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Bioscience Reports

Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wang
Maternal malnutrition lead to the incidence of metabolic diseases in offspring. The purpose of this project was to exam whether maternal low chromium could disturb normal lipid metabolism in offspring, altering adipose cell differentiation and leading the incidence of lipid metabolism diseases, including metabolic syndrome and obesity. Female C57BL mice were given a control diet (CD) or a low chromium diet (LCD) during the gestational and lactation periods. After weaning, offspring was fed with CD or LCD. The female offspring were assessed at 32 weeks of age...
March 20, 2017: Bioscience Reports
Guoyi Dong, Zhouchun Shang, Longqi Liu, Chuanyu Liu, Yuping Ge, Quanlei Wang, Liang Wu, Fang Chen, Baolin Li, Xin Liu, Xun Xu, Huanming Yang, Yutao DU, Hui Jiang
Spermatogenic lineage has been directly generated in spermatogonial stem cell (SSC) conditions from human pluripotent stem cells (PSCs). However, it remains unknown whether mouse ESCs can directly differentiate into advanced male germ cell lineage in the same conditions. Here, we showed that rather low efficiency of germ-like cell generation from mouse ESCs in SSC conditions. Interestingly, addition of retinoic acid (RA) into SSC conditions enabled efficient differentiation of mouse ESCs into germ-like cells, as shown by activating the expression of spermatogenesis-associated genes during differentiation process, such as Mvh , Dazl , Prdm14 , Stella , Scp1 , Scp3 , Stra8 and Rec8 In contrast, for cells cultured in control medium, the activation of these above genes barely occurred...
March 17, 2017: Bioscience Reports
Jun-Hua Zhong, Jing Li, Cui-Fang Liu, Ning Liu, Rui-Xiang Bian, Shou-Mei Zhao, Shu-Yi Yan, Yong-Bing Zhang
This study aims to investigate the effects of microRNA-146a (miR-146a) on the proliferation and apoptosis of human osteoarthritis (OA) chondrocytes by targeting TRAF6 through NF-κB signaling pathway. Human normal and OA chondrocytes were selected and divided into the normal group, blank group, negative control (NC) group, miR-146a mimics group, miR-146a inhibitors, miR-146a inhibitor + si-TRAF6 group and si-TRAF6 group. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the expressions of miR-146a, TRAF6 mRNA and NF-κB mRNA...
March 17, 2017: Bioscience Reports
Seiji Mori, Nobuaki Hatori, Naomasa Kawaguchi, Yoshinosuke Hamada, Tsung-Chieh Shih, Chun-Yi Wu, Kit S Lam, Nariaki Matsuura, Hirofumi Yamamoto, Yoko K Takada, Yoshikazu Takada
We recently found that integrin αvβ3 binds to FGF1, and that the integrin-binding defective FGF1 mutant (Arg-50 to Glu, R50E) is defective in signaling and antagonistic to FGF1 signaling. R50E suppressed angiogenesis and tumor growth, suggesting that R50E has potential as a therapeutic. However, FGF1 is unstable, and we had to express R50E in cancer cells for xenograft study, since injected R50E may rapidly disappear from circulation. We studied if we can develop antagonist of more stable FGF2. FGF2 is widely involved in important biological processes such as stem cell proliferation and angiogenesis...
March 16, 2017: Bioscience Reports
Jian Huang, Guoqing Pan, Hongchao Jiang, Wenliang Li, Jian Dong, Hongbin Zhang, Xiang Ji, Zhu Zhu
   The association between dietary carbohydrate intake and colorectal cancer risk remains controversial. We therefore conducted this meta-analysis to assess the relationship between them. A literature search from the databases of Pubmed, Embase, Web of science and Medline databases were performed for available articles published in English (up to Sep 2016). Pooled relative risk (RR) with 95% confidence interval (CI) was calculated to evaluate the association between dietary carbohydrate intake and colorectal cancer risk...
March 15, 2017: Bioscience Reports
Wei-Ming Wang, Xiao-Jun Ma, Shi-Bo Huang, Liu-Bao Ren, Yu-Peng Liu
This study aimed to compare the effect of autograft or allograft anterior cruciate ligament (ACL) reconstruction on the expressions of LOXs and MMPs in a New Zealand white rabbit model. New Zealand white rabbits were divided randomly into control, sham, autograft and allograft groups At the 4th and 8th week after operation, biomechanical testing was performed to measure the primary length, cross-sectional area, maximum tensile load and stiffness of ACL, and HE staining was used to observe cell morphology and fibre alignment of ACL...
March 8, 2017: Bioscience Reports
Xiaoqing Wang, Weiwei Hu, Liqi Zhu, Qian Yang
Intestinal epithelial cells are the targets for transmissible gastroenteritis virus (TGEV) infection. It is urgently to develop a novel candidate against TGEV entry. Bacillus subtilis is a probiotics with excellent anti-microorganism properties, and one of its secretions, surfactin, has been regarded as the versatile weapons for most plant pathogens, especially for the enveloped virus. We demonstrate for the first time that Bacillus subtilis OKB105 and its surfactin can effectively inhibit one animal coronavirus, TGEV, entering the intestinal porcine epithelial cell line (IPEC-J2)...
March 7, 2017: Bioscience Reports
De Ying Wei, Feng Geng, Shu Mei Liang, Hui Zhao, Ming Liu, Hong Qing Wang
The tumor microenvironment which is a highly heterogeneous entity plays crucial roles in cancer progression. As the most prominent stromal cell types, cancer-associated fibroblasts (CAFs) produce a variety of factors into the tumor microenvironment. In this study, we firstly isolated CAFs from tumor tissues of the patients with ovarian cancer and demonstrated that hepatocyte growth factor (HGF) was highly expressed in the supernatant of CAFs. CAF-derived HGF or human recombinant HGF promoted cell proliferation in human ovarian cell lines SKOV3 and HO-8910 cells...
March 3, 2017: Bioscience Reports
Kai Zhang, Dianming Jiang
Chondrocytes which are embedded within the growth-plate or the intervertebral discare sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlining the hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. In this study, we firstly examined the hypoxia-induced apoptosis, mitochondrial dysfunction and the activation of cAMP response element-binding protein (CREB) signaling in human chondrocyte cell line, C28/I2, and then investigated the regulatory role of RhoA, a well-recognized apoptosis suppressor, in such process, with gain-of-function strategy...
March 2, 2017: Bioscience Reports
Bo Zhang, Ye Yao, Qing-Feng Sun, Si-Qi Liu, Bao Jing, Chao Yuan, Xin-Yu Liu, Tong Jiao, Hao-Cheng Li, Hai-Yang Wang
Objectives: This study was designed to investigate the role of circulating microRNA-21 (miR-21) in vascular restenosis of lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. Methods: A total of 412 LEAOD patients were enrolled randomly in this study. According to computed tomography angiography (CTA) and ankle-brachial index (ABI), patients were assigned into the restenosis group and the non-restenosis group. miR-21 expression was detected with quantitative real-time polymerase chain reaction (qRT-PCR) before and after patients underwent interventional therapy...
March 1, 2017: Bioscience Reports
Umapathy Dhamodharan, Krishnamoorthy Ezhilarasi, Balashanmugam Ponjayanthi, Dornadula Sireesh, Kunka Mohanram Ramkumar, Vijay Viswanathan
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease, characterized by progressive albuminuria and conferring additional risk of cardiovascular disease and mortality. The crucial role of heat-shock proteins (HSPs) on renal function in patients with DN has been well documented. This study was aimed to understand the association of HSP-70 gene variants on the susceptibility of type 2 diabetes mellitus (T2DM) and DN. A total of 946 subjects (549M; 397F) were recruited and divided into four groups according to the levels of urinary albumin excretion (UAE): those with normoalbuminuria (UAE300 mg/24 hour; n=230)...
February 28, 2017: Bioscience Reports
Na Li, Wei Zhang
Recently, autophagy has been indicated to play an essential role in various biological events, such as the response of cervical cancer cells to chemotherapy. However, the exact signaling mechanism that regulates autophagy during chemotherapy remains unclear. In this study, we investigated the regulation by Cisplatin on Protein kinase C beta (PKC β), on B-cell lymphoma 2 (Bcl-2) and on apoptosis in cervical cancer Hela cells. And then we examined the regulation by Cisplatin on autophagy and the role of autophagy on the chemotherapy in Hela cells...
February 28, 2017: Bioscience Reports
Jiayu Zhang, Maochong Chen, Jiawei Chen, Sisi Lin, Daqiu Cai, Chengwei Chen, Zhenguo Chen
Background: Diabetic retinopathy (DR) is the complication of diabetic mellitus (DM), and is a leading cause of vision loss globally. However, the pathogenic mechanism and clinical therapy still needs further improvement. The biologic significance of myocardial infarction associated transcript (MIAT) in DR remains unknown, Here we aims to explore the mechanism between MIAT and DR, which was essential for RD. Method: Streptozotocin(STZ) was used to induce DM mice, and high glucose was used to stimulate cells...
February 28, 2017: Bioscience Reports
Haithem A Farghali, Naglaa A AbdElKader, Marwa S Khattab, Huda O Abubakr
Background: Platelet-rich plasma (PRP) is known to be rich in growth factors and cytokines which are crucial to the healing process. Objective: Studying the effect of subcutaneous infiltration of autologous PRP at the wound boundaries on wound epithelization and contraction. Material and Methods: Five adult male mongrel dogs were used. Bilateral acute full-thickness skin wounds (3cm diameter) were created on the thorax symmetrically. Right side wounds were subcutaneously infiltrated with activated PRP at day zero then every week for three consecutive weeks...
February 28, 2017: Bioscience Reports
Li Zhang, Huaijun Liu, Xiaodan Mu, Jianling Cui, Zhigang Peng
Aberrant expression of Fos-related antigen-1 (Fra1) is commonly elevated in various malignant cancers and is strongly implicated in invasion and metastasis. However, the molecular mechanisms underlying its dysregulation in human glioma remain poorly understood. In the present study we demonstrate that upregulation of Fra1 plays a crucial role in the glioma aggressiveness and epithelial-mesenchymal transition activated by Wnt/β-catenin signal pathway. In glioma cells, activation of Wnt/β-catenin signaling by Wnt3a administration obviously induced epithelial-mesenchymal transition (EMT) and directly activated the transcription of Fra1...
February 23, 2017: Bioscience Reports
Yuchen Zhang, Junjun Cheng, Fang Chen, Changyan Wu, Junmeng Zhang, Xuejun Ren, Yu Pan, Bin Nie, Quan Li, Yu Li
Background : Microparticles (MPs) and microRNAs (miRNAs) have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. This study aims to investigate the diagnostic value of endothelial microparticles (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocardial infarction (AMI) from those with CAD. Methods : Plasma samples from 37 patients with AMI, 42 patients with stable coronary artery disease (SCAD) and 35 healthy adults were collected for investigation in this study...
February 17, 2017: Bioscience Reports
Youngtak Cho, Narae Shin, Daesan Kim, Jae Yeol Park, Seunghun Hong
This paper provides a concise review on the recent development of nanoscale hybrid systems based on carbon nanotubes (CNTs) for biological sensing and control. CNT-based hybrid systems have been intensively studied for versatile applications of biological interfaces such as sensing, cell therapy, and tissue regeneration. Recent advances in nanobiotechnology not only enable the fabrication of highly-sensitive biosensors at nanoscale but also allow the applications in the controls of cell growth and differentiation...
February 10, 2017: Bioscience Reports
Dawei Wang, Guoliang Lu, Yuan Shao, Da Xu
Objective: MicroRNAs (miRNAs) are a class of non-coding RNAs that exert critical roles in various biological processes. The target of the present study was to identify the functional roles of microRNA-802 (miR-802) in regulating epithelial-mesenchymal transition (EMT) in prostate cancer (PCa). Methods: miR-802 expression was investigated in 73 pairs of PCa samples and PCa cell lines (PC3 and DU145 cells) by qRT-PCR. Cell proliferation was detected using MTT assay, and cell apoptosis was evaluated using flow cytometry...
February 10, 2017: Bioscience Reports
Jia Zheng, Jing Cheng, Qian Zhang, Xinhua Xiao
Recent epidemiological and clinical studies have shown that type 2 diabetic patients can develop diabetic vascular complications even after intensive glycemic control. It has been suggested that this phenomenon could be explained by the hypothesis of "metabolic memory". The underlying mechanisms between these enduring effects and the prior hyperglycemic state are still not well understood. Preliminary studies demonstrate that hyperglycemia can regulate gene expression by epigenetic modifications, such as DNA methylation, which can persistently exist even after glucose normalization...
February 9, 2017: Bioscience Reports
Zhi-da Wang, Yu-Fei Xia, Yue Zhao, Li-Ming Chen
This meta-analysis was performed to evaluate the effect of cognitive behavioral therapy (CBT) in improving the depression symptoms of patients with diabetes. Literature search was conducted in PubMed and Embase up to Oct 2016 without initial date. The pooled SMD (standard mean difference) and its 95% confidence interval (CI) were calculated by Revman 5.3. Subgroup analyses were performed by type of diabetes and evaluation criteria of depression. A total of 5 randomized control trials involving 834 patients with diabetes mellitus (including 417 patients in CBT group and 417 patients in control group) were included in this meta-analysis...
February 9, 2017: Bioscience Reports
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