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European Journal of Gynaecological Oncology

S J Liu, W Lv, M Shi
Sclerosing stromal tumor (SST) is a rare ovarian neoplasia deriving from the sex cord stromal tumor, which occurs usually in the sec- ond and third decades of life. However, the authors report a 46-year old multiparous woman who presented with a cystic-solid left pelvic mass, a large amount of ascites, and elevated serum CA-125, all suggesting a malignant tumor. Surgery was performed and final histopathological diagnosis of the specimen was diagnosed with SST. The authors herein report an extremely rare case of SST with a cystic-solid pelvic mass and a large amount of ascites, which is useful to demonstrate the possibility of SST in multiparous woman...
2017: European Journal of Gynaecological Oncology
T Assi, E El Rassy, G Abi-Tayeh, C Sader-Ghorra, G Abadjian, R Eid, T Moussa, F Farhat, J Kattan
Rhabdomyosarcoma (RMS) occurs rarely in adults and constitutes 2-6% of all uterine neoplasms. The authors report the case of a 26-year-old woman diagnosed with botryoid RMS that presented discordant progression results on follow up imaging and cytodifferentiation on pathologic control. This case showed that radiological evaluation could be misleading as the tumor demonstrated chemotherapy-induced differentiation without volume reduction. This case illustrates the limitations of using the imaging anatomical dimensions of sarcomas for treatment planning and highlights the potential role of functional imaging to assess the response to treatment...
2017: European Journal of Gynaecological Oncology
K Y Yun, Y H Kim, D S Suh, N K Lee, K U Choi, K H Kim
Mixed endometrial stromal and smooth muscle tumor of the uterus is a rare occurrence, and it is truly challenging to diagnose or dif- ferentiate mesenchymal tumors of the uterine corpus, due to their many overlapping features. In most cases, the gross pathology of mixed endometrial stromal and smooth muscle tumor differs from that of pure endometrial stromal and pure smooth muscle tumors. A 59-year-old postmenopausal woman presented with vaginal spotting, low abdominal pain, and an uterine mass. Subsequent pelvic magnetic resonance imaging revealed a 4...
2017: European Journal of Gynaecological Oncology
A Koch, S Frigo, L Lecointre, M Hummel, C Y Akladios, J P Bergerat, G Noël, A Wattiez
Primitive Neuroectodermal tumor belongs to the family of Ewing's tumor and is characterized by at (11;22) (q24;ql2) or at (21;22) (q22;ql2) translocation. Retroperitoneal primitive neuroectodermal tumor (PNET) are rare, usually affect young adults, and are often diagnosed late. There is no specific characteristics for imaging. The diagnosis is made on histological examination of the surgical spec- imen or biopsies. Radiotherapy and chemotherapy complete the treatment. The authors report the case of a 26-year-old patient who only had pelvic discomfort...
2017: European Journal of Gynaecological Oncology
I Pimentel, A González Martin, R Bratos, R Marquez, G Toledo, L Chiva
The authors report the case of a 21-year-old woman that presented a Pseudo Meigs' syndrome, secondary to a pure endodermal sinus tumour (yolk sac tumour). Fine needle aspiration biopsy was compatible with high-grade carcinoma and the alpha fetoprotein (αFP) was at 13,185 U/ml. Cytoreductive surgery was performed, followed by bleomycin, etoposide, and cisplatin (BEP) chemotherapy.
2017: European Journal of Gynaecological Oncology
P Almeida Galvão Ferreira, C Gomes Luna, M de França Silva, L C Soares, M A Pinho de Oliveira
Plasmablastic lymphoma is highly malignant and invasive. It is most commonly found in gastrointestinal tract and is strongly asso- ciated with human immunodeficiency virus (HIV). The authors report a case of a 37-year-old HIV-positive African American woman with a vulvar mass diagnosed as plasmablastic lymphoma. Involvement of the upper gastrointestinal tract had been detected by endoscopic biopsy, suggesting that any patient diagnosed with plasmablastic lymphoma in unusual locations should be investigated for primary lesions in the gastrointestinal tract...
2017: European Journal of Gynaecological Oncology
A Zwierzchowska, G Panek, M Gajewska, E Barcz
BACKGROUND: Approximately 2-5% of women affected by endometriosis are postmenopausal. The disease may simulate various malignancies. A case of endometriosis in a postmenopausal woman, spreading similarly to ovarian cancer, is reported. A broad review of existing literature on postmenopausal endometriosis, endometriosis involving the urinary tract, and the links between endometriosis and cancer are also presented. CASE DESCRIPTION: A 51-year-old woman was diagnosed with a pelvic mass...
2017: European Journal of Gynaecological Oncology
S R He, W H Deng, L Yang, K Yang, D Cui, D G Liu
Primary adenocarcinoma of the vulva is uncommon, and cloacogenic adenocarcinoma of the vulva is extremely rare. Here the authors report a vulvar neoplasm, arising in continuity with the epidermis, characterized by villoglandular architecture, and mucinous-type ep- ithelium with intestinal differentiation (goblet cells). Histochemistry, immunohistochemistry, and gene mutation analysis revealed a colon-like pattern, except for CK7 expression. Extensive workup failed to reveal other primary cancers. In order to provide a much bet- ter experience for diagnosis, the authors compared the previously published cases with the present case regarding clinical presentation and histopathologic aspect...
2017: European Journal of Gynaecological Oncology
V G Vellone, P Sala, L Abete, F Sarocchi, L Parodi, M Valenzano Menada, E Fulcheri
Purpose ofInvestigation: Solid ovarian tumors represent a clinical challenge, in particular in case of young patients who require a fertility sparing treatment. The authors report a case of hypercellular mitotically active ovarian fibrothecoma in a very young woman, successfully treated with a fertility sparing surgery. MATERIALS AND METHODS: A 21-year-old nulliparous woman presented at the present hospital with a 14-cm right ovarian mass, consisting of solid and pseudo-cystic components...
2017: European Journal of Gynaecological Oncology
B Mize, G Salame, R Maglantay, N N Chen, Y C Lee
Primitive neuroectodermal tumors (PNET) belong to a group of highly malignant tumors comprised of small round cells of neu- roectodermal origin. These tumors can be either of peripheral-type (Ewing family tumors/PNET) or central-type. A number of case re- ports have described PNET involving the gynecologic organs and the prognosis is generally poor. The authors describe the case of a 53-year-old woman with a rapidly progressing central-type PNET of the ovary.
2017: European Journal of Gynaecological Oncology
W Szanecki, A Golonka, J Pajak, K Karcz, A Wróblewska-Czech, A Witek, A Marszałek, R Madry, J Markowska
The authors present two cases of benign tumors one located on the outer surface of the vulva, and the second extending beyond the vagina. The first, originating from the right pudendal lip, a lipoma measuring 23 cm in greatest diameter, weighing 6.6 kg, and the second a pedunculated, uterine smooth muscle myoma with a pedicle of 6.5 cm, maximum diameter 18 cm, weight 700 grams, which caused significant metroptosis. Operative procedures in each case were free of complications.
2017: European Journal of Gynaecological Oncology
G Batmaz, E Kιlιç, P Özcan, E A Sarιoğlu, N Karaca, B Dane
PURPOSE OF INVESTIGATION: The authors aimed to evaluate serum total oxidant status (TOS), total antioxidant status (TAS), and oxida- tive stress index (OSI) in women with abnormal cervical cytology, to determine the association between serum oxidant and antioxidant status of these women, and the progression of abnormal cervical cytology. MATERIALS AND METHODS: A total of 75 women enrolled in the study: 20 women with a determination of atypical squamous cells of undetermined significance (ASCUS), 20 women with low squamous intraepithelial lesions (LSIL), 15 women with high squamous intraepithelial lesions (HSIL) and 20 healthy controls...
2017: European Journal of Gynaecological Oncology
C D Chen, L N Dai, M Wang, X H Lai, J Wang
Pathological hypoxia exists in solid tumors and it creates a microenvironment for tumor cells which has a critical and complicated implication for cancer. Hypoxia can also activate autophagy which plays a dual role in cancer. In this study the authors analyzed the effect of hypoxia, the autophagy inhibitor 3-methyladenine (3-MA), cis-diamminedichloroplatinum (CDDP, cisplatin), and any combination of them on PA-l cells (a human ovarian cancer cell line) with a series of assays, focusing on autophagy induction, cell growth inhibition, and cell death by CDDP...
2017: European Journal of Gynaecological Oncology
Sh F Kong, T Lv, X Sun, H Yuan, J Y Zhong, X R Li, S Zh Dai
The purpose of this study was to evaluate the effects of stathmin-l on chkl protein expression in cervical cancer cells and the influ- ences on the cells' invasion and tumorigenicity. Suppressed stathmin-l expression in Hela cells and C33A cells by lentiviral vector were utilized. Real time PCR and Western blot were used to examine the expression of chkl. Cell proliferation and invasion were stud- ied using MTT assays and transwell migration assays.The differences of tumorigenicity in vivo were explored using xenograft experi- ments...
2017: European Journal of Gynaecological Oncology
N F Liu, Y Q Chen, J L Hu, G P Chen, T Zhu, J Q Zhu, Y Yang, H Y Sun, H Yu
OBJECTIVE: To explore the regimens and prognoses of second-line therapies for recurrent platinum-resistant ovarian epithelial cancer (OEC). MATERIALS AND METHODS: The clinical profiles and second-line regimens were retrospectively analyzed for 65 recurrent platinum-resistant OEC patients treated at Zhejiang Provincial Tumor Hospital during January 2003 to January 2013. In conjunction with literature reviews, the second-line therapies for platinum-resistant recurrent OEC were discussed...
2017: European Journal of Gynaecological Oncology
M E Căpîlna, B Szabo, S C Rusu, J Becsi, B Moldovan, R M Neagoe, G Muhlfay
PURPOSE OF INVESTIGATION: The obturator veins and their network contribute to major bleeding complications during gynaecologic surgery. MATERIALS AND METHODS: The anatomical variations of the obturator veins were studied on 106 patients in which a thorough bilateral pelvic lymphadenectomy was performed. RESULTS: Symmetrical drainage on right and left sides was found in 75 cases: only in internal iliac vein in 32 cases, both in external iliac vein and internal in 41 cases, and only in external in two cases (so called "pubic vein")...
2017: European Journal of Gynaecological Oncology
Tao Zhang, Xin Yi, Jian Lu, Aiyan Fu
Ovarian tumors present a special diagnostic challenge when imaging findings cannot be categorized into benign or malignant pathology. Magnetic resonance imaging (MRI) is currently used to evaluate ovarian tumors. The aim of this study was to evaluate the diagnostic performance of MRI in patients with benign or malignant ovarian tumors and enhance its diagnostic accuracy. The MRI findings of 48 cases of ovarian tumors, which were confirmed by surgery or pathology from September 2009 to July 2011, were analyzed ret- rospectively...
2017: European Journal of Gynaecological Oncology
N H Abdel-Hay, A A Mansour, M A El Sherbini, F I Abdel Motaleb, A H El-Shalakany
PURPOSE: To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. MATERIALS AND METHODS: Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA 125 and risk of malignancy index (RMI). RESULTS: FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate: 15/25 vs...
2017: European Journal of Gynaecological Oncology
X H Yin, Z Q Wang, Q H Guo, H Wu, M Shi
Lens epithelium-derived growth factor (LEDFG) can prevent cells apoptosis by activating stress proteins and anti-apoptotic protein, which are involved in the development of a variety of malignancies as some studies have shown. However, little is known about the role of LEDGF in cervical cancer. In this study, the authors collected 95 cases of the cervical cancer tissue samples and its matching tissue adjacent to carcinoma diagnosed by the Department of Pathology. mRNA expression of LEDFG in randomly selected 20 cervical can- cer tissues and 20 adjacent normal tissues was detected by quantitative real-time PCR (qRT-PCR)...
2017: European Journal of Gynaecological Oncology
H G Sahin, A Kolusari, H Guducuoglu
PURPOSE OF INVESTIGATION: The aim of the present study was to gather data on the high risk human papillomavirus (HPV) frequency and the distribution of HIPV types in Eastern Turkey in relation to cervical cytology and to assess the knowledge about cervical cancer, HPV, and vaccination. MATERIALS AND METHODS: The study population included 1,000 women aged between 20-65 years who attended the outpatients clinics of Department of Obstetrics and Gynecology of the Medical School of Yuzuncu Yil University Hospital...
2017: European Journal of Gynaecological Oncology
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