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Neuro Endocrinology Letters

Kun Han, Chunni Liu, Xiujuan Shi, Xiaopang Rao
OBJECTIVE: To observe the clinical curative effects of alprostadil combined with calcium dobesilate in type 2 diabetes patients with peripheral neuropathy. METHODS: We randomly divided 120 type 2 diabetes patients with diabetic peripheral neuropathy into two groups. The treatment group was prescribed alprostadil (10 μg, once daily) and oral calcium dobesilate (0.5 g, 3 times daily), and the control group was prescribed alprostadil (10 μg, once daily) for a total treatment duration of 2 weeks...
May 6, 2018: Neuro Endocrinology Letters
Ling He, Mingjun Xie, Hong Zhang, Linfeng Meng, Xiaoping Zhang
BACKGROUND: Patients with irritable bowel syndrome (IBS) frequently present with alterations of autonomic activity, especially higher sympathetic activity. Salivary alpha-amylase (sAA) has been implicated as a non-invasive biomarker to reflect the sympathetic activity. Thus, the current study aimed to determine if alterations of sAA secretion could be addressed in IBS patients. METHODS: We recruited twenty-five IBS patients as well as twenty-four age- and sex-matched healthy controls (HCs)...
May 6, 2018: Neuro Endocrinology Letters
Song Qiao, Qi Xu, Lin Cheng, Ying Zhang, Xiaoli Liu, Chaobo Zheng, Xiaofeng Hu, Linhui Chen
BACKGROUND: Medial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy. In recent years, the important roles of lncRNAs in regulating human diseases progression had been implicated, including in epilepsy. However, comprehensive analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy was still lacking. OBJECTIVES: The aim of this study was to explore relevant lncRNAs in MTLE. METHODS: In present study, we analyzed a public dataset GSE25453 to identify differentially expressed lncRNAs and mRNAs in the MTLE...
May 6, 2018: Neuro Endocrinology Letters
Farshid Sargazi, Mohammad Shokrzadeh, Saeid Abediankenari, Seyed Vahid Hoseini, Nafiseh Nasri Nasrabadi, Mojtaba Najafi, Hamed Haghi-Aminjan, Seyedeh Habibeh Mirmajidi, Ramin Ataee
Gastric cancer accounts 8% of the total cancer cases leading to 10% of total cancer deaths worldwide. The indoleamine N-acetyl-5-methoxytryptamine, better known as melatonin, is the principal hormone produced by the pineal gland. Recently, it has been well documented some anti-cancer roles of melatonin in some malignancies as breast and colon cancer; as well as some its protective roles in the GI tract that have been known as free radical scavenger, antimitogenic and apoptotic properties. According to the anti-cancer effects of melatonin, wide distribution of this neurohormone in GI tract and some proposed physiologic and pharmacologic roles for this neurohormone and following our previous study which has shown expression of MT2 receptor in gastric adenocarcinoma, this study initially scheduled to determine the expression of melatonin receptor MT1 in tissue samples of adenocarcinoma cancer patients...
May 6, 2018: Neuro Endocrinology Letters
Yan Yang, Zheng-Rong Qi, Ting-Ting Zhang, Yao-Jie Kang, Xuan Wang
BACKGROUND: A few reports had revealed the clinical associations between hypopituitarism and non-alcoholic fatty liver disease (NAFLD). Further evidences were needed. OBJECTIVES: To report 5 cases of young patients with rapidly progressive NAFLD in conjunction with hypopituitarism, aiming to detect the associations. METHODS: Clinical data of the 5 patients were analyzed retrospectively. All had decompensated liver cirrhosis that was finally attributed to NAFLD...
May 6, 2018: Neuro Endocrinology Letters
Katarina Klobucnikova, Pavel Siarnik, Ivana Muchova, Juraj Štofko, Branislav Kollar
The aim of this study is to remind the possibility of co-occurrence of epilepsy and narcolepsy. In the first case report, narcolepsy type 1 was diagnosed in 29-year-old female. After one year of the treatment with modafinil a new episodes of automatic behavior appeared. Patient was reevaluated and the diagnosis of focal epilepsy with partial complex seizures was established. Patient was treated with modafinil and lamotrigine and became seizure-free. In the second case report a 21-year-old female was referred with a typical history of narcolepsy type 1, but also with atypical episodes of gazing and automatic behavior with amnesia for these episodes...
May 6, 2018: Neuro Endocrinology Letters
Long Ma, Lu Wang, Xiaoxuan Fang, Cong-Hai Zhao, Libo Sun
To investigate the diagnosis, treatment and prognosis of solitary fibrous tumor (SFT)/ hemangiopericytoma (HPC) of central nervous system (CNS), we retrospectively reviewed records of 17 patients who were treated for CNS SFT/HPC at the Department of Neurosurgery, China-Japan Union Hospital of Jilin University from December 2010 to June 2016, and reevaluated their pathological diagnoses according to the 2016 WHO classification of CNS tumors. We then analyzed their clinical symptoms, imaging characteristics, treatments and outcomes...
May 6, 2018: Neuro Endocrinology Letters
Hui Zhu, Yan-Bo Hou, Ji-Guo Gao, Teng Zhao, Chun-Kui Zhou, Jing-Yao Liu
We report a case of a 51-year-old man with limbic encephalitis (LE) associated with antibodies against the α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid receptor (AMPAR). The patient presented with anterograde memory loss for 2 months. Cranial magnetic resonance and electroencephalogram were normal. AMPAR antibodies were found in blood serum and cerebrospinal fluid. All other test results were unremarkable. CT scans found a tumor in the right lobus superior pulmonis. A CT-guided needle biopsy was performed and pathological results showed small cell lung cancer (SCLC)...
May 6, 2018: Neuro Endocrinology Letters
Radek Trnka, Jozef Hasto, Inna Cabelkova, Martin Kuska, Peter Tavel, Tomas Nikolai
Parkinson's disease (PD) is often accompanied by significant changes in emotionality, such as apathy, anhedonia, anxiety and depression. The present review summarizes the empirical evidence, including amygdala changes and psychological changes in emotionality in people suffering from PD. Seventeen empirical full-text articles including research on both amygdala and emotionality in PD were reviewed. The changes in amygdala volumes as well as changes in binding potentials, functional connectivity, regional homogeneity and regional cerebral blood flow were found to have various impacts on emotionality in people with PD...
May 6, 2018: Neuro Endocrinology Letters
Małgorzata Wójcik, Anna Ruszała, Ewa Szczudlik, Dominika Janus, Krystyna Sztefko
BACKGROUND: The clinical value of the diagnosis of metabolic syndrome (MS) in children and adolescents remains unclear. The aim of the present study was to assess the occurrence of metabolic complications, other than included in 2007 IDF MS definition, in obese children and adolescents METHODS: The study included 75 (33 boys) obese adolescents (mean age 13.9 years, mean BMI SDS 4.49). Classical (fasting glucose, TGL, HDL, blood pressure) and non classical (insulin resistance [HOMA-IR], creatinine, AST, ALT, uric acid, fibrinogen, liver US and 24h BP profile) risk factors were compared between groups with and without MS...
May 6, 2018: Neuro Endocrinology Letters
Milos Slepecky, Vladimir Stanislav, Maria Martinove, Antonia Kotianova, Michal Kotian, Michaela Chupacova, Jolanta Ryniak, Barbara Betkovka Korpala, Marta Zatkova, Klara Latalova, Jan Prasko
BACKGROUND: Poland, Czech Republic, and the Slovak Republic are countries with high alcohol consumption, and alcohol-induced disorders are in the ten leading causes of Years Lost due to Disability. Therefore it is necessary to study factors as insight, motivation, and readiness to change for the better understanding the variables which are in probably connected with therapeutic effectiveness. AIM: The purpose of the study was to examine the state of readiness to change at the beginning and the end of inpatient short (six weeks) and long (12 weeks) therapeutic program in the Slovak Republic, Poland, and the Czech Republic, and look for the relationship between readiness to change, insight, and motivation in alcohol-dependent persons...
May 2018: Neuro Endocrinology Letters
Watchara Sroykham, Yodchanan Wongsawat
OBJECTIVES: Testosterone and cortisol are the end products of the hypothalamus-pituitary-gonadal and hypothalamus-pituitary-adrenal axes. Both hormones affect brain anatomy and brain activity, which is positively correlated with the testosterone/cortisol ratio. The aim of the present study was to observe the main effect and interaction between testosterone and cortisol in relation to brain activity and whether it is possible to predict neuroendocrine levels. METHODS: Sixty-seven participants were included for evaluating saliva hormones and resting state EEG...
March 2018: Neuro Endocrinology Letters
Danielle Golub, Victor Rodack
OBJECTIVES: Hyperthyroidism has been associated with relatively rare presentations of psychotic symptoms. We report an example of the successful use of antipsychotics to manage psychotic symptoms in hyperthyroid-related psychosis. Furthermore, we systematically describe the available literature on the use of antipsychotics in this setting to determine the associated relative efficacies of the various antipsychotic agents. METHODS: Presentation of a case of hyperthyroid-related psychosis treated with an antipsychotic agent followed by a systematic review of all similar cases: PubMed, Ovid MEDLINE and PMC were searched for articles published between 1960 and 2017 that report on the use of specific antipsychotics in the management of hyperthyroid-related psychosis...
March 2018: Neuro Endocrinology Letters
Aneta Czerwonogrodzka-Senczyna, Małgorzata Jerzak, Anna Jeznach-Steinhagen, Katarzyna Karzel, Iwona Boniecka
OBJECTIVES: Assessment of the effects of consumption of fatty acids on the homocysteine levels in women with fertility disorders. METHODS AND RESULTS: The study included 286 women at the age between 23 and 46 years (the mean 33.13±4.21 years) with a fertility disorders. We measured: levels of homocysteine [μmol/L] (n=171), body weight and height (n=286). Body mass index (BMI) was calculated. A diet was assessed by 3-day dietary food records method including one day of the weekend...
March 2018: Neuro Endocrinology Letters
Joanna Boresowicz, Paulina Kober, Nataliia Rusetska, Maria Maksymowicz, Krzysztof Goryca, Jacek Kunicki, Wiesław Bonicki, Mateusz Bujko
OBJECTIVES: Pituitary adenomas (PAs) are among the most frequent intracranial tumors in humans. Abnormal telomerase activity and telomere lengthening are features of tumor cells. They may result from mutations in TERT promoter region, gene amplification or aberrant DNA methylation pattern. Such changes were found in variety of tumors including those of brain. Aim of the study was to evaluate the incidence of TERT abnormalities and to assess their role in telomere lengthening in PAs. METHODS: Study involved 101 patients with PA including both nonfunctioning and functioning subtypes...
March 2018: Neuro Endocrinology Letters
Tingting Tao, Ziyi Zhang, Hong Li
Lymphocytic hypophysitis (LH) is a rare inflammatory disorder involving the pituitary gland, often with other autoimmune diseases combined. The coexistence of LH and Behçet\'s disease (BD) is a rare combination and only one case was reported in the previous literatures. A 50-year-old man was admitted into Sir Run Run Shaw Hospital presented with frontal headache and fatigue which had lasted for four months. Endocrinological inspection indicated anterior pituitary dysfunction. Magnetic resonance imaging (MRI) revealed homogeneous pituitary enlargement and thickened pituitary stalk...
March 2018: Neuro Endocrinology Letters
Kristina Melkersson, Sophie Bensing
OBJECTIVES: Evidence has accumulated that an inflammatory, possibly autoimmune-mediated, process in the central nervous system (CNS), and by way of an aberrant immune system, may underlie the development of schizophrenia. Therefore, the aim of this study was to evaluate patients with schizophrenia or related psychosis for blood-brain barrier (BBB) function and immunoglobulin (Ig)G synthesis within the CNS. METHODS: Fifteen patients with schizophrenia or schizoaffective disorder and 12 controls were investigated using lumbar puncture and blood sampling...
March 2018: Neuro Endocrinology Letters
Michal Wilk, Petr Stastny, Artur Golas, Monika Nawrocka, Karel Jelen, Adam Zajac, James J Tufano
OBJECTIVES: Increasing muscular hypertrophy is one of the main reasons for participating in a resistance training program, where different movement task such as eccentric cadences may serve as a potent hypertrophic stimulus and improve movement stability. Aim of this study was to investigate the physiological responses between slow 6/0/2/0 (SLOW) and moderate 2/0/2/0 (REG) eccentric cadences during five sets of bench press to failure using 70% 1 repetition maximum (1RM). MATERIALS AND METHODS: Blood samples from sixteen men (21-29y, 85...
March 2018: Neuro Endocrinology Letters
Friedrich-Anton Weiser, Michael Fangl, Wilhelm Mosgoeller
OBJECTIVE: Papaya and oats are natural food and used in traditional medicine in many parts of the world. Papaya has a high content of enzymes supporting digestive function. Oats are a source of minerals, beta-glucan fibres, immunmodulatory and antiinflammatory probiotic substances. Caricol®-Gastro combines both constituents, it was designed as vegan organic preparation for intestinal inflammatory diseases. We performed a randomized, double blind placebo controlled clinical trial to investigate the potential of Caricol®-Gastro as add on therapy in patients with diagnosed chronic gastritis...
March 2018: Neuro Endocrinology Letters
Kristyna Vrbova, Jan Prasko, Michaela Holubova, Milos Slepecky, Marie Ociskova
OBJECTIVE: The purpose of the investigation was to explore the relationship between positive or negative symptoms, social anxiety, hope, personality, and self-stigma in patients with schizophrenia spectrum disorders. METHOD: 57 outpatients took part in this cross-sectional study. The structured interview M.I.N.I. International Neuropsychiatric Interview was used to confirm the diagnosis. All patients completed the Liebowitz Social Anxiety Scale, Internalized Stigma of Mental Illness Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Adult Dispositional Hope Scale, and Temperament and Character Inventory - Revised...
March 2018: Neuro Endocrinology Letters
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