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Anticancer Research

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https://www.readbyqxmd.com/read/29277831/management-of-lymphomas-a-case-based-approach
#1
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277830/cutaneous-melanoma-1st-edition-a-pocket-guide-for-diagnosis-and-management
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277829/mechanisms-of-molecular-carcinogenesis-volume-2
#3
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277828/book-reviews
#4
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277827/the-efficacy-of-wide-resection-for-musculoskeletal-metastatic-lesions-of-renal-cell-carcinoma
#5
Takashi Higuchi, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kensaku Abe, Yuta Taniguchi, Hisaki Aiba, Hiroyuki Tsuchiya
BACKGROUND/AIM: This study evaluated the outcome of wide resection for metastatic renal cell carcinoma (RCC) to the bone or soft tissue. PATIENTS AND METHODS: Thirty patients who underwent surgery for bone or soft tissue metastatic lesions of RCC were retrospectively evaluated. The surgical procedures were wide resection in 14 patients (group 1) and intralesional resection in 16 (group 2). RESULTS: The 3-, 5-, 10-, and 15-year overall survival (OS) was 76%, 48%, 35%, and 23%, respectively, and OS was significantly favorable in group 1...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277826/prognostic-significance-of-mitochondrial-transcription-factor-a-expression-in-patients-with-right-or-left-sided-colorectal-cancer
#6
Takefumi Katsuki, Yoshifumi Nakayama, Masaki Akiyama, Yusuke Sawatsubashi, Jun Nagata, Noritaka Minagawa, Takayuki Torigoe, Hiroto Izumi, Kimitoshi Kohono, Keiji Hirata
BACKGROUND/AIM: Mitochondrial transcription factor A (mtTFA) is necessary for both the transcription and maintenance of mitochondrial DNA (mtDNA). The present study investigated the clinical significance of mtTFA in patients with right- and left-sided colorectal cancer (CRC). PATIENTS AND METHODS: Surgical specimens from 237 CRC patients were immunohistochemically stained with polyclonal anti-mtTFA antibody. The relationships among the mtTFA expression, clinicopathological factors and prognosis were evaluated...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277825/stereotactic-radiosurgery-alone-for-one-to-two-brain-metastases-from-cancer-of-unknown-primary
#7
Liesa Dziggel, Amira Bajrovic, Steven E Schild, Dirk Rades
BACKGROUND/AIM: The use of stereotactic radiosurgery (SRS) alone has become popular for treating patients with a limited number of brain metastases. In very few patients, the primary tumor leading to cerebral spread is unknown. This study investigated the role of SRS for this rare situation. PATIENTS AND METHODS: Eight patients with 1-2 brain metastases from cancer of unknown primary (CUP) received SRS alone (median dose 20 Gy). Five clinical factors were evaluated for association with local control of the irradiated lesions, freedom from new cerebral lesions and survival...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277824/carcinoembryonic-antigen-as-a-predictive-biomarker-of-response-to-nivolumab-in-non-small-cell-lung-cancer
#8
Yuki Kataoka, Katsuya Hirano, Tomoko Narabayashi, Satoshi Hara, Daichi Fujimoto, Tae Tanaka, Noriyuki Ebi, Keisuke Tomii, Hiroshige Yoshioka
AIM: To find new predictive factors for the efficient use of immune checkpoint inhibitors in patients with non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: In this multicenter retrospective cohort study, we evaluated consecutive patients treated with nivolumab between January and October 2016 after second-line systemic chemotherapy. The endpoint was progression-free survival (PFS), as defined by Response Evaluation Criteria in Solid Tumors version 1.1. RESULTS: A total of 189 patients were included in the study...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277823/clinical-significance-of-pd-l1-expression-in-brain-metastases-from-non-small-cell-lung-cancer
#9
Shinkichi Takamori, Gouji Toyokawa, Isamu Okamoto, Kazuki Takada, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Nobutaka Mukae, Fumihiko Hirai, Tetsuzo Tagawa, Yoshinao Oda, Toru Iwaki, Koji Iihara, Yoichi Nakanishi, Yoshihiko Maehara
AIM: To investigate the association between positivity for programmed cell death-ligand 1 (PD-L1) in brain metastases (BM) and the prognosis or clinical factors in patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Thirty-two patients with surgically resected brain-metastatic NSCLC were enrolled. The PD-L1 expression in BM was analyzed using the antibody against human PD-L1 (clone SP142). The PD-L1 positivity was defined as PD-L1 expression on brain-metastatic tumor cells of ≥5%...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277822/bevacizumab-added-to-moderate-dose-chemotherapy-for-refractory-uterine-cancer
#10
Howard W Bruckner, Daniel Gurell, Azriel Hirschfeld
BACKGROUND/AIM: Bevacizumab (bev), when added to a moderate dose combination of previously failed cytotoxins, as a third- and fourth-line therapy for refractory gastric, cholangiocarcinoma, and ovarian cancers, produced high-quality responses. The regimen was based on preclinical models designed in order to simultaneously partner both bev and each of the cytotoxins with 4-5 synergistic drugs. PATIENTS AND METHODS: Eligible patients (n=9) had high-grade endometrial tumors and had failed standard chemotherapy...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277821/iodine-content-analysis-using-dual-energy-computed-tomography-as-a-biomarker-of-transitional-cell-carcinoma-an-experience-with-separation-of-the-clotted-blood-and-tumorous-tissue
#11
Hynek Mirka, Jan Baxa, Milan Hora, Ondrej Hes, Ondrej Topolcan, Jiri Ferda
BACKGROUND/AIM: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT). MATERIALS AND METHODS: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). DECT was performed in all patients after intravenous administration of the iodinated contrast material...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277820/the-severity-of-anastomotic-leakage-may-negatively-impact-the-long-term-prognosis-of-colorectal-cancer
#12
Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Hirofumi Yamamoto, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
BACKGROUND: Anastomotic leakage is a major critical complication in colorectal resection. Although its relevance to oncological outcome has been widely investigated, the correlation between the severity of anastomotic leakage and oncological outcome is not well understood. PATIENTS AND METHODS: The clinical characteristics of 615 patients who underwent curative resection of colorectal cancer with anastomosis and normal healing were compared with 44 similar patients who experienced anastomotic leakage...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277819/hepatic-resection-followed-by-hepatic-arterial-infusion-chemotherapy-for-hepatocellular-carcinoma-with-intrahepatic-dissemination
#13
Kunitaka Kuramoto, Toru Beppu, Hidetoshi Nitta, Katsunori Imai, Toshiro Masuda, Tatsunori Miyata, Yuki Koga, Yuki Kitano, Takayoshi Kaida, Shigeki Nakagawa, Hirohisa Okabe, Hiromitsu Hayashi, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Ken Kikuchi, Hideo Baba
BACKGROUND/AIM: To investigate the utility of adjuvant hepatic arterial infusion chemotherapy (HAIC) following hepatectomy for patients with hepatocellular carcinoma (HCC) with intrahepatic dissemination (IHD) after local ablation therapy. PATIENTS AND METHODS: Twelve patients with HCC with IHD were divided into two groups: HAIC group (n=6) underwent hepatectomy followed by HAIC; and the non-HAIC group (n=6) underwent hepatectomy alone. HAIC with cisplatin and 5-fluorouracil was started within a month and was continued for a month: Results: At the first local ablation, tumors close to the major portal vein and insufficient ablation were recognized in eight (67...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277818/re-irradiation-with-36-gy-1-5-gy-twice-daily-plus-paclitaxel-for-advanced-recurrent-and-previously-irradiated-scchn-is-feasible
#14
Dirk Rades, Tobias Bartscht, Christian Idel, Samer G Hakim
BACKGROUND/AIM: Many patients developing a loco-regional recurrence of squamous cell carcinoma of head and neck (SCCHN) have a poor prognosis. Often, recurrences are unresectable, and patients require a second course of radiotherapy or chemoradiation. We present an approach of chemoradiation including mainly 30 Gy of radiotherapy (1.5 Gy twice daily) plus concurrent paclitaxel. To further improve the prognoses of these patients, we increased the radiation dose from 30 to 36 Gy. PATIENTS AND METHODS: In four patients with recurrent and previously irradiated SCCHN (60-70 Gy) chemoradiation was carried out using 36 Gy (1...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277817/evaluation-of-a-transumbilical-incision-as-an-approach-for-organ-removal-in-laparoscopy-assisted-colectomy
#15
Kodai Tomioka, Masahiko Murakami, Makoto Watanabe, Akira Fujimori, Tomotake Koizumi, Satoru Goto, Koji Otsuka, Takeshi Aoki
AIM: To investigate the risk factors of transumbilical incision for organ removal in laparoscopy-assisted colectomy (LAC). PATIENTS AND METHODS: We enrolled 348 consecutive patients who underwent LAC at our hospital between 2010 and 2013. The occurrence of superficial surgical site infection (SSI) and hernia at the transumbilical port site were recorded. RESULTS: SSI was observed in 15 patients (4.31%); there were no obvious associated risk factors...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277816/paraneoplastic-auto-immune-hemolytic-anemia-an-unusual-sequela-of-enteric-duplication-cyst
#16
Arsha Sreedhar, Ranjit Nair, William Scialla
Enteric duplication (ED) cysts are rare congenital anomalies of the alimentary canal that present in childhood. Although benign in most case, ED cysts have the potential to cause complications including a rare association with secondary carcinomas. Autoimmune hemolytic anemia presenting as a paraneoplastic syndrome secondary to solid tumors is an unusual phenomenon. Here we report a patient case with ED cyst described in association with intestinal adenocarcinoma and warm-auto immune hemolytic anemia, with resolution of the hemolysis upon its surgical resection...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277815/the-outcome-of-sorafenib-therapy-on-unresectable-hepatocellular-carcinoma-experience-of-conversion-and-salvage-hepatectomy
#17
Toshiaki Yoshimoto, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Yusuke Arakawa, Shuichi Iwahashi, Y U Saito, Chie Takasu, Daichi Ishikawa, Hiroki Teraoku, Yoshimi Bando, Mitsuo Shimada
BACKGROUND/AIM: We report the outcomes of sorafenib therapy for advanced hepatocellular carcinoma (HCC) in our Department. PATIENTS AND METHODS: Thirty-eight patients with unresectable HCC who were administrated sorafenib from 2009 to 2015 were investigated retrospectively. RESULTS: The 1-year overall survival rate was 59.3%. The macroscopic vascular invasion and response rate were independent prognostic factors of survival. Surgical resection after sorafenib achieved long-term survival in two cases...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277814/low-visceral-fat-content-is-a-negative-predictive-marker-for-bevacizumab-in-metastatic-colorectal-cancer
#18
Yuji Miyamoto, Eiji Oki, Yasunori Emi, Shoji Tokunaga, Mototsugu Shimokawa, Yutaka Ogata, Yoshito Akagi, Yasuo Sakamoto, Takaho Tanaka, Hiroshi Saeki, Yoshihiko Maehara, Hideo Baba
AIM: This study aimed to clarify the predictive impact of visceral fat on response to bevacizumab in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: Pretreatment computed tomography was used to measure visceral fat area (VFA) and patients with mCRC receiving first-line chemotherapy with/without bevacizumab were divided by median VFA value into two groups: high VFA and low VFA. RESULTS: In the bevacizumab-treated group, patients with low VFA had significantly shorter overall survival (OS) than patients with high VFA in univariate (median=21...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277813/clinical-trial-of-radiotherapy-after-intravenous-injection-of-acridine-orange-for-patients-with-cancer
#19
Katsuyuki Kusuzaki, Tetsuo Takai, Hitoshi Yoshimura, Kazuya Inoue, Shigeo Takai, Nicola Baldini
AIM: We previously found that low-dose X-ray treatment after systemic administration of acridine orange (AO), which is known to have a low toxicity in animals, inhibited tumor growth in experimental studies using mouse osteosarcoma. In this pilot study, we planned to verify the toxicity of intravenous injection of low-dose AO in humans and investigate the anticancer effect of radiation after systemic AO administration (iAOR) for human cancer. PATIENTS AND METHODS: Eight patients with terminal cancer were treated with iAOR...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277812/association-between-laryngopharyngeal-reflux-and-radiation-induced-mucositis-in-head-and-neck-cancer
#20
Kohtaro Eguchi, Masami Suzuki, Shota Ida, Keita Mori, Hisao Imai, Shigehiro Kudo, Ken Ando, Keiko Higuchi, Takeshi Ebara
BACKGROUND/AIM: We investigated whether laryngopharyngeal reflux (LPR) is a risk factor for radiation-induced mucositis. PATIENTS AND METHODS: This was a retrospective cohort study using our departmental database. The study included patients with stage I or II laryngeal and hypopharyngeal cancers treated with radiation therapy alone between April 2009 and March 2014. Based on endoscopic findings, baseline laryngeal signs were evaluated using the reflux finding score (RFS), and the severity of mucositis was assessed during and after radiation therapy...
January 2018: Anticancer Research
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