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Human Immunology

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https://www.readbyqxmd.com/read/28442289/hla-a-b-and-c-allele-and-haplotype-frequencies-defined-by-next-generation-sequencing-in-a-population-of-519-english-blood-donors
#1
Sue Davey, John Ord, Cristina Navarrete, Colin Brown
Whole gene next generation sequencing was used to determine the HLA class I haplotype and allele frequencies in a cohort of 519 English blood donors. This is the first report of HLA frequencies at third field resolution in a UK population with a total of 33, 52 and 30 alleles identified for HLA-A, -B and -C, respectively. Of the 1411 haplotypes determined, 281 had a frequency of greater than 0.05%. Data are available from the Allele Frequencies Net Database under the population name 'England Blood Donors of Mixed Ethnicity', identifier 3392...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28442288/expression-and-differential-regulation-of-hla-g-isoforms-in-the-retinal-pigment-epithelial-cell-line-arpe-19
#2
Signe Goul Svendsen, Maja Søberg Udsen, Marina Daouya, Tina Funck, Ching-Lien Wu, Edgardo D Carosella, Joël LeMaoult, Thomas Vauvert F Hviid, Carsten Faber, Mogens Holst Nissen
The purpose of this study was to examine if HLA-G is expressed in the retinal pigment epithelium (RPE) cells of the eye. The RPE comprises the outer most layer of the retina and as such defines the interface to the blood and contributes to the immune privilege in the posterior part of the eye. One way the RPE might be regulating the immune system could be by expressing the non-classical human leukocyte antigen (HLA) molecule, HLA-G. We therefore sought to define if the RPE cell line, ARPE-19, expressed HLA-G and analyse the regulation as a response to pro-inflammatory cytokines...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28442287/hla-a-b-drb1-allele-and-haplotype-frequencies-of-674-cord-blood-donors-from-north-italy
#3
C Capittini, A De Silvestri, M Guarene, A Pasi, C Tinelli, C Perotti
No abstract text is available yet for this article.
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28438554/interleukin-17f-and-interleukin-6-gene-polymorphisms-in-asian-indian-patients-with-takayasu-arteritis
#4
Debashish Danda, Ruchika Goel, Sumita Danda, Hindhumathi Mohan, George Joseph, Jayakanthan Kabeerdoss, Swapan K Nath
OBJECTIVES: To assess genetic association between single nucleotide polymorphisms (SNPs) in genes encoding T-helper cytokines and Takayasu Arteritis (TA) susceptibility in Indian population. METHODS: In Phase-1, the genomic DNA of 120 TA patients and 119 healthy controls were genotyped for SNPs rs1800795 (interleukin (IL)-6), rs763780 (IL-17F), rs1800871, rs1800872, rs1800896 (IL-10) and rs1800468, rs1800469, rs1800470 (transforming growth factor-β). Allele frequencies between cases and controls were compared using chi-squared test and also reassessed empirically (pe) by 10,000 permutations...
April 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28438553/human-leukocyte-antigen-class-i-a-b-and-c-allele-and-haplotype-variation-in-a-south-african-mixed-ancestry-population
#5
Shayne Loubser, Maria Paximadis, Caroline T Tiemessen
South Africa has a large (∼53 million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼365 years ago in the Western Cape region through interracial mixing of black Africans, Europeans and Asians. Admixed populations present unique opportunities to identify genetic factors involved in disease susceptibility...
April 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431960/nomenclature-for-factors-of-the-hla-system-update-march-2017
#6
Steven G E Marsh
No abstract text is available yet for this article.
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431959/nomenclature-for-factors-of-the-hla-system-update-february-2017
#7
Steven G E Marsh
No abstract text is available yet for this article.
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431958/nomenclature-for-factors-of-the-hla-system-update-january-2017
#8
G E Steven
No abstract text is available yet for this article.
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431957/genetic-study-of-kir-and-hla-ligands-in-235-individuals-from-northeastern-thailand
#9
Suwit Chaisri, Chanvit Leelayuwat, Amornrat Romphruk
The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP) method. The Hardy-Weinberg Equilibrium (HWE) was used to verify genotyping method for dimorphic KIR and HLA. They were in HWE (p>0.05). KIR and HLA ligands frequencies, genotypes, haplotypes and linkage disequilibrium (LD) were presented. The genetic data are available in allele Frequencies Net Database...
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28372986/assessing-the-potential-of-angiotensin-ii-type-1-receptor-and-donor-specific-anti-endothelial-cell-antibodies-to-predict-long-term-kidney-graft-outcome
#10
David F Pinelli, John J Friedewald, Kelley M K Haarberg, Shree L Radhakrishnan, Jennifer R Zitzner, Wendy Wegner, Anat R Tambur
Endothelial cell antigens have been reported as potential targets for antibodies in the context of organ transplantation, leading to increased risk for graft failure. Serum samples from 142 consecutive living donor kidney recipients were tested for the presence of antibodies to Angiotensin II - Type 1 Receptor (AT1R), donor endothelial cells, and donor HLA. Graft survival was monitored for five years post-transplant, and secondary outcomes, including biopsy-proven rejection, proteinuria, biopsy-proven vasculopathy, and renal function based on serum creatinine were also assessed for the first two to three years...
March 31, 2017: Human Immunology
https://www.readbyqxmd.com/read/28359736/hla-a-b-drb1-dqa1-dqb1-alleles-and-haplotype-frequencies-in-dene-and-cree-cohorts-in-manitoba-canada
#11
Linda A Larcombe, Leigh Anne Shafer, Peter W Nickerson, Andrew M Lodge, Jodie S Brown, Leisel C Milligan, Denise Pochinco, Lynnette Beaudin, Brian Arundel, Jacqueline Wong, Joe Dantouze, Lizette Denechezhe, Pamela H Orr
BACKGROUND: First Nations in the Canadian province of Manitoba have disproportionately high rates of epidemic and endemic TB. Gene polymorphisms that modulate HLA Class I and II antigens are among the risk markers for TB, along with other biologic, and social determinants of health. HLA-A, B, DRB1, DQA1, DQB1 were typed in two Manitoba First Nation indigenous groups to identify and compare the frequency of gene polymorphisms that may influence susceptibility or resistance to TB. METHODS: Participants who self-identified as either Dene or Cree enrolled into the study from two First Nation communities in Manitoba, Canada...
March 27, 2017: Human Immunology
https://www.readbyqxmd.com/read/28347702/cytokine-gene-polymorphisms-in-populations-from-parana-southern-brazil
#12
Pâmela Guimarães Reis, Josiane Bazzo de Alencar, Luciana Conci Macedo, Eliane Papa Ambrosio-Albuquerque, Julimary Suematsu de Aquino, Joana Maira Valentini Zacarias, Patrícia Yumeko Tsuneto, Ricardo Alberto Moliterno, Ana Maria Sell, Jeane Eliete Laguila Visentainer
In this study, were genotyped 22 single nucleotide polymorphisms (SNPs) in 13 genes that encode the pro-inflammatory (IL-1α, IL-1β, IL-1R, IL-4Rα, IL-12, IFN-γ, TNF-α, and IL-2) and anti-inflammatory (IL-1RA, TGF-β, IL-4, IL-6 and IL-10) cytokines of 350 individuals by PCR-SSP (polymerase chain reaction - sequence specific primer). A total of 473 individuals were genotyped for IL17A and IL17F genes by PCR-RFLP (restriction fragment length polymorphism). The sample consisted of healthy and unrelated subjects from a mixed population from Parana state, in the South region of Brazil...
March 25, 2017: Human Immunology
https://www.readbyqxmd.com/read/28341250/modulation-of-lilrb2-protein-and-mrna-expressions-in-septic-shock-patients-and-after-ex-vivo-lipopolysaccharide-stimulation
#13
Fabienne Venet, Jeremy Schilling, Marie-Angélique Cazalis, Julie Demaret, Fanny Poujol, Thibaut Girardot, Christelle Rouget, Alexandre Pachot, Alain Lepape, Arnaud Friggeri, Thomas Rimmelé, Guillaume Monneret, Julien Textoris
Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study, we identified LILRB2 as an upregulated gene in septic shock patients. On monocytes primed with LPS ex vivo, LILRB2 mRNA and protein expressions were dose-dependently downregulated and subsequently highly upregulated versus non-stimulated cells...
March 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28336310/regulatory-role-of-ccl5-rs2280789-and-cxcl10-rs56061981-gene-polymorphisms-on-intracellular-ccl5-and-cxcl10-expression-in-pulmonary-tuberculosis
#14
Brijendra Singh, Selvaraj Anbalagan, Paramasivam Selvaraj
Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellular CCL5 and CXCL10 expression in T cells. Whole blood cell cultures were stimulated with culture filtrate antigen (CFA) and infected with live M. tuberculosis were used for intracellular CCL5 and CXCL10 expression using flow cytometry...
March 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28336309/usefulness-of-the-ellipro-epitope-predictor-program-in-defining-the-repertoire-of-hla-abc-eplets
#15
Rene J Duquesnoy, Marilyn Marrari
HLA matching at the epitope level offers new opportunities to identify suitable donors for transplant patients. The International HLA Epitope Registry (www.Epregistry.com.br) describes for the various HLA loci, repertoires of eplets including those that correspond to epitopes experimentally verified with specific antibodies. There are also many eplets which have remained as theoretical entities because no informative antibodies have been found. Which of them have immunogenic potential or conversely, might be considered as non-epitopes that cannot elicit specific antibody responses? This question is important for the application of epitope-based HLA matching in clinical transplantation...
March 20, 2017: Human Immunology
https://www.readbyqxmd.com/read/28259733/nfkbiz-in-psoriasis-assessing-the-association-with-gene-polymorphisms-and-report-of-a-new-transcript-variant
#16
Pablo Coto-Segura, Leire Gonzalez-Lara, Juan Gómez, Noemí Eiris, Ana Batalla, Celia Gómez, Sheila Requena, Rubén Queiro, Belén Alonso, Sara Iglesias, Eliecer Coto
The IκBζ protein (NFKBIZ gene) is a nuclear inhibitor of NF-κB and plays an important role in the pathogenesis of Psoriasis (Psor). We sought to determine whether common NFKBIZ variants were associated with the risk of developing Psor. A total of 392 patients and 336 controls were genotyped for a common intron 10 indel that could affect pre-mRNA splicing. We found a significantly higher frequency of the insertion among the cw6-positive patients (p=0.01). Cw6-positive+intron 10 ins/ins were significantly more frequent in the patients (OR=3...
March 1, 2017: Human Immunology
https://www.readbyqxmd.com/read/28315719/sequence-based-hla-a-b-c-dp-dq-and-dr-typing-of-100-luo-infants-from-the-boro-area-of-nyanza-province-kenya
#17
Cecilia S Lindestam Arlehamn, Richard Copin, Shay Leary, Steven J Mack, Elizabeth Phillips, Simon Mallal, Alessandro Sette, Gretta Blatner, Heather Siefers, Joel D Ernst
One hundred healthy infants enrolled as controls in a tuberculosis vaccine study in Nyanza Province, Kenya provided anonymized samples for DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci. The purpose of the study was to characterize allele frequencies in the local population, to support studies of T cell immunity against pathogens, including Mycobacterium tuberculosis. There are no detectable deviations from Hardy Weinberg proportions for the HLA-B, -C, -DRB1, -DPB1, -DQA1 and -DQB1 loci...
April 2017: Human Immunology
https://www.readbyqxmd.com/read/28315348/fc-gamma-receptor-3a-polymorphism-predicts-the-incidence-of-urinary-tract-infection-in-kidney-transplant-recipients
#18
Lalit Kumar Das, Kentaro Ide, Asuka Tanaka, Hiroshi Morimoto, Seiichi Shimizu, Naoki Tanimine, Yuka Tanaka, Hideki Ohdan
We investigated the impact of polymorphisms in host innate immunoregulatory genes on the development of infectious complications after kidney transplantation (KT). The single-nucleotide polymorphisms (SNPs) of C1QA [276 A/G], FCGR2A [131 H/R], and FCGR3A [158 F/V], genes encoding the Fc gamma receptor (FcγR), were analyzed in 81 KT recipients in relation to the occurrences of postoperative infectious complications within 30days after KT. Consistent with a lower affinity of the isoform encoded by the FCGR3A [158 F] to both IgG1 and IgG3, a significantly higher incidence of urinary tract infections (UTIs) was observed in the FCGR3A [158 F/V or F/F] individuals (65...
April 2017: Human Immunology
https://www.readbyqxmd.com/read/28284829/histopathologic-changes-in-anti-angiotensin-ii-type-1-receptor-antibody-positive-kidney-transplant-recipients-with-acute-rejection-and-no-donor-specific-hla-antibodies
#19
Mary Ann Lim, Matthew Palmer, Jennifer Trofe-Clark, Roy D Bloom, Annette Jackson, Mary Carmelle Philogene, Malek Kamoun
OBJECTIVE: To determine the association of antibodies against angiotensin II type 1 receptor (AT1R Ab) and histopathologic changes seen in patients with kidney allograft rejection and negative donor specific HLA antibodies (DSA). METHODS: Stored sera from 27 patients who had biopsy-proven rejection in the absence of DSA were tested for AT1R Ab. Biopsy slides of all patients were re-examined and classified according to Banff 2013 criteria. Histopathologic changes were compared between AT1R positive and negative patients...
April 2017: Human Immunology
https://www.readbyqxmd.com/read/28279756/analysis-of-ccr5-gene-polymorphisms-in-321-healthy-saudis-using-next-generation-sequencing
#20
Mohammed A Al Balwi, Ali I Hadadi, Wardah Alharbi, Mariam Ballow, Abdulrahman AlAsiri, Abdulkareem AlAbdulrahman, Udayaraja G K, Mohammed Aldrees, Ibrahim AlAbdulkareem, Ali H Hajeer
AIMS: To investigate the extent of CCR5 polymorphism in the healthy Saudi population. METHOD: A total of 321 healthy Saudi individuals were sequenced using the ion Ampliseq™ Exome kit (Life Technologies, USA) on genomic DNA following manufacturer's protocol. Whole Exome Sequencing (WES) reads were aligned to the human reference genome (hg19 build) with Torrent Suite Software (v5.0.2) and the variants were called using the Torrent Variant Caller plugin (v5.0) and imported into Ion Reporter Server (v5...
April 2017: Human Immunology
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