as a medical emergency. In majority of the cases, SVC syndrome occurs due to mechanical obstruction of the SVC by extraluminal compression with primary intrathoracic malignancies. However, intraluminal obstruction due to thrombosis can also produce symptoms and signs of SVC syndrome. Clot-related SVC obstruction is mostly associated with indwelling central venous catheter and pacemaker leads, although such thrombosis can occur spontaneously in a background of a hypercoagulable state, e...
July 2016: Iranian Journal of Medical Sciences
Aytaç Gülcü, Naciye Sinem Gezer, Şevket Baran Uğurlu, Ahmet Yiğit Göktay
Mycotic aortic aneurysms account for 1-3% of all aortic aneurysms. The management of this disease is controversial. Since open surgical repair is associated with high morbidity and mortality rates, endovascular aneurysm repair is an alternative treatment method with promising early and midterm outcomes, although its long-term durability is unknown. Secondary aortoenteric fistulas may occur iatrogenically after either aortic reconstructive surgery or endovascular repair. As the number of aneurysms managed with endovascular aneurysm repair has substantially increased, cases of aortoenteric fistulas referred for endovascular repair are augmented...
July 2016: Iranian Journal of Medical Sciences
Freidoun Sabzi, Reza Faraji
The left atrium is the most common location of myxomas, which are benign tumors. Only a few cases of myxomas in pregnancies have been reported. Our thorough medical literature search showed only 17 reported cases in the course of pregnancy. Myxomas during pregnancy and in the preterm period constitute a serious phenomenon that can mimic an early sign of a life-threatening pathology like severe mitral stenosis. We describe a 33-year-old woman, who presented with acute dyspnea to a gynecology center and was referred to our hospital for further evaluation of pulmonary embolism...
July 2016: Iranian Journal of Medical Sciences
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