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Anticancer Research

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https://www.readbyqxmd.com/read/28373480/salvage-robotic-assisted-laparoscopic-radical-prostatectomy-experience-with-14-cases
#1
Yen-Chuan Ou, Sheng-Chun Hung, Li-Hua Hwang, Chun-Kuang Yang, Siu-Wan Hung, Min-Che Tung
AIM: To report the outcomes of salvage robot-assisted radical prostatectomy (S-RaRP). PATIENTS AND METHODS: Fourteen patients underwent S-RaRP. The mean initial prostatic-specific antigen level was 14.3 ng/ml and mean Gleason score was 6.93. Initial definitive treatment was external irradiation in 11 cases, cyberknife in two, and high-intensity focused ultrasound in one. Time from definitive treatment to S-RaRP was a mean of 36.5 months. RESULTS: The mean console time was 134...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373479/eligibility-criteria-specific-to-pancreaticoduodenectomy-for-octogenarians-single-center-opinion
#2
Shunichi Shiozawa, Takebumi Usui, Kotaro Kuhara, Akira Tsuchiya, Tatsuomi Miyauchi, Teppei Kono, Yukio Shimojima, Shinichi Asaka, Kentaro Yamaguchi, Hajime Yokomizo, Takeshi Shimakawa, Kazuhiko Yoshimatsu, Takao Katsube, Yoshihiko Naritaka
BACKGROUND/AIM: Pancreaticoduodenectomy (PD) treatment outcomes in elderly patients have been reported to be acceptable, but the eligibility criteria are not clear. To elucidate the importance of PD in octogenarians in particular, we set five eligibility criteria for elderly patients based on preoperative cardiac and pulmonary function, nutritional status, daily activity status, and psychological independence status for the first time and evaluated prospectively whether the validity of patient selection was adaptable...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373478/second-primary-malignancy-in-bladder-carcinoma-a-population-based-study
#3
Amit Khanal, Nibash Budhathoki, Vijay Pal Singh, Binay K Shah
BACKGROUND: A second primary malignancy is a serious long-term complication in cancer survivors. The aim of this study was to evaluate the risk of second primary malignancies (SPM) in adult patients with bladder cancer. MATERIALS AND METHODS: We selected patients ≥18 years diagnosed with bladder cancer from National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) 13 database. We calculated the risk of second primary malignancies in the bladder cancer patients using the MP-SIR session of SEER*stat software...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373477/comprehensive-surgical-treatment-as-the-mainstay-of-management-in-retroperitoneal-sarcomas-retrospective-study-from-two-non-sarcoma-specialist-centers
#4
Athanasios Petrou, Anastasia Constantinidou, Michael Kontos, Alexandros Papalampros, Demetrios Moris, Chris Bakoyiannis, Kyriakos Neofytou, George Kourounis, Evangelos Felekouras
BACKGROUND/AIM: Complete resection, surgical expertise and individualization of patient management in comprehensive oncology centres result in better clinical outcomes in patients presenting with retroperitoneal sarcomas. PATIENTS AND METHODS: Clinical outcomes of primary and recurrent retroperitoneal sarcoma resections performed between January 2002 and December 2016 in two large surgical oncology, but non-sarcoma specialist centers, were reviewed to determine the efficacy of complete surgical resection as the principle instrument for treatment...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373476/short-and-long-term-progress-of-recurrent-laryngeal-nerve-paralysis-after-subtotal-esophagectomy
#5
Hiroki Shimizu, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Toshiyuki Kosuga, Shuhei Komatsu, Daisuke Ichikawa, Kazuma Okamoto, Eigo Otsuji
AIM: To clarify risk factors and long-term progress of postoperative recurrent laryngeal nerve paralysis (PRNP) in patients with esophageal cancer. PATIENTS AND METHODS: One hundred and twenty-five esophageal cancer patients, who underwent subtotal esophagetomy, including recurrent laryngeal nerve lymphadenectomy, were analyzed. A laryngoscopy was routinely performed to assess the motility of vocal cords. RESULTS: PRNP was detected in 79 patients and 26 (20...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373475/cancer-stem-cell-gene-variants-in-cd44-predict-outcome-in-stage-ii-and-stage-iii-colon-cancer-patients
#6
Michael Stotz, Sereina A Herzog, Martin Pichler, Maria Smolle, Jakob Riedl, Christopher Rossmann, Angelika Bezan, Herbert Stöger, Wilfried Renner, Andrea Berghold, Armin Gerger
BACKGROUND/AIM: Growing evidence suggests that human cancers are stem cell diseases and recent data support the existence of cancer stem cells (CSCs) in a variety of malignancies, including colon cancer. These CSCs were shown to be capable of initiating tumor development and progression. Several studies have suggested CD133, CD26 and CD44 as markers of tumor-initiating cells of colon cancer. The purpose of the present study was to assess the impact of single-nucleotide polymorphisms (SNPs) in stem cell-related genes on clinical outcome in a large cohort of colon cancer patients with clinical stage II and III...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373474/evaluation-of-tumor-markers-and-their-impact-on-prognosis-in-gallbladder-bile-duct-and-cholangiocellular-carcinomas-a-pilot-study
#7
Vaclav Liska, Vladislav Treska, Tomas Skalicky, Jakub Fichtl, Jan Bruha, Ondrej Vycital, Ondrej Topolcan, Richard Palek, Jachym Rosendorf, Jiri Polivka, Lubos Holubec
BACKGROUND/AIM: The behavior of tumor markers in biliary tract malignancies is not well-known and has been scarcely studied. Such markers could play important roles in diagnostic and prognostic schemes as well as in decision-making about the best treatment strategies. This study analyzed the preoperative serum levels of conventional tumor markers (AFP, CEA, CA 19-9, CA 72-4), proliferative marker thymidine kinase (TK) and cytokeratins (TPA, TPS and CYFRA 21.1) in patients with gallbladder carcinoma, bile duct carcinoma (Klatskin) and cholangiocellular carcinoma, in relation to the patient prognosis...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373473/telomere-length-in-leukocyte-dna-in-gastric-cancer-patients-and-its-association-with-clinicopathological-features-and-prognosis
#8
Tomomitsu Tahara, Sayumi Tahara, Noriyuki Horiguchi, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Hyuga Yamada, Dai Yoshida, Takafumi Ohmori, Kohei Maeda, Naruomi Komura, Hirokazu Ikuno, Yasutaka Jodai, Toshiaki Kamano, Mitsuo Nagasaka, Yoshihito Nakagawa, Tetsuya Tuskamoto, Makoto Urano, Tomoyuki Shibata, Makoto Kuroda, Naoki Ohmiya
BACKGROUND/AIM: Telomere shortening in leukocytes has been thought to be associated with reduced immune response capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. MATERIALS AND METHODS: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373472/prognostic-value-of-prepectoral-edema-in-mr-mammography
#9
Clemens G Kaiser, Michael Herold, Julia Krammer, Pascal Baltzer, Mieczyslaw Gajda, Oumar Camara, Stefan Schoenberg, Werner A Kaiser, Matthias Dietzel
BACKGROUND/AIM: Previous studies have indicated a highly significant correlation between invasive tumors and accompanying prepectoral edema (PE) in MR-mammography (MRM). The aim of the present study was to identify prognostic factors associated with PE as a diagnostic sign. MATERIALS AND METHODS: A total of 1,109 consecutive MRM exams were included in this study. Exclusion criteria were previous operation, biopsy, intervention, chemotherapy, hormone replacement therapy (HRT) or previous mastitis...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373471/continuation-of-a-levonorgestrel-intrauterine-device-during-hematopoietic-stem-cell-transplant-a-case-report
#10
Paula C Brady, Robert J Soiffer, Elizabeth S Ginsburg
BACKGROUND: During treatment of hematologic malignancies in premenopausal women, both menstrual suppression and contraception are crucial. Continuation of hormonal intrauterine devices (IUDs) - widely used and highly effective contraceptives that also decrease menstrual flow - is controversial during hematopoietic stem cell transplants (SCTs) due to infectious and vaginal bleeding concerns. CASE REPORT: A 23-year-old nulligravid female was diagnosed with acute myeloid leukemia (AML, positive for FLT3-ITD, DNMT3A and RUNX1, with normal cytogenetics)...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373470/clinical-significance-of-serum-p53-antibody-in-the-early-detection-and-poor-prognosis-of-gastric-cancer
#11
Masaki Kunizaki, Akiko Fukuda, Kouki Wakata, Tetsuro Tominaga, Takashi Nonaka, Takuro Miyazaki, Keitaro Matsumoto, Yorihisa Sumida, Shigekazu Hidaka, Toru Yasutake, Terumitsu Sawai, Ryuji Hamamoto, Atsushi Nanashima, Takeshi Nagayasu
BACKGROUND: The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS: Serum samples were obtained preoperatively from 208 patients with histologically-confirmed GC, including 126 stage I patients (60.6%). Levels of S-p53Ab were assessed by a commercial laboratory using an anti-p53 detection kit...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373469/nab-paclitaxel-and-gemcitabine-in-advanced-pancreatic-cancer-the-one-year-experience-of-the-national-cancer-institute-of-naples
#12
Alessandro Ottaiano, Monica Capozzi, Chiara DE Divitiis, Claudia VON Arx, Elena DI Girolamo, Guglielmo Nasti, Ernesta Cavalcanti, Fabiana Tatangelo, Giovanni Romano, Antonio Avallone, Salvatore Tafuto
BACKGROUND: Pancreas adenocarcinoma is the sixth cause of cancer-related death worldwide with an increasing mortality in the Western countries. Recently, the association between nab-paclitaxel (nab-P) and gemcitabine (GEM) has significantly improved progression-free and overall survival. PATIENTS AND METHODS: Patients affected by metastatic pancreas adenocarcinoma were treated at the Department of Abdominal Oncology of the National Cancer Institute of Naples from July 2015 to July 2016 with nab-P at 125 mg per square meter of body-surface area followed by GEM at 1,000 mg per square meter on days 1, 8 and 15 every 4 weeks...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373468/analysis-of-factors-affecting-short-term-results-in-elderly-patients-undergoing-elective-surgical-resection-for-stage-i-ii-colon-cancer
#13
Stefano M M Basso, Franco Lumachi, Patrizio Pianon, Giovanni Fanti, Federica Maffeis, Paolo Ubiali
AIM: The aim of this study was to analyze the influence of comorbidities and to compare the short-term results of elective surgical resection of stage I-II colon adenocarcinoma in elderly (≥65 years) versus younger patients. PATIENTS AND METHODS: Two groups of sex-matched younger and older patients were compared: Group A: N=36, median age 58 (range=43-65) years; and group B: N=67, median age 73 (range=66-86) years. RESULTS: Overall, 71 out of 103 (68...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373467/efficacy-of-single-dose-first-generation-5-ht3-receptor-antagonist-and-dexamethasone-for-preventing-nausea-and-vomiting-induced-by-low-dose-carboplatin-based-chemotherapy
#14
Daizo Kaito, Hirotoshi Iihara, Norihiko Funaguchi, Junki Endo, Fumitaka Ito, Komei Yanase, Sayaka Toyoshi, Yuka Sasaki, Chiemi Hirose, Natsumi Arai, Mika Kitahora, Yasushi Ohno, Yoshinori Itoh, Shinya Minatoguchi
BACKGROUND: Carboplatin (CBDCA) is known to exhibit a high emetic risk among moderate-emetic risk anticancer drugs, and the dose of CBDCA varies in different therapies. In concurrent chemoradiotherapy (CCRT) for non-small cell lung cancer (NSCLC), the weekly administration of CBDCA (area under the curve (AUC) 2 mg/ml/min) and paclitaxel (PTX: 40 mg/m(2)) is frequently applied as standard therapy. However, the optimal antiemetic measures in the use of such low-dose CBDCA remain unclear...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373466/a-retrospective-analysis-of-ki-67-index-and-its-prognostic-significance-in-over-800-primary-breast-cancer-cases
#15
Fabinshy Thangarajah, Insa Enninga, Wolfram Malter, Stefanie Hamacher, Birgid Markiefka, Lisa Richters, Stefan Krämer, Peter Mallmann, Verena Kirn
BACKGROUND/AIM: The Ki-67 index is chiefly important for distinguishing between luminal A and luminal B human epidermal growth factor receptor 2 (HER2neu)-negative breast cancer subtypes. However, its ability to predict response to chemotherapy is uncertain. PATIENTS AND METHODS: Patients treated for primary breast cancer at the University Hospital of Cologne were identified. Immunohistochemistry for Ki-67 detection was performed according to standard protocols...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373465/evaluation-of-prognostic-immune-signatures-in-patients-with-breast-colorectal-and-pancreatic-cancer-receiving-chemotherapy
#16
Ursula M Vogl, Leopold Öhler, Masa Rasic, Josa M Frischer, Madhura Modak, Johannes Stöckl
BACKGROUND: CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) receptor family and is dominantly expressed on immune cells and in a variety of malignant diseases. B7-H1 and B7-H3 are transmembrane proteins that are involved in suppression of the immune system. The aim of this study was to evaluate if these molecules are up-regulated in patients with cancer and change during chemotherapy. MATERIALS AND METHODS: We analyzed cluster of differentiation (CD) protein expression levels on tumor cell lines and in blood samples of 37 patients with solid tumors at baseline and during chemotherapy; we correlated the serum levels of CD proteins with survival outcome...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373464/effects-of-lidocaine-on-ht-29-and-sw480-colon-cancer-cells-in-vitro
#17
Anika C Bundscherer, Manuela Malsy, Diane I Bitzinger, Christoph H R Wiese, Michael A Gruber, Bernhard M Graf
BACKGROUND: Evidence is growing that the risk of cancer dissemination may be enhanced during the perioperative period. Whether particular anesthetic techniques influence oncological outcome is still under discussion. For pain management, lidocaine can be administered perioperatively by intravenous, intraperitoneal or epidural infusion. Here we investigated the effect of lidocaine on colon carcinoma cell lines (HT-29 and SW480) in vitro. MATERIALS AND METHODS: ELISA BrdU (Roche) for cell proliferation and FITC Annexin V detection kit (BD Pharming) for apoptosis analysis were applied...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373463/unstaged-diffuse-large-b-cell-lymphoma-in-the-united-states-predictors-and-patient-outcomes
#18
Amir Bista, Sandhya Sharma, Taufiq Rijwani, Binay K Shah
BACKGROUND: Treatment and prognosis of diffuse large B-cell lymphoma (DLBCL) depends on the stage of lymphoma. We conducted this study to examine unstaged DLBCL in the United States. MATERIALS AND METHODS: We used Surveillance Epidemiology and End Result (SEER) 18 registries to select patients with DLBCL diagnosed during January 2000 to December 2012. Limited regional distant Summary stage 2000 was used to determine stage of the disease as localized, regional, distant or unstaged...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373462/expression-of-anti-apoptotic-protein-bag3-in-human-sebaceous-gland-carcinoma-of-the-eyelid
#19
Tatsuya Yunoki, Yoshiaki Tabuchi, Atsushi Hayashi
BACKGROUND: Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), has been shown to play a role in anti-apoptosis of various malignant tumors. In this study, the expression of BAG3 was examined in human sebaceous gland carcinoma of the eyelid. MATERIALS AND METHODS: The expression of BAG3 was evaluated by immunohistochemistry of surgical samples from 5 patients with sebaceous gland carcinoma in the eyelid. RESULTS: BAG3 was positive diffusely in the cytoplasm in all patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28373461/prognostic-significance-of-bmi-1-but-not-mel-18-expression-in-pulmonary-squamous-cell-carcinoma
#20
Sosei Abe, Shin-Ichi Yamashita, S O Miyahara, Junichi Wakahara, Leona Yamamoto, Ryo Mori, Naoko Imamura, Yasuhiro Yoshida, Ryuichi Waseda, Masafumi Hiratsuka, Takeshi Shiraishi, Kazuki Nabeshima, Akinori Iwasaki
AIM: We investigated the possibility of BMI-1 and MEL-18 to predict survival in patients with pulmonary squamous cell carcinoma. MATERIALS AND METHODS: One hundred and ninety-nine patients underwent surgery in our Institute between 1995 and 2005. We used immunohistochemical (IHC) analysis to determine the expressions of BMI-1 and MEL-18 and compared them with clinicopathological factors and survival. RESULTS: Forty-one of 199 cases (21%) were BMI-1-positive...
April 2017: Anticancer Research
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