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https://www.readbyqxmd.com/read/30006473/controlling-the-regioselectivity-and-stereospecificity-of-fad-dependent-polyamine-oxidases-with-the-use-of-amine-attached-guide-molecules-as-conformational-modulators
#1
Tuomo A Keinänen, Nikolay Grigorenko, Alex R Khomutov, Qingqiu Huang, Anne Uimari, Leena Alhonen, Mervi T Hyvönen, Jouko Vepsäläinen
Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO), human spermine oxidase (SMOX) and yeast polyamine oxidase (Fms1) we demonstrate that these fundamental properties of the enzymes may be regulated using simple guide molecules, being either covalently attached to polyamines, or used as a supplement to the substrate mixtures. APAO, which naturally metabolize achiral N 1 -acetylated polyamines, displays aldehyde-controllable stereospecificity with chiral 1-methylated polyamines, like (R)- and (S)- 1-methylspermidine (1-MeSpd)...
July 13, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29976775/comprehensive-assessment-for-mirna-polymorphisms-in-hepatocellular-cancer-risk-a-systematic-review-and-meta-analysis
#2
Ben-Gang Wang, Li-Yue Jiang, Qian Xu
MiRNA polymorphisms had potential to be biomarkers for hepatocellular cancer (HCC) susceptibility. Recently, miRNA SNPs were reported to be associated with hepatocellular cancer risk, but the results were inconsistent. We performed a systematic review with a meta-analysis for the association of miRNA SNPs with HCC risk. 37 studies were included with a total of 11821 HCC patients and 15359 controls in this meta-analysis. We found hsa-mir-146a rs2910164 was associated with a decreased hepatocellular cancer risk in the recessive model ( P = 0...
July 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29976774/a-highly-significant-association-between-cathepsin-s-gene-polymorphisms-rs12068264-and-chronic-obstructive-pulmonary-disease-susceptibility-in-han-chinese-population
#3
Sheng-Lan Gao, Ya-Hong Wang, Chun-Yan Li, La-Wei Yang, Bao-An Zou, Zu-Guang Chen, Wei-Min Yao, Ze-Qing Song, Jun-Fen Cheng, Zi-Ying Lin, Gang Liu
Cathepsin S (CTSS) and Sirtuin-1 (SIRT1) played crucial roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the associations between the polymorphisms of CTSS as well as SIRT1 and COPD in Asian population remain elusive. In this study, one SNP in rs12068264 was discovered (in 385 individuals) to be associated with the susceptibility of COPD in a Chinese Han population. The genotyping was performed using improved multiplex ligase detection reaction (iMLDR) technique. Subjects with T allele of rs12068264 in CTSS gene had an increased risk of COPD (T vs C: OR=1...
July 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29976773/induced-pluripotent-stem-cell-derived-endothelial-cells-promote-angiogenesis-and-accelerate-wound-closure-in-a-murine-excisional-wound-healing-model
#4
Zoe E Clayton, Richard P Tan, Maria M Miravet, Katarina Lennartsson, John P Cooke, Christina A Bursill, Steven G Wise, Sanjay Patel
Chronic wounds are a major complication in patients with cardiovascular diseases. Cell therapies have shown potential to stimulate wound healing, but clinical trials using adult stem cells have been tempered by limited numbers of cells and invasive procurement procedures. Induced pluripotent stem cells (IPSCs) have several advantages of other cell types, for example they can be generated in abundance from patients' somatic cells (autologous) or those from a matched donor. IPSCs can be efficiently differentiated to functional endothelial cells (IPSC-ECs)...
July 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29967295/apol1-risk-variants-cause-podocytes-injury-through-enhancing-endoplasmic-reticulum-stress
#5
Hongxiu Wen, Vinod Kumar, Xiqian Lan, Seyedeh Shadafarin Marashi Shoshtari, Judith M Eng, Xiaogang Zhou, Fang Wang, Haichao Wang, Karl Skorecki, Guolan Xing, Guisheng Wu, Huairong Luo, Ashwani Malhotra, Pravin C Singhal
Two coding sequence variants (G1 and G2) of APOL1 gene have been implicated as a higher risk factor for chronic kidney diseases (CKD) in African Americans when compared to European Americans. Previous studies have suggested that the APOL1 G1 and G2 variant proteins are more toxic to kidney cells than the wild type APOL1 G0, but the underlying mechanisms are poorly understood. To determine whether endoplasmic reticulum (ER) stress contributes to podocyte toxicity, we generated human podocytes (HPs) that stably overexpressed APOL1G0, G1, or G2 (Vec/HPs, G0/HPs, G1/HPs, and G2/HPs)...
July 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29967294/tug1-promotes-prostate-cancer-progression-by-acting-as-a-cerna-of-mir-26a
#6
Bin Yang, Xiaodi Tang, Zhixin Wang, Daju Sun, Xin Wei, Youpeng Ding
PURPOSE: Previous studies have demonstrated that taurine-upregulated gene 1 (TUG1) was aberrantly expressed and involved in multiple types of cancer, however, the expression profile and potential role of TUG1 in prostate cancer (PCa) remains unclear. The aim of the present study was to evaluate the expression and function of TUG1 in PCa. METHODS: In the present study, we analyzed TUG1 expression levels of PCa patients in tumor and adjacent normal tissue by real-time quantitative PCR. Knockdown of TUG1 by RNA interference was performed to explore its roles in cell proliferation, migration, and invasion...
July 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29967293/umbelliferone-alleviates-hepatic-injury-in-diabetic-db-db-mice-via-inhibiting-inflammatory-response-and-activating-nrf2-mediated-antioxidant
#7
Jiangning Yin, Hanqing Wang, Guoyuan Lu
The current study was designed to investigate the protective effect and possible mechanisms of umbelliferone (Umb) on liver injury in diabetic C57BL/KsJ-db/db mice. Mice were divided into five groups: wide type mice group (WY), C57BL/KsJ-db/db (dbdb) mice group, C57BL/KsJ-db/db mice + Metformin (100 mg/kg) group, C57BL/KsJ-db/db mice + Umb (20, 40 mg/kg) group. Blood glucose regulation was assessed by an oral glucose tolerance test (OGTT). At 28 days after drug administration, blood samples were obtained for the analysis of lipids and enzymes related to hepatic function, including alanine aminotransferase (ALT), aspartate aminotransaminase (AST) and total cholesterol (TC) and triglyceride (TG)...
July 2, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29961674/the-diagnostic-values-of-circulating-micrornas-for-hypertension-and-bioinformatic-analysis
#8
Xiaoyi Zhang, Xiaoyan Wang, Jian Wu, Juan Peng, Xin Deng, Yi Shen, Chunjie Yang, Jie Yuan, Yun-Zeng Zou
Background: Few studies have compared the performances of those reported microRNAs (miRNAs) as biomarkers for hypertension in a same cohort, we aimed to comprehensively examine the performances of those reported miRNAs as biomarkers for hypertension and identify the genes and pathways targeted by these miRNAs. Method: Serums samples were collected from patients hospitalized for hypertension in Zhongshan Hospital. Gene expressions of 25 microRNAs were compared between hypertension and normal groups. ROC curves were used to evaluate the accuracy of those miRNAs as biomarkers for hypertension...
July 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29961673/atherosclerosis-in-subjects-newly-diagnosed-with-human-immunodeficiency-virus-infection
#9
Tatiana V Kirichenko, Veronika A Myasoedova, Tatiana E Shimonova, Alexandra A Melnichenko, Dmitri Sviridov, Igor A Sobenin, Alexey I Mazus, Alexander N Orekhov, Michael Ilya Bukrinsky
HIV infection is associated with increased risk of cardio-vascular disease (CVD), even in patients successfully treated with combination anti-retroviral therapy (cART). However, relationship between HIV, cART and pathogenesis of CVD remains controversial. In this study, we evaluated carotid intima media thickness (CIMT), a surrogate marker of atherosclerosis, in HIV-infected subjects receiving or not cART. 109 newly diagnosed HIV-infected subjects and 109 uninfected age-matched controls (all males) without history of CVD, hypertension or diabetes were recruited into this study...
July 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29961672/mir-15b-reduces-amyloid-%C3%AE-accumulation-in-sh-sy5y-cell-line-through-targeting-nf-%C3%AE%C2%BAb-signaling-and-bace1
#10
Juan Li, Haitao Wang
Background: Alzheimer's disease (AD) is the multifactorial neurodegenerative disorder causing progressive memory loss and cognitive impairment. The aberrant accumulation of Amyloid-β (Aβ) and neuroinflammation are two major events in AD. BACE1 is required for the cleavage of amyloid precursor protein (APP) to generate Aβ, which stimulates the nuclear transcription factor κB (NF-κB) signaling, leading to the secretion of inflammatory cytokines. And NF-κB can up-regulate the expression of BACE1. microRNAs (miRNAs) are small non-coding RNAs that regulate gene transcription...
July 1, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29950302/detoxication-mechanisms-of-radix-tripterygium-wilfordii-via-compatibility-with-herba-lysimachia-christinae-in-s180-bearing-mice-by-involving-nrf2
#11
Jun-Ming Wang, Hong Cai, Jin-Hua Li, Rong-Xing Chen, Yue-Yue Zhang, Jin-Yang Li, Ning-Ning Ding, Chen Liu, Ying Cui
The combined administration between Radix Tripterygium wilfordii Hook F (LGT) and Herba Lysimachia christinae Hance (JQC) belongs to mutual detoxication compatibility of seven emotions in traditional Chinese medicine (TCM) theory. However, until now, the compatibility detoxication mechanisms remain unknown. This study was undertaken to observe detoxication mechanisms of LGT through compatibility with JQC in tumor-bearing mice by involving NF-E2-related factor 2 (Nrf2)-mediated antioxidant defenses. In addition, influence of compatibility on antitumor activity was also investigated here...
June 27, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29945927/a-paternal-methyl-donor-depleted-diet-leads-to-increased-anxiety-and-depression-like-behavior-in-adult-rat-offspring
#12
Chelsea R McCoy, Nateka L Jackson, Rachel L Brewer, Mohamad M Moughnyeh, Daniel L Smith, Sarah M Clinton
Epigenetic mechanisms such as DNA methylation elicit lasting changes in gene expression and likely mediate gene x environment interactions that shape brain development, behavior and emotional health. Myriad environmental factors influence DNA methylation, including methyl donor content in the paternal diet, could influence methylation in offspring via changes in the paternal germ line. The present study examines the effects of paternal methyl donor dietary deficiency on offspring's emotional behaviors, including anxiety, social interaction, and depression-like behavior...
June 26, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29945926/anti-cancer-effect-of-histone-deacetylase-inhibitor-scriptaid-as-a-single-agent-on-hepatocellular-carcinoma
#13
Linlin Liu, Xiaoyang Sun, Yu Xie, Yinping Zhuang, Ruosi Yao, Kai Xu
Recurrence is one of the major causes of poor prognosis for patients with hepatocellular carcinoma (HCC), and drug resistance is closely associated with disease recurrence. Histone deacetylase (HDAC) inhibitor scriptaid functions as an anti-cancer agent in many different types of tumors, but its possible roles in HCC progression have not been explored to date. Herein, we show that HDAC inhibitor scriptaid decreases HCC cell proliferation and induces cell cycle G2/M phase arrest in a dose-dependent manner. Furthermore, scriptaid triggered HCC cell death via transcriptional activation of p21 and subsequent elevated global H3Ac levels...
June 26, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29934362/role-of-rnf20-in-cancer-development-and-progression-a-comprehensive-review
#14
Gautam Sethi, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar
Evolving strategies to counter cancer initiation and progression rely on the identification of novel therapeutic targets that exploit the aberrant genetic changes driving oncogenesis. Several chromatin associated enzymes have been shown to influence post-translational modification on DNA, histones, and non-histone proteins. Any deregulation of this core group of enzymes often leads to cancer development. Ubiquitylation of histone H2B in mammalian cells was identified over three decades ago. An exciting really interesting new gene (RING) family of E3 ubiquitin ligases, known as RNF20 and RNF40, monoubiquitinates histone H2A at K119 or H2B at K120 and is known to function in transcription elongation, DNA double strand break repair processes, maintenance of chromatin differentiation, and exerting tumor suppressor activity...
June 22, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29934361/fibroblasts-from-pboo-promote-tumorigenesis-by-secreting-tgfbeta1-to-induce-emt-in-bladder-urothelial-carcinoma-cells
#15
Xiongbing Lu, Lingxing Duan, Jian Zhang, Zhihua Zeng, Renrui Kuang
Urinary bladder cancer (UBC) is one of the most common malignancies worldwide. UBC patients at muscle invasive stage have poor clinical outcome, due to high propensity for metastasis. Non-tumor activated fibroblasts, named α-SMA+Fs, is similar to carcinoma-associated fibroblasts (CAFs) which could express α-SMA. However, whether α-SMA+Fs patients could induce UBC cell invasion is unclear. Herein, we found that characterization of primary α-SMA+Fs separated from PBOO (partial bladder outlet obstruction) rats was fell in between normal fibroblasts (α-SMA-Fs) and CAFs...
June 22, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29921579/fate-of-uptaken-host-proteins-in-taenia-solium-and-taenia-crassiceps-cysticerci
#16
Jeanette Flores-Bautista, José Navarrete-Perea, Gladis Fragoso, Ana Flisser, Xavier Soberón, Juan P Laclette
During the study of host-parasite relationships in Taeniid parasite diseases, including cysticercosis and hydatidosis, reports have described the presence of host proteins in the cyst fluid and tissue of metacestodes. However, the fate or role of host elements inside the parasite remains barely explored. After the publication of genomes of four cestode species, it became clear that these organisms possess a limited biosynthetic capability. The initial goal of this study was to determine if uptaken host proteins could be a source of essential amino acids for cysticerci...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29921578/the-rs3850641-polymorphism-of-the-tnfsf4-gene-increases-the-risk-of-myocardial-infarction-in-a-chinese-han-population
#17
Changqing Lu, Helei Jia, Aiguo Xu
Tumor necrosis factor superfamily member 4 (TNFSF4), also known as Ox40 ligand (Ox40l), plays an important role in atherosclerosis development. Several studies reported the association between the rs3850641 polymorphism of the TNFSF4 gene and the risk of myocardial infarction (MI). However, the results are inconsistent. In order to explore the relationship between the rs3850641 polymorphism of the TNFSF4 gene and MI, we conducted a case-control study including 454 cases and 512 controls in a Chinese Han population...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29921577/resveratrol-linoleate-protects-from-exacerbated-endothelial-permeability-via-a-drastic-inhibition-of-the-mmp-9-activity
#18
A Shamseddin, C Crauste, E Durand, P Villeneuve, G Dubois, T Pavlickova, T Durand, J Vercauteren, F Veas
Gelatinolytic matrix metalloproteinases (MMP-2, -9) play a critical role not only in mammal's physiologybut also during inflammation and healing processes. The natural stilbenoid, resveratrol (RES), exhibitspotent antioxidant effects, in a hormetic mode of action,and is known to inhibit MMP-9. However, RES administration exhibits major issues, including poor bioavailability and water solubility, hampering its potential therapeutic effect in vivo In this study, we synthesized and evaluated five novel RES-lipid conjugates to increase their cell membrane penetration and improve their bioavailability...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29921576/prolactin-as-immune-cell-regulator-in-toxocara-canis-somatic-larvae-chronic-infection
#19
Victor Hugo Del Rio-Araiza, Karen Elizabeth Nava-Castro, Fernando Alba-Hurtado, Andrés Quintanar-Stephano, Hugo Aguilar-Díaz, Marco Antonio Muñoz-Guzmán, Pedro Ostoa-Saloma, Maria Dolores Ponce-Regalado, Jorge Morales-Montor
Toxocariasis is a zoonotic disease produced by ingestion of larval Toxocara spp. eggs. Prolactin has been considered to have an important role in Toxocara canis infection. Recent evidence has found that prolactin directly can increase parasite growth and differentiation of T. canis The present study, evaluated the effect of high prolactin levels on the immune system's response and parasites clearance in chronic infection. Our results showed that hiperprolactinemia did not affected the number of larvae recovered from several tissues in rats...
June 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29921575/shen-shuai-ning-granule-decreased-serum-concentrations-of-indoxyl-sulfate-in-uremic-patients-undergoing-peritoneal-dialysis
#20
Xujiao Chen, Shouhong Gao, Mengna Ruan, Sixiu Chen, Jing Xu, Xiaohong Xing, Xiaohong Pan, Changlin Mei, Zhiguo Mao
Background Clearance of protein-bound uremic toxins (PBUTs) by dialysis is a challenge in the treatment of uremic patients. Shen-Shuai-Ning(SSN), a traditional Chinese medicine formulation, has been used commonly in China to retard kidney disease progression and decrease uremic toxins in chronic kidney disease patients, but the effects of SSN on serum PBUTs in dialysis patients were not investigated. Methods We conducted a randomized controlled trial in patients on peritoneal dialysis (PD) at dialysis center of Changzheng Hospital to evaluate the effects of SSN on serum PBUTs...
June 19, 2018: Bioscience Reports
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