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Journal of Hospital Infection

John Chewins
No abstract text is available yet for this article.
May 15, 2018: Journal of Hospital Infection
Nantasit Luangasanatip, Maliwan Hongsuwan, Yoel Lubell, Direk Limmathurotsakul, Pramot Srisamang, Nicholas Pj Day, Nicholas Graves, Ben S Cooper
BACKGROUND: Multimodal interventions are effective in increasing hand hygiene (HH) compliance amongst healthcare workers, but it is not known whether such interventions are cost-effective outside high-income countries. AIM: To evaluate the cost-effectiveness of multimodal hospital interventions to improve hand hygiene (HH) compliance in a middle-income country. METHOD: We adopted a conservative approach by developing a model to determine whether reductions in Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSI) alone would make HH interventions cost-effective in intensive care units (ICUs)...
May 15, 2018: Journal of Hospital Infection
Nikki Kenters, Thomas Gottlieb, Joost Hopman, Shaheen Mehtar, Marin L Schweizer, Ermira Tartari, E G W Huijskens, Andreas Voss
BACKGROUND: Antimicrobial resistance has become an urgent global health priority. Basic hygiene practices and cleaning and disinfection of the hospital environment are key in preventing pathogen cross-transmission. AIM: To our knowledge no studies have assessed the worldwide differences in cleaning and disinfection practices in healthcare facilities. The electronic survey described here was developed in order to evaluate differences in healthcare facility cleaning practices around the world...
May 14, 2018: Journal of Hospital Infection
Dandan Yin, Lei Zhang, Aimin Wang, Leiyan He, Yun Cao, Fupin Hu, Chuanqing Wang
BACKGROUND: The spread of carbapenem-resistant Klebsiella pneumoniae (CR-KPN) is a major concern, but data on CR-KPN infection/colonization in paediatric populations are limited. AIM: This study aimed to analyze epidemiologic and clinical characteristics, therapeutic options of CR-KPN infections in neonates in China. METHODS: A retrospective study was performed at the Children's Hospital of Fudan University, including 88 neonates with CR-KPN admitted between November 2015 and October 2016...
May 12, 2018: Journal of Hospital Infection
Kerry L Holden, Craig W Bradley, Evonne T Curran, Christopher Pollard, Grace Smith, Elisabeth Holden, Patricia Glynn, Mark Garvey
BACKGROUND: Mycobacterium tuberculosis is a major health burden worldwide. The disease can present as an individual case, community outbreak or more rarely a nosocomial outbreak. Even in countries with a low prevalence such as the UK, tuberculosis (TB) presents a risk to healthcare workers (HCWs). AIM: To report an outbreak which manifested 12 months after a patient with pulmonary tuberculosis was admitted to Queen Elizabeth Hospital Birmingham (QEHB). METHODS: We present the epidemiological and outbreak investigations; the role of whole genome sequencing (WGS) in identifying the outbreak and control measures to prevent further outbreaks...
May 9, 2018: Journal of Hospital Infection
Francisco Álvarez-Lerma, Pedro Olaechea-Astigarraga, Mercedes Palomar-Martínez, Mercedes Catalan, Xavier Nuvials, Ricardo Gimeno, María Pilar Gracia Arnillas, Iratxe Seijas Betolaza
We assessed invasive device-associated infections caused by Pseudomonas aeruginosa over 10 years (2007-2016) based on data from the ENVIN-HELICS registry (200 Spanish ICUs). P. aeruginosa was the leading pathogen except in the last two years in which there was a slight decrease, with Escherichia coli as the leading etiology. The rate of infections caused by P. aeruginosa remained between 12.0% and 14.6% throughout the study period. There was a significant increase of isolates resistant to imipenem, meropenem, ceftazidime, cefepime and piperacillin-tazobactam...
May 8, 2018: Journal of Hospital Infection
Neal D Goldstein, Samuel M Jenness, Deborah Tuttle, Michelle Power, David A Paul, Stephen C Eppes
BACKGROUND: Surveillance for meticillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units (NICUs) is a commonplace infection prevention strategy, yet the optimal frequency with which to monitor the unit is unknown. AIM: We compared varying surveillance frequencies via simulation modelling. METHODS: One hundred NICU networks of 52 infants were simulated over a 6-month period to assess MRSA transmission. Unit-wide surveillance occurred every N weeks where N={1,2,3,4}, and was compared against the current NICU policy of dynamic surveillance: weekly when ≥1 positive screen, otherwise every 3 weeks...
May 8, 2018: Journal of Hospital Infection
D A Enoch, R Santos, C J Phillips, C Micallef, M Murphy, S H Aliyu, D Massey, N M Brown
We reviewed all courses of fidaxomicin use in our hospital. It was used for first recurrence (6 times), second recurrence (8) and third recurrence (once). One received fidaxomicin first-line. Eight patients initially responded to therapy. Three of these were asymptomatic at 90 days; three remained asymptomatic at 30 days and two had recurrences 5 and 9 days after stopping therapy. Four patients failed to respond; two required faecal transplantation and one required a colectomy. Two patients deteriorated and two patients died...
May 7, 2018: Journal of Hospital Infection
M Grabowski, J M Lobo, B Gunnell, K Enfield, R Carpenter, L Barnes, A Mathers
BACKGROUND: Handwashing sink drains are increasingly implicated as a potential reservoir of antibiotic-resistant bacteria in hospital outbreaks; however, usage patterns that may promote this source remain unknown. AIM: To understand behaviours in the intensive care unit (ICU) that may facilitate establishment and nosocomial transmission of multidrug-resistant Gram negatives from a sink-trap reservoir to a patient. METHODS: Motion-sensitive cameras captured anonymized activity paired with periodic in-person observations during a quality investigation from four ICU sinks (two patient rooms and two patient bathrooms) in a university hospital...
May 5, 2018: Journal of Hospital Infection
J Schuurmans, S P Lutgens, L Groen, P M Schneeberger
BACKGROUND: Needle stick injuries (NSIs) are one of the most common health hazards facing health care workers (HCWs) across the globe. Needles with safety engineered devices (SEDs) have been developed to minimize the risk of exposure to blood-borne infections such as Hepatitis B virus (HBV), Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) associated with NSIs. AIM: To assess the effect of the introduction of SEDs in preventing NSIs among HCWs in the Jeroen Bosch Hospital (JBH), the Netherlands...
May 5, 2018: Journal of Hospital Infection
Adrien Lemaignen, Laurence Armand-Lefevre, Gabriel Birgand, Guillaume Mabileau, Isabelle Lolom, Walid Ghodbane, Pierre Dilly Marie, Patrick Nataf, Jean-Christophe Lucet
INTRODUCTION: Sternal wound infection (SWI) after cardiac surgery is a severe complication. Among preventive measures, pre-operative decolonisation of nasal carriage of Staphylococcus aureus has recently been shown to be beneficial. In this quasi-experimental study, we assessed the effect of decolonisation on the incidence of S. aureus-associated SWI during 19-year prospective surveillance. METHODS: We analysed by segmented negative binomial regression the change over time of the incidence of S...
May 4, 2018: Journal of Hospital Infection
Michael A Borg, Andre Brincat
No abstract text is available yet for this article.
May 4, 2018: Journal of Hospital Infection
Denise B Assis, Geraldine Madalosso, Maria Clara Padoveze, Renata D Lobo, Maura S Oliveira, Ícaro Boszczowski, Julio M Singer, Anna S Levin
BACKGROUND: There is a scarcity of studies exploring implementation strategies to central line-associated bloodstream infections (CLABSI) in low or middle income countries. AIM: to implement tailored interventions to reduce CLABSI rates in adult intensive care units (ICU). METHODS: The implementation strategy of the State Health Department was performed in São Paulo State, Brazil over two cycles. Cycle 1 (56 hospitals) was exploratory and Cycle 2 (77 hospitals) was designed to confirm the hypothesis generated by the first cycle, with 3 phases each (pre-intervention, intervention, post-intervention)...
May 3, 2018: Journal of Hospital Infection
Jonathan C Cho, Rebecca L Dunn, Frank Yu, Grace A Loredo, Bradley Brazill
INTRODUCTION: Antimicrobial stewardship programs (ASPs) serve as the primary method to prevent and manage the development of antimicrobial resistance. Rural settings may lack the recommended personnel and resources needed to provide antimicrobial stewardship services. METHODS: An electronic survey was distributed via e-mail to pharmacy directors or antimicrobial stewardship programme directors of licensed hospitals within the Public Health Region 4/5N of East Texas...
May 3, 2018: Journal of Hospital Infection
Appiah-Korang Labi, Noah Obeng-Nkrumah, Enid Owusu, Stephanie Bjerrum, Antoinette Bediako-Bowan, Gifty Sunkwa-Mills, Christiana Akuffo, Ama Pokua Fenny, Japheth Awuletey Opintan, Christabel Enweronu-Laryea, Samuel Debrah, Nelson Damale, Cynthia Bannerman, Mercy Jemima Newman
BACKGROUND: There is a paucity of data describing hospital acquired infections (HAIs) in Africa. OBJECTIVE: To describe the prevalence and distribution of HAIs in acute care hospitals in Ghana. METHODS: Between September and December 2016, point prevalence surveys were conducted in participating hospitals using protocols of the European Centre for Disease Prevention and Control. We reviewed medical records of eligible inpatients at or before 8am on the day of survey to identify HAIs present at the time of survey...
May 3, 2018: Journal of Hospital Infection
Stefanie Gemein, Bernhard Meyer, Jürgen Gebel, Christine Roques, Katrin Steinhauer
No abstract text is available yet for this article.
May 2, 2018: Journal of Hospital Infection
T Waldow, T Ghazy, T Madej, K Plötze, C Birkner, A Mahlmann, K Matschke
BACKGROUND: Reducing post-sternotomy mediastinitis (PSM) requires incorporating multiple methods. However, the independent effects of these measures are not well studied. AIM: To evaluate the independent effect of preoperative disinfection using isopropyl alcohol (IPA)-chlorhexidine gluconate (CHG) and the topical application of a retrosternal gentamicin collagen sponge at wound closure on reducing PSM. METHODS: From October 2012 to August 2014, 2340 patients were included in this prospective, controlled registry...
April 25, 2018: Journal of Hospital Infection
Lynne V McFarland, Noam Ship, Julie Auclair, Mathieu Millette
Clostridium difficile infections (CDI) have become the leading cause of healthcare-associated infections and causes outbreaks around the world. Although various new innovative treatments have been developed, preventive strategies using multi-faceted infection control programmes have not been as successful in reducing CDI rates. The major risk factor for CDI is the disruption of the normally protective gastrointestinal microbiota, typically by antibiotic use. Supplementation with specific probiotics has been found to be effective in preventing various negative outcomes, including antibiotic-associated diarrhoea and CDI...
April 24, 2018: Journal of Hospital Infection
Gemma Winzor, Abid Hussain
No abstract text is available yet for this article.
April 23, 2018: Journal of Hospital Infection
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