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Lasers in Surgery and Medicine

Alla B Bucharskaya, Galina N Maslyakova, Marina L Chekhonatskaya, Georgy S Terentyuk, Nikita A Navolokin, Boris N Khlebtsov, Nikolai G Khlebtsov, Alexey N Bashkatov, Elina A Genina, Valery V Tuchin
BACKGROUND: The analysis of recent studies on plasmonic photothermal therapy (PPT) after intravenous administration of gold nanorods (GNRs) has demonstrated that the effectiveness of nanoparticle-assisted laser hyperthermia depends on a correct dosage strategy of nanoparticle administration. Accumulation of GNRs in tumor tissue dramatically increases the local heating of the tumor without damage to healthy tissues. However, the optimal doses of GNR intravenous injections (IVIs) for effective accumulation in tumors, and optimal protocols of PPT are not designed yet...
July 19, 2018: Lasers in Surgery and Medicine
Cheng Wang, Shangdong Lv, Aidong Wang, Fabiao Zhang, Binfeng Wang, Yongfu Xu, Yu Zhu, Zheping Fang
OBJECTIVES: Multiple intrahepatic calculi, especially calculi in both sides of the liver, cannot be completely resolved by traditional surgery. In addition, morbidity after liver resection remains high. ERAS programs have been suggested that could relieve surgical stress and accelerate postoperative recovery. This study aimed to evaluate the safety and efficacy of choledocholithotomy combined with holmium laser lithotripsy in the treatment of multiple intrahepatic calculi within ERAS programs...
July 19, 2018: Lasers in Surgery and Medicine
Kenneth H Chan, Daniel Fried
OBJECTIVE: The purpose of this study was to determine the feasibility of image-guided laser ablation of demineralization from tooth occlusal surfaces using coaxial near-infrared (NIR) and CO2 lasers. MATERIALS AND METHODS: A CO2 laser operating at a wavelength of 9.3-μm was combined with a thulium-doped fiber laser operating at 1880-nm for the selective removal of simulated occlusal caries lesions from 10 tooth samples. Serial NIR reflectance images at 1880-nm were used to guide the CO2 laser for image-guided laser ablation...
July 19, 2018: Lasers in Surgery and Medicine
Weston A Ross, Westin M Hill, Kimberly B Hoang, Avra S Laarakker, Brian P Mann, Patrick J Codd
OBJECTIVE: Current surgical instruments for soft tissue resection including neurosurgical procedures rely on the accuracy and precision of the human operator and are fundamentally constrained by the human hand. Automated surgical action with the integration of intraoperative data sources can enable highly accurate and fast tissue manipulation using laser ablation. This study presents the first experiments with a prototype designed for automated tumor resection via laser ablation. We demonstrate targeted soft tissue resection in porcine brain with an integrated device that combines 3D scanning capabilities with a steerable surgical laser and discuss implications for future automated robotic neurosurgical procedures...
July 9, 2018: Lasers in Surgery and Medicine
Philipp Soergel, Johanna Kirschke, Rüdiger Klapdor, Thorsten Derlin, Peter Hillemanns, Hermann Hertel
OBJECTIVE: Sentinel diagnostic in cervical cancer is performed using Technetium-99m-nanocolloid as a radioactive marker with or without patent blue. In the last years, indocyanine green has been evaluated for sentinel diagnostic in different tumor entities. Indocyanine green is a fluorescent molecule which emits a light signal in the near infrared band after excitation. Our study aims to evaluate indocyanine green compared to the gold standard Tc-99m-nanocolloid. MATERIALS AND METHODS: We included patients with early cervical cancer up to FIGO stage IIA with clinically node-negative pelvic sites and the indication for nodal staging in this prospective trial...
July 3, 2018: Lasers in Surgery and Medicine
Colin S Tan, Louis W Lim, Dominic S Ting
No abstract text is available yet for this article.
June 28, 2018: Lasers in Surgery and Medicine
Eleanor E McCabe-Lankford, Theodore L Brown, Nicole H Levi-Polyachenko
OBJECTIVE: Photothermal therapy (PTT) uses light absorbing materials to generate heat for treatment of diseases, like cancer. The advantages of using PTT components that absorb in the near-infrared (NIR) include reduced tissue auto-fluorescence and higher penetration depths. However, NIR laser light can still be scattered and absorbed by biological tissues, thus decreasing the amount of the energy reaching the PTT agents. We have developed two distinct formulations of NIR-absorbing nanoparticles, one which can be utilized for PTT only, and another for both PTT and fluorescence imaging of colorectal cancer...
June 28, 2018: Lasers in Surgery and Medicine
Ramya Vangipuram, Selina S Hamill, Paul M Friedman
BACKGROUND: Conventional tattoo removal consists of single-pass treatments, spaced 7-8 weeks apart, for a total of 7-10 sessions. A major limiting factor of this procedure is the development of cavitation bubbles and vacuoles within the epidermis and dermis that result from the rapid heating of tattoo particles by the laser. While multiple-pass methods using the R20 protocol or the PFD patch enhance tattoo removal through epidermal clearance, they have no effect on deep-intradermal pigment associated vacuoles that arise from treatment with lasers such as the Q-switched laser...
June 25, 2018: Lasers in Surgery and Medicine
Anne-Cathrine E Vissing, Christine Dierickx, Katrine E Karmisholt, Merete Haedersdal
BACKGROUND: Laser and intense pulsed light (IPL) are standard symptomatic treatments for superficial telangiectasias, but postoperative erythema, oedema, and pain may prolong downtime. OBJECTIVES: To investigate whether topical brimonidine reduces IPL-induced inflammation in patients with moderate to severe facial telangiectasias. METHODS: A randomized, two-centre, single-blinded, split-face trial on adjuvant brimonidine and air-cooling versus air-cooling alone (control) in 19 patients treated in Denmark (n = 10 patients) and Belgium (n = 9)...
June 17, 2018: Lasers in Surgery and Medicine
Elisabeth Datz, Carmen Schönberger, Florian Zeman, Michael Koller, Mark Berneburg, Michael Landthaler, Sigrid Karrer, Ulrich Hohenleutner, Silvia Hohenleutner
BACKGROUND: Fractional ablative resurfacing is frequently used for treating atrophic and acne scars as well as for the early improvement of scars after surgery. No evidence-based clinical data on improving the appearance of skin grafts by fractional CO2 -laser resurfacing have been available so far. OBJECTIVES: The primary outcome parameter was the adaptation of the skin graft to the surrounding skin 2, 6, and 12 months after the second laser treatment. Secondary outcome parameters were melanin variation, skin roughness, resizing of the skin graft, and patient satisfaction with cosmetic results...
June 17, 2018: Lasers in Surgery and Medicine
Pooyan Rohani, Anna N Yaroslavsky, Xin Feng, Peter Jermain, Tarek Shaath, Victor A Neel
INTRODUCTION AND OBJECTIVE: Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States. Surgery is the most common treatment for these tumors, but pre-operative identification of surgical margins is challenging. The objective in this study was to determine whether optical polarization imaging (OPI) could be used prior to surgery to detect the extent of subclinical tumor spread by monitoring disruption in collagen. MATERIALS AND METHODS: OPI is a non-invasive and rapid imaging modality that highlights the structure of dermal collagen...
June 14, 2018: Lasers in Surgery and Medicine
Jing-Yu Min, Yanan Lv, Suqin Yu, Yuan-Yuan Gong
PURPOSE: The present study analyzed the appearances of optical coherence tomography angiography (OCTA) in patients with central serous chorioretinopathy (CSC) based on fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHOD: In the current case series, 54 eyes of 50 patients diagnosed as CSC were evaluated retrospectively. OCTA, FA, and ICGA were performed on each patient. Two trained observers examined the OCTA images independently to confirm and compare the choriocapillary appearance with that on FA/ICGA...
June 12, 2018: Lasers in Surgery and Medicine
Martin J C van Gemert, Paul R Bloemen, Wei-Yong Wang, Cees W M van der Geld, Rudy M M A Nuijts, Hayri Hortoglu, Albert Wolkerstorfer, Daniel M de Bruin, Ton G van Leeuwen, H A Martino Neumann, Martine J Jager
BACKGROUND AND OBJECTIVES: A 36-year-old woman underwent CO2 laser resurfacing for periocular rhytides using protective stainless steel Cox II ocular shields. Immediately after the treatment, corneal lesions were seen in both eyes. The left eye subsequent developed corneal ulceration and scarring, a deformed iris, cataract, and lower eye lashes showing signs of acute burns. The right cornea had a small inferior mid-peripheral superficial lesion and concomitant lower mid-peripheral burned eye lashes...
June 8, 2018: Lasers in Surgery and Medicine
William Lewis, Walfre Franco
OBJECTIVE: The identification of veins by medical personnel is a critical skill that is necessary to draw blood or administer intravenous fluids and medications. Because a normal consumer camera can act as a multispectral imaging apparatus, operating with three broadband detectors, we hypothesized that a standard smartphone camera might be employed for enhanced visualization of veins in human skin. STUDY: Video and images of subcutaneous veins were acquired using the rear-facing iSight camera from an iPhone 6, with a fixed aperture of f/2...
June 6, 2018: Lasers in Surgery and Medicine
George David Baxter, Lizhou Liu, Steve Tumilty, Simone Petrich, Cathy Chapple, Juanita J Anders
OBJECTIVES: This study aimed to determine the feasibility of conducting a full scale randomized controlled trial investigating the effectiveness of low level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, used in addition to conventional therapy, for managing breast cancer related lymphedema (BCRL). MATERIALS AND METHODS: Patients with BCRL were recruited from the Southern District Health Board (New Zealand) via lymphedema therapists' referrals, and randomly allocated into either the laser group, which received BCRL conventional therapy (e...
May 30, 2018: Lasers in Surgery and Medicine
Edward V Ross, Omar A Ibrahimi, Suzanne Kilmer
OBJECTIVE: The purpose of this study was to determine the efficacy and safety of a 1060 nm diode laser system with multiple handpieces for permanent hair reduction. STUDY DESIGN: An open-label, prospective, multi-center study of adult subjects (≥18 years old) of any skin type, having dark brown or black hairs at the areas to be treated and seeking to permanently remove hair underwent six treatment sessions, at 4 to 6 weeks intervals with either a 1060 nm chilled sapphire tip or seven treatment sessions, at 6 weeks interval with a large spot vacuum based handpiece...
May 30, 2018: Lasers in Surgery and Medicine
Stefania Maraka, Karam Asmaro, Tobias Walbert, Ian Lee
OBJECTIVE: Laser interstitial thermal therapy (LITT) is an image-guided technique that uses high temperature to ablate pathological tissue. Brain tumor patients undergoing LITT may also undergo radiation therapy (RT) either before or after LITT. Both procedures have been reported to increase cerebral edema and thereby the two treatments in close succession may worsen existing edema that can be difficult to control. The purpose of our study was to determine the frequency of increased and/or symptomatic cerebral edema after combined LITT and RT, the radiographic and clinical signs of this cerebral edema, and the treatment required...
May 25, 2018: Lasers in Surgery and Medicine
Shaojie Men, Jennifer Manyu Wong, Emily J Welch, Jingjiang Xu, Shaozhen Song, Anthony J Deegan, Aarthi Ravichander, Benjamin Casavant, Erwin Berthier, Ruikang K Wang
OBJECTIVES: To measure and compare microvascular responses within the skin of the upper arm to local stimuli, such as heating or rubbing, through the use of optical coherence tomography angiography (OCTA), and to investigate its impact on blood volume collection. MATERIALS AND METHODS: With the use of heat packs or rubbing, local stimulation was applied to the skin of either the left or right upper arm. Data from the stimulated sites were obtained using OCTA comparing pre- and post-stimulation microvascular parameters, such as vessel density, mean vessel diameter, and mean avascular pore size...
May 25, 2018: Lasers in Surgery and Medicine
Michael Evers, Linh Ha, Malte Casper, David Welford, Garuna Kositratna, Reginald Birngruber, Dieter Manstein
BACKGROUND: Traditionally, fractional laser treatments are performed with focused laser sources operating at a fixed wavelength. Using a tunable laser in the mid-infrared wavelength range, wavelength-dependent absorption properties on the ablation process and thermal damage formation were assessed with the goal to obtain customizable tissue ablations to provide guidance in finding optimized laser exposure parameters for clinical applications. METHODS: Laser tissue experiments were carried out on full thickness ex vivo human abdominal skin using a mid-infrared tunable chromium-doped zinc selenide/sulfide chalcogenide laser...
May 25, 2018: Lasers in Surgery and Medicine
Eric F Bernstein, Jayant Bhawalkar, Kevin T Schomacker
BACKGROUND: Green, blue, and purple tattoo pigments are often the colors most resistant to laser removal. Recently, the first ever production picosecond-domain laser with a 785 nm wavelength was developed to improve the rate of clearance of green, blue, and purple tattoo inks. METHODS: Twenty-two tattoos from 15 subjects with skin phototypes II-IV were enrolled in the study. A total of four treatments were administered using a single 785 nm picosecond-domain laser wavelength...
May 20, 2018: Lasers in Surgery and Medicine
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