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Anticancer Research

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https://www.readbyqxmd.com/read/28739776/phase-ii-study-of-the-efficacy-and-safety-of-high-dose-pemetrexed-in-combination-with-cisplatin-versus-temozolomide-for-the-treatment-of-non-small-cell-lung-cancer-with-brain-metastases
#1
Qiaowei He, Xizhuang Bi, Chao Ren, Yong Wang, Peng Zou, Hongtao Zhang, Nan Chi, Chunming Xiu, Yunbo Wang, Rongjie Tao
The aim of this study was to explore the efficacy and safety of high-dose pemetrexed with cisplatin versus combination with temozolomide in patients with brain metastases (BM) of lung adenocarcinoma. After standard whole-brain radiotherapy (WBRT, 30 Gy/10 fractions), patients with BM of non-small cell lung cancer (NSCLC) were given high-dose pemetrexed (900 mg/m(2)) on day 1 of each cycle (3 weeks), and cisplatin was administered on days 1-3 in the cisplatin-treated group. The temozolomide-treated group was treated as follows: 75 mg/m(2) temozolomide orally with concurrent WBRT followed by 150 mg/m(2) temozolomide on days 1-5 with high-dose pemetrexed (900 mg/m(2)) on day 1 of each cycle (3 weeks)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739775/effect-of-interventional-therapy-on-the-expression-of-survivin-mrna-in-cervical-cancer
#2
Shao-Guang Wang, Nan Mu, Hai-Yan Sun
AIM: To examine the expression of survivin mRNA in cervical squamous cancer at different time points during interventional therapy in order to find the optimal time point for continual treatment. PATIENTS AND METHODS: Fifty patients with stage IB2-IIB cervical squamous cancer receiving transarterial infusion chemotherapy and chemoembolization were included in the present study. The expression of survivin mRNA in cancer samples before and after interventional therapy (on days 7, 14 and 21) were examined by reverse transcription-polymerase chain reaction...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739774/study-of-preoperative-antiviral-treatment-of-patients-with-hcc-negative-for-hbv-dna
#3
Xiao-Fang Liu, Tong Zhang, Kun Tang, Lu-Lu Sui, Gang Xu, Qiang Liu
AIM: To study preoperative HBV-DNA negative HBV-related hepatocellular carcinoma (HCC) which was reactivated after surgery and could influence liver function and HCC recurrence. PATIENTS AND METHODS: Patients were divided into two groups according to preoperative antiviral therapy status. The control group comprised of 102 preoperative HBV-DNA-negative patients who had not undergone antiviral therapy before surgery. In the treatment group, all HBV-DNA-negative patients (n=63) received entecavir 3-5 days before surgery and for 12 months after surgery...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739773/independent-correlation-between-ki67-index-and-circulating-tumor-cells-in-the-diagnosis-of-colorectal-cancer
#4
Yingchi Yang, Jun Li, Lan Jin, Dong Wang, Jinghui Zhang, Jin Wang, Xiaomu Zhao, Guocong Wu, Hongwei Yao, Zhongtao Zhang
BACKGROUND: The Ki67 index is a biomarker of proliferation, while the circulating tumor cell (CTC) count acts as a metastasis-related biomarker. In this study, we analyzed the potential value of CTC count and Ki67 index in diagnosis of colorectal cancer (CRC). MATERIALS AND METHODS: A total of 105 patients with CRC undergoing surgery were included in the study. Isolation and identification of CTCs were performed by negative enrichment and immuno-fluorescence in situ hybridization, respectively...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739772/efficacy-and-safety-of-nab-paclitaxel-as-second-line-chemotherapy-for-locally-advanced-and-metastatic-non-small-cell-lung-cancer
#5
Wenjing Wong, Ping Sun, Zhengbin Mu, Jiannan Liu, Caiyan Yu, Aina Liu
AIM: To investigate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for locally advanced or metastatic non-small cell lung cancer (NSCLC) as second-line chemotherapy. PATIENTS AND METHODS: We retrospectively reviewed the treatment of 34 patients with advanced NSCLC whose first-line treatment had failed. These patients received nab-paclitaxel 260 mg/m(2) on day 1 and day 8 of a 21-day cycle from July 2014 to February 2016. One cycle of treatment lasted 3 weeks and all patients completed more than two cycles...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739771/clinical-characteristics-and-prognosis-of-elderly-small-cell-lung-cancer-patients-complicated-with-hyponatremia-a-retrospective-analysis
#6
Yongping Yang, Naihong Sun, Ping Sun, Liangming Zhang
AIM: This study was designed to evaluate the clinical characteristics and prognosis of elderly small cell lung cancer (SCLC) patients complicated with hyponatremia, thus providing increased attention for appropriate intervention and improving outcomes in symptomatic subjects. PATIENTS AND METHODS: The clinical data of 320 patients with SCLC in the Yuhuangding Hospital from March 1st, 2006, to March 1st, 2012, were studied retrospectively. The prognosis and possible association with hyponatremia was investigated...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739770/gastric-cancer-mortality-trends-in-china-2006-2013-reveal-increasing-mortality-in-young-subjects
#7
Jie Yin, Jian-Ning Song, Zhi-Gang Bai, Jun Cai, Jun Zhang, Zhi Zheng, Hong-Wei Wu, Peng-Peng Ye, Xin Gao, Zhong-Tao Zhang
BACKGROUND/AIM: Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to investigate the epidemiological features of GC-related mortality in China between 2006 and 2013. PATIENTS AND METHODS: GC mortality data between 2006 and 2013 were obtained from the National Disease Surveillance System published by the China Center for Disease Control and Prevention (CDC)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739769/effects-of-different-palliative-jaundice-reducing-methods-on-immunologic-functions-in-patients-with-advanced-malignant-obstructive-jaundice
#8
Kun Tang, Lu-Lu Sui, Gang Xu, Tong Zhang, Qiang Liu, Xiao-Fang Liu
BACKGROUND/AIM: This study aimed to investigate the effects of three treatment methods on the immunological function of patients with advanced malignant obstructive jaundice (MOJ). PATIENTS AND METHODS: Patients with advanced MOJ were randomly divided into three groups according to biliary drainage methods. Detection of levels of multi-indices were investigated in different time periods. RESULTS: After drainage, the levels of complement 3 (C3) and complement 4 (C4) were increased...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739768/preoperative-high-neutrophil-to-lymphocyte-ratio-is-associated-with-high-grade-bladder-cancer
#9
Xingxing Tang, Shuo Wang, Chao An, Peng DU, Yong Yang
AIM: To evaluate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and histopathological characteristics of bladder cancer. MATERIALS AND METHODS: A retrospective analysis was performed on a cohort of patients (n=302) who were diagnosed with bladder cancer and underwent transurethral resection of bladder tumor or cystectomy between 2009 and 2016. The pathological outcomes were compared between patients with low NLR and those with high NLR with a cut-off value of 2...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739767/predictors-of-malignancy-for-female-patients-with-suspicious-nipple-discharge-a-retrospective-study
#10
Liang Jin, Liling Zhu, Shunrong Li, Yinduo Zeng, Lin Haixiong, Fengxi Su, Kai Chen
BACKGROUND: Suspicious nipple discharge (ND) in females requires further treatment, including biopsy or selective duct excision. It is important to identify predictors of malignancy in female patients with suspicious ND. MATERIALS AND METHODS: This retrospective study included patients with suspicious ND who underwent surgical treatment at our center between January 2007 and December 2014. Clinicopathological features were compared between patients with and without malignancy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739766/clinical-study-on-using-125-i-seeds-articles-combined-with-biliary-stent-implantation-in-the-treatment-of-malignant-obstructive-jaundice
#11
Tao Wang, Sheng Liu, Yan-Bo Zheng, Xue-Peng Song, Bo-Lin Sun, Wen-Jin Jiang, Li-Gang Wang
Aim: To study the feasibility and curative effect of(125)I seeds articles combined with biliary stent implantation in the treatment of malignant obstructive jaundice. Patients and Methods: Fifty patients with malignant obstructive jaundice were included. Twenty-four were treated by biliary stent implantation combined with intraluminal brachytherapy by (125)I seeds articles as the experimental group, while the remaining 26 were treated by biliary stent implantation only as the control group. The goal of this study was to evaluate total bilirubin, direct bilirubin and tumor markers (cancer antigen (CA)-199, CA-242 and carcinoembryonic antigen (CEA)), as well as biliary stent patency status and survival time before and after surgery...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739765/relationship-of-th17-treg-cells-and-radiation-pneumonia-in-locally-advanced-esophageal-carcinoma
#12
Yan Wang, Gang Xu, Jie Wang, Xin-Hua Li, Ping Sun, Wei Zhang, Jun-Xia Li, Chao-Yang Wu
BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739764/mr-guided-percutaneous-biopsy-of-focal-hepatic-dome-lesions-with-free-hand-combined-with-mr-fluoroscopy-using-1-0-t-open-high-field-scanner
#13
Ligang Wang, Ming Liu, Liming Liu, Yanbo Zheng, Yujun Xu, Xiangmeng He, Peipei Li, Chengli Li
AIM: To prospectively estimate the safety, feasibility and accuracy of 1.0T open-magnetic resonance (MR)-guided percutaneous biopsy in free-hand of focal lesions located in the hepatic dome. MATERIALS AND METHODS: All percutaneous MR-guided biopsies of the lesions were performed at the Shandong Medical Imaging Research Institute. Thirty-six patients with focal liver lesions located in the hepatic dome measuring 6-36 mm in the maximum diameter were included in this study...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739763/exploration-of-the-radiotherapeutic-clinical-target-volume-delineation-for-gastric-cancer-from-lymph-node-metastases
#14
Wei Dong, Baosheng Li, Juan Wang, Yipeng Song, Zicheng Zhang, Chengrui Fu
AIM: To clarify the clinical target volume of regional lymph nodes (CTVn) delineation of gastric adenocarcinoma. MATERIALS AND METHODS: The pattern of lymph node metastases (LNM) of a total of 1,473 patients with gastric cancer (GC) who had undergone gastrectomy and lymphadenectomy with more than 15 lymph nodes retrieved was retrospectively examined. RESULTS: A univariate analysis showed that T stage (p<0.001), macroscopic type (p=0.001), tumor differentiation (p<0...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739762/comparison-of-efficiency-of-video-endoscopy-and-open-inguinal-lymph-node-dissection
#15
Shuo Wang, Peng DU, Xingxing Tang, Chao An, Ning Zhang, Yong Yang
AIMS: To compare the efficiency and complications of video endoscopy, inguinal lymphadenectomy and open inguinal lymph node dissection. PATIENTS AND METHODS: Nineteen video endoscopy inguinal lymphadenectomies were performed on 16 patients from September 2014 to December 2015, and 21 open inguinal lymph node dissections were performed on 18 patients from September 2013 to September 2014. Surgical time, operative blood loss, incidence of complications, length of stay, lymph node harvest and suture removal time were compared between the two groups...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739761/the-prognostic-value-of-the-8th-edition-of-the-american-joint-committee-on-cancer-ajcc-staging-system-in-her2-enriched-subtype-breast-cancer-a-retrospective-analysis
#16
Bin Zhou, Ling Xu, Jingming Ye, Ling Xin, Xuening Duan, Yinhua Liu
BACKGROUND/AIM: The American Joint Committee on Cancer (AJCC) released its 8th edition of tumor staging which is to be implemented in early 2018. The present study aimed to analyze the prognostic value of AJCC 8th edition Cancer Staging System in HER2-enriched breast cancer, on a retrospective cohort. PATIENTS AND METHODS: This study was a retrospective single-center study of HER2-enriched breast cancer cases diagnosed from January 2008 to December 2014. Clinicopathological features and follow up data including disease-free survival (DFS) and overall survival (OS) were analyzed to explore prognostic factors for disease outcome...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739760/cyclosporin-a-reversed-chemoresistance-of-a-patient-with-pure-red-cell-aplasia-secondary-to-thymoma
#17
Peng Li, Fengcai DU, Zhaohua Gong, Baohong Hu, Cheng Chi, Hongjin Chu, Jian Chen
This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered to treat aplasia, could reverse chemoresistance. Its mechanism is not completely clear, but the hypothesis of CsA inhibiting P-glycoprotein mediated drug efflux is the most acceptable.
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739759/explored-risk-factors-for-lymph-node-metastasis-with-siewert-ii-iii-adenocarcinoma-of-the-gastroesophageal-junction
#18
Zhi Zheng, Jie Yin, Hong-Wei Wu, Jun Li, Jun Cai, Sheng-Qi Qin, Jun Zhang, Hong-Wei Yao, Jian-She Li, Zhong-Tao Zhang
AIM: To explore the risk factors and prognosis for lymphatic metastasis (LNM) in patients with Siewert II/III adenocarcinoma of the gastroesophageal junction (AEG). PATIENTS AND METHODS: This study retrospectively reviewed 49 patients with Siewert II/III AEG. Clinical characteristics and pathological features were analyzed by the Chi-square the and binary logistic regression. Survival data were analyzed using the Kaplan-Meier method. RESULTS: LNM frequency was found in lymph nodes No...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739758/laparoscopic-assisted-transanal-total-mesorectal-excision-for-middle-low-rectal-carcinoma-a-clinical-study-of-19-cases
#19
Hong-Wei Yao, Guo-Cong Wu, Ying-Chi Yang, Lan Jin, Zhi-Peng Zhang, Ning Chen, Zhong-Tao Zhang
AIM: To explore the safety, feasibility and short-term outcomes of laparoscopic-assisted transanal total mesorectal excision (La-TaTME) of middle-low rectal carcinoma. MATERIALS AND METHODS: This retrospective research collected and analyzed the clinical data of 19 patients diagnosed with middle and low rectal carcinoma who underwent La-TaTME from August 2015 to February 2017. RESULTS: No case was converted to laparotomy. In none of the enrolled cases, did the circumferential resection margin test positive by histopathology examination...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739757/multifocal-and-multicentric-breast-carcinoma-a-significantly-more-aggressive-tumor-than-unifocal-breast-cancer
#20
Zhiqiang Lang, Yanqiu Wu, Cuiyan Li, Xinna Li, Xuan Wang, Guimei Qu
BACKGROUND/AIM: There are still many questions that surround multifocal or multicentric breast carcinoma (MMBC). The aim of this study was to analyze the clinicopathological characteristics of MMBC and provide feasible suggestions for therapy. PATIENTS AND METHODS: A total of 156 cases of MMBC in 3,597 invasive ductal breast carcinomas were collected and reviewed. Some factors related with prognosis such as tumor size, lymph node metastasis and others were assessed in each tumor focus, and mismatches among foci were recorded...
August 2017: Anticancer Research
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