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Lasers in Surgery and Medicine

Yona Tadir, Cheryl Iglesia, Macrene Alexiades, G Willy Davila, Nathan Guerette, Adrian Gaspar
No abstract text is available yet for this article.
November 8, 2018: Lasers in Surgery and Medicine
Jung Min Lim, Yeongjoo Oh, Si-Hyung Lee, Mi Yeon Cho, Kee Yang Chung, Mi Ryung Roh
OBJECTIVES: For small to medium sized congenital melanocytic nevi (CMN), the treatment of choice is staged surgical excision. Ablative lasers or pigment-specific lasers have also been recommended for lesions difficult for surgical removal or to avoid surgery. In this study, we retrospectively analyzed the results of several treatment options for CMN to find out the optimal treatment method. METHODS: Patients with small to medium sized CMN were retrospectively reviewed...
October 30, 2018: Lasers in Surgery and Medicine
Lauren M Bonati, Nicola A Quatrano, Mona Sadeghpour, Kenneth A Arndt, Jeffrey S Dover
OBJECTIVE: This retrospective study compares subject-reported pain levels and expectations set forth by industry and treating physicians during a clinical trial of an energy based device. The physiologic and emotional aspects of pain expectations are discussed and recommendations are made for strategic patient counseling. MATERIALS AND METHODS: Average and mode pain scores were collected from the records of a previously conducted clinical trial investigating a radiofrequency microneedling device at three different settings...
October 30, 2018: Lasers in Surgery and Medicine
Ka-Yee Kung, Samantha Y-N Shek, Chi K Yeung, Henry H-L Chan
BACKGROUND AND OBJECTIVES: Cutaneous pigmentary disorders are both more common and more difficult to treat in patients with skin color given the higher melanin content in the epidermis. Although Q-switched lasers are widely considered to be the standard treatment for both epidermal and dermal pigmentary conditions, a very high risk of post-inflammatory hyperpigmentation (PIH) of up to 25% is seen in patients with skin of color. Recently, the novel picosecond laser with pulse durations operating at sub-nanosecond domains has been shown to be effective in tattoo removal and in the treatment of acne scars...
October 25, 2018: Lasers in Surgery and Medicine
Da Jung Jo, In-Hye Kang, Ji Hwoon Baek, Min Jae Gwak, Sang Jun Lee, Min Kyung Shin
OBJECTIVES: Melasma is an acquired type of hyperpigmentation that is characterized by the appearance of scattered light- to dark-brown macules and patches on the face. Recently, several lasers have been proposed as treatment options for melasma. In particular, the picosecond alexandrite laser is an ideal laser for selective photothermal melanolysis. The aim of our study was to compare the effectiveness in melanolysis of a single treatment of the picosecond alexandrite laser with that of the Q-switched Nd:YAG laser using reflectance confocal microscopy imaging of the melasma lesions...
October 23, 2018: Lasers in Surgery and Medicine
Adam B Raff, Carina N Thomas, Gary S Chuang, Mathew M Avram, Monica H Le, R Rox Anderson, Martin Purschke
OBJECTIVE: Lidocaine acts as a local anesthetic by blocking transmembrane sodium channel permeability, but also induces the synthesis of heat shock proteins and sensitizes cells to hyperthermia. A previous study reported two cases of deep focal skin ulceration at points corresponding to depot local lidocaine injection sites after treatment with non-ablative fractional resurfacing and it was hypothesized that lidocaine had focally sensitized keratinocytes to the thermal damage of laser treatment...
October 15, 2018: Lasers in Surgery and Medicine
Jessica G Labadie, Aleksandar L Krunic
BACKGROUND: In the recent past, long pulsed dye lasers (LPDL) have been investigated for the treatment of epidermal pigmented lesions (EPLs). Using a pigmented lesion compression headpiece, blood is pushed laterally out of the laser field focusing laser energy on melanin. Recent studies have demonstrated excellent responses using a single-pulse at the following settings: 9-12 J/cm2 , 1.5 milliseconds, 7-10 mm spot size with compression. However, the majority of these studies report patients requiring up to four treatments for lesion resolution...
October 15, 2018: Lasers in Surgery and Medicine
Or Friedman, Amir Koren, Roni Niv, Joseph N Mehrabi, Ofir Artzi
PURPOSE: Rosacea is a common, chronic facial skin disease that affects the quality of life. Treatment of facial erythema with intradermal botulinum toxin injection has previously been reported. The primary objective of the study was the safety and efficacy of thermal decomposition of the stratum corneum using a novel non-laser thermomechanical system (Tixel, Novoxel, Israel) to increase skin permeability for Botulinum toxin in the treatment of facial flushing of rosacea. METHODS: A retrospective review of16 patients aged 23-45 years with Fitzpatrick Skin Types II to IV and facial erythematotelangiectatic rosacea treated by Tixel followed by topical application of 100 U of abobotulinumtoxin...
October 12, 2018: Lasers in Surgery and Medicine
Ramya Vangipuram, Selina S Hamill, Paul M Friedman
BACKGROUND: The topical transparent perfluorodecalin-infused (PFD) silicone patch has been demonstrated to reduce epidermal whitening produced in association with laser-assisted tattoo removal. This optical clearing agent has enabled multiple laser passes to be made in one treatment session. Previous studies using the PFD patch have showed enhanced clearance with picosecond and Q-Switched lasers on blue/black tattoos in Fitzpatrick skin types I-III. We sought to explore the safety and efficacy of using the PFD patch with Q-Switched and picosecond lasers in Fitzpatrick skin types IV-VI...
October 12, 2018: Lasers in Surgery and Medicine
Timothy Sowers, Don VanderLaan, Andrei Karpiouk, Eleanor M Donnelly, Ethan Smith, Stanislav Emelianov
OBJECTIVES: Intravascular photoacoustic (IVPA) imaging is being developed to image atherosclerotic plaques, a leading cause of morbidity and mortality in the United States. However, the safety of this imaging modality, which requires repeated irradiation with short laser pulses, has not yet been investigated. This study has two objectives. First, determine in vitro the limit of cumulative fluence that can be applied to cells before death at IVPA relevant wavelengths. Second, evaluate if high single pulse fluences are a potential cause of cell death during IVPA imaging...
October 10, 2018: Lasers in Surgery and Medicine
Brian M Kinney, Paula Lozanova
OBJECTIVES: This study introduces an initial evaluation of a novel High-Intensity Focused Electromagnetic (HIFEM) technology. The primary goal is to quantify any effects the treatments may have on abdominal tissues, as well as to establish hypotheses for future research of this technology. METHODS: Twenty-two patients received four abdominal treatments using the EMSCULPT device (BTL Industries Inc., Boston, MA). Anthropometric evaluations were recorded and digital photographs were taken at baseline, at 2 months, and at 6 months post-treatments...
October 10, 2018: Lasers in Surgery and Medicine
Anna-Theresa Seitz, Helen Sterz, Vincent Strehlow, Stephanie Nagel, Konstantin Dumann, Sonja Grunewald, Jan C Simon, Manfred Kunz
Dowling-Degos disease (DDD) is a rare autosomal-dominant genodermatosis with limited treatment possibilities. Although the efficacy of ablative laser therapy has been reported, we sought to examine the efficacy of fractional versus full ablative laser therapy in a female patient with DDD in a split-side report. We treated the lesions on the right side of the patient's upper abdomen with an ablative fractional CO2 laser and the lesions on the left side of the upper abdomen with a full ablative Er:YAG laser (erbium-doped yttrium aluminium garnet laser) three times at monthly intervals...
October 3, 2018: Lasers in Surgery and Medicine
Jessica Lin, Inga Saknite, Manuel Valdebran, Mihaela Balu, Griffin Lentsch, Joshua N Williams, Karsten Koenig, Bruce J Tromberg, Natasha Atanaskova Mesinkovska
OBJECTIVES: Non-invasive visualization of hair follicles is important for proper diagnosis and management of alopecia; however, histological assessment remains the gold standard. Laser imaging technologies have made possible noninvasive in vivo evaluation of skin and hair follicle. The aim of this study was to evaluate the ability of multiphoton microscopy (MPM) to non-invasively identify morphological features that can distinguish scarring from non-scarring alopecia. METHODS: MPM images were obtained from areas on the scalp affected by alopecia...
September 24, 2018: Lasers in Surgery and Medicine
Xiaolan Feng, Yin Shi, Lifen Xie, Kun Zhang, Xiaobing Wang, Quanhong Liu, Pan Wang
OBJECTIVES: Compared to normal cells, malignant cells have a high degree of aerobic glycolysis, also known as the Warburg effect. Therefore, supplementing photodynamic therapy (PDT), an established cancer therapy, with metabolic inhibitors can augment the mitochondrial damage by depleting ATP. To assess the combined impact of the glycolysis inhibitor 2-deoxy-D-glucose (2-DG) and PDT on apoptosis and autophagy in human breast cancer cells, and examine the molecular basis. METHODS: Calcium-AM/PI double staining was used to evaluate cell viability...
September 17, 2018: Lasers in Surgery and Medicine
Paolo Cassano, Christina Dording, Garrett Thomas, Simmie Foster, Albert Yeung, Mai Uchida, Michael R Hamblin, Eric Bui, Maurizio Fava, David Mischoulon, Dan V Iosifescu
OBJECTIVES: Transcranial photobiomodulation (t-PBM) consists of the delivery of near-infrared (NIR) or red light to the scalp designed to penetrate to subjacent cortical areas of the brain. NIR t-PBM has recently emerged as a potential therapy for brain disorders. This study assessed the efficacy of repeated sessions of NIR t-PBM on sexual dysfunction. METHODS: We performed a secondary analysis of a double-blind clinical trial on t-PBM for major depressive disorder (MDD)...
September 17, 2018: Lasers in Surgery and Medicine
Hui Liu, Liam Daly, Grant Rudd, Amjad P Khan, Srivalleesha Mallidi, Yiran Liu, Filip Cuckov, Tayyaba Hasan, Jonathan P Celli
BACKGROUND: Photodynamic therapy (PDT) using δ-aminolevulinic acid (ALA) photosensitization has shown promise in clinical studies for the treatment of early-stage oral malignancies with fewer potential side effects than traditional therapies. Light delivery to oral lesions can also carried out with limited medical infrastructure suggesting the potential for implementation of PDT in global health settings. OBJECTIVES: We sought to develop a cost-effective, battery-powered, fiber-coupled PDT system suitable for intraoral light delivery enabled by smartphone interface and embedded electronics for ease of operation...
August 31, 2018: Lasers in Surgery and Medicine
Irene Castellano-Pellicena, Natallia E Uzunbajakava, Charles Mignon, Bianca Raafs, Vladimir A Botchkarev, M Julie Thornton
BACKGROUND AND OBJECTIVE: Visible light has beneficial effects on cutaneous wound healing, but the role of potential photoreceptors in human skin is unknown. In addition, inconsistency in the parameters of blue and red light-based therapies for skin conditions makes interpretation difficult. Red light can activate cytochrome c oxidase and has been proposed as a wound healing therapy. UV-blue light can activate Opsin 1-SW, Opsin 2, Opsin 3, Opsin 4, and Opsin 5 receptors, triggering biological responses, but their role in human skin physiology is unclear...
August 31, 2018: Lasers in Surgery and Medicine
Heidi Wat, Samantha Yee-Nam Shek, Chi Keung Yeung, Henry Hin-Lee Chan
BACKGROUND AND OBJECTIVES: The picosecond alexandrite laser with diffractive lens array (DLA) offers the dual advantages of a picosecond pulse duration and the fractionated delivery of laser energy. This study explores the efficacy and safety of the DLA for treatment of multiple aesthetic concerns associated with photoaging of the face including skin texture irregularities, dyspigmentation, enlarged pore size, rhytides, and skin laxity. METHODS: This prospective, evaluator-blinded trial enrolled Fitzpatrick skin type III-IV patients with mild to moderate signs of facial photoaging...
August 28, 2018: Lasers in Surgery and Medicine
Uffe H Olesen, Gael Clergeaud, Catharina M Lerche, Thomas L Andresen, Merete Haedersdal
BACKGROUND AND OBJECTIVE: Hedgehog inhibitors such as vismodegib are targeted drugs widely used for the treatment of basal cell carcinomas; however, their use is significantly limited by frequent systemic side effects due to oral administration route. We aim to use ablative fractional laser (AFL) to enable the topical delivery of vismodegib to relevant dermal depths. MATERIALS AND METHODS: Pig skin was treated in vitro with a fractional 10,600 nm CO2 laser at 0 or 80 mJ/microbeam and exposed to vismodegib (6...
August 28, 2018: Lasers in Surgery and Medicine
William Yao, Edward C Kuan, Young Hun Chung, Nathan C Francis, Maie A St John, Zachary D Taylor, Warren S Grundfest
Background and Objectives Laser generated shockwave (LGS) is a novel modality for minimally invasive disruption of bacterial biofilms. The objectives of this study are to determine the mechanisms behind LGS treatment and non-biofilm effects on bacterial disruption, including (1) comparing bacterial load with and without LGS in its planktonic form and (2) estimating bacterial cell permeability following LGS. Study Design/Materials and Methods For the first study, planktonic S. epidermidis were treated with gentamicin (0, 8, 16, 32, 64 μg/ml) with and without LGS (1064 nm Nd:YAG laser, 110...
August 28, 2018: Lasers in Surgery and Medicine
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