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Current Eye Research

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https://www.readbyqxmd.com/read/28506091/reaching-the-unreachable-novel-approaches-to-telemedicine-screening-of-underserved-populations-for-vitreoretinal-disease
#1
Ann P Murchison, Julia A Haller, Eileen Mayro, Lisa Hark, Emily Gower, Carrie Huisingh, Lindsay Rhodes, David S Friedman, David J Lee, Byron L Lam
Telemedicine involves electronic communication between a physician in one location and a patient in another location to provide remote medical care. Ophthalmologists are increasingly employing telemedicine, particularly in retinal disease screening and monitoring. Telemedicine has been utilized to decrease barriers to care and yield greater patient satisfaction and lower costs, while maintaining high sensitivity and specificity. This review discusses common patient barriers to eye care, innovative approaches to retinal disease screening and monitoring using telemedicine, and eye care policy initiatives needed to enact large-scale telemedicine eye disease screening programs...
May 16, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28497987/elevated-activating-transcription-factor-4-and-glucose-regulated-78-kda-protein-levels-correlate-with-inflammatory-cytokines-in-the-aqueous-humor-and-vitreous-of-proliferative-diabetic-retinopathy
#2
Yanuo Wang, Sha Gao, Yanji Zhu, Xi Shen
PURPOSE: To determine concentrations of endoplasmic reticulum (ER) stress-related factors activating transcription factor 4 (ATF4) and glucose-regulated 78 kDa protein (GRP78) in vitreous and aqueous humor (AqH) of patients with proliferative diabetic retinopathy (PDR) and the correlation of ATF4, GRP78 and inflammatory cytokines interleukin-6(IL-6) and monocyte chemoattractant protein-1 (MCP-1). MATERIALS AND METHODS: AqH and vitreous samples were collected from eyes of patients with PDR and idiopathic macular hole (IMH) which needed vitrectomy...
May 12, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28494212/retinal-toxicity-of-acai-fruit-euterpe-oleracea-dye-concentrations-in-rabbits-basic-principles-of-a-new-dye-for-chromovitrectomy-in-humans
#3
Rafael R Caiado, Cristiane S Peris, Acácio Alves Souza Lima-Filho, Joao Guilherme Palma Urushima, Eduardo Novais, Emmerson Badaró, André Maia, Rita Sinigaglia-Coimbra, Sung Eun S Watanabe, Eduardo B Rodrigues, Michel Eid Farah, Mauricio Maia
PURPOSE: Evaluate toxicity of acai fruit (Euterpe oleracea) dye concentrations in a rabbit model. METHODS: Rabbits were injected intravitreously with 10%, 25%, and 35% acai dye concentrations. Control eyes received balanced salt solution (BSS). Electroretinogram (ERG), fundus imaging, fluorescein angiography (FA), optical coherence tomography (OCT), and light and transmission electron microscopy (LM/TEM) were performed. RESULTS: Fundus imaging showed increased vitreous opacity with increased dye concentrations...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28494168/uveal-melanoma-risk-factors-a-systematic-review-of-meta-analyses
#4
Taylor Nayman, Cristina Bostan, Patrick Logan, Miguel N Burnier
PURPOSE: There is currently no clinical risk-assessment tool allowing identification of patients at risk for developing uveal melanoma (UM) who might benefit from regular screening. As a first step toward the elaboration of such a tool, we systematically reviewed UM risk factors already established by meta-analysis. METHODS: Two reviewers independently screened Pubmed, Medline, Embase, and Web of Science from their respective inception dates until July 2016 using a combination of keywords and MeSH terms...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28494166/ocular-safety-of-intravitreal-connective-tissue-growth-factor-neutralizing-antibody
#5
Tahmineh Motevasseli, Narsis Daftarian, Mozhgan Rezaei Kanavi, Hamid Ahmadieh, Abouzar Bagheri, Seyed Bagher Hosseini, Shabnam Ansari, Zahra-Soheila Soheili
PURPOSE: To detect the safety of intravitreal injection of anti-connective tissue growth factor (CTGF) (IVAC) in rat eyes in order to apply this neutralizing antibody for experimental animal studies. METHODS: Forty-five Lister Hooded male pigmented rats were divided into five groups that received IVAC (2 μl) corresponding to the doses of 10 (B), 20 (C), 50 (D), and 100 μg/ml (E), equal to 1.25, 2.5, 6.25, and 12.5 µg/ml of antibody concentration in rat vitreous, respectively...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28494163/expression-of-14-3-3-zeta-protein-in-dexamethasone-treated-mice-and-human-tm-1-cells
#6
Qian Liu, Yiming Ye, Xianchai Lin, Yangfan Yang, Kaili Wu, Minbin Yu
PURPOSE: 14-3-3 zeta protein plays a potential protective role in neurodegenerative disease. Given that glaucoma and neurodegenerative diseases share a similar pathogenesis, it is possible that 14-3-3 zeta may have a similar protective effect in the glaucomatous process. In the present study, we measured the expression of 14-3-3 zeta in vivo (mouse eyes) and in vitro in a transformed human trabecular meshwork (HTM) cell line, TM-1, and assessed the possible roles of this protein in dexamethasone (DEX)-treated eyes and HTM cells...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28494159/association-of-visual-acuity-with-ocular-dominance-in-2045-myopic-patients
#7
Dan Zhou, Ni Ni, Aiping Ni, Qinjin Chen, Dan-Ning Hu, Jibo Zhou
PURPOSE: Previous studies of the relationship between visual acuity (VA) and ocular dominance have produced conflicting results. We hypothesized that (1) the discrepancies were related mostly to sample size and interocular visual acuity difference (IOVAD); (2) in large samples of individuals with marked IOVADs, the eye with the better uncorrected distance visual acuity (UDVA) would be dominant. These hypotheses were tested in a large group of myopic patients. METHODS: This prospective study of cycloplegic refraction involved 2045 myopic refractive surgery candidates...
May 11, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28443694/fractal-features-and-surface-micromorphology-of-unworn-surfaces-of-rigid-gas-permeable-contact-lenses
#8
Ştefan Ţălu, Miroslaw Bramowicz, Slawomir Kulesza, Ilenia Fiorillo, Stefano Giovanzana
PURPOSE: The aim of this exploratory study was to investigate the micromorphology of surfaces of rigid gas permeable (RGP) contact lenses (CLs) using atomic force microscopy (AFM) followed by fractal analysis. MATERIALS AND METHODS: In order to characterize in a quantitative manner the micromorphology of surfaces of new and unworn RGP CLs made of twelve different materials, AFM was taken and then analyzed using fractal methods. Surface topography was sampled in an intermittent-contact mode in air, on square areas of 5 × 5 µm(2) (MultiMode with Nanoscope V (Bruker)...
April 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441081/comparison-of-size-modulation-standard-automated-perimetry-and-conventional-standard-automated-perimetry-with-a-10-2-test-program-in-glaucoma-patients
#9
Kazunori Hirasawa, Natsumi Takahashi, Tsukasa Satou, Masayuki Kasahara, Kazuhiro Matsumura, Nobuyuki Shoji
PURPOSE: This prospective observational study compared the performance of size modulation standard automated perimetry with the Octopus 600 10-2 test program, with stimulus size modulation during testing, based on stimulus intensity and conventional standard automated perimetry, with that of the Humphrey 10-2 test program in glaucoma patients. METHODS: Eighty-seven eyes of 87 glaucoma patients underwent size modulation standard automated perimetry with Dynamic strategy and conventional standard automated perimetry using the SITA standard strategy...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441078/comparison-of-0-3-hypotonic-and-isotonic-sodium-hyaluronate-eye-drops-in-the-treatment-of-experimental-dry-eye
#10
Ying Li, Lian Cui, Hyo Seok Lee, Yeon Soo Kang, Won Choi, Kyung Chul Yoon
PURPOSE: To compare the efficacy of 0.3% hypotonic and isotonic sodium hyaluronate (SH) eye drops in the treatment of experimental dry eye. METHODS: Experimental dry eye was established in female C57BL/6 mice by subcutaneous scopolamine injection and an air draft. The mice were divided into three groups (n = 15): control, preservative-free 0.3% isotonic SH, and preservative-free 0.3% hypotonic SH. The tear volume, tear film break-up time, and corneal fluorescein staining scores were measured 5 and 10 days after treatment...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441077/comparison-of-conbercept-with-ranibizumab-for-the-treatment-of-macular-edema-secondary-to-branch-retinal-vein-occlusion
#11
Fengjiao Li, Ming Sun, Jianlian Guo, Aihua Ma, Bojun Zhao
PURPOSE: To confirm the therapeutic efficacy of conbercept for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: In this prospective, randomized, and comparative study, patients were randomized and divided into conbercept (n = 18) and ranibizumab (n = 17) groups. After an initial intravitreal injection of either conbercept or ranibizumab, a pro re nata (PRN) strategy was adopted based on loss of visual acuity (VA) or increase in central macular thickness (CMT)...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441071/efficacy-and-safety-of-23-gauge-pars-plana-vitrectomy-silicone-oil-tamponade-combination-for-treatment-of-pediatric-post-traumatic-endophthalmitis
#12
Wei Jin, Yaopeng Xu, Wenjun Wang, Yiqiao Xing, Anhuai Yang
PURPOSE: To determine (i) the etiology, epidemiology, mechanism of injury, and risk factors associated with open globe injuries (OGIs) in children and (ii) visual outcomes of pediatric patients with post-traumatic endophthalmitis following 23-gauge pars plana vitrectomy (PPV) combined with silicone oil tamponade (SOT). METHODS: A total of 107 consecutive patients, <15 years of age, who had been diagnosed with post-traumatic endophthalmitis between September 2009 and October 2015, were included in this 6-year retrospective study...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441067/anterior-segment-optical-coherence-tomography-angiography-for-identification-of-iris-vasculature-and-staging-of-iris-neovascularization-a-pilot-study
#13
Philipp K Roberts, Debra A Goldstein, Amani A Fawzi
Purpose/Aim of the study: To assess the ability of optical coherence tomographic angiography (OCTA) to visualize the normal iris vasculature as well as neovascularization of the iris (NVI). MATERIALS AND METHODS: Study participants with healthy eyes, patients at risk of NVI development and patients with active or regressed NVI were consecutively included in this cross-sectional observational study. Imaging was performed using a commercially available OCTA system (RTVue- XR Avanti, Optovue Inc...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28441060/characterization-of-a-standardized-ex-vivo-porcine-model-to-assess-short-term-intraocular-pressure-changes-and-trabecular-meshwork-vitality-after-pars-plana-vitrectomy-with-different-silicone-oil-and-bss-tamponades
#14
Martina Ebner, Siegfried Mariacher, José Hurst, Peter Szurman, Sven Schnichels, Martin S Spitzer, Kai Januschowski
PURPOSE: The aim of this study was to characterize a standardized porcine ex-vivo testing system for intraocular pressure (IOP) monitoring after vitrectomy with different endotamponades. METHODS: Twenty-four pig eyes, six per endotamponade group were obtained immediately postmortem. After pars plana vitrectomy, vitreous substitutes (silicone oil 1000 mPas, 2000 mPas, 5000 mPas, and Balanced Salt Solution (BSS)) were instillated and IOP was observed over 24-hours...
April 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28358253/comparison-of-accelerated-corneal-collagen-cross-linking-types-for-treating-keratoconus
#15
Yusuf Yıldırım, Onur Olcucu, Zehra Karaagac Gunaydin, Alper Ağca, Engin Bilge Ozgurhan, Cengiz Alagoz, Cagri Mutaf, Ahmet Demirok
PURPOSE: To compare the results of different protocols for accelerated corneal collagen cross-linking (CXL) in patients with progressive keratoconus. MATERIALS AND METHOD: This prospective comparative study involved 40 patients treated with intended UV-A radiance of 5.4 J/cm(2) in 74 eyes (Group 1) and 42 patients treated with radiance of 7.2 J/cm(2) in 72 eyes (Group 2). Visual acuity, subjective manifest refraction and corneal topography were analyzed before and 12 months after surgery in both groups...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28358247/negative-effects-of-acid-violet-17-and-mbb-dual-in-vitro-on-different-ocular-cell-lines
#16
José Hurst, Sven Schnichels, Martin S Spitzer, Karl-Ulrich Bartz-Schmidt, Marie-Louise Farecki, Peter Szurman, Kai Januschowski
PURPOSE: Vital dyes have become a clinical standard during vitrectomy to visualize anatomical structures. It was the aim of this study to test the effect of two vital dyes (AV 17-M with 5% mannitol and MBB Dual) on different intraocular cells, to see whether in vitro test can be used as reliable preclinical testing tool. METHODS: Cell morphology was assessed via phase contrast pictures, cell viability via MTS assay and total cell amount via crystal violet staining...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28358222/valacyclovir-as-initial-treatment-for-acute-retinal-necrosis-a-pharmacokinetic-modeling-and-simulation-study
#17
Tao Liu, Aabha Jain, Michael Fung, Christopher Vinnard, Vijay Ivaturi
PURPOSE: Acute retinal necrosis (ARN) is a feared complication of infectious retinitis most commonly caused by varicella zoster virus (VZV). We performed a pharmacokinetic modeling and simulation study by integrating the existing understanding of physiology with previously published data to evaluate the vitreal penetration of oral valacyclovir for the treatment of ARN, under various dosing scenarios. METHOD: We compared different oral valacyclovir dosing regimens with intravenous acyclovir...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28358220/vitreous-hyper-reflective-dots-in-optical-coherence-tomography-and-retinal-tear-in-patients-with-acute-posterior-vitreous-detachment
#18
Jong-Hyun Oh, Jaeryung Oh, Hyun Cheol Roh
PURPOSE: To report the presence of hyper-reflective dots in the vitreous cavity using spectral-domain optical coherence tomography (SD-OCT) in patients with acute symptomatic posterior vitreous detachment (PVD) and investigate their association with the presence of retinal tear. METHODS: The medical records of 77 patients with acute symptomatic PVD, who were examined between March 2013 and February 2015, were reviewed. The severity of vitreous hyper-reflective dots (VHDs) was graded using SD-OCT images, and the presence of retinal tear was assessed...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28358216/evaluation-of-the-safety-and-tolerability-of-conjunctival-ring-for-posterior-segment-of-the-eye
#19
Satoshi Kinoshita, Takeshi Ohguchi, Kousuke Noda, Miyuki Murata, Shin-Ichi Yasueda, Haruka Obata, Toru Matsunaga, Tsutomu Fukushima, Atsuhiro Kanda, Susumu Ishida
PURPOSE: To evaluate the safety and tolerability of conjunctival rings (CRs), a novel device for drug delivery to the posterior segment of the eye. METHODS: In animal studies, CRs containing 5% dexamethasone sodium phosphate (DSP) or vehicle solution were placed on the right and left eyes of C57BL/6J mice, respectively. Contact lenses (CLs) containing vehicle solution were used as a control. Twenty-four hours after placement of the CRs, corneal fluorescein staining was graded based on the McDonald-Shadduck scoring system, ranging from 0 to 4...
March 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28346009/reactions-with-antisera-and-pathological-effects-of-staphylococcus-aureus-gamma-toxin-in-the-cornea
#20
Michael A Bierdeman, Angela M Torres, Armando R Caballero, Aihua Tang, Richard J O'Callaghan
PURPOSE: This study analyzed the toxicity of purified gamma-toxin from Staphylococcus aureus and the protectiveness of antisera to gamma-toxin in the rabbit cornea. MATERIALS AND METHODS: Gamma-toxin was purified from cultures of alpha-toxin deficient S. aureus strain Newman Δhla. Antisera to native gamma-toxin (Hlg) were produced in rabbits. These antisera and a commercial polyclonal antibody to recombinant HlgB (rHlgB) were analyzed for specificity and toxin neutralization...
March 27, 2017: Current Eye Research
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