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https://www.readbyqxmd.com/read/29339422/the-role-of-angiopoietin-like-protein-4-in-phenylephrine-induced-cardiomyocyte-hypertrophy
#1
Yu Sun, Yi Li, Chen Liu, Ruicong Xue, Bin Dong, Huiling Huang, Longyun Peng, Jun Liu, Yugang Dong
Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional secreted protein that can be induced by fasting, hypoxia and glucocorticoids. ANGPTL4 has been associated with a variety of diseases, however, the role of ANGPTL4 in cardiac hypertrophy remains poorly understood. In our study, we aimed to explore the effect of ANGPTL4 on phenylephrine (PE)-induced cardiomyocyte hypertrophy. Our results showed that knockdown of ANGPTL4 expression significantly exacerbated cardiomyocyte hypertrophy, as demonstrated by increased hypertrophic marker expression, including ANP and cell surface area...
January 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29339421/hif1a-rs10873142-polymorphism-is-associated-with-risk-of-chronic-obstructive-pulmonary-disease-in-a-chinese-han-population-a-case-control-study
#2
Licheng Wang, Yaliang Tang, Ye Chen
Chronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow. Recently, variants in the hypoxia-inducible factor 1α ( HIF1A ) gene were found to be associated with COPD risk. This study aimed to identify whether rs10873142 polymorphism (an intronic polymorphism) in HIF1A gene was related to COPD in a Chinese population. We genotyped HIF1A gene rs10873142 polymorphism in a case-control study with 235 COPD cases and 548 controls in a Chinese Han population...
January 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29339420/linc00673-rs11655237-c-t-confers-neuroblastoma-susceptibility-in-chinese-population
#3
Zhuorong Zhang, Yitian Chang, Wei Jia, Jiao Zhang, Ruizhong Zhang, Jinhong Zhu, Tianyou Yang, Huimin Xia, Yan Zou, Jing He
Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender- and ethnic-matched healthy controls...
January 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29339419/linc00152-down-regulated-mir-193a-3p-to-enhance-mcl1-expression-and-promote-gastric-cancer-cells-proliferation
#4
Yong Huang, Hui Luo, Fang Li, Yun'e Yang, Guangsheng Ou, Xiaolong Ye, Nianchu Li
The present work aimed to probe into the effect of long non-coding RNA (lncRNA) LINC00152 on gastric cancer (GC) cells proliferation by regulating miR-193a-3p and its target gene MCL1 Transfected si-LINC00152 was used to down-regulate LINC00152, and cells proliferation was measured by the CCK-8 assay. Cell apoptosis and cell cycle were analyzed by flow cytometry. Besides, we also detected the potential functional effects of differential expression of LINC00152 in vivo using nude mouse xenograft model. We overexpressed and down-expressed miR-193a-3p to study the in vitro effect of miR-193a-3p on GC cells proliferation and vitality...
January 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29335299/hotair-contributes-to-cell-proliferation-and-metastasis-of-cervical-cancer-via-targeting-mir-23b-mapk1-axis
#5
Qin Li, Yanhong Feng, Xu Chao, Shuai Shi, Man Liang, Yumei Qiao, Bin Wang, Pin Wang, Zhenning Zhu
The long non-coding RNA HOX transcript antisense RNA (HOTAIR) has been found overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well-known, evidence suggests that microRNA23b (miR23b) might be involved in this event. In the present study, the expressions of HOTAIR and miR23b were detected by real-time PCR in 33 paired cervical cancer tissue samples and cervical cell lines. The effects of HOTAIR on the expressions of miR23b and mitogen-activated protein kinase 1 (MAPK1) were studied by overexpression and RNA interference approaches...
January 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29335298/crystal-structure-of-ispf-from-bacillus-subtilis-and-absence-of-protein-complex-assembly-among-ispd-ispe-ispf-enzymes-in-the-mep-pathway
#6
Zhongchuan Liu, Yun Jin, Weifeng Liu, Yong Tao, Ganggang Wang
2-C-methyl-d-erythritol 2, 4-cyclodiphosphate synthase (IspF) is a key enzyme in the 2-C-Methyl-d-erythritol-4-phosphate (MEP) pathway of isoprenoid biosynthesis. This enzyme catalyzes the 4-diphosphocytidyl-2-C-methyl-d-erythritol 2-phosphate (CDPME2P) to 2-C-methyl-d-erythritol 2, 4-cyclodiphosphate (MEcDP) with concomitant release of cytidine 5'-diphospate (cytosine monophosphate) (CMP). Bacillus subtilis is a potential host cell for the production of isoprenoids, but few studies are performed on the key enzymes of MEP pathway in B...
January 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29330224/vitamin-d-ameliorates-impaired-wound-healing-in-streptozotocin-induced-diabetic-mice-by-suppressing-nf-%C3%AE%C2%BAb-mediated-inflammatory-genes-expression
#7
Yifeng Yuan, Sushant K Das, MaoQuan Li
[Background] : Diabetic wounds are characterized by delayed wound healing due to persistent inflammation and excessive production of reactive oxygen species. Vitamin D, which is well acknowledged as enhanced intestinal calcium absorption and increase in plasma calcium level, has recently been shown to display beneficial effects in various vascular diseases by promoting angiogenesis and inhibiting inflammatory responses. However the role of Vitamin Din diabetic wound healing is still unclear. [Materials and Methods] : In the present study, we investigated the role of Vitamin D in cutaneous wound healing in streptozotocin (STZ) induced diabetic mice...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29330223/the-anti-oxidant-xanthorrhizol-prevents-amyloid-%C3%AE-induced-oxidative-modification-and-inactivation-of-neprilysin
#8
Chol Seung Lim, Jung-Soo Han
Activity of neprilysin (NEP), the major protease which cleaves β-amyloid (Aβ), is reportedly reduced in the brains of patients with Alzheimer's disease (AD). Accumulation of Aβ generates reactive oxygen species (ROS) such as 4-hydroxy nonenal (HNE), and then reduces activities of Aβ-degrading enzymes including NEP. Xanthorrhizol (Xan), a natural sesquiterpenoid, has been reported to possess anti-oxidant and anti-inflammatory properties. The present study examined the effects of Xan on HNE- or oligomeric Aβ42-induced oxidative modification of NEP protein...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29330222/increased-sympathovagal-imbalance-evaluated-by-heart-rate-variability-is-associated-with-decreased-cardiac-t2-and-lv-function-in-transfusion-dependent-thalassemia-patients
#9
Sintip Pattanakuhar, Arintaya Phrommintikul, Adisak Tantiworawit, Sasikarn Konginn, Somdet Srichairattanakool, Siriporn C Chattipakorn, Nipon Chattipakorn
Early detection of iron overload cardiomyopathy is an important strategy in decreasing the mortality rate of patients with transfusion dependent thalassemia (TDT).  Although cardiac magnetic resonance (CMR) T2* is effective in detecting cardiac iron deposition, it is costly and not generally available.  We investigated whether heart rate variability (HRV) can be used as a screening method of iron overload cardiomyopathy in TDT patients.  HRV, evaluated by 24-hour Holter monitoring, non-transferrin bound iron (NTBI), serum ferritin, left ventricular ejection fraction (LVEF), and CMR-T2* were determined...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29326302/role-of-clc-k-and-barttin-in-low-potassium-induced-sodium-chloride-cotransporter-activation-and-hypertension-in-mouse-kidney
#10
Naohiro Nomura, Wakana Shoda, Yuanlong Wang, Shintaro Mandai, Taisuke Furusho, Daiei Takahashi, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
The sodium-chloride cotransporter (NCC) has been identified as a key molecule regulating potassium balance. The mechanisms of NCC regulation during low extracellular potassium concentrations have been studied in vitro. These studies have shown that hyperpolarization increased chloride efflux, leading to the activation of chloride-sensitive WNK kinases and their downstream molecules, including STE20/SPS1-related proline/alanine-rich kinase (SPAK) and NCC. However, this mechanism was not studied in vivo Previously, we developed the barttin hypomorphic mouse ( Bsndneo/neo mice), expressing very low levels of barttin and ClC-K channels, because barttin is an essential ß-subunit of ClC-K...
January 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29326301/prognostic-roles-of-signal-transducers-activators-of-transcription-family-in-human-breast-cancer
#11
Shuntao Wang, Lili Yu, Wei Shi, Xueqin Li, Lixiu Yu
Signal transducer and activator of transcription (STAT) family are critical transcription factors, which have been proved as prognostic predictors for a number of cancers. However, the prognostic roles of STAT family in breast cancer patients remain in dispute. In this study, we mined the 'Kaplan-Meier plotter' (KM plotter) online database to explore the prognostic roles of STAT family mRNA expression in breast cancer including overall survival (OS), progression-free survival (PFS), as well as post-progression survival (PPS)...
January 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29301870/lncrna-dancr%C3%A2-functions-as-a-competing-endogenous-rna-to-regulate-rab1a%C3%A2-expression-by-sponging%C3%A2-mir-634%C3%A2-in-glioma
#12
Dawei Xu, Jian Yu, Guojun Gao, Guangjian Lu, Yi Zhang, Pengju Ma
Long non-coding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) play important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in glioma tissues and cell lines using qRT-PCR and further defined the biological functions. Furthermore, we used luciferase reporter assay, western blot, and RNA immunoprecipitation (RIP) to explore the underlying mechanism...
January 4, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29301869/astragaloside-iv-inhibits-ventricular-remodeling-and-improves-fatty-acid-utilization-in-rats-with-chronic-heart-failure
#13
Bin Tang, Jin-Guo Zhang, Hong-Yong Tan, Xi-Qing Wei
Chronic heart failure (CHF) is the end-stage of many cardiovascular diseases and severely affects the patients' lifespan. Inhibiting ventricular remodeling is thus a primary treatment target for CHF patients. Astragaloside IV (AS-IV) can improve cardiac function and protect myocardial cells. The study aims to investigate the effects of AS-IV on ventricular remodeling and explore its role in regulating energy metabolism using a rat CHF model. Sprague Dawley rats were divided into 5 groups (N=20 per group):  CHF + benazepril hydrochloride, CHF + low-dose (30 mg...
January 4, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29301868/identification%C3%A2-and%C3%A2-characterization%C3%A2-of%C3%A2-two%C3%A2-types%C3%A2-of%C3%A2-amino%C3%A2-acid-regulated%C3%A2-acetyltransferases%C3%A2-in%C3%A2-actinobacteria-%C3%A2-comments%C3%A2-regarding%C3%A2-the%C3%A2-bioscience%C3%A2-reports-by-lu
#14
https://www.readbyqxmd.com/read/29298881/multiple-intracellular-signaling-pathways-orchestrate-adipocytic-differentiation-of-human-bone-marrow-stromal-stem-cells
#15
Dalia Ali, Sarah Abuelreich, Nora Alkeraishan, Najla Bin Shwish, Rimi Hamam, Moustapha Kassem, Musaad Alfayez, Abdullah Aldahmash, Nehad M Alajez
Bone marrow adipocyte formation plays a role in bone homeostasis and whole body energy metabolism. However, the transcriptional landscape and signaling pathways associated with adipocyte lineage commitment and maturation are not fully delineated. Thus, we performed global gene expression profiling during adipocyte differentiation of human bone marrow stromal (mesenchymal) stem cells (hMSCs) and identified 2,589 upregulated and 2,583 down regulated mRNA transcripts. Pathway analysis on the upregulated gene list untraveled enrichment in multiple signaling pathways including insulin receptor signaling, focal Adhesion, metapathway  biotransformation, a number of metabolic pathways e...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29298880/the-catalytic-inactivation-of-the-n-half-of-human-hexokinase-2-and-structural-and-biochemical-characterization-of-its-mitochondrial-conformation
#16
Mir Hussain Nawaz, Juliana C Ferreira, Lyudmila Nedyalkova, Haizhong Zhu, César Carrasco-López, Serdal Kirmizialtin, Wael M Rabeh
The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the "Warburg effect". The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in all aggressive tumors and predominantly found on the mitochondria, where interactions through its N-terminus initiates and maintains tumorigenesis. Here, we report the structure of HK2 in complex with glucose and glucose 6-phosphate...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29298879/combined-drug-therapeutic-strategies-for-the-effective-treatment-of-triple-negative-breast-cancer
#17
Naveen Kr Chalakur-Ramireddy, Suresh B Pakala
Triple negative breast cancer (TNBC) is a subtype of breast cancer with an aggressive phenotype which shows high metastatic capability and poor prognosis. Owing to its intrinsic properties like heterogeneity, lack of hormonal receptors, and aggressive phenotype leaves chemotherapy as a mainstay for the treatment of TNBC. Various studies have demonstrated that chemotherapy alone or therapeutic drugs targeting TNBC pathways, epigenetic mechanisms and immunotherapy alone have not shown significant improvement in TNBC patients...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29298878/ager-promotes-proliferation-and-migration-in-cervical-cancer
#18
Xuejie Zhu, Lulu Zhou, Ruyi Li, Qi Shen, Huihui Cheng, Zongji Shen, Haiyan Zhu
Advanced Glycation End-products Specific receptor for (AGER) is an oncogenic trans-membranous receptor up-regulated in various human cancers. We have previously reported that AGER was over-expressed in squamous cervical cancer. However, mechanisms of AGER involved in progression of cervical cancer are unknown. In this study, we investigated the effects of AGER on biological behavior, including proliferation, apoptosis, and migration using multiple biological approaches. AGER protein primarily localized in the cytoplasm and cytomembrane of cervical squamous cancer cells...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29298877/molecular-basis-for-potentiation-of-cx36-gap-junction-channel-conductance-by-n-alcohols-and-general-anesthetics
#19
Vytautas Raškevičius, Vaidas Jotautis, Lina Rimkutė, Alina Marandykina, Mintautė Kazokaitė, Visvaldas Kairys, Vytenis Arvydas Skeberdis
In our recent study, we have demonstrated that short carbon chain n -alcohols (up to octanol) stimulated while long carbon chain n -alcohols inhibited the conductance of connexin 36 (Cx36) gap junction (GJ) channels. In contrast, GJ channels composed of other types of Cxs all were inhibited by n -alcohols independently on their carbon chain length. To identify the putative structural domains of Cx36, responsible for the dual effect of n -alcohols, we performed structural modeling of Cx36 protein docking with hexanol and isoflurane that stimulated as well as nonanol and carbenoxolone that inhibited the conductance of Cx36 GJs and revealed their multiple common docking sites and a single pocket accessible only to hexanol and isoflurane...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29298876/correlation-between-mbl-cd14-and-tnf-%C3%AE-gene-polymorphisms-with-susceptibility-to-spinal-tuberculosis-in-chinese-population
#20
Mingfeng Zheng, Shiyuan Shi, Wei Wei, Qi Zheng, Yifan Wang, Xiaozhang Ying, Di Lu
Objective: This study investigated the clinical significances of mannose-binding lectin2(MBL2), cluster of differentiation 14(CD14) and tumor necrosis factor- α (TNF-α) gene polymorphisms in spinal tuberculosis(TB) patients in Chinese population. Methods: A total of 240 patients with spinal TB were enrolled in this study from May 2013 to August 2016 at Hangzhou Red Cross Hospital. 150 age- and sex-matched healthy subjectes were enrolled as controls. The genomic DNA was extracted from peripheral blood of all subjects, and the MBL2, CD14 and TNF-α gene polymorphisms were detected by direct DNA sequencing...
January 3, 2018: Bioscience Reports
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