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Carcinogenesis

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https://www.readbyqxmd.com/read/27881463/sestrin-3-modulation-is-essential-for-therapeutic-efficacy-of-cucurbitacin-b-in-lung-cancer-cells
#1
Naghma Khan, Farah Jajeh, Mohammad Imran Khan, Eiman Mukhtar, Sameh M Shabana, Hasan Mukhtar
Many purified compounds from dietary sources have been investigated for their anticancer activities. The main issue with most agents is their effectiveness at high doses which generally could not be delivered to humans through dietary consumption. Here, we observed that cucurbitacin B, a tetracyclic triterpenoid present in pumpkins, gourds and squashes, exhibits antiproliferative effects on human non-small cell lung cancer (NSCLC) cells at nanomolar concentrations. Treatment with cucurbitacin B (0.2-0.6 μM; 24 h) was found to result in decrease in the viability of EGFR-wild type (A549 and H1792) and EGFR-mutant lung cancer cells (H1650 and H1975) and reduction in cell-colonies but had only minimal effect on normal human bronchial epithelial cells...
November 23, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27879277/eukaryotic-translation-initiation-factor-5a2-promotes-metabolic-reprogramming-in-hepatocellular-carcinoma-cells
#2
Ting-Ting Cao, Shu-Hai Lin, Li Fu, Zhi Tang, Chi-Ming Che, Li-Yi Zhang, Xiao-Yan Ming, Teng-Fei Liu, Xu-Ming Tang, Bin-Bin Tan, Di Xiang, Feng Li, On-Yee Chan, Dan Xie, Zongwei Cai, Xin-Yuan Guan
Reprogramming of intracellular metabolism is common in liver cancer cells. Understanding the mechanisms of cell metabolic reprogramming may present a new basis for liver cancer treatment. In our previous study we reported that a novel oncogene eukaryotic translation initiation factor 5A2 (EIF5A2) promotes tumorigenesis under hypoxic condition. Here, we aim to investigate the role of EIF5A2 in cell metabolic reprogramming during hepatocellular carcinoma (HCC) development. In this study, we reported that the mRNA level of EIF5A2 was up-regulated in 59/105 (56...
November 22, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27866157/loss-of-free-fatty-acid-receptor-2-enhances-colonic-adenoma-development-and-reduces-the-chemopreventive-effects-of-black-raspberries-in-apcmin-mice
#3
Pan Pan, Chad W Skaer, Hsin-Tzu Wang, Kiyoko Oshima, Yi-Wen Huang, Jianhua Yu, Jianying Zhang, Martha Yearsley, Kimberle Agle, William Drobyski, Xiao Chen, Li-Shu Wang
We previously showed that black raspberries (BRBs) have beneficial effects in human colorectal cancer and a mouse model of colorectal cancer (Apc(Min/+)). The current study investigated the role of free fatty acid receptor 2 (FFAR2) in colon carcinogenesis and whether the FFAR2 signaling pathway contributes to BRB-mediated chemoprevention in mice. FFAR2 (also named GPR43) is a member of the G-protein-coupled receptor family that is expressed in leukocytes and colon. Apc(Min/+) and Apc(Min/+)-FFAR2(-/-) mice were given a control diet or the control diet supplemented with 5% BRBs for 8 weeks...
November 19, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27866156/hide-and-seek-the-interplay-between-cancer-stem-cells-and-the-immune-system
#4
REVIEW
Mohammad Sultan, Krysta Mila Coyle, Dejan Vidovic, Margaret Lois Thomas, Shashi Gujar, Paola Marcato
The enhanced ability of cancer stem cells (CSCs) to give rise to new tumors suggests that these cells may also have an advantage in evading immune detection and elimination. This tumor-forming ability, combined with the known plasticity of the immune system, which can play both protumorigenic and antitumorigenic roles, has motivated investigations into the interaction between CSCs and the immune system. Herein, we review the interplay between host immunity and CSCs by examining the immune-related mechanisms that favor CSCs and the CSC-mediated expansion of protumorigenic immune cells...
November 19, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27838635/genetic-variants-of-mucins-unexplored-conundrum
#5
REVIEW
Sushil Kumar, Eric Cruz, Suhasini Joshi, Asish Patel, Rahat Jahan, Surinder K Batra, Maneesh Jain
Alternative gene splicing, occurring ubiquitously in multicellular organisms can produce several protein isoforms with putatively different functions. The enormously extended genomic structure of mucin genes characterized by the presence of multiple exons encoding various domains may result in functionally diverse repertoire of mucin proteins due to alternative splicing. Splice variants (Svs) and mutations in mucin genes have been observed in various cancers and shown to participate in cancer progression and metastasis...
November 12, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27838634/frequently-mutated-genes-pathways-and-genomic-instability-as-prevention-targets-in-liver-cancer
#6
REVIEW
Chinthalapally V Rao, Adam S Asch, Hiroshi Y Yamada
The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is common: more than 600000 related deaths are estimated each year. In the USA, about 27170 deaths due to liver cancer are estimated for 2016. Liver cancer is highly resistant to conventional chemotherapy and radiotherapy. For all stages combined, the 5-year survival rate is 15-17%, leaving much to be desired for liver cancer prevention and therapy. Heterogeneity, which can originate from genomic instability, is one reason for poor outcome...
November 12, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27803053/polymorphisms-in-microrna-binding-sites-of-mucin-genes-as-predictors-of-clinical-outcome-in-colorectal-cancer-patients
#7
Veronika Vymetalkova, Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka
Polymorphisms in microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and susceptibility to common diseases. Mucins have been identified as markers of adverse prognosis. We hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival.In the present study, we analyzed the association of single nucleotide polymorphisms in predicted miRNA target sites (miRSNPs) of mucin genes with colorectal cancer (CRC) risk and clinical outcome...
November 1, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27803052/cancer-associated-fibroblasts-regulate-keratinocyte-cell-cell-adhesion-via-tgf-%C3%A3-dependent-pathways-in-genotype-specific-oral-cancer
#8
N Cirillo, Y Hassona, A Celentano, K P Lim, S Manchella, E K Parkinson, S S Prime
The inter-relationship between malignant epithelium and the underlying stroma is recognised as being of fundamental importance in tumour development and progression. In the present study, we used cancer associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), tumours that are characterised by the loss of genes such as TP53 and p16(INK4A) and with extensive LOH, together with CAFs from their more genetically stable counterparts that have wild type TP53 and p16(INK4A) and minimal LOH (GS-OSCC)...
November 1, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27803051/up-regulation-of-mismatch-repair-genes-msh6-pms2-and-mlh1-parallels-development-of-genetic-instability-and-is-linked-to-tumor-aggressiveness-and-early-psa-recurrence-in-prostate-cancer
#9
Waldemar Wilczak, Semin Rashed, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Franziska Büscheck, Till Sebastian Clauditz, Katharina Grupp, Sarah Minner, Maria Christina Tsourlakis, Christina Koop, Markus Graefen, Meike Adam, Alexander Haese, Corinna Wittmer, Guido Sauter, Jakob Robert Izbicki, Hartwig Huland, Thorsten Schlomm, Stefan Steurer, Till Krech, Patrick Lebok
DNA mismatch repair (MMR) is integral to the maintenance of genetic stability. We aimed to evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes MSH6, MLH1 and PMS2 were analyzed by immunohistochemistry on a tissue microarray containing 11 152 prostate cancer specimens. Results were compared with ERG status and deletions of PTEN, 3p13, 5q21, and 6q15. MSH6, MLH1 and PMS2 expression was detectable in 89.5%, 85.4% and 85.0% of cancers, and was particularly strong in cancers with advanced pathological tumor stage (p<0...
November 1, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27797827/anti-inflammatory-natural-product-goniothalamin-reduces-colitis-associated-and-sporadic-colorectal-tumorigenesis
#10
Débora Barbosa Vendramini-Costa, Ralph Francescone, David Posocco, Vivianty Hou, Oxana Dmitrieva, Harvey Hensley, João Ernesto de Carvalho, Ronaldo Aloise Pilli, Sergei Grivennikov
The tumor microenvironment offers multiple targets for cancer therapy, including pro-tumorigenic inflammation. Natural compounds represent an enormous source of new anti-inflammatory and anticancer agents. We previously showed that the styryl lactone goniothalamin (GTN) has promising antiproliferative and anti-inflammatory activities. Because inflammation is a major driver of colorectal cancer (CRC), we therefore evaluated the therapeutic and preventive potentials of GTN in colitis, colitis associated cancer (CAC) and spontaneous CRC...
October 24, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27797826/short-leukocyte-telomere-length-alone-and-in-combination-with-smoking-contributes-to-increased-risk-of-gastric-cancer-or-esophageal-squamous-cell-carcinoma
#11
Wenting Pan, Jiangbo Du, Meng Shi, Guangfu Jin, Ming Yang
In humans, telomeres shorten along with division of somatic cells. Shortened telomere length might result in genomic instability and has been associated with several malignancies. However, the findings in different populations remain conflicting. Therefore, we assessed the association of telomere length in peripheral blood leukocytes with risk of gastric cancer (GC) or esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. A total of 574 GC cases, 740 ESCC cases and 774 age- and sex-matched healthy controls were included in this analysis...
October 24, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27797825/mcm7-and-its-hosted-mir-25-93-and-106b-cluster-elicit-yap-taz-oncogenic-activity-in-lung-cancer
#12
F Lo Sardo, M Forcato, A Sacconi, V Capaci, F Zanconato, S di Agostino, G Del Sal, P P Pandolfi, S Strano, S Bicciato, G Blandino
Lung cancer is the first cause of cancer death worldwide and the Hippo pathway transcriptional coactivators YAP/TAZ have a pro-oncogenic role in this context. In order to understand the mechanisms through which YAP/TAZ elicit their oncogenic role in different systems, many studies are focused on YAP/TAZ target genes involved in the regulation of cell proliferation/survival and migration. However, there is scarce evidence on the role of YAP/TAZ in microRNA regulation while there is increasing evidence supporting the role of microRNAs in the main oncogenic processes...
October 17, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27742690/loss-of-fbp1-facilitates-aggressive-features-of-hepatocellular-carcinoma-cells-through-the-warburg-effect
#13
Juan Yang, Cun Wang, Fengbo Zhao, Xiaoying Luo, Meilin Qin, Einthavy Arunachalam, Zhouhong Ge, Ning Wang, Xuan Deng, Guangzhi Jin, Wenming Cong, Wenxin Qin
Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of FBP1 in hepatocelluar carcinoma (HCC) is still not clear. In this study, we observed that the expression of FBP1 was obviously downregulated in the cell lines and tissues of HCC. Downregulation of FBP1 in HCC tissues was correlated with a lower overall survival rate and had a relatively higher tendency of tumor recurrence (n = 224)...
October 14, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27729375/role-of-p53-in-silibinin-mediated-inhibition-of-ultraviolet-b-radiation-induced-dna-damage-inflammation-and-skin-carcinogenesis
#14
Cynthia M Rigby, Srirupa Roy, Gagan Deep, Ruth Guillermo-Lagae, Anil K Jain, Deepanshi Dhar, David J Orlicky, Chapla Agarwal, Rajesh Agarwal
Non-melanoma skin cancers (NMSC) are a growing problem given that solar UVB radiation exposure is increasing most likely due to depletion of the atmospheric ozone layer and lack of adequate sun protection. Better preventive methods are urgently required to reduce UV-caused photodamage and NMSC incidence. Earlier, we have reported that silibinin treatment activates p53 and reduces photodamage and NMSC, both in vitro and in vivo; but whether silibinin exerts its protective effects primarily through p53 remain unknown...
October 11, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915280/table_of_contents
#15
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December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915279/subscriptions
#16
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December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915278/instructions_to_authors
#17
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December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915277/front_cover
#18
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December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915276/editorial_board
#19
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December 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27915275/back_cover
#20
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December 2016: Carcinogenesis
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