Artyom Kachanov, Anastasiya Kostyusheva, Sergey Brezgin, Ivan Karandashov, Natalia Ponomareva, Andrey Tikhonov, Alexander Lukashev, Vadim Pokrovsky, Andrey A Zamyatnin, Alessandro Parodi, Vladimir Chulanov, Dmitry Kostyushev
Over the past decade, in vivo gene replacement therapy has significantly advanced, resulting in market approval of numerous therapeutics predominantly relying on adeno-associated viral vectors (AAV). While viral vectors have undeniably addressed several critical healthcare challenges, their clinical application has unveiled a range of limitations and safety concerns. This review highlights the emerging challenges in the field of gene therapy. At first, we discuss both the role of biological barriers in viral gene therapy with a focus on AAVs, and review current landscape of in vivo human gene therapy...
March 28, 2024: Medicinal Research Reviews