journal
MENU ▼
Read by QxMD icon Read
search

Human Immunology

journal
https://www.readbyqxmd.com/read/28535968/abnormal-distribution-of-distinct-lymphocyte-subsets-in-children-with-wiskott-aldrich-syndrome
#1
Lina Zhou, Wenyan Li, Xuan Zhang, Dawei Liu, Yuan Ding, Rongxin Dai, Xiaodong Zhao
Wiskott-Aldrich syndrome (WAS) is a severe and rare primary immunodeficiency. Several studies show that WAS protein (WASp) plays a key role in the function of certain lymphocyte subsets. So far, no study has described distinct immunophenotypic abnormalities associated with WAS; thus the prognostic significance of any such abnormalities is unclear. This study examined many differences in the percentage/absolute numbers of distinct lymphocyte subsets in 20 WAS patients and 20 age/sex-matched healthy controls, and analyzed the association between these abnormalities and clinical disease scores...
May 20, 2017: Human Immunology
https://www.readbyqxmd.com/read/28528709/association-between-the-killer-cell-immunoglobulin-like-receptor-a-haplotype-and-childhood-acute-lymphoblastic-leukemia
#2
Awad E Osman, Abdullah Aljuryan, Hanan Al-Harthi, Mai Almeshari
Killer immunoglobulin-like receptors (KIRs) have the ability to regulate Natural killer (NK) cell function through inhibition/activation mechanisms. Healthy human cells express HLA class I ligands on their surface, which are recognized by NK cells to avoid spontaneous cell destruction. The associations of KIRs and/or HLA class 1 ligands in leukemic patients have been studied in some populations, with some of these studies demonstrating an association of specific types with leukemia. KIRs and their corresponding HLA class 1 ligands were investigated in Saudi patients with ALL and AML and compared to healthy controls...
May 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28528708/depletion-of-the-chimeric-drug-rituximab-from-biological-samples
#3
Benita K Book, Mark D Pescovitz, Lili Guo, Eric A Wiebke
No abstract text is available yet for this article.
May 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28501500/it-s-about-time-the-development-and-validation-of-a-rapid-optimized-single-antigen-bead-rob-assay-protocol-for-labscreen
#4
Robert S Liwski, Anna L Greenshields, Cathi Murphey, Robert A Bray, Howard M Gebel
The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased donor workups or post-transplant assessments. Here we describe the development and validation of the Rapid Optimized SAB (ROB) protocol, a modified version of the One Lambda LABScreen SAB (OLSAB) procedure, which reduces assay time from 85 to 25min (>70% reduction) without impacting assay quality or sensitivity...
May 10, 2017: Human Immunology
https://www.readbyqxmd.com/read/28465172/human-leukocyte-antigen-class-i-a-b-and-c-allele-and-haplotype-variation-in-a-south-african-indian-population
#5
Shayne Loubser, Maria Paximadis, Caroline T Tiemessen
In 2013, ∼1,329,300 individuals made up the South African Indian population, which constituted ∼2.5% of the total population of ∼53 million. Historically, from 1860-1911, indentured labourers were imported from India, to work in the sugar-cane plantations in the KwaZulu-Natal Province. The local Indian community was further augmented by "passenger" immigrants who paid for passage to South Africa. Extensive HLA allelic variability exists in mainland Indian populations. We investigated HLA-A, -B and -C allele and haplotype diversity in 50 healthy, unrelated individuals recruited from the South African Indian population for comparison to data from mainland India...
April 29, 2017: Human Immunology
https://www.readbyqxmd.com/read/28442289/hla-a-b-and-c-allele-and-haplotype-frequencies-defined-by-next-generation-sequencing-in-a-population-of-519-english-blood-donors
#6
Sue Davey, John Ord, Cristina Navarrete, Colin Brown
Whole gene next generation sequencing was used to determine the HLA class I haplotype and allele frequencies in a cohort of 519 English blood donors. This is the first report of HLA frequencies at third field resolution in a UK population with a total of 33, 52 and 30 alleles identified for HLA-A, -B and -C, respectively. Of the 1411 haplotypes determined, 281 had a frequency of greater than 0.05%. Data are available from the Allele Frequencies Net Database under the population name 'England Blood Donors of Mixed Ethnicity', identifier 3392...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28442288/expression-and-differential-regulation-of-hla-g-isoforms-in-the-retinal-pigment-epithelial-cell-line-arpe-19
#7
Signe Goul Svendsen, Maja Søberg Udsen, Marina Daouya, Tina Funck, Ching-Lien Wu, Edgardo D Carosella, Joël LeMaoult, Thomas Vauvert F Hviid, Carsten Faber, Mogens Holst Nissen
The purpose of this study was to examine if HLA-G is expressed in the retinal pigment epithelium (RPE) cells of the eye. The RPE comprises the outer most layer of the retina and as such defines the interface to the blood and contributes to the immune privilege in the posterior part of the eye. One way the RPE might be regulating the immune system could be by expressing the non-classical human leukocyte antigen (HLA) molecule, HLA-G. We therefore sought to define if the RPE cell line, ARPE-19, expressed HLA-G and analyse the regulation as a response to pro-inflammatory cytokines...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28442287/hla-a-b-drb1-allele-and-haplotype-frequencies-of-674-cord-blood-donors-from-north-italy
#8
C Capittini, A De Silvestri, M Guarene, A Pasi, C Tinelli, C Perotti
No abstract text is available yet for this article.
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28438554/interleukin-17f-and-interleukin-6-gene-polymorphisms-in-asian-indian-patients-with-takayasu-arteritis
#9
Debashish Danda, Ruchika Goel, Sumita Danda, Hindhumathi Mohan, George Joseph, Jayakanthan Kabeerdoss, Swapan K Nath
OBJECTIVES: To assess genetic association between single nucleotide polymorphisms (SNPs) in genes encoding T-helper cytokines and Takayasu Arteritis (TA) susceptibility in Asian Indian population. METHODS: In Phase-1, the genomic DNA of 120 TA patients and 119 healthy controls were genotyped for SNPs rs1800795 (interleukin (IL)-6), rs763780 (IL-17F), rs1800871, rs1800872, rs1800896 (IL-10) and rs1800468, rs1800469, rs1800470 (transforming growth factor-β). Allele frequencies between cases and controls were compared using chi-squared test and also reassessed empirically (pe) by 10,000 permutations...
April 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28438553/human-leukocyte-antigen-class-i-a-b-and-c-allele-and-haplotype-variation-in-a-south-african-mixed-ancestry-population
#10
Shayne Loubser, Maria Paximadis, Caroline T Tiemessen
South Africa has a large (∼53million), ethnically diverse population (black African, Caucasian, Indian/Asian and Mixed ancestry) and a high disease burden (particularly HIV-1 and Mycobacterium tuberculosis). The Mixed ancestry population constitutes ∼9% of the total population and was established ∼365years ago in the Western Cape region through interracial mixing of black Africans, Europeans and Asians. Admixed populations present unique opportunities to identify genetic factors involved in disease susceptibility...
April 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431960/nomenclature-for-factors-of-the-hla-system-update-march-2017
#11
Steven G E Marsh
No abstract text is available yet for this article.
April 19, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431959/nomenclature-for-factors-of-the-hla-system-update-february-2017
#12
Steven G E Marsh
No abstract text is available yet for this article.
April 19, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431958/nomenclature-for-factors-of-the-hla-system-update-january-2017
#13
Steven G E Marsh
No abstract text is available yet for this article.
April 19, 2017: Human Immunology
https://www.readbyqxmd.com/read/28431957/genetic-study-of-kir-and-hla-ligands-in-235-individuals-from-northeastern-thailand
#14
Suwit Chaisri, Chanvit Leelayuwat, Amornrat Romphruk
The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP) method. The Hardy-Weinberg Equilibrium (HWE) was used to verify genotyping method for dimorphic KIR and HLA. They were in HWE (p>0.05). KIR and HLA ligands frequencies, genotypes, haplotypes and linkage disequilibrium (LD) were presented. The genetic data are available in allele Frequencies Net Database...
April 18, 2017: Human Immunology
https://www.readbyqxmd.com/read/28372986/assessing-the-potential-of-angiotensin-ii-type-1-receptor-and-donor-specific-anti-endothelial-cell-antibodies-to-predict-long-term-kidney-graft-outcome
#15
David F Pinelli, John J Friedewald, Kelley M K Haarberg, Shree L Radhakrishnan, Jennifer R Zitzner, Wendy E Hanshew, Anat R Tambur
Endothelial cell antigens have been reported as potential targets for antibodies in the context of organ transplantation, leading to increased risk for graft failure. Serum samples from 142 consecutive living donor kidney recipients were tested for the presence of antibodies to angiotensin II - type 1 receptor (AT1R), donor endothelial cells, and donor HLA. Graft survival was monitored for five years post-transplant, and secondary outcomes, including biopsy-proven rejection, proteinuria, biopsy-proven vasculopathy, and renal function based on serum creatinine were also assessed for the first two to three years...
March 31, 2017: Human Immunology
https://www.readbyqxmd.com/read/28359736/hla-a-b-drb1-dqa1-dqb1-alleles-and-haplotype-frequencies-in-dene-and-cree-cohorts-in-manitoba-canada
#16
Linda A Larcombe, Leigh Anne Shafer, Peter W Nickerson, Andrew M Lodge, Jodie S Brown, Leisel C Milligan, Denise Pochinco, Lynnette Beaudin, Brian Arundel, Jacqueline Wong, Joe Dantouze, Lizette Denechezhe, Pamela H Orr
BACKGROUND: First Nations in the Canadian province of Manitoba have disproportionately high rates of epidemic and endemic TB. Gene polymorphisms that modulate HLA Class I and II antigens are among the risk markers for TB, along with other biologic, and social determinants of health. HLA-A, B, DRB1, DQA1, DQB1 were typed in two Manitoba First Nation indigenous groups to identify and compare the frequency of gene polymorphisms that may influence susceptibility or resistance to TB. METHODS: Participants who self-identified as either Dene or Cree enrolled into the study from two First Nation communities in Manitoba, Canada...
March 27, 2017: Human Immunology
https://www.readbyqxmd.com/read/28347702/cytokine-gene-polymorphisms-in-populations-from-parana-southern-brazil
#17
Pâmela Guimarães Reis, Josiane Bazzo de Alencar, Luciana Conci Macedo, Eliane Papa Ambrosio-Albuquerque, Julimary Suematsu de Aquino, Joana Maira Valentini Zacarias, Patrícia Yumeko Tsuneto, Ricardo Alberto Moliterno, Ana Maria Sell, Jeane Eliete Laguila Visentainer
In this study, were genotyped 22 single nucleotide polymorphisms (SNPs) in 13 genes that encode the pro-inflammatory (IL-1α, IL-1β, IL-1R, IL-4Rα, IL-12, IFN-γ, TNF-α, and IL-2) and anti-inflammatory (IL-1RA, TGF-β, IL-4, IL-6 and IL-10) cytokines of 350 individuals by PCR-SSP (polymerase chain reaction - sequence specific primer). A total of 473 individuals were genotyped for IL17A and IL17F genes by PCR-RFLP (restriction fragment length polymorphism). The sample consisted of healthy and unrelated subjects from a mixed population from Parana state, in the South region of Brazil...
March 25, 2017: Human Immunology
https://www.readbyqxmd.com/read/28341250/modulation-of-lilrb2-protein-and-mrna-expressions-in-septic-shock-patients-and-after-ex-vivo-lipopolysaccharide-stimulation
#18
Fabienne Venet, Jeremy Schilling, Marie-Angélique Cazalis, Julie Demaret, Fanny Poujol, Thibaut Girardot, Christelle Rouget, Alexandre Pachot, Alain Lepape, Arnaud Friggeri, Thomas Rimmelé, Guillaume Monneret, Julien Textoris
Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study, we identified LILRB2 as an upregulated gene in septic shock patients. On monocytes primed with LPS ex vivo, LILRB2 mRNA and protein expressions were dose-dependently downregulated and subsequently highly upregulated versus non-stimulated cells...
March 22, 2017: Human Immunology
https://www.readbyqxmd.com/read/28336310/regulatory-role-of-ccl5-rs2280789-and-cxcl10-rs56061981-gene-polymorphisms-on-intracellular-ccl5-and-cxcl10-expression-in-pulmonary-tuberculosis
#19
Brijendra Singh, Selvaraj Anbalagan, Paramasivam Selvaraj
Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellular CCL5 and CXCL10 expression in T cells. Whole blood cell cultures were stimulated with culture filtrate antigen (CFA) and infected with live M. tuberculosis were used for intracellular CCL5 and CXCL10 expression using flow cytometry...
March 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28336309/usefulness-of-the-ellipro-epitope-predictor-program-in-defining-the-repertoire-of-hla-abc-eplets
#20
Rene J Duquesnoy, Marilyn Marrari
HLA matching at the epitope level offers new opportunities to identify suitable donors for transplant patients. The International HLA Epitope Registry (www.Epregistry.com.br) describes for the various HLA loci, repertoires of eplets including those that correspond to epitopes experimentally verified with specific antibodies. There are also many eplets which have remained as theoretical entities because no informative antibodies have been found. Which of them have immunogenic potential or conversely, might be considered as non-epitopes that cannot elicit specific antibody responses? This question is important for the application of epitope-based HLA matching in clinical transplantation...
March 21, 2017: Human Immunology
journal
journal
28052
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"