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Peptides

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https://www.readbyqxmd.com/read/28192152/potential-role-for-growth-hormone-releasing-hormone-in-triple-negative-breast-cancer
#1
LETTER
Alice Lee
No abstract text is available yet for this article.
February 9, 2017: Peptides
https://www.readbyqxmd.com/read/28192151/angiotensin-1-7-dependent-vasorelaxation-of-the-renal-artery-exhibits-unique-angiotensin-and-bradykinin-receptor-selectivity
#2
Mariam H M Yousif, Ibrahim F Benter, Debra I Diz, Mark C Chappell
Angiotensin-(1-7) [Ang-(1-7)] exhibits blood pressure lowering actions, inhibits cell growth, and reduces tissue inflammation and fibrosis which may functionally antagonize an activated Ang II-AT1 receptor axis. Since the vascular actions of Ang-(1-7) and the associated receptor/signaling pathways varies in different vascular beds, the current study established the vasorelaxant properties of the heptapeptide in the renal artery of male Wistar male rats. Ang-(1-7) produced an endothelium-dependent vasodilator relaxation of isolated renal artery segments pre-contracted by a sub-maximal concentration of phenylephrine (PE) (10(-7)M)...
February 9, 2017: Peptides
https://www.readbyqxmd.com/read/28189525/ghrelin-inhibits-atherosclerotic-plaque-angiogenesis-and-promotes-plaque-stability-in-a-rabbit-atherosclerotic-model
#3
Li Wang, Qingwei Chen, Dazhi Ke, Guiqiong Li
Intraplaque angiogenesis associates with the instability of atherosclerotic plaques. In the present study, we investigated the effects of ghrelin on intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis. The rabbits were randomly divided into three groups, namely, the control group, atherosclerotic model group, and ghrelin-treated group, with treatments lasting for 4 weeks. We found that the thickness ratio of the intima to media in rabbits of the ghrelin-treated group was significantly lower than that in rabbits of the atherosclerotic model group...
February 9, 2017: Peptides
https://www.readbyqxmd.com/read/28185816/the-predictive-value-of-plasma-catestatin-for-all-cause-and-cardiac-deaths-in-chronic-heart-failure-patients-methodological-issues
#4
LETTER
Ahad Ashrafi-Asgarabad, Abbas Behroozi, Saeid Safiri
No abstract text is available yet for this article.
February 6, 2017: Peptides
https://www.readbyqxmd.com/read/28174072/molecular-characterization-and-functional-analyses-of-a-diapause-hormone-receptor-like-gene-in-parthenogenetic-artemia
#5
Hui-Li Ye, Dong-Rui Li, Jin-Shu Yang, Dian-Fu Chen, Stephanie De Vos, Marnik Vuylsteke, Patrick Sorgeloos, Gilbert Van Stappen, Peter Bossier, Hiromichi Nagasawa, Wei-Jun Yang
In arthropods, mature females under certain conditions produce and release encysted gastrula embryos that enter diapause, a state of obligate dormancy. The process is presumably regulated by diapause hormone (DH) and diapause hormone receptor (DHR) that were identified in the silkworm, Bombyx mori and other insects. However, the molecular structure and function of DHR in crustaceans remains unknown. Here, a DHR-like gene from parthenogenetic Artemia (Ar-DHR) was isolated and sequenced. The cDNA sequence consists of 1410bp with a 1260-bp open reading frame encoding a protein consisting of 420 amino acid residues...
February 4, 2017: Peptides
https://www.readbyqxmd.com/read/28161427/purification-and-function-of-two-analgesic-and-anti-inflammatory-peptides-from-coelomic-fluid-of-the-earthworm-eisenia-foetida
#6
Chunlong Li, Mengrou Chen, Xiaojie Li, Meifeng Yang, Ying Wang, Xinwang Yang
The potential application of anti-inflammatory and analgesic compounds in medication and therapeutic care have become of increasing interest. We purified and characterized two novel analgesic and anti-inflammatory peptides, VQ-5 and AQ-5, from the coelomic fluid of the earthworm (Eisenia foetida). Their primary structures were determined as VSSVQ and AMADQ, respectively. Both peptides, especially AQ-5, exhibited analgesic activity in mouse models of persistent neuropathic pain and inflammation. AQ-5 also inhibited tumor necrosis factor alpha and cyclooxygenase-2 production...
February 2, 2017: Peptides
https://www.readbyqxmd.com/read/28153500/endothelin-causes-transactivation-of-the-egfr-and-her2-in-non-small-cell-lung-cancer-cells
#7
Terry W Moody, Irene Ramos-Alvarez, Paola Moreno Perez, Samuel A Mantey, Lisa Ridnour, David Wink, Robert T Jensen
Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ETA receptor (R) and ETBR on cancer cells. High levels of tumor ET-1 and ETAR are associated with poor survival of lung cancer patients. Here the effects of ET-1 on epidermal growth factor (EGF)R and HER2 transactivation were investigated using non-small cell lung cancer (NSCLC) cells. ETAR mRNA was present in all 10 NSCLC cell lines examined...
January 30, 2017: Peptides
https://www.readbyqxmd.com/read/28143736/hybrid-peptides-in-the-landscape-of-drug-discovery
#8
EDITORIAL
Daniel Fourmy
No abstract text is available yet for this article.
January 28, 2017: Peptides
https://www.readbyqxmd.com/read/28130121/synthesis-and-structure-activity-studies-on-novel-analogs-of-human-growth-hormone-releasing-hormone-ghrh-with-enhanced-inhibitory-activities-on-tumor-growth
#9
Marta Zarandi, Renzhi Cai, Magdolna Kovacs, Petra Popovics, Luca Szalontay, Tengjiao Cui, Wei Sha, Miklos Jaszberenyi, Jozsef Varga, XianYang Zhang, Norman L Block, Ferenc G Rick, Gabor Halmos, Andrew V Schally
The syntheses and biological evaluations of new GHRH analogs of Miami (MIA) series with greatly increased anticancer activity are described. In the design and synthesis of these analogs, the following previous substitutions were conserved: D-Arg(2), Har(9), Abu(15), and Nle(27). Most new analogs had Ala at position 8. Since replacements of both Lys(12) and Lys(21) with Orn increased resistance against enzymatic degradation, these modifications were kept. The substitutions of Arg at both positions 11 and 20 by His were also conserved...
January 24, 2017: Peptides
https://www.readbyqxmd.com/read/28130120/trifluoroacetylated-tyrosine-rich-d-tetrapeptides-have-potent-antioxidant-activity
#10
Annamaria Sandomenico, Valeria Severino, Fabio Apone, Adriana De Lucia, Andrea Caporale, Nunzianna Doti, Anna Russo, Rosita Russo, Camilla Rega, Tiziana Del Giacco, Lucia Falcigno, Menotti Ruvo, Angela Chambery
The term "oxidative stress" indicates a set of chemical reactions unleashed by a disparate number of events inducing DNA damage, lipid peroxidation, protein modification and other effects, which are responsible of altering the physiological status of cells or tissues. Excessive Reactive Oxygen Species (ROS) levels may accelerate ageing of tissues or induce damage of biomolecules thus promoting cell death or proliferation in dependence of cell status and of targeted molecules. In this context, new antioxidants preventing such effects may have a relevant role as modulators of cell homeostasis and as therapeutic agents...
January 24, 2017: Peptides
https://www.readbyqxmd.com/read/28119091/functional-interaction-between-bdnf-and-mglur-ii-in-vitro-bdnf-down-regulated-mglur-ii-gene-expression-and-an-mglur-ii-agonist-enhanced-bdnf-induced-bdnf-gene-expression-in-rat-cerebral-cortical-neurons
#11
Shingo Suzuki, Hisatsugu Koshimizu, Naoki Adachi, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-Ichi Ohta, Takanori Miki
Accumulating evidence suggests functional interaction between brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor (mGluR) signaling pathways in the central nervous system (CNS). To date, eight subtypes of mGluRs, mGluR1-8, have been identified, and a previous study suggested that BDNF leads to down-regulation of GluR2 mRNA in rat cerebral cortical cultures. However, precise transcriptomic effects of BDNF on other mGluRs and their cellular significance on the BDNF signaling pathway remain largely unknown...
January 21, 2017: Peptides
https://www.readbyqxmd.com/read/28108197/identification-of-aminopeptidase-n2-as-a-cry2ab-binding-protein-in-manduca-sexta
#12
Janette Onofre, Meztlli O Gaytán, Arlen Peña-Cardeña, Blanca I García-Gomez, Sabino Pacheco, Isabel Gómez, Alejandra Bravo, Mario Soberón
Bacillus thuringiensis Cry2Ab toxin has been used in combination with Cry1Ac for resistance management on the Bt-cotton that is widely planted worldwide. However, little is known regarding Cry2Ab mode of action. Particularly, there is a gap of knowledge on the identification of insect midgut proteins that bind Cry2Ab and mediate toxicity. In the case of Cry1Ab toxin, a transmembrane cadherin protein and glycosyl-phosphatidylinositol (GPI) anchored proteins like aminopeptidase-N1 (APN1) or alkaline-phosphatase (ALP) from Manduca sexta, have been shown to be important for oligomer formation and insertion into the membrane...
January 17, 2017: Peptides
https://www.readbyqxmd.com/read/28088445/synthesis-and-exploration-of-novel-radiolabeled-bombesin-peptides-for-targeting-receptor-positive-tumor
#13
Kakali De, Indranil Banerjee, Samarendu Sinha, Shantanu Ganguly
Increasing evidence of peptide receptor overexpression in various cancer cells, warrant the development of receptor specific radiolabeled peptides for molecular imaging and therapy in nuclear medicine. Gastrin-releasing-peptide (GRP) receptor, are overexpressed in a variety of human cancer cells. The present study report the synthesis and biological evaluation of new bombesin (BBN) analogs, HYNIC-Asp-[Phe(13)]BBN(7-13)-NH-CH2-CH2-CH3:BA1, HYNIC-Pro-[Tyr(13)Met(14)]BBN(7-14)NH2:BA2 as prospective tumor imaging agent with compare to BBN(7-14)NH2:BS as standard...
January 11, 2017: Peptides
https://www.readbyqxmd.com/read/28088444/feeding-recombinant-e-coli-with-gst-mbmktx-fusion-protein-increases-the-fecundity-and-lifespan-of-caenorhabditis-elegans
#14
Jie Xu, Yajie Jiang, Lu Wan, Qi Wang, Zebo Huang, Yongmei Liu, Yingliang Wu, Zongyun Chen, Xin Liu
Scorpion venom could be a useful treatment for a variety of diseases, such as cancer, epilepsy and analgesia. BmKTX is a polypeptide extracts from scorpion venom (PESV), which have attracted much attention from researchers in recent years. mBmKTX is a mutant polypeptide according to the amino acid sequence of BmKTX. We expressed it with the vector pGEX-4T-1 in Escherichia coli, and Caenorhabditis elegans were used as the animal model and fed with the strains. In this study, the expression of pGEX-mBmKTX was analyzed by SDS-PAGE, and GST-mBmKTX purified from pGEX-mBmKTX as a glutathione S-transferase (GST)-tagged fusion protein is approximately 30kDa...
January 11, 2017: Peptides
https://www.readbyqxmd.com/read/28087413/nesfatin-1-modulates-murine-gastric-vagal-afferent-mechanosensitivity-in-a-nutritional-state-dependent-manner
#15
Stephen J Kentish, Hui Li, Claudine L Frisby, Amanda J Page
Food intake is regulated by vagal afferent signals from the stomach. Nesfatin-1 is an anorexigenic peptide produced within the gastrointestinal tract and has well defined central effects. We aimed to determine if nesfatin-1 can modulate gastric vagal afferent signals in the periphery and further whether this is altered in different nutritional states. Female C57BL/6J mice were fed either a standard laboratory diet (SLD) or a high fat diet (HFD) for 12 weeks or fasted overnight. Plasma nucleobindin-2 (NUCB2; nesfatin-1 precursor)/nesfatin-1 levels were assayed, the expression of NUCB2 in the gastric mucosa and adipose tissue was assessed using real-time quantitative reverse-transcription polymerase chain reaction...
January 10, 2017: Peptides
https://www.readbyqxmd.com/read/28082215/neuropeptides-encoded-within-a-neural-transcriptome-of-the-giant-triton-snail-charonia-tritonis-a-crown-of-thorns-starfish-predator
#16
U Bose, S Suwansa-Ard, L Maikaeo, C A Motti, M R Hall, S F Cummins
Neuropeptides represent a diverse class of signaling molecules originating from neural tissues. These chemical modulators orchestrate complex physiological events including those associated with growth and reproduction. De novo transcriptome sequencing of a cerebral ganglion library of the endangered giant triton snail (Charonia tritonis) was undertaken in an effort to identify key neuropeptides that control or influence its physiology. The giant triton snail is considered a primary predator of the corallivore Acanthaster planci (Crown-of-Thorns Starfish) that is responsible for a significant loss in coral cover on reefs in the Indo-Pacific...
January 9, 2017: Peptides
https://www.readbyqxmd.com/read/28049031/the-efficacy-of-dynorphin-fragments-at-the-%C3%AE%C2%BA-%C3%AE-and-%C3%AE-opioid-receptor-in-transfected-hek-cells-and-in-an-animal-model-of-unilateral-peripheral-inflammation
#17
M Morgan, A Heffernan, F Benhabib, S Wagner, A K Hewavitharana, P N Shaw, P J Cabot
Dynorphin 1-17 is an endogenous peptide that is released at sites of inflammation by leukocytes, binding preferentially to κ-opioid receptors (KOP) to mediate nociception. We have previously shown that dynorphin 1-17 is rapidly biotransformed to smaller peptide fragments in inflamed tissue homogenate. This study aimed to determine the efficacy and potency of selected dynorphin fragments produced in an inflamed environment at the KOP, μ and δ-opioid receptors (MOP and DOP respectively) and in a model of inflammatory pain...
December 31, 2016: Peptides
https://www.readbyqxmd.com/read/28041976/moving-pieces-in-a-cryptomic-puzzle-cryptide-from-tityus-serrulatus-ts3-nav-toxin-as-potential-agonist-of-muscarinic-receptors
#18
Cibele Rocha-Resende, Nádia Miricéia Leão, Maria Elena de Lima, Robson Augusto Santos, Adriano Monteiro de Castro Pimenta, Thiago Verano-Braga
Cryptome is as a subset of a given proteome containing bioactive cryptides embedded in larger peptides or proteins. We pinpointed a striking sequence similarity between two peptides from the Tityus serrulatus venom: Ts10 (KKDGYPVEYDRAY) and the N-terminal of Ts3 (KKDGYPVEYDNCAY). Ts3 (former Tityustoxin or TsIV) is an α-neurotoxin acting on voltage-gated sodium channels while Ts10 (former Peptide T) is a bradykinin-potentiating peptide and was originally reported as inhibitor of the angiotensin-converting enzyme (ACEi)...
December 29, 2016: Peptides
https://www.readbyqxmd.com/read/28024903/cloning-localization-and-physiological-effects-of-sulfakinin-in-the-kissing-bug-rhodnius-prolixus
#19
Hussain Al-Alkawi, Angela B Lange, Ian Orchard
Sulfakinins (SKs) are a family of multifunctional neuropeptides that have been shown to have myotropic activity on muscles of the digestive system and to function as feeding satiety factors. Here, we confirm via cloning the presence of two sulfakinins (Rhopr-SK-1 and Rhopr-SK-2) in Rhodnius prolixus. Reverse transcriptase quantitative PCR demonstrates that the Rhopr-SK transcript is highly expressed in the central nervous system (CNS) of unfed fifth-instar R. prolixus. Fluorescent in situ hybridization shows transcript expression only in neurons in the brain...
December 23, 2016: Peptides
https://www.readbyqxmd.com/read/28062253/spinal-neuropeptide-expression-and-neuropathic-behavior-in-the-acute-and-chronic-phases-after-spinal-cord-injury-effects-of-progesterone-administration
#20
María F Coronel, Marcelo J Villar, Pablo R Brumovsky, Susana L González
Patients with spinal cord injury (SCI) develop chronic pain that severely compromises their quality of life. We have previously reported that progesterone (PG), a neuroprotective steroid, could offer a promising therapeutic strategy for neuropathic pain. In the present study, we explored temporal changes in the expression of the neuropeptides galanin and tyrosine (NPY) and their receptors (GalR1 and GalR2; Y1R and Y2R, respectively) in the injured spinal cord and evaluated the impact of PG administration on both neuropeptide systems and neuropathic behavior...
February 2017: Peptides
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