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European Journal of Gynaecological Oncology

C Sofoudis, A Koumousidis, E Politi, V Koutoulidis, D Hasiakos, N Salakos
Ovarian cancer is the second most common gynecologic malignancy and is one of the leading causes of death among women. The disease course and the accurate diagnosis are correlated with the early detection of the lesion. About 5% of ovarian cancers are poorly differentiated and difficult to be classified, and are referred to as undifferentiated carcinomas. They are usually large, solid with haemorrhage and necrosis, bilateral, and very difficult to be histologically classified. Generally, cases with undifferentiated components are very rare...
2016: European Journal of Gynaecological Oncology
I L Ladjevic, A Stefanovic, S Kadija, M Terzic, K Jeremic, T Janjic
INTRODUCTION: Metastatic renal cell carcinoma is often found in distant organs, including lung, bone, brain, and liver. Metastases to the vagina are extremely rare. CASE REPORT: The authors present a case of renal cell carcinoma metastasis to the anterior vaginal wall four months after nephrectomy in a 56-year-old patient. The vaginal lesions were excised. After two years the patient had no signs of recurrence or the disease progression. CONCLUSION: Vaginal metastases should be considered in differential diagnosis of female renal cell carcinoma patients presenting with vaginal bleeding of mass...
2016: European Journal of Gynaecological Oncology
R Ahdallah, B Morse, A Hakam, M M K Shahzad
Retroperitoneal squamous cell carcinoma (SCC) of unknown primary is very rare with variable survival rates. Standard optimal therapeutic management is not yet established.
2016: European Journal of Gynaecological Oncology
H Soyama, M Takano, M Miyamoto, M Kato, T Goto, K Furuya
BACKGROUND: Dedifferentiated endometrioid adenocarcinoma (DEAC) of the uterus was first described by Silva et al. in 2006. The tumor has high-grade endometrial carcinoma component which abruptly emerged from low-grade areas. DEAC showed more aggressive phenotype than FIGO grade 3 endometrioid adenocarcinoma. However, there have been a few studies evaluating effectiveness of adjuvant therapy for the patients with DEC. CASE REPORT: A 41-year-old case with Stage IVB DEAC that clinically showed resistance to several regimens of chemotherapy is reported...
2016: European Journal of Gynaecological Oncology
D H Lee
Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms of fibroblastic origin that mainly arise from the pleura. Although SFTs arising at numerous extrapleural locations have been reported, extrapleural soft tissue SFTs are extremely rare. The diagnosis of SFTs is based on histologic findings. However, given the histological variability of SFTs, immunohistochemical examination becomes important in their diagnosis. Complete surgical resection is the only and a very important prognostic factor and is recommended for the treatment of both benign and malignant SFTs with a curative intent...
2016: European Journal of Gynaecological Oncology
S Togami, T Kawamura, M Kamio, T Douchi
Malignant transformation of a mature cystic teratoma (MCT) of the ovary is rare, with squamous cell carcinoma (SCC) being the most common type. The authors report a novel case of microinvasive squamous cell carcinoma arising in a mature cystic teratoma of the ovary. A 56-year-old woman presented with a 12-cm mass, which was diagnosed as a left ovarian mature cystic teratoma preoperatively by ultrasonography. Subsequently, laparoscopic surgery for the ovarian tumor was performed. The pathologic diagnosis was microinvasive squamous cell carcinoma arising in a mature cystic teratoma of the ovary...
2016: European Journal of Gynaecological Oncology
S Xiao, Q Mu, Y Wan, M Xue
CASE: The authors report a case with spontaneous renal hemorrhage caused by invasive mole. The diagnosis was gestational trophoblastic disease (GTD), with metastasis to brain, kidneys, and lungs at Stage IV. The patient was given etoposide-methotrexate-actinomycin D plus cyclophosphamide-vincristine (EMACO) treatment regimen for 11 times including three times with consolidation chemotherapies. Laparoscopically-assisted vaginal hysterectomy (LAVH) + laparoscopic-assisted left renal excision + evacuation of the left perirenal hematoma were performed during the eighth chemotherapy...
2016: European Journal of Gynaecological Oncology
E Doğer, Y Çakiroğlu, Ö Özdamar, Y Ceylan, E Köle, I Yücesoy, E Çaliskan
OBJECTIVE: The purposes of this study were to present an endometrial cancer case with a first sign of bone metastasis, and to reveal factors affecting survival and the appropriate treatment methods for bone metastases. MATERIALS AND METHODS: A total of 101 case reports that presented with bone metastasis of endometrial cancer were reviewed in this study. RESULTS: Survival time in the patients without surgical treatment for bone metastasis was found to be 12 months (95% CI = 5...
2016: European Journal of Gynaecological Oncology
H Yoshida, D Shintani, Y Imai, K Fujiwara
Serous tubal intraepithelial carcinoma (STIC) is considered the precursor of pelvic serous carcinomas and the earliest malignant alteration in BRCA mutation-positive women. Recently, risk-reducing salpingo-oophorectomy (RRSO) is being performed in BRCA mutation-positive women and STIC is often discovered incidentally in the fallopian tubes. A 62-year-old woman underwent bilateral salpingo-oophorectomy (BSO) for ovarian cysts. Ten months later, cytological screening for the endometrium revealed adenocarcinoma...
2016: European Journal of Gynaecological Oncology
E Kurtoglu, H Celik, A Kokcu, M Kefeli, A Z Ozdemir, M Danaci
PURPOSE OF INVESTIGATION: Primary sarcomas account for of 2-3% of all female genital tract cancers and ovaries are unusual sites for sarcomas. The authors aimed to report a case of primary ovarian sarcoma. MATERIALS AND METHODS: A 46-year-old woman presented with abdominal pain and distention. Abdominal MRI revealed a 20-cm-sized complex mass in the right adnexa and ascites. Preoperative CA-125 was 289 U/ml. She underwent optimal debulking surgery and diagnosed with undifferentiated pleomorphic sarcoma with focally rhabdomyosarcomatous differentiation...
2016: European Journal of Gynaecological Oncology
Y Kemal, A Kokcu, M Kefeli, F C Tosun, G Demirag, E Kurtoglu, I Yucel
Ovarian primaries of supraclavicular metastases are extremely rare. The present study reports the case of a 64-year-old female with a left supraclavicular mass without any other symptoms. After performing a fine needle aspiration biopsy for pathological examination and positron emission imaging, she was diagnosed with FIGO Stage IV high-grade serous epithelial ovarian carcinoma. After three cycles of chemotherapy with paxlitaxel and carboplatin, complete response was achieved. There are only a few reports in literature that address patients with the initial symptom of left supraclavicular mass and final diagnosis of ovarian cancer...
2016: European Journal of Gynaecological Oncology
B Romero Guadix, N Rodríguez Ruiz, L Martínez Navarro, J Fontes Jiménez, J Mozas Moreno, M C Gonzalvo López, A Clavero Gilabert, J A Alcalá Castilla
Endometrial cancer is diagnosed increasingly in young women who wish to have children, and treatments intended to preserve fertility in these patients are becoming more common. The authors describe two women with endometrial cancer who were diagnosed and treated at our center and who needed assisted human reproductive technology, and review current knowledge based on similar cases.
2016: European Journal of Gynaecological Oncology
D H Lee
This report describes the first documented case of coexistent mesenteric and gonadal teratomas in an adult female patient. Physical examination of a 51-year-old Korean woman referred for treatment of abdominal distension and pain revealed two masses in both the right upper abdomen and in the right pelvic region. Computed tomography (CT) of the abdomen and pelvis showed the presence of well-defined, complex, fat-dense mass lesions in the upper abdomen and pelvic cavity. A large cystic mass located in the retroperitoneal space extending from the mesenteric border at the level of the transverse colon, and a goose-egg sized right ovarian mass were founded on exploratory laparotomy...
2016: European Journal of Gynaecological Oncology
P S Wang, R Wang, J Shen, X T Gao, J Zhou
OBJECTIVE: The aim of this study was to evaluate the clinical value of ultrasound-guided resection of non-palpable breast masses. MATERIALS AND METHODS: One hundred thirty-seven cases of non palpable breast mass patients who underwent surgical treatment from June 2007 to June 2012 were enrolled in this study. All patients were found with breast masses in mammography or ultrasound, and underwent preoperative routine ultrasound-guided wire positioning. RESULTS: One hundred fifty-eight lesions underwent ultrasound positioning accurate resection, of which 34 cases (21...
2016: European Journal of Gynaecological Oncology
E Bruwiere, S Van Roosbroeck, G Van Hal, J Muys, Y Jacquemyn
OBJECTIVE: To explore determinants of participation in breast cancer screening in orthodox Jewish women living in Antwerp, Belgium, and to uncover their opinions and attitudes towards screening, and thereby to detect ways to optimize participation. STUDY DESIGN: Focus group discussions were performed during the last months of 2011 and the first half of 2012 to explore motivation to participate or not in breast cancer screening. Groups consisted of five to seven women...
2016: European Journal of Gynaecological Oncology
Y Wu, D Yu, X L Bai, W Zhu, N Su
OBJECTIVE: This study aimed to explore the predictive value of the apparent diffusion coefficient (ADC) of diffusion weighted imaging (DWI) in evaluating the therapeutic effects of synchronic chemoradiotherapy of cervical squamous cell carcinoma by using the functional imaging of 1.5T MR. MATERIALS AND METHODS: Fifty patients with cervical squamous cell carcinoma receiving synchronic chemoradiotherapy in the present hospital from October 2010 to February 2014 were enrolled in this study...
2016: European Journal of Gynaecological Oncology
X Wang, J He, Y Li
PURPOSE OF INVESTIGATION: Little is known regarding ovarian yolk sac tumor (YST) in postmenopausal females. The authors aimed to investigate the clinical features and prognosis of postmenopausal patients with ovarian YST. MATERIALS AND METHODS: Five cases of ovarian YST in postmenopausal females were retrospectively reviewed. A MEDLINE search was performed to identify postmenopausal patients with ovarian YST. RESULTS: Four patients had Stage I or II disease (Stage IC, IIC, and IIB in one, two, and one patient, respectively), and one patient demonstrated an unclear stage...
2016: European Journal of Gynaecological Oncology
N Peeters, S Hulsbosch, F Ballaux, J Baekelandt
Uterine smooth muscle tumors of uncertain malignant potential, or STUMP, form a rare group of tumors that fall neither into the benign nor malignant categories. Two cases are reported, describing diagnosis, known prognostic factors, and therapy. In contrast to leiomyomas and leiomyosarcomas, many uncertainties still exist concerning prognosis and postoperative management of STUMP, because of their rarity. Diagnosis is usually not made preoperatively, but by postoperative anatomo-pathological examination. There are histological and immunohistochemical factors that could be associated with a worse prognosis, but scientific evidence is insufficient...
2016: European Journal of Gynaecological Oncology
U Metser, R McVey, S E Ferguson, J Halankar, M Q Bernardini
PURPOSE: The purpose of this pilot study was to assess feasibility, safety, and accuracy of detection of metastatic nodes intraoperatively with a hand-held gamma (PET) probe after administration of 18F-FDG in patients with high risk endometrial cancer (EC). MATERIALS AND METHODS: This is a prospective, cohort study. Twenty-two patients with clinical Stage I or II EC with high-risk histologic subtypes who were candidates for open surgical intervention were screened for the study...
2016: European Journal of Gynaecological Oncology
Longyang Liu, Juanjuan Yi, Dikai Zhang, Dongqing Zhang, San Chen, Xiao Li, Junpu Qin, Minyi Wang, Maocai Wang, Zhongqiu Lin
OBJECTIVES: To explore the relationship between aldehye dehydrogenase-1 (ALDH-1) and biological characteristics of the stable ALDH-1 knock-down Hela cell lines. MATERIALS AND METHODS: Transfected Hela cells with lentiviral vector were utilized and puromycin was used to screen and achieve the stable cell lines. The interference efficiency was calculated by performing qRT-PCR to detect the expression of ALDH-1 of three groups including the interfering group, the negative control (NC) group, and the normal Hela group...
2016: European Journal of Gynaecological Oncology
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