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Carcinogenesis

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https://www.readbyqxmd.com/read/28207072/synergistic-chemopreventive-effects-of-nobiletin-and-atorvastatin-on-colon-carcinogenesis
#1
Xian Wu, Mingyue Song, Peiju Qiu, Kanyasiri Rakariyatham, Fang Li, Zili Gao, Xiaokun Cai, Minqi Wang, Fei Xu, Jinkai Zheng, Hang Xiao
No abstract text is available yet for this article.
February 16, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28203756/erbb4-acts-as-a-suppressor-in-the-development-of-hepatocellular-carcinoma
#2
Yao Liu, Liming Song, Hengli Ni, Lina Sun, Weijuan Jiao, Lin Chen, Qun Zhou, Tong Shen, Hongxia Cui, Tianming Gao, Jianming Li
No abstract text is available yet for this article.
February 16, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28199476/six1-promotes-colorectal-cancer-growth-and-metastasis-by-stimulating-angiogenesis-and-recruiting-tumor-associated-macrophages
#3
Hanwen Xu, Yu Zhang, Maria M Peña, Lucia Pirisi, Kim E Creek
No abstract text is available yet for this article.
February 12, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28186538/elevated-hmgn4-expression-potentiates-thyroid-tumorigenesis
#4
Jamie Kugler, Yuri V Postnikov, Takashi Furusawa, Shioko Kimura, Michael Bustin
No abstract text is available yet for this article.
February 10, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28186269/hypoxia-pathway-genetic-variants-predict-survival-of-non-small-cell-lung-cancer-patients-receiving-platinum-based-chemotherapy
#5
Rong Li, Jiang Gu, John V Heymach, Xiang Shu, Lina Zhao, Baohui Han, Yuanqing Ye, Jack Roth, Xifeng Wu
No abstract text is available yet for this article.
February 10, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28186267/microrna-196b-is-an-independent-prognostic-biomarker-in-patients-with-pancreatic-cancer
#6
Shinichi Kanno, Katsuhiko Nosho, Keisuke Ishigami, Itaru Yamamoto, Hideyuki Koide, Hiroyoshi Kurihara, Kei Mitsuhashi, Masahiro Shitani, Masayo Motoya, Shigeru Sasaki, Tokuma Tanuma, Hiroyuki Maguchi, Tadashi Hasegawa, Yasutoshi Kimura, Ichiro Takemasa, Yasuhisa Shinomura, Hiroshi Nakase
No abstract text is available yet for this article.
February 10, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28182203/cyp2a6-genetic-polymorphisms-and-biomarkers-of-tobacco-smoke-constituents-in-relation-to-risk-of-lung-cancer-in-the-singapore-chinese-health-study
#7
Jian-Min Yuan, Heather H Nelson, Steven G Carmella, Renwei Wang, Jacquelyn Kuriger-Laber, Aizhen Jin, Jennifer Adams-Haduch, Stephen S Hecht, Woon-Puay Koh, Sharon E Murphy
No abstract text is available yet for this article.
February 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28182198/a-time-series-analysis-of-altered-histone-h3-acetylation-and-gene-expression-during-the-course-of-mmaiii-induced-malignant-transformation-of-urinary-bladder-cells
#8
Jinqiu Zhu, Jie Wang, Xushen Chen, Maria Tsompana, Daniel Gaile, Michael Buck, Xuefeng Ren
No abstract text is available yet for this article.
February 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28203752/molecular-profiles-of-benign-and-pre-malignant-endometrial-lesions
#9
Louis J M van der Putten, Renée van Hoof, Bastiaan B J Tops, Marc P L M Snijders, Saskia H van den Berg-van Erp, Anneke A M van der Wurff, Johan Bulten, Johanna M A Pijnenborg, Leon F A G Massuger
No abstract text is available yet for this article.
January 25, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28069693/dna-fragile-site-breakage-as-a-measure-of-chemical-exposure-and-predictor-of-individual-susceptibility-to-form-oncogenic-rearrangements
#10
Christine E Lehman, Laura W Dillon, Yuri E Nikiforov, Yuh-Hwa Wang
Chromosomal rearrangements induced by non-radiation causes contribute to the majority of oncogenic fusions found in cancer. Treatment of human thyroid cells with fragile site-inducing laboratory chemicals can cause preferential DNA breakage at the RET gene and generate the RET/PTC1 rearrangement, a common driver mutation in papillary thyroid carcinomas (PTC). Here, we demonstrate that treatment with non-cytotoxic levels of environmental chemicals (benzene and diethylnitrosamine) or chemotherapeutic agents (etoposide and doxorubicin) generates significant DNA breakage within RET at levels similar to those generated by fragile site-inducing laboratory chemicals...
January 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28069692/genes-involved-in-development-and-differentiation-are-commonly-methylated-in-cancers-derived-from-multiple-organs-a-single-institutional-methylome-analysis-using-1007-tissue-specimens
#11
Kentaro Ohara, Eri Arai, Yoriko Takahashi, Nanako Ito, Ayako Shibuya, Koji Tsuta, Ryoji Kushima, Hitoshi Tsuda, Hidenori Ojima, Hiroyuki Fujimoto, Shun-Ichi Watanabe, Hitoshi Katai, Takayuki Kinoshita, Tatsuhiro Shibata, Takashi Kohno, Yae Kanai
The aim of this study was to clarify the significance of DNA methylation alterations shared by cancers derived from multiple organs. We analyzed single-institutional methylome data by single-CpG-resolution Infinium assay for 1,007 samples of non-cancerous tissue (N) and corresponding cancerous tissue (T) obtained from lung, stomach, kidney, breast and liver. Principal component analysis revealed that N samples of each organ showed distinct DNA methylation profiles, DNA methylation profiles of N samples of each organ being inherited by the corresponding T samples and DNA methylation profiles of T samples being more similar to those of N samples in the same organ than those of T samples in other organs...
January 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28062409/d-mannose-a-novel-prognostic-biomarker-for-patients-with-esophageal-adenocarcinoma
#12
Jianchun Gu, Dong Liang, Jeanne A Pierzynski, Leizhen Zheng, Yuanqing Ye, Jinhua Zhang, Jaffer A Ajani, Xifeng Wu
Metabolomic profiling isa promising approach to identify new biomarkers for cancer prognosis.However, the role of circulating metabolites as prognostic indicators in esophageal adenocarcinoma (EAC) has not been well-explored. In this study, we aimed to evaluatethe prognostic value of three serum metabolites, D-mannose, L-proline (LP), and 3-hydroxybutyrate (BHBA), which were significantly different between EAC patients and controls,identified through a global and targeted metabolite profiling.We measured the levels ofD-mannose, LP, and BHBA in pretreatment serum from 159 EAC patients, using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) methods...
January 6, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28172475/integrated-metabolomics-and-proteomics-highlight-altered-nicotinamide-and-polyamine-pathways-in-lung-adenocarcinoma
#13
Johannes F Fahrmann, Dmitry Grapov, Kwanjeera Wanichthanarak, Brian C DeFelice, Michelle R Salemi, William N Rom, David R Gandara, Brett S Phinney, Oliver Fiehn, Harvey Pass, Suzanne Miyamoto
No abstract text is available yet for this article.
January 3, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28049629/integrated-metabolomics-and-proteomics-highlight-altered-nicotinamide-and-polyamine-pathways-in-lung-adenocarcinoma
#14
REVIEW
Johannes F Fahrmann, Dmitry D Grapov, Kwanjeera Wanichthanarak, Brian C DeFelice, Michelle R Salemi, William N Rom, David R Gandara, Brett S Phinney, Oliver Fiehn, Harvey Pass, Suzanne Miyamoto
Lung cancer is the leading cause of cancer mortality in the United States with non-small cell lung cancer (NSCLC) adenocarcinoma being the most common histological type. Early perturbations in cellular metabolism are a hallmark of cancer, but the extent of these changes in early stage lung adenocarcinoma remains largely unknown. In the current study, an integrated metabolomics and proteomics approach was utilized to characterize the biochemical and molecular alterations between malignant and matched control tissue from 27 subjects diagnosed with early stage lung adenocarcinoma...
January 3, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28039327/a-functional-polymorphism-located-at-transcription-factor-binding-sites-rs6695837-near-lamc1-gene-confers-risk-of-colorectal-cancer-in-chinese-populations
#15
Jiao Lou, Jing Gong, Juntao Ke, Jianbo Tian, Yi Zhang, Jiaoyuan Li, Yang Yang, Ying Zhu, Yajie Gong, Lu Li, Jiang Chang, Rong Zhong, Xiaoping Miao
Genome-wide association studies (GWASs) have identified multiple single nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) susceptibility. However, the elucidation of causal SNPs and the biological mechanisms behind are still limited. In this study, we initially performed systematic bioinformatics analyses on CRC GWAS-identified loci to seek for potential functional SNPs located at transcription factor binding sites (TFBSs), and then a two-stage case-control study comprised of 1353 cases and 1448 controls of Chinese populations and functional analyses were conducted...
December 29, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/28034876/an-indel-polymorphism-within-pre-mir3131-confers-risk-for-hepatocellular-carcinoma
#16
Chaoqun Wang, Lijuan Li, Zhixia Yin, Qing Zhang, Hua Zhao, Ruiyang Tao, Shouyu Wang, Shuxiang Hu, Yan He, Dayong Wang, Chengtao Li, Suhua Zhang, Jiejie Xu, Xinghong Jiang, Shaohua Zhu, Yuzhen Gao
Polymorphisms in pre-miRNAs may affect its expression, then have effect on its target mRNAs and be associated with cancer susceptibility. In this study, we evaluated the association of an indel polymorphism rs57408770 in pre-miR-3131 with hepatocellular carcinoma (HCC) susceptibility in a Chinese population. The contribution of rs57408770 to HCC risk was investigated in two independent case-control sets (1051 HCC and 1058 controls). Logistic regression analysis showed that the insertion allele of rs57408770 was significantly associated with an increased risk for HCC occurrence in both case-control studies...
December 29, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/28174904/prevalence-of-hpv-infection-in-racial-ethnic-subgroups-of-head-and-neck-cancer-patients
#17
Camille Ragin, Jeffrey C Liu, Gieira Jones, Olubunmi Shoyele, Bukola Sowunmi, Rachel Kennett, Denise Gibbs, Elizabeth Blackman, Michael Esan, Margaret S Brandwein, Karthik Devarajan, Francesco Bussu, Rebecca Chernock, Chih-Yen Chien, Marc A Cohen, Samir El-Mofty, Mikio Suzuki, Gypsyamber D'Souza, Pauline Funchain, Charis Eng, Susanne M Gollin, Angela Hong, Yuh-S Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P Worden, Deborah Nelson, Samuel Gathere, Emanuela Taioli
No abstract text is available yet for this article.
December 26, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/28025390/prevalence-of-hpv-infection-in-racial-ethnic-subgroups-of-head-and-neck-cancer-patients
#18
Camille Ragin, Jeffrey C Liu, Gieira Jones, Olubunmi Shoyele, Bukola Sowunmi, Rachel Kennett, Harry J M Groen, Denise Gibbs, Elizabeth Blackman, Michael Esan, Margaret S Brandwein, Karthik Devarajan, Francesco Bussu, Rebecca Chernock, Chih-Yen Chien, Marc A Cohen, El-Mofty Samir, Suzuki Mikio, Gypsyamber D'Souza, Pauline Funchain, Charis Eng, Susanne M Gollin, Angela Hong, Yuh-S Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P Worden, Deborah Nelson, Samuel Gathere, Emanuela Taioli
The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background...
December 26, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/28007956/upregulation-of-rpa2-promotes-nf-%C3%AE%C2%BAb-activation-in-breast-cancer-by-relieving-the-antagonistic-function-of-menin-on-nf-%C3%AE%C2%BAb-regulated-transcription
#19
Chao-Chung Chen, Chi-Wen Juan, Kuan-Yu Chen, Yi-Chien Chang, Janq-Chang Lee, Ming-Chung Chang
RPA2, a subunit of the heterotrimeric replication protein A (RPA) complex, is overexpressed in various cancers. In this study, we showed a significant RPA2 upregulation in breast cancer tissues and cell lines. Ectopic expression of RPA2 in MCF7 and MDA-MB-231 cells promoted cell proliferation, adhesion, migration and invasion, and induced epithelial-mesenchymal transition (EMT) of MCF7 cells. Ablation of RPA2 in MDA-MB-231 cells induced apoptosis and suppressed colony formation, EMT and invasion. Binding assays indicated that menin, the MEN1 (multiple endocrine neoplasia type 1) tumor suppressor gene product, interacted with RPA2...
December 22, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27993896/reexamining-cancer-metabolism-lactate-production-for-carcinogenesis-could-be-the-purpose-and-explanation-of-the-warburg-effect
#20
REVIEW
Iñigo San-Millán, George A Brooks
Herein, we use lessons learned in exercise physiology and metabolism to propose that augmented lactate production ('lactagenesis'), initiated by gene mutations, is the reason and purpose of the Warburg Effect and that dysregulated lactate metabolism and signaling are the key elements in carcinogenesis. Lactate-producing ('lactagenic') cancer cells are characterized by increased aerobic glycolysis and excessive lactate formation, a phenomenon described by Otto Warburg 93 years ago, which still remains unexplained...
December 17, 2016: Carcinogenesis
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