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Malaysian Journal of Pathology

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https://www.readbyqxmd.com/read/29704390/abstracts-of-the-16th-annual-scientific-meeting-of-the-college-of-pathologists-academy-of-medicine-of-malaysia
#1
(no author information available yet)
No abstract available.
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704389/recommended-parameters-for-pathology-reporting-of-gastroenteropancreatic-neuroendocrine-tumours-gep-nets
#2
(no author information available yet)
No abstract available.
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704388/unrecognised-igg4-association-in-progressively-transformed-germinal-centers-of-lymph-nodes-with-subsequent-full-blown-igg4-related-chronic-fibrosing-pancreatitis-a-case-report
#3
H J Son, H Lee, J H Kim, I K Yu, H Y Han
Progressively transformed germinal centers (PTGC) is a benign process characterised by a morphological variant of reactive follicular hyperplasia in lymph nodes. It was recently shown that some cases of PTGC are associated with IgG4-related disease (IgG4-RD) or increased IgG4 plasma cells. Five years ago, a 57-year-old woman presented with enlargement of multiple lymph nodes in the left parotid, submandibular, and neck areas, pathologically diagnosed as PTGC after excisional biopsy. Since then, she has experienced numbness in her extremities, especially the left shoulder and arm, pruritus on the left side of the face and intermittent facial palsy, for which she has been receiving regular symptomatic treatment...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704387/the-crucial-role-of-molecular-testing-to-facilitate-the-diagnosis-of-pneumocystis-pneumonia-during-pregnancy
#4
C H Ding, H Yusoff, N A S Muttaqillah, Y L Tang, T L Tan, P Periyasamy, A Y L Ban
Pneumocystis pneumonia is an important human immunodeficiency virus (HIV)-associated opportunistic infection, and especially so in pregnant HIV-positive patients. We report a case of a 40-year-old woman in her first trimester of pregnancy who initially presented with acute gastroenteritis symptoms but due to a history of high-risk behaviour and the observation of oral thrush, she was worked up for HIV infection. Her retroviral status was positive and her CD4+ T cell count was only 8 cells/┬ÁL. She was also worked up for pneumocystis pneumonia due to the presence of mild resting tachypnoea and a notable drop in oxygen saturation (from 100% to 88%) following brief ambulation...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704386/autologous-mononuclear-cells-from-different-sources-are-seen-to-improve-wound-healing-in-patients-with-haematological-malignancies
#5
W F Wan Jamaludin, F Mohamad Yusoff, N A Ismail, M R Mohd Idris, S Palaniappan, C K K Ng, N Abdullah, S Z A Zaider, S F S Abdul Wahid
INTRODUCTION: Immunosuppressive state due to haematological malignancies and chemotherapy may cause disruption to wound healing despite optimum conventional treatment and standard wound dressing. Non-healing wounds are predisposed to infection whereas chemotherapy dose reductions or interruptions are associated with poor survival. BACKGROUND: Mononuclear cells contain progenitor cells including haematopoietic and mesenchymal stem cells, endothelial progenitor cells and fibroblasts which facilitate wound healing through cytokines, growth factor secretions, cell-cell interactions and provision of extracellular matrix scaffolding...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704385/cd10-expression-pattern-in-prostatic-adenocarcinoma-elucidation-of-differences-between-gleason-s-grades
#6
M Kaur, S Verma, R Gupta, L Pant, S Singh
CD10, a transmembrane endopeptidase, has been shown to be lost as an early event in prostate cancer. We aimed at evaluating the pattern of expression of CD10 in various Gleason's grades of prostatic adenocarcinoma in comparison with nodular hyperplasia of prostate. This retrospective study included 30 cases of nodular hyperplasia and 30 of prostatic adenocarcinoma of various Gleason's grades. Immunohistochemical staining for CD10 was performed on all cases and positivity evaluated as percentage of cells as well as location (membranous or cytoplasmic or both)...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704384/epstein-barr-virus-infection-in-b-cell-non-hodgkin-s-lymphomas-of-the-oral-and-maxillofacial-region-is-there-any-evidence
#7
L M Abdelrahim, S C Peh, T G Kallarakkal
INTRODUCTION: Epstein-Barr virus (EBV) might be an aetiological agent involved in the pathogenesis of certain Non-Hodgkin's Lymphomas (NHLs). EBV infection has been diagnosed by serologic testing within the tumour biopsies of patients with NHL. However, the association between EBV and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the oral cavity and maxillofacial region using histological and immunophenotypical techniques and to determine its association with EBV infection...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704383/plasma-derived-microparticles-in-polycythaemia-vera
#8
M Ahadon, S Abdul Aziz, C L Wong, C F Leong
INTRODUCTION: Microparticles are membrane bound vesicles, measuring less than 1.0 um, which are released during cellular activation or during apoptosis. Studies have shown that these circulating microparticles play a role in coagulation, cell signaling and cellular interactions. Increased levels of circulating microparticles have been observed in a number of conditions where there is vascular dysfunction, thrombosis and inflammation. The objective of this study was to determine the various plasma-derived microparticles in patients with polycythaemia vera (PV) in Universiti Kebangsaan Malaysia Medical Centre and to compare them with normal control...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704382/establishing-the-cut-off-values-of-androgen-markers-in-the-assessment-of-polycystic-ovarian-syndrome
#9
R N D Nadaraja, P Sthaneshwar, N Razali
INTRODUCTION: Hyperandrogenism remains as one of the key features in Polycystic Ovarian Syndrome (PCOS) and can be assessed clinically or determined by biochemical assays. Hirsutism is the most common clinical manifestation of hyperandrogenism. The clinical assessment is subjected to wide variability due to poor interobserver agreement and multiple population factors such as ethnic variation, cosmetic procedures and genetic trait. The difficulty in resolving the androgen excess biochemically is due to a lack of consensus as to which serum androgen should be measured for the diagnosis of PCOS...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704381/study-on-abo-and-rhd-blood-grouping-comparison-between-conventional-tile-method-and-a-new-solid-phase-method-intec-blood-grouping-test-kit
#10
R Yousuf, S A Abdul Ghani, N Abdul Khalid, C F Leong
INTRODUCTION: 'InTec Blood Grouping Test kit' using solid-phase technology is a new method which may be used at outdoor blood donation site or at bed side as an alternative to the conventional tile method in view of its stability at room temperature and fulfilled the criteria as point of care test. This study aimed to compare the efficiency of this solid phase method (InTec Blood Grouping Test Kit) with the conventional tile method in determining the ABO and RhD blood group of healthy donors...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704380/the-spectrum-of-pathological-findings-of-tonsils-in-children-a-clinicopathological-review
#11
G C Tan, M Stalling, S Al-Rawabdeh, B M Kahwash, R F Alkhoury, S B Kahwash
Tonsillectomy is among the most commonly performed operations in children. Although follicular lymphoid hyperplasia is usually the main and only pathologic finding at microscopic examination, a variety of other rare but important pathologic changes may be encountered. This review aims to provide an inclusive practical resource and reference for both training and practising pathologists. It discusses the spectrum of pathologic findings, including both neoplastic and non-neoplastic conditions and provides illustrative images...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29704379/mechanical-profiles-of-murder-and-murderers-an-extensive-review
#12
M R Kamaluddin, N S Md Shariff, G A Mat Saat
INTRODUCTION: Murder is an extreme form of violent crime which occurs across all social, cultural, and ethnic spheres. It is therefore, crucial to understand the nature and the extent of mechanical profiles of murder and murderers. The purpose of this article is to review such critical aspects of murder in a nutshell. METHODS: An archival research methodology was employed in this study where relevant search for literatures on these mechanical aspects related to murder was made across search engines such as Google Scholar and Elsevier with relevant articles selected for this review...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279600/abstracts-of-the-2017-4th-annual-scientific-meeting-of-the-malaysian-division-of-the-international-academy-of-pathology
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279599/solid-pseudopapillary-neoplasm-of-the-pancreas-with-liver-metastasis-initially-misinterpreted-as-benign-haemorrhagic-cyst
#14
M J Jung, H K Kim, S Y Choi, S G Kim, S Y Jin
Solid pseudopapillary neoplasm (SPN) of the pancreas is considered a low-malignant neoplasm with a good prognosis. However, 5% to 15% of patients with SPNs develop metastatic disease, most commonly in the liver. Metastatic hepatic malignancies that show pseudocystic features are rare. Here we describe the case of a middle-aged female with a cystic liver metastasis from SPN. To the best of our knowledge, SPN with a single cystic liver metastasis has not been described, although these tumours frequently undergo haemorrhagic-cystic degeneration...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279598/secondary-polycythaemia-in-a-malay-girl-with-homozygous-hb-tak
#15
H S Amran, M A Aziz, E George, N Mahmud, T Y Lee, S Md Noor
Hb Tak is one of more than 200 high affinity haemoglobin variants reported worldwide. It results from the insertion of two nucleotides (AC) at the termination codon, between codon 146 and codon 147 of the beta-globin gene [Beta 147 (+AC)]. Polycythaemia is the main clinical feature although affected carriers are usually asymptomatic and do not require intervention. Several case studies in this region have reported the co-inheritance of Hb Tak with Hb E, delta beta and beta thalassaemia with one case of homozygous Hb Tak in a Thai boy...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279597/severe-asymptomatic-hypophosphataemia-in-a-child-with-t-acute-lymphoblastic-leukaemia
#16
N H Zakaria, P Sthaneshwar, H Shanmugam
Hypophosphataemia is a metabolic disorder that is commonly encountered in critically ill patients. Phosphate has many roles in physiological functions, thus the depletion of serum phosphate could lead to impairment in multiple organ systems, which include the respiratory, cardiovascular, neurological and muscular systems and haematological and metabolic functions. Hypophosphataemia is defined as plasma phosphate level below 0.80 mmol per litre (mmol/L) and can be further divided into subgroups of mild (plasma phosphate of 0...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279596/light-chain-multiple-myeloma-an-evaluation-of-its-biochemical-investigations
#17
S Y Zahari Sham, S C Thambiah, I N Samsudin, S M Lim
Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM) makes up almost 20% of myelomas. Clinical manifestation is often heralded by hypercalcaemia, renal impairment, normocytic normochromic anaemia and bone lesions, reflecting end-organ damage, collectively known as the acronym CRAB...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279595/pseudomyogenic-epithelioid-sarcoma-like-hemangioendothelioma-a-rare-vascular-neoplasm-with-deceptive-morphology-and-distinctive-immunophenotype
#18
F F Cheo, K Sittampalam
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a rare, low grade vascular (endothelial) neoplasm typically presenting as multicentric, superficial to deep nodules in extremities with a slight tendency of affecting young adult males. We report a case of pseudomyogenic hemangioendothelioma in a 15-year-old boy presenting initially with a 1 cm right thigh painless cutaneous lump. The lump was excised with the clinical impression of a sebaceous cyst. On microscopy, a poorly circumscribed, mild to moderately atypical spindle cell lesion in fascicular and storiform patterns with strikingly myoid-like eosinophilic cytoplasm was identified...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279594/poems-syndrome
#19
W W T Nyunt, R Remli, F A Abdul Muttlib, C F Leong, N Masir, N R Tumian, S F S Abdul Wahid
POEMS syndrome is the syndrome of Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and typical Skin changes. A 65-year-old lady presented with the 2-day-history of inability to walk, 4-month-history of progressive worsening of muscle weakness of both lower limbs and 1-year-history of progressive worsening of bilateral numbness of lower limbs. Nerve conduction study revealed generalized sensorimotor demyelinating polyneuropathy. She was initially treated as chronic inflammatory demyelinating polyradiculoneuropathy with intravenous immunoglobulin (IVIG) and high-dose prednisolone...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29279593/diagnostic-conundrum-of-a-perineal-tumour-a-rectal-gastrointestinal-stromal-tumour-mimic
#20
R Shi, M H Chew, W Q Leow
Gastrointestinal stromal tumour (GIST) is a common mesenchymal tumour arising in the gastrointestinal tract, but not frequently encountered in the rectum. Herein, we describe a case of a rectal GIST which mimicked histomorphological features of a schwannoma; thus, making intraoperative frozen section evaluation challenging. Although subsequent immunohistochemistry and molecular findings readily confirmed the diagnosis of a GIST, we wish to draw attention to three clues that will help the pathologist steer clear of this potential diagnostic pitfall...
December 2017: Malaysian Journal of Pathology
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