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Current Eye Research

Joaquín Fernández, Manuel Rodríguez-Vallejo, Javier Martínez, Ana Tauste, David P Piñero
Purpose/Aim: To evaluate the impact of ocular parameters on the visual performance achieved with the multifocal intraocular lens (IOL) Bi-Flex M 677MY. MATERIALS AND METHODS: 26 subjects were included in the current study. Several physiological variables were retrieved from the 3-month follow-up visit, including pupil diameter and distance from pupil center to the vertex normal of the anterior cornea (µ). These variables were also obtained in the preoperative visit. Binocular and monocular visual acuity defocus curves were measured at 1 and 3 months after surgery, respectively...
May 18, 2018: Current Eye Research
Ute Kaiser, Karin U Loeffler, Jennifer Nadal, Frank G Holz, Martina C Herwig-Carl
PURPOSE: Basal cell carcinoma (BCC) is a locally invasive skin tumor which can be subdivided into a circumscribed nodular and an invasive fibrosing subtype. There is increasing evidence that macrophages play an important role in interacting between tumor cells and their microenvironment, thereby affecting not only the invasive potential but also the patients' prognosis. Thus, we wanted to compare these two BCC variants with regard to tumor-related inflammation, COX-2 expression, distribution and polarization of tumor-associated macrophages...
May 18, 2018: Current Eye Research
Sunee Chansangpetch, Shan C Lin
Rapid improvements in optical coherence tomography (OCT) technology have allowed for enhancement of both image resolution and scanning speed, and the development of vascular assessment modality. Optical coherence tomography angiography (OCTA) is the non-invasive in vivo imaging of the vasculature located within the retina and optic nerve head area. The principle of OCTA is to use the variations in OCT signals caused by moving particles as the contrast mechanism for imaging of flow. Several algorithms which aim to maximize the contrast signal and minimize the noise have been developed including the phase-based techniques, intensity-based techniques (e...
May 14, 2018: Current Eye Research
Magdalena Cortes, Graziana Esposito, Roberto Sacco, Véronique Bernadette Gillet, Andrea Ianni, Alessandra Micera
PURPOSE: To investigate Nerve Growth Factor (NGF) and Nitric Oxide synthase (iNOS) levels in tears obtained from Video Display Terminal (VDT) workers and correlate their expression with ocular signs and symptoms Methods: A total of 120 VDT workers (62M/58F; 31 to 63 years old) and 40 age/sex matched no-VDT volunteers (19M/21F; 30 to 60 years old) were enrolled in the study. Participants completed the OSDI questionnaire and were subjected to clinical assessment of ocular surface status, including ocular symptoms and tear film parameters...
May 9, 2018: Current Eye Research
Li Nie, Aiwu Fang, Weihua Pan, Han Ye, Yau Kei Chan, Lin Fu, Jia Qu
PURPOSE: To evaluate the feasibility, efficacy and safety of Ex-PRESS implantation combined with phacoemulsification surgery in primary angle-closure glaucoma (PACG) with cataract. MATERIALS AND METHODS: This is a prospective, nonrandomized study. A total of 34 eyes of 34 subjects were enrolled. The assessments were conducted preoperatively and postoperatively at 1 week and 1, 3, 6, 12, 18, 24, 30, 36 months. The assessments included intraocular pressure (IOP), best corrected visual acuity (BCVA), the number of glaucoma medications, corneal endothelial cell density (ECD) and related complications, if any...
May 2, 2018: Current Eye Research
Ho Sik Hwang, Min Young Chun, Jin Sun Kim, Bumjo Oh, Sang Ho Yoo, Bum-Joo Cho
PURPOSE: To investigate risk factors for high myopia in the general Korean population. METHODS: In this nationwide population study, the dataset of the Korea National Health and Nutrition Examination Survey 2008-2012 was analyzed. The study cohort included 11,703 participants, aged 25-49 years, who underwent neither refractive nor cataract surgery. The association between demographic, socioeconomic, behavioral, and systemic variables and high myopia were investigated...
May 2, 2018: Current Eye Research
Cem Cankaya, Tongabay Cumurcu, Abuzer Gunduz, Ilknur Fırat
PURPOSE: To evaluate alterations in the corneal endothelial layer in Behçet's disease (BD) with inactive ocular involvement using specular microscopy. MATERIALS AND METHODS: Thirty-three eyes of 33 BD patients who had at least one anterior segment involvement and no active inflammation in the last 3 months were included in the study (group 1). Twenty-seven of the thirty-three BD patients had an anterior uveitis attack and six of them had a panuveitis (both anterior and posterior involvement) attack...
May 1, 2018: Current Eye Research
Tuba Celik
PURPOSE: To compare the outcomes of autograft fixation using patient's own blood coagulum and using sutures after pterygium excision. METHODS: In this prospective clinical study 30 eyes of 30 patients with primary pterygium were randomly assigned into two groups: Group 1 (15 eyes) underwent autograft fixation with 10/0 nylon sutures and Group 2 (15 eyes) underwent autograft fixation by using in situ blood coagulum following pterygium excision. Primary outcome measure of this study was graft failure and displacement...
April 30, 2018: Current Eye Research
Yichi Zhang, Guangming Jin, Charlotte Aimee Young, Qianzhong Cao, Junxiong Lin, Jianqiang Lin, Yiyao Wang, Danying Zheng
Purpose This study aims to describe the characteristics of corneal astigmatism before surgery in congenital ectopia lentis (CEL) patients. Methods This retrospective study reviewed 306 CEL patients from 1st January 2006, to 31st December 2015. One eye was randomly selected from each patient when the patient had bilateral EL. The influence of sex, laterality, and Marfan syndrome on corneal astigmatism in different age subgroups was evaluated and compared. The correlation between age and corneal astigmatism was evaluated...
April 26, 2018: Current Eye Research
Tammy Z Movsas, Robert Sigler, Arivalagan Muthusamy
Purpose/Aim: Luteinizing hormone (LH) is known to function as a key regulator of VEGF expression in reproductive organs. In recent years, LH has also been detected in human vitreous and LH receptors have been identified in human retina. This study was aimed to investigate a potential correlation between LH and VEGF levels in healthy mammalian eyes to provide supporting evidence of LH's potential involvement in intraocular VEGF regulation. METHODS: 18 bovine and 30 porcine eyes were procured from an abattoire and VEGF and LH levels were measured in the vitreous extracted from these eyes by commercially-available bovine & porcine ELISA assay kits...
April 20, 2018: Current Eye Research
Natasha Najwa Nor Arfuzir, Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Sabrilhakim Sidek, Alexander Spasov, Alexander Ozerov, Nafeeza Mohd Ismail
PURPOSE: Retinal ganglion cell apoptosis in glaucoma is associated with elevated levels of endothelin-1 (ET1), a potent vasoconstrictor. ET1-induced retinal ischemia leads to altered expression of nitric oxide synthase (NOS) isoforms leading to increased formation of nitric oxide (NO) and retinal nitrosative stress. Since magnesium (Mg) is known to improve endothelial functions and reduce oxidative stress and taurine (TAU) possesses potent antioxidant properties, we investigated the protective effects of magnesium acetyltaurate (MgAT) against ET1-induced nitrosative stress and retinal damage in rats...
April 20, 2018: Current Eye Research
Adriano Baccega, Denny Marcos Garcia, Antonio Augusto Velasco Cruz
PURPOSE: To measure the long-term effects of frontalis slings with fascial tissues on the downward eyelid saccadic movements Methods: Downward lid saccades for 10, 20, 30 40 and 50 degrees of downgaze were measured in a sample of 19 patients with congenital ptosis who underwent frontalis slings with fascia lata (autogeneous and banked) and temporalis fascia. Mean postoperative time was 10.7 years ± 3.8 SD. Seventeen age-matched normal subjects comprised the control group. Lid movements as well as the magnitude of brow motion were quantified in all participants with an opto-eletronic device that automatically corrected any head movement...
April 20, 2018: Current Eye Research
Junki Kwon, Kyung Rim Sung, Jaehyuck Jo, Sung Ho Yang
PURPOSE: To investigate glaucoma progression and its relationship with corrected and uncorrected intraocular pressure (IOP) in patients with a history of refractive corneal surgery (RCS). METHODS: Totally, 56 eyes of 56 primary open-angle glaucoma patients who had a history of RCS were included. Mean keratometry and central corneal thickness were measured at the time of glaucoma diagnosis. Three IOP measurements, i.e., uncorrected IOP (UC IOP) and corrected IOP calculated by applying the Kohlhaas (CK IOP) and Ehlers (CE IOP) formulas, were used...
April 20, 2018: Current Eye Research
Robert Kromer, Clara Vogt, Lars Wagenfeld, Martin Stephan Spitzer, Birthe Stemplewitz
Introduction Idiopathic epiretinal membrane (ERM) is a proliferation of cells formed on the internal surface of the retina and may cause a slow decrease in visual acuity (VA). The aim of this study was to evaluate the individual layers of the retina by optical coherence tomography (OCT) before and after vitrectomy with ERM peeling in order to refine surgical decision-making. Methods Forty-seven eyes of 45 patients (aged 55-87 years) with ERM were enrolled retrospectively from a tertiary referral centre. OCT examination was performed preoperatively and at a mean of 3...
April 19, 2018: Current Eye Research
Magdalena C Wojciechowski, Daisy Y Shu, Frank J Lovicu
PURPOSE: This study aims to highlight some of the genes that are differentially regulated by ERK1/2-signaling in TGFβ-induced EMT in lens, and their potential contribution to this pathological process. MATERIALS AND METHODS: Rat lens epithelial explants were cultured with or without TGFβ over a 3-day-culture period to induce EMT, in the presence or absence of UO126 (ERK1/2-signaling inhibitor), both prior to TGFβ-treatment, or 24 or 48 hours after TGFβ-treatment...
April 13, 2018: Current Eye Research
Gupta Noopur, Vashist Praveen, Tandon Radhika, Gupta Sanjeev K, Kalaivani Mani, Kumar Deepak
PURPOSE: To assess awareness, barriers, and misconceptions related to eye donation in people with corneal disease as compared to controls in a population setting. MATERIALS AND METHODS: A population-based study was conducted in 25 randomly selected clusters of Rural Gurgaon, Haryana, India, as part of the CORE (Cornea Opacity Rural Epidemiological) study. In addition to ophthalmic examination, knowledge and perceptions regarding eye donation were assessed through a validated questionnaire...
April 13, 2018: Current Eye Research
Ingrida Smeringaiova, Stanislava Reinstein Merjava, Zbynek Stranak, Pavel Studeny, Jan Bednar, Katerina Jirsova
PURPOSE: To assess whether injured porcine endothelium of small and large corneoscleral disc differ in its reparative/regenerative capacity under various conditions of organ culture storage. MATERIAL AND METHODS: 166 paired porcine corneas were trephined to obtain tissues with diameter 12.0 mm and 17.5 mm (with area neighboring endothelial periphery). In tested discs, central endothelium was mechanically wounded. Density of live endothelial cells (LECD), percentage of dead cells (%DC), coefficient of variation and cell hexagonality were assessed in central and paracentral endothelium following 5- or 9-day incubation in medium with 2% or 10% fetal bovine serum...
April 12, 2018: Current Eye Research
Anna Dastiridou, Kenneth Marion, Moritz Niemeyer, Brian Francis, Srinivas Sadda, Vikas Chopra
PURPOSE: To investigate the effects of ambient light level variation on spectral-domain anterior segment optical coherence tomography (SD-ΟCT)-derived anterior chamber angle metrics in Caucasians vs Asians. MATERIALS AND METHODS: Caucasian (n = 24) and Asian participants of Chinese ancestry (n = 24) with open angles on gonioscopy had one eye imaged twice at five strictly controlled, ambient light levels. Ethnicity was self-reported. Light levels were strictly controlled using a light meter at 1...
April 11, 2018: Current Eye Research
Ashutosh Jnawali, Krista M Beach, Lisa A Ostrin
PURPOSE: Guinea pigs are increasingly being used as a model of myopia, and may also represent a novel model of glaucoma. Here, optical coherence tomography (OCT) imaging was performed in guinea pigs. In vivo measurements of retinal, choroidal and optic nerve head parameters were compared with histology, and repeatability and interocular variations were assessed. METHODS: OCT imaging and histology were performed on adult guinea pigs (n = 9). Using a custom program in Matlab, total retina, ganglion cell/nerve fiber layer (GC/NFL), outer retina and choroid thicknesses were determined...
April 11, 2018: Current Eye Research
Koji Namiguchi, Shiro Mizoue, Kiyohiko Ohta, Atsushi Shiraishi
OBJECTIVE: To determine the effect of botulinum toxin A (BTX-A) on the eyelid pressure in patients with benign essential blepharospasm (BEB). METHODS: Twenty normal volunteers (10 men, 10 women; average age 59.7 ± 11.3 years), and 33 patients (12 men, 21 women; average age 61.1 ± 14.7 years) with BEB were studied. The upper and lower eyelid pressures were measured with a blepharo-tensiometer in the normal subjects (N group). The eyelid pressures and intraocular pressures (IOP) were measured before and after the BTX-A injections in the BEB patients (B group)...
April 11, 2018: Current Eye Research
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