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Current Eye Research

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https://www.readbyqxmd.com/read/28339301/cultivation-of-human-oral-mucosal-explants-on-contact-lenses
#1
Barbara Zsebik, László Ujlaky-Nagy, Gergely Losonczy, György Vereb, Lili Takács
Purpose/Aim: Autologous cultivated oral mucosal (OM) epithelial transplantation has been successfully used as corneal epithelial replacement in bilateral limbal stem cell deficiency. Recently, lotrafilcon A contact lens (CL) surface was described as a suitable carrier for cultured stem cells in corneal epithelial transplantation. Our aim was to establish explant cultures from human OM on CL carriers that are free of animal-derived materials and feeder cells. MATERIALS AND METHODS: Human cadaveric 2 mm OM explants were sutured onto CL surfaces and cultivated with fetal calf serum (FCS) or human serum (HS) supplemented culture medium without feeder cells...
March 24, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28339297/long-term-effect-of-panretinal-photocoagulation-on-spectral-domain-optical-coherence-tomography-measurements-in-diabetic-retinopathy
#2
Haeng-Jin Lee, Tae-Seen Kang, Baek-Soo Kwak, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To evaluate the effects of panretinal photocoagulation on spectral domain optical coherence tomography measurements in diabetic retinopathy by comparing the thicknesses of the central macula, retinal nerve fiber layer, and ganglion cell layer, we used a Cirrus HD OCT® (Carl Zeiss Meditec, Dublin, CA, USA) in normal and diabetic retinopathy cohorts. METHODS: We analyzed patients who visited our retinal clinic between May 2013 and July 2014. The patients were classified into four groups: normal (Group A), diabetes without diabetic retinopathy (Group B), severe nonproliferative or proliferative diabetic retinopathy (Group C), and at least 3 years after panretinal photocoagulation treatment (Group D)...
March 24, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28328296/the-relationship-between-metabolic-syndrome-its-components-and-dry-eye-a-cross-sectional-study
#3
Sevil Karaman Erdur, Rukiye Aydin, Mustafa Ozsutcu, Oktay Olmuscelik, Mustafa Eliacik, Goktug Demirci, Mehmet Selim Kocabora
PURPOSE: The aim of this study was to evaluate tear osmolarity and tear film function and ocular surface changes in patients with metabolic syndrome. METHODS: 108 eyes of 64 patients with metabolic syndrome (group 1) and 110 eyes of 55 healthy individuals (group 2) were included in this cross-sectional study. All participants were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT), and tear osmolarity...
March 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28306392/effect-of-syringe-design-on-the-accuracy-and-precision-of-intravitreal-injections-of-anti-vegf-agents
#4
Elad Moisseiev, Jolene Rudell, Eric V Tieu, Glenn Yiu
PURPOSE: To evaluate the accuracy and precision of different syringe designs for intravitreal injection of anti-VEGF agents. METHODS: Volume output was measured from three syringe designs-1) 1.0 mL tuberculin syringe, 2) 1.0 mL syringe with low dead space plunger, and 3) 0.5 mL low-volume syringe-to deliver 50 µL of bevacizumab, ranibizumab, or aflibercept, each repeated four times by three different physicians for 108 total simulated injections. Volume output was calculated from difference in syringe weight before and after expelling the drug...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28306361/visual-field-progression-is-associated-with-systemic-concentration-of-macrophage-chemoattractant-protein-1-in-normal-tension-glaucoma
#5
Na Young Lee, Min Hee Kim, Chan Kee Park
PURPOSE: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG). METHODS: We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28306352/evaluation-of-the-tear-function-tests-and-the-ocular-surface-in-first-time-users-of-silicone-hydrogel-contact-lenses
#6
Yelda Yildiz Tasci, Canan Gürdal, Ozge Sarac, Aykut Onusever
PURPOSE: To evaluate the effects of three different silicone hydrogel contact lenses (SHCL), (balafilcon A, senofilcon A, and comfilcon A) on tear function tests, corneal thickness, and ocular surface cytology in first time contact lens users. MATERIALS AND METHODS: In this prospective study, 120 eyes of 60 subjects were evaluated. Balafilcon A users were designated as group 1, senofilcon A users as group 2, and comfilcon A users as group 3. In all cases, before and after 6 months of contact lens wear, ocular surface disease index score (OSDI), tear breakup time (TBUT), Schirmer 1 test, central corneal thickness (CCT), central corneal epithelium thickness (CCET), and conjunctival impression cytology samples were evaluated...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28306346/risk-factors-for-central-serous-chorioretinopathy-multivariate-approach-in-a-case-control-study
#7
Irini Chatziralli, Stamatina A Kabanarou, Efstratios Parikakis, Alexandros Chatzirallis, Tina Xirou, Panagiotis Mitropoulos
PURPOSE: The purpose of this prospective study was to investigate the potential risk factors associated independently with central serous retinopathy (CSR) in a Greek population, using multivariate approach. MATERIALS AND METHODS: Participants in the study were 183 consecutive patients diagnosed with CSR and 183 controls, matched for age. All participants underwent complete ophthalmological examination and information regarding their sociodemographic, clinical, medical and ophthalmological history were recorded, so as to assess potential risk factors for CSR...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28157425/clinical-features-and-prognostic-factors-in-presumed-ocular-tuberculosis
#8
Cristhian A Urzua, Yrbani Lantigua, Sergio Abuauad, Paulina Liberman, Osvaldo Berger, Pablo Sabat, Victor Velasquez, Enzo Castiglione, Margarita Calonge
PURPOSE: To characterize the clinical features in patients with presumed ocular tuberculosis (TB) and determine prognostic factors of visual outcomes and complications in this disease. MATERIAL AND METHODS: Retrospective case series of 35 patients (29 females, 6 males) with presumed ocular TB from referral centers in Chile and Spain between 2002 and 2012. Medical records were reviewed, and data regarding clinical features, complications, best-corrected visual acuity (BCVA), duration of disease, extraocular manifestations, and therapy were retrieved...
February 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28157410/short-term-vitreoretinal-tamponade-with-heavy-liquid-following-surgery-for-giant-retinal-tear
#9
Maya Eiger-Moscovich, Assaf Gershoni, Ruth Axer-Siegel, Dov Weinberger, Rita Ehrlich
PURPOSE: To study the efficacy and outcomes of short-term postoperative vitreoretinal tamponade with perfluorocarbon heavy liquid in patients with giant retinal tear. MATERIALS AND METHODS: The study group consisted of 13 consecutive patients (13 eyes) who presented with giant retinal tear at a tertiary medical center in 2011-2015 and were treated with vitrectomy followed by short-term tamponade with perfluorocarbon heavy liquid. A minimum of 3 months' follow-up was required for inclusion...
February 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28139163/comparison-of-autologous-serum-versus-preservative-free-artificial-tear-in-patients-with-dry-eyes-due-to-systemic-isotretinoin-therapy
#10
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Enes Gökler
PURPOSE: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease. METHOD: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28139159/light-induced-retinopathy-young-age-protects-more-than-ocular-pigmentation
#11
Anna Polosa, Hyba Bessaklia, Pierre Lachapelle
PURPOSE: The purpose of this study was to compare the efficacy that ocular melanin confers in protecting the retina of juvenile and adult rats exposed to a bright luminous environment. METHODS: Juvenile (JLE) and adult (ALE) Long-Evans pigmented rats were thus exposed to a bright cyclic light (10,000lux; white light) from postnatal day 14-28 or for 6 consecutive days, respectively. Flash electroretinograms (ERG) and retinal histology were performed at different predetermined ages, post-light exposure...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28139154/safety-and-efficacy-of-a-membrane-tube-type-glaucoma-shunt-device-an-animal-trial
#12
Dai Woo Kim, Young Hoon Hwang, Byung Heon Ahn, Eun-Kyung Lee, Chang-Sik Kim
PURPOSE: To evaluate the safety and efficacy of a membrane-tube-type glaucoma shunt device (MT-device), which was developed to control intraocular pressure (IOP) with a lower chance of complications than conventional glaucoma surgery, in a rabbit model. MATERIALS AND METHODS: The MT-device consists of an expanded polytetrafluoroethylene membrane (thickness 0.2 mm, area 2.5 × 2.5 mm(2)) and a tube (internal diameter 76 µm, external diameter 175.5 µm, length 7 mm) attached to the membrane...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28139150/efficacy-of-purtscher-s-retinopathy-treatments-a-systematic-review
#13
Duosheng Xia, Xiaomei Chen, Qi Zhou, Shujun Xiao, Yang Yu, Yadong Wang, Gang Du, Haixiang Huang, Wenfang Zhang, Yaolong Chen
OBJECTIVE: The aim of this review is to evaluate the efficacy of available Purtscher's Retinopathy treatments. MATERIALS AND METHODS: In order to collect single-case reports, electronic searches were conducted in several databases including PubMed, Embase, Web of Science, China National Knowledge Infrastructure, SinoMed, VIP, and WanFang in the Electronic Theses and Dissertations Center. In VIP and Wanfang, we also traced the references of included articles. Risk of bias was evaluated using a tool adapted from the Cochrane Risk of Bias Tool...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28139142/relation-between-ocular-comfort-arachidonic-acid-mediators-and-histamine
#14
Simin Masoudi, Zhenjun Zhao, Mark Willcox
PURPOSE: Contact lenses are associated with discomfort during wear. This may be the result of stimulation of the ocular surface and production of pro-inflammatory mediators which are then released into the tears. This study examined changes in the concentration in tears of arachidonic acid metabolites (AAM) prostaglandins, cysteinyl leukotrienes, and resolvin-D1, as well as histamine in a general contact lens population in the morning and evening. METHOD: Tears were collected twice a day (morning and evening) for up to 10 days on two different occasions (with and without contact lens wear) from 30 experienced contact lens wearers for analysis of AAM and a separate group (N = 33) for analysis of histamine...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28129001/association-between-migraine-and-dry-eye-disease-a-nationwide-population-based-study
#15
Soonwon Yang, Woojun Kim, Hyun Seung Kim, Kyung-Sun Na
PURPOSE: Despite the possible association between migraine and dry eye disease (DED), there are only a few studies investigating this link in a relatively limited number of patients. Therefore, we have analyzed the relationship between migraine and DED in the Korean population. MATERIALS AND METHODS: This population-based cross-sectional study included 14 329 adults participating in the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2012...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28129000/dry-eye-symptoms-patient-reported-visual-functioning-and-health-anxiety-influencing-patient-satisfaction-after-cataract-surgery
#16
Ildikó Szakáts, Margit Sebestyén, Éva Tóth, György Purebl
PURPOSE: To evaluate how patient satisfaction after cataract surgery is associated with postoperative visual acuity, visual functioning, dry eye signs and symptoms, health anxiety, and depressive symptoms. PATIENTS AND METHODS: Fifty-four patients (mean age: 68.02 years) were assessed 2 months after uneventful phacoemulsification; 27 were unsatisfied with their postoperative results and 27 were satisfied. They completed the following questionnaires: Visual Function Index-14 (VF-14), Ocular Surface Disease Index (OSDI), Shortened Health Anxiety Inventory (SHAI), and Shortened Beck Depression Inventory...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28128997/roasting-enhances-the-anti-cataract-effect-of-coffee-beans-ameliorating-selenite-induced-cataracts-in-rats
#17
Nana Ishimori, Jun Oguchi, Yosuke Nakazawa, Kenji Kobata, Megumi Funakoshi-Tago, Hiroomi Tamura
PURPOSE: Coffee is a widely consumed beverage. While recent studies have linked its intake to a reduced risk of cataracts, caffeine is believed to be the key factor for its effect. To know how roasting beans affects the effect of coffee on cataract formation, we investigated the impact roasting using a selenite-induced cataract rat model. MATERIALS AND METHODS: Sprague Dawley rats were given a single injection of sodium selenite, which induced formation of nuclear cataracts by day 6, with or without coffee intake (100% coffee, 0...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28128986/comparison-of-intravitreal-bevacizumab-intravitreal-ranibizumab-and-laser-photocoagulation-for-treatment-of-type-1-retinopathy-of-prematurity-in-turkish-preterm-children
#18
Emrah Utku Kabataş, Bengi Ece Kurtul, Pınar Altıaylık Özer, Naciye Kabataş
PURPOSE: To evaluate effectiveness of treatment modalities, major complications and refractive errors in children who were treated with intravitreal bevacizumab (IVB), intravitreal ranibizumab (IVR) or laser photocoagulation (LP) for type 1 retinopathy of prematurity (ROP). METHODS: Premature infants who underwent IVB monotherapy (Group 1), IVR monotherapy (Group 2) or LP (Group 3) for type 1 ROP and infants with spontaneously regressed ROP (Group 4) were included for the study...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28128981/development-and-assessment-of-a-novel-canine-ex-vivo-corneal-model
#19
Laura R Proietto, R David Whitley, Dennis E Brooks, Gregory E Schultz, Daniel J Gibson, William M Berkowski, Marc E Salute, Caryn E Plummer
PURPOSE: To develop a novel ex vivo extended culture model of canine corneal epithelial cell wound healing. MATERIALS AND METHODS: Canine corneoscleral rims (CSR) were obtained and, after preparation for culture, were placed on a nutating scaffold and incubated in physiological conditions. In experiment 1, eight CSR in a serum-containing antimicrobial-fortified medium were monitored for epithelial integrity and bacterial infection up to 28 days in culture. CSR were assessed histologically at the end of the culture period end points 0, 7, 14, and 28 days with accompanying scanning electron microscopic (SEM) and transmission electron microscopic (TEM) evaluation...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28121186/goldmann-applanation-tonometry-versus-dynamic-contour-tonometry-after-vitrectomy-with-silicone-oil-endotamponade
#20
Matthias Fuest, Nikolaos Mamas, Peter Walter, Babac E Mazinani, Gemot Roessler, Niklas Plange
PURPOSE: To evaluate the agreement of intraocular pressure (IOP) measurements using dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in eyes after vitrectomy with silicone oil endotamponade and controls. METHODS: In this prospective comparative study, IOP was measured with GAT and DCT in 30 eyes with oil endotamponade 1-3 days after vitrectomy and 40 untreated controls. In addition, ocular pulse amplitude (OPA), corneal pachymetry (CCT), and axial length (AL) were measured...
January 25, 2017: Current Eye Research
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