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Lasers in Surgery and Medicine

Luke A Hardy, Viktoriya Vinnichenko, Nathaniel M Fried
OBJECTIVES: The experimental Thulium fiber laser (TFL) is currently being studied as a potential alternative to the gold standard Holmium:YAG laser for lithotripsy. Recent advances in both Holmium and TFL technology allow operation at similar laser parameters for direct comparison. The use of a "dusting" mode with low pulse energy (0.2-0.4 J) and high pulse rate (50-80 Hz) settings, is gaining popularity in lithotripsy due to the desire to produce smaller residual stone fragments during ablation, capable of being spontaneously passed through the urinary tract...
January 16, 2019: Lasers in Surgery and Medicine
Henrik Odéen, Dennis L Parker
OBJECTIVES: To develop, test and evaluate improved 2D and 3D protocols for proton resonance frequency shift magnetic resonance temperature imaging (MRTI) of laser interstitial thermal therapy (LITT). The objective was to develop improved MRTI protocols in terms of temperature measurement precision and volume coverage compared to the 2D MRTI protocol currently used with a commercially available LITT system. METHODS: Four different 2D protocols and four different 3D protocols were investigated...
January 15, 2019: Lasers in Surgery and Medicine
Britt-Isabelle Berg, Michael Peyer, Lorenz Kuske, Marcello Augello, Andreas Schötzau, Markus Steineck, Waldemar Deibel, Daniel Mathys, Philipp Jürgens, Christoph Kunz, David Goldblum
OBJECTIVES: The osteo-odonto-kerato-prosthesis (OOKP) procedure is a complex, multi-stage, multidisciplinary surgical intervention for the treatment of severe corneal blindness. One step of the OOKP consists of creating a precise hole into a tooth in which an optic cylinder is subsequently inserted; its shape must ensure a perfect watertight fit. The Er: YAG laser (L) used in this study is part of CARLO®, the first laser osteotome that enables surgical planning based on computed tomography data, robot guidance, and a precise execution of laser cuts in teeth and bone tissue, using laser photoablation rather than conventional mechanical methods...
January 15, 2019: Lasers in Surgery and Medicine
Deng-Pan Wu, Chun-Hui Ding, Li-Ru Bai, Yan Zhou, Si-Man Yang, Fan Zhang, Jin-Lan Huang
BACKGROUND AND OBJECTIVE: Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32- and Cx26-composed gap junctional intercellular communication (GJIC) could improve the phototoxicity of PDT. However, the role of heterotypic Cx32/Cx26-formed GJIC in PDT phototoxicity is still unknown. Thus, the present study was aimed to investigate the effect of Cx32/Cx26-formed GJIC on PDT efficacy. METHODS: CCK8 assay was used to detect cell survival after PDT...
January 7, 2019: Lasers in Surgery and Medicine
Dongkyun Kang, Dukho Do, Jiheun Ryu, Catriona N Grant, Sarah L Giddings, Mireille Rosenberg, Paul E Hesterberg, Qian Yuan, John J Garber, Aubrey J Katz, Guillermo J Tearney
BACKGROUND AND OBJECTIVE: The tethered spectrally-encoded confocal endomicroscopy (SECM) capsule is an imaging device that once swallowed by an unsedated patient can visualize cellular morphologic changes associated with gastrointestinal (GI) tract diseases in vivo. Recently, we demonstrated a tethered SECM capsule for counting esophageal eosinophils in patients with eosinophilic esophagitis (EoE) in vivo. Yet, the current tethered SECM capsule is far too long to be widely utilized for imaging pediatric patients, who constitute a major portion of the EoE patient population...
January 6, 2019: Lasers in Surgery and Medicine
Toni Karppinen, Emmi Kantola, Ari Karppinen, Antti Rantamäki, Hannu Kautiainen, Serge Mordon, Mircea Guina
OBJECTIVES: The primary objective of this study was to compare a traditional green KTP laser to a new investigational yellow laser (PhotoLase) in the treatment of facial telangiectasia in terms of the treatment outcomes. The secondary objective was to assess the functionality and reliability of the PhotoLase system from the perspective of the user. STUDY DESIGN/METHODS: The study was a randomized split-face double-blinded study that compared the treatment efficacy of the 532-nm KTP laser and the investigational 585-nm PhotoLase laser...
January 6, 2019: Lasers in Surgery and Medicine
Wareeporn Disphanurat, Arisa Kaewkes, Worapop Suthiwartnarueput
OBJECTIVES: Striae distensae are linear atrophic dermal scars. Despite several currently available therapeutic modalities, no consistently effective therapies have been established. This study aimed to evaluate and compare the efficacy of topical recombinant human epidermal growth factor (rhEGF) and ablative fractional carbon dioxide (CO2 ) laser (AFXL) versus ablative fractional CO2 laser and topical Aloe vera gel in treating striae alba. METHODS: A total of 24 participants with striae alba were enrolled...
January 6, 2019: Lasers in Surgery and Medicine
Antonio Scarano, Felice Lorusso, Alessandro Di Cerbo, Alberta Greco Lucchina, Francesco Carinci
OBJECTIVES: Vascularized soft tissue flaps are often harvested from hair-bearing areas, such as the radial forearm or anterolateral thigh, making their use in oral reconstruction problematic due to postoperative hair growth. The presence of intact hair follicles in free tissue transfer and continued hair growth at the recipient site can result in difficulties with oral hygiene, intraoral irritation, food trapping, and patient distress. This study was to evaluate the intraoral efficacy and safety of a diode laser 808 nm when used for hair removal...
January 6, 2019: Lasers in Surgery and Medicine
Richard Rammo, Lisa Scarpace, Tavarekere Nagaraja, Ian Lee
OBJECTIVE: Recurrent meningiomas can prove problematic for treatment, especially if anaplastic, as options are limited primarily to surgery and radiation therapy. Laser interstitial thermal therapy (LITT) is a minimally invasive technique for achieving immediate cytoreduction. This study seeks to determine the utility of LITT in the setting of recurrent meningiomas. MATERIALS AND METHODS: Patients undergoing LITT for tumor treatment at our institution between November 2014 and February 2016 were identified...
December 28, 2018: Lasers in Surgery and Medicine
Xiaoming Zhang, Honghao Jiang, Yamin Zhang, Guichao Ren, Liyun Dong, Jintao Zhu, Yating Tu, Juan Tao, Liu Yang
OBJECTIVES: Although transdermal drug delivery system (TDDS) has been successfully used for delivering small molecules, its application in the delivery of diagnostic antibodies has been limited due to their large size. In this study, we aim to obtain a broad insight in the dynamics of TRITC-conjugated Goat Anti-Mouse IgG (T-IgG) uptake in fractional Er:YAG laser pretreated skin and provide a new technical option for detecting lupus erythematosus (LE) in mice. METHODS: The skins of SD and MRL/lpr mice were treated by fractional Er:YAG laser followed by external application of T-IgG...
December 28, 2018: Lasers in Surgery and Medicine
Christina A Banzhaf, Vinzent K Ortner, Peter A Philipsen, Merete Haedersdal
BACKGROUND: Ablative fractional laser (AFL) increases uptake of topically applied skin agents. The coagulation zone (CZ) surrounding vertically ablated channels may influence uptake of drugs. OBJECTIVES: To investigate impact of CZ thickness on skin fluorescence intensities (FI) of a hydrophilic molecule by means of fluorescence microscopy (FM) and fluorescence confocal microscopy (FCM). Second, to compare FI of hydrophilic and lipophilic test molecules by FCM. STUDY DESIGN/METHODS AND MATERIALS: Microchannels with CZ thicknesses of 0, 20, and 80 µm were generated by microneedles or AFL (10,600 nm)...
December 25, 2018: Lasers in Surgery and Medicine
Maher Al-Muriesh, Xingping Zhang, Qing Wang, Changzheng Huang, Xiangjie An
OBJECTIVE: To evaluate the efficacy of the multisource radiofrequency in periorbital wrinkles treatment using a VISIA imager. METHODS: This is a prospective cohort study involving 30 sites in 15 patients. INCLUSION CRITERIA: healthy subjects with periorbital wrinkles. Patients underwent five treatment sessions for each site using multisource radiofrequency. VISIA imager was used before and after each treatment, and in 12-week follow-up. The wrinkle scores were calculated and compared between baseline and 12-week follow-up...
December 21, 2018: Lasers in Surgery and Medicine
Yasemin Gündoğdu, Hüsnü Alptekin, Pınar Karabağlı, Mustafa Şahin, Hamdi Ş Kilic
BACKGROUND: Femtosecond (fs) Laser Ionisation Mass Spectrometry (fs-LIMS) on colon tissues are described and investigated using ionization/fragmentation processes in details to present a new application in this study. Linear Time of Flight (L-TOF) mass analyzer was utilized to investigate paraffin-embedded human tissue in this study. The effect of fs laser intensity on the spectral characteristics was investigated and interpreted due to mass spectra obtained using 800 nm wavelength with 90 fs pulses at 1 kHz repetition rate...
December 21, 2018: Lasers in Surgery and Medicine
Rosa Abellán, Clara Gómez, Alejandro Iglesias-Linares, Juan Carlos Palma
OBJECTIVES: Poor oral hygiene during treatment with fixed appliances results in plaque accumulation. The presence of bacteria in the gingival crevice triggers an inflammatory reaction in the gingival tissues. The aim of this study was to compare the impact of two preventive treatments, photodynamic therapy (PDT), and ultrasonic scaler (US), on gingival health in patients under fixed orthodontic treatment. METHODS: Twenty orthodontic patients were randomly allocated to two groups: PDT or US...
December 21, 2018: Lasers in Surgery and Medicine
Kristen M Kelly
No abstract text is available yet for this article.
December 18, 2018: Lasers in Surgery and Medicine
Robert A Weiss, Jan Bernardy
OBJECTIVES: While controlled thermal changes in subcutaneous tissue have been used to trigger apoptosis of fat cells and have been proven clinically efficacious, another mechanism of electromagnetic stress suggests that fat apoptosis could be achieved by a non-thermal manner as well. This animal model study investigates the use of a non-invasive high-intensity magnetic field device to induce apoptosis in fat cells. METHODS: Yorkshire pigs (N = 2) received one treatment (30 minutes) in the abdominal area using a High-Intensity Focused Electromagnetic (HIFEM) device...
December 14, 2018: Lasers in Surgery and Medicine
Jusleen Ahluwalia, Mathew M Avram, Arisa E Ortiz
BACKGROUND AND OBJECTIVE: Recent prospective trials have supported treatment of nonfacial BCC with long-pulsed 1064 nm Nd:YAG laser based on short-term histologic clearance rates. Studies have yet to identify the long-term clinical clearance rates of this specific laser therapy for BCC. STUDY DESIGN/MATERIAL AND METHODS: This is a retrospective review of BCC treated with long-pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area...
December 3, 2018: Lasers in Surgery and Medicine
Eric F Bernstein, Kevin Schomacker, Amit Paranjape, Christopher J Jones
OBJECTIVES: The pulsed-dye laser has long been a gold standard in the treatment of poikiloderma of Civatte. Recent advances in pulsed dye laser technology enable output energies 50% higher, enabling beam diameters of up to 15 mm with clinically relevant fluences. In this study, we investigate this new laser for treatment of this condition. MATERIALS AND METHODS: Twenty subjects were enrolled in the study. A total of four treatments were administered at monthly intervals...
November 27, 2018: Lasers in Surgery and Medicine
Jean Paul Meningaud, Mounia SidAhmed-Mezi, Raphaelle Billon, Kessara Rem, Simone La Padula, Barbara Hersant
BACKGROUND AND OBJECTIVE: Striae distensae (SD) are cutaneous lesions that often occur on the breasts, abdomen, hips, and thighs. The aim of this study is to evaluate the effectiveness of a new technique using a non-invasive Er:YAG laser combined with Spatially Modulated Ablation (SMA) module for the treatment of SD. STUDY DESIGN/MATERIALS AND METHODS: This prospective pilot clinical study included 20 patients with skin phototypes I to IV who are affected by SD...
November 27, 2018: Lasers in Surgery and Medicine
Aria Vazirnia, Arisa E Ortiz
Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Therefore, we report the first clinical experience with a novel Dermal Cooling System that provides localized and controlled freezing to benign pigmented lesions. Twenty patients seeking treatment for benign pigmented lesions were treated with the Dermal Cooling System at the laser and cosmetic dermatology clinic at the University of California, San Diego...
November 27, 2018: Lasers in Surgery and Medicine
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