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Current Eye Research

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https://www.readbyqxmd.com/read/28985098/retinal-nerve-fiber-layer-thickness-in-human-t-cell-lymphotropic-virus-type-1-patients
#1
Harold Merle, Rabih Hage, Séverine Jeannin, Philippe Cabre, Stéphane Olindo
PURPOSE: To determine whether there is an optic neuropathy (ON) in patients with human T-cell lymphotropic virus type 1 (HTLV-1) infection. METHODS: We included HTLV-1 asymptomatic carriers (a.c.HTLV-1) and tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) patients between January 1st, 2014 and March 31st, 2015. All patients had complete eye examination. The visual acuity (VA) and retinal nerve fiber layer (RNFL) thickness were measured and compared to age- and sex-matched control groups including patients seen in our refraction clinic with no previous medical or surgical history...
October 6, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28985092/resveratrol-ameliorates-retinal-ischemia-reperfusion-injury-in-c57bl-6j-mice-via-downregulation-of-caspase-3
#2
Hyemin Seong, Jinhyun Ryu, Woong-Sun Yoo, Seong Jae Kim, Yong-Seop Han, Jong Moon Park, Sang Soo Kang, Seong Wook Seo
PURPOSE: Ischemia/reperfusion (I/R) injury induces apoptosis in retinal ganglion cells (RGCs). Resveratrol (Res) is a potent natural antioxidant with beneficial effects in many ocular diseases, such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Because caspase-3 expression is highly correlated with activation of the apoptotic pathway, the present study aimed to determine whether Res regulates the expression of caspase-3 using an I/R retinal injury mouse model...
October 6, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28985087/dr-gerd-geerling-editor-current-eye-research
#3
Charles W McMonnies
No abstract text is available yet for this article.
October 6, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28972410/apoa-i-mimetic-peptide-4f-reduces-age-related-lipid-deposition-in-murine-bruch-s-membrane-and-causes-its-structural-remodeling
#4
Martin Rudolf, Armin Mir Mohi Sefat, Yoko Miura, Aysegül Tura, Walter Raasch, Mahdy Ranjbar, Salvatore Grisanti, Zouhair Aherrahrou, Anna Wagner, Jeffrey D Messinger, David W Garber, G M Anantharamaiah, Christine A Curcio
PURPOSE: Accumulation of lipoprotein-derived lipids including esterified and unesterified cholesterol in Bruch's membrane of human eyes is a major age-related change involved in initiating and sustaining soft drusen in age-related macular degeneration (AMD). The apolipoprotein (apo) A-I mimetic peptide 4F is a small anti-inflammatory and anti-atherogenic agent, and potent modifier of plasma membranes. We evaluated the effect of intravitreally-injected 4F on murine Bruch's membrane. METHODS: We tested single intravitreal injections of 4F doses (0...
October 3, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28956656/a-method-for-volumetric-retinal-tissue-oxygen-tension-imaging
#5
Anthony E Felder, Justin Wanek, Pang-Yu Teng, Norman P Blair, Mahnaz Shahidi
PURPOSE: Inadequate retinal oxygenation occurs in many vision-threatening retinal diseases, including diabetic retinopathy, retinal vascular occlusions, and age-related macular degeneration. Therefore, techniques that assess retinal oxygenation are necessary to understand retinal physiology in health and disease. The purpose of the current study is to report a method for the three-dimensional (3D) imaging of retinal tissue oxygen tension (tPO2) in rats. METHODS: Imaging was performed in Long Evans pigmented rats under systemic normoxia (N = 6) or hypoxia (N = 3)...
September 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28956644/the-evaluation-of-retinal-and-choroidal-structural-changes-by-optical-coherence-tomography-in-patients-with-chronic-obstructive-pulmonary-disease
#6
Mustafa Gok, Murat Atabey Ozer, Serkan Ozen, Berna Botan Yildirim
PURPOSE: To evaluate the retinal nerve fiber layer (RNFL) thickness, ganglion cell-inner plexiform layer (GCL+) thickness, and macular choroidal thickness (mCT) in patients with chronic obstructive pulmonary disease (COPD) using spectral domain optical coherence tomography (SD-OCT). METHODS: A total of 79 COPD patients and 71 age- and sex-matched healthy individuals were enrolled in this prospective cross-sectional study. The patients were divided into two subgroups (with mild-to-moderate COPD and severe COPD) using spirometric data suggested by the Global Initiative for Chronic Obstructive Lung Disease guideline...
September 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937877/changes-in-peripapillary-nerve-fiber-layer-thickness-after-adjuvant-stereotactic-radiotherapy-in-patients-with-neovascular-age-related-macular-degeneration
#7
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
PURPOSE: To evaluate the effect of stereotactic radiotherapy (SRT) in conjunction with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs on peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with neovascular age-related macular degeneration (nAMD). METHODS: This was a retrospective, observational case series of patients with nAMD, who underwent SRT and subsequently had at least 12 months of complete follow-up...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#8
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937875/multiplex-cytokine-analysis-of-aqueous-humor-from-the-patients-with-chronic-primary-angle-closure-glaucoma
#9
Roopam Duvesh, George Puthuran, Kavitha Srinivasan, Venkatesh Rengaraj, S R Krishnadas, Sharmila Rajendrababu, Vijayakumar Balakrishnan, Pradeep Ramulu, Periasamy Sundaresan
PURPOSE: To compare the levels of cytokines and growth factor in aqueous humor of the patients with chronic primary angle closure glaucoma (PACG) and cataract. METHODS: Aqueous humor samples were collected from 19 chronic PACG patients and compared with 14 nonglaucomatous controls presenting for cataract surgery. The levels of 27 cytokines and growth factors were measured in the aqueous samples using multiplex bead immunoassay and compared across groups. RESULTS: Significantly higher levels of interleukin (IL)-8 (p < 0...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937872/protective-effect-of-combined-caffeic-acid-phenethyl-ester-and-bevacizumab-against-hydrogen-peroxide-induced-oxidative-stress-in-human-rpe-cells
#10
Erdem Dinc, Lokman Ayaz, Akif Hakan Kurt
PURPOSE: This study aimed to evaluate the protective effects of caffeic acid phenethyl ester (CAPE) and combined CAPE-bevacizumab against oxidative stress induced by hydrogen peroxide (H2O2) in human retinal pigment epithelium. METHODS: ARPE-19 cells were pretreated with 5, 10, and 30 μM CAPE alone and in combination with bevacizumab for 3 h, then exposed to H2O2 for 16 h. Cell viability was evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937869/effect-of-microtubule-disruption-on-dynamics-of-acidic-organelles-in-the-axons-of-primary-cultured-retinal-ganglion-cells
#11
Seiji Miyake, Yuji Takihara, Satoshi Yokota, Yoshihiro Takamura, Masaru Inatani
PURPOSE: Axonal transport is fundamental to autophagy in neuronal cells. To understand its biological significance in various conditions, it is necessary to monitor the process of autophagy. However, monitoring methods are often limited to static analyses, such as protein expression and histological observations. Autophagy has multistep process and is highly dynamic; therefore, additional techniques are necessary to study autophagy. In this study, we quantified the dynamics of autophagy-related organelle transport under conditions of dynamic instability and catastrophic disruption of microtubules using in vitro live imaging...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937867/coenzyme-q10-for-the-protection-of-lacrimal-gland-against-high-dose-radioiodine-therapy-associated-oxidative-damage-histopathologic-and-tissue-cytokine-level-assessments-in-an-animal-model
#12
Mehmet Yakin, Umit Eksioglu, Murat Sadic, Gokhan Koca, Guner Ozkan-Uney, Nihat Yumusak, Hande Husniye Telek, Ayten Demir, Nuray Yazihan, Firdevs Ornek, Meliha Korkmaz
PURPOSE: To evaluate protective effect of coenzyme Q10 (CoQ10) in lacrimal glands against high-dose radioactive iodine (RAI)-associated oxidative damage. MATERIALS AND METHODS: Thirty Wistar albino rats were randomly divided into three groups. Group 1 was the control group. Group 2 received 3 mCi/kg RAI via gastric gavage but no medication. Group 3 received 3 mCi/kg RAI via gastric gavage and 30 mg/kg/day CoQ10 intraperitoneally. CoQ10 was started at day one just before RAI administration and continued for five days...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937866/soluble-vascular-adhesion-protein-1-mediates-spermine-oxidation-as-semicarbazide-sensitive-amine-oxidase-possible-role-in-proliferative-diabetic-retinopathy
#13
Miyuki Murata, Kousuke Noda, Akiko Kawasaki, Shiho Yoshida, Yoko Dong, Michiyuki Saito, Zhenyu Dong, Ryo Ando, Shohei Mori, Wataru Saito, Atsuhiro Kanda, Susumu Ishida
Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: The levels of soluble VAP-1/SSAO and the unsaturated aldehyde acrolein (ACR)-conjugated protein, N(ε)-(3-formyl-3, 4-dehydropiperidino) lysine adduct (FDP-Lys), were measured in vitreous fluid samples of PDR and non-diabetic patients using ELISA...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937859/choroidal-thickness-in-traumatic-optic-neuropathy
#14
Ju-Yeun Lee, Doo-Ri Eo, Kyung-Ah Park, Sei Yeul Oh
PURPOSE: To examine the choroidal thickness in patients with indirect traumatic optic neuropathy (TON) Methods: Patients with unilateral traumatic optic neuropathy over a period of 4 years were included in this study. Horizontal and vertical enhanced-depth imaging (EDI) from spectral-domain optical coherence tomography (SD-OCT) scans of the fovea were obtained in patients with unilateral TON within 2 weeks of injury. The main outcome measure was the choroidal thickness at nine locations...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937857/evaluation-of-retinal-blood-flow-before-and-after-panretinal-photocoagulation-using-pattern-scan-laser-for-diabetic-retinopathy
#15
Yoshihisa Yamada, Kiyoshi Suzuma, Naoko Onizuka, Masafumi Uematsu, Yasser Helmy Mohamed, Takashi Kitaoka
PURPOSE: Laser speckle flowgraphy (LSFG) can measure blood flow in the ocular fundus. We analyzed the relationship between retinal blood flow and panretinal photocoagulation (PRP) in diabetic retinopathy. METHODS: This retrospective observational study examined the eyes of 35 patients with proliferative diabetic retinopathy (PDR) or non-PDR (NPDR). PRP was performed using a pattern scan laser. Using LSFG, blood flow was evaluated as the mean blur rate (MBR) or the relative flow volume (RFV)...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937835/protective-effect-of-sulforaphane-against-retinal-degeneration-in-the-pde6-rd10-mouse-model-of-retinitis-pigmentosa
#16
Kai Kang, Minzhong Yu
PURPOSE: Retinitis pigmentosa (RP) is a group of inherited diseases characterized by the death of rod photoreceptors, followed by the death of cone photoreceptors, progressively leading to partial or complete blindness. Currently no specific treatment is available for RP patients. Sulforaphane (SFN) has been confirmed to be an effective antioxidant in the treatment of many diseases. In this study, we tested the therapeutic effects of SFN against photoreceptor degeneration in Pde6b(rd10) mice...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937833/oct-angiography-for-monitoring-and-managing-neovascular-age-related-macular-degeneration
#17
P Malamos, G Tsolkas, M Kanakis, G Mylonas, D Karatzenis, N Oikonomopoulos, J Lakoumentas, Ilias Georgalas
PURPOSE: To evaluate the combined use of optical coherence tomography and angiography (OCT-A) for imaging choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration (nAMD). MATERIALS AND METHODS: This prospective observational study was conducted from May 2015 to April 2017. Included in the study were 54 patients (n = 63 eyes), all of whom had CNV secondary to nAMD and all of whom had been examined by OCT-A. Angioscans (3x3 and 6 × 6) and conventional B-scan OCT scans were obtained for all patients at baseline and at various times during the 24-month follow-up period...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937831/impact-of-smoking-on-the-ocular-surface-tear-function-and-tear-osmolarity
#18
Serdar Aktaş, Mehmet Tetikoğlu, Ahmet Koçak, Metin Kocacan, Hatice Aktaş, Hacı Murat Sağdık, Fatih Özcura
PURPOSE: This study evaluated the effects of cigarette smoking on the ocular surface, tear function, and tear osmolarity. MATERIALS AND METHODS: A total of 50 smokers with at least 5 years of heavy smoking (defined as 1 pack/day) and 51 nonsmoking, healthy individuals were enrolled. Tear osmolarity was measured with an osmometer (TearLab(™) Osmolarity System). Ocular surface examinations involved corneal fluorescein staining, measurement of the tear film breakup time (TBUT), the Schirmer 1 test, measurement of corneal sensitivity with a Cochet-Bonnet esthesiometer, and conjunctival impression cytology...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937830/simvastatin-as-an-adjunct-to-conventional-therapy-of-non-infectious-uveitis-a-randomized-open-label-pilot-study
#19
Ivan V Shirinsky, Anastasia A Biryukova, Valery S Shirinsky
PURPOSE: Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvastatin in patients with uveitis. METHODS: For this single-center, open-label, randomized study, we enrolled patients with acute non-infectious uveitis...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937828/the-effects-of-systemic-alfuzosin-and-tamsulosin-hydrochloride-on-choroidal-thickness-and-pupil-diameter-sizes-in-cases-with-benign-prostatic-hyperplasia
#20
Mustafa Dogan, Bunyamin Kutluksaman, Ibrahim Keles, Mustafa Karalar, Ahmet Omer Halat
PURPOSE: To compare the effects of alfuzosin hydrochloride and tamsulosin hydrochloride on choroidal thickness (CT) and pupil diameter (PD) sizes in patients with benign prostatic hyperplasia. SUBJECTS AND METHODS: Sixty-three men patients with newly diagnosis of benign prostatic hyperplasia were randomly assigned to either alfuzosin hydrochloride or to tamsulosin hydrochloride groups in this prospective, randomized, parallel-group clinical trial. Enhanced depth imaging spectral-domain optical coherence tomography, pupillography were obtained at baseline, 1st and 3rd month, and choroidal thicknesses and pupil diameter sizes were compared between the two groups...
September 22, 2017: Current Eye Research
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