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Anticancer Research

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July 2018: Anticancer Research
Hitomi Mori, Makoto Kubo, Masaya Kai, Kanako Kurata, Mai Yamada, Masafumi Nakamura
BACKGROUND/AIM: The dose-dense doxorubicin and cyclophosphamide (ddAC) for patients with HER-2-negative breast cancer is recommended by the National Comprehensive Cancer Network guideline in US. However, there are little data on serum G-CSF concentrations in patients undergoing bi-weekly dose-dense therapy with pegfilgrastim. The objective of this study was to compare the serum G-CSF concentrations in patients receiving pegfilgrastim in bi- or tri-weekly regimens. PATIENTS AND METHODS: This study included 26 patients who received ddAC or docetaxel and cyclophosphamide (TC) for primary breast cancer...
July 2018: Anticancer Research
Atsutomo Morishima, Hiroyuki Inagawa
BACKGROUND/AIM: The wound-healing effect of lipopolysaccharide (LPS) reportedly results from its ability to induce the removal of foreign bodies, anti-inflammatory function, and tissue-repair function. We reported the improvement of patients with protracted wound healing after the dermal administration of topical cream containing LPS derived from Pantoea agglomerans, which is a symbiotic bacterium present in wheat and confirmed as safe. PATIENTS AND METHODS: Topical cream with LPS was applied on four patients who showed protracted wound healing, after their informed consent...
July 2018: Anticancer Research
Yoichiro Yoshida, Ryohei Sakamoto, Ryuji Kajitani, Taro Munechika, Yoshiko Matsumoto, Akira Komono, Naoya Aisu, Kojima Daibo, Fumihiko Kiyomi, Suguru Hasegawa
BACKGROUND/AIM: TAS-102 has led to a significant improvement in overall survival (OS) and progression-free survival (PFS) of patients with metastatic colorectal cancer (mCRC). Neutropenia is the most common adverse event and an important factor impacting chemotherapy continuation. In this retrospective study, factors associated with grade ≥3 neutropenia, that is frequently observed in TAS-102-treated patients, were examined. PATIENTS AND METHODS: The medical records of 41 patients with CRC who received TAS-102 between October 2014 and June 2017 at the Fukuoka University Hospital were retrospectively reviewed...
July 2018: Anticancer Research
Shuichi Izumoto, Masaharu Miyauchi, Takayuki Tasaki, Takeshi Okuda, Nobuhiro Nakagawa, Naoki Nakano, Amami Kato, Mitsugu Fujita
BACKGROUND/AIM: Excessive extracellular glutamate activates AMPA-type glutamate receptors (AMPA receptors) and induces seizures. Antagonistic activation of AMPA receptors inhibits epilepsy and glioma growth in in vitro and in vivo studies. This study was conducted to evaluate the clinical impacts of perampanel (PER), a novel AMPA receptor antagonist, on seizures and tumor progression in glioma patients with uncontrollable epilepsy. PATIENTS AND METHODS: Twelve glioma patients with uncontrollable epilepsy were treated with PER...
July 2018: Anticancer Research
Kaori Makita, Takashi Kamigaki, Sachiko Okada, Eriko Matsuda, Hiroshi Ibe, Eri Oguma, Keiko Naitoh, Rishu Takimoto, Shigenori Goto
BACKGROUND/AIM: The past 17 years, immune-cell therapy has been administered to 990 patients with advanced or recurrent pancreatic adenocarcinoma and 50 patients with curatively resected pancreatic adenocarcinoma. MATERIALS AND METHODS: The correlation between overall survival (OS) and various factors including sex, age, performance status (PS), distant metastasis, chemotherapy, radiotherapy, and type of immune-cell therapy were evaluated by univariate and multivariate analyses...
July 2018: Anticancer Research
Daisuke Izuchi, Satoshi Fukagawa, Fusanori Yotsumoto, Koichiro Shigekawa, Kenichi Yoshikawa, Toyofumi Hirakawa, Chihiro Kiyoshima, Nam Sung Ouk, Daichi Urushiyama, Takahiro Katsuda, Kohei Miyata, Tomohiro Ito, Masamitsu Kurakazu, Ryota Araki, Ayako Sanui, Daisuke Miyahara, Masaharu Murata, Hiroko Ito, Kyoko Shirota, Masahide Kuroki, Shin'ichiro Yasunaga, Shingo Miyamoto
BACKGROUND/AIM: Many anticancer agents including molecularly-targeted drugs have been developed for ovarian cancer. However, the prognosis of recurrent ovarian cancer remains extremely poor. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is reported as a rational target for ovarian cancer therapy. Moreover, serum HB-EGF expression is recognized as a biomarker in patients with primary ovarian cancer. MATERIALS AND METHODS: We analysed serum samples with recurrent ovarian cancer at the Fukuoka University Hospital from April 2009 to March 2014...
July 2018: Anticancer Research
Hiroyuki Inagawa, Toshiyuki Saika, Naoki Nishiyama, Takashi Nisizawa, Chie Kohchi, Maya Uenobe, Gen-Ichiro Soma
BACKGROUND/AIM: Dewaxed brown rice has macrophage activation ability via TLR4 and contains a high amount of lipopolysaccharides (LPS). It is expected that dewaxed brown rice can help prevent lifestyle diseases. In this study, the anti-obesity effect of dewaxed brown rice was investigated using obese and diabetic model mice. MATERIALS AND METHODS: Dewaxed brown rice and white rice were polished and powdered by Toyo Rice Co. Diet pellets were prepared (AIN-93) with 50% dewaxed brown rice or white rice powder and fed to type II diabetic model KK-Ay mice for 10 weeks...
July 2018: Anticancer Research
Akira Arimoto, Kimihiro Yamashita, Hiroshi Hasegawa, Yutaka Sugita, Eiji Fukuoka, Tomoko Tanaka, Satoshi Suzuki, Yoshihiro Kakeji
BACKGROUND/AIM: Perioperative intra-abdominal infection has been reported as a risk factor for metastasis. The aim of this study was to investigate the mechanism by which peritonitis induces immunosuppression in the lung, which in turn promotes lung metastasis. MATERIALS AND METHODS: C57BL/6 mice were intravenously administered B16F10 melanoma cells to induce lung metastasis and subsequently subjected to cecal ligation and puncture (CLP) to induce peritonitis or sham surgery...
July 2018: Anticancer Research
Yuki Abe, Hirohito Kobayashi, Yoshika Akizawa, Ken Ishitani, Kazunori Hashimoto, Hideo Matsui
BACKGROUND/AIM: Malignant ascites contain many tumour-infiltrating lymphocytes. γδ T cells with antitumour activity have attracted attention as effector cells in cancer immunotherapy. Vδ2 + T cells were cultured from peripheral blood mononuclear cells (PBMCs) and ascites-infiltrating lymphocytes (AILs) to compare the differences in response to 2-methyl-3-butenyl-1-pyrophosphate (2M3B1-PP) and zoledronate (Zol) as antigens in vitro. MATERIALS AND METHODS: To expand Vδ2 + T cells from PBMCs and AILs from 29 patients with cancer, these cells were cultured and subjected to analysis...
July 2018: Anticancer Research
Qing Tang, Masayoshi Onitsuka, Atsushi Tabata, Toshifumi Tomoyasu, Hideaki Nagamune
BACKGROUND/AIM: Recombinant antibodies have been investigated and used in applications such as targeting modules of drug-delivery systems (DDS) against cancers. This study aimed to prepare recombinant antibodies against HER2, containing sortase A (SrtA) recognition sequence, that are applicable as targeting modules in DDS after linkage with the drug-carrier containing oligoglycine-acceptor peptide by SrtA transpeptidation. MATERIALS AND METHODS: The recombinant trastuzumab fragment antibodies (scFvs and Fab) with the SrtA-recognition motif (LPXTG) at their C-terminal were constructed and expressed in Escherichia coli and Chinese hamster ovary (CHO) cells, respectively...
July 2018: Anticancer Research
Tomoko Kaneko, Masahide Tominaga, Risa Kouzaki, Ayaka Hanyu, Kazuki Ueshima, Hisatsugu Yamada, Masaki Suga, Tomohiro Yamashita, Tomoaki Okimoto, Yoshihiro Uto
BACKGROUND/AIM: Carbon-ion beam is one of the most advanced radiations used for cancer treatment. However, there are tumors that are difficult to suppress with carbon-ion beam alone, thus necessitating development of drugs that can enhance its therapeutic effect. In this regard, the radiosensitizing effect of 5-aminolevulinic acid (ALA) and protoporphyrin IX (PpIX), that is a metabolic intermediate of ALA, on carbon-ion beam was investigated. MATERIALS AND METHODS: Radiosensitizing activity, mitochondrial ROS and DNA double-strand break production of ALA and PpIX were evaluated by irradiation with 1...
July 2018: Anticancer Research
Hironobu Uchiyama, Ken-Ichi Komatsu, Akifumi Nakata, Keisuke Sato, Yoshihiro Mihara, Akira Takaguri, Takayuki Nagashima, Koji Wakame
BACKGROUND/AIM: Mulberry (Morus alba L.) leaves (ML) contain many functional components, such as 1-deoxynojirimycin, flavonoids (rutin, quercetin, kaempferol). It is well known that 1-deoxynojirimycin functions to suppress increases in blood glucose level by α-glucosidase inhibitory activity. Thus, the molecular mechanism underlying the protective and therapeutic effects of ML supplementation was investigated on a mouse model of high-calorie diet (Western diet: WD)-induced hepatic steatosis (HS)...
July 2018: Anticancer Research
Toru Tasaka, Emi Kuwada, Yuka Izuchi, Ryohei Nishigawa, Hisatsugu Yamada, Hideki Unuma, Ken Tokunaga, Akio Hayakawa, Akiteru Go, Kikyo Go, Yoshihiro Uto
BACKGROUND/AIM: Whey protein is a mixture of globulins isolated from whey and mainly composed of β-lactoglobulin, α-lactoalbumin, and lactoferrin. In this study, whey protein was hydrolyzed using various proteases, and the macrophage activation was evaluated. MATERIALS AND METHODS: Hydrolyzed whey protein was prepared using various proteases to evaluate phagocytic activity and cytokine productivity. RESULTS: The results of SDS-PAGE and gel permeation chromatography (GPC) analysis indicated that the molecular weight of whey protein was reduced using various proteases...
July 2018: Anticancer Research
Riho Mashiba, Mami Ishikawa, Y U Sumiya, Kumpei Kawakatsu, Ngoc Kiet Tran, Takahito Nishikata
BACKGROUND/AIM: Serum-derived macrophage activating factor (serum MAF) is known to increase the phagocytic activity of macrophages and potentially plays a role in activating cancer immunity. In order to reveal the contributing factors for phagocytic activation, the migratory activity and the efficiency of engulfment was analyzed. MATERIALS AND METHODS: THP-1 macrophages were induced by 12-O-tetradecanoyl-13-acetate (TPA). The migratory activity and efficiency of engulfment were analyzed by time-lapse imaging and suspension assay, respectively...
July 2018: Anticancer Research
Ran Zhang, Hiroyuki Inagawa, Kimiko Kazumura, Hiroshi Tsuchiya, Toshiyuki Miwa, Naokazu Morishita, Sachiko Uchibori, Jun Hanashiro, Tsutomu Masaki, Hideki Kobara, Gen-Ichiro Soma
BACKGROUND/AIM: A system is being developed that can be used to easily evaluate the health condition of an individual with the help of trace amounts of a blood sample by focusing on xenobiotics. The system is called "Multimodal homeostasis evaluation system" (measurement of neutrophil activity, phagocytic activity of phagocytes and quantification of oxidized LDL (OxLDL)). To elucidate the possibility of using this system as an evaluation system for the health condition of an individual, clearly explaining the changes in various diseases is essential...
July 2018: Anticancer Research
Toshihiro Tanaka, Hiroaki Uchida
BACKGROUND/AIM: Survivin expression has been shown to be associated with cancer progression, poor prognosis, and drug resistance. The aim of this study was to examine whether survivin knock-down could enhance paclitaxel-induced apoptosis in breast cancer cells in vitro. MATERIALS AND METHODS: MCF-7 cells were infected with an siRNA-expressing adenovirus vector against survivin (Adv-siSurv) or Renilla luciferase as a control (Adv-siRL). After treatment with paclitaxel, cells were analyzed by apoptotic, cell cycle and immunoblotting assays...
July 2018: Anticancer Research
Makoto Kubo, Masayo Umebayashi, Kanako Kurata, Hitomi Mori, Masaya Kai, Hideya Onishi, Mitsuo Katano, Masafumi Nakamura, Takashi Morisaki
BACKGROUND/AIM: Epithelial cell adhesion molecule (EpCAM) is expressed in various types of cancer, including breast cancer, and is correlated with metastasis, invasion, therapeutic resistance and prognosis. Moreover, several cell surface markers, such as CD44 and EpCAM, are molecular targets on cancer stem-like cells of breast cancer. The aim of this study was to investigate whether catumaxomab, a clinical-grade bispecific antibody that binds to both EpCAM on tumor cells and CD3 on T-cells, combined with activated T-cells can eliminate chemoresistant triple-negative breast cancer (TNBC) cells in vitro...
July 2018: Anticancer Research
Nobuhiro Torata, Makoto Kubo, Daisuke Miura, Kenoki Ohuchida, Yusuke Mizuuchi, Yoshinori Fujimura, Eisuke Hayakawa, Masaya Kai, Yoshinao Oda, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura
BACKGROUND/AIM: Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MALDI-MSI). MATERIALS AND METHODS: A total of 119 breast tissues (84 carcinoma and 35 normal) were used. MSI data were extracted from each tissue. RESULTS: Overall, 185 of 1,915 peaks which were commonly detected in 60% of target areas were subjected to further analysis...
July 2018: Anticancer Research
Yoko Takahashi, Makoto Hamasaki, Mikiko Aoki, Kaori Koga, Naohiko Koshikawa, Shingo Miyamoto, Kazuki Nabeshima
BACKGROUND/AIM: Erythropoietin-producing hepatocellular receptor-2 (EphA2) is overexpressed in ovarian cancer. The N-terminals of EphA2 are processed by membrane-type 1 matrix metalloproteinase (MT1-MMP) and can subsequently induce ligand-independent signal activation to promote motility, invasion, and metastasis. The aim of this study was to investigate whether EphA2 processing occurs in benign, borderline, and malignant ovarian tumours. MATERIALS AND METHODS: Overall 107 ovarian epithelial carcinomas (OECs; 47 serous, 24 endometrioid, 16 mucinous, and 20 clear cell), 54 ovarian borderline tumours (OBTs; 12 serous, 42 mucinous), and 45 adenomas (15 serous, 17 mucinous, and 13 endometriotic cysts) were evaluated...
July 2018: Anticancer Research
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