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Veterinary Research Communications

Mariko Okamoto, Ai Asamura, Ko Tanaka, Takefumi Soeda, Kyo Watanabe, Hiroyuki Mizuguchi, Teruo Ikeda
Adenovirus (Ad) vectors are widely used in cancer gene therapies. However, compared to human patients, relatively limited information is available on gene transduction efficiency or cell-specific cytotoxicity in canine tumor cells transduced with Ad vectors. Since epidermal growth factor receptor (EGFR) is highly expressed on canine breast tumor cells, we sought to develop an Ad vector based on the RGD fiber-mutant adenovirus vector (AdRGD) that expresses canine caspase 3 under the control of EGFR promoter...
October 16, 2016: Veterinary Research Communications
P P Picavet, M Balligand
There is a resurgence of interest in the study of deer antlers. Recent research advocates their potential for use in bone xenografts. Using this working hypothesis, we can formulate many questions: do antlers really present unique or interesting mechanical properties, and if so, which factors affect these properties? Many other issues, including tissue compatibility, could be discussed; however, this article will focus on the biomechanical features of antlers. This paper reviews some answers found within current published material, and could help determine the optimal selection of some antlers for further experimental studies and clinical trials...
September 12, 2016: Veterinary Research Communications
Motunrayo Ganiyat Akande, Muftau Shittu, Chidiebere Uchendu, Lukuman Surakat Yaqub
Chlorpyrifos is a widely used organophosphate insecticide for domestic, agricultural and industrial purposes. Lead is a toxic heavy metal and it is used for domestic and industrial purposes. Taurine is a semi essential amino acid with bioprotective properties. The aim of this study was to investigate the effects of taurine on thyroid function in Wistar rats co-administered with chlorpyrifos and lead. The rats were divided into 5 groups of 10 rats each. The first two groups were administered with distilled water and soya oil (1 ml/kg) respectively...
August 25, 2016: Veterinary Research Communications
S Rajkhowa, D K Sarma, S R Pegu
Staphylococcus aureus is one of the most important pathogens of both humans and animal. Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen that causes serious infections both in hospitals and communities due to its multidrug resistance tendency. This study was undertaken to characterize the MRSA isolates from pigs and to determine the antimicrobial resistance of these isolates. Forty nine MRSA strains (one strain per positive pig) isolated from pigs of Northeast India were characterized by SCCmec typing and antimicrobial resistance...
July 23, 2016: Veterinary Research Communications
Andrea Pecora, María Sol Pérez Aguirreburualde, Agustín Ostachuk, Alejandra Aguirreburualde, Maria Rosa Leunda, Anselmo Odeon, Sebastián Chiavenna, Diego Bochoeyer, Marcelo Spitteler, Jorge L Filippi, Maria J Dus Santos, Susana M Levy, Andrés Wigdorovitz
No abstract text is available yet for this article.
July 7, 2016: Veterinary Research Communications
Galina P Simeonova, Svetozar Z Krastev, Radostin S Simeonov
BACKGROUND: The pathogenic mechanism of equine recurrent uveitis (ERU) is still poorly defined and many variations between experimental animal models and spontaneous disease exist. OBJECTIVES: The aim of our study was to investigate if Th17 cell-mediated response plays role in the pathogenesis of the used experimental model in horses and to reveal its pathological findings. METHODS: Experimental uveitis was induced in 6 healthy horses. The concentrations of retinal autoantigen CRALBP and IL-17 were measured using ELISA in aqueous humor and vitreous body of the 12 inflamed eyes as well as in 12 control non-inflamed eyes taken from 6 horses in slaughter house...
June 25, 2016: Veterinary Research Communications
Alessandra P S Salimena, Carla C Lange, Cecilia Camussone, Marcelo Signorini, Luis F Calvinho, Maria A V P Brito, Cristiano A V Borges, Alessandro S Guimarães, João B Ribeiro, Letícia C Mendonça, Roberta H Piccoli
Staphylococcus aureus is a pathogen that frequently causes mastitis in bovine herds worldwide. This pathogen produces several virulence factors, including cell-associated adhesins, toxic and cytolytic exoproteins, and capsular polysaccharides. The aim of the present study was to test for the presence of genes involved in capsular polysaccharide production and biofilm formation in S. aureus isolated from bovine mastitis samples collected from 119 dairy herds located in three different Brazilian regions, as well as to assay the production of capsular polysaccharides and biofilm, in vitro...
June 2, 2016: Veterinary Research Communications
Enrico Giacomini, Nicola Ferrari, Alessandra Pitozzi, Michela Remistani, Daniele Giardiello, Dominiek Maes, Giovanni Loris Alborali
In this study, we investigated the dynamics of Mycoplasma hyopneumoniae infections in 66 pig farms, with different production systems (one-, two-, and three-site systems), and considered different risk factors. Serological assay was used to detect serum antibodies against M. hyopneumoniae and real time polymerase chain reaction (RT-PCR) was performed to detect M. hyopneumoniae DNA in tracheobronchial swabs. Results demonstrated that M. hyopneumoniae infection status was predominantly influenced by the age of the animals and the type of production system...
June 2016: Veterinary Research Communications
Hao Wang, Zihua Li, Fu Gao, Jiaqing Zhao, Mingxing Zhu, Xin He, Nan Niu, Wei Zhao
OBJECTIVE: This study aims to investigate the immunoprotection of recombinant Eg.P29 (rEg.P29) vaccine and analyze the underlying mechanism in sheep. METHODS: Three groups of male sheep were immunized subcutaneously with rEg.P29 and PBS, Freund's complete adjuvant as controls, respectively. After prime-boost vaccination, the sheep were challenged with encapsulated Echinococcus granulosus eggs. The percentage of protection in sheep was determined 36 weeks after the infection...
June 2016: Veterinary Research Communications
Negar Keyshams, Morteza Zendehdel, Vahab Babapour, Ali Baghbanzadeh
The involvement of the endocannabinoid system in the brain functions is likely the conclusion of its capability to interact with specific neurotransmitters in several brain regions. The present study was designed to examine the role of the glutamatergic system on cannabinoid-induced hyperphagia in chicken. In this survey 10 experiments designed to investigate interaction of cannabinoidergic and glutamatergic systems on feeding behavior in neonatal chickens. In experiment 1, chicken were intracerebroventricular (ICV) injected with saline, 2-AG (2-Arachidonoylglycerol, 5...
June 2016: Veterinary Research Communications
M Karikalan, K Rajukumar, N Mishra, M Kumar, S Kalaiyarasu, K Rajesh, V Gavade, S P Behera, S C Dubey
In this study, cellular localization and the distribution pattern of BVDV genome in lymphoid tissues during the course of experimental acute BVDV-1 infection of sheep was investigated. Tonsils, mesenteric lymph nodes (MLN) and spleen were collected on 3, 6, 9, 12 and 15 days post infection (dpi) from twenty 4-month-old lambs, experimentally inoculated intra-nasally with 5 × 10(5) TCID50 of a non-cytopathic (ncp) BVDV-1 isolate, Ind-17555. Tissues collected from ten mock-infected lambs served as controls...
June 2016: Veterinary Research Communications
Irina Gramer, Martin Kessler, Joachim Geyer
Tyrosine kinase inhibitors (TKIs) that specifically target cKIT represent a therapeutic approach for non-resectable canine mast cell tumours (MCTs) grade II/III. The therapeutic benefit of TKIs has been investigated in other tumours based on clinical response rates and identification of gain-of-function mutations. In the present study, cKIT expression in 14 dogs with osteosarcoma, melanoma, haemangiosarcoma, lymphoma, and fibrosarcoma was analysed. Tissue samples were used for cKIT sequencing to (I) detect the cKIT transcript and to (II) identify gain-of-function mutations...
June 2016: Veterinary Research Communications
Chiara Gomiero, Giulia Bertolutti, Tiziana Martinello, Nathalie Van Bruaene, Sarah Y Broeckx, Marco Patruno, Jan H Spaas
Tendons regenerate poorly due to a dense extracellular matrix and low cellularity. Cellular therapies aim to improve tendon repair using mesenchymal stem cells and tenocytes; however, a current limitation is the low proliferative potential of tenocytes in cases of severe trauma. The purpose of this study was to develop a method useful in veterinary medicine to improve the differentiation of Peripheral Blood equine mesenchymal stem cells (PB-MSCs) into tenocytes. PB-MSCs were used to study the effects of the addition of some growth factors (GFs) as TGFβ3 (transforming growth factor), EGF2 (Epidermal growth factor), bFGF2 (Fibroblast growth factor) and IGF-1 (insulin-like growth factor) in presence or without Low Level Laser Technology (LLLT) on the mRNA expression levels of genes important in the tenogenic induction as Early Growth Response Protein-1 (EGR1), Tenascin (TNC) and Decorin (DCN)...
March 2016: Veterinary Research Communications
Alessandro Di Cerbo, Sara Centenaro, Francesca Beribè, Fulvio Laus, Matteo Cerquetella, Andrea Spaterna, Gianandrea Guidetti, Sergio Canello, Giuseppe Terrazzano
The aim of this evaluation study was to assess the possible role of a specific nutraceutical diet in relieving main clinical symptoms of chronic bilateral otitis externa (occlusion of ear canal, erythema, discharge quantity, and odor) in 30 adult dogs. Thirty dogs of different breeds (mean age ± SEM; 6.03 ± 0.15 years and mean weight ± SEM; 32.01 ± 1.17 Kg; 53.3% males, 46.6% females) with evident chronic clinical otitis symptoms were equally divided and randomly assigned to receive either the nutraceutical diet (ND group) or a standard diet (SD group) over a period of 90 days...
March 2016: Veterinary Research Communications
Chuang Xu, Qiushi Xu, Yuanyuan Chen, Wei Yang, Cheng Xia, Hongjiang Yu, Kuilin Zhu, Taiyu Shen, Ziyang Zhang
The objective of this study was to investigate the measurement of serum fibroblast growth factor-21 (FGF-21), a protein mainly synthesized by the liver, as a sensitive biomarker for diagnosis of ketosis in dairy cows. Ninety Holstein-Friesian dairy cows (60 healthy and 30 ketosis cases) were selected and divided into a Ketosis group (K), and a Control group (C). We measured serum FGF-21 and other biochemical parameters by commercial ELISA kits. In a combined population of all 90 cows, we found that serum FGF-21 level was lower (P < 0...
March 2016: Veterinary Research Communications
Amália Turner Giannico, Elaine Mayumi Ueno Gil, Daniela Aparecida Ayres Garcia, Marlos Gonçalves Sousa, Tilde Rodrigues Froes
The aim of this study was to develop regression models for correlation of canine fetal heart development with body size to characterize normal development or suggest cardiac anomalies. Twenty clinically healthy pregnant bitches, either brachycephalic and non-brachycephalic, were examined ultrasonographically. Transabdominal fetal echocardiography was conducted every 4 days from the beginning of cardiac chambers differentiation until parturition. Ten cardiac parameters were measured: length, width and diameter of the heart; heart area; left and right ventricular dimensions; left and right atrial dimensions; and aortic and pulmonary artery diameter...
March 2016: Veterinary Research Communications
Mansour Mahzouni, Morteza Zendehdel, Vahab Babapour, Saeed Charkhkar
Recently, methylamine has been found as an endogenous amine, which is controlling food intake in mammals. However, there is no evidence about the effect of methylamine on feeding behavior in poultry. So, the present study was designed to evaluate the effect of intracerebroventricular (ICV) injection of methylamine and involvement of central methylamine/dopaminergic systems on feeding behavior in neonatal meat type chicks. In experiment 1, chicks were ICV injected with different doses of methylamine (0.48, 0...
March 2016: Veterinary Research Communications
Jienny Lee, Jeong Su Byeon, Keum Sil Lee, Na-Yeon Gu, Gyeong Been Lee, Hee-Ryang Kim, In-Soo Cho, Sang-Ho Cha
Mesenchymal stem cells (MSCs) have the ability to differentiate into multi-lineage cells, which confers great promise for use in regenerative medicine. In this study, canine adipose MSCs (cAD-MSCs) were isolated from canine adipose tissue. These cells clearly represented stemness (Oct4, Sox2, and Nanog) and differentiation potential into the mesoderm (adipocytes, chondrocytes, and osteoblasts) at early passages. The aim of this study was to evaluate the effects of hypoxia on the differentiation potential into mesoderm, and the expression of anti-apoptotic genes associated with cell survival for the optimal culturing of MSCs...
March 2016: Veterinary Research Communications
Alfredo Sahagun-Ruiz, Leticia V Velazquez, Shoba Bhaskaran, Chris M Jay, E Morales-Salinas, Keerti Rathore, Gale G Wagner, Suryakant D Waghela
Neonatal calf colibacillosis caused by enterotoxigenic Escherichia coli (ETEC) is an economically significant problem in most parts of the world. The most common ETEC found in calves express the F5 (K99) fimbriae, which are necessary for the attachment of the bacteria to the ganglioside receptors on enterocytes. It is known that prevention of ETEC F5(+) adhesion to its ganglioside receptors with specific antibodies protects calves from colibacillosis. Previously we have described the development and characterization of a mouse recombinant antibody fragment (moRAb) that prevents F5 fimbrial protein induced agglutination of horse red blood cells (HRBC), which exhibit the same gangloside receptor for F5 fimbriae...
December 2015: Veterinary Research Communications
Morteza Abkar, Abbas Sahebghadam Lotfi, Jafar Amani, Khadijeh Eskandari, Mehdi Fasihi Ramandi, Jafar Salimian, Gholamreza Nikbakht Brujeni, Saeed Alamian, Mehdi Kamali, Hamid Koushki
Brucellosis is the most common zoonotic bacterial disease. Prevention of human brucellosis is achieved through pasteurization of dairy products, appropriate sanitation and vaccination of domestic animals against the Brucella species. B. abortus unlipidated 19 kDa outer membrane protein (U-Omp19) is a promising candidate for a subunit vaccine against brucellosis. This study investigates immunogenicity of Omp19 alone and with Freund's adjuvant (Omp19-IFA) and N-trimethyl chitosan (TMC/Omp19) nanoparticles, as well as the effect of Omp19 administration route on immunological responses and protection...
December 2015: Veterinary Research Communications
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