journal
https://read.qxmd.com/read/38537344/multi-step-strategies-for-synergistic-treatment-of-urinary-tract-infections-based-on-d-xylose-decorated-antimicrobial-peptide-carbon-dots
#1
JOURNAL ARTICLE
Chunhui Miao, Yajie Zhang, Guowen Liu, Jianming Yang, Kaiyuan Yu, Junqiang Lv, Ran Liu, Zhi Yao, Yuanjie Niu, Xiaojuan Wang, Quan Wang
Urinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC), often reoccur due to the formation of intracellular bacterial colonies (IBCs) and antibiotic resistance. Given the significance of YadC for UPEC infection in our previous study, we developed D-xylose-decorated ɛ-poly-L-lysine (εPL)-based carbon dots (D-xyl@εPLCDs) that can be traced, and employed multi-step approaches to elucidate the functional roles of D-xyl@εPLCDs in UPEC infection. Compared to undecorated particles, D-xyl@εPLCDs demonstrate YadC-dependent bacterial targeting and exhibit enhanced bactericidal activities both intracellularly and extracellularly...
March 22, 2024: Biomaterials
https://read.qxmd.com/read/38537343/an-all-in-one-therapeutic-platform-for-the-treatment-of-resistant-helicobacter-pylori-infection
#2
JOURNAL ARTICLE
Chao Sun, Jia Huang, Xiaoqian Guo, Chenli Zhang, Li Wei, Ka Ioi Wong, Ziyun Yang, Gang Zhao, Min Lu, Weiyan Yao
Helicobacter pylori (H. pylori) infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating H. pylori infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients' poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO2 @Lipo) that composed of liposomes loading clarithromycin (CLA), Bi, and ZnO2 hybrid nanoparticles was developed for eradicating multidrug-resistant (MDR) H...
March 21, 2024: Biomaterials
https://read.qxmd.com/read/38531198/mammary-tissue-derived-extracellular-matrix-hydrogels-reveal-the-role-of-irradiation-in-driving-a-pro-tumor-and-immunosuppressive-microenvironment
#3
JOURNAL ARTICLE
Tian Zhu, Steven M Alves, Arianna Adamo, Xiaona Wen, Kevin C Corn, Anastasia Shostak, Shereena Johnson, Nicholas D Shaub, Shannon E Martello, Benjamin C Hacker, Antonio D'Amore, Rizia Bardhan, Marjan Rafat
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) of irradiated breast tissue in tumor recurrence is still unknown. In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs) and developed ECM hydrogels from decellularized tissues (dECM) to assess the effects of RT-induced ECM changes on breast cancer cell behavior...
March 21, 2024: Biomaterials
https://read.qxmd.com/read/38522327/membrane-anchoring-selenophene-viologens-for-antibacterial-photodynamic-therapy-against-periodontitis-via-restoring-subgingival-flora-and-alleviating-inflammation
#4
JOURNAL ARTICLE
Rui Ding, Xu Liu, Xiaodan Zhao, Qi Sun, Yilong Cheng, Ang Li, Dandan Pei, Gang He
Antibacterial photodynamic therapy (aPDT) has emerged as a promising strategy for treating periodontitis. However, the weak binding of most photosensitizers to bacteria and the hypoxic environment of periodontal pockets severely hamper the therapeutic efficacy. Herein, two novel oxygen-independent photosensitizers are developed by introducing selenophene into viologens and modifying with hexane chains (HASeV) or quaternary ammonium chains (QASeV), which improve the adsorption to bacteria through anchoring to the negatively charged cell membrane...
March 21, 2024: Biomaterials
https://read.qxmd.com/read/38518591/a-neoteric-antibacterial-ceria-silver-nanozyme-for-abiotic-surfaces
#5
JOURNAL ARTICLE
Abinaya Sindu Pugazhendhi, Craig J Neal, Khoa Minh Ta, Marco Molinari, Udit Kumar, Fei Wei, Elayaraja Kolanthai, Andrew Ady, Christina Drake, Megan Hughes, Shibu Yooseph, Sudipta Seal, Melanie J Coathup
Community-associated and hospital-acquired infections caused by bacteria continue to yield major global challenges to human health. Bacterial contamination on abiotic surfaces is largely spread via high-touch surfaces and contemporary standard disinfection practices show limited efficacy, resulting in unsatisfactory therapeutic outcomes. New strategies that offer non-specific and broad protection are urgently needed. Herein, we report our novel ceria-silver nanozyme engineered at a molar ratio of 5:1 and with a higher trivalent (Ce3+ ) surface fraction...
March 18, 2024: Biomaterials
https://read.qxmd.com/read/38518590/plant-mucus-derived-microgels-blood-triggered-gelation-and-strong-hemostatic-adhesion
#6
JOURNAL ARTICLE
Yu Huang, Weichao Hu, Kaige Xu, Ruijue Dan, Shali Tan, Zhenzhen Shu, Xin Li, Hangzong Liu, Chaoqiang Fan, Malcolm Xing, Shiming Yang
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing and strong adhesion make them feasible as injectable bioadhesion. Exceptionally, the blood can trigger the microgels' gelation with the outcome of super extensibility, which leads to the microgels a strong hemostatic agent...
March 16, 2024: Biomaterials
https://read.qxmd.com/read/38518589/ros-responsive-drug-releasing-injectable-microgels-for-ameliorating-myocardial-infarction
#7
JOURNAL ARTICLE
Shuqin Wang, Yuejun Yao, Liang Song, Zihe Zhai, Shifen Li, Zhaolong Wang, Liyin Shen, Yang Zhu, Wenxing Liu, Changyou Gao
Despite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to in situ stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical microgels with a size of 150 μm were obtained. The MTK-TK-drug microgels efficiently converted the pro-inflammatory Th17 cells into anti-inflammatory regulatory T cells (Treg) cells in vitro, and the ROS-scavenging materials synergistically enhanced the effect by modulating the inflammation microenvironment...
March 16, 2024: Biomaterials
https://read.qxmd.com/read/38493670/ultrasound-driven-radical-chain-reaction-and-immunoregulation-of-piezoelectric-based-hybrid-coating-for-treating-implant-infection
#8
JOURNAL ARTICLE
Menglin Sun, Jiameng Wang, Xiaobo Huang, Ruiqiang Hang, Peide Han, Jiqiang Guo, Xiaohong Yao, Paul K Chu, Xiangyu Zhang
The poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x /LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methicillin-resistant Staphylococcus aureus (MRSA) infection...
March 14, 2024: Biomaterials
https://read.qxmd.com/read/38492523/-on-off-switchable-crosslinked-ptx-nanoformulation-with-improved-precise-delivery-for-nsclc-brain-metastases-and-restrained-adverse-reaction-over-nab-ptx
#9
REVIEW
Shuaijun Li, Caiting Meng, Qian Hao, Ruina Zhou, Luyao Dai, Yucheng Guo, Sitong Zhao, Xin Zhou, Chunju Lou, Ji Xu, Peng Xu, Jinfan Yang, Yifan Ding, Yanni Lv, Shengli Han, Shuai Li, Jing Li, Huafeng Kang, Zhengtao Xiao, Mingqian Tan, Xiaobin Ma, Hao Wu
Non-small cell lung cancer (NSCLC) brain metastases present a significant treatment challenge due to limited drug delivery efficiency and severe adverse reactions. In this study, we address these challenges by designing a "on/off" switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct "on/off" switchable release of the anti-cancer drug paclitaxel (PTX) in response to the acidic extratumoral microenvironment. The "off" state of BPM-PD@PTX effectively prevents premature drug release in the blood circulation, blood-brain barrier (BBB)/blood-tumor barrier (BTB), and normal brain tissue, surpassing the clinical PTX-nanoformulation (nab-PTX)...
March 14, 2024: Biomaterials
https://read.qxmd.com/read/38493671/mdsc-targeting-gold-nanoparticles-enhance-pd-1-tumor-immunotherapy-by-inhibiting-nlrp3-inflammasomes
#10
JOURNAL ARTICLE
Yangyang Zhu, Pin Chen, Bochuan Hu, Suqin Zhong, Kai Yan, Yu Wu, Shanshan Li, Yinyin Yang, Zexin Xu, Yutong Lu, Ying Ouyang, Hui Bao, Weiguang Gu, Longping Wen, Yunjiao Zhang
Myeloid-derived suppressor cells (MDSCs) play a crucial role in the immune escape mechanisms that limit the efficacy of immunotherapeutic strategies. In the tumor microenvironment, NLRP3 inflammasome-driven Interleukin-1β (IL-1β) production serves to dampen antitumor immune responses, promoting tumor growth, progression, and immunosuppression. In this study, we revealed that gold nanoparticles (Au NPs) with a size of 30 nm disrupted NLRP3 inflammasome, but not other inflammasomes, in bone marrow-derived macrophages through abrogating NLRP3-NEK7 interactions mediated by reactive oxygen species (ROS)...
March 13, 2024: Biomaterials
https://read.qxmd.com/read/38522326/progress-in-the-development-of-piezoelectric-biomaterials-for-tissue-remodeling
#11
REVIEW
Amit Nain, Srishti Chakraborty, Snigdha Roy Barman, Pratik Gavit, Sushma Indrakumar, Akhilesh Agrawal, Zong-Hong Lin, Kaushik Chatterjee
Piezoelectric biomaterials have demonstrated significant potential in the past few decades to heal damaged tissue and restore cellular functionalities. Herein, we discuss the role of bioelectricity in tissue remodeling and explore ways to mimic such tissue-like properties in synthetic biomaterials. In the past decade, biomedical engineers have adopted emerging functional biomaterials-based tissue engineering approaches using innovative bioelectronic stimulation protocols based on dynamic stimuli to direct cellular activation, proliferation, and differentiation on engineered biomaterial constructs...
March 11, 2024: Biomaterials
https://read.qxmd.com/read/38513435/degradation-controlled-tissue-extracellular-sponge-for-rapid-hemostasis-and-wound-repair-after-kidney-injury
#12
JOURNAL ARTICLE
Jae Yun Kim, Tugce Sen, Jae Yeon Lee, Dong-Woo Cho
Patients diagnosed with T1a cancer undergo partial nephrectomy to remove the tumors. In the process of removing the tumors, loss of kidney volume is inevitable, and current surgical methods focus solely on hemostasis and wound closure. Here, we developed an implantable form of decellularized extracellular matrix sponge to target both hemostasis and wound healing at the lesion site. A porous form of kidney decellularized matrix was achieved by fabricating a chemically cross-linked cryogel followed by lyophilization...
March 11, 2024: Biomaterials
https://read.qxmd.com/read/38493672/magnetic-natural-lipid-nanoparticles-for-oral-treatment-of-colorectal-cancer-through-potentiated-antitumor-immunity-and-microbiota-metabolite-regulation
#13
JOURNAL ARTICLE
Baoyi Li, Menghang Zu, Aodi Jiang, Yingui Cao, Jiaxue Wu, Mohammad-Ali Shahbazi, Xiaoxiao Shi, Rui L Reis, Subhas C Kundu, Bo Xiao
The therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic F127 (P127 ). In vitro experiments revealed that P127 functionalization and alternating magnetic fields (AMFs) promoted internalization of the obtained P127 -MLL@Gins by colorectal tumor cells and induced their apoptosis/ferroptosis through Gin/ferrous ion-induced oxidative stress and magneto-thermal effect...
March 11, 2024: Biomaterials
https://read.qxmd.com/read/38489911/perfusable-adipose-decellularized-extracellular-matrix-biological-scaffold-co-recellularized-with-adipose-derived-stem-cells-and-l6-promotes-functional-skeletal-muscle-regeneration-following-volumetric-muscle-loss
#14
JOURNAL ARTICLE
Wei Liang, Meng Han, Guan Li, Wanwen Dang, Huiting Wu, Xiaoyu Meng, Yonghuan Zhen, Weibo Lin, Rigele Ao, Xiaoqing Hu, Yang An
Muscle tissue engineering is a promising therapeutic strategy for volumetric muscle loss (VML). Among them, decellularized extracellular matrix (dECM) biological scaffolds have shown certain effects in restoring muscle function. However, researchers have inconsistent or even contradictory results on whether dECM biological scaffolds can efficiently regenerate muscle fibers and restore muscle function. This suggests that therapeutic strategies based on dECM biological scaffolds need to be further optimized and developed...
March 11, 2024: Biomaterials
https://read.qxmd.com/read/38489910/modeling-of-intravenous-caspofungin-administration-using-an-intestine-on-chip-reveals-altered-candida-albicans-microcolonies-and-pathogenicity
#15
JOURNAL ARTICLE
Tim Kaden, Raquel Alonso-Roman, Parastoo Akbarimoghaddam, Alexander S Mosig, Katja Graf, Martin Raasch, Bianca Hoffmann, Marc T Figge, Bernhard Hube, Mark S Gresnigt
Candida albicans is a commensal yeast of the human intestinal microbiota that, under predisposing conditions, can become pathogenic and cause life-threatening systemic infections (candidiasis). Fungal-host interactions during candidiasis are commonly studied using conventional 2D in vitro models, which have provided critical insights into the pathogenicity. However, microphysiological models with a higher biological complexity may be more suitable to mimic in vivo-like infection processes and antifungal drug efficacy...
March 9, 2024: Biomaterials
https://read.qxmd.com/read/38513434/local-delivery-of-stem-cell-spheroids-with-protein-polyphenol-self-assembling-armor-to-improve-myocardial-infarction-treatment-via-immunoprotection-and-immunoregulation
#16
JOURNAL ARTICLE
Chuanfeng An, Fei Shao, Canling Long, Yujie Zhang, Wen Nie, Rui Zeng, Zhenzhen Dou, Yuan Zhao, Yuanyuan Lin, Shiying Zhang, Lijun Zhang, Changle Ren, Yang Zhang, Guangqian Zhou, Huanan Wang, Jia Liu
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are limited by low cell survival and compromised functionality due to the harsh microenvironment at the disease site. Here, we presented a Mesenchymal stem cell (MSC) spheroid-based strategy for MI treatment by introducing a protein/polyphenol self-assembling armor coating on the surface of cell spheroids, which showed significantly enhanced therapeutic efficacy by actively manipulating the hostile pathological MI microenvironment and enabling versatile functionality, including protecting the donor cells from host immune clearance, remodeling the ROS microenvironment and stimulating MSC's pro-healing paracrine secretion...
March 8, 2024: Biomaterials
https://read.qxmd.com/read/38432004/an-atpase-mimicking-mxene-nanozyme-pharmacologically-breaks-the-ironclad-defense-system-for-ferroptosis-cancer-therapy
#17
JOURNAL ARTICLE
Huan Wang, Xinchen Liu, Xiangyu Yan, Yong Du, Fang Pu, Jinsong Ren, Xiaogang Qu
Anticancer nanomedicines used for ferroptosis therapy generally rely on the direct delivery of Fenton catalysts to drive lipid peroxidation in cancer cells. However, the therapeutic efficacy is limited by the ferroptosis resistance caused by the intracellular anti-ferroptotic signals. Herein, we report the intrinsic ATPase-mimicking activity of a vanadium carbide MXene nanozyme (PVCMs) to pharmacologically modulate the nuclear factor erythroid 2-related factor 2 (Nrf2) program, which is the master anti-ferroptotic mediator in the ironclad defense system in triple-negative breast cancer (TNBC) cells...
February 27, 2024: Biomaterials
https://read.qxmd.com/read/38418279/corrigendum-to-selective-binding-of-c-6oh-sulfated-hyaluronic-acid-to-the-angiogenic-isoform-of-vegf-165-biomaterials-77-2016-130-138
#18
Dong-Kwon Lim, Ryan G Wylie, Robert S Langer, Daniel S Kohane
No abstract text is available yet for this article.
February 27, 2024: Biomaterials
https://read.qxmd.com/read/38432005/ultrasound-augmented-enzyodynamic-ca-2-overload-synergetic-tumor-nanotherapy
#19
JOURNAL ARTICLE
Meiqi Chang, Lu Zhang, Tingting Zhang, Yanqiu Duan, Wei Feng, Shaoling Yang, Yu Chen, Zeyu Wang
The excessive intracellular Ca2+ can induce oxidative stress, mitochondrial damage and cell apoptosis, which has been extensively explored for tumor therapy. However, the low Ca2+ accumulation originated from Ca2+ -based nanosystems substantially weakens the therapeutic effect. Herein, a functional plant polyphenol-appended enzyodynamic nanozyme system CaFe2 O4 @BSA-curcumin (abbreviation as CFO-CUR) has been rationally designed and engineered to achieve magnified Ca2+ accumulation process, deleterious reactive oxygen species (ROS) production, as well as mitochondrial dysfunction through enzyodynamic-Ca2+ overload synergistic effect...
February 26, 2024: Biomaterials
https://read.qxmd.com/read/38430646/cuproptotic-nanoinducer-driven-proteotoxic-stress-potentiates-cancer-immunotherapy-by-activating-the-mtdna-cgas-sting-signaling
#20
JOURNAL ARTICLE
Xinying Yu, Bei Li, Jie Yan, Wenxi Li, Hao Tian, Guohao Wang, Songtao Zhou, Yunlu Dai
Proteotoxic stress, caused by the accumulation of abnormal unfolded or misfolded cellular proteins, can efficiently activate inflammatory innate immune response. Initiating the mitochondrial proteotoxic stress might go forward to enable the cytosolic release of intramitochondrial DNA (mtDNA) for the immune-related mtDNA-cGAS-STING activation, which however is easily eliminated by a cell self-protection, i.e., mitophagy. In light of this, a nanoinducer (PCM) is reported to trigger mitophagy-inhibited cuproptotic proteotoxicity...
February 26, 2024: Biomaterials
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