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European Journal of Gynaecological Oncology

L Yang, X Zhang, X Lv, H Yu
Radiotherapy and surgery are important radical treatment options for cervical cancer, but the presence of a pelvic kidney complicates the situation. Fine radiation technique can help avoiding side effects. Radiation to the modified pelvis using intensity modulated radiotherapy (IMRT) followed by brachytherapy, while avoiding the renal allograft is technically feasible which ensures adequate target volume and reduces side effects. Here, the authors report a 45-year-old patient with invasive cervical cancer with a pelvic kidney who was treated by pelvic IMRT in combination with high-dose rate brachytherapy...
2017: European Journal of Gynaecological Oncology
V Plesinac-Karapandzic, S Stojanovic Rundic, R Jankovic, M Nadrljanski, Z Milovanovic, A Tomasevic, N Perisie Jeremic
BACKGROUND: Adenocarcinoma, accounts for up to 14% of all vaginal cancer. In young patients, common histological feature is clear cell adenocarcinoma (CCA) while mesonephric adenocarcinoma (MA) is very rare. The authors report two patients in their early twenties with unilateral renal agenesis and vaginal adenocarcinoma not exposed to diethylstilbestrol (DES). CASES: Two patients with vaginal adenocarcinoma were treated, with external beam radiotherapy of pelvis combined with brachytherapy to a radical dose...
2017: European Journal of Gynaecological Oncology
S Nakamura, H Tsujioka, T Fukami, M Goto, R Matsuoka, F Eguchi
The authors here report a 54-year-old (gravida 0, para 0), who claimed to have had her menarche at age 13 and menopause at 52 years. Two months prior to presentation, the subject first noticed a hard but elastic fist-sized mass in the left inguinal region that gradually grew, causing pressure-related pain. Although the external genitalia appeared female, the vagina was short and blind-ending, and no uterus or ovaries were identified on transvaginal ultrasound. Chromosome banding results (G-band method) showed 46XY...
2017: European Journal of Gynaecological Oncology
T Matsuoka, H Tsujioka, S Matsuoka, S Sorano, A Toyama, H Mori, H Yamamoto, S Nakamura, T Fukami, M Goto, R Matsuoka, F Eguchi
Retroperitoneal leiomyosarcoma is a relatively rare and aggressive tumor. Because of its rarity, it is difficult to arrive at a definite diagnosis preoperatively and to design an effective strategy. Here the authors report a case of peritoneal leiomyosarcoma in which diagnosis was difficult because the clinical course resembled that of ovarian cancer. A 77-year-old woman diagnosed with ovarian cancer underwent laparotomy. The excised tumor contained a necrotic polypoid mass that histologically displayed the features of leiomyosarcoma...
2017: European Journal of Gynaecological Oncology
K M Gaballa, I H Metwally, B Refky, M AbdEIKhalek, S Saleh, A M Abdelaziz, M Arafa
Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal (GI ) tract tumors. Those tumors rarely arise extra intestinally; within omentum, mesentery, and rarely uterus. The authors report a case of myxoid variant of GIST arising in the ovary with no evidence of a primary tumor in the GI tract. Surgeons as well as gynecologists should bear this possibility in mind when managing pelvic masses.
2017: European Journal of Gynaecological Oncology
J H Jeon, K Jeong, H S Moon
Thickened uterine endometrium with abnormal uterine bleeding highly suggests endometrial hyperplasia or endometrial carcinoma. A case of 35-year-old nulliparous woman came to our department with endometrial mass manifesting as endometrial cancer. Transrectal ultrasonography and magnetic resonance imaging (MRI) showed an 8x6 cm multicystic, ill-defined mass compacted at the uterine endometrium, the anterior wall of the uterus, and 3x3 cm heterogenous mass at the left adnexa. The edometrial mass showed multiple septations with enhancement and low-signal intensity on T2-weighted images...
2017: European Journal of Gynaecological Oncology
F Beyazal Celiker, A Turan, M Beyazal, H Tmel Eroglu, G Bulut, N Colcimen, H Beyazal Polat
In the present case report, the authors investigated the clinicopathological characteristics of squamous cell carcinoma (SCC) arising from teratoma of the ovary and intended to report their clinical experience. Malignant transformation of ovarian teratoma is a quite rare condition with SCC observed to be the most common form of transformation. The present case was a 43-year-old female patient and her clinical presentation was abdominal pain, abdominal distension, and abdominal mass sensation. The patient underwent ultrasonography...
2017: European Journal of Gynaecological Oncology
Y Jung, J H Ahn, R Y Kim, J H Yoon, S J Lee
The loop electrosurgical excision procedure (LEEP) is commonly used to remove cervical intraepithelial neoplasia (CIN) because of its safety profile and likelihood of fewer complications. The authors report a rare case of massive retroperitoneal bleeding combined with hypovolemic shock after LEEP conization. Vessel injury was detected by angiographic computed tomography (CT) and embolization of the uterine artery was successfully performed to achieve hemostasis by an intervention radiologist. A pigtail catheter was subsequently inserted for the drainage of the large retroperitoneal hematoma...
2017: European Journal of Gynaecological Oncology
F Bellati, A Papadia, M L Gasparri, P Scanagatta, F Carriero, P Beneditti Panici, F Raspagliesi
This paper reviews the surgical approach experiences in endometrial cancer recurrence and presents for the first time data on the surgical management of endometrial cancer patients at the time of their second recurrence. Surgery could represent a pivotal role in selected cases of recurrent endometrial cancer, offering long-term complete remissions and a survival advantage.
2017: European Journal of Gynaecological Oncology
M E Capilna, B Szabo, S C Rusu, J Becsi, F C Szasz, M Morariu, B Moldovan, I M Pascanu
PURPOSE OF INVESTIGATION: Cervical cancer is one of the most frequent malignant diseases diagnosed during pregnancy. Abdominal or vaginal radical trachelectomies are fertility-preserving alternatives to radical hysterectomy for young women with early-stage cervical cancer that can be performed during ongoing pregnancy. MATERIAL AND METHODS: The authors report a pregnancy complicated by cervical cancer treated by abdominal radical trachelectomy (ART) at 16-17 gestational weeks with preservation of the concurrent pregnancy...
2017: European Journal of Gynaecological Oncology
Y Chen, Y Zhang, L Wang, X Yang
BACKGROUND: To date, cervical carcinoma complicated with Cushing's syndrome were all diagnosed as small cell carcinoma histo- logically, but not adenosquamous carcinoma. Here the authors present the diagnosis, management, and prognosis of a case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. CASE: A 28-year-old woman was admitted with the chief complaint of post-coital bleeding for one month. Gynecological examination revealed a nodular yellowish-pigmented vegetation (6x5 cm) on the cervix...
2017: European Journal of Gynaecological Oncology
T Ida, T Goto, T Motoi, I Nagai, S Matsubara, H Fujiwara, A Kohyama
A bone metastasis from uterine cervical cancer normally indicates short life expectancy. Resection of the lesion is therefore palliative. The authors consider herein whether surgical resection can promote disease control while improving quality of life. A 33-year-old woman -presenting FIGO Stage IB 1 uterine cervical squamous cell carcinoma underwent a radical hysterectomy and pelvic irradiation. Twenty-two-months later, a solitary femoral metastasis was detected. Given the pain, imminent bone fracture, the patient's relative youth, absence of other metastases, and complete control of the primary lesion, wide excision of the lesion, and reconstruction were performed...
2017: European Journal of Gynaecological Oncology
Y Cirak, O N Sever, Y Urun
Benign metastasizing leiomyoma (BML) is a rare disease that mostly occurs in women of reproductive age. Patients usually have a history of uterine leiomyoma and/or myomectomy. Although lung is the most common site of metastasis, bone involvement is rarely occurred. Here the authors report two rare cases of BML with lung and bone metastasis in postmenopausal women that were successfully treated with surgery and anti-estrogen approach.
2017: European Journal of Gynaecological Oncology
A Terjung, C Altgassen, M Friedrich
BACKGROUND: Treatment of metastatic breast cancer experienced significant improvement in the past decades by introduction of highly effective therapies, but survival still remains poor. Nonetheless, in some patients, long-term survival can be achieved by sequent endocrine and chemotherapy treatment, although toxicity and resistance eventually occur, until no further suitable and approved therapies remain. If further therapy is needed, therapist may be forced to consider treatients which are promising but not approved, such as the alkylating agent treosulfan, which is approved for the treatment of ovarian cancer only...
2017: European Journal of Gynaecological Oncology
M Khettab, E Barrascout, M Lamuraglia
The authors report a case of 84-year-old women, with dysphagia to liquids and solid foods, and with infiltration of right stemocleidomastoid muscle that compressed the upper third of the esophagus to the thoracic hull. The biopsy of sternocleidomastoid muscle permitted the diagnosis of metastatic breast cancer relapse after 22 years.
2017: European Journal of Gynaecological Oncology
K Chen, J J Ge, S X Yan, S B Ke
PURPOSE: Cervical cancer, which is treated by radiotherapy (RT) and chemoradiotherapy (CRT), has high morbidity and mortality in women. This study aimed to identify differences in gene response to CRT and RT. MATERIALS AND METHODS: GSE3578 was downloaded from Gene Expression Omnibus including specimens from 20 RT-treated patients and 19 CRT-treated patients. Differentially expressed genes (DEGs) were identified using siggenes package in R. Protein-protein interaction (PPI) network was visualized by cytoscape...
2017: European Journal of Gynaecological Oncology
D S Aydin, E Turkyilmaz, B P Goksedef, S Aydin, O Aslan, G Ateser, H Bacanakgil, B Boran
Purpose ofinvestigation: Influence of the patients' age are not well established to predict the malignancy potential of adnexal masses. This study was conducted to evaluate the impact of women's age on both histopathology and malignancy potential of adnexal masses. MATERIALS AND METHODS: This is a retrospective chart review study. Patients who were operated for suspected adnexal masses were included in the study. Malignancy potentials of tumors were divided in benign and at least borderline in univariate and multivariate analyses...
2017: European Journal of Gynaecological Oncology
X H Yin, M Shi, H Wu, L Zhou, B Xu
OBJECTIVES: To explore the relationship between HAND2 gene and protein expression and the development of endometrial carcinoma (EC). MATERIALS AND METHODS: The expression of HAND2 protein was detected by immunohistochemistry in 77 cases of EC paraffin block and their matched adjacent tissues. Western blot, real-time polymerase chain reaction (RT-PCR) were used to detect the expression of HAND2 protein and mRNA HAND2 expression in 34 cases of EC fresh tissue and paired adjacent tissues...
2017: European Journal of Gynaecological Oncology
D A Yela, M L Dos Anjos Prado, A L Leite Ribeiro Freire, C Laguna Benetti-Pinto
PURPOSE: To determine the prevalence of the gestational trophoblastic disease (GTD) and to evaluate the risk factors for persistence of the disease. MATERIALS AND METHODS: A retrospective study with 152 women diagnosed with GTD at University of Campinas from 2006 to 2013. Frequencies, average, and standard deviation were evaluated for each variable and an exact Fisher test was utilized to study persistent disease risk factors. RESULTS: The women were on average 25...
2017: European Journal of Gynaecological Oncology
N Yu, N Wang, Y F Liu, Y Y Li, T G Zhang
OBJECTIVE: This study aimed to investigate the expression of Ki-67, epithelial cadherin (E-cadherin), mesothelin, and their correlations with clinicopathological features of serous borderline ovarian tumors (SBOTs). MATERIALS AND METHODS: Immunohistochemistry was conducted to investigate the expression of a cellular proliferation-related factor (Ki-67) and metastasis-related factors (E-cadherin and mesothelin) in 41 cases of SBOTs, 30 benign ovarian tumor tissues, and 30 malignant ovarian tumor tissues...
2017: European Journal of Gynaecological Oncology
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