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Current Eye Research

K B Garbutcheon-Singh, N Carnt, U Pattamatta, C Samarawickrama, A White, V Calder
AIM: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. One of the key pro-inflammatory cytokines is IL-17, and it has been investigated in order to facilitate the understanding of the pathogenesis of ocular surface lesion development...
September 19, 2018: Current Eye Research
Signe Krejberg Jeppesen, Toke Bek
PURPOSE: Dual wavelength retinal oximetry allows the quantification of oxygen saturation in the larger retinal vessels. However, the technique might be refined further by identifying factors that are responsible for the different oxygen saturations in first order arterioles from the same eye shortly after their branching from the central retinal artery. The purpose of the present study was to investigate whether these factors involve rheological characteristics in the studied vessels...
September 19, 2018: Current Eye Research
Xiao Lin, Rajeev K Naidu, Jinhui Dai, Xingtao Zhou, Xiaomei Qu, Hao Zhou
Background This study aims to assess the efficacy of the scleral collagen cross-linking method using glyceraldehyde solution for prevention of lens-induced axial elongation in New Zealand rabbits, and investigate the biochemical and microstructural changes that occur. Methods The right eyes of New Zealand rabbits aged seven weeks were randomly divided into three groups: the cross-linking group (n = 6), non-crosslinking group (n = 5), and untreated control group (n = 5). Eyes in cross-linking and non-crosslinking groups were treated with a -8...
September 17, 2018: Current Eye Research
Ho Ra, Won Ki Lee
PURPOSE: The aim of the present study was to evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique that involved the use of a perfluorocarbon liquid (PFCL) bubble for the selective prevention of indocyanine green (ICG) staining of the parts of the inverted flap in contact with the retinal pigment epithelium for large macular hole (MH) closure. MATERIALS AND METHODS: This retrospective, interventional, comparative study included 26 patients with idiopathic large MHs (minimum diameter, > 400 µm) who underwent vitrectomy using the inverted ILM flap technique with conventional ILM staining with ICG (n = 14, Group 1) or PFCL-mediated selective ILM staining with ICG (n = 12, Group 2)...
September 14, 2018: Current Eye Research
Ruby K Prakasam, Aline Götze, Sophie Von Keyserlingk, Anselm Jünemann, Martin Röhlig, Oliver Stachs, Dagmar-C Fischer
OBJECTIVE: Children with chronic kidney diseases (CKD) are at risk for neurological diseases at early adulthood. Spectral-domain optical coherence tomography (SD-OCT) of the retina is especially suitable for determination of intraretinal layer thickness. We wonder whether retinal thinning is already present in pediatric patients with mild-to-moderate CKD. PATIENTS AND METHODS: Children (n = 15; 14.9 ± 2.4 years) with mild-to-moderate CKD (median eGFR of 95ml/min/1...
September 11, 2018: Current Eye Research
Yasemi Masoud, Salouti Ramin, Razmkhah Mahboobeh, Maalhagh Mehrnoosh, Javidi Fahimeh, Kariminejad Parastoo
PURPOSE: The effects of lithium (Li) and Valproic Acid (VA) drugs have been recently revealed to improve the Mesenchymal stem cells')MSCs (migration and proliferation processes. The aim of this study is to determine the expression of the genes involved in the proliferation and migration of limbal epithelial stem/progenitor cells (LESPCs) after treatment with Li and VA. METHODS: After extraction of LSCs from human Corneoscleral tissue, cells were subcultured to 3 times...
September 11, 2018: Current Eye Research
María Cinta Puell, María Jesús Pérez-Carrasco, Catalina Palomo-Álvarez
Purpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident early age-related macular degeneration (AMD) This study examines relationships between macular thickness measurements and photopic or mesopic VA in healthy eyes. MATERIALS AND METHODS: In 38 young and 39 older healthy individuals, total, inner and outer retinal layer (IRL and ORL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT). Measurements were made across three subfields centered at the fovea: central foveal, pericentral and peripheral...
September 10, 2018: Current Eye Research
Guihua Liu, Nan Jin, Hua Bi, Bei Du, Tianpu Gu, Bin Zhang, Ruihua Wei
PURPOSE: To map the time course of changes in intraocular straylight of the human eye 1 year after initial lens wearing for orthokeratology treatment using the objective double-pass technique. MATERIALS AND METHODS: A total of 35 subjects (19 males and 16 females) completed the study. The mean age was 11.46 ± 2.33 years (range, 8-16 years). All subjects were fitted with spherical four-zone orthokeratology lenses following the procedures recommended by the lens manufacturer...
September 10, 2018: Current Eye Research
Chan Yun Kim, Sangah Kim, Hyoung Won Bae, Chan Keum Park, Kwanghyun Lee, Sang Yeop Lee, Gong Je Seong
PURPOSE: This study aims to develop a nomogram to predict brain lesions in patients with complete or incomplete bitemporal hemianopia by combining results from optical coherence tomography (OCT) and visual field (VF) testing. MATERIAL AND METHODS: We reviewed the medical records of patients who underwent magnetic resonance imaging (MRI) to identify brain lesions due to bitemporal hemianopia between January 2010 and March 2017, retrospectively. The patients were divided into two groups based on MRI findings: brain-lesion (+) group that had brain lesions on MRI (n = 63), and brain-lesion (-) group without brain lesions on MRI (n = 16)...
September 10, 2018: Current Eye Research
Mohammad Harun-Or-Rashid, Finn Hallböök
PURPOSE: Alpha 2-adrenergic receptor (α2-ADR) agonists are used clinically for a range of indications including reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Animal experiments show that α2-ADR agonists attenuate the injury-induced Müller cell dedifferentiation by a mechanism that involves activation and regulation of extracellular signal-regulated kinase (ERK) 1/2 leading to transactivation of epidermal growth factor receptors (EGFRs)...
September 10, 2018: Current Eye Research
Hassan Hashemi, Soheila Asgari, Shiva Mehravaran, Mohammad Hassan Emamian, Akbar Fotouhi
PURPOSE: To compare 5-year changes of central and peripheral corneal thickness, corneal volume, and keratometry between diabetic and non-diabetic individuals (>40 years) in a population-based study. MATERIALS AND METHODS: Right eye corneal indices of the 333 diabetic persons were compared with 2865 non-diabetics. Studied indices included the apical corneal thickness (ACT), minimal corneal thickness (MCT), thickness values on corneal rings of 4 mm, 6 mm, and 8 mm in diameter, the volume of the 10 mm of the corneal diameter, and the central 3 mm keratometry in two steep (Kmax) and flat (Kmin) axes as measured with Pentacam (Oculus, Inc, Lynnwood, WA)...
September 10, 2018: Current Eye Research
Wei Zhang, Yingxue Ma, Yue Zhang, Jing Yang, Guanghui He, Song Chen
PURPOSE: Age-related macular degeneration (AMD) is a major cause of blindness in the elderly, and the activation of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome is involved in AMD pathogenesis. We investigated whether photooxidative blue-light stimulation in retinal pigment epithelium (RPE) cells promotes exosome secretion and modulates the activity of the NLRP3 inflammasome in vitro. METHODS: Exosomes were isolated from ARPE-19 cultures stimulated or not with blue-light photostimulation (488 nm)...
September 10, 2018: Current Eye Research
Tao Wang, Xiao-Yan Wei, An-An Yang, Zhao Liu, Shi-Qi Wang, Yi-Yan You, Fang Kuang, Si-Wei You, Ming-Mei Wu
PURPOSE: This study's aim was to investigate the beneficial effects of branched-chain amino acids (BCAAs) on the neuronal survival and axon regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) transection. METHOD: The experimental rats received daily BCAA injections through the caudal vein after left intra-orbital ON transection. Neuroprotection was evaluated by counting Fluorogold-labeled RGCs. The role of mammalian target of rapamycin (mTOR) pathway activation in promoting RGC survival was studied after rapamycin administration...
September 10, 2018: Current Eye Research
Mehtap Caglayan, Sucattin Ilker Kocamıs, Ozge Sarac, Hayriye Tatli Dogan, Pinar Kosekahya, Murat Ayan, Nurullah Cagil
PURPOSE: To compare heme oxygenase 2 (HO-2) enzyme levels detected by immunohistochemical staining methods in the cornea epithelium obtained from keratoconus patients and normal subjects. MATERIALS AND METHODS: The keratoconus group included 69 eyes of 69 patients with keratoconus scheduled for cross-linking surgery. The control group included 52 eyes of 52 patients with refractive error scheduled for photorefractive keratectomy surgery. After a detailed ophthalmologic examination, corneal topographic maps of each patient were generated, and then the patients underwent surgery...
September 9, 2018: Current Eye Research
Qingchen Li, Hao Wang, Peng Gao
PURPOSE: To assess the visual function in patient with myopic foveoschisis (MF). METHODS: Fifty-one eyes of 51 subjects were enrolled and divided into myopic foveoschisis group (MFG, N = 16), myopic control group (MCG, N = 18), and normal control group (NCG, N = 17) according to their diagnoses. Measurements of the logarithm of the minimum angle of resolution (LogMAR), the objective scatter index (OSI), the cut-off value of modulation transfer function (COMTF), the Strehl ratio (SR), the foveal threshold (FT), and the amplitude density (AD) in the first central ring of multifocal electroretinography were recorded and compared amongst groups...
September 5, 2018: Current Eye Research
Mazyar Yazdani, Xiangjun Chen, Behzod Tashbayev, Øygunn A Utheim, Sten Ræder, Neil Lagli, Aleksandar Stojanovic, Darlene A Dartt, Tor P Utheim
PURPOSE: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. METHODS: Patients (n = 1090) with DED of different etiologies received an extensive dry eye work-up: osmolarity (Osm), tear meniscus height (TMH), tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), and meibum quality (MQ)...
September 5, 2018: Current Eye Research
Carol Ann Greene, Stuti Lonie Misra, Hannah Lee, James McKelvie, Kushant Kapadia, Robin McFarlane, Charles Ninian John McGhee, Colin Richard Green, Trevor Sherwin
PURPOSE: The aim of this study was to perform qualitative and quantitative analyses to characterize the corneas of young, healthy sheep. MATERIALS AND METHODS: Eight healthy male sheep, 10 months to 1 year of age, were included as experimental subjects. Central corneal thickness was measured using a handheld pachymeter, and an Easygraph corneal topographer provided topographic maps. Microstructural imaging of corneal layers was achieved by using the Heidelberg Retina Tomograph III Rostock Corneal Module in vivo corneal microscope (IVCM)...
August 23, 2018: Current Eye Research
Yongrong Ji, Changxin Lai, Lixu Gu, Xianqun Fan
PURPOSE OF THE STUDY: This study was to establish a three-dimensional (3D) coordinate system and to study the normal dimensions of intra-orbital structures in Chinese adults. MATERIALS AND METHODS: One hundred and forty-five adult Chinese were selected from patients who had undergone cranio-facial computed tomography scans with diagnosis other than orbital or ocular abnormality. An orbital 3D coordinate system was built on the basis of the scans. Morphological variables of intra-orbital structures were measured in this coordinate system...
August 17, 2018: Current Eye Research
Friederike Lindemann, David Kuerten, Eva Koch, Matthias Fuest, Claudia Fischer, Andreas Voss, Niklas Plange
PURPOSE: Vascular dysfunction and ischemia are believed to play an important part in the pathogenesis of glaucoma and especially of normal tension glaucoma (NTG). The aim of the present study was to analyze the blood pressure (BP) and heart rate variability patterns in patients with primary open-angle glaucoma (POAG) and NTG compared with controls. METHODS: In total, 37 patients with POAG, 27 patients with NTG, and 82 control subjects were included in a prospective clinical validation study...
August 15, 2018: Current Eye Research
Jan Darius Unterlauft, Matus Rehak, Peter Wiedemann, Petra Meier
PURPOSE: Firework devices cause high numbers of eye trauma cases each year worldwide. These can range from mild conjunctival irritation to devastating loss of all vision or the organ itself. A systematic 10-year retrospective monocentric case analysis was the main aim of this study. MATERIALS AND METHODS: All firework-associated eye trauma patients treated in our clinic from 2007 to 2017 were grouped for trauma severity and analyzed for influencing factors like age, gender, laterality, final visual acuity, and ocular trauma score (OTS)...
August 15, 2018: Current Eye Research
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