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Bioscience Reports

Bisha Ding, Weiyang Lou, Liang Xu, Weimin Fan
Hepatocellular carcinoma (HCC) has been one of the most highly lethal cancers. The acquisition of drug resistance accounts for the majority of poor effects of chemotherapy in HCC. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment and prognosis of HCC...
September 17, 2018: Bioscience Reports
Lijun Peng, Yan Zhong, Aiping Wu, Zhisheng Jiang
We conducted a meta-analysis to evaluate the effect of probiotic combined with aminosalicylic on induction remission maintenance treatment of ulcerative colitis. We conducted systematic searches in several Chinses and English databases from inception to June 2018, screening randomized controlled trial about effect of probiotics combined with aminosalicylic acid on ulcerative colitis. The evaluation indicator was the rate of remission. The relative risk (RR) and 95% confidence interval (CI) were calculated. A total of twenty-seven studies with 1942 patients were included...
September 17, 2018: Bioscience Reports
Xinyue Yang, Yan Cheng, Guanfang Su
Angiopoietin-like protein 4 is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations on these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy, age-related macular degeneration, retinal vein occlusion and sickle cell retinopathy. However, the role of ANGPTL4 in these diseases remains controversial. Here, we summarize the functional mechanisms of ANGPTL4 in several diseases. We highlight original studies that provide detailed data about the mechanisms of action for ANGPTL4, its applications as a diagnostic or prognostic biomarker, and its use as a potential therapeutic target...
September 17, 2018: Bioscience Reports
Qian Hou, Ke Hu, Xiaofeng Liu, Jiao Quan, Zehao Liu
Vascular dysfunction is a common result of diabetes in human. However, the mechanism underlying diabetic vascular dysfunction is not fully understood. Here in this study, we showed that the histone deacetylase 2 (HDAC2) promoted the endothelial dysfunction induced by diabetes. The expression and activity of HDAC2 were up-regulated in vascular endothelial cells from diabetic patients and mice. The expression of HDAC2 was also increased by high glucose stress in isolated human endothelial cells. HDAC2 knockdown repressed the proliferation rate and promoted high-glucose-induced apoptosis of endothelial cells, which was associated with the activation of apoptotic pathways (Bcl-2, Caspase 3 and Bax)...
September 14, 2018: Bioscience Reports
Guangjun Jin, Zhu Chen, Jiancheng Zhang, Jia Song, Jun Shi, Bingzhi Zhou
OBJECTIVE: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms and chronic obstructive pulmonary disease (COPD) and COPD with pulmonary hypertension (PH) and to analyze its mechanism. METHODS: The genotypes of BNP at the rs198389, rs6668352, and rs198388 loci in 339 patients with COPD (205 in the COPD/PH- group and 134 in the COPD/PH+ group) and 125 healthy subjects were detected by PCR/Sanger sequencing. The serum levels of BNP, Fbg and Apelin were measured in all subjects by ELISA...
September 14, 2018: Bioscience Reports
Adel Qlayel Alkhediade, Tamer Ahmed Ismail, Saad Hmoud Alotaibi, Mohamed Abdo Nassan, Zafer Saad Al Shehri
Obstructive cholestasis characterized by biliary pressure increase leading to a leakage of bile back which causes liver injury. This study aims to evaluate the effects of artemisinin in obstructive cholestasis in mice. The present study was carried out on 40 adult healthy mice which were divided into 4 groups, 10 mice each; the negative control group didn't receive any medication. The normal group was fed normally with 100 mg/kg of Artemisinin extract orally. The cholestatic group fed on 1% lithocholic acid (LCA) mixed into control diet and cholestatic group co-treated with 100 mg/kg of Artemisinin extract orally...
September 14, 2018: Bioscience Reports
Siying Zhou, Yunjie He, Sujin Yang, Jiahua Hu, Qian Zhang, Wei Chen, Hanzi Xu, Heda Zhang, Shanliang Zhong, Jianhua Zhao, Jinhai Tang
Breast cancer (BC) is the most common cancer and principal cause of death among females worldwide. Invasion and metastasis are major causes which influence the survival and prognosis of BC. Therefore, to understand the molecule mechanism underlying invasion and metastasis is paramount for developing strategies to improve survival and prognosis in BC patients. Recent studies have reported that long non-coding RNAs (lncRNAs) play critical roles in the regulation of BC invasion and metastasis through a variety of molecule mechanisms that endow cells with an aggressive phenotype...
September 14, 2018: Bioscience Reports
Xiaoyun Li, Xiaoxia Wei, Chaojin Chen, Zheng Zhang, Dezhao Liu, Ziqing Hei, Weifeng Yao
Postoperative pulmonary complications (PPCs) following orthotopic liver transplantation (OLT) are associated with high morbidity and mortality rates. The effect of N-acetylcysteine (NAC) inhalation on the incidence of PPCs and the outcomes of patients undergoing OLT is unknown. This prospective randomized controlled clinical trial was conducted to investigate the effect of NAC inhalation during OLT on PPCs. Sixty patients were randomly assigned to the NAC group (n=30) or the control group (n=30) to receive inhaled NAC or sterilized water, respectively, for 30 min before surgery and 3 h after reperfusion...
September 14, 2018: Bioscience Reports
Di Liu, Xin Jin, Chunqi Zhang, You Shang
PURPOSE:  This article aimed to study the role of sevoflurane pre-conditioning in hepatic ischemia-reperfusion and its potential mechanism. METHODS: Rat liver ischemia-reperfusion model was constructed. Serum TNF-α, IL-1β, IL-10 and IL-6 concentrations were detected by ELISA. MDA, SOD and NO in liver homogenate was determined. HE staining, Tunel and immunohistochemistry were performed. Ischemia/reperfusion hepatocyte model was established. Cells transfection was conducted...
September 14, 2018: Bioscience Reports
Andrew Cubbon, Ivana Ivancic-Bace, Edward L Bolt
Co-opting of CRISPR-Cas "Interference" reactions for editing the genomes of eukaryotic and prokaryotic cells has highlighted crucial support roles for DNA repair systems that strive to maintain genome stability. As front-runners in genome editing that targets DNA, the class 2 CRISPR-Cas enzymes Cas9 and Cas12a rely on repair of DNA double-strand breaks (DDSBs) by host DNA repair enzymes, using mechanisms that vary in how well they are understood. Data is emerging about the identities of DNA repair enzymes that support genome editing in human cells...
September 12, 2018: Bioscience Reports
Chris J Charles, David L Jardine, Miriam T Rademaker, A Mark Richards
While it is well established that centrally injected angiotensin II (Ang II) has potent actions on sympathetic nervous activity (SNA) it is less clear whether peripheral Ang II can immediately stimulate SNA. In particular the contribution of cardiac sympathetic nerve activity (CSNA) to the acute pressor response is unknown. We therefore examined the effect of incremental doses of intravenous Ang II (3, 6, 12, 24 and 48 ng/kg/min each for 30 min) on CSNA in eight conscious sheep. Ang II infusions progressively increased plasma Ang II up to 50pmol/L above control levels in dose dependent fashion (p<0...
September 11, 2018: Bioscience Reports
Bin Zhu, Juan Wang, Ling Ling Qin, Lei Wang, Yan Fei Zheng, Lei Zhang, Wei Wang
The association of the fibroblast growth factor receptor 2 gene ( FGFR2 ) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated. We thus investigated a potential association of rs2981582 with NFPA. A total of 79 patients and 142 healthy control participants were enrolled in our study. DNA of the participants was extracted from peripheral blood samples and genotyped by using the MassARRAY method...
September 11, 2018: Bioscience Reports
Ibtsam Gheith, Abubakr El-Mahmoudy
This study has aimed at utilization of novel and classical kidney function biomarkers to evaluate the nephroprotective potential of Carica papaya leaf extract (CPLE) in gentamicin nephrotoxicity model. The used classical biomarkers were urea and creatinine; while the new biomarkers were Kidney injury molecule-1 (KIM-1) and Clusterin. Forty-five male albino rats were assigned into 5 groups and subjected to different treatments for 9 consecutive days (vehicles; gentamicin, 100 mg/kg, subcutaneously; ascorbic acid, 200 mg/kg, orally; Carica papaya leaf extract, CPLE, 150 and 300 mg/kg b wt...
September 11, 2018: Bioscience Reports
Marion Marlinge, Pierre Deharo, Joulia Fabrice, Mathieu Coulange, Donato Vairo, M Gaudry, Mylene Egensperger, Laura Belkhiri, Myriam Zouggarh, Laurie Bruzzese, Julien Fromonot, Théo Charnay, Camille Petit, Claire Guiol, Giovanna Mottola, Amin Ben Lassoued, Alain Boussuges, Régis Guieu, Pierre Louge
Immersion pulmonary edema (IPE) is a serious complication of water immersion during SCUBA diving. Myocardial ischemia can occur during IPE that worsened outcome. Because myocardial injury impacts the therapeutic management, we aim to evaluate the profile of cardiac markers (creatine phosphokinase (CPK), BNP, troponin T (TnT-hs) and troponin I (TnI-us) of divers with IPE. 12 male SCUBA divers admitted for suspected IPE were included. The collection of blood samples was performed at hospital entrance (T0) and 6 hours later (T0+6 hours)...
September 10, 2018: Bioscience Reports
Xiaoming Liu, Dongli Wang, Xiaoni Yang, Lei Lei
Receptor of advanced glycation end products (AGE) is a membrane protein that contribute to the initiation and progression of diabetic vascular complications, which is reported as a target of miR-185. Huayu Tongmai Granules are a Chinese herbal compound that is capable of treating diabetic angiopathy. This study was designed to explore the molecular biological mechanism by which Huayu Tongmai Granules protect against diabetic angiopathy. Methods The rat model of diabetes and hyperglucose cell model were established...
September 10, 2018: Bioscience Reports
Alfonso Olivos-García, Mario Nequiz, Scarlet Liceaga, Edith Mendoza, Porfirio Zúñiga, Azucena Cortes, Gabriel López-Velázquez, Sergio Enríquez-Flores, Emma Saavedra, Ruy Pérez-Tamayo
Amoebiasis is a parasitic disease caused by Entamoeba histolytica This illness is prevalent in poor countries causing one hundred thousand deaths worldwide. Knowledge of the natural resistance mechanisms of rats to amoebic liver abscess (ALA) development may help to discover new pathogenic factors and to design novel therapeutic strategies against amoebiasis. In this work, histologic analyses suggested that the complement system may play a central role in rat natural resistance to ALA. E. histolytica trophozoites disappeared from rat liver within 3 h post-infection with minimal or no inflammatory infiltrate...
September 10, 2018: Bioscience Reports
Hyo Jung Kim, Ae-Ran Kwon, Bong-Jin Lee
The characteristic fold of a protein is the decisive factor for its biological function. However, small structural changes to amino acids can also affect their function, for example in the case of post- translational modification (PTM). Many different types of PTMs are known, but for some, including chlorination, studies elucidating their importance are limited. A recent study revealed that the YjgF family member RidA from Escherichia coli shows chaperone activity after chlorination. Thus, to identify the functional and structural difference of RidA upon chlorination, we studied a RidA homologue from Staphylococcus aureus : YabJ...
September 10, 2018: Bioscience Reports
Xuan Zhang, Juan Wang, Xi Chen, Menglu Yu, Shuangbin Yu, Yuanyuan Sun, Jinchao Duan, Hongying Sun, Ping Yuan
World Health Organization recommend HBV immunization at 0, 1, and 6 months. However, studies have suggested that shortening the interval between the first and last HBV immunization can improve completion rates. Less clear is whether accelerated immunization is as immunogenic as standard immunization. Thus, this study aimed to compare the short-term immunogenicity of yeast-derived hepatitis B vaccine in healthy adults immunized on an accelerated or standard schedule. Between June 2013 and March 2014, individuals from Jinfeng and Longmen, China were randomly assigned to receive the vaccine on an accelerated schedule (at 0, 1, and 2 months; n = 201) or a standard schedule (at 0, 1, and 6 months; n = 206)...
September 10, 2018: Bioscience Reports
Wei-Xian Chen, Ling-Yun Xu, Qi Qian, Xiao He, Wen-Ting Peng, Yu-Lan Zhu, Lin Cheng
A major cause of failure in chemotherapy is drug resistance of cancer cells. Exosomes have been introduced to spread chemoresistance through delivering microRNAs (miRNAs). However, a systematic evaluation of the exosomal miRNA expression profiles responsible for chemoresistance is still lacking. In the present study, miRNA signature differentially expressed in exosomes derived from adriamycin-resistant (A/exo) and parental breast cancer cells (S/exo) were analyzed by microarray and the results were confirmed by polymerase chain reaction...
September 10, 2018: Bioscience Reports
V Larosa, C Remacle
Reactive oxygen species (ROS) are highly reactive reduced oxygen molecules that result from aerobic metabolism. The common forms are the superoxide anion () and hydrogen peroxide (H2 O2 ) and their derived forms, hydroxyl radical (HO∙) and hydroperoxyl radical (HOO∙).Their production sites in mitochondria are reviewed. Even though being highly toxic products, ROS seem important in transducing information from dysfunctional mitochondria. Evidences of signal transduction mediated by ROS in mitochondrial deficiency contexts are then presented in different organisms such as yeast, mammals or photosynthetic organisms...
September 10, 2018: Bioscience Reports
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