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Malaysian Journal of Pathology

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https://www.readbyqxmd.com/read/28413213/response-prevalence-of-braf-v600e-mutation-in-asian-patients-with-thyroid-cancer
#1
C G Navarro-Locsin
No abstract available.
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413212/prevalence-of-braf-v600e-mutation-in-asian-patients-with-thyroid-cancer
#2
A Bychkov
No abstract available.
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413211/vaginal-brenner-tumor-with-literature-review-does-this-tumour-originate-from-walthard-nests
#3
S Park, M S Cho
Vaginal Brenner tumor is extremely rare. Only five cases have been reported in the English literature to date. Here we report a vaginal Brenner tumor in a 76-year old postmenopausal woman, who presented with a 2.5cm-sized sessile vaginal polyp. Microscopically, it showed characteristic features of Brenner tumor consisting of three components; transitional islands, glands, and dense fibrous stroma. The epithelial tumor cells were positive for GATA-3, p63 and ER, but negative for PAX8. The origin of Brenner tumors in the vagina is unclear, but previous reports suggested of Müllerian origin...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413210/acute-pulmonary-thromboembolism-in-a-case-of-fatal-child-abuse
#4
R Rahimi, Z F Zulkifli, E Omar, H Ismail, S Md Noor
Child abuse is a worldwide problem. The four major types of abuse include physical abuse, child neglect, psychological maltreatment and sexual violence. We describe a fatal case of child abuse which presented with numerous old and recent soft tissue injuries all over the body. The injuries on the legs have immobilized the victim for quite some time, giving rise to deep vein thrombosis, leading to death as a result of acute pulmonary thromboembolism. This case demonstrates presence of both elements of abuse and neglect in one victim...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413209/duplication-17p11-2-potocki-lupski-syndrome-in-a-child-with-developmental-delay
#5
S Shuib, N N Saaid, Z Zakaria, J Ismail, Z Abdul Latiff
Potocki-Lupski syndrome (PTLS), also known as duplication 17p11.2 syndrome, trisomy 17p11.2 or dup(17)(p11.2p11.2) syndrome, is a developmental disorder and a rare contiguous gene syndrome affecting 1 in 20,000 live births. Among the key features of such patients are autism spectrum disorder, learning disabilities, developmental delay, attention-deficit disorder, infantile hypotonia and cardiovascular abnormalities. Previous studies using microarray identified variations in the size and extent of the duplicated region of chromosome 17p11...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413208/anti-m-induced-severe-haemolytic-disease-of-foetus-and-newborn-in-a-malay-woman-with-recurrent-pregnancy-loss
#6
H Mohd Nazri, M N Noor Haslina, M Y Shafini, A R Noor Shaidatul Akmal, M Rapiaah, A Wan Zaidah
Haemolytic disease of the foetus and newborn (HDFN) is caused by maternal red blood cells (RBC) alloimmunisation resulted from incompatibility of maternal and foetal RBCs. However, only a few HDFN attributed to anti-M were reported, varying from asymptomatic to severe anaemia with hydrops foetalis and even intrauterine death. A case of severe HDFN due to anti-M alloantibody from an alloimmunized grandmultiparous Malay woman with recurrent pregnancy loss is reported here. The newborn was delivered with severe and prolonged anaemia which required frequent RBC transfusions, intensive phototherapy and intravenous immunoglobulin administration...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413207/rate-of-active-helicobacter-pylori-infection-among-symptomatic-patients-of-pakistan
#7
F Rasheed, A Yameen, T Ahmad, R Bilal
Only few epidemiological studies have examined the rate of active H. pylori infection in the symptomatic population in Pakistan. This retrospective study presents the laboratory data collected during the past 13 years (2002 to 2015) from 2315 symptomatic patients referred to the BreathMAT Lab, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad for the diagnosis of active H. pylori infection using the (13)C Urea Breath Test. Rate of infection and its association with gender and age were evaluated...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413206/differential-diagnostic-significance-of-hbme-1-ck19-and-s100-in-various-thyroid-lesions
#8
S Palo, D S Biligi
OBJECTIVE: Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions. MATERIALS AND METHODS: Immunohistochemical analysis of 60 thyroidectomy specimens (10 hyperplastic nodules, 14 follicular adenomas and 36 malignant thyroid neoplasms) was carried out...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413205/oral-ketamine-induced-pathological-changes-of-the-urinary-tract-in-a-rat-model
#9
R Rajandram, N Y Yap, T A Ong, K S Mun, H A Mohamad Wali, M S Hasan, A H A Razack, M Ali Mohd
INTRODUCTION: In recent years, prolonged ketamine abuse has been reported to cause urinary tract damage. However, there is little information on the pathological effects of ketamine from oral administration. We aimed to study the effects of oral ketamine on the urinary tract and the reversibility of these changes after cessation of ketamine intake. METHODS: Rats were fed with illicit (a concoction of street ketamine) ketamine in doses of 100 (N=12), or 300 mg/kg (N=12) for four weeks...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413204/the-study-of-the-circannual-relationship-between-the-activity-of-the-epiphysis-and-gonads-in-rats-of-different-sex-and-age
#10
N Kononenko, V Hnatiuk
The relationship between the activity of the epiphysis and gonads in rats of different sex and age in different seasons of the year was determined by studying the levels of melatonin and testosterone in the blood plasma. Determination of the levels of melatonin and testosterone in the serum of rats was carried out by enzyme-linked immunosorbent assay. To assess the relationship between the levels of melatonin and testosterone the correlation coefficient was calculated. Based on the study of the levels of melatonin and testosterone in serum the circannual relationship between the activity of the pineal gland and gonads in males of reproductive age has been determined...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413203/nuclear-morphometry-and-texture-analysis-on-cytological-smears-of-thyroid-neoplasms-a-study-of-50-cases
#11
L Deka, S Gupta, R Gupta, K Gupta, C J Kaur, S Singh S
BACKGROUND: Fine needle aspiration cytology (FNAC) is a reliable and reproducible diagnostic technique for thyroid lesions with certain limitations. Computed morphometric methods have been introduced with a view to improve the diagnostic yield of thyroid aspirates. However, a review of the existing literature revealed conflicting reports regarding morphometric parameters in thyroid neoplasms. MATERIALS AND METHODS: This study included 50 cases of thyroid lesions (20 cases of colloid goitre, 15 of follicular adenoma, 5 of follicular carcinoma and 10 papillary carcinomas)...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413202/conventional-versus-molecular-detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-among-males-in-a-sexually-transmitted-infections-clinic
#12
S F Situ, C H Ding, S Nawi, A Johar, R Ramli
BACKGROUND: Chlamydia trachomatis and Neisseria gonorrhoeae are important bacterial pathogens of sexually transmitted infections (STIs) worldwide. This study sought to compare the analytical sensitivity and specificity of conventional methods against a rapid molecular method in detecting STIs caused by these bacteria. METHODS: Ninety five first-time male attendees of the Genito-urinary Medicine Clinic in Hospital Kuala Lumpur were included in this cross-sectional study...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413201/detection-of-%C3%AE-thalassaemia-in-neonates-on-cord-blood-and-dried-blood-spot-samples-by-capillary-electrophoresis
#13
H Alauddin, M Langa, M Mohd Yusoff, R Z A Raja Sabudin, A Ithnin, N F Abdul Razak, N H Sardi, N H Hussin
INTRODUCTION: Haemoglobin Bart's (Hb Bart's) level is associated with α-thalassaemia traits in neonates, enabling early diagnosis of α-thalassaemia. The study aimed to detect and quantify the Hb Bart's using Cord Blood (CB) and CE Neonat Fast Hb (NF) progammes on fresh and dried blood spot (DBS) specimen respectively by capillary electrophoresis (CE). METHODS: Capillarys Hemoglobin (E) Kit (for CB) and Capillarys Neonat Hb Kit (for NF) were used to detect and quantify Hb Bart's by CE in fresh cord blood and dried blood spot (DBS) specimens respectively...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413200/the-oral-microbiome-community-variations-associated-with-normal-potentially-malignant-disorders-and-malignant-lesions-of-the-oral-cavity
#14
S F Mok, C Karuthan, Y K Cheah, W C Ngeow, Z Rosnah, S F Yap, H K A Ong
The human oral microbiome has been known to show strong association with various oral diseases including oral cancer. This study attempts to characterize the community variations between normal, oral potentially malignant disorders (OPMD) and cancer associated microbiota using 16S rDNA sequencing. Swab samples were collected from three groups (normal, OPMD and oral cancer) with nine subjects from each group. Bacteria genomic DNA was isolated in which full length 16S rDNA were amplified and used for cloned library sequencing...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028306/abstracts-of-the-2016-3rd-annual-scientific-meeting-of-malaysian-division-of-the-international-academy-of-pathology
#15
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028305/rare-post-operative-complications-in-a-previously-undiagnosed-congenital-factor-x-deficiency-patient
#16
H Mohd Nazri, A A Suhair, W A R Wan Suriana, Z Zefarina, H Azlan, A Wan Zaidah
Factor X (FX) deficiency is a rare autosomal recessive congenital bleeding disorder. The clinical presentation is among the most severe among the rare coagulation defects. Thus, majority of diagnosed patients will receive factor replacement therapy before surgical manipulation. However, the diagnosis of FX deficiency may be overlooked because it is a rare entity. This is a case report of a 15-year-old male patient who was diagnosed with FX deficiency after developing post-operative complications. With regular fresh frozen plasma infusion given, the patient responded well and recovered...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028304/zollinger-ellison-syndrome-an-unusual-case-of-chronic-diarrhoea-in-a-child
#17
R Goyal, U Debi, P Dey, K K Prasad, B R Thapa
Most cases of Zollinger-Ellison syndrome (ZES) are described in adults. It is a rare disorder in childhood. Most cases present with abdominal pain due to peptic ulceration and chronic diarrhoea not responding to general measures. The symptom complex is initially confused with other more common diseases, which lead to a delay in diagnosis. We present a rare case of a-12-year boy who initially presented with abdominal pain, diarrhoea, vomiting and progressive weight loss for over a two-year period before he was finally diagnosed as a case of ZES with the primary tumour in the pancreatic head and with multiple metastasis in both the liver and lymph nodes...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028303/dismal-outcome-of-therapy-related-myeloid-neoplasm-associated-with-complex-aberrant-karyotypes-and-monosomal-karyotype-a-case-report
#18
Y L Tang, W K Chia, E C S W Yap, M I Julia, C F Leong, S Salwati, C L Wong
INTRODUCTION: Individuals who are exposed to cytotoxic agents are at risk of developing therapyrelated myeloid neoplasms (t-MN). Cytogenetic findings of a neoplasm play an important role in stratifying patients into different risk groups and thus predict the response to treatment and overall survival. CASE REPORT: A 59-year-old man was diagnosed with acute promyelocytic leukaemia. Following this, he underwent all-trans retinoic acid (ATRA) based chemotherapy and achieved remission...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028302/acute-promyelocytic-leukaemia-with-a-novel-translocation-t-16-17-q12-p13-a-case-report
#19
H Bhat, S Geelani, M Rashid, T Bhat, M Qadri, N Bashir N, F Manzoor, S Bhat, F Rather, J Rasool
Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17). To the best of our knowledge this is the first case report of APML responsive to ATRA with such a translocation.
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28028301/biochemical-and-molecular-characteristics-of-malaysian-patients-with-lysinuric-protein-intolerance
#20
A Habib, N A Azize, Y Yakob, Z Md Yunus, T K Wee
Lysinuric protein intolerance (LPI) is an inborn error of dibasic amino acid transport due to a defect in the dibasic amino acid transporter in the renal and intestine and has a heterogenous presentation. Three Malaysian patients with LPI were studied and their biochemical and molecular findings compared. There were differences and similarities in the biochemical and molecular findings. Molecular analysis of SLC7A7 gene revealed a novel mutation c.235G>A; p.(Gly79Arg) in exon three in Patient 1 and a mutation c...
December 2016: Malaysian Journal of Pathology
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