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Anticancer Research

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https://www.readbyqxmd.com/read/28551685/concordance-of-her2-immunohistochemistry-and-fluorescence-in-situ-hybridization-using-tissue-microarray-in-breast-cancer
#1
Daniela Furrer, Simon Jacob, Chantal Caron, François Sanschagrin, Louise Provencher, Caroline Diorio
AIM: Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are common methods for assessment of human epidermal growth factor receptor 2 (HER2) in breast cancer. MATERIALS AND METHODS: In a cohort of 498 consecutive patients with breast cancer, we examined concordance between IHC and FISH for HER2 on tissue microarray (TMA) sections. In a subset of 116 specimens, we examined HER2 concordance from the block used for diagnostics and a randomly-chosen additional block (a proxy of the core biopsy)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551684/exhaled-breath-condensate-acidification-occurs-during-surgery-for-abdominal-cancer
#2
Archontia Mahairidou, Sophia Rodopoulou, Ioannis Tomos, Eirini Maratou, Effrosyni Manali, Thomas Raptakis, Spyros A Papiris, Anna Karakatsani
BACKGROUND/AIM: Acidification of exhaled breath condensate (EBC), reflecting airway inflammation and oxidative stress, has been reported in lung cancer patients undergoing lobectomy. We undertook this study to examine EBC pH changes during surgery for abdominal cancer. PATIENTS AND METHODS: EBC pH was measured from 20 patients undergoing abdominal cancer resection before and during surgery. Repeated-measures of ANOVA and random-effects linear models were applied to compare mean EBC pH values in samples collected at different times...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551683/jc-virus-and-lung-adenocarcinoma-fact-or-myth
#3
Emanuele Sinagra, Dario Raimondo, Elena Gallo, Mario Stella, Mario Cottone, Francesca Rossi, Marco Messina, Massimiliano Spada, Giovanni Tomasello, Giuseppe Ferrara, Aroldo Gabriele Rizzo
BACKGROUND/AIM: An association has been reported between lung cancer and John Cunningham (JC) virus infection. The aim of this study was to evaluate the prevalence of JC virus in a small cohort of patients with lung adenocarcinoma and assess its presence in nodal metastasis. MATERIALS AND METHODS: Consecutive samples of 13 surgically-removed lung tumors and 13 surrounding normal cancer-free tissues were selected. Five cases included metastatic lymph nodes. JC virus infection was assessed through nested PCR...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551682/surgical-outcomes-of-non-small-cell-lung-cancer-in-patients-with-a-history-of-pancreaticobiliary-cancer
#4
Tetsuzo Tagawa, Kensaku Ito, Kengo Fukuzawa, Tatsuro Okamoto, Atsuro Fujinaga, Takahide Kawasaki, Takashi Masuda, Kentaro Iwaki, Takahiro Terashi, Masahiro Okamoto, Akio Shiromizu, Akira Motohiro, Yoshihiko Maehara
AIM: To determine the efficacy of surgery for non-small cell lung cancer in patients who had previously undergone surgery for pancreaticobiliary cancer. PATIENTS AND METHODS: Seven patients who underwent pulmonary resection for primary lung cancer after curative surgery for pancreaticobiliary cancer at our Institution from 2006 to 2016 were retrospectively evaluated. RESULTS: Five patients had metachronous and two patients had synchronous cancer of pancreaticobiliary and lung origin...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551681/neoadjuvant-chemoradiotherapy-for-stage-ii-or-iii-esophageal-squamous-cell-carcinoma
#5
Takaharu Kawai, Mitsugu Kochi, Masashi Fujii, Keio Song, Ken Hagiwara, Megumu Watanabe, Yoritaka Matsuno, Hiroshi Suda, Renpei Yagi, Tadatoshi Takayama
BACKGROUND/AIM: The goal of this retrospective study was to investigate the efficacy and safety of neoadjuvant chemoradiotherapy (CRT) in patients with Stage II or Stage III esophageal squamous cell carcinoma (SCC). PATIENTS AND METHODS: Between January 2004 and December 2014, a total of 86 patients underwent surgical resection in conjunction with preoperative CRT for esophageal SCC in our Institute. RESULTS: A pathological complete response was achieved in 38...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551680/rt-pcr-for-detecting-alk-translocations-in-cytology-samples-from-lung-cancer-patients
#6
Shinji Nakamichi, Masahiro Seike, Akihiko Miyanaga, Mika Chiba, Kuniko Matsuda, Kenichi Kobayashi, Akiko Takahashi, Susumu Takeuchi, Yuji Minegishi, Kaoru Kubota, Akihiko Gemma
BACKGROUND/AIM: We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS: We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer patients diagnosed at the Nippon Medical School Hospital between 2013 and 2015. Immunochemistry (IHC) and break-apart fluorescence in situ hybridization (FISH) were also performed on available tissue samples...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551679/multiparametric-mri-trus-fusion-prostate-biopsy-advantages-of-a-transperineal-approach
#7
Pietro Pepe, Antonio Garufi, Gian Domenico Priolo, Michele Pennisi
BACKGROUND/AIM: To evaluate the detection rate for clinically-significant prostate cancer (PCa) of transperineal (TP) vs. transrectal (TR) multiparametric MRI/TRUS (magnetic resonance imaging/transrectal ultrasound) fusion targeted-biopsy. PATIENTS AND METHODS: From January 2016 to December 2016, 150 men underwent repeat saturation transperineal prostate biopsy (SPBx; median 30 cores) combined with targeted mpMRI/TRUS TR and TP fusion biopsies (4 cores for each procedure) of suspicious MRI lesions (PI-RADS 3/5)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551678/radiotherapy-of-primary-or-recurrent-bladder-cancer-in-the-very-elderly
#8
Stefan Janssen, Lisa Manig, Steven E Schild, Dirk Rades
AIM: The number of very elderly patients with cancer is growing and requires particular attention. The role of organ-sparing irradiation in patients with bladder cancer aged ≥80 years was investigated. PATIENTS AND METHODS: In 29 very elderly (≥80 years) patients irradiated for bladder cancer, 12 characteristics were analysed for survival: indication, gender, age, Karnofsky performance score (KPS), T-/N-category, tumour grade, pack years, smoking during irradiation, radiation dose, interruption of irradiation >5 days and concurrent chemotherapy...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#9
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551676/hodgkin-lymphoma-transformation-of-chronic-lymphocytic-leukemia-under-ibrutinib-therapy-chance-association-or-therapy-related
#10
Sotirios Sachanas, Gerassimos A Pangalis, Maria Moschogiannis, Xanthi Yiakoumis, Efstathios Koulieris, Pantelis Tsirkinidis, Christina Kalpadakis, Dimitra Rontogianni
The established treatment algorithms for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) are currently challenged by novel classes of drugs, with ibrutinib being one of the most effective. Published data suggest that patients with early progression under ibrutinib often emerge as having Richter's transformation (RT) with a rapidly fatal prognosis, mostly developing diffuse large B-cell lymphoma (DLBCL). In this respect, it is known that RT to large DLBCL occurs in about 5% of patients with CLL during the disease course and less frequently to Hodgkin lymphoma (HL)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551675/urinary-tract-resections-in-advanced-stage-cervical-cancer-a-series-of-eight-cases
#11
Dana Nuti Oprescu, Nicolae Bacalbasa, Irina Balescu, Alexandru Filipescu
BACKGROUND/AIM: Cervical cancer is one of the most frequent malignancies in women worldwide and is unfortunately diagnosed in advanced stages of the disease. Whenever local invasion is present, neoadjuvant therapy might be needed in order to limit the degree of local invasion. However, in certain cases local invasion persists even after completing the neoadjuvant radiochemotherapy; in these patients more extensive resections might be needed in order to achieve a radical resection. PATIENTS AND METHODS: We present a case series of eight patients in whom segmental ureteral or uretero-vesical resections were performed as part of the radical resections for locally advanced cervical tumors...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551674/an-alternative-surgery-for-an-atypical-kind-of-grade-c-postoperative-pancreatic-fistula-following-pancreaticoduodenectomy
#12
Edoardo Virgilio, Marco LA Torre, Marco Cavallini
BACKGROUND/AIM: Grade C postoperative pancreatic fistula (POPF) is a life-threatening complication of pancreaticoduodenectomy (PD), with its surgical management remaining under debate. Occasionally, POPF is associated with a compromised anastomotic Roux-limb. Our series focused to this sort of grade C mixed fistula. PATIENTS AND METHODS: Between April 2004 and March 2014, 5 out of 12 patients with grade C POPF were classified as grade C mixed POPFs. Surgery consisted of associating resection of the anastomotic jejunal segment with resection and closure of the pancreatic stump...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551673/tissue-factor-expression-does-not-predict-mortality-in-breast-cancer-patients
#13
Simon F Stämpfli, Alexander Akhmedov, Silke Hausladen, Zsuzsanna Varga, Konstantin J Dedes, Jens Hellermann, Thomas F Lüscher, Glen Kristiansen, Felix C Tanner, Alexander Breitenstein
BACKGROUND: Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS: Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551672/ctnnb1-mutations-in-ovarian-microcystic-stromal-tumors-identification-of-a-novel-deletion-mutation-and-the-use-of-pyrosequencing-to-identify-reported-point-mutation
#14
Kiyong Na, Eun Kyung Kim, Wonjun Jang, Hyun-Soo Kim
BACKGROUND/AIM: Microcystic stromal tumor (MCST) is a rare stromal tumor of the ovary. In this study, we describe clinicopathological characteristics and results of mutational analyses of the CTNNB1gene in two cases of ovarian MCST and we provide a thorough review of previously published cases alongside our current cases and clarify the clinicopathological characteristics of ovarian MCST. PATIENTS AND METHODS: Patients' age was 33 and 31 years, respectively. One patient presented with fever and low abdominal pain, whereas a pelvic mass was incidentally detected in another patient...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551671/sarcoidosis-under-dendritic-cell-vaccination-immunotherapy-in-long-term-responding-patients-with-metastatic-melanoma
#15
Ugur Uslu, Michael Erdmann, Stefan Schliep, Jan Dörrie, Niels Schaft, Gerold Schuler, Beatrice Schuler-Thurner
Sarcoidosis, a chronic inflammatory disorder, results from increased immune responses. Its development can be triggered in patients under immunotherapy, as activation of the immune system in these patients is desired. Since 1997, 249 patients with metastasized cutaneous melanoma (stage III and IV, AJCC 2009) have been treated with dendritic cell (DC)-based vaccines at our hospital. Three out of these patients were diagnosed with sarcoidosis after or during long-term DC vaccination therapy (1.20%). Metastatic disease was initially suspected based on the radiographic manifestation of lung masses or bilateral hilar lymphadenopathy...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551670/changes-in-the-submandibular-gland-in-patients-with-head-and-neck-cancer-after-radiation-therapy-a-preliminary-study
#16
Yuka Uchiyama, Sven Kreiborg, Shumei Murakami, Tomomi Tsujimoto, Iori Sumida
AIM: The purpose of this study was to assess the impairment of the submandibular gland, in terms of changes in volume by computed tomography (CT) and CT value, which was the mean pixel value at a region of interest, in a group of patients with head and neck cancer treated with radiation therapy (RT). PATIENTS AND METHODS: Eleven patients treated with RT, where the effective radiation dose to the submandibular gland was known, were included in the study. CT scanning was performed both before and after RT...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551669/effects-of-preoperative-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-on-survival-in-patients-with-extrahepatic-cholangiocarcinoma
#17
Yuki Kitano, Yo-Ichi Yamashita, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Tatsunori Miyata, Shigeki Nakagawa, Kosuke Mima, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
BACKGROUND/AIM: As indicators of systemic inflammatory response, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) predict prognoses for various cancers. This study investigated their prognostic significance in extrahepatic cholangiocarcinoma (ECC). PATIENTS AND METHODS: We analyzed 120 patients who underwent surgery for ECC between 2000 and 2014. We calculated preoperative NLR and PLR and evaluated their correlations with patients' clinicopathological features and prognosis...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551668/occupational-risk-for-oral-cancer-in-nordic-countries
#18
Laura Tarvainen, Juho Suojanen, Pentti Kyyronen, Christian Lindqvist, Jan Ivar Martinsen, Kristina Kjaerheim, Elsebeth Lynge, Par Sparen, Laufey Tryggvadottir, Elisabete Weiderpass, Eero Pukkala
AIM: To evaluate occupational risk for cancer of the tongue, oral cavity or pharynx after adjustment for alcohol and tobacco use. MATERIALS AND METHODS: The data covered 14.9 million people and 28,623 cases of cancer of the tongue, oral cavity and pharynx in the Nordic countries 1961-2005. Alcohol consumption by occupation was estimated based on mortality from liver cirrhosis and incidence of liver cancer. Smoking by occupation was estimated based on the incidence of lung cancer...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551667/duration-of-preoperative-biliary-drainage-as-a-prognostic-factor-after-pancreaticoduodenectomy-for-pancreatic-head-cancer
#19
Michinori Matsumoto, Yukio Nakabayashi, Yuki Fujiwara, Naotake Funamizu, Rota Noaki, Seiichiro Eto, Hiroshi Sugano, Masahiko Otsuka, Katsuhiko Yanaga
BACKGROUND/AIM: Preoperative biliary drainage (PBD) is often performed for jaundiced patients. However, the optimal duration of PBD remains unknown. The aim of this study was to investigate whether duration of PBD influenced the prognosis of patients after pancreaticoduodenectomy (PD) for pancreatic head cancer. PATIENTS AND METHODS: Twenty-five patients who underwent PD for pancreatic head cancer with obstructive jaundice between 2007 and 2013 were included. Tumor and host factors were analyzed to evaluate their potential prognostic effects and patients' characteristics between the two groups according to the duration of PBD were analyzed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551666/clinical-features-and-outcome-of-surgical-patients-with-non-b-non-c-hepatocellular-carcinoma
#20
Shigeki Wakiyama, Michinori Matsumoto, Koichiro Haruki, Takeshi Gocho, Taro Sakamoto, Hiroaki Shiba, Yasuro Futagawa, Yuichi Ishida, Katsuhiko Yanaga
AIM: To investigate the clinical characteristics and prognosis of surgical patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) compared to those of hepatitis B virus (HBV)- and hepatitis C virus (HCV)-HCC. PATIENTS AND METHODS: Clinical data and outcomes were compared among the three groups. Prognostic factors of patients with NBNC-HCC were investigated. RESULTS: Compared to HBV-HCC, patients with NBNC-HCC had higher chance of hypertension (HTN) (p<0...
June 2017: Anticancer Research
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