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Anticancer Research

Anastasios Angelou, Efstathios Antoniou, Nikolaos Garmpis, Christos Damaskos, Stamatios Theocharis, Georgios-Antonios Margonis
BACKGROUND: The role of CD40/CD40L in carcinogenesis is widely examined. The mechanisms linking the CD40/CD40L system and the soluble form of CD40 ligand (sCD40L) with neoplasia are nowadays a topic of intensive research. CD40L and sCD40L belong to the TNF superfamily and are molecules with a proinflammatory role. A variety of cells express CD40L such as the immune system cells, the endothelial cells and activated platelets. Although many medications such as statins have been shown to reduce sCD40L, it is still debated whether specific treatments targeting the CD40/CD40L system will prove to be effective against carcinogenesis in the near future...
May 2018: Anticancer Research
Shuichi Shinohara, Masakazu Sugaya, Takamitsu Onitsuka, Kazuhiko Machida, Masaki Matsuo, Fumihiro Tanaka
BACKGROUND/AIM: C-reactive protein (CRP) is associated with cancer progression; however, the prognostic impact of postoperative CRP remains controversial. The aim of this study was to investigate the prognostic significance of postoperative CRP in patients with resected non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: A total of 198 consecutive patients with NSCLC that had undergone lobectomy were retrospectively reviewed. CRP was measured on postoperative days 1, 3, and 5...
May 2018: Anticancer Research
Tzu-Yao Liao, Chuang-Chi Liaw, Ke-Hung Tsui, Yu-Hsiang Juan
BACKGROUND/AIM: Renal pelvis cancer with invasion of the renal vein or inferior vena cava (IVC) carries a poor prognosis. The present study investigated whether early-onset lung metastasis in these patients contributes to their poor outcome. PATIENTS AND METHODS: Data were retrospectively collected from hospitalized patients with metastatic renal pelvis urothelial cancer. The parameters used to estimate the risk of lung metastasis were based on computed tomographic (CT) scans...
May 2018: Anticancer Research
Nikolaos Machairas, Dimitrios Papaconstantinou, Paraskevas Stamopoulos, Anastasia Prodromidou, Zoe Garoufalia, Eleftherios Spartalis, Ioannis D Kostakis, Georgios C Sotiropoulos
BACKGROUND/AIM: Tumor recurrence complicates more than half of patients at 5 years after primary hepatocellular carcinoma (HCC) resection. Repeat open liver resection (ROLR) is the standard procedure for patients eligible for repeat resection, whereas laparoscopic repeat liver resection (RLLR) has been proposed as an alternative approach. The aim of this systematic review is to evaluate studies reporting on outcomes of RLLR for recurrent HCC (rHCC). MATERIALS AND METHODS: A comprehensive search of the literature was undertaken...
May 2018: Anticancer Research
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND/AIM: Performing hysterectomy following chemoradiotherapy (CRT) for IB2/IIA2 cervical cancer is highly controversial. This study evaluated national practice patterns in utilization of post-CRT hysterectomy in the United States compared to CRT alone, as well as outcomes. MATERIALS AND METHODS: The National Cancer Database was queried for patients with newly diagnosed IB2/IIA2 cervical cancer. Multivariable logistic regression analysis assessing factors predictive of undergoing post-CRT hysterectomy...
May 2018: Anticancer Research
Seo Hee Choi, Jee Suk Chang, Jinhyun Choi, So Hyun Park, Ki Chang Keum, Kyung Ran Park, Chang Geol Lee
BACKGROUND/AIM: Information on re-irradiation (re-RT) for recurrent and second primary head and neck cancer is limited. Herein, a description of our long-term experience of re-RT for previously irradiated head and neck cancer is provided. MATERIALS AND METHODS: A retrospective review was performed for 73 consecutive patients re-irradiated for head and neck cancer between 2006 and 2015. Re-RT targets encompassed only the recurrent gross tumor and had tight margins (5-10 mm)...
May 2018: Anticancer Research
Marko Lucijanic, David Cicic, Tajana Stoos-Veic, Vlatko Pejsa, Jelena Lucijanic, Amina Fazlic Dzankic, Josipa Vlasac Glasnovic, Ena Soric, Marko Skelin, Rajko Kusec
BACKGROUND/AIM: We aimed to investigate clinical associations of inflammatory biomarkers neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) in patients with myelofibrosis, myeloproliferative neoplasm with inflammatory background. PATIENTS AND METHODS: We retrospectively analyzed a cohort of 102 myelofibrosis patients. NLR and PLR were assessed in addition to other disease-specific parameters. RESULTS: NLR and PLR were significantly higher in myelofibrosis than in healthy controls...
May 2018: Anticancer Research
Gi Yong Hwang, Dong Won Baek, Hee Jeong Cho, Soo Jung Lee, Yee Soo Chae, Byung Woog Kang, In Hee Lee, Jong Gwang Kim, An Na Seo, Han Ik Bae, Ki Bum Park, Ji Yeon Park, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung
BACKGROUND/AIM: This study investigated the clinical prognostic relevance of the neutrophil-to-lymphocyte ratio (NLR) in patients with human epidermal receptor 2 (HER2)-positive metastatic advanced gastric cancer (AGC) treated with combination chemotherapy including trastuzumab. PATIENTS AND METHODS: This is a retrospective analysis of 73 patients diagnosed with metastatic AGC who were treated with trastuzumab combination chemotherapy. NLR was calculated as the neutrophil count divided by the lymphocyte count...
May 2018: Anticancer Research
Takayuki Kaburagi, Moriyuki Kiyoshima, Takeshi Nawa, Hideo Ichimura, Takefumi Saito, Kenji Hayashihara, Hideyasu Yamada, Hiroaki Satoh, Takeo Endo, Yoshihisa Inage, Kazuhito Saito, Masaharu Inagaki, Nobuyuki Hizawa, Yukio Sato, Hiroichi Ishikawa, Mitsuaki Sakai, Koichi Kamiyama, Norihiro Kikuchi, Hiroyuki Nakamura, Kinya Furukawa, Takahide Kodama, Takaaki Yamashita, Akihiro Nomura, Susumu Yoshida
AIM: To describe the prevalence and determinants of acquired epidermal growth factor receptor (EGFR) T790M gene mutation in a clinical practice setting. MATERIALS AND METHODS: We performed a retrospective chart review study between January 2013 and November 2017 across multiple institutes, covering a population of 3 million people. RESULTS: We reviewed the charts of 233 patients non-small cell lung cancer with EGFR mutations. Of them, 99 (42...
May 2018: Anticancer Research
Giulia Marvaso, Anna Viola, Cristiana Fodor, Barbara A Jereczek-Fossa
BACKGROUND/AIM: Patients with locally advanced prostate cancer are generally treated with radiotherapy (RT) which can be combined with hormonal therapy. RT plus monotherapy with luteinizing hormone-releasing hormone (LHRH) analog triptorelin was compared to RT plus total androgen block (TAB). PATIENTS AND METHODS: A retrospective study was carried out on patients with locally advanced prostate cancer comparing RT plus monotherapy versus RT plus TAB. RESULTS: For overall survival, no differences between patients receiving RT with monotherapy and those treated with TAB were observed...
May 2018: Anticancer Research
Jun Kiuchi, Shuhei Komatsu, Toshiyuki Kosuga, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Daisuke Ichikawa, Eigo Otsuji
AIM: This study was designed to investigate the clinical impact of postoperative serum albumin level on severe postoperative complications (SPCs) and prognosis. MATERIALS AND METHODS: Data for a total of 728 consecutive patients who underwent curative gastrectomy for gastric cancer between 2004 and 2013 were retrospectively analyzed. From these patients, a propensity score-matched analysis was performed based on 14 clinicopathological and surgical factors. RESULTS: Short-term decrease in postoperative serum albumin level was not associated with the occurrence of SPCs...
May 2018: Anticancer Research
Yohei Kawaguchi, Tetsuya Okano, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
BACKGROUND/AIM: The transition rate from first-line epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) to cytotoxic chemotherapy (Ct) is poor. The prognosis according to treatment sequence and the reasons patients could not shift from first-line EGFR-TKIs to Ct were herein analyzed. PATIENTS AND METHODS: Overall, 159 epidermal growth factor receptor mutation-positive adenocarcinoma patients were enrolled in this study. RESULTS: The median survival times of EGFR-TKIs combined with Ct and EGFR-TKIs were 59...
May 2018: Anticancer Research
Victor Hugo Pereira DA Silva, Mariana Carvalho Andrade, Samuel Rangel Claudio, Veronica Quispe Yujra, Maria Esther Suarez Alpire, Jean Nunes Dos Santos, Patricia Ramos Cury, Daniel Araki Ribeiro
BACKGROUND/AIM: Since street sweepers comprises a group of workers who are in daily contact with rubbish, dust and air pollution, the aim of this study was to evaluate potential cytotoxic and mutagenic effects in buccal mucosa cells of street sweepers. MATERIALS AND METHODS: A total of 20 male street sweepers aged from 22 to 56 years were included in the experimental group. A total of 20 men matched by age were used as the control group. Cytotoxicity and mutagenicity were analyzed by micronucleus test in buccal mucosal cells...
May 2018: Anticancer Research
Francesco Pasqualetti, Marco Panichi, Aldo Sainato, Davide Baldaccini, Paola Cocuzza, Alessandra Gonnelli, Sabrina Montrone, Alessandro Molinari, Sara Barbiero, Andrea Bruschi, Elisa Notini, Stefano Ursino, Valentina Mazzotti, Riccardo Morganti, Gabriele Coraggio, Martina Cantarella, Paola Anna Erba, Fabiola Paiar
BACKGROUND/AIM: In the last years, the use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. In this study, we aimed to assess the role of IG-SBRT in terms of local control and safety in patients with metastatic prostate cancer. MATERIALS AND METHODS: Primary and secondary endpoints of this prospective observational study were local control and safety related to IG-SBRT. All lesions were treated with 24 Gy as a single fraction or 27 Gy in 3 fractions...
May 2018: Anticancer Research
Kensuke Tanaka, Gouji Toyokawa, Tetsuzo Tagawa, Kayo Ijichi, Naoki Haratake, Fumihiko Hirai, Yoshinao Oda, Yoshihiko Maehara
Growing teratoma syndrome (GTS) of the lung is extremely rare, and there are very few reports on this condition. This is a case report of GTS of the lung that was successfully treated by resection. A 19-year-old man, who had been diagnosed with a testicular tumor, lung metastases and left hilar lymph node metastasis, underwent surgical resection for left testicular cancer. After orchiectomy and chemotherapy, the patient was successfully treated with wedge resection of the right upper lobe and left upper lobectomy...
May 2018: Anticancer Research
Dirk Rades, Liesa Dziggel, Oliver Blanck, Niklas Gebauer, Tobias Bartscht, Steven E Schild
AIM: To design a tool to predict the probability of new cerebral lesions after stereotactic radiosurgery/radiotherapy for patients with 1-3 brain metastases from colorectal cancer. PATIENTS AND METHODS: In 21 patients, nine factors were evaluated for freedom from new brain metastases, namely age, gender, Karnofsky performance score (KPS), tumor type, number, maximum total diameter of all lesions and sites of cerebral lesions, extra-cranial metastases, and time from cancer diagnosis to irradiation...
May 2018: Anticancer Research
Roberto Iacovelli, Michele DE Tursi, Claudia Mosillo, Antonio Ciardi, Consiglia Carella, Clara Natoli, Giuseppe Naso, Enrico Cortesi
BACKGROUND/AIM: The expression of IL-8 and FGFR has been related to prognosis and pathological features in renal cell carcinoma. We investigated the relationship between IL-8 and FGFR and the outcome in metastatic renal cell carcinoma (mRCC) patients. MATERIALS AND METHODS: Clinical data and histological samples of patients affected by mRCC and treated with targeted agents were reviewed. The expression of proteins was assessed using immunohistochemistry. RESULTS: FGFR1, FGFR2, and IL-8 were found to be expressed in 16%, 30%, and 50% of cases, respectively...
May 2018: Anticancer Research
Takuya Owari, Makito Miyake, Yasushi Nakai, Yosuke Morizawa, Shunta Hori, Satoshi Anai, Nobumichi Tanaka, Kiyohide Fujimoto
AIM: The aim of this study was to develop a risk scoring system specific to patients with bone metastasis of genitourinary cancer. MATERIALS AND METHODS: This study included 180 patients with bone metastasis of three major types of genitourinary cancer: prostate cancer (n=111), renal cell carcinoma (n=43,), and urothelial carcinoma (n=26). Clinical factors at diagnosis of bone metastasis were evaluated to identify independent prognostic factors. RESULTS: Multivariate analysis showed that type of primary cancer, poor performance status, the presence of visceral metastases, high Glasgow prognostic score and elevated neutrophil-to-lymphocyte ratio were independently predictive of poor prognosis...
May 2018: Anticancer Research
Morikatsu Yoshida, Toru Beppu, Shinya Shiraishi, Noriko Tsuda, Fumi Sakamoto, Kunitaka Kuramoto, Hirohisa Okabe, Hidetoshi Nitta, Katsunori Imai, Seiji Tomiguchi, Hideo Baba, Yasuyuki Yamashita
Background/Aim: The sacrifice of a major hepatic vein can cause hepatic venous congestion (HVC). We evaluated the effects of HVC on regional liver function using the liver uptake value (LUV), that was calculated from 99m Tc-labeled-galactosyl-human-serum-albumin ( 99m Tc-GSA) single-photon emission computed tomography (SPECT) /contrast-enhanced computed tomography (CE-CT) fused images. Patients and Methods: Sixty-two patients underwent 99m Tc-GSA SPECT/CE-CT prior to hepatectomy for liver cancer and at 7 days after surgery were divided into groups with (n=8) and without HVC (n=54)...
May 2018: Anticancer Research
Jun Iwabu, Tsutomu Namikawa, Sachi Tsuda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
Extended lymph node dissection in patients with gastric cancer with liver cirrhosis can lead to severe morbidity and mortality, especially in those with Child-Pugh class B or C cirrhosis. We, herein, report a case of advanced gastric cancer with alcoholic liver cirrhosis that was successfully treated by surgery. A 58-year-old male patient was diagnosed with gastric cancer with alcoholic liver cirrhosis Child-Pugh class B. A red blood cell transfusion was performed to treat cancer-related hemorrhage; however, the patient's hemoglobin level did not improve and distal gastrectomy with D1 lymph node dissection was subsequently performed to prevent further bleeding...
May 2018: Anticancer Research
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