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Current Eye Research

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https://www.readbyqxmd.com/read/29240464/analysis-of-agreement-of-retinal-layer-thickness-measures-derived-from-the-segmentation-of-horizontal-and-vertical-spectralis-oct-macular-scans
#1
Natalia Gonzalez Caldito, Bhavna Antony, Yufan He, Andrew Lang, James Nguyen, Alissa Rothman, Esther Ogbuokiri, Ama Avornu, Laura Balcer, Elliot Frohman, Teresa C Frohman, Pavan Bhargava, Jerry Prince, Peter A Calabresi, Shiv Saidha
PURPOSE: Optical coherence tomography (OCT) is a reliable method used to quantify discrete layers of the retina. Spectralis OCT is a device used for this purpose. Spectralis OCT macular scan imaging acquisition can be obtained on either the horizontal or vertical plane. The vertical protocol has been proposed as favorable, due to postulated reduction in confound of Henle's fibers on segmentation-derived metrics. Yet, agreement of the segmentation measures of horizontal and vertical macular scans remains unexplored...
December 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199866/the-association-of-single-nucleotide-polymorphisms-in-the-mmp-9-gene-with-normal-tension-glaucoma-and-primary-open-angle-glaucoma
#2
Wool Suh, Hong-Hee Won, Changwon Kee
PURPOSE: To evaluate the association of matrix metalloproteinases (MMP)-9 gene polymorphisms with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) in the South Korean population. MATERIALS AND METHODS: A total of 700 South Korean subjects were recruited: 146 patients with NTG, 174 patients with POAG, and 380 healthy adults. Five single-nucleotide polymorphisms (SNPs; rs3918429, rs2274755, rs3787268, rs3918261, and rs3918270) of MMP-9 were analyzed in all subjects...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199865/changes-in-the-meibomian-gland-after-exposure-to-intense-pulsed-light-in-meibomian-gland-dysfunction-mgd-patients
#3
Yue Yin, Ninghua Liu, Lan Gong, Nan Song
PURPOSE: To observe (1) changes in meibomian gland (MG) after exposure to intense pulsed light (IPL) and (2) to understand the mechanism by which IPL treats meibomian gland dysfunction (MGD) in patients. METHODS: A cohort study, including 35 MGD patients, was conducted. IPL treatment was administered in one group (IPL group; n = 18), and eyelid hygiene in another (control group; n = 17) for 3 months. All patients were given artificial tears during the treatment period...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199864/intracameral-use-of-nepafenac-safety-and-efficacy-study
#4
Ramesh Jha, Vismapratap Sur, Arnab Bhattacharjee, Tanushri Ghosh, Vinod Kumar, Aditya Konar, Sarbani Hazra
PURPOSE: To test the intracameral safety of nepafenac and its efficacy in inhibiting prostaglandin synthesis during phacoemulsification surgery. METHODS: The safety evaluation was conducted in normal eyes of rabbits, 0.1ml of 0.3% and 1% nepafenac was injected intracamerally. Extensive studies to detect adverse response ranged from a gross examination of eyes under slit lamp biomicroscope, fluorescein dye test, Schirmer tear test, test for corneal sensitivity, intraocular pressure measurement (IOP), specular microscopy, electroretinography(ERG), and histopathological examination of intraocular tissues...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199863/optical-coherence-tomography-based-scattering-properties-of-retinal-vessels-in-glaucoma-patients
#5
Robert Kromer, Sebastian Boelefahr, Brendan Eck, Shafin Rahman, Maren Klemm
PURPOSE: Clinical trials have demonstrated that retinal blood flow deficiencies are present in patients with open-angle glaucoma (OAG). We introduce a method for facilitating retinal vessel analysis: The intensity of the distal shadow of vessels in optical coherence tomography (OCT) caused by the scattered signal is analyzed, compared between healthy subjects and OAG patients and correlated with OCT angiography (OCT-A) flow density. PATIENTS AND METHODS: We recruited 80 patients with diagnosed OAG (mean age 63...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199862/expression-of-sirt1-and-p53-in-rat-lens-epithelial-cells-in-experimentally-induced-dm
#6
Keke Xu, Shubin Wu, Zhijian Li, Hong Lou, Jiayu Yao, Hong Sun, Yin Sun, Yuxia Dai
PURPOSE: To determine the etiopathogenesis of diabetic cataract by studying changes in relative expressions of silent information regulator protein-1 (SIRT1) and P53 in rat lens epithelial cells (LECs) in experimentally induced diabetes mellitus (DM). METHODS: Six-week-old male SD rats (n = 120) were randomly divided into experimental (n = 80 rats) and control (n = 40 rats) groups. DM was induced in the experimental group (diabetic model) by intraperitoneal (i...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29199855/the-hierarchy-of-proinflammatory-cytokines-in-ocular-inflammation
#7
A P Da Cunha, Q Zhang, M Prentiss, X Q Wu, V Kainz, Y Y Xu, J Vrouvlianis, H Li, N Rangaswamy, B Leehy, T L McGee, C L Bell, C E Bigelow, V Kansara, Q Medley, Q Huang, H Y Wu
PURPOSE: The concept of tissue-dependent cytokine hierarchy has been demonstrated in a number of diseases, but it has not been investigated in ophthalmic diseases. Here, we evaluated the functional hierarchy of interleukin-1β (IL-1β), IL-6, IL-17A, and tumor necrosis factor (TNF) in the induction of ocular inflammation. MATERIALS AND METHODS: We delivered adeno-associated virus (AAV) vectors expressing IL-1β, IL-6, IL-17A, or TNF intravitreally in naïve C57/BL6 mice and compared and contrasted the inflammatory effects in the eye 5 weeks after AAV-mediated gene transfer...
December 4, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29190159/performance-of-bio-occlusive-dressing-as-barrier-protection-from-presurgical-chlorhexidine-skin-preparation
#8
Frank Brodie, Gregory Bever, David G Hwang
Purpose/Aim of the study: Chlorhexdine has been shown to provide excellent and cost-effective presurgical antisepsis. However, standard presurgical concentrations of chlorhexidine (2-4%) are known to cause ocular injury, even in cases in which a bio-occlusive dressing (Tegaderm™) was applied beforehand to the closed eye. MATERIALS AND METHODS: Three experiments were conducted to assess the barrier performance of Tegaderm™ to chlorhexidine skin prep in vitro and on non-ocular skin...
November 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29185816/measurements-of-retinal-nerve-fiber-thickness-and-ganglion-cell-complex-in-neurofibromatosis-type-1-with-and-without-optic-pathway-gliomas-a-case-series
#9
Nedime Sahinoglu-Keskek, Rana Altan-Yaycioglu, Handan Canan, Muge Coban-Karatas, Ayşe Erbay, Nalan Yazıcı, Ozlem Alkan
PURPOSE: The aim of this study was to investigate differences in retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses in neurofibromatosis 1 (NF1) cases, with and without optic pathway gliomas (OPGs). MATERIALS AND METHODS: In total, 33 eyes of 33 subjects were evaluated in this prospective observational case series. Twenty-one patients with a diagnosis of NF1 were enrolled. Patients with NF1 and OPGs were included in Group 1 (n = 9), and patients with NF1 without OPGs were included in Group 2 (n = 12)...
November 29, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29182404/evaluation-of-the-effect-of-everolimus-on-retinal-pigment-epithelial-cells-and-experimental-proliferative-vitreoretinopathy
#10
Hsi-Kung Kuo, Yi-Hao Chen, Yu-Hsia Kuo, Mu-Chan Ke, Ya-Chi Tseng, Pei-Chang Wu
PURPOSE: Failure of retinal detachment surgery is most commonly due to the development of proliferative vitreoretinopathy (PVR). Everolimus is an inhibitor of mammalian target of rapamycin (mTOR), and is available as oral tablets. In this study, we investigated the effect of everolimus on retinal pigment epithelial cells and modification of the severity of experimental PVR. METHODS: In our in vitro studies, primary culture of retinal pigment epithelium (RPE) cells was obtained from pigmented Rex rabbits...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29182401/the-association-of-cataract-and-lens-epithelial-cell-apoptosis-in-patients-with-pseudoexfoliation-syndrome
#11
Pembe Oltulu, Refik Oltulu
PURPOSE: The aim of this study was to measure the density of apoptotic lens epithelial cells (LECs) and to determine its association with cataract formation in eyes with pseudoexfoliation syndrome (PEX). MATERIALS AND METHODS: Twenty-one eyes of 21 patients diagnosed with PEX without glaucoma (Group 1) and 22 eyes of 22 subjects without PEX (Group 2) were enrolled in this study. During cataract surgery, anterior capsule samples were obtained by the 5.5 mm continuous curvilinear capsulorhexis method...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29172786/the-relationship-between-plasma-concentrations-of-lutein-and-zeaxanthin-with-self-reported-and-actual-prevalence-of-amd-in-an-irish-population-based-sample
#12
Rachel Moran, Stephen Beatty, Jim Stack, Aisling M O'Halloran, Joanne Feeney, Kwadwo O Akuffo, Tunde Peto, Rose Anne Kenny, John M Nolan
PURPOSE: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD). MATERIAL AND METHODS: Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System...
November 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29172741/effects-of-intravitreal-aflibercept-on-galectin-1-and-vascular-endothelial-growth-factor-a-plasma-levels-in-patients-with-diabetic-retinopathy
#13
Inga Waltl, Claus Zehetner, Christof Seifarth, Florian Handle, Gerhard F Kieselbach, Reinhard Angermann, Martina T Kralinger
PURPOSE: To analyze the interaction between aflibercept and galectin-1 and evaluate the plasma levels of galectin-1 and vascular endothelial growth factor (VEGF)-A after intravitreal injection of aflibercept in patients with diabetic retinopathy (DR). METHODS: Interaction of galectin-1 with aflibercept was determined via immunoprecipitation. Seventeen patients with type 2 diabetes and diabetic macular edema (DME) were each treated with a single intravitreal injection of aflibercept (2...
November 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29172736/role-of-glial-cells-in-%C3%AE-opioid-receptor-mediated-vasodilation-in-the-rat-retina
#14
Eriko Someya, Asami Mori, Daiki Asano, Akane Morita, Kenji Sakamoto, Tsutomu Nakahara
PURPOSE: Our recent study demonstrated that herkinorin, a non-opioid μ-receptor agonist derived from salvinorin A, dilates retinal arterioles through stimulation of μ-opioid receptors in rats. Activation of neuronal nitric oxide (NO) synthase and the presence of ganglion cells in the retina appear to be crucial for inducing μ-opioid receptor-mediated retinal vasodilation. In the present study, we examined the role of the interaction between neurons and glia in the retinal vasodilator mechanism involving μ-opioid receptors in rats...
November 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29172724/distribution-and-diversity-of-ocular-microbial-communities-in-diabetic-patients-compared-with-healthy-subjects
#15
Baknoon Ham, Hyung Bin Hwang, Sang Hoon Jung, Sungyul Chang, Kui Dong Kang, Man Jae Kwon
PURPOSE: The aim of this study was to identify differences in the major (core vs. variable) microbial genera of human subjects with and without diabetes. METHODS: Bacterial 16S rRNA genes obtained from conjunctival swabs of 19 healthy subjects and 30 diabetic patients were sequenced using the Illumina MiSeq platform, and the sequencing data were analyzed using QIIME 1.9.1. To elucidate the microbial diversity in the ocular surface (OS), test programs from various bioinformatics domains were used...
November 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29166180/measurement-of-orbital-biomechanical-properties-in-patients-with-thyroid-orbitopathy-using-the-dynamic-scheimpflug-analyzer-corvis-st
#16
Anna Leszczynska, Karolin Moehler, Eberhard Spoerl, Lisa Ramm, Robert Herber, Lutz E Pillunat, Naim Terai
PURPOSE: To investigate orbital biomechanical properties in patients with thyroid orbitopathy and in age- and gender-matched healthy subjects using the Corvis-ST (CST, Oculus Wetzlar, Germany). METHODS: The CST allows a non-contact tonometry with an ultra-high-speed Scheimpflug device to record the deformation of the cornea during an air pulse. Biomechanical response parameters (intraocular pressure (IOP), whole eye movement length (WEMl) and time (WEMt), deflection amplitude 2 mm ratio max, deflection amplitude max, stiffness parameter, and biomechanically corrected IOP were measured in 39 patients with thyroid orbitopathy (= group I) and in 33 age- and gender-matched healthy subjects (= group II) using the CST...
November 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29166145/effect-of-background-luminance-level-on-the-assessment-of-color-visual-acuity-using-colored-landolt-rings-in-young-healthy-subjects
#17
Yoshiki Tanaka, Sho Yokoyama, Rie Horai, Takashi Kojima, Sato Hiroyuki, Yukihito Kato, Mari Takagi, Hideki Nakamura, Kiyoshi Tanaka, Kazuo Ichikawa, Shoko Tanabe
PURPOSE: To evaluate the color visual acuity (CVA) of young healthy subjects using colored Landolt rings and the effect of background luminance level on the CVA. MATERIALS AND METHODS: We measured the CVA of 20 young healthy subjects (age: 23.8 ± 3.8 years) with different colors using a computer and a liquid crystal display, with 15 Landolt ring colors (30 cd/m(2)) with a background luminance of 30 cd/m(2), and then 100 cd/m(2). We then used different background luminance levels (15-50 cd/m(2)) using four Landolt ring colors (red, green-yellow, green, and blue-green) to evaluate the effect of the background luminance level on CVA...
November 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29166140/comparison-of-short-term-choroidal-thickness-and-retinal-morphological-changes-after-intravitreal-anti-vegf-therapy-with-ranibizumab-or-aflibercept-in-treatment-naive-eyes
#18
Magda Gharbiya, Rosalia Giustolisi, Jessica Marchiori, Alice Bruscolini, Fabiana Mallone, Valeria Fameli, Marcella Nebbioso, Solmaz Abdolrahimzadeh
PURPOSE: To evaluate choroidal thickness (CT) and retinal morphological changes in eyes with neovascular age-related macular degeneration (nAMD) following ranibizumab or aflibercept intravitreal treatment. MATERIALS AND METHODS: This was a prospective, observational, comparative study where 76 eyes of 76 consecutive patients with treatment-naive nAMD were consecutively enrolled and randomized to ranibizumab 0.5 mg or aflibercept 2 mg injections. Spectral-domain optical coherence tomography images of the choroid were obtained by enhanced depth imaging modality...
November 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29161162/patient-perceived-and-laboratory-measured-halos-associated-with-diffractive-bifocal-and-trifocal-intraocular-lenses
#19
Francisco Alba-Bueno, Nuria Garzón, Fidel Vega, Francisco Poyales, María S Millán
PURPOSE: To examine and assess the halos generated in distance vision by multifocal intraocular lenses (IOLs) using both in vitro objective and in vivo subjective methods. SETTING: The objective method was carried out in the optics laboratory of the Applied Optics and Image Processing Group (Universitat Politècnica de Catalunya -Barcelona). The psychophysical and subjective methods were carried out in the Instituto de Oftalmología Avanzada Madrid Innova Ocular...
November 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29161152/proliferative-cells-isolated-from-the-adult-human-peripheral-retina-only-transiently-upregulate-key-retinal-markers-upon-induced-differentiation
#20
Erik O Johnsen, Rebecca C Frøen, Ole Kristoffer Olstad, Bjørn Nicolaissen, Goran Petrovski, Morten C Moe, Agate Noer
Purpose/Aim: The adult human retina has limited regenerative potential, and severe injury will result in permanent damage. Lower vertebrates handle retinal injury by activating neural stem cells (NSCs) in the ciliary marginal zone (CMZ). Müller glia-like cells expressing markers of NSCs are also present in the peripheral retina (PR) of the adult human eye, leading to the hypothesis that a CMZ-like zone might exists also in humans. In order to shed further light on this hypothesis we investigated the in vitro differentiation potential of proliferative cells isolated from the adult human PR towards a retinal phenotype...
November 21, 2017: Current Eye Research
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