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Bioscience Reports

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https://www.readbyqxmd.com/read/28539332/identification-and-characterization-of-two-types-of-amino-acid-regulated-acetyltransferases-in-actinobacteria
#1
Yu-Xing Lu, Xin-Xin Liu, Wei-Bin Liu, Bang-Ce Ye
One hundred and fifty GCN5-like acetyltransferases with amino acid-binding (ACT)-GCN5-related N- acetyltransferase (GNAT) domain organization have been identified in actinobacteria. The ACT domain is fused to the GNAT domain, conferring amino acid-induced allosteric regulation to these protein acetyltransferases (AAPatA). Members of the AAPatA family share similar secondary structure and are divided into two groups based on the allosteric ligands of the ACT domain: the asparagine-activated PatA and the cysteine-activated PatA...
May 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28539331/overexpression-oflongintergenicnoncoding-rna-linc00312inhibits-the-invasion-and-migration-of-thyroid-cancer-cells-by-down-regulating-microrna-197-3p
#2
Kai Liu, Wen Huang, Dan-Qing Yan, Qing Luo, Xiang Min
The study evaluated the ability of LINC00312 to influence the proliferation, invasion and migration of thyroid cancer (TC) cells by regulating microRNA-197-3p (miRNA-197-3p). TC  tissues and adjacent normal tissues were collected from 211 TC patients. K1 (papillary TC), SW579 (squamous TC) and 8505C (anaplastic TC) cell lines were assigned into a blank, negative control (NC), LINC00312 overexpression, miR-197-3p inhibitors and LINC00312 overexpression + miR-197-3p mimics group. The expression of LINC00312, miR-197-3p and p120 was measured using quantitative real time polymerase chain reaction (qRT-PCR) and western blotting...
May 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28536312/effects-of-ginsenoside-rg1-loaded-alginate-chitosan-microspheres-on-human-bone-marrow-stromal-cells
#3
Yu-Hai Guo, Shuai Zhao, Yan-Xin Du, Qing-Jia Xing, Bo-Lai Chen, Chu-Qin Yu
The ginsenoside Rg1 is the most abundant compound of ginseng. Recent studies showed that Rg1 had neuroprotective effect on neuronal cells. This study was to prepare Rg1-loaded alginate-chitosan microspheres and research the effects of the microspheres on human bone marrow stromal cell (hBMSC). The alginate-chitosan microspheres were prepared by mechanical emulsification technique in combination with ion (Ca(2+)) and chitosan solidification. Subsequently, the microspheres were employed to load ginseng extracts Rg1...
May 23, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28536311/vascular-endothelial-growth-factor-vegf-modified-macrophages-transdifferentiate-into-endothelial-like-cells-and-decrease-foam-cell-formation
#4
Dan Yan, Yujuan He, Jun Dai, Lili Yang, Xiaoyan Wang, Qiurong Ruan
Macrophages are largely involved in the whole process of atherosclerosis from an initiation lesion to an advanced lesion. Endothelial disruption is the initial step and macrophage-derived foam cells are the hallmark of atherosclerosis. Promotion of vascular integrity and inhibition of foam cell formation are two important strategies for preventing atherosclerosis. How can we inhibit even reverse the negative role of macrophages in atherosclerosis? This study was performed to investigate if overexpressing endogenous human vascular endothelial growth factor (VEGF) could facilitate transdifferentiation of macrophages into endothelial-like cells (ELCs) and inhibit foam cell formation...
May 23, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28536310/the-prognostic-values-of-signal-transducers-activators-of-transcription-family-in-ovarian-cancer
#5
Saisai Li, Bo Sheng, Menghuang Zhao, Qi Shen, Haiyan Zhu, Xueqiong Zhu
Signal transducers activators of transcription (STATs), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion and metastasis in various cancer types. In addition, STATs family have been well studied as a prognostic predictor for a considerable number of solid tumors. However, the prognostic value of STATs family in ovarian cancer patients remains unclear...
May 23, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533427/copy-number-variations-independently-induce-autism-spectrum-disorder
#6
Yingjun Xie, Haiming Yuan, Mingbang Wang, Liangying Zhong, Jiaxiu Zhou, Bing Song, Qibin Yin, Xiaofang Sun
The examination of copy number variation (CNV) is critical to understanding the etiology of the CNV-related autism spectrum disorders (ASD). DNA samples were obtained from 64 ASD probands, which were genotyped on an Affymetrix CytoScan HD platform. qPCR or FISH were used as a validation for some novel recurrent CNVs. We further compared the clinical phenotypes of the genes in the DECIPHER database with these overlapping genes.  Using vast, readily available databases with previously reported clinically relevant CNVs from human populations, the genes were evaluated using Enrichment Analysis and GO Slim Classification...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533426/a-reappraised-meta-analysis-of-the-genetic-association-between-vitamin-d-receptor-bsm-i-rs1544410-polymorphism-and-pulmonary-tuberculosis-risk
#7
Mohammed Y Areeshi, Raju K Mandal, Sajad Ahmad Dar, Abdulrahman M Alshahrani, Aqeel Ahmad, Arshad Jawed, Mohd Wahid, Mohtashim Lohani, Aditya K Panda, Shafiul Haque
BsmI (rs1544410) polymorphism located in intron 8 at the 3' end of the VDR gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR Bsm I polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In this study, an updated meta-analysis was performed to evaluate the above said association. PubMed, EMBASE, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533425/brms1gene-expressionmay-be-associated-with-clinico-pathological-features-of-breast-cancer
#8
Li-Zhong Lin, Miao-Guo Cai, Yue-Chu Dai, Zhi-Bao Zheng, Fang-Fang Jiang, Li-Li Shi, Yin Pan, Han-Bing Song
Our aim is to investigate whether or not the breast cancer metastasis suppressor 1 ( BRMS1 ) gene expression is directly linked to clinico-pathological features of breast cancer. Following a stringent inclusion and exclusion criteria, case-control studies with associations between BRMS1 and breast cancer were selected from articles obtained by way of searches conducted through an electronic database. All statistical analyses were performed with Stata 12.0 (Stata Corp, College Station, TX, USA). Ultimately, 1,263 patients with breast cancer were found in a meta-analysis retrieved from a total that included 12 studies...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28533424/comparison%C3%A2-of%C3%A2-efficacy%C3%A2-and%C3%A2-safety%C3%A2-between%C3%A2-dezocine-and%C3%A2-morphine-for-persistence-of-pain-in-cancer-patients-in-chinese-a-meta-analysis
#9
Lei Wang, Xudong Liu, Jianfeng Wang, Yingjiao Sun, Guozhuan Zhang, Lishuang Liang
   The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science and Wan Fang Med Online for the related studies up to October 2016. Summary odds ratio (OR) with 95% confidence interval (95% CI) were calculated with the random effects model...
May 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28522553/glioblastoma-derived-cells-in-vitro-unveil-the-spectrum-of-drug-resistance-capabilty-comparative-study-of-tumour-chemosensitivity-in-different-culture-systems
#10
Monika Witusik-Perkowska, Magdalena Zakrzewska, Beata Sikorska, Wielislaw Papierz, Dariusz J Jaskolski, Janusz Szemraj, Pawel P Liberski
Resistance to cancer drugs is a complex phenomenon which could be influenced by in vitro conditions. However, tumour-derived cell cultures are routinely used for studies related to mechanisms of drug responsiveness or the search for new therapeutic approaches. The purpose of our work was to identify the potential differences in drug resistance and response to treatment of glioblastoma with the use of three in vitro models: traditional adherent culture, serum-free spheroid culture and novel adherent serum-free culture...
May 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28522552/choosing-the-optimal-spectroscopic-toolkit-to-understand-protein-function
#11
Michael Hough
A wide array of spectroscopic tools are now available to characterise the properties of proteins in solution and crystalline states. A considerable challenge for a researcher with limited resources and time is to select the most appropriate set of spectroscopies to address a particular biological or biochemical question. Important factors to consider are the state of the protein (typically solution or crystal), the time domain to be explored, the presence or absence of a spectroscopically accessible chromophore and the relevance of a particular in vitro spectroscopy to protein function in vivo Different spectroscopies provide information at the global, local or atomic level and in general, for maximum biological insight, it is essential that a suitable combination of spectroscopies are applied to answer the most relevant questions...
May 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28522551/inhibition-of-mir-143-during-ischemia-cerebral-injury-protects-neurons-through-recovery-of-the-hexokinase-2-mediated-glucose%C3%A2-uptake
#12
Xianzhu Zeng, Na Liu, Jing Zhang, Lei Wang, Zhecheng Zhang, Ju Zhu, Qian Li, Yuwen Wang
Ischemic stroke, a major cause of death, is caused by occlusion of a blood vessel, resulting in a significant reduction in regional cerebral blood flow. MicroRNAs (miRNAs) are a family of short noncoding RNAs (18 to 22 nucleotides) and bind the 3' un-translated region (UTR) of their target genes to post-transcriptionally suppress gene expression. In this study, we report miR-143 is downregulated in rat neurons but high expressed in astrocytes cells. In vivo middle cerebral artery occlusion (MCAO) and ex vivo oxygen-glucose deprivation (OGD) results showed miR-143 was significantly induced by ischemia injury...
May 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28522550/suppression-of-microrna-135b-5pprotects-againstmyocardial-ischemia-reperfusion-injury-by-activatingjak2-stat3-signaling-pathway-in-mice-duringsevofluraneanesthesia
#13
Xiao-Juan Xie, Dong-Mei Fan, Kai Xi, Ya-Wei Chen, Peng-Wei Qi, Qian-Hui Li, Liang Fang, Li-Gang Ma
The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating JAK2/STAT signaling pathway by mediating inhalation anesthesia with sevoflurane. A sum of 120 healthy Wistar male mice was assigned into six groups. Left ventricular ejection fraction (LVEF) and left ventricular shortening fraction (LVSF) were detected. Cardiomyocyte apoptosis was determined by TUNEL assay. MiR-135b-5p expression, mRNA and protein expression of p-STAT3, p-JAK2, STAT3, JAK2, Bcl2 and Bax were detected by qRT-PCR and Western blotting...
May 18, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28515223/associations-between-male-reproductive-characteristics-and-the-outcome-of-assisted-reproductive-technology-art
#14
Zhangshun Liu, Xiaohong Shi, Lihong Wang, Yan Yang, Qiang Fu, Minfang Tao
This study was designed to investigate the relationships between indicators of male body-mass index (BMI), age, reproductive hormone levels, semen parameters and the outcomes of assisted reproductive technology (ART). The clinical data were collected from 636 couples who underwent ART at the reproductive center involved in our study. Pearson's correlation or Spearman rank correlation was applied to establish the relevant correlation coefficients. The correlation between influence factors' and pregnancy outcomes was analyzed using the Logistic regression model...
May 17, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28515222/zebrafish-models-for-functional-and-toxicological-screening-of-nanoscale-drug-delivery-systems-promoting-preclinical-applications
#15
Keon Yong Lee, Gun Hyuk Jang, Cho Hyun Byun, Minhong Jeun, Peter Searson, Kwan Hyi Lee
Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time consuming. Zebrafish models represent an alternative for preclinical studies of nanoscale drug delivery systems. These models allow easy optical imaging, large sample size, and organ-specific studies, and hence an increasing number of preclinical studies are employing zebrafish models...
May 17, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28515221/regulation-of-cerebral-arterial-bkca-channels-by-angiotensin-ii-signaling-in-adult-offspring-exposed-to-prenatal-high-sucrose-diets
#16
Xiuxia Gu, Axin He, Xiaorong Fan, Ruixiu Shi, Xueqin Feng, Le Bo, Lin Jiang, Na Li, Jue Wu, Yuxian Yang, Qinqin Gao, Zhice Xu
Prenatal insults have been shown to affect vascular functions, leading to increased risks of cardiovascular diseases in offspring. The present study determined whether high sucrose intake in pregnancy affected central vascular functions in middle cerebral artery (MCA) of offspring. Sprague-Dawley rats were fed a standard food and tap water with normal or high (20%) sucrose content during pregnancy. Offspring were maintained with normal diets and tap water. Central vascular functions and related ion channels were assessed in male offspring at 5 months old...
May 17, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28507202/determination-of-volatile-organic-compounds-exhaled-by-cell-lines-derived-from-hematological-malignancies
#17
Hongxia Tang, Yan Lu, Lulu Zhang, Zhonghui Wu, Xiaofang Hou, Hailong Xia
Background: The gas human exhaled contains many volatile organic compounds (VOCs), which is related to the health status of body. Analysis of VOCs has been proposed as a noninvasive diagnostic tool for certain cancers. Detailed research on the VOCs in gas exhaled by cell can characterize cell type specific metabolites and may be helpful to detect the cancer markers in clinical practice. Methods: Solid phase microextraction-gas chromatography-mass spectrometry was used to detect VOCs in the headspace of tissue culture flask in non-Hodgkin's lymphoma cell line JEKO and acute mononuclear leukemia cell line SHI-1, to elaborate the characteristic gaseous biomarkers of hematological malignancies...
May 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28507201/sensitivity-of-non-small-cell-lung-cancer-to-erlotinib-is-regulated-by-the-notch-mir-223-fbxw7-pathway
#18
Haiwei Zhang, Fanglin Chen, Yongpeng He, Lin Yi, Chuang Ge, Xiaolong Shi, Chao Tang, Donglin Wang, Yongzhong Wu, Weiqi Nian
Recent evidence supports a role for microRNA-223 (miR-223) in modulating tumor cell sensitivity to chemotherapeutic drugs; however, its role in cellular resistance to the effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) used in treatment of non-small cell lung cancer (NSCLC) remains to be elucidated. The levels of miR-223 in parental cell line (HCC827) and erlotinib resistant HCC827 cell line (HCC827/ER)  were detected by qRT-PCR. HCC827/ER cells were treated with MK-2206 to block the Akt signaling pathway or RO4929097 to block the Notch signaling pathway, and then transfected with a miR-223 inhibitor or interference expression plasmid of F-Box/WD repeat-containing protein 7 (FBXW7) or insulin-like growth factor 1 receptor (IGF1R)...
May 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28507200/effects-of-microvirin-mono-and-oligomers-on-hepatitis-c-virus
#19
Yuan Qin Min, Xu Chu Duan, Yi Dan Zhou, Anna Kulinich, Meng Wang, Zhi-Peng Cai, Hong Yu Ma, Li Liu, Xiao Lian Zhang, Josef Voglmeir
Microvirin is a carbohydrate binding protein which shows high specificity for high-mannose type N-glycan structures. In this study we tried to identify whether microvirin could bind to high-mannose containing Hepatitis C Virus (HCV) envelope glycoproteins, which are heavily decorated decorated high-mannose glycans. In addition, recombinantly expressed microvirin oligomers in di-, tri-, and tetrameric form were evaluated for their viral inhibition. Microvirin oligomers bound more efficiently to HCV virions, and displayed in comparison to the microvirin monomer a higher neutralisation potency against HCV infection...
May 15, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28507199/whole-body-vibration-exercise-combined-with-an-extract-of-coriandrum-sativum-modify-some-biochemical-physiological-parameters-in-rats
#20
Éric Frederico, Andre Cardoso, Carlos Guimarães, Livia Almeida, Rosane de Figueiredo Neves, Danubia Sá-Caputo, Eloá Moreira-Marconi, Carla Dionello, Danielle Morel, Laisa Paineiras-Domingos, Rebeca Costa-Cavalcanti, Cintia Renata Souza Gonçalves, Adriano Arnóbio, Nasser Asad, Mario Bernardo-Filho
The aim of this study was to evaluate the effect of the association of WBV exercise with an aqueous extract of coriander on the biodistribution of the radiopharmaceutical sodium pertechnetate, on the concentration of some plasma biomarker, on the feed intake, on the body mass and on the stool consistency in rats. Rats were divided in four groups and submitted to different treatments for 40 days. The control group (CON) received deionized water. The group treated with coriander (COR) received the extract of coriander...
May 15, 2017: Bioscience Reports
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