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Malaysian Journal of Pathology

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https://www.readbyqxmd.com/read/28866707/a-linking-bridge-between-histopathological-analysis-and-molecular-assay-in-microbiology
#1
Y Okubo
No abstract available.
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866706/extensive-left-ventricular-pulmonary-artery-and-pericardial-metastasis-from-myxoid-liposarcoma-16-years-after-the-initial-detection-of-the-primary-tumour-a-case-report-and-review-of-the-literature
#2
D Motevalli, S M Tavangar
Liposarcoma is regarded as the second most common soft tissue malignant tumour. Metastasis of liposarcoma to the heart is very rare, and to date, less than 40 cases have been reported in the literature. We report a 46 year-old male with myxoid liposarcoma of the lower extremity who developed extensive metastasis to the left ventricle, pulmonary artery, and pericardium. The patient presented with acute symptoms of dyspnea 16 years after surgical resection of the primary tumour, and his dyspnea progressed to cardio-respiratory arrest within the first few days of hospital admission...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866705/familial-antithrombin-iii-deficiency-in-a-malay-patient-with-massive-thrombosis
#3
W S Wan Ab Rahman, W Z Abdullah, M N Hassan, A Hussin, Z Zulkafli, J Haron
Patients with low antithrombin III (AT III) has increased risk for arteriovenous thromboembolic (TE) disease. We report a 28-year-old Malay lady who presented with spontaneous right calf pain and swelling of one week duration. She was on oral contraceptive pills and had a history of travelling for a long distance prior to the presentation. Her brother who was diagnosed with AT III deficiency had arterial thrombosis at a young age. She was diagnosed as having right popliteal vein thrombosis by ultrasound and treated with subcutaneous fondaparinux...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866704/unexpected-infant-death-secondary-to-a-pulmonary-infiltration-due-to-acute-myelocytic-leukaemia
#4
M Ben Khelil, Y Chkirbene, M Mlika, S Haouet, M Hamdoun
Acute myeloid leukaemia (AML) often presents with non-specific symptoms such as fatigue, anaemia or infection. Pulmonary involvement is uncommon in AML during the course of the disease and is usually caused by infection, haemorrhage, leukaemic pulmonary infiltrates and leukostasis. Lung localization of AML is very uncommon and potentially life threatening if not diagnosed and treated rapidly. The authors describe the sudden death of an asymptomatic five-month-infant because of a misdiagnosed lung localization of AML...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866703/clinical-judgement-perplexed-by-initially-undisclosed-use-of-herbal-medicine-and-unexpected-cross-reactivity-of-immunoassay
#5
K T Liu, C W Lee
We report a case of symptomatic bradycardia caused by consumption of a Chinese herbal medicine which was initially undisclosed to the attending emergency physician. The scientific name of the herb is Panax japonicus. Electrocardiogram revealed sinus bradycardia. Laboratory tests were normal except for the detection of a high serum digoxin level. Further interrogation of the patient eventually disclosed ingestion of the herb which, however, did not contain any digoxin. Other active ingredients in the herb include various types of ginsenoside...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866702/a-fatal-gastric-perforation-secondary-to-ulcerated-metastasis-in-undiagnosed-breast-cancer-pathological-aspects-and-review-of-literature
#6
R Barranco, G F Orcioni, F Ventura
The authors describe a fatal case of gastric perforation secondary to an ulcerated metastasis in a woman with undiagnosed breast cancer. The 48-year-old woman, with no significant medical history, presented with weight loss, persistent dyspepsia and pain in the epigastric and mesogastric region. She was treated by her primary care physician with proton-pump inhibitors and antispasmodics. The following day she was found dead at her home. External examination showed a tumefaction in the lateral region of her left breast, near the axilla...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866701/p40-in-metastatic-pulmonary-trophoblastic-tumour-potential-diagnostic-pitfall-on-histopathology
#7
A G Vallonthaiel, R Walia, R Pramanik, M C Sharma, D Jain
p40, one of the two isomers of p63, is nowadays widely used for diagnosis of squamous cell carcinoma, especially in subtyping non-small cell carcinoma on lung biopsies. We describe a case in which lung tumour was misdiagnosed as squamous cell carcinoma due to p40 immunopositivity. A 36-year-old lady presented with cough and left sided chest pain of 2 months duration. Chest imaging revealed a lesion in left lower lobe of the lung and biopsy was suggestive of squamous cell carcinoma. However, past history revealed amputation of great toe for non-healing discharging ulcer which on histopathology was diagnosed as choriocarcinoma...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866700/synchronous-papillary-thyroid-carcinoma-and-medullary-thyroid-carcinoma-a-pitfall-waiting-to-happen
#8
P Y Tang, L Y Khor, A Takano
Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells. Synchronous occurrence of these two carcinomas is uncommon and occurs as either discrete lesions or as a mixed lesion. The current case report describes a 50-year-old woman with synchronous multiple discrete MTC and PTC with lymph nodes metastasis. Pathologists and treating physicians should be aware of the synchronous coexistence of these entities to avoid possible misdiagnosis...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866699/a-sudden-paediatric-death-due-to-hand-foot-and-mouth-disease-the-importance-of-vigilance
#9
R Rahimi, E Omar, T S Tuan Soh, S F A Mohd Nawi, S Md Noor
BACKGROUND: Hand, foot and mouth disease (HFMD) is caused by enteroviruses such as Coxsackie virus A16 (CVA16) and Enterovirus 71 (EV71). The diagnostic hallmarks are oral ulcers and maculo-papular or vesicular rash on the hands and feet. Severe form of this disease can lead to death due to neurological and cardiopulmonary complications. This case report aims to describe a fatal case of HFMD with minimal oral and skin manifestations. CASE REPORT: A four-year-old girl was brought to a hospital after suddenly becoming unresponsive at home...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866698/isolation-by-culture-and-pcr-identification-of-lipl32-gene-of-pathogenic-leptospira-spp-in-wild-rats-of-kuala-lumpur
#10
I Latifah, A Abdul Halim, M S Rahmat, M F Nadia, Z E Ubil, H Asmah, I Shafariatul Akmar, M Picardeau, O Siti Haslina, M A Nasir
BACKGROUND: A study was conducted to confirm the status of rats as the carrier of pathogenic leptospira in Kuala Lumpur, Malaysia. METHOD: A total of 140 urine samples were collected from trapped rats. These samples were cultured in EMJH enriched media and 18 of these samples (12.9%) were found to be positive when observed under x40 by dark field microscope. Genomic DNA was extracted from all the 18 native isolates for PCR. RESULT: All the 18 isolates generated the expected 786 base pair band when the set of primers known to amplify LipL32 gene were utilized...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866697/haematological-parameters-and-screening-tests-of-haemostasis-in-children-with-sepsis-results-from-a-tertiary-care-centre-in-india
#11
A Sharma, M Sikka, H Bhankar, S Gomber, S Sharma
Sepsis is a common cause of death in infants and children. Haemostatic abnormalities have been reported in such patients. There is scant information on the nature and frequency of these abnormalities in children especially from India. Our aim was to evaluate the nature and frequency of haematological and haemostatic abnormalities in children with sepsis. Fifty children between 1-10 years of age admitted with sepsis and 50 age-matched, healthy controls were included in the study. Complete blood counts, examination of stained peripheral blood film, prothrombin time (PT), activated partial thromboplastin time (APTT), plasma fibrinogen, C-reactive protein, liver function tests and serum creatinine were done in all patients and controls...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866696/multiplex-real-time-rt-pcr-assay-for-transfusion-transmitted-viruses-in-sero-negative-allogeneic-blood-donors-an-experience-from-southern-pakistan
#12
S Sultan, M I Nasir, S Rafiq, M A Baig, S Akbani, S M Irfan
BACKGROUND: Blood transfusion safety commences with healthy donor recruitment. The threat of transfusion transmitted infections is greatly minimized by serological tools but not entirely eliminated. Recently, nucleic-acid testing for blood donor screening has virtually eliminated this jeopardy. METHODS: This prospective study was conducted from February 2015 to February 2016. Samples from seronegative donors were run on multiplex assay (Cobas, S-201 system platform, Roche) in a batch of six [MP-NAT]...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866695/the-value-of-nottingham-grade-in-breast-cancer-re-visited-in-the-sri-lankan-setting
#13
H Peiris, L Mudduwa, N Thalagala, K Jayatialake
OBJECTIVE: We aimed to assess the impact of Nottingham grade (NG) on breast cancer specific survival (BCSS) and recurrence free survival (RFS) of operable breast cancer (BC) patients presenting at different TNM stages in view of assessing the value of NG in prognostication of breast cancer in the Sri Lankan setting. METHOD: This retro-prospective study included a consecutive series of TNM stage I to III BC patients presented to our unit from 2006 to 2012. Data were collected through follow up visits, clinic and laboratory records...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866694/determination-of-the-99th-percentile-upper-reference-limit-for-high-sensitivity-cardiac-troponin-i-in-malaysian-population
#14
S M Lim, S C Thambiah, S Y Zahari Sham, R Omar, Z Hambali, I N Samsudin
Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in Malaysia requires determination of the 99(th) percentile upper reference limit (URL) for each assay to suit local context. Hence, this study aimed to determine the 99(th) percentile URL for hscTn I in the Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott Diagnostics hscTn I assay on Architect i2000sr analyser...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866693/a-15-year-single-centre-retrospective-study-of-antiphospholipid-syndrome-patients-from-northern-malaysia
#15
M A Islam, F Alam, S H Gan, T H Sasongko, W S Wan Ghazali, K K Wong
BACKGROUND: Antiphospholipid syndrome (APS) is an autoimmune disorder characterised by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPLs) based on the Sydney criteria. We aimed to explore the clinico-laboratory features and treatment strategies of APS patients retrospectively. METHODOLOGY: The medical records of APS patients registered under Hospital Universiti Sains Malaysia (Kelantan state) between 2000 and 2015 were reviewed...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866692/frequency-and-molecular-epidemiology-of-panton-valentine-leukocidin-gene-in-staphylococcus-aureus-colonising-hiv-infected-patients
#16
Z Mohd-Zain, S F A Mohd-Nawi, A Adnan, S Kumar
BACKGROUND: HIV-infected patients pose a high risk of contracting skin and soft tissue infections caused by Staphylococcus aureus. Those who are colonized with methicillin-resistant S. aureus (MRSA) that carry Panton-Valentine leukocidin (PVL) are predisposed to severe infections that could lead to necrotic skin infections. However the association of S. aureus specifically methicillin sensitive S. aureus carrying PVL gene in HIV patients has not been widely reported. Here, we study the prevalence and the molecular epidemiology of PVL-producing S...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866691/primary-imatinib-resistance-in-chronic-myeloid-leukemia-patients-in-a-developing-country-bcr-abl-kinase-domain-mutations-or-bcr-abl-independent-mechanisms
#17
E Yap, N R Tumian, R Z Azma, N A Sharifah, S Salwati, N H Hamidah, M H Elias, C L Wong
Clinical resistance to imatinib (IM) in chronic myeloid leukemia (CML) carries adverse consequences. We investigated 22 CML patients who developed IM-resistance for BCR-ABL kinase domain (KD) mutations. The median follow-up for this study was 101.9 months (range: 22.2 to 176.5 months) and the estimated mean overall survival was 150.87 months (95% CI: 130.0 to 171.0). Five out of 22 patients tested positive for BCR-ABL KD mutations: 2 had T315I, 2 had E255K and 1 had V289F mutations. Of the remaining 17 patients who did not harbor BCR-ABL KD mutations, 11 patients received nilotinib while the rest continued on IM...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28866690/molecular-analysis-of-fragile-x-syndrome-fxs-among-malaysian-patients-with-developmental-disability
#18
E Z Ali, Y Yakob, N Md Desa, T Ishak, Z Zakaria, L K Ngu, W T Keng
Fragile X syndrome (FXS) is a neurodevelopmental disorder commonly found worldwide, caused by the silencing of fragile X mental retardation 1 (FMR1) gene on the X-chromosome. Most of the patients lost FMR1 function due to an expansion of cytosine-guanine-guanine (CGG) repeat at the 5' untranslated region (5'UTR) of the gene. The purpose of this study is to identify the prevalence of FXS and characterize the FMR1 gene CGG repeats distribution among children with developmental disability in Malaysia. Genomic DNA of 2201 samples from different ethnicities (Malays, Chinese, Indian and others) of both genders were PCR-amplified from peripheral blood leukocytes based on specific primers at 5'UTR of FMR1 gene...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413213/response-prevalence-of-braf-v600e-mutation-in-asian-patients-with-thyroid-cancer
#19
C G Navarro-Locsin
No abstract available.
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413212/prevalence-of-braf-v600e-mutation-in-asian-patients-with-thyroid-cancer
#20
A Bychkov
No abstract available.
April 2017: Malaysian Journal of Pathology
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