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Anticancer Research

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https://www.readbyqxmd.com/read/30194218/antimicrobial-peptides-in-gastrointestinal-diseases-1st-edition
#1
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194217/biological-inorganic-chemistry-3rd-edition
#2
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194216/book-reviews
#3
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194215/synchronous-laryngeal-squamous-cell-carcinoma-and-intrahepatic-cholangiocarcinoma-present-in-an-obese-male-with-poor-prognosis
#4
Peter Jiang, Lin Gu, Yihua Zhou, Yulin Zhao, Jinping Lai
Concurrent laryngeal squamous cell carcinoma and intrahepatic cholangiocarcinoma is rare and no prior report has been found through a PubMed search. Here we report such a case of a 51-year old obese male presenting with hoarseness and trouble swallowing for 2 to 3 months. Imaging findings of computer tomography (CT) and magnetic resonance imaging (MRI) with and without contrast were suspicious for a T3N2 supraglottic laryngeal cancer. Laryngeal biopsy showed a well differentiated squamous cell carcinoma (SCC)...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194214/impact-of-primary-tumor-localization-on-the-efficacy-of-bevacizumab-in-metastatic-colorectal-cancer
#5
COMPARATIVE STUDY
Frank Jordan, Nina Grundmann, Gerhard Schenkirsch, Bruno Märkl, Helmuth Messmann, Matthias Anthuber, Christoph Schmid, Martin Trepel
AIM: Right- and left-sided primary tumors of colorectal origin differ substantially in several aspects. Recent retrospective analyses show distinct efficacy of EGFR-epidermal growth factor receptor (EGFR)-directed therapies for left- and right-sided primary tumors. Current treatment guidelines have accommodated these findings such that for right-sided primary tumors, EGFR-directed therapy is no longer recommended. Instead, vascular endothelial growth factor (VEGF)-directed therapies are recommended frequently in first line, even in tumors with wild-type rat sarcoma (RAS) status...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194213/portal-vein-embolization-pve-versus-pve-with-haematopoietic-stem-cell-application-in-patients-with-primarily-non-resectable-colorectal-liver-metastases
#6
COMPARATIVE STUDY
Vladislav Treska, Jakub Fichtl, Jaroslav Ludvik, Jan Bruha, Vaclav Liska, Inka Treskova, Radek Kucera, Ondrej Topolcan, Daniel Lysak, Tomas Skalicky, Jiri Ferda
BACKGROUND: Portal vein embolization (PVE) and PVE with autologous mesenchymal stem cell application (PVE-MSC) increases future liver remnant volume (FLRV). The aim of this study was to compare both methods from the aspect of FLRV growth, progression of colorectal liver metastases (CLM), CLM resectability and long-term results. PATIENTS AND METHODS: Fifty-five patients with CLM and insufficient FLRV were included in the study. FLVR growth and CLM volume were evaluated using computed tomography...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194212/a-combination-of-findings-obtained-from-pre-and-postoperative-imaging-predict-recovery-of-urinary-continence-after-non-nerve-sparing-laparoscopic-radical-prostatectomy
#7
Takehisa Onishi, Sho Sekito, Takeshi Terabe, Takuji Shibahara
BACKGROUND/AIM: The aim of the study was to identify the reliable predictor for early recovery of urinary continence (UC) after non-nerve-sparing laparoscopic radical prostatectomy (NNS-LRP) according to the findings of pre- and postoperative imaging. MATERIALS AND METHODS: A retrospective analysis of 215 patients who underwent NNS-LRP was carried out. Early recovery of UC was defined as using no pads or one security pad per day within 3 months. Preoperative membranous urethral length (MUL) measured on MRI and postoperative bladder neck angle (BNA) identified by cystography were analyzed to evaluate the relationship with recovery of UC...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194211/iterative-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-recurrent-peritoneal-metastases
#8
Antonio Sommariva, Marco Tonello, Camilla Cona, Pierluigi Pilati, Carlo Riccardo Rossi
BACKGROUND: Our aim was to analyze the safety and efficacy of iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (iCRS-HIPEC) in patients with peritoneal recurrence from different tumor types. PATIENTS AND METHODS: Data on indications, intraoperative findings and postoperative outcome of all patients treated with iCRS-HIPEC at our Institution were reviewed. RESULTS: Between 2010-2018, 10 iCRS-HIPEC procedures for peritoneal recurrence in eight patients were performed...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194210/serum-asunaprevir-and-daclatasvir-concentrations-and-outcomes-in-patients-with-recurrent-hepatitis-c-who-have-undergone-living-donor-liver-transplantation
#9
Noboru Harada, Tomoharu Yoshizumi, Toru Ikegami, Shinji Itoh, Norihiro Furusho, Masaki Kato, Shinji Shimoda, Takasuke Fukuhara, Yuji Soejima, Yoshihiko Maehara
BACKGROUND/AIM: This study's aim was to investigate the safety and effectiveness of asunaprevir and daclatasvir treatment for recurrent hepatitis C virus (HCV) infection in transplant recipients. The study cohort comprised 14 transplant recipients with recurrent hepatitis C who were receiving asunaprevir and daclatasvir. PATIENTS AND METHODS: Serum concentrations of asunaprevir and daclatasvir, their therapeutic effects, trough concentrations/dose ratios of tacrolimus, and adverse effects were evaluated...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194209/the-radiological-differentiation-of-hypervascular-intrahepatic-cholangiocarcinoma-from-hepatocellular-carcinoma-with-a-focus-on-the-ct-value-on-multi-phase-enhanced-ct
#10
COMPARATIVE STUDY
Shusei Sano, Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhisa Ohgi, Takeshi Aramaki, Yasuni Nakanuma, Katsuhiko Uesaka
BACKGROUND/AIM: This study aimed to investigate whether hypervascular intrahepatic cholangiocarcinoma (HICC) can be differentiated from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Among 100 patients with intrahepatic cholangiocarcinoma, 22 patients were diagnosed with HICC based on the computed tomography (CT) value in the late arterial phase as follows: the CT value of the tumor ≥ that of the liver parenchyma. The CT values of the HICC were compared to those of HCC cases (n=120)...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194208/the-combination-of-neutrophil-to-lymphocyte-ratio-and-serum-carbohydrate-antigen-19-9-level-as-a-prognostic-indicator-in-patients-with-recurrent-pancreatic-cancer
#11
Teruhisa Sakamoto, Hiroaki Saito, E I Uchinaka, Masaki Morimoto, Masataka Amisaki, Naruo Tokuyasu, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara
BACKGROUND/AIM: We retrospectively investigated the relationship between prognosis and combined neutrophil-to-lymphocyte ratio (NLR) and serum carbohydrate antigen 19-9 (CA19-9) levels in patients with recurrent pancreatic cancer. PATIENTS AND METHODS: We enrolled 66 patients whose pancreatic cancer recurred. RESULTS: Based on ROC analysis results, the patients were divided into NLRHigh (NLR ≥1.69) or NLRLow (NLR <1.69), and into CA19-9High (CA19-9 ≥107...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194207/ttf-1-expression-predicts-the-merit-of-additional-antiangiogenic-treatment-in-non-squamous-non-small-cell-lung-cancer
#12
Akira Takeuchi, Tetsuya Oguri, Yoriko Yamashita, Kazuki Sone, Satoshi Fukuda, Osamu Takakuwa, Takehiro Uemura, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito, Akio Niimi
BACKGROUND/AIM: To investigate whether TTF-1 expression predicts a beneficial response of non-squamous non-small-cell lung cancer (NS-NSCLC) patients to bevacizumab. PATIENTS AND METHODS: We retrospectively screened 118 advanced NS-NSCLC patients who were treated with pemetrexed plus platinum derivatives alone (Bev(-)) or with bevacizumab (Bev(+)), and investigated the relationship between expression of TTF-1 and treatment outcomes. RESULTS: Among the 92 TTF-1-positive patients, clinical outcomes in the Bev(+) group were significantly better than those in the Bev(-) group (response rate, 51...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194206/recurrence-rates-and-characteristics-of-phyllodes-tumors-diagnosed-by-ultrasound-guided-vacuum-assisted-breast-biopsy-vabb
#13
Hai-Lin Park, Young Chan Pyo, Ka Young Kim, Jong Seob Park, Ji-Eun Shin, Hye-Rin Kim, Bora Yang, Ji-Young Kim, Jeong Yun Shim, Eun-Ah Shin, Song-Mi Noh
BACKGROUND/AIM: Recently, the development of ultrasonography (US)-guided vacuum-assisted breast biopsy (VABB) has enabled the excision of benign breast tumors with normal surrounding breast tissues; thus, complete excision is possible without residual tumor tissue. We sought to identify the clinicopathological characteristics and recurrence rates of benign phyllodes tumors diagnosed by US-guided VABB. PATIENTS AND METHODS: Data from 11,221 US-guided VABBs performed at the Gangnam Cha Medical Center over 12 years were analyzed...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194205/tumor-size-driven-dose-of-intraoperative-radiotherapy-for-breast-cancer-18-gy-versus-21-gy
#14
COMPARATIVE STUDY
Elisabetta Bonzano, Liliana Belgioia, Piero Fregatti, Daniele Friedman, Stefano Agostinelli, Francesca Cavagnetto, Monica Bevegni, Renzo Corvò, Marina Guenzi
AIM: To test whether a reduced total single dose of 18 Gy of intraoperative radiotherapy with electrons (IORT) may be tailored to safely treat patients in comparison with the standard dose of 21 Gy. (NCT01276938). PATIENTS AND METHODS: From October 2009 to December 2011, 199 females affected by breast cancer were treated with conservative surgery and IORT with two different exclusive doses, 18 or 21 Gy. RESULTS: The median follow-up was 91 months (16-104 months)...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194204/clinicopathological-characteristics-of-ovarian-metastasis-from-colorectal-and-pancreatobiliary-carcinomas-mimicking-primary-ovarian-mucinous-tumor
#15
Cheol Keun Park, Hyun-Soo Kim
BACKGROUND/AIM: A subset of carcinomas metastatic to the ovary can exhibit growth patterns closely resembling ovarian mucinous cystadenoma and borderline tumor. They can be misinterpreted as underlying primary ovarian mucinous tumors and can be erroneously used to suggest that the carcinomatous component arises from mucinous precursor lesions. MATERIALS AND METHODS: We investigated the clinicopathological characteristics of 11 cases of metastatic carcinoma that had metastasized from colorectal and pancreatobiliary carcinoma and mimicked primary ovarian mucinous tumors...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194203/dynamic-contrast-enhanced-magnetic-resonance-imaging-for-patients-with-breast-cancer-receiving-first-line-bevacizumab-and-paclitaxel
#16
Katsuhiko Nakatsukasa, Yoshimi Ouchi, Kouichi Sakaguchi, Mari Goto, Eiichi Konishi, Tetsuya Taguchi
BACKGROUND: Bevacizumab plus paclitaxel shows promise for metastatic disease; however, there is no predictive biomarker. Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) is widely used to evaluate the efficacy of anti-angiogenic therapies. PATIENTS AND METHODS: Patients with locally advanced/metastatic breast cancer who had not received any prior chemotherapy or hormone therapy were included. DCE-MRI was conducted at baseline and after one and two cycles of bevacizumab and paclitaxel...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194202/demographical-profile-and-spectrum-of-multiple-malignancies-in-children-and-adults-with-neurocutaneous-disorders
#17
Agata Marjanska, Agnieszka Jatczak-Gaca, Agnieszka Wojtkiewicz, Mariusz Wysocki, Jan Styczynski
BACKGROUND/AIM: Neurocutaneous disorders, also referred as phacomatoses, are congenital disorders manifesting at different ages with central nervous system and cutaneous abnormalities. Analysis of the demographic and clinical profile of patients with phacomatoses in the context of the incidence and spectrum of malignancy. MATERIALS AND METHODS: This is a retrospective analysis of 20 years of data in a single-center study in Poland. RESULTS: Phacomatoses were diagnosed in 45...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194201/primary-tumor-score-based-on-tumor-depth-and-length-predicts-prognosis-in-esophageal-squamous-cell-carcinoma
#18
COMPARATIVE STUDY
Takaaki Arigami, Yasuto Uchikado, Itaru Omoto, Ken Sasaki, Yoshiaki Kita, Tetsuhiro Owaki, Shigehiro Yanagita, Shinichiro Mori, Hiroshi Kurahara, Hiroshi Okumura, Kosei Maemura, Shoji Natsugoe
AIM: To examine the depth of tumor invasion and tumor length and assess the clinical impact of the primary tumor score (PTS), based on a combination of tumor invasion and tumor length, in patients with esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: A total of 237 patients with ESCC were classified into three PTS groups based on cut-off values for deeper tumor invasion (pT2-T4) and greater tumor length (≥44 mm). A PTS of 2 indicated the presence of both of these abnormalities, 1 indicated one of these abnormalities, and 0 indicated neither abnormality...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194200/prediction-of-response-to-stereotactic-radiosurgery-for-brain-metastases-using-convolutional-neural-networks
#19
Yu Jin Cha, Won Il Jang, Mi-Sook Kim, Hyung Jun Yoo, Eun Kyung Paik, Hee Kyung Jeong, Sang-Min Youn
BACKGROUND: It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response of BM to radiosurgery. MATERIALS AND METHODS: Tumor images of 110 BM post stereotactic-radiosurgery (SRS) (within 3 months) were assessed (Response Evaluation Criteria in Solid Tumor, version 1...
September 2018: Anticancer Research
https://www.readbyqxmd.com/read/30194199/outcome-of-patients-with-metastatic-castration-resistant-prostate-cancer-after-psa-progression-with-abiraterone-acetate
#20
Sheng-Chun Hung, Shian-Shiang Wang, Jian-Ri Li, Mei-Chih Chen, Cheng-Kuang Yang, Chuan-Shu Chen, Hao-Chung Ho, Kun-Yuan Chiu, Chen-Li Cheng, Chao-Hsiang Chang, Yen-Chuan Ou
BACKGROUND/AIM: The main purpose of this study was to evaluate the outcome of patients with prostate-specific antigen (PSA) progression after abiraterone acetate (AA) treatment for metastatic castration-resistant prostate cancer (mCRPC). PATIENTS AND METHODS: Between 2012 and 2017, 83 patients with clinically-confirmed mCRPC previously treated with docetaxel with/without cabazitaxel followed by AA were included in this retrospective study. All patients received 1,000 mg AA with 5 or 10 mg prednisolone...
September 2018: Anticancer Research
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