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Journal of Muscle Research and Cell Motility

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https://www.readbyqxmd.com/read/30051360/cold-shock-protein-rbm3-attenuates-atrophy-and-induces-hypertrophy-in-skeletal-muscle
#1
Douglas W Van Pelt, Amy L Confides, Andrew R Judge, Peter W Vanderklish, Esther E Dupont-Versteegden
RNA-binding motif protein 3 (RBM3), a stress-inducible RNA-binding protein that increases protein synthesis and confers cell protection in multiple cell types, has been identified as a possible regulator of skeletal muscle mass. Therefore, the primary aim of this study was to examine the impact of elevated RBM3 on skeletal muscle hypertrophy and resistance to atrophy. Plasmid-mediated overexpression of RBM3 in vitro and in vivo was used to assess the role of RBM3 in muscle. C2 C12 myotubes overexpressing RBM3 were approximately 1...
July 26, 2018: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29948664/physiological-and-biochemical-characteristics-of-skeletal-muscles-in-sedentary-and-active-rats
#2
Hongyang Xu, Xiaoyu Ren, Graham D Lamb, Robyn M Murphy
Laboratory rats are sedentary if housed in conditions where activity is limited. Changes in muscle characteristics with chronic inactivity were investigated by comparing sedentary rats with rats undertaking voluntary wheel running for either 6 or 12 weeks. EDL (type II fibers) and soleus (SOL) muscles (predominantly type I fibers) were examined. When measured within 1-2 h post-running, calcium sensitivity of the contractile apparatus was increased, but only in type II fibers. This increase disappeared when fibers were treated with DTT, indicative of oxidative regulation of the contractile apparatus, and was absent in fibers from rats that had ceased running 24 h prior to experiments...
June 15, 2018: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29948663/bgp-15-improves-contractile-function-of-regenerating-soleus-muscle
#3
Tábata L Nascimento, Meiricris T Silva, Elen H Miyabara
This study investigated the effect of the heat shock protein inducer O-[3-piperidino-2-hydroxy-1-propyl]-nicotinic amidoxime (BGP-15) on the morphology and contractile function of regenerating soleus muscles from mice. Cryolesioned soleus muscles from young mice treated daily with BGP-15 (15 mg/Kg) were evaluated on post-cryolesion day 10. At this time point, there was a significant decrease in the cross-sectional area of regenerating myofibers, maximal force, specific tetanic force, and fatigue resistance of regenerating soleus muscles...
June 11, 2018: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29869011/the-expression-of-aquaporin-4-is-regulated-based-on-innervation-in-skeletal-muscles
#4
Minenori Ishido, Tomohiro Nakamura
Aquaporin-4 (AQP4) is a selective water channel, which expresses on the plasma membrane of myofibers and regulates the osmotic pressure, energy metabolism and morphological changes in myofibers by modulating water transport across sarcolemma in skeletal muscles. Although the physiological roles of AQP4 have been gradually clarified in skeletal muscles, the regulatory mechanisms of AQP4 expression have been poorly understood in skeletal muscles. Recently, it was reported that the expression of AQP4 decreased in atrophied skeletal muscles following sciatic nerve transection, but not tail-suspension...
June 4, 2018: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29218609/abstracts-of-emc2017
#5
(no author information available yet)
No abstract text is available yet for this article.
December 7, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29582353/development-of-apical-hypertrophic-cardiomyopathy-with-age-in-a-transgenic-mouse-model-carrying-the-cardiac-actin-e99k-mutation
#6
Li Wang, Fan Bai, Qing Zhang, Weihua Song, Andrew Messer, Masataka Kawai
In both humans and mice, the Glu-99-Lys (E99K) mutation in the cardiac actin gene (ACTC) results in little understood apical hypertrophic cardiomyopathy (AHCM). To determine how cross-bridge kinetics change with AHCM development, we applied sinusoidal length perturbations to skinned papillary muscle fibres from 2- and 5-month old E99K transgenic (Tg) and non-transgenic (NTg) mice, and studied tension and its transients. These age groups were chosen because our preliminary studies indicated that AHCM develops with age...
December 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29546606/hans-christoph-l%C3%A3-ttgau-20-july-1926-5-november-2017
#7
D George Stephenson, David J Miller
No abstract text is available yet for this article.
December 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29185184/changes-in-contractile-and-metabolic-parameters-of-skeletal-muscle-as-rats-age-from-3-to-12-months
#8
Hongyang Xu, Graham D Lamb, Robyn M Murphy
Laboratory rats are considered mature at 3 months despite that musculoskeletal growth is still occurring. Changes in muscle physiological and biochemical characteristics during development from 3 months, however, are not well understood. Whole muscles and single skinned fibres from fast-twitch extensor digitorum longus (EDL) and predominantly slow-twitch soleus (SOL) muscles were examined from male Sprague-Dawley rats (3, 6, 9, 12 months). Ca2+ sensitivity of contractile apparatus decreased with age in both fast- (~ 0...
December 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28986699/anisotropic-mechanosensitive-pathways-in-the-diaphragm-and-their-implications-in-muscular-dystrophies
#9
REVIEW
Patricia S Pardo, Michael A Lopez, Junaith S Mohamed, Aladin M Boriek
The diaphragm is the "respiratory pump;" the muscle that generates pressure to allow ventilation. Diaphragm muscles play a vital function and thus are subjected to continuous mechanical loading. One of its peculiarities is the ability to generate distinct mechanical and biochemical responses depending on the direction through which the mechanical forces applied to it. Contractile forces originated from its contractile components are transmitted to other structural components of its muscle fibers and the surrounding connective tissue...
December 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29190010/are-mechanically-sensitive-regulators-involved-in-the-function-and-patho-physiology-of-cerebral-palsy-related-contractures
#10
Jessica Pingel, Frank Suhr
Skeletal muscle tissue is mechanosensitive, as it is able to sense mechanical impacts and to translate these into biochemical signals making the tissue adapt. Among its mechanosensitive nature, skeletal muscle tissue is the largest metabolic organ of the human body. Disturbances in skeletal muscle mechanosensing and metabolism cause and contribute to many diseases, i.e. muscular dystrophies/myopathies, cardiovascular diseases, COPD or diabetes mellitus type 2. A less commonly focused muscle-related disorder is clinically known as muscle contractures that derive from cerebral palsy (CP) conditions in young and adults...
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29170862/editorial-on-emc-2017-special-issue
#11
EDITORIAL
Martina Krüger
No abstract text is available yet for this article.
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29147874/obituary-bernhard-brenner
#12
Joseph M Chalovich, Theresia Kraft, Leepo C Yu
No abstract text is available yet for this article.
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29119312/when-signalling-goes-wrong-pathogenic-variants-in-structural-and-signalling-proteins-causing-cardiomyopathies
#13
Mehroz Ehsan, He Jiang, Kate L Thomson, Katja Gehmlich
Cardiomyopathies are a diverse group of cardiac disorders with distinct phenotypes, depending on the proteins and pathways affected. A substantial proportion of cardiomyopathies are inherited and those will be the focus of this review article. With the wide application of high-throughput sequencing in the practice of clinical genetics, the roles of novel genes in cardiomyopathies are recognised. Here, we focus on a subgroup of cardiomyopathy genes [TTN, FHL1, CSRP3, FLNC and PLN, coding for Titin, Four and a Half LIM domain 1, Muscle LIM Protein, Filamin C and Phospholamban, respectively], which, despite their diverse biological functions, all have important signalling functions in the heart, suggesting that disturbances in signalling networks can contribute to cardiomyopathies...
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29101517/intrinsic-myh7-expression-regulation-contributes-to-tissue-level-allelic-imbalance-in-hypertrophic-cardiomyopathy
#14
Judith Montag, Mandy Syring, Julia Rose, Anna-Lena Weber, Pia Ernstberger, Anne-Kathrin Mayer, Edgar Becker, Britta Keyser, Cristobal Dos Remedios, Andreas Perrot, Jolanda van der Velden, Antonio Francino, Francesco Navarro-Lopez, Carolyn Yung Ho, Bernhard Brenner, Theresia Kraft
HCM, the most common inherited cardiac disease, is mainly caused by mutations in sarcomeric genes. More than a third of the patients are heterozygous for mutations in the MYH7 gene encoding for the β-myosin heavy chain. In HCM-patients, expression of the mutant and the wildtype allele can be unequal, thus leading to fractions of mutant and wildtype mRNA and protein which deviate from 1:1. This so-called allelic imbalance was detected in whole tissue samples but also in individual cells. There is evidence that the severity of HCM not only depends on the functional effect of the mutation itself, but also on the fraction of mutant protein in the myocardial tissue...
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28918606/kinetic-coupling-of-phosphate-release-force-generation-and-rate-limiting-steps-in-the-cross-bridge-cycle
#15
Robert Stehle, Chiara Tesi
A basic goal in muscle research is to understand how the cyclic ATPase activity of cross-bridges is converted into mechanical force. A direct approach to study the chemo-mechanical coupling between Pi release and the force-generating step is provided by the kinetics of force response induced by a rapid change in [Pi ]. Classical studies on fibres using caged-Pi discovered that rapid increases in [Pi ] induce fast force decays dependent on final [Pi ] whose kinetics were interpreted to probe a fast force-generating step prior to Pi release...
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28918572/spot-light-on-skeletal-muscles-optogenetic-stimulation-to-understand-and-restore-skeletal-muscle-function
#16
Tobias van Bremen, Thorsten Send, Philipp Sasse, Tobias Bruegmann
Damage of peripheral nerves results in paralysis of skeletal muscle. Currently, the only treatment option to restore proper function is electrical stimulation of the innervating nerve or of the skeletal muscles directly. However this approach has low spatial and temporal precision leading to co-activation of antagonistic muscles and lacks cell-type selectivity resulting in pain or discomfort by stimulation of sensible nerves. In contrast to electrical stimulation, optogenetic methods enable spatially confined and cell-type selective stimulation of cells expressing the light sensitive channel Channelrhodopsin-2 with precise temporal control over the membrane potential...
August 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28905159/are-there-two-different-binding-sites-for-atp-on-the-myosin-head-or-only-one-that-switches-between-two-conformers
#17
Chiara Tesi, Tom Barman, Corinne Lionne
No abstract text is available yet for this article.
April 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28803268/proteomic-profiling-of-the-dystrophin-complex-and-membrane-fraction-from-dystrophic-mdx-muscle-reveals-decreases-in-the-cytolinker-desmoglein-and-increases-in-the-extracellular-matrix-stabilizers-biglycan-and-fibronectin
#18
Sandra Murphy, Heinrich Brinkmeier, Mirjam Krautwald, Michael Henry, Paula Meleady, Kay Ohlendieck
The almost complete loss of the membrane cytoskeletal protein dystrophin and concomitant drastic reduction in dystrophin-associated glycoproteins are the underlying mechanisms of the highly progressive neuromuscular disorder Duchenne muscular dystrophy. In order to identify new potential binding partners of dystrophin or proteins in close proximity to the sarcolemmal dystrophin complex, proteomic profiling of the isolated dystrophin-glycoprotein complex was carried out. Subcellular membrane fractionation and detergent solubilisation, in combination with ion exchange, lectin chromatography and density gradient ultracentrifugation, was performed to isolate a dystrophin complex-enriched fraction...
April 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28733815/structure-of-isolated-z-disks-from-honeybee-flight-muscle
#19
Mara Rusu, Zhongjun Hu, Kenneth A Taylor, John Trinick
The Z-disk is a complex structure comprising some 40 proteins that are involved in the transmission of force developed during muscle contraction and in important signalling pathways that govern muscle homeostasis. In the Z-disk the ends of antiparallel thin filaments from adjacent sarcomeres are crosslinked by α-actinin. The structure of the Z-disk lattice varies greatly throughout the animal kingdom. In vertebrates the thin filaments form a tetragonal lattice, whereas invertebrate flight muscle has a hexagonal lattice...
April 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28707142/myosin-ii-sequences-for-lethocerus-indicus
#20
Lanette Fee, Weili Lin, Feng Qiu, Robert J Edwards
We present the genomic and expressed myosin II sequences from the giant waterbug, Lethocerus indicus. The intron rich gene appears relatively ancient and contains six regions of mutually exclusive exons that are alternatively spliced. Alternatively spliced regions may be involved in the asymmetric myosin dimer structure known as the interacting heads motif, as well as stabilizing the interacting heads motif within the thick filament. A lack of negative charge in the myosin S2 domain may explain why Lethocerus thick filaments display a perpendicular interacting heads motif, rather than one folded back to contact S2, as is seen in other thick filament types such as those from tarantula...
April 2017: Journal of Muscle Research and Cell Motility
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