journal
https://read.qxmd.com/read/38155391/abstracts-of-the-national-pathology-conference-2023-by-perak-pathology-services-held-at-hotel-casuarina-ipoh-perak-on-2nd-and-3rd-august-2023
#1
JOURNAL ARTICLE
(no author information available yet)
No abstract available.
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155390/abstracts-of-the-international-congress-of-pathology-laboratory-medicine-2023-precision-medicine-revolutionizing-pathology-in-genomic-era-organised-by-the-college-of-pathologists-academy-of-medicine-of-malaysia-and-at-world-trade-centre-kuala-lumpur-on-20-22
#2
JOURNAL ARTICLE
https://read.qxmd.com/read/38155389/the-circulating-cells-with-blast-like-morphology-in-transient-abnormal-myelopoiesis-of-down-syndrome-are-unique-and-deserve-a-specific-name-would-the-term-megakaryogones-serve-this-purpose
#3
JOURNAL ARTICLE
https://read.qxmd.com/read/38155388/gastrointestinal-stromal-tumour-in-a-jejunal-diverticulum-the-eighth-reported-case-worldwide-with-a-brief-review-of-the-literature
#4
REVIEW
S F Chiew, Y F Toh, L M Looi, P L Cheah
Jejunal diverticulosis is uncommon and so are gastrointestinal stromal tumours (GIST) arising in the jejunum. GIST arising in a jejunal diverticulum is a rarity and to date there are only 7 cases in the English literature. Our case of GIST occurring in a jejunal diverticulum of a 48-year-old lady would be the first reported in Malaysia and the 8th in the world. As in most cases, the clinical presentation and radiological findings of this patient were non-specific. With a history of acute abdominal pain, vomiting and fever, the patient was provisionally diagnosed as a case of twisted ovarian cyst and subjected to laparotomy...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155387/cd47-and-cd36-expressions-in-the-placenta-of-mothers-with-chorioamnionitis
#5
JOURNAL ARTICLE
B S Hanim, R A Rahim, M F Mohd Salleh, H Zakaria, N Abd Shukor
INTRODUCTION: Chorioamnionitis is the inflammation of the placenta and is histologically defined as the presence of neutrophilic infiltration into the chorio-amnion membrane with and without involvement of the umbilical cord. Currently, the inflammatory mediators involved in the eliciting of inflammatory response is still largely under investigation. CD47 and CD36 are pro-inflammatory molecules that are still under investigation. The aim of this study was to determine the expressions of CD47 and CD36 in the placenta of mothers with chorioamnionitis...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155386/suction-rectal-biopsy-srb-in-hirschsprung-s-disease-is-a-single-macroscopically-adequate-sample-sufficient
#6
JOURNAL ARTICLE
P K Bal, S A Nah, W M R Wan Mohamad Noor, M T Md Nor, S Singaravel, W S Tan, Y W Tan, A Sanmugam
Hirschsprung's Disease (HD) is a congenital disorder causing severe constipation in infants and children. Suction rectal biopsy (SRB) is the preferred technique for obtaining tissue samples for histopathological evaluation. In low-resource settings like Malaysia, cost-effective diagnostic approaches are necessary, making single sample SRB valuable. This study evaluates the diagnostic accuracy and sufficiency of a single macroscopically adequate sample in suction rectal biopsies for the histopathological confirmation of HD...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155385/epidemiology-of-neonatal-pneumothorax-developed-spontaneously-and-during-respiratory-supports-in-neonatal-intensive-care-units
#7
JOURNAL ARTICLE
N Y Boo, E L Lee Ang, The Malaysian National Neonatal Registry
BACKGROUND: Information on incidence and risk factors associated with different types of neonatal pneumothorax were lacking globally. OBJECTIVES: To determine incidences of pneumothorax developed spontaneously and during different modes of respiratory support, and risk factors associated with each type of pneumothorax. STUDY DESIGN: Retrospective observational study of neonates in the Malaysian National Neonatal Registry. SETTING: 44 Malaysian neonatal intensive care units (NICUs)...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155384/placenta-microrna-profile-of-patient-with-obstetric-antiphospholipid-syndrome
#8
JOURNAL ARTICLE
M A Mohamad, A W Ahmad Asnawi, M S Suhiman, J Sathar, A R Hayati, N S Abdul Rahim, M A Masri, N Abdul Hamid, S Nurul Farihah, N Mohamad Nor, M M Nur Fariha
The onset of obstetric antiphospholipid syndrome (APS) occurs when antiphospholipid antibodies act upon the placenta. During pregnancy, APS exhibits traits such as vascular thrombosis, inflammation, and hindered trophoblast implantation. The involvement of microRNA expression has been proposed as a genetic factor contributing to the syndrome's development. MicroRNAs play a role in regulating gene expression in various cellular processes, including the formation of placental tissue. Therefore, additional research is needed to explore the control of placental miRNA in APS...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155383/antifungal-susceptibility-profile-and-biofilm-producing-capability-of-candida-tropicalis-isolates-in-a-tertiary-medical-centre
#9
JOURNAL ARTICLE
S D Navarathinam, H M Neoh, T L Tan, A A Wahab, M N Mohd Nizam Tzar, C H Ding
BACKGROUND: Candida tropicalis is a globally distributed yeast that has been popping up in the medical literature lately, albeit for unenviable reasons. C. tropicalis is associated with substantial morbidity, mortality as well as drug resistance. The aims of this study were to ascertain the antifungal susceptibility profile and the biofilm-producing capability of this notorious yeast in our centre. METHODS: C. tropicalis isolates from sterile specimens were collected over a 12-month period...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155382/clinicopathological-characteristics-of-myelodysplastic-syndromes-with-del-5q-in-taiwan
#10
JOURNAL ARTICLE
C F Yang, C Y Hsu, L T Hsiao, S W Chen, S S Chuang
BACKGROUND: Myelodysplastic syndromes (MDS) are a group of clonal haematopoietic stem cell disorders characterised by ineffective haematopoiesis and cytopenia. Studies have reported differences in MDS between Asian and Western countries, but data from Taiwan are scarce. MATERIALS AND METHODS: In this study we analysed the clinical and pathological features of 32 Taiwanese MDS patients with del(5q) (ie, del(5q) alone [Group A, n = 11], del(5q) with one additional cytogenetic abnormality other than monosomy 7 or del(7q) [Group B, del(5q)+1; n = 6], and del(5q) with ≥2 additional cytogenetic abnormalities [Group C, n = 15])...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155381/species-specific-pcr-primers-for-simultaneous-detection-of-aspergillus-fumigatus-aspergillus-terreus-candida-albicans-and-candida-glabrata-in-invasive-fungal-infections
#11
JOURNAL ARTICLE
Y K M Ismadi, S Mohamad, A Harun
A rapid and accurate diagnosis of invasive fungal infections (IFIs) has been a great challenge particularly in cases requiring prompt antifungal treatment. In this study, four primer pairs were designed for a quadruplex PCR assay, which was developed for detection of four fungal species simultaneously. DNA extraction of cultured colonies and spiked blood samples were performed using conventional (phenol-chloroform) techniques and commercial DNA extraction kit. The optimum annealing temperature for this assay was 60°C...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155380/reference-intervals-for-ctx-and-p1np-in-a-multi-ethnic-malaysian-cohort
#12
JOURNAL ARTICLE
R Z Tan, S C Thambiah, T P Loh, S Vasikaran, S S Yeap
BACKGROUND: Well defined reference intervals are central to the utility of serum C-terminal telopeptide of type 1 collagen (CTX) and N-terminal propeptide of type I procollagen (P1NP), designated as reference markers in osteoporosis, and useful for monitoring therapeutic response in that condition. This study reports the reference intervals for plasma CTX and serum P1NP in a multi-ethnic Malaysian population. METHODS: Ethnic Malay, Chinese or Indian subjects aged 45-90 years old were recruited from Selangor, Malaysia from June 2016 to August 2018...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155379/a-mutation-panel-comprising-braf-v600e-nras-q61r-and-nras-q61h-replicated-retrospective-histopathological-examination-findings-in-differentiating-benign-goitre-from-malignant-papillary-thyroid-cancer-in-a-cohort-of-malaysian-patients
#13
JOURNAL ARTICLE
Z H Eng, M M Ahmad Jefry, K L Ng, A Abdul Aziz, S Mat Junit
Thyroid malignancy status is usually confirmed through histopathological examination (HPE) following thyroidectomy. In Malaysia, the application of molecular markers in pre-operative diagnosis of thyroid cancer remains unexplored. In this study, BRAF and NRAS gene mutation panel was assessed, and the results were compared with retrospective HPE findings. Malaysian patients with benign goitre (BTG: n=33) and papillary thyroid cancer (PTC: n=25; PTCa: n=20, PTCb: n=5) were recruited at Universiti Malaya Medical Centre from September 2019 to December 2022...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155378/epithelial-mesenchymal-transition-profiles-in-triple-negative-breast-carcinoma-may-explain-its-aggressive-nature
#14
JOURNAL ARTICLE
S F Chiew, L M Looi, P L Cheah, K H Teoh, S W Chang, S F Abdul Sani
Epithelial-mesenchymal transition (EMT) is increasingly explored in cancer progression. Considering that triple negative (TN) breast cancer has the poorest survival among molecular subtypes, we investigated 49 TN, 45 luminal and 25 HER2-enriched female breast carcinomas for EMT expression (using E-cadherin and vimentin immunohistochemistry) against lymphovascular and/or lymph node invasion. E-cadherin and vimentin expressions were semi-quantitated for positive- cancer cells (0=0-<1%, 1=1-10%, 2 =11-50%, 3=>50%) and staining intensity (0=negative, 1=weak, 2=moderate, 3=strong), with final score (low=0-4 and high=6-9) derived by multiplying percentage and intensity scores for each marker...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155377/microrna-profiling-in-complete-and-partial-hydatidiform-moles
#15
JOURNAL ARTICLE
W K Chia, H X Y Yeoh, M Mustangin, T Y Khong, Y P Wong, G C Tan
INTRODUCTION: Hydatidiform mole is one of the gestational trophoblastic disease and comprises complete (CM) and partial moles (PM), which carries a risk of developing persistence disease, invasive mole or choriocarcinoma. MicroRNAs (miRNAs) have been discovered in various tissues, including neoplastic tissues. Its role in the pathogenesis of molar pregnancy or as biomarkers are still largely uncertain. The aim of this study is to identify the differentially expressed miRNAs in CM and PM...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155376/urolithiasis-history-epidemiology-aetiologic-factors-and-management
#16
REVIEW
R Kachkoul, G B Touimi, G El Mouhri, R El Habbani, M Mohim, A Lahrichi
Urolithiasis is defined as a disease diagnosed by the presence of one or more stones in the urinary tract. It is one of the oldest and most widespread diseases known to man, their discovery and characterisation chronology began with the civilisation's history. This pathology has a multifactorial aetiology, very frequent worldwide with geographic and racial variation, their prevalence is increasing in lockstep with socioeconomic development. In fact, this disorder affects between 2 and 20% of the population, with an approximate recurrence rate of 30% to 50% in 5 years...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155375/biomarkers-for-colorectal-cancer-chemotherapy-recent-updates-and-future-perspective
#17
REVIEW
P Y Lee, F S Md Azhan, T Y Low
During the last few decades, the treatment options available for patients with metastatic colorectal cancer (mCRC) have undergone continuous improvements, transitioning from conventional chemotherapy to targeted therapy. These therapeutic innovations have led to significant improvements in patient clinical outcomes. However, there remains a need to improve the outcome for many CRC patients. Chemotherapy remains a cornerstone of CRC treatment, but the wide variability in tumour response and adverse reactions to chemotherapy poses a challenge to cancer treatment management...
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/38155374/mjp-going-green
#18
JOURNAL ARTICLE
G C Tan, S K Cheong
No abstract available.
December 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658541/abstracts-of-the-13th-asia-pacific-international-academy-of-pathology-congress-2023-held-16th-to-18th-june-2023
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract available.
August 2023: Malaysian Journal of Pathology
https://read.qxmd.com/read/37658540/early-t-cell-precursor-lymphoblastic-leukaemia-with-monocytic-morphology-negative-for-cd3-by-flow-cytometry-a-diagnostic-challenge-solved-by-immunohistochemistry
#20
JOURNAL ARTICLE
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