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Lasers in Surgery and Medicine

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https://www.readbyqxmd.com/read/28815643/early-intervention-with-non-ablative-fractional-laser-to-improve-cutaneous-scarring-a-randomized-controlled-trial-on-the-impact-of-intervention-time-and-fluence-levels
#1
Katrine E Karmisholt, Emily Wenande, Daniel Thaysen-Petersen, Peter A Philipsen, Uwe Paasch, Merete Haedersdal
BACKGROUND AND OBJECTIVES: Laser treatment in the early phases of wound healing may reduce scar formation. However, little is known on when in the early wound healing phases laser exposure most optimally should be provided and at which fluence levels. This study investigates the clinical effect of non-ablative-fractional-laser (NAFL) performed at three early time points at a range of fluence levels versus untreated control scars. MATERIALS AND METHODS: A randomized, controlled, intra-individual trial with erbium-glass 1,540 nm NAFL versus no laser treatment on sixteen subjects receiving 10 standardized full-thickness punch-biopsy wounds...
August 16, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28799650/facial-microcirculatory-and-biomechanical-skin-properties-after-single-high-energy-er-yag-laser-application
#2
Fabian Medved, Antonia Wurm, Manuel Held
OBJECTIVE: Owing to skin aging and the growing demand for skin rejuvenation, minimal invasive aesthetic treatments such as laser procedures are increasingly coming into focus. However, until now, little has been known about the objective effects of these procedures with respect to skin microcirculation or changes in skin elasticity. STUDY DESIGN: Facial skin rejuvenation was performed on 32 volunteers using ablative Erbium: YAG laser. Skin microcirculation and skin elasticity have then been evaluated objectively...
August 11, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28782115/optical-coherence-tomography-image-guided-smart-laser-knife-for-surgery
#3
Nitesh Katta, Austin B McElroy, Arnold D Estrada, Thomas E Milner
BACKGROUND AND OBJECTIVE: Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional surgical laser systems. Tm lasers provide superior beam quality, high volumetric tissue removal rates with minimal residual thermal footprint in tissue, enabling a reduction in unwanted damage to delicate adjacent sub-surface structures such as nerves or micro-vessels...
August 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28759110/effects-of-early-combinatorial-treatment-of-autologous-split-thickness-skin-grafts-in-red-duroc-pig-model-using-pulsed-dye-laser-and-fractional-co2-laser
#4
J Kevin Bailey, Britani N Blackstone, Danielle M DeBruler, Jayne Y Kim, Molly E Baumann, Kevin L McFarland, Folasade O Imeokparia, Dorothy M Supp, Heather M Powell
BACKGROUND AND OBJECTIVE: The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studies report positive outcomes following PDL or FX CO2 therapy, a number of studies have reported no benefit or worsening of the scar following treatment. The objective of this study was to directly compare the efficacy of PDL, FX CO2 , and PDL + FX CO2 laser therapy in reducing scarring post burn injury and autografting in a standardized animal model...
July 31, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28699676/influence-of-multi-wavelength-laser-irradiation-of-enamel-and-dentin-surfaces-at-0-355-2-94-and-9-4%C3%A2-%C3%AE-m-on-surface-morphology-permeability-and-acid-resistance
#5
Nai-Yuan N Chang, Jamison M Jew, Jacob C Simon, Kenneth H Chen, Robert C Lee, William A Fried, Jinny Cho, Cynthia L Darling, Daniel Fried
OBJECTIVE: Ultraviolet (UV) and infrared (IR) lasers can be used to specifically target protein, water, and mineral, respectively, in dental hard tissues to produce varying changes in surface morphology, permeability, reflectivity, and acid resistance. The purpose of this study was to explore the influence of laser irradiation and topical fluoride application on the surface morphology, permeability, reflectivity, and acid resistance of enamel and dentin to shed light on the mechanism of interaction and develop more effective treatments...
July 12, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28699660/binding-of-indocyanine-green-in-polycaprolactone-fibers-using-blend-electrospinning-for-in-vivo-laser-assisted-vascular-anastomosis
#6
Annemarie Schönfeld, Zacharia Mbäıdjol Kabra, Mihai Constantinescu, Dieter Bosshardt, Michael H Stoffel, Kirsten Peters, Martin Frenz
BACKGROUND AND OBJECTIVE: The clinical application of laser-assisted vascular anastomosis is afflicted by unreliable and low bonding strengths as well as tedious handling during microvascular surgery. The challenge to be met arises from the flow-off of the chromophore during soldering that changes the absorption and stains the surrounding tissue, leading to an uncontrollable thermal damage zone. In this study, we investigated the feasibility to produce an indocyanine green (ICG)-loaded patch by electrospinning and tested its applicability to both in vitro and in vivo microvascular laser soldering...
July 12, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28677822/spectroscopic-characterization-of-oral-epithelial-dysplasia-and-squamous-cell-carcinoma-using-multiphoton-autofluorescence-micro-spectroscopy
#7
Rahul Pal, Kert Edward, Liang Ma, Suimin Qiu, Gracie Vargas
OBJECTIVE: Multiphoton autofluorescence microscopy (MPAM) has shown potential in identifying features that are directly related to tissue microstructural and biochemical changes throughout epithelial neoplasia. In this study, we evaluate the autofluorescence spectral characteristics of neoplastic epithelium in dysplasia and oral squamous cell carcinoma (OSCC) using multiphoton autofluorescence spectroscopy (MPAS) in an in vivo hamster model of oral neoplasia in order to identify unique signatures that could be used to delineate normal oral mucosa from neoplasia...
July 5, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28671718/antinociceptive-effects-of-low-level-laser-therapy-at-3-and-8%C3%A2-j-cm-2-in-a-rat-model-of-postoperative-pain-possible-role-of-endogenous-opioids
#8
Fabio C Pereira, Julia R Parisi, Caio B Maglioni, Gabriel B Machado, Paulino Barragán-Iglesias, Josie R T Silva, Marcelo L Silva
Low-level laser therapy (LLLT) is the direct application of light to stimulate cell responses (photobiomodulation) to promote tissue healing, reduce inflammation, and induce analgesia; the molecular basis for these effects of LLLT remains unclear. The objective of this study was to evaluate the analgesic effect of LLLT in the rat plantar incision model of postoperative pain as well as to investigate some of the possible mechanisms involved in this effect. Wistar rats were submitted to plantar incision and treated with LLLT (830 nm, continuous-mode, 30 mW/cm(2) , 1-12 J/cm(2) )...
July 3, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28640436/two-step-irradiance-schedule-versus-single-dose-cold-compress-for-pain-control-during-5-aminolevulinic-acid-based-photodynamic-therapy-of-condyloma-acuminatum
#9
Xiaonan Shao, Fang Wang, Bin Xu
OBJECTIVE: The purpose of this study was to investigate the effect of two-step irradiance schedule in relieving pain during PDT of CA. METHODS: The study was a prospective, controlled trial of 141 CA patients who were randomly divided into Group A (two-step irradiance schedule) and Group B (single-dose cold compress). The numeric rating scales (NRS) of patients' pain were recorded at 5, 10, 15, and 20 minutes during each PDT. RESULTS: The efficacy of PDT and NRS scores of patients in the two groups were compared...
June 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28598555/experimental-and-numerical-investigation-on-the-transient-vascular-thermal-response-to-multi-pulse-nd-yag-laser
#10
Dong Li, Ruohui Li, Hao Jia, Bin Chen, Wenjuan Wu, Zhaoxia Ying
BACKGROUND AND OBJECTIVE: Port wine stains (PWS) are congenital vascular malformations that progressively darken and thicken with age. Laser therapy is currently the most effective way in clinical practice for PWS. A 1,064 nm Nd:YAG laser in the near-infrared band can achieve a deeper treatment depth compared to the current widely adopted pulsed dye laser. However, because of its relatively weak absorption by blood, single-pulse Nd:YAG laser requires high energy density to cause effective vessel damage, but may inflict undesirable burning to surrounding collagen...
June 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28598516/intratumor-cisplatin-nephrotoxicity-in-combined-laser-induced-thermal-therapy-for-cancer-treatment
#11
Marcel N Palumbo, Onivaldo Cervantes, Cecilia Eugênio, Flávia T P Hortense, João C Ribeiro, Ana Amélia P Paolini, Antônio C Tedesco, Joel A Sercarz, Marcos B Paiva
INTRODUCTION: Thermal ablation of tumors by Nd:YAG laser has been growing as a multidisciplinary subspecialty defined as laser-induced thermal therapy (LITT), and has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent cancer. Previous studies have shown that adjuvant chemotherapy can potentiate laser thermal ablation of tumors leading to improved palliation in advanced cancer patients. OBJECTIVE: Evaluate nephrotoxicity by early markers of renal function in treating head and neck cancer using intra-tumor injections of cisplatin combined with laser-induced thermal therapy (CDDP-LITT)...
June 9, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28586092/quantitative-skin-assessment-using-spatial-frequency-domain-imaging-sfdi-in-patients-with-or-at-high-risk-for-pressure-ulcers
#12
Amr Yafi, Fuad K Muakkassa, Tejasvi Pasupneti, Judy Fulton, David J Cuccia, Amaan Mazhar, Kimberly N Blasiole, Eliot N Mostow
BACKGROUND AND OBJECTIVE: Pressure ulcers (PU) are a significant problem facing the health system in the United States. Here, we present preliminary case studies demonstrating feasibility of Spatial Frequency Domain Imaging (SFDI) to assess skin status in high-risk populations and pre-existing wounds. SFDI is a wide-field non-contact optical imaging technology that uses structured light to obtain tissue optical properties and of tissue constituents. This study aims to determine the fit of SFDI for PU care and determine the next steps...
June 6, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28581122/the-application-of-wireless-near-infrared-spectroscopy-on-detecting-peripheral-circulation-in-patients-with-diabetes-foot-ulcer-when-doing-buerger-s-exercise
#13
Min-Ling Chen, Bor-Shyh Lin, Cheng-Wei Su, Yen-Bin Lin, Mei-Yen Chen, Jen-Hsiang Shen, Chang-Cheng Chang
BACKGROUND AND OBJECTIVES: The majority of patients with diabetes foot ulcer have peripheral arterial disease. The technique of near infrared spectroscopy (NIRS) used to monitor the dorsal foot blood circulation condition is by measuring the absorption differences between oxy-hemoglobin and deoxy-hemoglobin. STUDY DESIGNS/MATERIALS AND METHODS: Patients with diabetic foot ulcer (DFU) treated in our wound care center were divided into two sub-groups based on the Duplex ultrasound or angiography...
June 5, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28555933/lentigo-maligna-melanoma-with-a-history-of-cosmetic-treatment-prevalence-surgical-outcomes-and-considerations
#14
Brian P Hibler, Karen L Connolly, Erica H Lee, Anthony M Rossi, Kishwer S Nehal
INTRODUCTION: Lentigo maligna (LM) is melanoma in situ on sun-damaged skin and presents diagnostic challenges due to overlapping features with benign pigmented lesions. Cosmetic treatments may be inadvertently performed on LM. The aim of this study is to estimate the prevalence of LM with prior cosmetic treatment, and evaluate surgical outcomes. STUDY DESIGN AND METHODS: Retrospective review of biopsy-proven LM presenting over a 10-year-period (2006-2015). Prior cosmetic treatment and biopsies were recorded...
May 29, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28548228/skin-reactions-after-photodynamic-therapy-are-unaffected-by-839%C3%A2-nm-photobiomodulation-therapy-a-randomized-double-blind-placebo-controlled-clinical-trial
#15
Christiane Bay, Anne-Cathrine Vissing, Daniel Thaysen-Petersen, Catharina Margrethe Lerche, Katrine Togsverd-Bo, Jakob Heydenreich, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) is associated with erythema and edema. Photobiomodulation (PBM) therapy may stimulate the skin recovery process. We investigated the potential of PBM to reduce PDT-induced skin reactions. STUDY DESIGN AND METHODS: Healthy volunteers (n = 20) were randomized to receive left- or right side PBM (near-infrared 839/595 nm) or placebo-PBM (595 nm) on their buttocks. Corresponding test areas were exposed to standardized PDT reactions, using ablative fractional laser-assisted PDT (AFXL-PDT) with methyl-aminolevulinate (MAL) incubated for 30, 90, and 180 minutes before red-light illumination...
May 26, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28543331/integration-of-optical-applicator-with-balloon-catheter-for-photothermal-treatment-of-biliary-stricture
#16
Jinoh Bak, Jieun Hwang, Suhyun Park, Hyun W Kang
BACKGROUND AND OBJECTIVE: Bile duct stricture is an uncommon disease in gastroenterology resulting from postoperative trauma. In spite of non-surgical treatments, clinical outcomes for the biliary strictures still encounter high restenosis and stent migration. The objective of the current study was to investigate the feasible application of a balloon catheter-integrated diffing applicator to thermally treat the bile duct stricture. MATERIALS AND METHODS: 400-μm optical fibers were micro-machined and then integrated with an inflatable balloon catheter...
May 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28543587/optical-mapping-of-nonmelanoma-skin-cancers-a-pilot-clinical-study
#17
Anna N Yaroslavsky, Xin Feng, Victor A Neel
BACKGROUND AND OBJECTIVE: Nonmelanoma skin cancer (NMSC) is the most common human cancer. Because these tumors often affect the face, there is a strong need for both accurate removal of these neoplasms to prevent recurrence and maximal tissue preservation to prevent cosmetic or functional deformity. Polarization-enhanced reflectance and fluorescence imaging (PERFI) is a new bedside method that uses fluorescent chromophores to image NMSC. While the feasibility of the technique has been successfully demonstrated in ex vivo studies, this is the first pilot study to extend the use of PERFI to in vivo intraoperative imaging of NMSC...
May 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28544068/interstitial-fluid-pressure-a-novel-biomarker-to-monitor-photo-induced-drug-uptake-in-tumor-and-normal-tissues
#18
Sabrina Cavin, Xingyu Wang, Matthieu Zellweger, Michel Gonzalez, Michaël Bensimon, Georges Wagnières, Thorsten Krueger, Hans-Beat Ris, Fabrizio Gronchi, Jean Y Perentes
BACKGROUND: Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts down tumor vessels and enhances normal tissue drug uptake. MATERIAL AND METHODS: In a pleural sarcoma and adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm(2) ) followed by intravenous Lipoplatin® (5 mg/kg) administration...
May 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28714132/news-announcements-american-society-for-laser-medicine-and-surgery-inc
#19
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28333369/in-vivo-multiphoton-microscopy-of-picosecond-laser-induced-optical-breakdown-in-human-skin
#20
Mihaela Balu, Griffin Lentsch, Dorota Z Korta, Karsten König, Kristen M Kelly, Bruce J Tromberg, Christopher B Zachary
IMPORTANCE: Improvements in skin appearance resulting from treatment with fractionated picosecond-lasers have been noted, but optimizing the treatment efficacy depends on a thorough understanding of the specific skin response. The development of non-invasive laser imaging techniques in conjunction with laser therapy can potentially provide feedback for guidance and optimizing clinical outcome. OBJECTIVE: The purpose of this study was to demonstrate the capability of multiphoton microscopy (MPM), a high-resolution, label-free imaging technique, to characterize in vivo the skin response to a fractionated non-ablative picosecond-laser treatment...
August 2017: Lasers in Surgery and Medicine
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