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Current Eye Research

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https://www.readbyqxmd.com/read/27897453/clinical-usefulness-of-simultaneous-measurement-of-the-tear-levels-of-ccl17-ccl24-and-il-16-for-the-biomarkers-of-allergic-conjunctival-disorders
#1
Jun Shoji, Hiroshi Aso, Noriko Inada
PURPOSE: This study investigated the clinical usefulness of a multiple tear cytokine/chemokine test by simultaneously determining tear levels of CC chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC), CCL24/eotaxin-2, and interleukin-16 (IL-16) for assessing acute and chronic allergic inflammation in allergic conjunctival disorders (ACDs). SUBJECTS AND METHODS: This study included 37 patients with ACD and 11 healthy adults (controls). Patients with ACDs were divided into the following three groups; patients with allergic conjunctivitis (AC group, n = 17), patients with atopic keratoconjunctivitis (AKC group, n = 6), and patients with vernal keratoconjunctivitis (VKC group, n = 14)...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897448/diagnostic-ability-of-automated-pupillography-in-glaucoma
#2
Harsha L Rao, Sujatha V Kadambi, Pooja Mehta, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Dhanraj A S Rao, Rohit Shetty
PURPOSE: To evaluate the diagnostic ability of automated pupillography measurements in glaucoma and study the effect of inter-eye asymmetry in glaucomatous damage on the diagnostic ability. METHODS: In an observational, cross-sectional study, 47 glaucoma patients and 42 control subjects underwent automated pupillography using a commercially available device. Diagnostic abilities of the pupillary response measurements were evaluated using area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897443/evaluation-of-biochemical-composition-of-vitreous-of-eyes-of-diabetic-patients-using-proton-magnetic-resonance-spectroscopy
#3
Ilke Bahceci Simsek, Ozgur Artunay
PURPOSE: To investigate possible metabolic changes in vitreous of patients with diabetes mellitus with or without diabetic retinopathy using proton magnetic resonance spectroscopy. MATERIAL AND METHODS: Twenty-eight healthy control subjects (group 1), 18 patients with diabetes mellitus without diabetic retinopathy (group 2) and 18 patients with diabetic retinopathy (group 3) were included. Proton magnetic resonance spectroscopy was performed in left vitreous of all subjects; amounts of Glutamate, Choline, Lactate and Creatine values were measured...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897442/pupillary-offset-in-keratoconus-and-its-relationship-with-clinical-and-topographical-features
#4
Gozde Hondur, Nurullah Cagil, Ozge Sarac, Meltem Ece Ozcan, Pinar Kosekahya
PURPOSE: To evaluate the change in the location of pupillary center with corneal tomography in keratoconic patients, and determine the correlation of pupillary offset with clinical and topographical features of keratoconus. METHODS: Ninety-one eyes of the 54 patients with keratoconus in different stages and 39 eyes of 39 refractive surgery candidates with normal corneas were included in our study. Ocular aberrations and the pupillary offset parameters (x-offset and y-offset) over a 5 mm (undilated) pupil were measured with a Sirius corneal tomographer...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27897441/effects-of-molsidomine-on-retinopathy-and-oxidative-stress-induced-by-radiotheraphy-in-rat-eyes
#5
Murat Atabey Özer, Nihat Polat, Serkan Özen, Hakan Parlakpınar, Kemal Ekici, Alaaddin Polat, Nigar Vardı, Kevser Tanbek, Azibe Yildiz
PURPOSE: To determine the role of Molsidomine in preventing radiation-induced retinopathy after head and neck region irradiation of rats with a single radiation dose of 15 Gy. MATERIALS AND METHODS: Male Wistar albino rats were randomly grouped into five as follows: (1) control group rats, which were applied through an intraperitoneal (i.p.) vehicle without radiotherapy (RT); (2) RT group rats received a single dose of 15 Gy irradiation and after daily 0.1 ml vehicle i...
November 29, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27870590/dry-eye-disease-in-patients-with-newly-diagnosed-depressive-disorder
#6
Nesime Setge Tiskaoglu, Alper Yazıcı, Tunay Karlıdere, Esin Sari, Elif Yilmaz Oguz, Musa Musaoglu, Seyda Aslan, Sıtkı Samet Ermiş
PURPOSE: Psychiatric conditions and not just the treatments themselves might be involved in the pathophysiology of dry eye disease (DED). The aim of our study was to evaluate the association between depression and DED using objective and subjective tests in patients with newly diagnosed depressive disorder who were not using any medication which may help us to determine the sole effect of depression on dry eye. METHODS: Thirty-six patients from the psychiatry clinic with a new diagnosis of depressive disorder and 32 controls were included in the study...
November 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27854142/effects-of-mitomycin-c-in-early-conjunctival-inflammation-after-pterygium-surgery
#7
Claudia da Costa Paula, Gemma Julio, Pamela Campos, Pere Pujol, Mouafk Asaad
PURPOSE: The purpose of this study was to compare inflammatory events and graft characteristics 1 month and 6 months after conjunctival limbal autograft (CLAU) with and without intraoperative mitomycin C (MMC). METHODS: This study included 69 eyes of 69 patient's eyes with pterygium. Clinical data concerning patient demography, preoperative examination including pterygium morphology, recurrence clinical assessment, and complications after CLAU with (MMC+) and without (MMC-) intraoperative MMC were all registered at 1 month and 6 months after surgery...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27854139/foveal-layer-morphology-detected-on-spectral-domain-optical-coherence-tomography-and-its-correlation-with-visual-acuity-in-asian-indian-premature-infants-in-their-first-year-of-life
#8
Chaitra Jayadev, Anand Vinekar, Shwetha Mangalesh, Mathew Kurian Kummelil, Anupama Kiran Kumar, Vasudha Kemmanu, Munusamy Sivakumar, Padmamalini Mahendradas, Kavitha Avadhani, Noel Bauer, Carroll Ab Webers, Bhujang Shetty
PURPOSE: To report foveal microanatomy imaged on handheld spectral domain optical coherence tomography (SDOCT) and correlate it with visual acuity in Asian Indian premature infants. METHODS: A retrospective analysis of 32 Asian Indian premature infants, 10 with Type 2 retinopathy of prematurity (ROP), were imaged between 3 and 12 months of corrected postmenstrual age (PMA) on the handheld SDOCT (Envisu 2300, Bioptigen, DNC, USA). The foveal findings on these images were correlated with visual acuity measured using Teller acuity cards...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27854132/changes-of-retinal-nerve-fiber-layer-thickness-in-obstructive-sleep-apnea-syndrome-a-systematic-review-and-meta-analysis
#9
Wei Wang, Miao He, Wenyong Huang
PURPOSE: Many studies have assessed the changes of retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS), but the results were inconsistent. Therefore, a meta-analysis was performed to evaluate the RNFL changes in OSAS measured in vivo. METHODS: Pertinent studies were identified by a comprehensive search of PubMed, Embase, Web of science, Cochrane library, Scopus, and Chinese biomedical disc databases from inception to August 2016...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27854124/25-gauge-vitrectomy-with-epiretinal-membrane-and-internal-limiting-membrane-peeling-in-eyes-with-very-good-visual-acuity-author-reply
#10
Elad Moisseiev, Joseph Moisseiev
No abstract text is available yet for this article.
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27854122/the-relationship-of-brimonidine-concentration-in-vitreous-body-to-the-free-concentration-in-retina-choroid-following-topical-administration-in-pigmented-rabbits
#11
Keisuke Shinno, Kazuya Kurokawa, Seiko Kozai, Akio Kawamura, Katsuhiro Inada, Hideki Tokushige
PURPOSE: Several studies showed that repeated topical administration of brimonidine tartrate ophthalmic solution reached the human vitreous concentration above 2 nM, which is the concentration necessary to activate the α2-adrenergic receptor. The purpose of this study was to elucidate the relationship of the brimonidine concentration in the vitreous body to the free concentration in the retina/choroid which is the target site of brimonidine on neuroprotective effect after topical administration...
November 17, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27791408/evaluation-of-meibomian-gland-dysfunction-in-polycystic-ovary-syndrome-and-obesity
#12
Gonen Baser, Nurdan Yildiz, Mehmet Calan
: Purpose/Aim of the study: The purpose of this study was to evaluate the interaction between Polycystic ovary syndrome (PCOS) and Meibomian gland dysfunction (MGD) and obesity, to reveal whether there is a correlation between the testosterone levels and body-mass index (BMI) levels and the dry-eye complaints of these patients. MATERIAL AND METHODS: The study included 92 patients with PCOS and 52 healthy patients from March 2013 to March 2014. All patients underwent a physical examination, pelvic ultrasound, and clinical and biochemical tests, including free testosterone levels to confirm the diagnosis of PCOS...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27791404/comment-on-25-gauge-vitrectomy-with-epiretinal-membrane-and-internal-limiting-membrane-peeling-in-eyes-with-very-good-visual-acuity
#13
Abdullah Kaya
No abstract text is available yet for this article.
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27791390/immediate-effect-of-3-diquafosol-ophthalmic-solution-on-tear-muc5ac-concentration-and-corneal-wetting-ability-in-normal-and-experimental-keratoconjunctivitis-sicca-rat-models
#14
Kwang-Eon Choi, Jong-Suk Song, Boram Kang, Youngsub Eom, Hyo-Myung Kim
PURPOSE: To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS: Rats were divided into normal and KCS groups. 3% of diquafosol solution was instilled into the right eye and normal saline into the left eye in both groups. To determine the peak time of tear MUC5AC concentration, tears were collected after 3% diquafosol instillation every 5 min up to 20 min...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27791387/changes-in-the-properties-and-organization-of-human-lens-lipid-membranes-occurring-with-age
#15
Laxman Mainali, Marija Raguz, William J O'Brien, Witold K Subczynski
PURPOSE: This research was undertaken to document the changes in the organization and properties of human lens lipid membranes that occur with age. METHODS: Human lens lipid membranes prepared from the total lipids extracted from clear lens cortices and nuclei of donors from age groups 0-20 and 21-40 years were investigated. An electron paramagnetic resonance technique and nitroxide spin labels (analogues of phospholipids and cholesterol) were used. RESULTS: Two distinct lipid domains, the phospholipid-cholesterol domain (PCD) and the pure cholesterol bilayer domain (CBD), were detected in all investigated membranes...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27767373/autoregulation-of-optic-nerve-head-blood-flow-induced-by-elevated-intraocular-pressure-during-vitreous-surgery
#16
Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka, Takatoshi Maeno
PURPOSE: To investigate optic nerve head (ONH) blood flow changes resulting from intraocular pressure (IOP) elevation in subjects without systemic disorders. MATERIALS AND METHODS: Eighteen eyes of 18 patients who underwent vitrectomy to treat an epiretinal membrane or macular hole at Toho University Sakura Medical Center were included. Following standard 25-gauge microincision vitreous surgery, mean blur rate (MBR) in tissue (MT), an index of ONH blood flow, was measured using laser speckle flowgraphy...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27767360/a-novel-approach-to-analyze-the-progression-of-measured-corneal-sub-basal-nerve-fiber-length-in-continuously-expanding-mosaic-images
#17
Stephan Allgeier, Karsten Winter, Georg Bretthauer, Rudolf F Guthoff, Sabine Peschel, Klaus-Martin Reichert, Oliver Stachs, Bernd Köhler
: Purpose/Aim of the study: A recently proposed technique enables the generation of continuously increasing mosaic images of the corneal sub-basal nerve plexus (SNP) using in vivo corneal confocal microscopy (CCM). The aim of the present study was to investigate the progression of the corneal nerve fiber length (CNFL) measured in the growing mosaic images with regard to their increasing area. MATERIALS AND METHODS: Five large datasets from three healthy volunteers were examined using the proposed CCM technique...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27767357/laser-vision-correction-with-q-factor-modification-for-keratoconus-management
#18
Natasha Kishore Pahuja, Rohit Shetty, Abhijit Sinha Roy, Maithil Mukesh Thakkar, Chaitra Jayadev, Rudy Mma Nuijts, Harsha Nagaraja
PURPOSE: To evaluate the outcomes of corneal laser ablation with Q factor modification for vision correction in patients with progressive keratoconus. METHODS: In this prospective study, 50 eyes of 50 patients were divided into two groups based on Q factor (>-1 in Group I and ≤-1 in Group II). All patients underwent a detailed ophthalmic examination including uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), subjective acceptance and corneal topography using the Pentacam...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27767354/long-term-efficacy-of-orthokeratology-contact-lens-wear-in-controlling-the-progression-of-childhood-myopia
#19
Jacinto Santodomingo-Rubido, César Villa-Collar, Bernard Gilmartin, Ramón Gutiérrez-Ortega, Keiji Sugimoto
PURPOSE: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. METHODS: Subjects 6-12 years of age with myopia -0.75 to -4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance single-vision spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period...
October 21, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27767345/bayer-filter-snapshot-hyperspectral-fundus-camera-for-human-retinal-imaging
#20
Joel Kaluzny, Hao Li, Wenzhong Liu, Peter Nesper, Justin Park, Hao F Zhang, Amani A Fawzi
PURPOSE: To demonstrate the versatility and performance of a compact Bayer filter snapshot hyperspectral fundus camera for in-vivo clinical applications including retinal oximetry and macular pigment optical density measurements. METHODS: 12 healthy volunteers were recruited under an Institutional Review Board (IRB) approved protocol. Fundus images were taken with a custom hyperspectral camera with a spectral range of 460-630 nm. We determined retinal vascular oxygen saturation (sO2) for the healthy population using the captured spectra by least squares curve fitting...
October 21, 2016: Current Eye Research
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