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Current Eye Research

Juanjuan Li, Yunpeng Li, Hua Li
OBJECTIVE: The aim of this study was to investigate the multimodality imaging features of retinal cavernous hemangiomas (RCHs). MATERIALS AND METHODS: The clinical data of three patients with RCH were reviewed and the imaging findings were analyzed. RESULTS: The color photographs of the fundus showed bead-like vesicles in the retina. Some vesicles showed plasma erythrocyte separation-with plasma on the top and erythrocytes at the bottom-which was consistently detected as high spontaneous fluorescence on fundus fluorescence angiography...
November 15, 2018: Current Eye Research
Shin Ah Oh, Ho Ra, Donghyun Jee
Purpose Glaucoma affects millions of people globally, and socioeconomic status is known to be associated with glaucoma. This study expands the understanding of the relationship between socioeconomic factors and glaucoma. Methods This study used Korean National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2012, with 24,664 persons who did not have missing records on the key variables. The combined relationship between levels of income and education and the prevalence of glaucoma was examined, as well as the occupational difference in the prevalence of glaucoma...
November 15, 2018: Current Eye Research
Changfan Wu, Xiaotong Han, Xixi Yan, Stuart Keel, Xianwen Shang, Lei Zhang, Mingguang He
OBJECTIVE: To examine the impact of diet on the incidence of cataract surgery among the working-aged diabetic population in Australia. METHODS: This cohort study was conducted among 8,752 participants with diabetes aged 45-65 years who were recruited to the 45 and Up Study from 2006 to 2016. The data was linked to the Medicare Benefits Schedule (MBS) to obtain data on cataract surgery. Diabetes was defined as self-reported on questionnaire or diabetes medication history based on Pharmaceutical Benefits Scheme (PBS)...
November 15, 2018: Current Eye Research
Yinglei Zhang, Yuan Zong, Yongxiang Jiang, Chunhui Jiang, Yi Lu, Xiangjia Zhu
PURPOSE: To investigate the clinical features and efficacy of lens surgery in patients with lens subluxation misdiagnosed as primary angle-closure glaucoma. METHODS: 2054 inpatients with primary angle-closure glaucoma were consecutively recruited. Eighty-five of the patients were rediagnosed as lens subluxation following ultrasound biomicroscopy after hospitalization. Lens surgeries were performed in all patients, and 35 had a follow-up of at least 12 months. Risk factors of postoperative intraocular pressure control were identified with multivariate logistic regression analysis...
November 14, 2018: Current Eye Research
Ouafa Sijilmassi, José Manuel López-Alonso, Aurora Del Río Sevilla, Jorge Murillo González, María Del Carmen Barrio Asensio
PURPOSE: Folic acid (FA) is an essential nutrient for normal embryonic development. FA deficiency (FAD) in maternal diet increases the risk of several defects among the progeny, especially, neural tube defects. The eye begins its development from the neural tube; however, the relationship between FAD and ocular development in the offspring has been little explored and it isn't known how the FAD affects the formation of the eye. Our objective was to analyze the effect of maternal FAD on mouse embryos ocular biometry...
November 7, 2018: Current Eye Research
Yasin Sakir Goker, Cemile Ucgul Atılgan, Kemal Tekin, Hasan Kızıltoprak, Esat Yetkin, Nesibe Karahan Yesil, Mustafa Koc, Pınar Kosekahya
PURPOSE: The aim of this study was to quantitatively compare both the vessel density of macular capillary plexuses and the foveal avascular zone (FAZ) areas of patients receiving hydroxychloroquine (HCQ) therapy for more than 5 years while using age- and sex- matched controls. METHODS: The patients undergoing HCQ who were screened for toxic effects were evaluated. The FAZ parameters included the area, perimeter, and the acircularity index. The foveal density and vessel density values of both the superficial (SCP) and deep capillary plexuses (DCP) were measured using optical coherence tomography angiography (OCTA)...
November 7, 2018: Current Eye Research
Olachi J Mezu-Ndubuisi, Yuyuan Wang, Jamee Schoephoerster, Juliana Falero-Perez, Ismail S Zaitoun, Nader Sheibani, Shaoqin Gong
PURPOSE: Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascularization with reduced levels of vascular endothelial growth factor (VEGF) causing vaso-obliteration (Phase I), followed abnormal neovascularization from increased VEGF (Phase II). We hypothesized that intravitreal pro-angiogenic VEGF-A in microparticle form would promote earlier retinal revascularization in an oxygen-induced ischemic retinopathy (OIR) mouse model. MATERIALS AND METHODS: Wildtype mice (39) were exposed to 77% oxygen from postnatal day 7 (P7) to P12...
November 1, 2018: Current Eye Research
Ahmed E Habib, Ahmed A Abdel-Kader, Iman M Eissa, Ahmed Awadein
PURPOSE: To determine the factors that influence the adherence to follow-up and injections in patients with diabetic macular edema (DME) utilizing a health belief model (HBM) as a theoretical framework, and using demographic variables and knowledge about DME as factors that influence individual perceptions. MATERIAL AND METHODS: A structured questionnaire was developed utilizing the six domains of HBM and using knowledge and other demographics as modifying variables...
November 1, 2018: Current Eye Research
Rose M Olson, Ali Mokhtarzadeh, Linda K McLoon, Andrew R Harrison
PURPOSE: To assess changes in innervation and muscle morphology after repeated botulinum toxin A injections in subjects with benign essential blepharospasm. METHODS: Surgical waste specimens were processed for histologic examination of nerve fibers, neuromuscular junctions, fiber size, and central nucleation and compared to age matched controls and to two subjects with blepharospasm that had not received botulinum toxin A injections Results: There was a significant increase in amount of nerve fibers and numbers of neuromuscular junctions in the orbicularis oculi muscles from subjects with blepharospasm treated repetitively with botulinum toxin A...
October 31, 2018: Current Eye Research
Haifan Huang, Chaoqiang Guan, Danny Shiu-Chun Ng, Xinyu Liu, Haoyu Chen
PURPOSE: 1. To evaluate the repeatability of macular pigment optical density (MPOD) measurements in non-mydriatic and mydriatic conditions with a single wavelength reflection photometry. 2. To compare the non-mydriatic measurement with the mydriatic measurement of MPOD values. METHODS: Fifty-one healthy young subjects were recruited in this prospective study. MPOD parameters including maximum optical intensity (OD), mean OD, volume and area, were measured using a single 460-nm wavelength reflection method (Visucam 200, Carl Zeiss Meditec) twice both before and after pupil dilation...
October 30, 2018: Current Eye Research
Xiaohe Yan, Yun Wang, Lijuan Xu, Yong Liu, Shaojie Song, Kun Ding, Yuan Zhou, Tianzi Jiang, Xiaoming Lin
PURPOSE: The aim of this study was to examine the functional connectivity between the primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging (fMRI). METHODS: A prospective, observational study was conducted. Ten patients with comitant exotropia and eleven matched healthy subjects underwent resting-state fMRI with their eyes closed. Resting-state fMRI was performed using a 3...
October 30, 2018: Current Eye Research
Stefanie R Guenther, Ricarda G Schumann, Felix Hagenau, Armin Wolf, Siegfried G Priglinger, Denise Vogt
PURPOSE: To describe and compare characteristics of premacular membranes in idiopathic macular pucker (iMP) and proliferative vitreoretinopathy (PVR) using immunofluorescence and transmission electron microscopy. MATERIALS AND METHODS: For immunocytochemical and ultrastructural analyses, premacular membranes were harvested during vitrectomy from 16 eyes with iMP and 12 eyes with PVR. All specimens were processed as flat mounts for phase-contrast and fluorescence microscopy...
October 29, 2018: Current Eye Research
Po-Ting Yeh, Yu-Hsun Huang, Shu-Wen Chang, Lu-Chun Wang, Chung-May Yang, Wei-Shiung Yang, Chung-Wu Lin, Chang-Hao Yang
PURPOSE: To investigate the anti-oxidative and anti-inflammatory effects of cilostazol in the ocular tissues of streptozotocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetes was induced in 6-week-old Wistar rats via peritoneal injections of STZ. The treatment group received cilostazol 18 mg/kg/day for 8 weeks (n = 10), and the diabetic group received phosphate buffer solution (n = 20). The expression of oxidative stress and inflammatory mediators in the ocular tissues was then assessed by reverse-transcription polymerase chain reactions, immunohistochemical (IHC) staining, Western blot analysis, and enzyme-linked immunosorbent assay (ELISA)...
October 29, 2018: Current Eye Research
Panpan Li, Jian Wu, Yu Guan, Zhirong Lu, Ying Xue, Min Ji, Huaijin Guan
PURPOSE: To compare the efficiency and safety of one-handed and two-handed coaxial phacoemulsification Material and Methods: Patients with cataracts underwent one-handed (one-handed group) or two-handed coaxial phacoemulsification (two-handed group) with a 2.4-mm clear corneal incision. Intraoperative phaco parameters, total surgical time, postoperative visual acuity, surgically induced astigmatism (SIA), corneal volume (CV), central corneal thickness (CCT) and corneal endothelial cell counts/size were compared between the two groups...
October 29, 2018: Current Eye Research
Mahavir Singh, Akash K George, Rubens Petit Homme, Avisek Majumder, Anwesha Laha, Harpal S Sandhu, Suresh C Tyagi
PURPOSE: To characterize the global profile of circular RNAs (circRNAs) and their differential expression levels in homocysteine (Hcy)-treated ARPE-19 cells, a line of human retinal pigment epithelial cells. MATERIALS AND METHODS: We treated ARPE-19 cells with and without Hcy to investigate the influence of Hcy on circRNA expression levels using dedicated human circRNA microarrays. RESULTS: A total of 12,233 circRNAs were identified out of them 54 were differentially expressed (17 were down-regulated, and 37 were up-regulated) with a fold change > 2...
October 27, 2018: Current Eye Research
Yajie Yu, Yankun Yue, Nianting Tong, Pengfei Zheng, Wu Liu, Ming An
PURPOSE: This study was undertaken to assess the associations between the anatomic outcomes of patients who underwent vitrectomy for rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) and their preoperative variables. METHODS: A total of 175 patients with RRDCD who underwent vitrectomy in one eye were included in the analysis. The primary outcome measured was the retinal status after primary vitrectomy and at the end of follow-up. RESULTS: The retinal reattachment rate was 72...
October 26, 2018: Current Eye Research
Mohammed Iqbal, Ahmed Elmassry, Ahmed Tawfik, Waleed Abou Samra, Mervat Elgharieb, Hosam Elzembely, Ashraf Soliman, Hisham Saad, Islam El Saman, Ahmed Saeed, Mahmoud Farouk, Tarek Tawfik, Amin Abou Ali, Omar Fawzy
PURPOSE: To analyze the visual and refractive outcomes of combined accelerated cross-linking with femtosecond laser intracorneal ring segment implantation for the treatment of pediatric keratoconus. MATERIALS AND METHODS: This retrospective multicenter noncomparative clinical study included 63 eyes of 37 patients (age, 9-17 years) who underwent between August and September 2016 combined cross-linking with intracorneal ring segment implantation for keratoconus. Preoperative and postoperative (6, 12, and 18 months) uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), subjective refractions, keratometry (K), and pachymetry measurements were compared...
October 26, 2018: Current Eye Research
Simona L Schlereth, Marcus Karlstetter, Deniz Hos, Mario Matthaei, Claus Cursiefen, Ludwig M Heindl
PURPOSE: Avascular tissues can be used to identify antilymph- or antihemangiogenic factors. The human sclera -the outer covering layer of the eye, lacks lymphatic vessels and contains only a superficial network of blood vessels and was used here to identify endogenous antiangiogenic factors. METHODS: Expression levels of a panel of 96 known pro- and antiangiogenic factors were analyzed in twelve scleral or conjunctival control samples from normal human donors using real-time PCR...
October 25, 2018: Current Eye Research
Kongnara Papangkorn, Kim R Truett, Albert T Vitale, Chirag Jhaveri, David K Scales, C Stephen Foster, Alyssa Montieth, John W Higuchi, Balbir Brar, William I Higuchi
PURPOSE: Frequent steroid drops represent a challenge in patient compliance. This study evaluated the safety and efficacy of 5 minute topical dexamethasone sodium phosphate-Visulex (DSP-Visulex) treatment regimen (two applications on the first week then weekly after) compared to daily prednisolone acetate 1% (PA) for noninfectious anterior uveitis. MATERIALS AND METHODS: Forty-four patients were randomized to 8% DSP-Visulex with placebo eye drops (8% group, n = 14), 15% DSP-Visulex with placebo eye drops (15% group, n = 15), or Vehicle-Visulex with PA eye drops (PA group, n = 15)...
October 24, 2018: Current Eye Research
Inmaculada Bueno-Gimeno, Noelia Martínez-Albert, Andrés Gené-Sampedro, Enrique España-Gregori
PURPOSE: To assess the relationship between the corneal biomechanical parameters and the anterior segment parameters in Caucasian children. METHODS: This study included 293 eyes from 293 healthy children aged between 6 to 17 years. Corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated with the Ocular Response Analyzer, axial length (AL) with IOLMaster and the anterior segment with Pentacam. Anterior segment parameters obtained were the following: central corneal thickness (CCT), corneal volume (CV), anterior chamber depth (ACD), anterior chamber volume (ACV) and mean anterior and posterior keratometry...
October 22, 2018: Current Eye Research
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