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Human Immunology

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https://www.readbyqxmd.com/read/27894836/use-of-complement-binding-assays-to-assess-the-efficacy-of-antibody-mediated-rejection-therapy-and-prediction-of-graft-survival-in-kidney-transplantation
#1
Daniel S Ramon, Yihung Huang, Lili Zhao, TrisAnn Rendulic, Jeong M Park, Randall S Sung, Milagros Samaniego
BACKGROUND: The Luminex® single antigen bead assay (SAB) is the method of choice for monitoring the treatment for antibody-mediated rejection (AMR). A ⩾50% reduction of the dominant donor-specific antibody (IgG-DSA) mean fluorescence intensity (MFI) has been associated with improved kidney allograft survival, and C1q-fixing DSA activity is associated with poor outcomes in patients with AMR. We aimed to investigate if C1q-DSA can be used as a reliable predictor of response to therapy and allograft survival in patients with biopsy-proven AMR...
November 25, 2016: Human Immunology
https://www.readbyqxmd.com/read/27890719/casting-a-smaller-net-into-a-bigger-donor-pool-a-single-center-s-experience-with-the-new-kidney-allocation-system
#2
Julie A Houp, Karl P Schillinger, Andrew J Eckstein, Renato M Vega, Niraj M Desai, Bonnie E Lonze, Annette M Jackson
The new kidney allocation system (KAS) provides additional allocation points for candidates with broad HLA sensitization in an effort to increase transplant rates for this underserved population. Following the implementation of KAS, our center lowered the HLA antibody threshold for listing unacceptable antigens from a cytotoxicity crossmatch level to a flow cytometric crossmatch level increasing Calculated Panel Reactive Antibody (CPRA) values and allocation points, yet restricting acceptable donor HLA phenotypes...
November 24, 2016: Human Immunology
https://www.readbyqxmd.com/read/27888068/associations-of-single-nucleotide-polymorphisms-of-ptpn22-and-ctla4-genes-with-the-risk-of-allergic-rhinitis-in-a-chinese-han-population
#3
Xia Ke, Shanghua Song, Xiaoqiang Wang, Yang Shen, Houyong Kang, Suling Hong
BACKGROUND: Allergic rhinitis (AR) is an inflammatory disorder of the upper airway. Protein tyrosine phosphatase non-receptor 22 encoded by PTPN22 gene and cytotoxic T-lymphocyte associated 4 encoded by Ctla4 gene are associated with autoimmune diseases. PURPOSE: This study was performed to evaluate the potential association of PTPN22 and Ctla4 single nucleotide polymorphisms (SNPs) with AR in a Chinese Han population. METHODS: A case-control study was performed in 783 Chinese AR patients and 811 healthy controls...
November 22, 2016: Human Immunology
https://www.readbyqxmd.com/read/27888067/allele-and-genotype-frequencies-of-polymorphisms-in-cytokine-genes-in-ethnic-russian-individuals-from-moscow-russia
#4
Alexandra Shadrina, Elena Voronina, Igor Zolotukhin, Maxim Filipenko
Two hundred and twenty eight ethnic Russian individuals from Moscow, Russia, were genotyped at 14 single nucleotide polymorphisms CCL2 A-2578G; VEGFA C-2578A, G-634C, and C+936T; TNF G+419A and G-308A; IL1A G-889A; IL1RN T+1018C; IL6 G-174C and G-572C; IFNG T+874A; IL1B C-511T; IL10 A+1082G; TGFB1 C-509T. Genotypes were determined using real-time polymerase chain reaction with TaqMan probes and polymerase chain reaction followed by melting analysis of dual-labeled probe. Genotype distribution was in accordance with Hardy-Weinberg equilibrium for all studied polymorphisms...
November 22, 2016: Human Immunology
https://www.readbyqxmd.com/read/27884732/natural-killer-cell-subsets-and-receptor-expression-in-peripheral-blood-mononuclear-cells-of-a-healthy-korean-population-reference-range-influence-of-age-and-sex-and-correlation-between-nk-cell-receptors-and-cytotoxicity
#5
Minh-Trang Phan, Sejong Chun, Sun-Hee Kim, Alaa Kassim Ali, Seung-Hwan Lee, Seokho Kim, Soo-Hyun Kim, Duck Cho
BACKGROUND: The purpose of this study was to identify CD56(bright) and CD56(dim) natural killer (NK) cell subsets and analyze their receptors expression in a healthy Korean population, and to determine whether receptor expression correlates with age, sex, and cytotoxicity. MATERIALS AND METHODS: We performed multicolor flow cytometry assays to analyze the expression of various NK cell receptors (CD16, NKG2A, NKG2C, NKG2D, CD57, DNAM-1, CD8a, CD62L, NKp30, and NKp46) on both CD3(-)/CD56(dim) and CD3(-)/CD56(bright) NK cells in whole-blood samples from 122 healthy donors...
November 21, 2016: Human Immunology
https://www.readbyqxmd.com/read/27866840/the-role-of-human-leukocyte-antigen-drb1-dqb1-haplotypes-in-the-susceptibility-to-acquired-idiopathic-thrombotic-thrombocytopenic-purpura
#6
György Sinkovits, Ágnes Szilágyi, Péter Farkas, Dóra Inotai, Anikó Szilvási, Attila Tordai, Katalin Rázsó, Marienn Réti, Zoltán Prohászka
The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of antibodies. The loci coding HLA DR and DQ molecules are inherited in linkage as haplotypes. The c.1858C>T polymorphism of the PTPN22 gene, which codes a protein tyrosine phosphatase important in lymphocyte activation, predisposes to a number of autoimmune diseases...
November 17, 2016: Human Immunology
https://www.readbyqxmd.com/read/27864154/root-cause-analysis-of-limitations-of-virtual-crossmatch-for-kidney-allocation-to-highly-sensitized-patients
#7
Vivek Jani, Elizabeth Ingulli, Kristen Mekeel, Gerald P Morris
Efficient allocation of deceased donor organs depends upon effective prediction of immunologic compatibility based on donor HLA genotype and recipient alloantibody profile, referred to as virtual crossmatching (VCXM). VCXM has demonstrated utility in predicting compatibility, though there is reduced efficacy for patients highly sensitized against allogeneic HLA antigens. The recently revised deceased donor kidney allocation system (KAS) has increased transplantation for this group, but with an increased burden for histocompatibility testing and organ sharing...
November 15, 2016: Human Immunology
https://www.readbyqxmd.com/read/27845172/the-new-kas-challenges-and-opportunities
#8
EDITORIAL
Howard M Gebell, Malek Kamounb
No abstract text is available yet for this article.
November 12, 2016: Human Immunology
https://www.readbyqxmd.com/read/27845171/the-new-kas-it-takes-a-village
#9
EDITORIAL
Howard M Gebel, Malek Kamoun
No abstract text is available yet for this article.
November 11, 2016: Human Immunology
https://www.readbyqxmd.com/read/27840088/hla-compatibility-assessment-and-management-of-highly-sensitized-patients-under-the-new-kidney-allocation-system-kas-a-2016-status-report-from-twelve-hla-laboratories-across-the-u-s
#10
M Kamoun, D Phelan, H Noreen, N Marcus, L Klingman, H M Gebel
Twelve HLA laboratories were surveyed to assess the methods and operational issues involved to define highly sensitized patients and to assess HLA compatibility under the new kidney allocation system (KAS) in the U.S. All laboratories used single antigen bead assays both pre- and post-KAS to define both broad and allele-specific HLA antibodies. The methods and threshold used to list HLA unacceptable antigens in UNet for virtual crossmatch (vXM) and the criteria used for determining HLA compatibility varied among laboratories...
November 10, 2016: Human Immunology
https://www.readbyqxmd.com/read/27838362/impact-of-tnf-%C3%AE-and-lt%C3%AE-gene-polymorphisms-on-genetic-susceptibility-in-indian-sle-patients
#11
Vinod D Umare, Vandana D Pradhan, Anjali G Rajadhyaksha, Manisha M Patwardhan, Kanjaksha Ghosh, Anita H Nadkarni
The promoter polymorphisms of tumour necrosis factor-α (TNF-α) and intronic Lymphotoxin-α (LTα) have been implicated as genetic risk factors for systemic lupus erythematosus (SLE) in various ethnic groups. The aim of this study was to investigate an impact of TNF-α (-308G/A; 238G/A) and LTα (+252A/G) gene polymorphisms in disease susceptibility among Indian 200 SLE patients along with 201 healthy controls. The gene polymorphisms were studied by using direct DNA sequencing and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methods...
November 9, 2016: Human Immunology
https://www.readbyqxmd.com/read/27818166/new-priorities-analysis-of-the-new-kidney-allocation-system-on-ucla-patients-transplanted-from-the-deceased-donor-waitlist
#12
Michelle J Hickey, Ying Zheng, Nicole Valenzuela, Qiuheng Zhang, Carolyn Krystal, Erik Lum, Eileen W Tsai, Gerald S Lipshutz, H Albin Gritsch, Gabriel Danovitch, Jeffrey Veale, David Gjertson, Michael Cecka, Elaine F Reed
UNOS implemented a new kidney allocation system (New KAS) on December 4, 2014 with a primary goal of increasing equity to organ transplant for patients that were immunologically or socially disadvantaged by the previous allocation system (Previous KAS) that prioritized long wait times. We examined the effects of the New KAS on patients transplanted from the UCLA deceased donor waitlist during the first year and compared to the last year of the Previous KAS. The total number of deceased donor kidney transplants was increased in the New KAS as compared to the Previous KAS (178 vs 148)...
November 3, 2016: Human Immunology
https://www.readbyqxmd.com/read/27816498/increased-expression-of-tipe2-mrna-in-pbmcs-of-patients-with-ankylosing-spondylitis-is-negatively-associated-with-the-disease-severity
#13
Peiqing Zhao, Lianqing Wang, Xinxin Xiang, Xiaowei Zhang, Qiaoli Zhai, Xifa Wu, Tao Li
Ankylosing spondylitis (AS) is an autoimmune disease and characterized by chronic inflammatory arthritis. Tumor necrosis factor α induced protein-8 like-2 (TIPE2) is responsible for maintaining immune homeostasis by inhibiting the secretion of inflammatory cytokines in the condition of inflammation. However, whether TIPE2 participates in the development of AS remains unknown. In this study, we measured the mRNA expression of TIPE2 and TIPE1 in peripheral blood mononuclear cells (PBMCs) from 45 AS patients and 40 healthy controls by qRT-PCR...
November 2, 2016: Human Immunology
https://www.readbyqxmd.com/read/27810496/common-phenotype-and-different-non-hla-genes-in-graves-disease-and-alopecia-areata
#14
Yasunori Taketomo, Shinsuke Noso, Naru Babaya, Yoshihisa Hiromine, Hiroyuki Ito, Kousei Kanto, Fumimaru Niwano, Naoki Oiso, Akira Kawada, Yumiko Kawabata, Hiroshi Ikegami
Our previous observations clarified that Graves' disease (GD) is the most frequent autoimmune disease in patients with alopecia areata (AA), and 42.7% of patients with AA were positive for thyrotropin receptor antibody (TRAb). A class II HLA haplotype DRB1∗15:01-DQB1∗06:02 was suggested to contribute to autoimmunity against the thyroid gland in AA. To further clarify the genetic factors contributing to organ specificity in autoimmune diseases, we studied the contribution of non-HLA genes to organ specificity in GD and AA...
October 31, 2016: Human Immunology
https://www.readbyqxmd.com/read/27810495/psoriasis-risk-snps-and-their-association-with-hiv-1-control
#15
Joanne Nititham, Rashmi Gupta, Xue Zeng, Wendy Hartogensis, Douglas F Nixon, Steven G Deeks, Frederick M Hecht, Wilson Liao
Human evolution has resulted in selection for genetic polymorphisms beneficial in the defense against pathogens. However, such polymorphisms may have the potential to heighten the risk of autoimmune disease. Here, we investigated whether psoriasis-associated single nucleotide polymorphisms influence host control of HIV-1 infection. We studied psoriasis and viral immune response variants in three HIV-positive cohorts: (1) HIV-1 controllers and non-controllers in the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort (n=366), (2) Individuals with primary HIV infection in the Options cohort (n=675), and (3) HIV-positive injection drug users from the Urban Health Study (UHS) (n=987)...
October 31, 2016: Human Immunology
https://www.readbyqxmd.com/read/27793650/interleukin-10-gene-single-nucleotide-polymorphisms-in-polish-patients-with-chronic-hepatitis-c-analysis-of-association-with-severity-of-disease-and-treatment-outcome
#16
Bogna Świątek-Kościelna, Ewelina Kałużna, Ewa Strauss, Danuta Januszkiewicz-Lewandowska, Iwona Bereszyńska, Jacek Wysocki, Jolanta Rembowska, Dominika Barcińska, Dariusz Antosik, Iwona Mozer-Lisewska, Jerzy Nowak
It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nucleotide polymorphisms (SNPs) of IL-10 gene with severity of liver disease (degree of inflammation and stage of fibrosis) and outcome of pegylated interferon alpha and ribavirin combined therapy (sustained virological response (SVR) and relapse) in 196 Polish CHC patients infected with HCV genotype 1...
October 25, 2016: Human Immunology
https://www.readbyqxmd.com/read/27780790/association-between-hla-genes-and-dust-mite-sensitivity-in-a-brazilian-population
#17
Marcela Caleffi da Costa Lima Caniatti, Sueli Donizete Borelli, Ana Lúcia Falavigna Guilherme, Luiza Tamie Tsuneto
BACKGROUND: Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic asthma and rhinitis. OBJECTIVE: This study aimed to investigate the association between HLA class I (-A, -B, and -C), and HLA class II (-DRB1) genes in individuals sensitive to dust mites (Dermatophagoides farinae, Dermatophagoides pteronyssinus, or Blomia tropicalis) and mite-insensitive controls...
October 22, 2016: Human Immunology
https://www.readbyqxmd.com/read/27773831/kidney-transplantation-of-highly-sensitized-recipients-under-the-new-kidney-allocation-system-a-reflection-from-five-different-transplant-centers-across-the-united-states
#18
Ronald F Parsons, Jayme E Locke, Robert R Redfield, Garrett R Roll, Matthew H Levine
Deceased donor kidney allocation was reorganized in the United States to address several problems, including the highly sensitized patients disadvantaged with large, diverse repertoires of antibodies. Here, five transplant surgeons review their center's experience with the new allocation changes: highlighting areas of accomplishment, opportunities for improvement and, in some cases, stark differences in practice. Across these five centers the highly sensitized patients (CPRA ⩾98%) range from 5.5 to 9.2% of the 12,364 candidates on their collective waitlist...
October 20, 2016: Human Immunology
https://www.readbyqxmd.com/read/27771385/should-epitope-based-hla-compatibility-be-used-in-the-kidney-allocation-system
#19
Rene J Duquesnoy
The new kidney allocation system (KAS) still applies donor-recipient HLA compatibility mostly at the antigen level and although some four-digit alleles have been included. This system is used to record unacceptable mismatches for sensitized transplant candidates with serum HLA antibodies. Since the reactivities of such antibodies are specifically associated with epitopes rather than HLA antigens, a more scientifically accurate assessment of mismatch acceptability could be based on epitopes. HLA class I and class II epitope specificity analyses can now be readily performed with serum antibody assays with single allele panels...
October 19, 2016: Human Immunology
https://www.readbyqxmd.com/read/27771384/the-new-kidney-allocation-system-does-not-equally-advantage-all-very-high-cpra-candidates-a-single-center-analysis
#20
Amy B Hahn, Maryanne Mackey, Don Constantino, Ashar Ata, Nikolaos Chandolias, Reynold Lopez-Soler, David J Conti
The new UNOS kidney allocation system awards very high points to candidates with cPRA 99% and 100%, and allows for national sharing for cPRA 100% candidates. We sought to determine the effect of this new kidney allocation system on candidates who are very highly sensitized (90-98% cPRA) but not eligible for very high points or national sharing by examining offers to these candidates for 5months pre-implementation and two consecutive 5month periods post-implementation and comparing them to cPRA⩾99% candidates...
October 19, 2016: Human Immunology
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