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Xuzhu Wang, Jundong Shao, Mustafa Abd El Raouf, Hanhan Xie, Hao Huang, Huaiyu Wang, Paul K Chu, Xue-Feng Yu, Yang Yang, AbdelBasit M AbdEl-Aal, Nefissa H M Mekkawy, Richard J Miron, Yufeng Zhang
A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2 /PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2 /PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation...
July 3, 2018: Biomaterials
Eunkyeong Jung, Joungyoun Noh, Changsun Kang, Donghyuck Yoo, Chulgyu Song, Dongwon Lee
Muscles of peripheral artery disease (PAD) patients are under oxidative stress associated with a significantly elevated level of reactive oxygen species (ROS) including hydrogen peroxide (H2 O2 ). Curcumin is a major active constituent of turmeric and is well known for its highly potent antioxidant, anti-inflammatory and angiogenic effects. We previously reported antioxidant vanillyl alcohol-incorporated copolyoxalate (PVAX) which is designed to rapidly scavenge H2 O2 and release bioactive vanillyl alcohol and CO2 in a H2 O2 -triggered manner...
July 2, 2018: Biomaterials
Akihiro Nishiguchi, Michiya Matsusaki, Mitsunobu R Kano, Hiroshi Nishihara, Daisuke Okano, Yoshiya Asano, Hiroshi Shimoda, Satoko Kishimoto, Soichi Iwai, Mitsuru Akashi
Tumour models mimicking in vivo three-dimensional (3D) microenvironments are of increasing interest in drug discovery because of the limitations inherent to current models. For example, preclinical assays that rely on monolayer or spheroid cell cultures cannot easily predict 3D cancer behaviours because they have no vasculature. Furthermore, there are major differences in cancer behaviour between human and animal experiments. Here, we show the construction of 3D blood/lymph-vascularized human stromal tissues that can be combined with cancer cells to mimic dynamic metastasis for real-time throughput screening of secreted proteinases...
July 2, 2018: Biomaterials
Zhide Guo, Mei Chen, Chenyu Peng, Shiguang Mo, Changrong Shi, Guifeng Fu, Xuejun Wen, Rongqiang Zhuang, Xinhui Su, Ting Liu, Nanfeng Zheng, Xianzhong Zhang
Radiolabeled nanomaterials, especially those with ultra-small structures, have been the research focus in recent years, and thus may open up new prospects for clinical diseases theranostics. Herein, fluorinated Pd nanosheets labeled with Gd or radionuclides are developed as multimodal platforms for tumor theranostics. These nanomaterials decorated by functional polyethylene glycol demonstrate ultrahigh 19 F MRI signal, ultrasmall size and good dispersibility. These ultrasmall materials exhibit good biocompatibility and easily to be modified for multimodal imaging (SPECT/MRI/PAI) by assembling the functional groups like building blocks...
June 30, 2018: Biomaterials
Qiong Wu, Jie Yu, Mei Li, Longfei Tan, Xiangling Ren, Changhui Fu, Zengzhen Chen, Feng Cao, Jun Ren, Laifeng Li, Ping Liang, Yu Zhang, Xianwei Meng
Usually the tumor thermal therapy is accompanied with inflammatory reactions, which in turn promote tumor growth and metastasis meanwhile. Herein, we prepared novel trifunctional PEG-IL/ZrO2 -Ag@SiO2 nanorattles, which can be used for CT imaging-guided simultaneous tumor microwave thermal therapy and resistance to bacterial infection. Under the microwave irradiation, the nanorattles present excellent microwave thermal properties. Simultaneously, the nanorattles have good antibacterial effect in vitro and in vivo, which can restrain bacterial growth effectively and reduce inflammation response during the microwave thermal therapy...
June 30, 2018: Biomaterials
Kevin T Campbell, Roberta S Stilhano, Eduardo A Silva
The objective of this study was to design an injectable biomaterial system that becomes porous in situ to deliver and control vascular progenitor cell release. Alginate hydrogels were loaded with outgrowth endothelial cells (OECs) and alginate lyase, an enzyme which cleaves alginate polymer chains. We postulated and confirmed that higher alginate lyase concentrations mediated loss of hydrogel mechanical properties. Hydrogels incorporating 5 and 50 mU/mL of alginate lyase experienced approximately 28% and 57% loss of mass as well as 81% and 91% reduction in storage modulus respectively after a week...
June 27, 2018: Biomaterials
Zhiyi Liu, Lucia Speroni, Kyle P Quinn, Carlo Alonzo, Dimitra Pouli, Yang Zhang, Emily Stuntz, Carlos Sonnenschein, Ana M Soto, Irene Georgakoudi
Hormones play an important role in normal and diseased breast tissue development. However, they can also disrupt cell-matrix interactions and their role in extracellular matrix reorganization during epithelial morphogenesis remains poorly understood, partly due to a lack of sensitive approaches for matrix characterization. Here, we assess the hormonal regulation of matrix reorganization in a three-dimensional (3D) breast tissue culture model using a novel metric, i.e., 3D directional variance, to characterize the 3D organization of collagen fibers visualized via high-resolution, second harmonic generation imaging...
June 26, 2018: Biomaterials
Chunyu Liu, Weihe Yao, Meng Tian, Junnan Wei, Qiling Song, Weihong Qiao
High-performance hemostasis becomes increasingly essential in civilian and military trauma. However, available topical hemostats still exist various drawbacks and side-effects. Herein, a silica nanoparticle coated with polydopamine (PDA/SiNP) with good degradability, antibacterial performance was developed for hemorrhage control. PDA/SiNP formed a porous network via lyophilization and rendered material with phenol hydroxyls, aminos, proper hydrophobicity, promising for further cells aggregation and inducing clotting...
June 26, 2018: Biomaterials
Sichang Lu, Madison A P McGough, Stefanie M Shiels, Katarzyna J Zienkiewicz, Alyssa R Merkel, Joseph P Vanderburgh, Jeffry S Nyman, Julie A Sterling, David J Tennent, Joseph C Wenke, Scott A Guelcher
Bone fractures at weight-bearing sites are challenging to treat due to the difficulty in maintaining articular congruency. An ideal biomaterial for fracture repair near articulating joints sets rapidly after implantation, stabilizes the fracture with minimal rigid implants, stimulates new bone formation, and remodels at a rate that maintains osseous integrity. Consequently, the design of biomaterials that mechanically stabilize fractures while remodeling to form new bone is an unmet challenge in bone tissue engineering...
June 26, 2018: Biomaterials
Liting Jiang, Wenjie Zhang, Li Wei, Qi Zhou, Guangzheng Yang, Niandong Qian, Yun Tang, Yiming Gao, Xinquan Jiang
The decreased bone mass and impaired osteogenesis capacities that occur with aging may influence the outcome of dental implants. Parathyroid hormone (PTH) (1-34) is an anabolic agent for the treatment of osteoporosis. However, little is known about its effects and mechanisms on vascularized bone regeneration and implant osseointegration in aging. In current study, we adopted both in vivo and in vitro approaches to explore the mechanisms of early actions of PTH (1-34) on the angiogenic and osteogenic microenvironment to enhance implant osseointegration in aged rats...
June 26, 2018: Biomaterials
Hang Lin, Jihee Sohn, He Shen, Mark T Langhans, Rocky S Tuan
Bone has well documented natural healing capacity that normally is sufficient to repair fractures and other common injuries. However, the properties of bone change throughout life, and aging is accompanied by increased incidence of bone diseases and compromised fracture healing capacity, which necessitate effective therapies capable of enhancing bone regeneration. The therapeutic potential of adult mesenchymal stem cells (MSCs) for bone repair has been long proposed and examined. Actions of MSCs may include direct differentiation to become bone cells, attraction and recruitment of other cells, or creation of a regenerative environment via production of trophic growth factors...
June 22, 2018: Biomaterials
Netta Vidavsky, Jennie Amr Kunitake, Aaron E Chiou, Paul A Northrup, Teresa J Porri, Lu Ling, Claudia Fischbach, Lara A Estroff
Microcalcifications serve as diagnostic markers for breast cancer, yet their formation pathway(s) and role in cancer progression are debated due in part to a lack of relevant 3D culture models that allow studying the extent of cellular regulation over mineralization. Previous studies have suggested processes ranging from dystrophic mineralization associated with cell death to bone-like mineral deposition. Here, we evaluated microcalcification formation in 3D multicellular spheroids, generated from non-malignant, pre-cancer, and invasive cell lines from the MCF10A human breast tumor progression series...
June 22, 2018: Biomaterials
Fang Chen, Gongyi Li, Eric Ruike Zhao, Jingting Li, Ghanim Hableel, Jeanne E Lemaster, Yuting Bai, George L Sen, Jesse V Jokerst
Silicon carbide has been shown to be biocompatible and is used as a coating material for implanted medical devices to prevent biofilms. Silicon carbide nanomaterials are also promising in cell tracking due to their stable and strong luminescence, but more comprehensive studies of this material on the nanoscale are needed. Here, we studied the toxicity of silicon carbide nanomaterials on human mesenchymal stem cells in terms of metabolism, viability, adhesion, proliferation, migration, oxidative stress, and differentiation ability...
June 22, 2018: Biomaterials
Shixuan Chen, Mark A Carlson, Yu Shrike Zhang, Yong Hu, Jingwei Xie
Uncontrolled hemorrhage, which typically involves the torso and/or limb junctional zones, remains a great challenge in the prehospital setting. Here, we for the first time report an injectable and superelastic nanofiber rectangle matrix ("peanut") fabricated by a combination of electrospinning, gas foaming, hydrogel coating and crosslinking techniques. The compressed nanofiber peanut is capable of re-expanding to its original shape in atmosphere, water and blood within 10 s. Such nanofiber peanuts exhibit greater capacity of water/blood absorption compared to current commercial products and high efficacy in whole blood clotting assay, in particular for thrombin-immobilized samples...
June 22, 2018: Biomaterials
Gang Jia, Yong Han, Yanli An, Yinan Ding, Chen He, Xihui Wang, Qiusha Tang
Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse and restriction of drugs by the blood-brain barrier (BBB) from entering the brain and influencing tumor growth. However, a safe BBB-traversing drug delivery system has brought new hope to glioma treatment. Exosomes have strong cargo-loading capacity and have the ability to cross the BBB. They can also be conferred with the ability for targeted delivery. Therefore, exosomes have great promise to be a targeted drug delivery vehicles...
June 21, 2018: Biomaterials
Haidong Li, Qichao Yao, Feng Xu, Ning Xu, Ran Duan, Saran Long, Jiangli Fan, Jianjun Du, Jingyun Wang, Xiaojun Peng
Development of high selectivity, accurate targeted and noninvasive fluorescent probe for monitoring specific enzyme activity associated with the tumor is urgent needed for early diagnosis of cancer and clinical fluorescence interventional resection guidance treatment. Owing to the invasion of malignant tumor cells, tumor cells are mixed with normal cells in the actual tumor location, which make it quite difficult for clinician to diagnose early diagnosis of tumor as well as resection of tumor. To overcome aforementioned obstacle, herein, an ingenious enzyme-activated one and two-photon fluorescent probe TCF-GGT was constructed and synthesized including γ-GGT enzyme specific identification site and far-red fluorophore for imaging...
June 21, 2018: Biomaterials
Bowen Wang, Guojun Chen, Go Urabe, Ruosen Xie, Yuyuan Wang, Xudong Shi, Lian-Wang Guo, Shaoqin Gong, K Craig Kent
Drug-eluting stents are the most commonly employed method to control post-angioplasty restenosis. Unfortunately, they exacerbate life-threatening stent thrombosis because of endothelium damage caused by both drug and stenting. To solve this major medical problem, an endothelium-protective and stent-free anti-restenotic method is highly desirable. Here we have generated a biomimetic intravenous delivery system using dendritic polymer-based nanoclusters, which were coated with platelet membranes for targeting to the injured arterial wall where restenosis occurs...
June 18, 2018: Biomaterials
Tongmeng Jiang, Dan Kai, Sijia Liu, Xianyuan Huang, Shujun Heng, Jinmin Zhao, Benjamin Qi Yu Chan, Xian Jun Loh, Ye Zhu, Chuanbin Mao, Li Zheng
Cartilage cannot self-repair and thus regeneration is a promising approach to its repair. Here we developed new electrospun nanofibers, made of poly (ε-caprolactone)/polytetrahydrofuran (PCL-PTHF urethane) and collagen I from calf skin (termed PC), to trigger the chondrogenic differentiation of mesenchymal stem cells (MSCs) and the cartilage regeneration in vivo. We found that the PC nanofibers had a modulus (4.3 Mpa) lower than the PCL-PTHF urethane nanofibers without collagen I from calf skin (termed P) (6...
June 18, 2018: Biomaterials
Evan M Chen, Amanda R Quijano, Young-Eun Seo, Christopher Jackson, Alexander D Josowitz, Seth Noorbakhsh, Andrea Merlettini, Ranjini K Sundaram, Maria Letizia Focarete, Zhaozhong Jiang, Ranjit S Bindra, W Mark Saltzman
Intracranial delivery of therapeutic agents is limited by penetration beyond the blood-brain barrier (BBB) and rapid metabolism of the drugs that are delivered. Convection-enhanced delivery (CED) of drug-loaded nanoparticles (NPs) provides for local administration, control of distribution, and sustained drug release. While some investigators have shown that repeated CED procedures are possible, longer periods of sustained release could eliminate the need for repeated infusions, which would enhance safety and translatability of the approach...
June 18, 2018: Biomaterials
Lorenzo Tozzi, Pierre-Alexandre Laurent, Christian A Di Buduo, Xuan Mu, Angelo Massaro, Ross Bretherton, Whitney Stoppel, David L Kaplan, Alessandra Balduini
In the bone marrow, the interaction of progenitor cells with the vasculature is fundamental for the release of blood cells into circulation. Silk fibroin, derived from Bombyx mori silkworm cocoons, is a promising protein biomaterial for bone marrow tissue engineering, because of its tunable architecture and mechanical properties, the capacity to incorporate labile compounds without loss of bioactivity and the demonstrated ability to support blood cell formation without premature activation. In this study, we fabricated a custom perfusion chamber to contain a multi-channel lyophilized silk sponge mimicking the vascular network in the bone marrow niche...
June 16, 2018: Biomaterials
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