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Current Eye Research

Louis Tong, Lim Shee Teng
Purpose/aims: Dry eye is a common multi-factorial disease characterized by tearfilm dysfunction. Diagnosis of dry eye requires documentation of tear status with non-invasive tear break up times (NIBUT), tear meniscal height (TMH), and tearfilm lipid layer. These parameters objectively assess tear stability and indirectly, the functional impact of meibomian gland dysfunction. While it is obvious that portable instrumentation gives broader access than fixed instrumentation, its value would be limited if it is unreliable and its precision and accuracy substantially worse than fixed instruments...
February 16, 2018: Current Eye Research
Yo Iwata, Tomoya Handa, Hitoshi Ishikawa, Toshiaki Goseki, Nobuyuki Shoji
PURPOSE: In recent years, amblyopia treatment device that can be used with both eyes open have been reported. The Occlu-pad is a device that can present images of tablet terminals to one eye only under binocular open conditions. Till date, no study has reported the effectiveness of Occlu-pad training for anisometropic amblyopia in a series of cases. In the present study, we evaluated the effectiveness of the Occlu-pad for the management of anisometropic amblyopia without the use of occlusion therapy (eyepatch)...
February 16, 2018: Current Eye Research
Masaaki Yoshida, Shiho Kunimatsu-Sanuki, Kazuko Omodaka, Toru Nakazawa
PURPOSE: This study aimed to calculate a predicted integrated visual field (IVF) based on predicted monocular visual fields (MVFs) derived, with a new method, from wide-scan optical coherence tomography (OCT) data. MATERIALS AND METHODS: Visual field testing used the central (6 × 4) 24 points of the Humphrey Field Analyzer 24-2 program. OCT scans of a corresponding retinal area, centered on the fovea, were divided into a 6 × 4 grid. The thickness of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCIPL), and mRNFL + GCIPL (GCC) was measured in each grid area...
February 16, 2018: Current Eye Research
Stefan A Kassumeh, Christian M Wertheimer, Annabel von Studnitz, Anna Hillenmayer, Claudia Priglinger, Armin Wolf, Wolfgang J Mayer, Daniel Teupser, Lesca M Holdt, Siegfried G Priglinger, Kirsten H Eibl-Lindner
PURPOSE: Posterior capsule opacification (PCO) still represents the main long-term complication of cataract surgery. Research into pharmacologic PCO prophylaxis is extensive. One promising candidate drug is methotrexate (MTX). Our aim is to determine the in vitro feasibility of MTX-loaded poly(lactic-co-glycolic) (PLGA) biomatrices sprayed on intraocular lenses (IOLs) as a drug-delivery implant. METHODS: Hydrophilic and hydrophobic acrylic IOLs were spray-coated with MTX-loaded PLGA...
February 16, 2018: Current Eye Research
Je Moon Woo, Yo Sep Yoon, Jong Eun Woo, Jung Kee Min
PURPOSE: To investigate foveal avascular zone (FAZ) area after surgery in patients with rhegmatogenous retinal detachment (RRD) that involved or uninvolved the macula, and to evaluate the correlation between FAZ area and visual outcomes using swept-source optical coherence tomography angiography (OCTA). MATERIALS AND METHODS: This retrospective case-control study included 34 eyes (34 patients) with recent onset RRD that were successfully repaired with a single, uncomplicated surgical procedure (pars plana vitrectomy with gas tamponade)...
February 16, 2018: Current Eye Research
Wei Wang, Miao He, Xingwu Zhong
PURPOSE: The purpose of this study is to determine the influence of sex on choroidal thickness (CT) in healthy adults. METHODS: Healthy Chinese adults were recruited and complete ophthalmic examinations were performed. The choroid was imaged by swept-source optical coherence tomography and the macular CT in Early Treatment Diabetic Retinopathy Study grids was obtained by the intrinsic automated segmentation software. CT in males and females was compared after controlling other factors...
February 16, 2018: Current Eye Research
Rodolfo Mastropasqua, Luca Agnifili, Enrico Borrelli, Vincenzo Fasanella, Lorenza Brescia, Luca Di Antonio, Leonardo Mastropasqua
PURPOSE: To analyze the retinal radial peripapillary capillary (RPC) network in normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) eyes using optical coherence tomography angiography (OCTA). MATERIAL AND METHODS: Twenty-two patients with NTG, 22 patients with unilateral chronic NAION, and 23 age-matched controls were enrolled. Patients underwent OCTA to obtain en face angiograms of the peripapillary region. The main outcome measures were as follows: (1) the whole en face image perfusion density (WPD) and (2) the circumpapillary perfusion density (CPD)...
February 16, 2018: Current Eye Research
Ewa Kosior-Jarecka, Joanna Bartosińska, Urszula Łukasik, Dominika Wróbel-Dudzińska, Dorota Krasowska, Grażyna Chodorowska, Tomasz Żarnowski
The aim of the study was to evaluate the results of nailfold videocapillaroscopic examination in patients with normal-tension glaucoma (NTG) in comparison to age-matched individuals without glaucoma and young healthy volunteers and to assess the relation between the results of this examination with clinical status in NTG group. MATERIAL AND METHODS: The studied group consisted of 188 patients: 80 patients with NTG and 2 control groups (58 young healthy and 50 age-matched volunteers). The nailfold videocapillaroscopy (NVC) was performed in all participants...
February 16, 2018: Current Eye Research
Emina Čolak, Lepša Žorić, Aleksandra Radosavljević, Svetlana Ignjatović
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD...
February 15, 2018: Current Eye Research
Paul J Bonezzi, Maureen E Stabio, Jordan M Renna
PURPOSE: Photoreceptors in the mouse retina express much of the molecular machinery necessary for phototransduction and glutamatergic transmission prior to eye opening at postnatal day 13 (P13). Light responses have been observed collectively from rod and cone photoreceptors via electroretinogram recordings as early as P13 in mouse, and the responses are known to become more robust with maturation, reaching a mature state by P30. Photocurrents from single rod outer segments have been recorded at P12, but no earlier, and similar studies on cone photoreceptors have been done, but only in the adult mouse retina...
February 15, 2018: Current Eye Research
Hyun Jin Shin, Shin-Hyo Lee, Kang-Jae Shin, Ki-Seok Koh, Wu-Chul Song
AIMS: To elucidate the intramuscular distribution and branching patterns of the abducens nerve in the lateral rectus (LR) muscle so as to provide anatomical confirmation of the presence of compartmentalization, including for use in clinical applications such as botulinum toxin injections. METHODS: Thirty whole-mount human cadaver specimens were dissected and then Sihler's stain was applied. The basic dimensions of the LR and its intramuscular nerve distribution were investigated...
February 15, 2018: Current Eye Research
Dragana Škiljić, Anne Petersen, Jan-Olof Karlsson, Anders Behndig, Staffan Nilsson, Madeleine Zetterberg
PURPOSE: Protective effects of estradiol against H2O2-induced oxidative stress have been demonstrated in lens epithelial cells. The purpose of this study was to investigate the effects of 17β-estradiol (E2) on the different superoxide dismutase (SOD) isoenzymes, SOD-1, SOD-2, and SOD-3, as well as estrogen receptors (ERs), ERα and ERβ, in primary cultured human lens epithelial cells (HLECs). MATERIALS AND METHODS: HLECs were exposed to 0.1 µM or 1 µM E2 for 1...
February 12, 2018: Current Eye Research
Michael Kinori, Iliana Molina, Eric O Hernandez, Shira L Robbins, David B Granet, Anne L Coleman, Stuart I Brown
PURPOSE: To compare the performance of the PlusoptiX S12 mobile photoscreener and the Retinomax K+3 Autorefractor as screening devices in preschool children. METHODS: Children ranging from 3 to 5 years of age from 11 San Diego County preschools underwent vision screening in their schools where ambient light could not always be controlled using both the Retinomax and the PlusoptiX. Cycloplegic refraction on the consented children was subsequently performed on the UCSD EyeMobile for children on-site at the school locations...
February 9, 2018: Current Eye Research
Somin Ahn, Youngsub Eom, Boram Kang, Jungboung Park, Hyung Keun Lee, Hyo Myung Kim, Jong Suk Song
PURPOSE: To evaluate the effects of menthol-containing artificial tears on tear stimulation and ocular surface integrity in normal and dry eye rat models. METHODS: A total of 54 male Lewis rats were used. The levels of tear secretion and tear MUC5AC concentrations were compared between the menthol-containing artificial tear-treated group (menthol group) and the vehicle-treated group (vehicle group). The groups were compared after a single instillation to evaluate the immediate effects, and after repeated instillation (five times a day for 5 days) to evaluate the longer-term effects...
February 8, 2018: Current Eye Research
Kyoung Woo Kim, Jung Huh, Soo Jin Lee, Sung Po Kim, Eung Bae Kim, Jae Chan Kim
PURPOSE: The amniotic membrane (AM) is the transparent innermost layer of the placenta and it facilitates rapid wound healing in a diversity of ocular surface disorders. However, extended periods of cryopreservation before use induce significant impairment of cell viability due to oxidative stresses and inflammatory responses. We investigated the effect of supplementing ulinastatin (ULI), a known serine protease inhibitor, and relevant mechanisms of action in AM preservation solution through the hypothermic continuum on inflammatory and apoptotic signals and viability of AM tissue...
February 5, 2018: Current Eye Research
Roman Paduch, Anna Matysik-Woźniak, Ryszard Maciejewski, Anselm G Jünemann, Robert Rejdak
Purpose/Aim of the study: The corneal and conjunctival epithelium interact with each other and reciprocally modulate the levels of soluble mediators to maintain balance in the ocular surface. The aim of the present study was to analyze paracrine interactions between the corneal and conjunctival epithelium in an inflamed microenvironment (LPS or PMA induction) to test the levels of pro- and anti-inflammatory cytokines and nitric oxide released by the epithelia. MATERIALS AND METHODS: The corneal (pRSV-T) and conjunctival (HC0597) epithelial cell cultures and their indirect co-cultures were treated for 2 h with LPS (E...
February 5, 2018: Current Eye Research
Ahmed Abass, John Clamp, FangJun Bao, Renato Ambrósio, Ahmed Elsheikh
PURPOSE: To investigate the prevalence of non-orthogonal astigmatism among normal and keratoconic Brazilian and Chinese populations. METHODS: Topography data were obtained using the Pentacam High Resolution (HR) system ® from 458 Brazilian (aged 35.6 ± 15.8 years) and 505 Chinese (aged 31.6 ± 10.8 years) eyes with no history of keratoconus or refractive surgery, and 314 Brazilian (aged 24.2 ± 5.7 years) and 74 Chinese (aged 22.0 ± 5.5 years) keratoconic eyes...
February 2, 2018: Current Eye Research
Maria Markoulli, Amanda Sobbizadeh, Jacqueline Tan, Nancy Briggs, Minas Coroneo
PURPOSE: To evaluate the impact of Optive (Allergan, Irvine, CA) and Optive Advanced (Allergan, Irvine, CA) on tear film stability and quality during a one-hour observation period when compared to saline (Pfizer, Perth, WA). METHODS: This was a double-masked, cross-over study. Twenty participants attended three visits, randomly receiving either Optive, Optive Advanced or saline. Oculus Keratograph 5M (Oculus, Arlington, WA, USA), non-invasive keratograph break-up time (NIKBUT), Lipiview (TearScience Inc, Morrisville, NC, USA), lipid layer thickness (LLT) and comfort were measured prior to and 5, 15 and 60 min after drop instillation...
February 1, 2018: Current Eye Research
Jingjing You, Luis Munoz-Erazo, Li Wen, Chris Hodge, Michele C Madigan, Gerard Sutton
PURPOSE: Limbal corneal epithelial cells (LCECs) are responsible for corneal epithelial cell regeneration. However, corneal central epithelial cells (CCECs) are also suggested to display potential for self-renewal. Additionally, a better understanding of molecules that regulate corneal epithelial cell regeneration is important for studying conditions affecting the cornea, for example, keratoconus. Given our previous findings of reduced levels of secreted frizzled-related protein 1 (SFRP1) in tears from keratoconus patients compared to controls, we investigated the effects of SFRP1 on the proliferation and survival of cultured central and limbal human corneal epithelial cells...
January 30, 2018: Current Eye Research
Annekatrin Rickmann, Peter Szurman, Sacha Jung, Karl Thomas Boden, Silke Wahl, Arno Haus, Katrin Boden, Kai Januschowski
PURPOSE: To compare the clinical outcomes following Descemet's membrane endothelial keratoplasty (DMEK) with 100% air tamponade versus 10% sulfur hexafluoride (SF 6 ) tamponade. METHODS: Retrospective analysis of 108 consecutive DMEK cases subdivided by anterior chamber tamponade with 54 eyes receiving 10% SF 6 and 54 eyes receiving 100% air injection. A post-hoc matched analysis revealed no statistically significant differences between the groups. The main outcome measurements were the complication rate, including intra- and postoperative complications and graft detachment rate requiring re-bubbling...
January 29, 2018: Current Eye Research
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