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Anticancer Research

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https://www.readbyqxmd.com/read/30396993/behavioral-neurobiology-of-ptsd
#1
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396992/the-heterogeneity-of-cancer-metabolism
#2
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396991/genetic-epidemiology-methods-and-protocols
#3
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396990/book-reviews
#4
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396989/patterns-of-recurrence-after-salvage-radiotherapy-encompassing-pelvic-lymphatics-in-men-with-high-risk-prostate-cancer
#5
Minji Koh, Young Seok Kim, Hanjong Ahn, Choung-Soo Kim
BACKGROUND/AIM: The efficacy of adjuvant or salvage radiation to the regional lymph node area has not been fully investigated in high-risk prostate cancer patients; instead, radiotherapy is limited to the prostate fossa. The present study aimed to assess patterns of recurrence in prostate cancer patients with biochemical failure (BCF) who were treated with whole-pelvic salvage radiotherapy (SRT) following radical prostatectomy. PATIENTS AND METHODS: The clinical data from 196 high-risk prostate cancer patients who received SRT for BCF after radical prostatectomy were reviewed...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396988/risk-factors-for-regional-and-systemic-metastases-in-patients-with-sentinel-lymph-node-negative-melanoma
#6
Michael Erdmann, Dominic Sigler, Ugur Uslu, Jonas Göhl, Robert Grützmann, Gerold Schuler, Vera Schellerer
BACKGROUND: Sentinel lymph node status is a strong prognostic factor in melanoma. However, up to 21% of sentinel lymph node-negative patients develop locoregional and distant metastases during follow-up. AIM: To analyze risk factors for locoregional and distant metastasis in patients with sentinel lymph node-negative melanoma. PATIENTS AND METHODS: A total of 545 patients underwent sentinel lymph node biopsy (SNB) between 2005 and 2013 at our hospital...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396987/subcutaneous-trastuzumab-combined-with-pertuzumab-and-docetaxel-as-first-line-treatment-of-advanced-her2-positive-breast-cancer
#7
Dimitra Stefanou, Stefania Kokkali, Elli-Sophia Tripodaki, Maria Drizou, Elpida Magou, Dimosthenis Zylis, Maria Prevezanou, Matthaios Kapiris, Despoina Nasi, Anna Ntokou, Mary Dede, Alexandros Ardavanis
BACKGROUND/AIM: Subcutaneous (s.c.) trastuzumab was introduced in the (neo)adjuvant setting, based on the non-inferiority results and patient preference. In the advanced setting, preliminary safety data have only been reported. We conducted an observational study of s.c. trastuzumab in combination with i.v. pertuzumab and docetaxel in the first-line setting of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. PATIENTS AND METHODS: In this single-institution study, patients received 600 mg s...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396986/case-report-of-a-patient-with-breast-metastasis-from-gastric-cancer-treated-with-paclitaxel-and-ramucirumab-plus-regional-hyperthermia
#8
Jessica Lucchetti, Vincenzo Formica, Greta Giuliano, Deborah Coletta, Letizia Gargano, Daniele Morosetti, Pierpaolo Sileri, Giampiero Palmieri, Mario Roselli
BACKGROUND: Breast metastases from extra mammary tumors are extremely rare. CASE REPORT: Here we report the case of a 50-year-old female with histologically-confirmed gastric cancer metastasis to the breast who was adequately treated with loco-regional hyperthermia plus standard second-line chemotherapy (paclitaxel plus ramucirumab). The best response achieved was a relatively long disease stabilization. CONCLUSION: Chemotherapy plus regional hyperthermia has been shown to have a synergistic antitumor effect and possible favorable immunomodulatory effects...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396985/hsp27-aldh6a1-and-prohibitin-act-as-a-trio-biomarker-to-predict-survival-in-late-metastatic-prostate-cancer
#9
Sung Yong Cho, Suki Kang, Dong Su Kim, Hyung Jin Na, Ye Jin Kim, Young Deuk Choi, Nam Hoon Cho
BACKGROUND/AIM: The aim of this study was to evaluate the usefulness of biomarkers related to prostate cancer metastasis and survival of patients. MATERIALS AND METHODS: Proteomics were used for detecting significant differences in protein expression among normal prostate, localized prostate cancer and metastatic cancer using 2-dimensional gel electrophoresis and mass spectrometry. mRNA expression was then examined in order to further confirm significant differences in protein expression...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396984/negative-impact-of-coexisting-interstitial-lung-disease-on-clinical-outcomes-in-small-cell-lung-cancer-patients
#10
Kimitaka Akaike, Koichi Saruwatari, Hiroko Okabayashi, Shohei Hamada, Yasumiko Jodai, Takayuki Jodai, Shinya Sakata, Shinji Iyama, Ryo Sato, Toyohisa Iriki, Yusuke Tomita, Sho Saeki, Hidenori Ichiyasu, Kazuhiko Fujii
BACKGROUND/AIM: The impact of interstitial lung disease (ILD) on the clinical outcome of patients with small-cell lung cancer (SCLC) is not fully understood. The aim of this study was to investigate the impact of ILD on treatment and survival outcomes of SCLC patients. PATIENTS AND METHODS: A retrospective analysis was performed on the clinical outcomes of SCLC patients, treated with chemotherapy, with or without ILD ([ILD group (n=16) and non-ILD group (n=51)]...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396983/feasibility-of-combination-therapy-with-nab-paclitaxel-plus-gemcitabine-in-patients-with-recurrent-pancreatic-cancer
#11
Hiromichi Kawaida, Hiroshi Kono, Hidetake Amemiya, Ryou Saitou, Atsushi Yamamoto, Naohiro Hosomura, Mitsuaki Watanabe, Ayako Kimura, Shinji Furuya, Hiroki Shimizu, Hidenori Akaike, Yoshihiko Kawaguchi, Makoto Sudo, Jun Itakura, Hiroshi Hayakawa, Hiroko Shindo, E I Takahashi, Shinichi Takano, Mitsuharu Fukasawa, Shintaro Ichikawa, Hideki Fujii, Daisuke Ichikawa
BACKGROUND/AIM: Nab-paclitaxel plus gemcitabine (nab-P+Gem) is one of most reliable and effective regimens for borderline or unresectable pancreatic cancer (PC). However, the feasibility and clinical benefits of this regimen have never been evaluated for patients with recurrent PC after pancreatectomy. The aim of this study was to investigate the feasibility of combination therapy with nab-paclitaxel plus gemcitabine (nab-P+Gem) for patients with recurrent PC. PATIENTS AND METHODS: Twenty-two patients with recurrent PC received an intravenous infusion of nab-P (125 mg/m2 ) and Gem (1,000 mg/m2 ) on days 1, 8, and 15 of a 4-week cycle...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396982/aggressive-cancer-behavior-of-latent-gleason-pattern-5-in-prostatectomy-specimens
#12
Tetsuya Fujimura, Hiroshi Fukuhara, Yuta Yamada, Satoru Taguchi, Toru Sugihara, Aya Niimi, Masaki Nakamura, Tohru Nakagawa, Yasuhiko Igawa, Yukio Homma, Haruki Kume
BACKGROUND/AIM: The aim of this study was to demonstrate the clinical significance of latent Gleason pattern (GP) 5 occasionally found in prostatectomy specimens. MATERIALS AND METHODS: Patients (n=605) undergoing radical prostatectomy were classified into three groups according to the presence of GP5 in the biopsy or in the prostatectomy specimens: 'GP5 negative', absence of GP in both specimens 'latent GP5', absence of GP5 in the biopsy specimen, but presense of GP5 in the prostatectomy specimen, and 'GP5 positive', presense of GP in both specimens...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396981/the-potential-use-of-a-ketogenic-diet-in-pancreatobiliary-cancer-patients-after-pancreatectomy
#13
Ju Hye Ok, Hosun Lee, Hae-Yun Chung, Sung Hwan Lee, Eun Jeong Choi, Chang Moo Kang, Song Mi Lee
BACKGROUND/AIM: High-carbohydrate diets are generally provided to post-pancreatectomy cancer patients. Low energy density of this diet may obstruct proper energy intake and recovery. This study aimed to assess the effects of high-fat, high-energy ketogenic diet (KD) in these patients. PATIENTS AND METHODS: After pancreatectomy, 9 patients were provided with general diet (GD) while 10 were served KD. Meal compliance, energy intake rate, meal satisfaction and presence of complications were monitored throughout hospital stay...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396980/relationship-between-postoperative-crp-and-prognosis-in-thoracic-esophageal-squamous-cell-carcinoma
#14
Keita Katsurahara, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Kazuma Okamoto, Eigo Otsuji
BACKGROUND/AIM: Few studies have examined postoperative CRP in esophageal cancer. We investigated the relationship between postoperative CRP values according to the postoperative period and prognosis in esophageal cancer. PATIENTS AND METHODS: We performed a retrospective cohort study including 187 patients who underwent esophagectomy for esophageal squamous cell carcinoma (ESCC) between January 2008 and October 2016. RESULTS: CRP within 1 month of surgery was not related to overall survival (OS) or recurrence-free survival (RFS)...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396979/comparison-of-primary-tumor-size-in-stage-i-and-iii-epithelial-ovarian-cancer
#15
COMPARATIVE STUDY
Edgar Petru, Carola Huber, Eva Sampl, Josef Haas
BACKGROUND: Two studies have found primary ovarian carcinomas in stage I disease to be larger than those in stage III. Thus, these stages may represent different tumor entities. MATERIALS AND METHODS: The clinical data from 553 patients operated on between 1985 and 2012 for epithelial ovarian cancer were retrospectively analyzed. RESULTS: Primary lesions including invasive, borderline and benign components were significantly larger in stage I compared to stage III disease (p<0...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396978/morphologic-response-and-tumor-shrinkage-as-early-predictive-markers-in-unresectable-colorectal-liver-metastases
#16
Toshiki Masuishi, Hiroya Taniguchi, Tetsuya Eto, Azusa Komori, Seiichiro Mitani, Hiroko Hasegawa, Yukiya Narita, Makoto Ishihara, Tsutomu Tanaka, Shigenori Kadowaki, Takashi Ura, Masashi Ando, Masahiro Tajika, Motoo Nomura, Yozo Sato, Hideyuki Mishima, Kei Muro
BACKGROUND/AIM: Anti-EGFR antibodies or bevacizumab comprise first-line treatment for patients with RAS wild-type colorectal liver metastases (CLM). Which marker better predicts efficacy, early tumor shrinkage or morphologic response, still remains unclear. PATIENTS AND METHODS: We retrospectively evaluated 155 patients with KRAS exon 2 wild-type CLM treated with bevacizumab (BEV group) or anti-EGFR antibodies (EGFR group). Three radiologists independently assessed early tumor shrinkage (ETS) and early optimal morphologic response (EOMR) from baseline and first follow-up CT scan...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396977/c-reactive-protein-based-prognostic-measures-are-superior-at-predicting-survival-compared-with-peripheral-blood-cell-count-based-ones-in-patients-after-curative-resection-for-pancreatic-cancer
#17
COMPARATIVE STUDY
Yuki Fujiwara, Koichiro Haruki, Hiroaki Shiba, Ryoga Hamura, Takashi Horiuchi, Yoshihiro Shirai, Kenei Furukawa, Takeshi Gocho, Katsuhiko Yanaga
AIM: Prognostic factors of recurrence and survival in various cancer types have been reported and include C-reactive protein (CRP)-based measures as evidenced by the Glasgow prognostic score (GPS), as well as peripheral blood cell-based prognostic values such as the prognostic index (PI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). The aim of this study was to identify significant prognostic values and compare them for suitability for use in patients after curative pancreatic resection for pancreatic cancer...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396976/primary-tumor-size-predicts-distant-metastasis-of-mucosal-malignant-melanoma-in-head-and-neck
#18
Hidenori Suzuki, Gaku Takano, Nobuhiro Hanai, Daisuke Nishikawa, Yusuke Koide, Shintaro Beppu, Yasuhisa Hasegawa
BACKGROUND/AIM: To investigate the possible association between primary tumor size and overall survival and/or distant metastasis-free survival of patients with mucosal malignant melanoma of the head and neck. PATIENTS AND METHODS: A total of 25 patients that have had primary tumor resection were enrolled in this study. Primary tumor size was assessed as the maximum size of the primary tumor in pathological and surgical reports. RESULTS: Patients with a primary tumor size of ≥43 mm showed a significant association with shorter overall survival (p=0...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396975/plasma-catalase-in-relation-to-pain-following-midline-laparotomy-a-prospective-study-of-patients-with-benign-diseases-and-patients-with-cancer
#19
Iina Saimanen, Jari Kärkkäinen, Tuomas Selander, Martin Purdy, Merja Kokki, Hannu Kokki, Matti Eskelinen
BACKGROUND/AIM: The relationship of plasma concentrations of the oxidative stress biomarker catalase with pain on numeric rating scale at rest (NRSr) and under wound pressure 24 hours postoperatively (NRSp) in midline laparotomy patients with rectus sheath block (RSB) analgesia are unknown. Our original hypothesis was that RSB analgesia might reduce postoperative pain. PATIENTS AND METHODS: Initially, 56 patients were randomized to four groups: control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30396974/prognostic-significance-of-conversion-surgery-following-first-or-second-line-chemotherapy-for-unresectable-gastric-cancer
#20
Minoru Fukuchi, Erito Mochiki, Toru Ishiguro, Youichi Kumagai, Keiichiro Ishibashi, Hideyuki Ishida
BACKGROUND/AIM: Advances in chemotherapy for gastric cancer have encouraged surgeons to perform conversion surgery following a response to first-line chemotherapy in patients with initially unresectable gastric cancer. In this study we evaluated the efficacy of conversion surgery following first- or second-line chemotherapy for unresectable gastric cancer. PATIENTS AND METHODS: We retrospectively analyzed clinicopathological and survival data of 94 patients with unresectable gastric cancer treated with first- (n=94) or second-line (n=43) chemotherapy...
November 2018: Anticancer Research
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