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Current Eye Research

Young Hyun Kim, Bo Tan, Meng C Lin, Clayton J Radke
PURPOSE: To evaluate the safety of scleral-lens designs, we model and clinically assess central corneal edema induced by scleral-lens wear for healthy subjects. MATERIALS AND METHODS: Central corneal swelling during scleral-lens wear is measured using optical coherence tomography (OCT). Transport resistances are modeled for oxygen diffusion through the scleral lens and post-lens tear-film (PoLTF), and into the cornea. Oxygen deficiency in the cornea activates anaerobic metabolic reactions that induce corneal edema...
July 17, 2018: Current Eye Research
Zhizhang Dong, Ali Luo, Yifeng Gan, Juan Li
OBJECTIVE: To investigate the expression of amyloid precursor protein (APP) and amyloid beta (Aβ) in cornea and further explore the pathological and ultrastructural changes in corneal epithelium in APPswePS1 transgenic mice. METHODS: 12 wild type mice were grouped into control group and 12 TgAPPswePS1 mice at 8 months old were grouped into the young experiment group (Tg 8M group), and another 12 transgenic mice at least 15 months old were selected into the aged experiment group (Tg-15M group)...
July 17, 2018: Current Eye Research
Hyung Bin Hwang, Su-Young Kim
PURPOSE: To evaluate the influence of prostaglandin (PG) analogues on the ciliary zonular fibers of the crystalline lens using scanning electron microscopy (SEM) of rabbit eyes, and to measure the matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) levels of the aqueous humor and crystalline lens treated with topical PG analogues Methods: Fifty eyes from 25 New Zealand white rabbits were divided into five groups of five rabbits each. In the control group, balanced salt solution was administered via the topical route once a day to the eyes...
July 17, 2018: Current Eye Research
Xiaoqin Yan, Mu Li, Hong Zhang
AIM: To observe post-exercise changes in the lens and Schlemm's canal (SC) in healthy individuals using swept-source optical coherence tomography (SS-OCT). METHODS: Thirty-five healthy, young individuals were recruited and performed aerobic exercise by jogging for 20 minutes. The SC area, SC perimeter, trabecular meshwork (TM) length, TM thickness, lens vault (LV) and lens thickness (LT) were assessed by SS-OCT before and after exercise. RESULTS: Following aerobic exercise, SC area (4260...
July 17, 2018: Current Eye Research
Apurva Yadav, Rajesh Choudhary, Surendra H Bodakhe
PURPOSE: Previously we established a strong association of systemic hypertension with cataract formation. In the present study, we investigated the role of nitric oxide (NO) in the development of cataract formation in CdCl2-induced hypertensive animals. MATERIALS AND METHODS: Hypertension was induced in male albino rats by intraperitoneal administration of CdCl2 (0.5 mg/kg/day) for eight weeks. The NO modulators, 10 µM S-nitrosoglutathione (NO donor) and 1% w/v Nω-nitro-L-arginine methyl ester (L-NAME, NOS inhibitor) were applied topically once a day on the eye cornea during the experimental period...
July 17, 2018: Current Eye Research
Anne Kurtenbach, Gesa Hahn, Christoph Kernstock, Stephanie Hipp, Ditta Zobor, Katarina Stingl, Susanne Kohl, Crystel Bonnet, Saddek Mohand-Saïd, Ieva Sliesoraityte, José-Alain Sahel, Isabelle Audo, Ana Fakin, Marko Hawlina, Francesco Testa, Francesca Simonelli, Christine Petit, Eberhart Zrenner
Purpose The aim of this study is to report on the results of color vision testing in a European cohort of patients with Usher syndrome (USH). We describe the results in relation to Usher type (USH1, USH2), age and visual acuity. Methods and Methods The color vision of 220 genetically confirmed adult USH patients, aged 18-70 years, was analyzed with one of 3 methods: the Farnsworth D-15 Dichotomous test (D-15) along with the Lanthony desaturated 15 Hue tests (D-15d), the Roth 28-Hue test, or the Ishihara 14-plate test...
July 17, 2018: Current Eye Research
Johannes Menzel-Severing, Peter Walter, Wolfgang J Plum, Friedrich E Kruse, Sabine Salla
PURPOSE: To measure corneal endothelial cell (EC) quality and quantity following Descemet membrane (DM) stripping of human donor corneas and continued storage in organ culture medium containing dextran. METHODS: DM stripping was performed in 30 organ cultured, corneoscleral discs. Corneas were divided into 3 groups of 10 corneas each. Baseline mean EC density (cells/mm2 ) was 2372 (SD ± 259) in group 1, 2540 (SD ± 266) in group 2, and 2665 (SD ± 263) in group 3...
July 17, 2018: Current Eye Research
Betul Seher Uysal, Ozge Sarac, Derya Yaman, Emine Akcay, Nurullah Cagil
PURPOSE: To assess changes in optical performance of the cornea in patients with keratoconus following treatment with corneal collagen cross-linking (CXL). MATERIALS AND METHODS: 111 eyes of 111 consecutive keratoconus patients with 12 month follow-up after CXL were included. The changes in the visual acuity, manifest refractive errors and corneal topographic parameters were evaluated. Sirius dual-scanning corneal tomography was used to determine the effectiveness of CXL on each patient's total corneal optical quality; preoperative and 12-month postoperative measurements were analyzed over a 4 mm stimulated pupil and were compared with regards to higher-order corneal aberrations (total amount of higher-order aberrations (HOAs), vertical coma, horizontal coma, vertical trefoil, oblique trefoil, and spherical aberration), vertical and horizontal modulation transfer function (MTF), and Strehl ratio of point spread function (PSF)...
July 17, 2018: Current Eye Research
Christina Mastromonaco, Matthew Balazsi, Pablo Zoroquiain, Evangelina Esposito, Jacqueline Coblentz, Patrick Logan, Miguel N Burnier
Purpose/aim: Posterior capsular opacification (PCO) is the leading complication following cataract surgery. However, PCO grading methods vary between studies and rely on subjective scoring methods, hence they are prone to error. Therefore, software that reduces subjectivity and enhances reproducibility is needed. The aim of the study was to evaluate the reproducibility and objectivity of a novel automated custom-designed PCO detection software. MATERIALS AND METHODS: In total, 165 fixed eyes with intraocular lenses were sectioned to obtain a Miyake Apple view (MAV) image...
July 14, 2018: Current Eye Research
Hee-Young Choi, HyeShin Jeon, Jae Wook Yang, Jeong Hyo Ahn, Jae Ho Jung
PURPOSE: To isolate and culture human extraocular muscle (EOM) myoblasts and facilitate their differentiation to myotubes in vitro, and to determine whether these myoblasts express thyroid stimulating hormone receptor (TSHR). MATERIALS AND METHODS: Human EOM myoblasts were isolated from extraocular muscle samples, and identified by immunostaining for PAX7 and MYOD1 (markers of human skeletal myoblasts), and western blot for desmin (muscle marker). In addition, we investigated the expressions of SHOX2 (a genetic marker of extraocular muscle myoblasts) and HOXC10 (an exclusive marker of hind-limb muscle-derived myoblasts) by RT-PCR...
July 14, 2018: Current Eye Research
Giuseppe Giannaccare, Alessandro Finzi, Stefano Sebastiani, Fedele Greco, Piera Versura, Emilio C Campos
PURPOSE: To compare the efficacy and tolerability of diclofenac and bromfenac ophthalmic solutions as adjunctive therapy after cataract surgery. MATERIALS AND METHODS: This prospective randomized controlled study included 130 patients who underwent cataract surgery. One hundred patients were randomized to receive postoperatively diclofenac 0.1% (four times daily for 28 days, Group 1) or bromfenac 0.09% (twice daily for 14 days, Group 2) ophthalmic solutions in addition to steroid-antibiotic combination...
July 14, 2018: Current Eye Research
Ahmed Abass, Riccardo Vinciguerra, Bernardo T Lopes, FangJun Bao, Paolo Vinciguerra, Renato Ambrósio, Ahmed Elsheikh
PURPOSE: To identify the relative positions of geometrical and visual axes of the eye and present a method to locate the visual centre when the geometrical axis is taken as a reference. METHODS: Topography elevation data was collected using a Pentacam HR ® topographer from 2040 normal eyes of 1020 healthy participants in Brazil, China and Italy. A three-dimensional, rotation algorithm, a first-order Zernike polynomial fit and a nonlinear least-squares error function was used within an optimisation function to locate the geometrical axis and the visual centre of each eye...
July 14, 2018: Current Eye Research
Cameron K Postnikoff, Carrie Huisingh, Gerald McGwin, Kelly K Nichols
PURPOSE: Leukocytes accumulate in the eye with sleep, but little is known about the presence or absence of leukocytes in awake, open eye tears. This study sought to compare normal and dry eye subjects for daily variation in open eye leukocyte composition. MATERIALS AND METHODS: Ten normal subjects and nine dry eye subjects were enrolled. Subjects were trained for self-collection of tear samples using an ocular surface wash with 5 mL of phosphate buffered saline per eye...
July 13, 2018: Current Eye Research
(no author information available yet)
No abstract text is available yet for this article.
July 9, 2018: Current Eye Research
Fabian Anders, Carolina Mann, Aiwei Liu, Julia Teister, Sebastian Funke, Solon Thanos, Franz Grus, Norbert Pfeiffer, Verena Prokosch
PURPOSE: Glaucoma is one of the leading causes of blindness worldwide with age being an important risk factor. However, the pathogenesis remains poorly understood. Aim of this study was to focus on age-dependent molecular changes in an experimental animal model of glaucoma. METHODS: Intraocular pressure was elevated in Sprague Dawley rats aged three, fourteen and forty-seven weeks for a period of seven weeks by episcleral vein cauterization. Ganglion cell loss was monitored by an immunohistochemical staining of the Brain-specific homeobox/POU domain protein 3A positive cells in retinal flat-mounts and spectral-domain optical coherence tomography measuring the retinal nerve fiber layer thickness...
July 6, 2018: Current Eye Research
Ofira Zloto, Eedy Mezer, Luis Ospina, Branislav Stankovic, Tamara Wygnanski-Jaffe
No abstract text is available yet for this article.
July 2, 2018: Current Eye Research
Tammy Z Movsas, Robert Sigler, Arivalagan Muthusamy
Purpose/Aim: VEGF dysregulation is implicated in the pathogenesis of retinopathy of prematurity (ROP). Identifying the factors that contribute to VEGF regulation during normal retinal vascularization is the key to ROP prevention. Currently, physiologic hypoxia is thought to be responsible for retinal VEGF regulation in utero. However, a potential hormonal contribution to VEGF regulation during eye development has not been fully investigated. The placental hormone, human chorionic gonadotropin and the pituitary hormone, luteinizing hormone (LH) induce VEGF expression in several tissue types...
July 2, 2018: Current Eye Research
Xuling Chen, Xuyang Yao, Ying Chi, Chunying Guo, Jing Zhang, Jun Li, Shijie Zhang, Xin Rong, Louis R Pasquale, Liu Yang
PURPOSE: We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and uveitis stratified in various ways. METHODS: This was a cross-sectional,case-control, observational study. One hundred and seven uveitis patients and 130 control subjects were included. We used a JH-1004 capillaroscope to perform nailfold capillary video microscopy on the fourth and fifth digits of each subject's non-dominant hand. Videos were evaluated for hemorrhages, dilated capillary loops > 25um, and avascular zones > 200 um...
July 2, 2018: Current Eye Research
Laura Vanden Daele, Charlotte Boydens, Joke Devoldere, Katrien Remaut, Johan Van de Voorde
Purpose/Aim of the study: the retinal relaxing factor (RRF) is an unidentified paracrine factor, which is continuously released from retinal tissue and causes smooth muscle cell relaxation. This study tried to identify the cellular source of the RRF. Furthermore, the possible RRF release by voltage-dependent sodium channel activation and the calcium-dependency of the RRF release was investigated. MATERIALS AND METHODS: mouse femoral arteries were mounted in myograph baths for in vitro isometric tension measurements...
July 2, 2018: Current Eye Research
Kengo Takahashi, Tsuneaki Omae, Shinji Ono, Takayuki Kamiya, Akira Tanner, Akitoshi Yoshida
PURPOSE: Thrombin, a serine protease, causes organ-specific responses to vessels. However, the mechanism by which thrombin affects the retinal microcirculation remains unclear. We examined the effects of thrombin on the retinal microvasculature and signaling mechanisms. METHODS: Porcine retinal arterioles were isolated, cannulated, and pressurized (55 cmH2 O) without flow in this in vitro study. Videomicroscopy techniques recorded changes in diameter in the retinal arterioles in response to thrombin at concentrations ranging from 0...
July 2, 2018: Current Eye Research
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