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Iranian Journal of Medical Sciences

Pankaj Nepal, Saeed Intakhab Alam, Narendra Adhikari, Neeta Ghimire, Vijayanadh Ojili, Arash Yousefi
No abstract text is available yet for this article.
September 2018: Iranian Journal of Medical Sciences
Samaneh Bourbour, Masoud Keikha, Jamshid Faghri
Nocardiae are Gram-positive, filamentous, aerobic, relatively slow-growing, and weakly acid-fast bacteria which cause nocardiosis in humans. We describe a 53-year-old patient with chronic bronchitis referred to Al-Zahra Hospital, Isfahan. A bronchial washing sample was taken from the patient. A Nocardia -like microorganism was detected in microscopic evaluation. Based on the phenotypic and 16S rRNA gene sequencing, the isolate was identified as Nocardia thailandica . The patient was treated with trimethoprim-sulfamethoxazole and linezolid...
September 2018: Iranian Journal of Medical Sciences
Hamidreza Davari, Mohammad Bagher Rahim, Reza Ershadi, Shahab Rafieian, Parviz Mardani, Mohammad Rahim Vakili, Ahmad Shirinzadeh
Pectus excavatum is the most common congenital deformity of the chest wall. The most frequently used techniques include Ravitch (costochondral resection) and Nuss (minimally invasive pectus repair of pectus excavatum [MIRPE]). The Nuss technique includes using temporary metallic bars without costochondral resection to correct the chest wall deformity. Modified MIRPE can be learned easily and performed safely with few complications. There are no reports of successful MIRPE in Iran, although the Ravitch technique is well known...
September 2018: Iranian Journal of Medical Sciences
Gholam Hossain Shahcheraghi, Mahzad Javid
The mirror foot is a rare congenital foot anomaly which is often associated with 6- to 8-toed polydactyly. Postaxial polydactyly is the most common form of this anomaly, while central polydactyly is seen infrequently. We report on 2 cases of the central mirror-foot anomaly. Calcaneus duplication and fibular hypoplasia were present in 1 case. We treated both patients by resecting the middle foot rays and narrowing the foot width through cuneiform excision and use of cerclage wires or heavy suture approximation of the remaining adjacent rays...
September 2018: Iranian Journal of Medical Sciences
Naser Shahabi Nejad, Nasim Eftekhari, Shayan Shahabi Nejad
Cutaneous involvement is an unusual complication in brucellosis that has been reported to range between 0.4% and 17%. We here introduce a 40-year-old shepherd, who presented with two ulcerative abscesses in his lower left leg. Cultivation of the abscess aspirate was positive for Brucella abortus . The first titer of his serological test was 1/160, which subsequently rose to 1/640. In countries like Iran where brucellosis is still endemic, it is important to take Brucella species into account among other pyogenic bacteria as a causative agent of cutaneous abscesses...
September 2018: Iranian Journal of Medical Sciences
Sara Keshtgar, Shekufeh Bagheri, Bahareh Ebrahimi
Cooling method was proposed to maintain the sperm quality for several days. Nevertheless, during this procedure, sperm is encountered to "cold shock", and its quality decreases time-dependently. This study was designed to improve the in vitro sperm preservation methods. Thirty normal semen samples were examined in Shiraz, Iran, 2017. Fifteen samples were incubated at 22-27 °C and 15 samples were cooled moderately to 4 °C. Each sample was divided into five subgroups; control, solvent, 200 μM Trolox, 40 μM Coenzyme Q10, and 10 mM ATP...
September 2018: Iranian Journal of Medical Sciences
Mehdi Nikbakht Dastjerdi, Asaad Azarnezhad, Batool Hashemibeni, Mansour Salehi, Mohammad Kazemi, Zahra Babazadeh
Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present study aimed to evaluate the effect of 5-Aza-CdR on the proliferation of human pancreatic cancer cell line (PANC-1) and the expression of RASSF1A and Bax genes. Methods: PANC-1 cells were cultured and treated with 5 and 10 µM/L of 5-Aza-CdR for 24, 48, 72, and 96 hours and the percentages of cell viability and apoptosis were measured by MTT and flow cytometry...
September 2018: Iranian Journal of Medical Sciences
Saeedeh Saeb, Hassan Azari, Zohreh Mostafavi-Pour, Amir Ghanbari, Sepideh Ebrahimi, Pooneh Mokarram
Background: Differentiating oligodendrocyte precursor cells (OPCs) into oligodendrocytes could be improved by inhibiting signaling pathways such as Wnt and Notch. 9-cis-retinoic acid (9-cis-RA) and 1,25-dihydroxyvitamin D3 (1,25[OH]2 D3 ) can ameliorate oligodendrogenesis. We investigated whether they could increase oligodendrogenesis by inhibiting the Wnt and Notch signaling pathways. Methods: Cortical neural stem cells were isolated from 14-day-old rat embryos and cultured using the neurosphere assay...
September 2018: Iranian Journal of Medical Sciences
Asieh Karimani, Yasaman Mamashkhani, Amir Moghadam Jafari, Masoumeh Akbarabadi, Mohammad Heidarpour
Background: Diazinon (DZN) is an organophosphate pesticide commonly used for pest control in agriculture. It may engender a variety of negative effects in non-target species, including humans and animals. The objective of the present study was to evaluate the ameliorative properties of captopril (CAP), as a thiol containing an angiotensin-converting enzyme inhibitor, against DZN-induced oxidative stress. Methods: Twenty-eight male Wistar rats were divided randomly into 4 groups...
September 2018: Iranian Journal of Medical Sciences
Ehsan Afzal, Sedigheh Alinezhad, Marjan Khorsand, Mohammad Javad Khoshnood, Mohammad Ali Takhshid
Background: The synergistic effects of valproic acid (VPA), lithium (Li), and celecoxib (CX) have been shown in combination therapy against the proliferation and metastasis of numerous cancers. Angiogenesis plays a critical role in the pathogenesis of tumor growth and metastasis. The aim of the present study was to evaluate the antiangiogenic effects of VPA, lithium chloride (LiCl), and CX, alone or in 2-by-2 combinations, using the chicken chorioallantoic membrane (CAM) assay. Methods: Fertilized chicken eggs were randomly divided into 10 groups: control, VPA (1...
September 2018: Iranian Journal of Medical Sciences
Reza Safdari, Marjan Ghazi Saeedi, Hossein Masoumi-Asl, Peyman Rezaei-Hachesu, Kayvan Mirnia, Niloofar Mohammadzadeh, Taha Samad-Soltani
Background: Success of infection treatment depends on the availability of accurate, reliable, and comprehensive data, information, and knowledge at the point of therapeutic decision-making. The identification of a national minimum data set will support the development and implementation of an effective surveillance system. The goal of this study was to develop a national antimicrobial resistance surveillance minimum data set. Methods: In this cross-sectional and descriptive study, data were collected from selected pioneering countries and organizations which have national or international antimicrobial resistance surveillance systems...
September 2018: Iranian Journal of Medical Sciences
Fatemeh Amini, Hasan Ali Krimpour, Mahdi Ghaderi, Siavash Vaziri, Shirin Ferdowsi, Mohsen Azizi, Sabrieh Amini
Background: This study aimed to investigate the occurrence of aminoglycoside resistance and the prevalence of the resistance-modifying enzyme genes, ant(3")-III, ant(6')-Ia, aac(6')-Ie-aph(2")-Ia , and aph(2')-Id , in Enterococcus strains isolated in Kermanshah Province, west of Iran. Methods: In this cross-sectional study, 108 enterococcal isolates from urine, wound, blood, and cerebrospinal fluid samples were collected. The Enterococcus species were recognized by standard phenotypic/biochemical tests...
September 2018: Iranian Journal of Medical Sciences
Dorsa Daneshbakhsh, Jinous Asgarpanah, Parvaneh Najafizadeh, Tayebeh Rastegar, Zahra Mousavi
Background: Mentha mozaffarianii , an endemic species from the Labiatae family, is used in Iranian traditional medicine. This study evaluated the acute and repeated oral toxicity of the Mentha mozaffarianii essential oil (MMEO) in rats and mice. Methods: To assess the toxicity profile of the MMEO, we administered the essential oil to 48 rats and mice of both sexes by gavage in acute and repeated models. In acute toxicity, the animals were administered the MMEO (2000 mg/kg) and were monitored for 14 days...
September 2018: Iranian Journal of Medical Sciences
Mohammad Rafati, Seyed Vahid Hosseini, Farid Moradian, Mozhdeh Zamani, Hajar Khazraei, Maral Mokhtari
Background: Perianal fistula is a complicated disorder and most difficult to manage. New treatment methods would help surgeons to achieve a better outcome in patients with perianal fistula. Human amniotic membrane (HAM) has positive effects on wound healing in several conditions. The present study aimed to further determine the effect of HAM on wound healing of perianal fistula in rabbits. Methods: In a prospective experimental study, 14 male rabbits (aged 4-6 months and weighing 3-4 kg) were randomly divided into 2 groups...
September 2018: Iranian Journal of Medical Sciences
Mahmood Zamirian, Ehsan Samiee, Alireza Moaref, Firoozeh Abtahi, Maryam Tahamtan
Background: Considering the association between cardiac abnormalities and non-alcoholic fatty liver disease (NAFLD), the present study aimed to evaluate the relationship between biopsy-proven NAFLD and functional echocardiographic parameters, including left ventricular (LV) global longitudinal strain (GLS) in asymptomatic individuals. Methods: Thirty asymptomatic patients with liver biopsy-proven NAFLD and the same number with no evidence of fatty liver in ultrasonography were enrolled in the study as cases and controls, respectively...
September 2018: Iranian Journal of Medical Sciences
Mehdi Akbartabar Toori, Faezeh Kiani, Fatemeh Sayehmiri, Kourosh Sayehmiri, Yousof Mohsenzadeh, Rahim Ostovar, Parvin Angha, Yazdan Mohsenzadeh
Background: Chronic and abnormal increase of different types of dyslipidemia leads to some important diseases, such as constriction and abstraction of vessels in various parts of the body, especially in the heart. High lipid profile, such as increased total cholesterol and LDL as well as decreased HDL are recognized as cardiovascular disease risk factors. The present study aimed to estimate the prevalence of different types of dyslipidemia in Iran by a meta-analysis method. Methods: A literature search for studies published during 1998-2015 was carried out using both Persian and English databases (SID, Magiran, IranMedex, MedLib, PubMed, and Scopus)...
September 2018: Iranian Journal of Medical Sciences
Priyanka Anand, Namrata Sarin
In India, pulmonary tuberculosis accounts for 85% of cases and extrapulmonary tuberculosis accounts for 15% of cases with bone and joint involvement is seen in 1 to 3% of cases. Primary tuberculous osteomyelitis of the sternum is a rare form of extrapulmonary tuberculosis. A 51-year-old male presented with 10 years history of swelling over the anterior chest wall and pain for past 6 months. Fine-needle aspiration cytology (FNAC) revealed a markedly granular necrotic background. Ziehl-Neelsen staining was positive for acid-fast bacilli and a diagnosis of the tubercular abscess was made...
July 2018: Iranian Journal of Medical Sciences
Mirela Mačkić-Đurović, Meliha Stomornjak-Vukadin, Slavka Ibrulj
We report an extremely rare case of Turner syndrome mosaicism in a 30-year-old woman. At least 100 metaphases were observed and analyzed through GTG banding with over 550 band resolutions observed. G-banded chromosome analysis revealed a mosaic female karyotype involving 3 different cell lines. One cell line (90% of the analyzed metaphases) presented monosomy X, while 6% of the cells showed trisomy of chromosome 21 and 4% of the cells exhibited a normal female karyotype. Fluorescence in situ hybridization with a locus-specific probe for trisomy 21 and CEP X for monosomy X substantiated the results obtained from karyotyping...
July 2018: Iranian Journal of Medical Sciences
C Danny Darlington, G Fatima Shirly Anitha
Ascariasis is a common worm infestation in developing and under-developed countries. It is caused by the ingestion of food contaminated with Ascaris eggs from faeces and is more common in places with poor sanitation. Almost 25% of the world population is infested by Ascaris lumbricoides. Although ascariasis is a chronic disease, it can present as acute abdomen rarely. The wandering nature of Ascaris in and out of the bowel causes various abdominal complications such as intestinal obstruction, perforation, biliary ascariasis, pancreatic ascariasis, liver abscess, appendicitis, and Meckel's diverticulitis...
July 2018: Iranian Journal of Medical Sciences
Setare Nasiri, Shahrzad Sheikh Hasani, Azamosadat Mousavi, Mitra Modarres Gilani, Setare Akhavan, Mohammad Rahim Vakili
Choriocarcinoma and placental site trophoblastic tumor (PSTT) are rare varieties of gestational trophoblastic disease (GTD). PSTT alone constitutes about 1-2% of all trophoblastic tumors, which presents at early reproductive age and the serum beta-hCG level is much lower than choriocarcinoma. This tumor usually invades the myometrium and its depth of penetration is a prognostic factor. The first case report is regarding a 33-year-old woman with vaginal bleeding 3 months after abortion. The ultrasound exhibited heterogeneous and hypervascular mass related to previous cesarean scar...
July 2018: Iranian Journal of Medical Sciences
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