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Biomaterials

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https://www.readbyqxmd.com/read/30216806/smart-vaccine-delivery-based-on-microneedle-arrays-decorated-with-ultra-ph-responsive-copolymers-for-cancer-immunotherapy
#1
Huu Thuy Trang Duong, Yue Yin, Thavasyappan Thambi, Thanh Loc Nguyen, V H Giang Phan, Min Sang Lee, Jung Eun Lee, Jaeyun Kim, Ji Hoon Jeong, Doo Sung Lee
Despite the tremendous potential of DNA-based cancer vaccines, their efficacious delivery to antigen presenting cells to stimulate both humoral and cellular response remains a major challenge. Although electroporation-based transfection has improved performance, an optimal strategy for safe and pain-free vaccination technique remains elusive. Herein, we report a smart DNA vaccine delivery system in which nanoengineered DNA vaccine was laden on microneedles (MNs) assembled with layer-by-layer coating of ultra-pH-responsive OSM-(PEG-PAEU) and immunostimulatory adjuvant poly(I:C), a synthetic double stranded RNA...
September 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/30218835/towards-biobanking-technologies-for-natural-and-bioengineered-multicellular-placental-constructs
#2
Olena Pogozhykh, Volodymyr Prokopyuk, Olga Prokopyuk, Larisa Kuleshova, Anatoliy Goltsev, Constança Figueiredo, Denys Pogozhykh
Clinical application of a large variety of biomaterials is limited by the imperfections in storage technology. Perspective approaches utilizing low-temperature storage are especially challenging for multicellular structures, such as tissues, organs, and bioengineered constructs. Placenta, as a temporary organ, is a widely available unique biological material, being among the most promising sources of various cells and tissues for clinical and experimental use in regenerative medicine and tissue engineering...
September 7, 2018: Biomaterials
https://www.readbyqxmd.com/read/30218836/ros-induced-no-generation-for-gas-therapy-and-sensitizing-photodynamic-therapy-of-tumor
#3
Shuang-Shuang Wan, Jin-Yue Zeng, Han Cheng, Xian-Zheng Zhang
This study reports a tumor-specific ROS-responsive nanoplatform capable of the combination of nitric oxide (NO)-based gas therapy and sensitized photodynamic therapy (PDT). The nanoplatform is constructed on porous coordination network (PCN), which contains NO donor L-Arg and is concurrently coated with cancer cell membrane (L-Arg@PCN@Mem). Under near infrared light (NIR) irradiation, L-Arg@PCN@Mem produces plenty of reactive oxygen species (ROS) directly for PDT therapy, while a part of ROS take the role of oxidative to converse L-Arg into NO for combined gas therapy...
September 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/30195803/ultra-high-fret-efficiency-nagdf-4-tb-3-rose-bengal-biocompatible-nanocomposite-for-x-ray-excited-photodynamic-therapy-application
#4
Wenli Zhang, Xiaofeng Zhang, Yingli Shen, Feng Shi, Chaojun Song, Tianshuai Liu, Peng Gao, Bin Lan, Miao Liu, Sicheng Wang, Li Fan, Hongbing Lu
The limitation of light penetration depth invalidates the application of photodynamic therapy in deep-seated tumors. X-ray excited photodynamic therapy (X-PDT), which is based on X-rays excited luminescent nanoparticles (XLNP), provides a new strategy for PDT in deep tissues. However, the high X-ray dosage used and non-specific cytotoxicity of the nanoparticle-photosensitizer nanocomposite (NPs-PS) hamper in-vivo X-PDT applications. To address these problems, a simple and efficient NPs-PS nanocomposite using β-NaGdF4 : Tb3+ nanoparticles and widely used PS called Rose Bengal (RB) was designed...
September 5, 2018: Biomaterials
https://www.readbyqxmd.com/read/30216807/preconditioning-of-bone-marrow-derived-mesenchymal-stem-cells-with-n-acetyl-l-cysteine-enhances-bone-regeneration-via-reinforced-resistance-to-oxidative-stress
#5
Jun Watanabe, Masahiro Yamada, Kunimichi Niibe, Maolin Zhang, Takeru Kondo, Minoru Ishibashi, Hiroshi Egusa
Oxidative stress on transplanted bone marrow-derived mesenchymal stem cells (BMSCs) during acute inflammation is a critical issue in cell therapies. N-acetyl-L cysteine (NAC) promotes the production of a cellular antioxidant molecule, glutathione (GSH). The aim of this study was to investigate the effects of pre-treatment with NAC on the apoptosis resistance and bone regeneration capability of BMSCs. Rat femur-derived BMSCs were treated in growth medium with or without 5 mM NAC for 6 h, followed by exposure to 100 μM H2 O2 for 24 h to induce oxidative stress...
September 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/30195801/lung-endothelial-cell-targeted-peptide-guided-bfgf-promotes-the-regeneration-after-radiation-induced-lung-injury
#6
Dongwei Guan, Junwei Mi, Xi Chen, Yonghui Wu, Yuanjiang Yao, Linjie Wang, Zhifeng Xiao, Yannan Zhao, Bing Chen, Jianwu Dai
Basic fibroblast growth factor (bFGF) can protect the lung against radiation-induced pulmonary vascular endothelial apoptosis and subsequent radiation-induced lung injury (RILI). However, guiding bFGF to pulmonary vascular endothelial cells is a key determinant for the success of bFGF therapy. To improve the lung-targeting ability of bFGF, a lung endothelial cell-targeting peptide was fused to bFGF (LET-bFGF). An in vitro biological activity assay indicated that fusion of LET did not affect the bioactivity of bFGF...
September 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/30216805/multivalent-biomaterial-platform-to-control-the-distinct-arterial-venous-differentiation-of-pluripotent-stem-cells
#7
Taylor B Dorsey, Diana Kim, Alexander Grath, Daylon James, Guohao Dai
Vascular endothelial cells (ECs) differentiated from pluripotent stem cells have enormous potential to be used in a variety of therapeutic areas such as tissue engineering of vascular grafts and re-vascularization of ischemic tissues. To date, various protocols have been developed to differentiate stem cells toward vascular ECs. However, current methods are still not sufficient to drive the distinct arterial venous differentiation. Therefore, developing refined method of arterial-venous differentiation is critically needed to address this gap...
September 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/30195802/a-novel-galactose-peg-conjugated-biodegradable-copolymer-is-an-efficient-gene-delivery-vector-for-immunotherapy-of-hepatocellular-carcinoma
#8
Ling Liu, Zhi-Min Zong, Qian Liu, Shuang-Shuang Jiang, Qian Zhang, Lan-Qi Cen, Jian Gao, Xiao-Ge Gao, Jian-Dong Huang, Yi Liu, Hong Yao
Successful immunogene therapy depends not only on the therapeutic gene but also on the gene delivery vector. In this study, we synthesized a novel copolymer consisting of low-molecular-weight polyethylenimine (PEI) cross-linked by myo-inositol (INO) and conjugated with a galactose-grafted PEG chain, named LA-PegPI. We characterized the chemical structure and molecular weight of the copolymer and particle properties of LA-PegPI/pDNA. Furthermore, we showed that LA-PegPI/pDNA polyplexes possessed excellent stability in physiological salt solution, low cytotoxicity, and high transfection efficiency in the asialoglycoprotein receptor (ASGPR)-positive liver cells in vitro...
September 1, 2018: Biomaterials
https://www.readbyqxmd.com/read/30205243/minimum-structural-requirements-for-bmp-2-binding-of-heparin-oligosaccharides
#9
Raymond A A Smith, Sadasivam Murali, Bina Rai, Xiaohua Lu, Zophia Xue Hui Lim, Jaslyn J L Lee, Victor Nurcombe, Simon M Cool
Bone morphogenetic proteins (BMPs) are essential during tissue repair and remodeling after injury. Glycosaminoglycan (GAG) sugars are known to enhance BMP activity in vitro and in vivo; here the interactions of BMP-2 with various glycosaminoglycan classes were compared and shown to be selective for heparin over other comparable saccharides. The minimal chain lengths and specific sulfate moieties required for heparin-derived oligosaccharide binding to BMP-2, and the ability of such oligosaccharides to promote BMP-2-induced osteogenic differentiation in vitro were then determined...
August 31, 2018: Biomaterials
https://www.readbyqxmd.com/read/30180985/electrical-stimulation-increases-hypertrophy-and-metabolic-flux-in-tissue-engineered-human-skeletal-muscle
#10
Alastair Khodabukus, Lauran Madden, Neel K Prabhu, Timothy R Koves, Christopher P Jackman, Deborah M Muoio, Nenad Bursac
In vitro models of contractile human skeletal muscle hold promise for use in disease modeling and drug development, but exhibit immature properties compared to native adult muscle. To address this limitation, 3D tissue-engineered human muscles (myobundles) were electrically stimulated using intermittent stimulation regimes at 1 Hz and 10 Hz. Dystrophin in myotubes exhibited mature membrane localization suggesting a relatively advanced starting developmental maturation. One-week stimulation significantly increased myobundle size, sarcomeric protein abundance, calcium transient amplitude (∼2-fold), and tetanic force (∼3-fold) resulting in the highest specific force generation (19...
August 31, 2018: Biomaterials
https://www.readbyqxmd.com/read/30195140/immunomodulatory-properties-of-chitosan-polymers
#11
REVIEW
Hannah B T Moran, Joanna L Turley, Mats Andersson, Ed C Lavelle
The introduction of vaccines is regarded as one of the most successful medical interventions to date. However, there is a clear need for the development of new vaccines for diseases which require the induction of a potent cellular immune response. Advancements in the field of vaccine research have resulted in a move away from the use of whole organisms and towards the use of subunit vaccines which consist of highly purified antigens with an improved safety profile. Adjuvants are immunostimulatory components that are included in subunit vaccine formulations to help direct and amplify adaptive immune responses...
August 30, 2018: Biomaterials
https://www.readbyqxmd.com/read/30193908/microfluidic-devices-for-disease-modeling-in-muscle-tissue
#12
Mollie M Smoak, Hannah A Pearce, Antonios G Mikos
Microfluidic devices have advanced significantly in recent years and are a promising technology for the field of tissue engineering. Highly sophisticated microfabrication techniques have paved the way for the development of complex ex vivo models capable of incorporating and measuring the real-time response of multiple cell types interacting together in a single system. Muscle-on-a-chip technology has drastically improved and serves as a drug screening platform for many muscular diseases such as muscular dystrophy, tendinosis, fibromyalgia, mitochondrial myopathy, and myasthenia gravis...
August 30, 2018: Biomaterials
https://www.readbyqxmd.com/read/30179778/tumor-hypoxia-directed-multimodal-nanotherapy-for-overcoming-drug-resistance-in-renal-cell-carcinoma-and-reprogramming-macrophages
#13
Hashem O Alsaab, Samaresh Sau, Rami M Alzhrani, Vino T Cheriyan, Lisa A Polin, Ulka Vaishampayan, Arun K Rishi, Arun K Iyer
Drug resistance is one of the significant clinical burden in renal cell carcinoma (RCC). The development of drug resistance is attributed to many factors, including impairment of apoptosis, elevation of carbonic anhydrase IX (CA IX, a marker of tumor hypoxia), and infiltration of tumorigenic immune cells. To alleviate the drug resistance, we have used Sorafenib (Sor) in combination with tumor hypoxia directed nanoparticle (NP) loaded with a new class of apoptosis inducer, CFM 4.16 (C4.16), namely CA IX-C4.16...
August 30, 2018: Biomaterials
https://www.readbyqxmd.com/read/30170258/corrigendum-to-fabrication-of-nanofibrous-microcarriers-mimicking-extracellular-matrix-for-functional-microtissue-formation-and-cartilage-regeneration-biomaterials-171-2018-118-132
#14
Yansen Wang, Xueling Yuan, Kun Yu, Haoye Meng, Yudong Zheng, Jiang Peng, Shibi Lu, Xiaotong Liu
No abstract text is available yet for this article.
August 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/30172243/a-novel-plectin-integrin-targeted-bispecific-molecular-probe-for-magnetic-resonance-near-infrared-imaging-of-pancreatic-cancer
#15
Qian Wang, Hao Yan, Yushen Jin, Zihua Wang, Wenhui Huang, Jia Qiu, Feiyu Kang, Kun Wang, Xinming Zhao, Jie Tian
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies with poor patient outcomes often resulting from delayed diagnosis. Therefore, early diagnosis can lead to a better prognosis and improved outcomes. In this study, we have developed a novel conjugate complex of plectin/integrin-targeted bispecific molecular probe, termed Gd-Cy7-PTP/RGD, to be used for magnetic resonance/near-infrared imaging (MRI/NIRF) of pancreatic cancer in vivo. This bispecific molecular probe comprises four parts: Gd(III) for MRI, cyanine 7 (Cy7) for NIRF, the peptide PTP for binding to plectin-1 specifically overexpressed on the surface of PDAC cells, and the peptide RGD for targeting integrin widely expressed on pancreatic duct epithelial cells and angiogenesis...
August 26, 2018: Biomaterials
https://www.readbyqxmd.com/read/30176403/virus-mimetic-polymer-nanoparticles-displaying-hemagglutinin-as-an-adjuvant-free-influenza-vaccine
#16
Chaeyeon Lee, Jonghwa Jeong, Taeheon Lee, Wei Zhang, Li Xu, Ji Eun Choi, Ji Hyun Park, Jae Kwang Song, Sinae Jang, Chi-Yong Eom, KyuHwan Shim, A An Seong Soo, Young-Sun Kang, Minseok Kwak, Hyeong Jin Jeon, Jeung Sang Go, Yung Doug Suh, Jun-O Jin, Hyun-Jong Paik
The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutinin1 on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features...
August 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/30174198/3d-culture-models-for-studying-branching-morphogenesis-in-the-mammary-gland-and-mammalian-lung
#17
Bryan A Nerger, Celeste M Nelson
The intricate architecture of branched tissues and organs has fascinated scientists and engineers for centuries. Yet-despite their ubiquity-the biophysical and biochemical mechanisms by which tissues and organs undergo branching morphogenesis remain unclear. With the advent of three-dimensional (3D) culture models, an increasingly powerful and diverse set of tools are available for investigating the development and remodeling of branched tissues and organs. In this review, we discuss the application of 3D culture models for studying branching morphogenesis of the mammary gland and the mammalian lung in the context of normal development and disease...
August 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/30170256/gemcitabine-loaded-dspe-peg-pheoa-liposome-as-a-photomediated-immune-modulator-for-cholangiocarcinoma-treatment
#18
Da Hye Kim, Byeong Nam Im, Hee Sook Hwang, Kun Na
To improve the therapeutic efficacy of gemcitabine (GEM) as an anticancer drug for bile duct cancer, GEM-loaded liposomes (GDPPL) prepared from a photosensitizer-conjugated lipid were investigated regarding the drug release kinetics, photodynamic therapy (PDT) efficacy, and immunomodulatory effects. The release rate of GEM from the liposomes was improved approximately 2-fold compared to non-laser irradiation groups due to lipid disruption by reactive oxygen species produced from the activated photosensitizer upon laser irradiation...
August 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/30172245/the-role-of-oligodendrocytes-and-their-progenitors-on-neural-interface-technology-a-novel-perspective-on-tissue-regeneration-and-repair
#19
REVIEW
Steven M Wellman, Franca Cambi, Takashi Dy Kozai
Oligodendrocytes and their precursors are critical glial facilitators of neurophysiology, which is responsible for cognition and behavior. Devices that are used to interface with the brain allow for a more in-depth analysis of how neurons and these glia synergistically modulate brain activity. As projected by the BRAIN Initiative, technologies that acquire a high resolution and robust sampling of neural signals can provide a greater insight in both the healthy and diseased brain and support novel discoveries previously unobtainable with the current state of the art...
August 22, 2018: Biomaterials
https://www.readbyqxmd.com/read/30153562/a-collagen-microchannel-scaffold-carrying-paclitaxel-liposomes-induces-neuronal-differentiation-of-neural-stem-cells-through-wnt-%C3%AE-catenin-signaling-for-spinal-cord-injury-repair
#20
Xiaoran Li, Caixia Fan, Zhifeng Xiao, Yannan Zhao, Haimin Zhang, Jie Sun, Yan Zhuang, Xianming Wu, Jiajia Shi, Yanyan Chen, Jianwu Dai
Neural stem cells (NSCs) show potential for spinal cord injury (SCI) repair. However, the current challenge is to direct their differentiation into neurons in the lesion site. It has been demonstrated that transplanted NSCs primarily differentiated into astrocytes rather than neurons due to the adverse microenvironment. It was reported that microtubule-stabilizing agent paclitaxel (PTX) was able to reduce scarring and enhance intrinsic axon regeneration after SCI. In this study, the effect of PTX on NSC differentiation was studied...
August 22, 2018: Biomaterials
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