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Human Immunology

Zhendong Zhu, Jiyun Ye, Yumei Ma, Peng Hua, Yu Huang, Xuemei Fu, Dexuan Li, Maogen Yuan, Zhonghua Xia
T regulatory type 1 (Tr1) cells can promote tolerance and suppress inflammation. Atherosclerosis may be induced by the proinflammatory activation of cells in the vasculature and the immune system. Hence, we wondered whether defects in Tr1 function were a contributing factor to coronary artery disease (CAD). Data showed that the frequency of IL-10+ Tr1 cells was significantly lower in CAD patients than in controls. Compared to healthy controls, Tr1 cells from CAD patients presented lower CTLA-4 but higher PD-1 expression, in addition to lower IL-10 secretion...
May 3, 2018: Human Immunology
Antonio Arnaiz-Villena, Jose Palacio-Grüber, Ester Muñiz, Ennio Hernández, Brayan Bayona, Cristina Campos, Jorge Nuñez, AdrianLopez-Nares, Manuel Martin-Villa, Carlos Silvera
We have studied Wiwa/Sanja Amerindians HLA-A,-B,-C.-DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from "El Encanto" town at Guanachacariverside.Highfrequency alleles were in general present in other Amerindian populetions.Also,three extended haplotypes and eight ones were respectively both "new found" and already described in Amerindians from North,Central and South America,including Lakota-Sioux,Mayas,Teeneks,Quechua and Aymaras.Analyses of HLA-A∗24:02 and -C∗01:02 Wiwa high frequency alleles suggested a specific relatedness with another Amerindian and Pacific Islander ethnic groups (these two particular alleles bearing in high frequencies);they include New Zealand Maoris,Taiwanese,Japanese,Papua New Guinea,and Samoans among others...
May 2, 2018: Human Immunology
Lian Lopes Troncoso, Alessandra Pontillo, Enedina Maria Lobato de Oliveira, Alessandro Finkelszteijn, Silvete Schneider, José Artur Bogo Chies
BACKGROUND: Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migration and cytokine release in the CNS, and it was demonstrated to strongly contribute to CNS inflammation and damage in several models of sterile and pathogen-mediated CNS diseases. Although the inhibition of CCR5 results in a beneficial effect in experimental models of MS, conflicting results have been found about the loss-of-function variant CCR5Δ32 (rs333) in MS patients...
May 2, 2018: Human Immunology
Divya Sai Katikaneni, Lei Jin
MHC class II regulates B cell activation, proliferation, and differentiation during cognate B cell -T cell interaction. This is, in part, due to the MHC class II signaling in B cells. Activation of MHC Class II in human B cells or "primed" murine B cells leads to tyrosine phosphorylation, calcium mobilization, AKT, ERK, JNK activation. In addition, crosslinking MHC class II with monoclonal Abs kill malignant human B cells. Several humanized anti-HLA-DR/MHC class II monoclonal Abs entered clinical trials for lymphoma/leukemia and MHC class II-expressing melanomas...
April 28, 2018: Human Immunology
Nicolas Vince, Gaël Mouillot, Marion Malphettes, Sophie Limou, David Boutboul, Angélique Guignet, Véronique Bertrand, Philippe Pellet, Pierre-Antoine Gourraud, Patrice Debré, Eric Oksenhendler, Ioannis Théodorou, Claire Fieschi
The precise diagnosis of an immunodeficiency is sometimes difficult to assess, especially due to the large spectrum of phenotypic variation reported among patients. Common variable immunodeficiency disorders (CVID) do not have, for a large part, an identified genetic cause. The identification of a causal genetic mutation is important to confirm, or in some cases correct, the diagnosis. We screened >150 male patients with hypogammaglobulinemia for mutations in three genes involved in pediatric X-linked primary immunoglobulin deficiency: CD40LG, SH2D1A and BTK...
April 27, 2018: Human Immunology
Carolyn Katovich Hurley, Jennifer Ng
Next generation DNA sequencing has facilitated the routine characterization of complete HLA gene sequences. These data complement structural and functional studies of HLA elements encoded outside of the exons specifying the antigen recognition domain. This commentary is focused on evaluating whether the interpretation of HLA clinical typing results should expand the region of the HLA gene considered in the assignment from the exon(s) encoding the antigen recognition domain to the full gene sequence. Our recommendation is that, at present, there is insufficient data to support considering variation in the regions outside of the antigen recognition domain in clinical decision making...
April 20, 2018: Human Immunology
A Fleury, C Alaez, A Dessein, M Rosetti, B Saenz, M Hernández, R J Bobes, R Aquino, E Sciutto, C Gorodezky, G Fragoso
Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While the factors involved in this heterogeneity are not completely understood, clearly different immune-inflammatory profiles have been associated to each condition. This study evaluated the association of cytokine single nucleotide polymorphisms (SNPs) with susceptibility to infection and disease severity in NC patients...
April 20, 2018: Human Immunology
Asgeir Lande, Irene Andersen, Torstein Egeland, Benedicte A Lie, Marte K Viken
We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel...
April 20, 2018: Human Immunology
Martina Koch, Matthias Marget, Martina Sterneck, Lutz Fischer, Hansjörg Thude, Björn Nashan
The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. To investigate the role of DSA in long term liver allograft survival we analysed 177 pre transplant sera of first LTx patients with luminex single antigen technology defining a MFI of >1500 as positive...
April 15, 2018: Human Immunology
Janette Kwok, Mengbiao Guo, Wanling Yang, Patrick Ip, C K Lee, Liwei Lu, Godfrey C F Chan, Derek Middleton, Henk G M van der Zanden
In Cord blood transplantation (CBT), the non-inherited maternal antigen (NIMA) virtual six HLA matched CB is found to have similar outcomes to six HLA inherited matched CB. Such virtual HLA matched CB units can be generated by substituting the inherited alleles with one to three NIMAs. In Hong Kong Cord Blood Bank, CB units have no NIMA defined. 100 CB samples were collected with NIMA defined. Retrospective searches of Hong Kong patients (n = 520) were matched against the inherited and virtual HLA phenotypes of NIMA CB file...
April 13, 2018: Human Immunology
Ann M Moyer, Shahrukh K Hashmi, Cynthia Kroning, Steven R De Goey, Mrinal Patnaik, Mark Litzow, Dennis A Gastineau, William J Hogan, Eapen K Jacob, Justin D Kreuter, Laurie L Wakefield, Manish J Gandhi
BACKGROUND: Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes. METHODS: The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease...
April 13, 2018: Human Immunology
Steven G E Marsh
No abstract text is available yet for this article.
April 13, 2018: Human Immunology
Steven G E Marsh
No abstract text is available yet for this article.
April 13, 2018: Human Immunology
Steven G E Marsh
No abstract text is available yet for this article.
April 13, 2018: Human Immunology
Patricia Cristina Grenzi, Érika Fernandes Campos, Hélio Tedesco-Silva, Claudia Rosso Felipe, Maria Fernanda Soares, José Medina-Pestana, Hinrich Peter Hansen, Maria Gerbase-DeLima
BACKGROUND: Soluble CD30 (sCD30) is a suggested marker for kidney transplantation outcomes. We investigated whether sCD30 serum levels are influenced by immunosuppression and whether they correlate with findings in protocol biopsies and with CD30 gene expression in peripheral blood mononuclear cells (PBMC). METHODS: We studied 118 kidney transplant recipients that initially received tacrolimus (TAC) and, at month-3, were converted or not to sirolimus (SRL). RESULTS: sCD30 serum levels gradually declined after transplantation, being the decline more pronounced in the SRL group...
April 12, 2018: Human Immunology
Smriti Kanangat, Christopher W Seder, Melissa R Pergande, Gabriela C Lobato, Cristina L Fhied, Maryam F Raouf, Michael J Liptay, Jeffrey A Borgia
BACKGROUND: This study explores the potential diagnostic utility of soluble Human Leukocyte Antigen (sHLA) molecules differentially released by lung adenocarcinoma and benign lung lesions. METHODS: Conditioned media from the NSCLC cell lines H358 and H1703 were immunoblotted for soluble isoforms of major histocompatibility complex (MHC) class I (ABC) and II (DRB1, DMB, and DQ) antigens. Sera from 25 patients with benign and 25 patients with malignant lesions were similarly evaluated to appraise the potential diagnostic value...
April 12, 2018: Human Immunology
Jessica L Spruit, Omar R Fagoaga, Süreyya Savaşan
Cerebrospinal fluid (CSF) cell count, morphology and flow cytometric evaluations are used to investigate central nervous system (CNS) involvement in leukemia/lymphoma. We performed CSF short tandem repeat (STR) analysis to monitor CSF chimerism status and evaluate for disease involvement in 11 asymptomatic pediatric allogeneic hematopoietic stem cell transplantation (HSCT) recipients with hemato-lymphoid neoplasms and high risk for or history of CNS involvement. Eighteen (64%) of the samples with median CSF cell count of 1/mm3 with 90% lymphocytes gave conclusive STR results, suggesting that this DNA-based method can be used in monitoring CSF chimerism status after HSCT with an acceptable yield...
April 11, 2018: Human Immunology
Jin-Huan Cui, Ya-Bin Jin, Kai-Rong Lin, Ping Xiao, Xiang-Ping Chen, Ying-Ming Pan, Wei Lin, Zu-Chang Wu, Dong-Mei Guo, Xiao-Fan Mao, Chu-Ling Zhang, Wen-Lue Lian, Wei Luo
Ankylosing spondylitis (AS) is a chronic and progressive autoimmune disease affecting the invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the underlying pathogenesis of AS, which mediated autoimmune and inflammatory responses via specific recognition of autoantigen peptides presented by susceptibility HLA. Antigen-specific T cells triggered by HLA/antigen complexes will undergo a massive expansion that forming an uneven T cell repertoire. To enhance our understanding of T-cell-mediated autoimmune in AS, we applied TCR β chains high-throughput sequencing to AS patients for in-depth TCR repertoire analysis...
March 31, 2018: Human Immunology
Takayuki Yamamoto, Kenta Iwasaki, Kenta Murotani, Asami Takeda, Kenta Futamura, Manabu Okada, Makoto Tsujita, Takahisa Hiramitsu, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Kunio Morozumi, Kazuharu Uchida, Takaaki Kobayashi
Noninvasive methods for the early diagnosis of chronic antibody-mediated rejection (cAMR) are desired for patients with de novo (dn) donor-specific HLA antibody (DSA). This study aimed to elucidate the clinical relevance of immune-related gene expression in peripheral blood of kidney transplant recipients. The expression levels of fourteen key molecules (Foxp3, CTLA-4, CCR7, TGF-β, IGLL-1, IL-10, ITCH, CBLB, Bcl-6, CXCR5, granzyme B, CIITA, Baff, TOAG-1/TCAIM) related to regulatory/cytotoxic function of immune cells were compared in 93 patients, which were divided into Groups A (clinical cAMR with dn DSA, n=16), B (subclinical cAMR with dn DSA, n=17), C (negative cAMR with dn DSA, n=21) and D (stable function without dn DSA, n=39)...
March 31, 2018: Human Immunology
Rocío Aguado, Aurora Páez-Vega, María L Agüera, Miguel Montejo, Lluis Guirado, Jesús Fortún, Alejandro Suárez-Benjumea, Oscar Len, María C Fariñas, Carmen de Gracia, Domingo Hernández, María J Cobos-Ceballos, Julián Torre-Cisneros, Sara Cantisán
The aim of this study was to analyze the relationship between the IFNG+874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant patients (108 kidney, 68 liver and 8 lung) were recruited. Of them, 151 patients were QF-CMV Reactive (IFNG ≥0.2 UI/mL) and 33 were Non-reactive. Genotype frequencies in the study population were TT (26...
March 29, 2018: Human Immunology
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