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Anticancer Research

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May 2017: Anticancer Research
Matteo Barabino, Andrea Gatti, Roberto Santambrogio, Micol Polizzi, Carmelo Luigiano, Enrico Opocher
AIM: To investigate the role of intraoperative local ablation techniques (LATs) in bilobar colorectal liver metastases (bCRLM). PATIENTS AND METHODS: Among patients who underwent LAT for CRLM between 2005 and 2015, we selected 33 patients with bilobar disease submitted to thermal ablation alone or associated to liver resection. Primary end-point was complete local response at one month (CLR). Secondary end-points were morbidity, mortality, disease-free survival (DFS), local tumor recurrence (LTR) and long-term survival...
May 2017: Anticancer Research
Takaki Akamine, Gouji Toyokawa, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Masakazu Katsura, Kazuki Takada, Fumihiro Shoji, Tatsuro Okamoto, Yoshihiko Maehara
BACKGROUND: The usefulness of the controlling nutritional status (CONUT) score for preoperative nutritional assessment has been reported in resected colorectal and esophageal cancer, but not in lung cancer with obstructive lung disease. PATIENTS AND METHODS: We retrospectively reviewed 109 patients with adenocarcinoma with obstructive pulmonary disease. We set 1 as the cut-off value for the CONUT score and classified patients into high (≥1) and low (0) CONUT groups...
May 2017: Anticancer Research
Branislav Bystricky, Zuzana Cierna, Gabriela Sieberova, Pavol Janega, Marian Karaba, Gabriel Minarik, Juraj Benca, Tatiana Sedlackova, Silvia Jurisova, Paulina Gronesova, Daniel Pindak, Jan Macuch, Jozef Mardiak, Michal Mego
BACKGROUND/AIM: Annexin A2 (ANXA2) is a phospholipid-binding protein involved in fibrinolysis, cell proliferation, migration and metastatic dissemination. Circulating tumor cells (CTCs) are cells responsible for tumor dissemination and have a prognostic value in several types of cancers including breast cancer. Previously, we found correlation between CTCs and activation of coagulation. This study aimed to correlate CTCs with ANXA2 expression on CTCs, tumor cells and tumor associated stroma in primary breast cancer (PBC) patients...
May 2017: Anticancer Research
Hironori Yoshida, Young Hak Kim, Hiroaki Ozasa, Hiroki Nagai, Yuichi Sakamori, Takahiro Tsuji, Takashi Nomizo, Tomoko Funazo, Yuto Yasuda, Toyohiro Hirai
AIM: To evaluate the utility of plasma circulating tumor DNA (ctDNA) using the peptide nucleic acid-locked nucleic acid (PNA-LNA) clamp method to detect epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) patients who had progressed under treatment with EGFR-tyrosine kinase inhibitors (TKIs). PATIENTS AND METHODS: Blood samples were collected from patients with EGFR mutation-positive NSCLC who had progressed on EGFR-TKIs between March 2016 and August 2016 at the Kyoto University Hospital...
May 2017: Anticancer Research
Yoshikazu Kanazawa, Itsuo Fujita, Diasuke Kakinuma, Hiroki Arai, Kunihiko Matsuno, Tomohiro Shimoda, Kazuhide Ko, Shunji Kato, Eiji Uchida
BACKGROUND: Taxane-based chemotherapy is useful for peritoneal dissemination control in advanced/recurrent gastric cancer; however, insufficient relative dose intensity (RDI) may preclude disease control achievement. Nab-paclitaxel, with high tumour permeability, is a promising second- or later-line treatment. PATIENTS AND METHODS: We retrospectively evaluated the clinical safety and efficacy of nab-paclitaxel for advanced/recurrent gastric cancer patients treated between April 2013 and December 2015...
May 2017: Anticancer Research
Keiichi Jingu, Yukinori Matsuo, Hiroshi Onishi, Takaya Yamamoto, Masahiko Aoki, Yuji Murakami, Hideomi Yamashita, Hisao Kakuhara, Kenji Nemoto, Toru Sakayauchi, Masahiko Okamoto, Yuzuru Niibe, Yasushi Nagata, Kazuhiko Ogawa
AIM: To evaluate the efficacy of stereotactic body radiotherapy (SBRT) for pulmonary metastasis from colorectal cancer. PATIENTS AND METHODS: Data for 104 lesions from 93 patients who underwent SBRT for pulmonary oligometastases from colorectal cancer at ten Institutions were retrospectively analyzed. Toxicity was graded according to the Common Terminology Criteria for Adverse Events v4.0. RESULTS: The median calculated biological effective dose using the linear-quadratic model with α/β of 10 Gy (BED10) was 105...
May 2017: Anticancer Research
Dirk Rades, Annett Maderer, Annika Panzner, Peter Hunold, Visvakanth Sivanathan, Heinz Schmidberger, Markus H Moehler
BACKGROUND/AIM: Prognoses of patients receiving radio-chemotherapy with 5-fluorouracil (5-FU) and cisplatin for unresectable esophageal cancer may be improved with the addition of cetuximab. This phase I study aimed to define the maximum tolerated dose of 5-FU when combined with cisplatin, cetuximab and radiotherapy. PATIENTS AND METHODS: Treatment included 59.4 Gy of radiotherapy concurrently with two courses of cisplatin (20 mg/m(2), d1-4) and 5-FU (dose level 0: 500 mg/m(2), dose level 1: 750 mg/m(2), d1-4; dose level 2: 1,000 mg/m(2), d1-4), followed by two courses of chemotherapy...
May 2017: Anticancer Research
Jiri Presl, Petra Ovesna, Zdenek Novotny, Pavel Vlasak, Jiri Bouda, Jan Kostun, Ondrej Topolcan, Radek Kucera, Marketa Bednarikova, Vit Weinberger
AIM: To analyze the utility of HE4 assessment in preoperative management of patients with early-stage endometrial cancer for stratification into low-risk and high-risk groups. PATIENTS AND METHODS: The following data were prospectively collected from patients operated for endometrial cancer from 05/2012 till 9/2016; age, HE4, CA125, expert ultrasound examination of the pelvis, histotype, grade, FIGO stage. RESULTS: In total, 124 patients were enrolled...
May 2017: Anticancer Research
Lisa Manig, Lukas Käsmann, Stefan Janssen, Steven E Schild, Dirk Rades
BACKGROUND/AIM: This study investigated three comorbidity scales and the Eastern Cooperative Oncology Group performance score (ECOG-PS) for survival in patients receiving local irradiation for bladder cancer. PATIENTS AND METHODS: Sixty-four patients receiving organ-preserving radio-chemotherapy or radiotherapy for urinary bladder cancer were retrospectively evaluated. Charlson Comorbidity Index (CCI), Simplified Comorbidity Score (SCS), Age-Adjusted Charlson Comorbidity Index (AAC) and ECOG-PS were analyzed for associations with survival...
May 2017: Anticancer Research
Wolfgang Eisterer, Gudrun Piringer, Alexander DE Vries, Dietmar Öfner, Richard Greil, Jörg Tschmelitsch, Hellmut Samonigg, Lidija Sölkner, Michael Gnant, Josef Thaler
AIM: To evaluate feasibility and safety of neoadjuvant chemotherapy with capecitabine, oxaliplatin and bevacizumab followed by concomitant standard chemoradiation and surgical resection in patients with high-risk locally advanced rectal cancer. PATIENTS AND METHODS: Magnetic resonance imaging (MRI)-defined high-risk cT3/4 rectal cancer patients were treated with 3 cycles of neoadjuvant chemotherapy with capecitabine (1,000 mg/m(2) twice daily days 1-14, 22-35, 43-56), oxaliplatin (130 mg/sqm on days 1, 22, 43) and bevacizumab (7...
May 2017: Anticancer Research
Woong Bae Ji, Jun Won Um, Je Seock Ryu, Kwang Dae Hong, Jung Sik Kim, Byung Wook Min, Sung Yeop Joung, Ju Han Lee, Young Sik Kim
AIM: To evaluate whether the results of chemosensitivity testing were associated with prognosis of colorectal cancer patients after adjuvant 5-fluorouracil (FU)/ leucovorin chemotherapy. PATIENTS AND METHODS: Eighty-nine patients who received 5-FU/leucovorin adjuvant chemotherapy for colorectal cancer were enrolled. Chemosensitivity tests were performed and tumor growth inhibition rate was calculated using the MTT (3-(4,5-dimethylthiazol-2-yl)02,5-diphenyl-2H tetrazolium bromide) assay...
May 2017: Anticancer Research
Tatsunori Miyata, Yo-Ichi Yamashita, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
BACKGROUND/AIM: The prognostic effect of lymph node dissection (LND) in intrahepatic cholangiocarcinoma (ICC) remains unclear. The aim of this study was to reveal the clinical benefits of LND in patients with ICC after curative hepatic resections. PATIENTS AND METHODS: We retrospectively analyzed 64 patients with ICC who underwent primary curative resections between June 2002 and February 2016 and evaluated the survival benefits of LND. RESULTS: We performed LND on patients suspected to have LN metastasis before operation (23/64 cases; 35...
May 2017: Anticancer Research
Kyoko Inadomi, Hitoshi Kusaba, Yuzo Matsushita, Risa Tanaka, Kenji Mitsugi, Kohei Arimizu, Gen Hirano, Akitaka Makiyama, Hirofumi Ohmura, Keita Uchino, Fumiyasu Hanamura, Yoshihiro Shibata, Miyuki Kuwayama, Taito Esaki, Kotoe Takayoshi, Shuji Arita, Hiroshi Ariyama, Koichi Akashi, Eishi Baba
BACKGROUND: Significant efficacy of oxaliplatin-based chemotherapy has been demonstrated for advanced gastric cancer (AGC). However, the appropriate dose of oxaliplatin, and the efficacy and toxicity of administration of oxaliplatin subsequent to cisplatin therapy still remain unclear. PATIENTS AND METHODS: In total, 55 patients with AGC that were scheduled to receive oxaliplatin-based chemotherapy were prospectively examined. RESULTS: The median age was 67 years and oxaliplatin was administered to 39 (71%) patients as first-line and in 16 (29%) patients as second-line therapy...
May 2017: Anticancer Research
Masahide Yamamoto, Ken Watanabe, Tetsuya Fukuda, Osamu Miura
Prognostic models for primary diffuse large B-cell lymphoma (DLBCL) resistant to or relapsing after initial therapy with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) have not been well-established. A refined categorization of normalized lactate dehydrogenase (LDH) (the ratio to the upper limit of normal) was recently shown to predict prognosis of newly-diagnosed patients with DLBCL better than mere dichotomization of LDH into 'normal' and 'abnormal' groups. To define the prognostic impact of the LDH ratio and various other factors in order to develop a new prognostic model system, we retrospectively analyzed 31 patients with refractory/relapsed DLBCL initially treated with R-CHOP at our hospital from 2002 to 2013...
May 2017: Anticancer Research
David O Irabor, Olayiwola A Oluwasola, Olufemi J Ogunbiyi, Olabiyi G Ogun, Clement A Okolo, Marilena Melas, Stephen B Gruber, Chanjuan Shi, Leon Raskin
BACKGROUND: Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS: We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archival samples from the University of Ibadan, Nigeria. RESULTS: Nigerian cases of CRC were MSI-high in 43% and MSI-high CRC had significantly lower histological heterogeneity than microsatellite-stable CRC (20% vs...
May 2017: Anticancer Research
Matti Eskelinen, Tuomas Selander, Paula Ollonen, Riika Korhonen
AIM: The Montgomery-Asberg Depression Rating Scale (MADRS) is one of the most widely used examiner rating instruments for screening, diagnosis and measuring the severity of depression. However, the long-term predictive value of the MADRS in patients admitted to the breast cancer diagnosis unit (BCDU) is unknown. PATIENTS AND METHODS: In the Kuopio Breast Cancer Study women with breast symptoms were evaluated for the total MADRS score before any diagnostic procedures...
May 2017: Anticancer Research
Silvia Angelini, Andrea Botticelli, Concetta Elisa Onesti, Raffaele Giusti, Valentina Sini, Valeria Durante, Lidia Strigari, Giovanna Gentile, Bruna Cerbelli, Patrizia Pellegrini, Valentina Sgroi, Mario Occhipinti, Francesca Romana DI Pietro, Alessandro Rossi, Maurizio Simmaco, Federica Mazzuca, Paolo Marchetti
BACKGROUND: Taxanes are widely used to treat breast cancer patients. Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Single-nucleotide polymorphisms (SNPs) in genes involved in taxanes' metabolism could affect the inter-individual variability in reported toxicities. MATERIALS AND METHODS: In this retrospective study, 152 women, affected by breast cancer and receiving a taxane-based chemotherapy, were enrolled...
May 2017: Anticancer Research
Masakazu Hashimoto, Tsuyoshi Kobayashi, Kohei Ishiyama, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Shintaro Kuroda, Michinori Hamaoka, Hiroshi Iwako, Sho Okimoto, Naruhiko Honmyo, Hideki Ohdan
AIM: The aim of this study was to investigate the prognostic factors associated with extrahepatic metastasis of primary hepatocellular carcinoma (HCC). PATIENTS AND METHODS: We retrospectively analyzed 559 patients with HCC who underwent curative hepatectomy. We divided the patients into no recurrence (NoR), intrahepatic early recurrence (IHER), intrahepatic late recurrence (IHLR), and extrahepatic recurrence (EHR) groups. We compared the non-metastatic group (IHLR and NoR) with the metastatic group (IHER and EHR) and also compared IHER with EHR to determine risk factors for EHR...
May 2017: Anticancer Research
Fumihiro Shoji, Gouji Toyokawa, Noboru Harada, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Tatsuro Okamoto, Yuji Soejima, Tomoharu Yoshizumi, Yoshihiko Maehara
BACKGROUND: De novo malignancy, including primary lung cancer, is one of the limitations to long-term survival after liver transplantation. The purpose of this study was to describe patients who developed de novo lung cancer after living-donor liver transplantation (LDLT) and investigate their clinicopathological features as well as the feasibility of surgical resection. PATIENTS AND METHODS: We investigated 554 patients who underwent LDLT. RESULTS: De novo lung cancer after LDLT was observed in five (0...
May 2017: Anticancer Research
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