journal
https://read.qxmd.com/read/37658539/lipaemic-serum-in-hb-e-beta-thalassaemia-major-a-rare-case-of-hypertriglyceridaemia-thalassaemia-syndrome
#21
JOURNAL ARTICLE
N A Mohd Kasim, N S Mohd Nor, M T Wen, S K A Syed Kamaruddin, S H Sheikh Abdul Kadir
INTRODUCTION: A 1-year-old Malay girl presented with pallor, failure to thrive and hepatosplenomegaly. Her blood was sent for thalassaemia screening and it was incidentally found that her blood appeared lipaemic. CASE REPORT: Primary and secondary causes of hyperlipidaemia were investigated. Her blood was sent for fasting lipid profile, thyroid function test (TFT), fasting plasma glucose (FPG), liver function test (LFT), renal profile (RP) and HIV screening. Lipaemic interference was removed by high-speed centrifugation...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658538/pancoast-syndrome-due-to-pulmonary-metastasis-of-sarcomatoid-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
R Hoo, V G Shelat
INTRODUCTION: Hepatocellular carcinoma is the most common primary liver malignancy, and sarcomatoid hepatocellular carcinoma is a rare malignancy containing both carcinomatous and sarcomatous components. CASE REPORT: We report a 64-year-old male patient treated with open right trisectionectomy for a 16cm right hemiliver tumour. The diagnosis of sarcomatoid hepatocellular carcinoma was confirmed on histology. Five months after hepatic resection, patient had symptoms suggestive of Horner's syndrome along with left sided shoulder pain, hand weakness, reduced power of the intrinsic hand muscles and reduced pain perception over the C8/T1 dermatome...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658537/synchronous-primary-malignancies-of-papillary-thyroid-carcinoma-and-hodgkin-lymphoma-interventions-and-outcome
#23
JOURNAL ARTICLE
A Abd Rahim, R Muhammad, F Ismail, Y P Wong, R Che Abdul Aziz, G Y Chong, W F Wan Jamaludin
Thyroid carcinoma is uncommon. Papillary thyroid carcinoma (PTC) represents the majority of differentiated thyroid carcinoma and is a recognised complication of prior exposure to ionizing radiation. Even more uncommon is the synchronous occurrence of PTC with Hodgkin lymphoma (HL) as multiple primary malignancies. We report a 33-year-old mother of three who developed asymptomatic thyroid nodule for four years, and neck swelling for the recent ten months. She denied constitutional symptoms or B symptoms, and thyroid profiles were normal...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658536/globus-pharyngeus-due-to-a-lymphangiomatous-polyp-arising-from-the-tonsil
#24
JOURNAL ARTICLE
C X Tan, S W Yeo, Y P Wong, G C Tan
INTRODUCTION: Lymphangiomatous polyp of the tonsil is generally accepted as a hamartomatous lesion. Its differential diagnosis includes fibroepithelial polyp, squamous papilloma, angiofibroma, haemangioma, arteriovenous malformation, hamartoma and lymphangioma. CASE REPORT: A 33-year-old man presented with 2 months history of feeling of foreign body sensation in the throat. Examination revealed a nodular red coloured polyp on the left tonsil. Histologically, the polyp was covered by squamous epithelium and is composed of numerous vascular channels containing lymphocytes and eosinophilic material, in a fibrous stroma...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658535/demethylases-of-h3-lysine-27-h3k27-expression-in-urothelial-carcinoma-uc-of-the-urinary-bladder
#25
JOURNAL ARTICLE
R Anthony, R Rajandram, N Y Yap, K S Mun, P N Samberkar, S Kuppusamy
BACKGROUND: Ubiquitously Transcribed Tetracopeptide Repeat on X Chromosome (UTX) and Jumonji Domain-Containing Protein 3 (JMJD3) are histone H3 lysine 27 (H3K27) demethylases that are found to play tumour suppressor or oncogenic roles in many cancers. However, their roles in urothelial carcinoma (UC) have not been well studied. OBJECTIVE: This study investigated UTX and JMJD3 protein expression patterns in UC and assess their clinical significance. PATIENTS AND METHODS: Immunohistochemistry (IHC) method was performed on formalin-fixed paraffin-embedded (FFPE) of UC tissues and compared to the normal bladder tissues from the autopsy specimen...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658534/genetically-engineered-human-umbilical-cord-derived-mesenchymal-stem-cells-expressing-human-interleukin-12-and-in-vitro-growth-inhibition-against-lung-adenocarcinoma-cells
#26
JOURNAL ARTICLE
J J Goh, H T Ong, B S Lee, H K Teoh
INTRODUCTION: Mesenchymal stromal cells (MSCs) are promising vehicles for cancer therapy due to their homing ability and potency to be genetically manipulated through either viral or non-viral methods. Interleukin-12 (IL-12) is one of the key immunomodulatory cytokines which has anti-tumour effect. However, systemic administration of the cytokine at therapeutic dosage can cause serious toxicity in the host system due to the high systemic level of interferon-γ (IFN-γ) induced...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658533/clinicopathological-correlation-of-oral-candidiasis-our-experience-in-a-tertiary-centre-over-two-decades
#27
JOURNAL ARTICLE
C C Tan, D Lim, N Q Mohd Hisham, N A Elias, A S Azli, Y C Goh
INTRODUCTION: Oral candidiasis is one of the most common fungal infections that has been widely reported around the world. In Malaysia, the available studies for this infection are scarce. MATERIALS AND METHODS: This is a 20-year retrospective study aimed to investigate the prevalence, demographic characteristics, clinical presentations, and the association of oral candidiasis with clinical parameters in oral candidiasis cases reported in the Faculty of Dentistry, Universiti Malaya from 1999 until 2019...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658532/immunohistochemical-expression-of-cd117-in-borderline-low-and-high-grade-ovarian-surface-epithelial-tumours-a-clinicopathological-study
#28
JOURNAL ARTICLE
S A Al-Shami, M M Al-Kaabi, A K Mahdi, Z Al-Attar
INTRODUCTION: Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis. AIM: To evaluate CD117 expression in ovarian surface epithelial tumours...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658531/performance-evaluation-of-two-multiplex-qualitative-rt-pcr-assays-for-detection-of-respiratory-infection-in-paediatric-population
#29
JOURNAL ARTICLE
U Ali, M Zainal, Z Zainol, C W Tai, S F Tang, P C Lee, K K Wong
INTRODUCTION: Acute respiratory infection (ARI) contributes to significant mortality and morbidity worldwide and is usually caused by a wide range of respiratory pathogens. This study aims to describe the performance of QIAstat-Dx® Respiratory Panel V2 (RP) and RespiFinder® 2SMART assays for respiratory pathogens detection. MATERIALS AND METHODS: A total of 110 nasopharyngeal swabs (NPS) were collected from children aged one month to 12 years old who were admitted with ARI in UKMMC during a one-year period...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658530/morphological-cytogenetic-and-molecular-characterisation-of-flt3-mutations-in-pakistani-patients-with-de-novo-acute-myeloid-leukaemia-a-single-centre-experience
#30
JOURNAL ARTICLE
M Faiz, F Rashid
INTRODUCTION: Mutations in FLT3 are the most commonly reported genetic changes in AML patients. These mutations are normally identified in approximately one third of newly diagnosed patients and are reported to have prognostic significance. MATERIALS AND METHODS: Peripheral blood samples was collected from 63 AML patients to study their morphological, cytogenetic and molecular features. PCR was used to determine the prevalence of FLT3 mutations; internal tandem duplication (ITD) and tyrosine kinase domain (TKD) in AML patients...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658529/increased-tube-formation-and-up-regulation-of-fgfr3-mrna-expression-in-microvascular-endothelial-cell-by-exosomes-derived-from-sw480-7
#31
JOURNAL ARTICLE
C T Ng, W K Yip, N Mohtarrudin, M F Jabar, H F Seow
INTRODUCTION: Extracellular vesicles (exosome-like vesicles) are small membrane vesicles ranging from 20-200nm in size that are released by various cells into the extracellular space. These extracellular vesicles play a major role in cell-to-cell communication and contain materials, such as proteins, mRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The effect of exosomes derived from an invasive colon cancer cell line on angiogenesis is unclear. Hence, the aim of this study is to investigate the effect of exosomes derived from an invasive colon cancer cell line on angiogenesis of endothelial cells...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658528/transfusion-medicine-knowledge-among-clinicians-at-a-teaching-hospital-in-malaysia
#32
JOURNAL ARTICLE
K Y Poh, N Jackson
INTRODUCTION: Inappropriate use of blood and blood products has been well reported from many countries including Malaysia and may be due to a deficit of transfusion medicine (TM) knowledge. This study is aimed to assess TM knowledge among clinicians in a tertiary hospital. MATERIALS AND METHODS: The validated exam developed by the BEST collaborative group was used to assess TM knowledge of doctors, from junior residents up to senior specialists. Scores of 42%, 62%, and 82%, corresponding to basic, intermediate, and expert levels of knowledge, respectively...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658527/liquid-biopsy-in-breast-carcinoma-are-we-there-yet
#33
JOURNAL ARTICLE
H D Wijesinghe, M D S Lokuhetty
Breast carcinoma is the most common malignancy among women worldwide. Liquid biopsy is a method of obtaining tumour-derived material from blood and body fluid. This includes the assessment of circulating tumour cells (CTCs), circulating tumour deoxyribose nucleic acid (ctDNA), tumour educated platelets (TEPs) and exosomes. Detection of CTCs and ctDNA in liquid biopsy has been shown to have prognostic and predictive value in both early and metastatic breast carcinoma. The study of CTCs could also advance our understanding of aspects of tumour biology, including epithelial mesenchymal transition...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658526/the-recognition-of-anti-nuclear-antibody-s-dense-fine-speckled-pattern-and-the-detection-of-anti-dfs70-antibodies-in-the-laboratory-practice-its-prevalence-and-clinical-significance
#34
REVIEW
A A Wahab, E J Jauhary, C H Ding
Anti-nuclear antibody test (ANA) is the test commonly requested for the working diagnosis of systemic autoimmune rheumatic diseases (SARDs) particularly in ANA-associated rheumatic diseases (AARDs) such as SLE, systemic sclerosis, Sjogren syndrome, mixed connective tissue diseases, and dermatomyositis. Dense fine speckled (DFS) pattern is an ANA fluorescence pattern that is commonly encountered in laboratories. This pattern is largely detected among the healthy population and in non-SARDs patients. Although this pattern is still can be observed among SARDs patients, the low prevalence of monospecific or isolated anti-DFS70 antibodies makes it useful for ruling out AARDs diagnosis...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658525/genetic-alterations-in-prostate-cancer-as-diagnostic-and-prognostic-markers
#35
JOURNAL ARTICLE
H Saeidi, P Ismail, C Samudi Raju, M G Khairul-Asri, I H Bakrin
Prostate cancer is the second-most frequently diagnosed cancer in men worldwide. Serum prostatespecific antigen is currently used for the early detection of prostate cancer. However, new biomarkers are needed to decrease over diagnosis and over treatment of prostate cancer due to limitations of prostate-specific antigen. Recently, molecular biomarkers have shown promising results for diagnosis and prognosis of prostate cancer. Molecular biomarkers have improved the sensitivity and specificity of prostate-specific antigen and studies are ongoing to identify molecular biomarkers as a replacement for prostate-specific antigen...
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37119257/the-characteristically-weak-pax-5-staining-of-reed-sternberg-cells-surrounds-distinct-negatively-stained-block-like-inclusions-in-classic-hodgkin-lymphoma
#36
JOURNAL ARTICLE
https://read.qxmd.com/read/37119256/eosinophilic-t-cell-chorionic-vasculitis
#37
JOURNAL ARTICLE
G C Tan, Y P Wong, R Abd Rahman
No abstract available.
April 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37119255/post-mortem-computed-tomography-differentiation-of-putrefactive-gas-and-air-embolism-a-case-of-traumatic-carotid-jugular-arteriovenous-fistula
#38
JOURNAL ARTICLE
Y L Wong, A N Hamdan, M K Chainchel Singh, S F Siew
INTRODUCTION: PMCT is superior to autopsy for identification of intravascular or extravascular gas pockets and their distribution. However, differentiation between air embolism and putrefactive gas can prove challenging due to overlapping imaging findings. CASE REPORT: We report a case of a healthy young man who was involved in a fight, sustained a slash wound to the right side of his head by a kitchen knife and died at the scene. Pre-autopsy PMCT demonstrated complex fractures of the right mastoid bone extending to the right petrous apex and jugular bulb, exposing the right sigmoid sinus...
April 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37119254/mixed-autoimmune-haemolytic-anaemia-in-a-covid-19-patient
#39
JOURNAL ARTICLE
N Mohd Shukri, N A F A A Ab Aziz
INTRODUCTION: Mixed warm and cold autoimmune haemolytic anaemia (AIHA) secondary to COVID-19 is rarely reported. CASE REPORT: We present a case of a 65-year-old Malay lady with no known medical illness, who was admitted for COVID-19 category 3 and mixed warm and cold AIHA. She presented with lethargy, productive cough and on and off fever. Blood investigations showed severe anaemia with spurious macrocytosis, increased lactate dehydrogenase (LDH) and total bilirubin with indirect bilirubin predominance...
April 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37119253/adamantinoma-like-ewing-sarcoma-of-thyroid-gland-an-unfamiliar-mimicker-of-epithelial-and-mesenchymal-neoplasms-of-the-head-and-neck
#40
JOURNAL ARTICLE
I Mohammed, B Baskovich, A Alkhasawneh, A Gopinath
INTRODUCTION: Adamantinoma-like Ewing Sarcoma (ALES) is a rare variant of the Ewing family of tumours (EFT) harbouring the EWSR1-FLI1 translocation and with complex epithelial differentiation. Very few cases of ALES involving thyroid have been reported in literature. CASE REPORT: We report a case of ALES involving the thyroid in a 61-year-old male who presented with an enlarging nodule in the left lobe of the thyroid and underwent hemithyroidectomy. DISCUSSION: ALES demonstrates morphologic similarity to a multitude of epithelial and mesenchymal tumours, creating a potential diagnostic pitfall in thyroid and head and neck pathology...
April 2023: Malaysian Journal of Pathology
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