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Lasers in Surgery and Medicine

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https://www.readbyqxmd.com/read/28075022/the-mechanistic-basis-for-photobiomodulation-therapy-of-neuropathic-pain-by-near-infrared-laser-light
#1
Vanessa Milanesi Holanda, Maria Cristina Chavantes, Xingjia Wu, Juanita J Anders
BACKGROUND AND OBJECTIVE: Various irradiances have been reported to be beneficial for the treatment of neuropathic pain with near infrared light. However, the mechanistic basis for the beneficial outcomes may vary based on the level of irradiance or fluence rate used. Using in vivo and in vitro experimental models, this study determined the mechanistic basis of photobiomodulation therapy (PBMT) for the treatment of neuropathic pain using a high irradiance. STUDY DESIGN/MATERIALS AND METHODS: In vitro experiments: Cultured, rat DRG were randomly assigned to control or laser treatment (LT) groups with different irradiation times (2, 5, 30, 60, or 120 seconds)...
January 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28075021/ablative-fractional-laser-resurfacing-a-powerful-tool-to-help-restore-form-and-function-during-international-medical-exchange
#2
LETTER
Carrick Burns, Andrew Basnett, Johannah Valentine, Peter Shumaker
No abstract text is available yet for this article.
January 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28012197/interstitial-photodynamic-therapy-and-glioblastoma-light-fractionation-in-a-preclinical-model
#3
Henri-Arthur Leroy, Maximilien Vermandel, Anne-Sophie Vignion-Dewalle, Bertrand Leroux, Claude-Alain Maurage, Alain Duhamel, Serge Mordon, Nicolas Reyns
BACKGROUND: Glioblastoma is a high-grade cerebral tumor with local recurrence and poor outcome. Photodynamic therapy (PDT) is a localized treatment based on the light activation of a photosensitizer (PS) in the presence of oxygen, which results in the formation of cytotoxic species. The delivery of fractionated light may enhance treatment efficacy by reoxygenating tissues. OBJECTIVE: To evaluate the efficiency of two light-fractionation schemes using immunohistological data...
December 24, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28000244/sensitivity-and-specificity-of-multispectral-imaging-in-detecting-central-serous-chorioretinopathy
#4
Xuemei Zhu, Yong Cheng, Xue Pan, Enzhong Jin, Shanshan Li, Mingwei Zhao, Xiaoxin Li
BACKGROUND AND OBJECTIVE: Central serous chorioretinopathy (CSCR) is a common and idiopathic retinal disorder that affects young to middle aged adults. The aim of this study was to describe the characteristics of eyes with CSCR using a light-emitting diode (LED)-based multispectral imaging (MSI) system and to evaluate the diagnostic reliability of MSI compared to fluorescein angiography (FA) in detecting CSCR. MATERIALS AND METHODS: A total of 56 eyes among 52 patients with 1 or more retinal pigment epithelium (RPE) abnormality were retrospectively enrolled in the study...
December 21, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27990665/clinical-assessment-of-a-new-755%C3%A2-nm-diode-laser-for-hair-removal-efficacy-safety-and-practicality-in-56-patients
#5
Josefina Royo, Javier Moreno-Moraga, Mario A Trelles
BACKGROUND AND OBJECTIVE: Recently, the first diode laser with a wavelength of 755 nm for in-motion hair removal came on the market. The objective of this study was to check its efficacy, safety, and practicality under different options for its use. METHODS: A prospective study in a heterogeneous group of 56 patients who had hair removed from various areas of their bodies using three different treatment methods. Four sessions were scheduled in all cases, with a gap of 3 months between each session...
December 19, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27990658/identification-of-liver-metastases-with-probe-based-confocal-laser-endomicroscopy-at-two-excitation-wavelengths
#6
Crispin Schneider, Sean P Johnson, Kurinchi Gurusamy, Richard J Cook, Adrien E Desjardins, David J Hawkes, Brian R Davidson, Simon Walker-Samuel
BACKGROUND: Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit. MATERIAL AND METHODS: The ability of fluorescent probe-based confocal laser endomicroscopy (pCLE) to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis (CRLM)...
December 19, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27990655/transcutaneous-drug-delivery-by-liposomes-using-fractional-laser-technology
#7
Takahiro Fujimoto, Jian Wang, Kazuki Baba, Yuka Oki, Yuki Hiruta, Masayuki Ito, Shinobu Ito, Hideko Kanazawa
OBJECTIVE: Transdermal delivery of hydrophilic peptides remains a challenge due to their poor cellular uptake and transdermal penetration. We hypothesize that combination of a CO2 fractional laser to enhance percutaneous absorption and liposomes as transdermal carriers would improve skin penetration of hydrophilic drugs. STUDY DESIGN: NA. METHODS: Liposomes were prepared using membrane fusion lipid dioleoylphosphatidylethanolamine, and used to deliver 5-carboxyfluorescein (CF) and fluorescein isothiocyanate-conjugated ovalbumin (OVA-FITC) as model hydrophilic peptide drugs...
December 19, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27885682/fractional-laser-assisted-drug-uptake-impact-of-time-related-topical-application-to-achieve-enhanced-delivery
#8
Christina A Banzhaf, Daniel Thaysen-Petersen, Christiane Bay, Peter A Philipsen, Mette Mogensen, Tarl Prow, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established. The aim of this study, was to investigate the importance of time-related topical application after AFXL exposure and to relate resultant uptake in skin with AFXL channel morphology and skin integrity. STUDY DESIGN/MATERIALS AND METHODS: Buttock skin of healthy volunteers (n = 11) was exposed to 10,600 nm fractional CO2 laser using 5% density, 120 μm beam diameter, 15 mJ pulse energy...
November 25, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27868208/special-issue-on-lasers-in-dentistry
#9
Praveen R Arany, Petra Wilder-Smith
No abstract text is available yet for this article.
November 21, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27862085/rabbit-model-of-tracheal-stenosis-using-cylindrical-diffuser
#10
Hyoung Shin Lee, Sung Won Kim, Chulho Oak, Hyun Wook Kang, Junghwan Oh, Min Jung Jung, Sung Bin Kim, Jun Hee Won, Kang Dae Lee
BACKGROUND AND OBJECTIVE: Variable methods of animal model have been introduced to develop tracheal stenosis. However, none of the prior models allow for predictable determination of the grade of stenosis. This study sought to establish an animal model of tracheal stenosis by using a cylindrical diffuser and to evaluate the feasibility of a reproducible model. STUDY DESIGN/MATERIALS AND METHODS: A cylindrical diffuser was developed to have a 5 mm active segment to emit laser light circumferentially...
November 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27859395/photodynamic-diagnosis-with-5-aminolevulinic-acid-for-intraoperative-detection-of-peritoneal-metastases-of-ovarian-cancer-a-feasibility-and-dose-finding-study
#11
Peter Hillemanns, Pauline Wimberger, Jessica Reif, Herbert Stepp, Rüdiger Klapdor
OBJECTIVE: With a prospective feasibility study, we aimed to analyse the effect of different time points for application and dosage of preoperative oral 5-aminolevulinic acid administration for photodynamic diagnosis of peritoneal metastases in ovarian cancer patients. MATERIALS AND METHODS: In this prospective cohort study patients were randomly divided into three different groups. 5-Aminolevulinic acid was orally administered 3-14 hours before surgery using a dosage of 1 mg/kg, 4-9 hours using 10 mg/kg, and 9-16 hours using 10 mg/kg, respectively...
November 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27859390/stone-tissue-differentiation-for-holmium-laser-lithotripsy-using-autofluorescence-clinical-proof-of-concept-study
#12
Birgit Lange, Dieter Jocham, Ralf Brinkmann, Jens Cordes
BACKGROUND AND OBJECTIVES: Holmium laser lithotripsy is the gold standard for intracorporeal fragmentation of urinary calculi. Usually, a visible beam is superimposed on the IR treatment laser as an aiming beam to guide the surgeon. In vitro tests showed that this aiming beam (532 nm, power <1 mW) excites strong fluorescence on human calculi. Tissue, in contrast, emitted much weaker fluorescence. If this is verified in vivo, the fluorescence signal induced by the aiming beam could be used to implement a feedback loop, preventing the Holmium laser being fired on tissue...
November 12, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27859389/influence-of-gold-nanoparticles-on-wound-healing-treatment-in-rat-model-photobiomodulation-therapy
#13
PikSuan Lau, Noriah Bidin, Shumaila Islam, Wan Norsyuhada Binti Wan Mohd Shukri, Nurlaily Zakaria, Nurfatin Musa, Ganesan Krishnan
BACKGROUND AND OBJECTIVE: The aim of this study is to investigate the effect of gold nanoparticles (AuNPs) in photobiomodulation therapy (PBMT) on wound healing process. MATERIALS AND METHODS: AuNPs are synthesized by Q-switched Nd:YAG laser ablation technique. Cutaneous wound are induced on 45 Sprague Dawley rats on its dorsal part and then randomly divided into three groups. One group serves as non-treatment group (GC) and another two groups are subjected to AuNPs with and without PBMT...
November 12, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27862066/fractional-co2-laser-treatment-of-caesarean-section-scars-a-randomized-controlled-split-scar-trial-with-long-term-follow-up-assessment
#14
Katrine E Karmisholt, Elisabeth H Taudorf, Camilla B Wulff, Emily Wenande, Peter A Philipsen, Merete Haedersdal
BACKGROUND AND OBJECTIVES: Caesarean section (c-section) scars can be pose functional and cosmetic challenges and ablative fractional laser (AFXL) treatment may offer benefit to patients. We evaluated textural and color changes over time in AFXL-treated versus untreated control scars. MATERIALS AND METHODS: A randomized, controlled, intra-individual split-scar trial with three sessions of AFXL-treatments for mature c-section scars. Settings of AFXL were adjusted to each individual scar...
November 8, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27805273/comparison-between-er-yag-laser-and-bipolar-radiofrequency-combined-with-infrared-diode-laser-for-the-treatment-of-acne-scars-differential-expression-of-fibrogenetic-biomolecules-may-be-associated-with-differences-in-efficacy-between-ablative-and-non-ablative
#15
Seonguk Min, Seon Yong Park, Jungyoon Moon, Hyuck Hoon Kwon, Ji Young Yoon, Dae Hun Suh
BACKGROUND AND OBJECTIVE: Fractional Er:YAG minimizes the risk associated with skin ablation. Infrared diode laser and radiofrequency have suggested comparable improvements in acne scar. We compared the clinical efficacy of Er:YAG laser and bipolar radiofrequency combined with diode laser (BRDL) for the treatment of acne scars. Moreover, acute molecular changes of cytokine profile associated with wound healing have been evaluated to suggest mechanisms of improvement of acne scar. STUDY DESIGN: Twenty-four subjects with mild-to-moderate acne scars were treated in a split-face manner with Er:YAG and BRDL, with two treatment sessions, 4 weeks apart...
November 2, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27794165/a-novel-transcutaneous-non-focused-ultrasound-energy-delivering-device-is-able-to-induce-subcutaneous-adipose-tissue-destruction-in-an-animal-model
#16
Assi Levi, Dan Ben Amitai, Moshe Lapidoth
BACKGROUND AND OBJECTIVES: The understanding that adipocytes are greatly influenced by thermal changes combined with the advancement of non-invasive ultrasound technologies have led to the application of ultrasound as an energy source to induce thermal fat destruction. While application of high intensity focused, ultrasound energy have been widely explored, there is far less information regarding the effects of non-focused ultrasound on adipose tissue. The purpose of this study was to characterize the effects of a novel transcutaneous, multi-elements, non-focused ultrasound energy regimen in an animal model, as a proof-of-concept of its potential to treat non-invasive subcutaneous benign tumors...
October 29, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27785787/infrared-laser-sealing-of-porcine-vascular-tissues-using-a-1-470%C3%A2-nm-diode-laser-preliminary-in-vivo-studies
#17
Christopher M Cilip, Duane Kerr, Cassandra A Latimer, Sarah B Rosenbury, Nicholas C Giglio, Thomas C Hutchens, William H Nau, Nathaniel M Fried
INTRODUCTION: Infrared (IR) lasers are being explored as an alternative to radiofrequency (RF) and ultrasonic (US) devices for rapid hemostasis with minimal collateral zones of thermal damage and tissue necrosis. Previously, a 1,470 nm IR laser sealed and cut ex vivo porcine renal arteries of 1-8 mm diameter in 2 seconds, yielding burst pressures greater than 1,200 mmHg and thermal coagulation zones less than 3 mm. This preliminary study describes in vivo testing of a handheld laser probe in a porcine model...
October 27, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27785781/reflectance-confocal-microscopy-of-skin-in-vivo-from-bench-to-bedside
#18
Milind Rajadhyaksha, Ashfaq Marghoob, Anthony Rossi, Allan C Halpern, Kishwer S Nehal
Following more than two decades of effort, reflectance confocal microscopy (RCM) imaging of skin was granted codes for reimbursement by the US Centers for Medicare and Medicaid Services. Dermatologists in the USA have started billing and receiving reimbursement for the imaging procedure and for the reading and interpretation of images. RCM imaging combined with dermoscopic examination is guiding the triage of lesions into those that appear benign, which are being spared from biopsy, against those that appear suspicious, which are then biopsied...
October 27, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27778355/skin-pre-ablation-and-laser-assisted-microjet-injection-for-deep-tissue-penetration
#19
Hun-Jae Jang, Seonggu Yeo, Jack J Yoh
BACKGROUND AND AIMS: For conventional needless injection, there still remain many unresolved issues such as the potential for cross-contamination, poor reliability of targeted delivery dose, and significantly painstaking procedures. As an alternative, the use of microjets generated with Er:YAG laser for delivering small doses with controlled penetration depths has been reported. In this study, a new system with two stages is evaluated for effective transdermal drug delivery. First, the skin is pre-ablated to eliminate the hard outer layer and second, laser-driven microjet penetrates the relatively weaker and freshly exposed epidermis...
October 25, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27778354/leon-goldman-dermatologist-surgeon-pioneer-and-leader-in-laser-surgery-and-medicine-1905-1997
#20
LETTER
Richard C Straight
No abstract text is available yet for this article.
October 25, 2016: Lasers in Surgery and Medicine
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