journal
MENU ▼
Read by QxMD icon Read
search

Clinics in Laboratory Medicine

journal
https://www.readbyqxmd.com/read/28457357/preface
#1
EDITORIAL
Nahed Ismail, James W Snyder, A William Pasculle
No abstract text is available yet for this article.
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457356/rickettsiae-as-emerging-infectious-agents
#2
REVIEW
Rong Fang, Lucas S Blanton, David H Walker
With advances in molecular genetics, more pathogenic rickettsial species have been identified. Pathogenic rickettsiae are transmitted by vectors, such as arthropods, into the patient's skin and then spread into the microvascular endothelial cells. Clinical manifestations are characterized by fever with headache and myalgias, followed by rash 3 to 5 days later. The undifferentiated nature of clinical symptoms, knowledge of the epidemiology, and the patient's history of travel and exposure to arthropod vectors are critical to the empiric administration of antimicrobial therapy...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457355/chikungunya-virus
#3
REVIEW
David M Vu, Donald Jungkind, Angelle Desiree LaBeaud
For chikungunya virus (CHIKV), the long-term sequelae from infection are yet ill-defined. The prolonged debilitating arthralgia associated with CHIKV infection has tremendous potential for impacting the global economy and should be considered when evaluating the human burden of disease and the allocation of resources. There is much still unknown about CHIKV and the illnesses that it causes. Developing a better understanding of the pathogenesis of CHIKV infection is a priority and forms the basis for developing effective strategies at infection prevention and disease control...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457354/clostridium-difficile
#4
REVIEW
Scott R Curry
Clostridium difficile infections (CDIs) have emerged as one of the principal threats to the health of hospitalized and immunocompromised patients. The importance of C difficile colonization is increasingly recognized not only as a source for false-positive clinical testing but also as a source of new infections within hospitals and other health care environments. In the last five years, several new treatment strategies that capitalize on the increasing understanding of the altered microbiome and host defenses in patients with CDI have completed clinical trials, including fecal microbiota transplantation...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457353/tick-borne-emerging-infections-ehrlichiosis-and-anaplasmosis
#5
REVIEW
Nahed Ismail, Jere W McBride
Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457352/carbapenem-resistant-enterobacteriaceae
#6
REVIEW
Alina Iovleva, Yohei Doi
Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a major threat. Commonly used antibiotics are generally inactive against CRE. Therefore, timely detection of CRE is of paramount importance. Among CRE, those producing carbapenem-hydrolyzing β-lactamase enzymes (carbapenemase-producing Enterobacteriaceae) are particularly of concern because they tend to spread, and treatment is difficult. The carbapenemase groups most commonly encountered include KPC, NDM, and OXA-48. Treatment options are limited and include combinations of polymyxins, tigecycline, aminoglycosides, or carbapenems; newer agents with activity against CRE and better safety profiles are becoming available and will likely emerge as the preferred therapy...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457351/rift-valley-fever
#7
REVIEW
Amy Hartman
Rift Valley fever (RVF) is a severe veterinary disease of livestock that also causes moderate to severe illness in people. The life cycle of RVF is complex and involves mosquitoes, livestock, people, and the environment. RVF virus is transmitted from either mosquitoes or farm animals to humans, but is generally not transmitted from person to person. People can develop different diseases after infection, including febrile illness, ocular disease, hemorrhagic fever, or encephalitis. There is a significant risk for emergence of RVF into new locations, which would affect human health and livestock industries...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457350/ebola-virus-disease-an-update-on-epidemiology-symptoms-laboratory-findings-diagnostic-issues-and-infection-prevention-and-control-issues-for-laboratory-professionals
#8
REVIEW
Colin S Brown, Stephen Mepham, Robert J Shorten
The 2014 to 2016 Ebola virus disease (EVD), through the sheer size of the outbreak and combined experience within both resource-rich and resource-poor settings, allowed for more information to be gained about the clinical and pathologic features of EVD. This review highlights the range of aspects of EVD that the authors find are relevant to laboratory medicine, including the need for robust prediagnostic and laboratory processing algorithms to inform sampling of suspect patients, the vast majority of whom, in resource-rich settings, will have another diagnosis...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457349/zika-virus
#9
REVIEW
Ryan F Relich, Michael Loeffelholz
The ongoing epidemic of Zika fever in the Western Hemisphere has drawn considerable attention from the medical and scientific communities as well as the general public, largely because of its association with birth defects and postinfectious sequelae. Since its appearance in Brazil in 2015, Zika virus has spread to more than 45 countries in the Western Hemisphere and has caused countless infections. To date, no treatment or vaccine exists, but a considerable multinational effort to halt Zika virus transmission is underway...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28457348/west-nile-virus
#10
REVIEW
Vandana Saxena, Bethany G Bolling, Tian Wang
No abstract text is available yet for this article.
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153374/preface
#11
EDITORIAL
James O Westgard, David Armbruster, Sten A Westgard
No abstract text is available yet for this article.
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153373/sigma-metrics-across-the-total-testing-process
#12
REVIEW
Navapun Charuruks
Laboratory quality control has been developed for several decades to ensure patients' safety, from a statistical quality control focus on the analytical phase to total laboratory processes. The sigma concept provides a convenient way to quantify the number of errors in extra-analytical and analytical phases through the defect per million and sigma metric equation. Participation in a sigma verification program can be a convenient way to monitor analytical performance continuous quality improvement. Improvement of sigma-scale performance has been shown from our data...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153372/six-sigma-quality-management-system-and-design-of-risk-based-statistical-quality-control
#13
REVIEW
James O Westgard, Sten A Westgard
Six sigma concepts provide a quality management system (QMS) with many useful tools for managing quality in medical laboratories. This Six Sigma QMS is driven by the quality required for the intended use of a test. The most useful form for this quality requirement is the allowable total error. Calculation of a sigma-metric provides the best predictor of risk for an analytical examination process, as well as a design parameter for selecting the statistical quality control (SQC) procedure necessary to detect medically important errors...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153371/state-of-the-art-approach-to-goal-setting
#14
REVIEW
Angel Salas, Carmen Ricós, Enrique Prada, Francisco Ramón, Jorge Morancho, Josep M Jou, Raquel Blazquez
Four external quality assurance programs combined their data to calculate the minimum acceptable quality specifications for laboratory testing. Other sources of quality specifications may be too stringent for the current market, or too lenient given the clinical demands on the test result, but these state-of-the-art goals may be practical and useful. Two main approaches were used: (1) defining the 95% percentile and comparing with other quality specifications, and (2) using an iterative approach to increase the quality specification until 90% of laboratories could achieve 75% of their results within the specification...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153370/understanding-the-use-of-sigma-metrics-in-hemoglobin-a1c-analysis
#15
REVIEW
Erna Lenters-Westra, Emma English
This study uses three unique data sets to show the state of the art of hemoglobin A1c (HbA1c) analyzers in a range of settings and compares their performance against the international guidance set by the International Federation of Clinical Chemistry and Laboratory Medicine task force for HbA1c standardization. The data are used to show the effect of tightening those criteria, and the study serves as a guide to the practical implementation of the sigma-metrics approach in a range of clinical settings.
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153369/biologic-variation-approach-to-daily-laboratory
#16
REVIEW
Carmen Ricós, Virtudes Álvarez, Joana Minchinela, Pilar Fernández-Calle, Carmen Perich, Beatriz Boned, Elisabet González, Margarita Simón, Jorge Díaz-Garzón, José Vicente García-Lario, Fernando Cava, Pilar Fernández-Fernández, Zoraida Corte, Carmen Biosca
Biological variation gives valuable information about how the living organism regulates its constituents within and between subjects; this information on the behavior of body components allows us to derive consequences concerning reference populations and intervals. With a more pragmatic approach biological variation has three uses: setting the appropriate analytical performance specification for each analyte to limit the amount of error that laboratory could introduce in its measurements, to help distinguish health from disease, and to implement internal quality control with the automatic verification of results...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153368/rhetoric-versus-reality-laboratory-surveys-show-actual-practice-differs-considerably-from-proposed-models-and-mandated-calculations
#17
REVIEW
Sten A Westgard
The scientific debate on goals, measurement uncertainty, and individualized quality control plans has diverged significantly from the reality of laboratory operation. Academic articles promoting certain approaches are being ignored; laboratories may be in compliance with new regulations, mandates, and calculations, but most of them still adhere to traditional quality management practices. Despite a considerable effort to enforce measurement uncertainty and eliminate or discredit allowable total error, laboratories continue to use these older, more practical approaches for quality management...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153367/using-sigma-quality-control-to-verify-and-monitor-performance-in-a-multi-instrument-multisite-integrated-health-care-network
#18
REVIEW
Harold H Harrison, Jay B Jones
The authors developed a system-wide integrated network of instrumentation and Sigma-based quality control for fundamental chemistry, coagulation, and hematology analysis. The authors have based selection of Westgard rules for run management on a straightforward, Sigma-driven selection process. The network includes multiple hospitals and large regional clinic laboratories. Most hospitals have multiple instruments; overall there are at least four distinct instrument models active from each manufacturer. The authors have measured and monitored Sigma values in this network for more than five years, to verify and validate performance and to provide ongoing justification for rules selection and rules changes when necessary...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153366/quality-indicators-for-the-total-testing-process
#19
REVIEW
Mario Plebani, Laura Sciacovelli, Ada Aita
ISO 15189:2012 requires the use of quality indicators (QIs) to monitor and evaluate all steps of the total testing process, but several difficulties dissuade laboratories from effective and continuous use of QIs in routine practice. An International Federation of Clinical Chemistry and Laboratory Medicine working group addressed this problem and implemented a project to develop a model of QIs to be used in clinical laboratories worldwide to monitor and evaluate all steps of the total testing process, and decrease error rates and improve patient services in laboratory testing...
March 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28153365/applying-sigma-metrics-to-reduce-outliers
#20
REVIEW
Joseph Litten
Sigma metrics can be used to predict assay quality, allowing easy comparison of instrument quality and predicting which tests will require minimal quality control (QC) rules to monitor the performance of the method. A Six Sigma QC program can result in fewer controls and fewer QC failures for methods with a sigma metric of 5 or better. The higher the number of methods with a sigma metric of 5 or better, the lower the costs for reagents, supplies, and control material required to monitor the performance of the methods...
March 2017: Clinics in Laboratory Medicine
journal
journal
28065
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"