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Journal of Muscle Research and Cell Motility

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https://www.readbyqxmd.com/read/28224334/the-trpm4-channel-is-functionally-important-for-the-beneficial-cardiac-remodeling-induced-by-endurance-training
#1
Mélanie Gueffier, Justin Zintz, Karen Lambert, Amanda Finan, Franck Aimond, Nourdine Chakouri, Christophe Hédon, Mathieu Granier, Pierre Launay, Jérôme Thireau, Sylvain Richard, Marie Demion
Cardiac hypertrophy (CH) is an adaptive process that exists in two distinct forms and allows the heart to adequately respond to an organism's needs. The first form of CH is physiological, adaptive and reversible. The second is pathological, irreversible and associated with fibrosis and cardiomyocyte death. CH involves multiple molecular mechanisms that are still not completely defined but it is now accepted that physiological CH is associated more with the PI3-K/Akt pathway while the main signaling cascade activated in pathological CH involves the Calcineurin-NFAT pathway...
February 21, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28181043/45th-european-muscle-conference-in-montpellier-france
#2
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28130614/characterization-of-fast-twitch-and-slow-twitch-skeletal-muscles-of-calsequestrin-2-casq2-knock-out-mice-unexpected-adaptive-changes-of-fast-twitch-muscles-only
#3
Giorgia Valle, Barbara Vergani, Roberta Sacchetto, Carlo Reggiani, Edith De Rosa, Lisa Maccatrozzo, Alessandra Nori, Antonello Villa, Pompeo Volpe
This study investigates the functional role of calsequestrin 2 (CASQ2) in both fast-twitch and slow-twitch skeletal muscles by using CASQ2-/- mice; CASQ2 is expressed throughout life in slow-twitch muscles, but only in the developmental and neonatal stages in fast-twitch muscles. CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types. CASQ2-/- mice have ultrastructural changes in fast-twitch muscles only, i.e., formation of pentads and stacks in the sarcoplasmic reticulum...
January 27, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28062939/early-transverse-tubule-development-begins-in-utero-in-the-sheep-heart
#4
Michelle L Munro, Christian Soeller
The ventricular cardiomyocytes of adult mammals contain invaginations of the plasma membrane known as transverse (t)-tubules. These regular structures are essential for the synchronisation of excitation-contraction (EC) coupling throughout the cell, which is a vital process for cardiac function. T-tubules form a close association with the sarcoplasmic reticulum (SR) to form junctions, where several key proteins involved in EC coupling are localised, including the SR calcium release channels-the ryanodine receptors (RyR)...
January 6, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27975185/l71f-mutation-in-rat-cardiac-troponin-t-augments-crossbridge-recruitment-and-detachment-dynamics-against-%C3%AE-myosin-heavy-chain-but-not-against-%C3%AE-myosin-heavy-chain
#5
Sherif M Reda, Sampath K Gollapudi, Murali Chandra
The N-terminal extension of human cardiac troponin T (TnT), which modulates myofilament Ca(2+) sensitivity, contains several hypertrophic cardiomyopathy (HCM)-causing mutations including S69F. However, the functional consequence of S69F mutation is unknown. The human analog of S69F in rat TnT is L71F (TnTL71F). Because the functional consequences due to structural changes in the N-terminal extension are influenced by the type of myosin heavy chain (MHC) isoform, we hypothesized that the TnTL71F-mediated effect would be differently modulated by α- and β-MHC isoforms...
December 14, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27942960/comparison-of-elementary-steps-of-the-cross-bridge-cycle-in-rat-papillary-muscle-fibers-expressing-%C3%AE-and-%C3%AE-myosin-heavy-chain-with-sinusoidal-analysis
#6
Masataka Kawai, Tarek S Karam, John Jeshurun Michael, Li Wang, Murali Chandra
In mammalian ventricles, two myosin heavy chain (MHC) isoforms have been identified. Small animals express α-MHC, whereas large animals express β-MHC, which contribute to a large difference in the heart rate. Sprague-Dawley rats possessing ~99% α-MHC were treated with propylthiouracil to result in 100% β-MHC. Papillary muscles were skinned, dissected into small fibers, and used for experiments. To understand the functional difference between α-MHC and β-MHC, skinned-fibers were activated under the intracellular ionic conditions: 5 mM MgATP, 1 mM Mg(2+), 8 mM Pi, 200 mM ionic strength, pH 7...
December 10, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27864649/cardioprotective-effects-of-omega-3-fatty-acids-origin-of-the-variability
#7
Jérôme Roy, Jean-Yves Le Guennec
Since 40 years, it is known that omega-3 poly-unsaturated fatty acids (ω3 PUFAs) have cardioprotective effects. These include antiarrhythmic effects, improvements of autonomic function, endothelial function, platelet anti-aggregation and inflammatory properties, lowering blood pressure, plaque stabilization and reduced atherosclerosis. However, recently, conflicting results regarding the health benefits of ω3 PUFAs from seafood or ω3 PUFAs supplements have emerged. The aim of this review is to examine recent literature regarding health aspects of ω3 PUFAs intake from fish or supplements, and to discuss different arguments/reasons supporting these conflicting findings...
November 18, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27864648/actomyosin-based-contraction-one-mechanokinetic-model-from-single-molecules-to-muscle
#8
Alf Månsson
Bridging the gaps between experimental systems on different hierarchical scales is needed to overcome remaining challenges in the understanding of muscle contraction. Here, a mathematical model with well-characterized structural and biochemical actomyosin states is developed to that end. We hypothesize that this model accounts for generation of force and motion from single motor molecules to the large ensembles of muscle. In partial support of this idea, a wide range of contractile phenomena are reproduced without the need to invoke cooperative interactions or ad hoc states/transitions...
November 18, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27430739/wilhelm-hasselbach-a-personal-tribute
#9
Johann Caspar Rüegg
Wilhelm Hasselbach (1921-2015) is best known for his major contribution to the discovery and molecular elucidation of an ATP-driven active ion transport across a biological membrane. He had discovered SERCA, the calcium pump of the sarcoplasmic reticulum (Hasselbach and Makinose in Biochem Z 333:518-528, 1961; Biochem Z 339:94-111, 1963).
October 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27590123/differential-effects-of-contractile-potentiators-on-action-potential-induced-ca-2-transients-of-frog-and-mouse-skeletal-muscle-fibres
#10
Caputo Carlo, Bolaños Pura, Ramos Magaly, DiFranco Marino
Muscle fibres, isolated from frog tibialis anterior and mouse flexor digitorum brevis (FDB) were loaded with the fast dye MagFluo-4 to study the effects of potentiators caffeine, nitrate, Zn(2+) and perchlorate on Ca(2+) transients elicited by single action potentials. Overall, the potentiators doubled the transients amplitude and prolonged by about 1.5-fold their decay time. In contrast, as shown here for the first time, nitrate and Zn(2+), but not caffeine, activated a late, secondary component of the transient rising phase of frog but not mouse, fibres...
September 2, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27572873/is-muscle-powered-by-springs-or-motors
#11
Pasquale Bianco, Massimo Reconditi, Gabriella Piazzesi, Vincenzo Lombardi
No abstract text is available yet for this article.
August 29, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27472930/degenerative-and-regenerative-features-of-myofibers-differ-among-skeletal-muscles-in-a-murine-model-of-muscular-dystrophy
#12
Teppei Ikeda, Osamu Ichii, Saori Otsuka-Kanazawa, Teppei Nakamura, Yaser Hosny Ali Elewa, Yasuhiro Kon
Skeletal muscle myofibers constantly undergo degeneration and regeneration. Histopathological features of 6 skeletal muscles (cranial tibial [CT], gastrocnemius, quadriceps femoris, triceps brachii [TB], lumbar longissimus muscles, and costal part of the diaphragm [CPD]) were compared using C57BL/10ScSn-Dmd (mdx) (mdx) mice, a model for muscular dystrophy versus control, C57BL/10 mice. Body weight and skeletal muscle mass were lower in mdx mice than the control at 4 weeks of age; these results were similar at 6-30 weeks...
July 29, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27376658/investigating-the-effects-of-tropomyosin-mutations-on-its-flexibility-and-interactions-with-filamentous-actin-using-molecular-dynamics-simulation
#13
Wenjun Zheng, Sarah E Hitchcock-DeGregori, Bipasha Barua
Tropomyosin (Tpm) is a two-chained α-helical coiled-coil protein that binds to filamentous actin (F-actin), and regulates its interactions with myosin by occupying three average positions on F-actin (blocked, closed, and open). Mutations in the Tpm are linked to heart diseases including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). To elucidate the molecular mechanisms of Tpm mutations (including DCM mutation E54K, HCM mutations E62Q, A63V, K70T, V95A, D175N, E180G, L185R, E192K, and a designed synthetic mutation D137L) in terms of their effects on Tpm flexibility and its interactions with F-actin, we conducted extensive molecular dynamics simulations for the wild-type and mutant Tpm in complex with F-actin (total simulation time 160 ns per mutant)...
July 4, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27344568/excitation-contraction-uncoupling-by-high-intracellular-ca-2-in-frog-skeletal-muscle-a-voltage-clamp-study
#14
J Fernando Olivera, Gonzalo Pizarro
Raising the intracellular [Ca(2+)] ([Ca(2+)]i) was previously found to produce uncoupling between the electrical depolarization of the transverse tubules and contraction in skinned muscle fibers. Here we study the effect of elevated [Ca(2+)]i in voltage clamped cut fibers of frog skeletal muscle to establish how the charge movement, a measure of the activation of the dihydropyridine receptors (DHPR)-voltage sensors, and Ca(2+) release, a consequence of the opening of the ryanodine receptor (RyR)-release channels, were affected...
June 25, 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27460929/muscle-fiber-types-composition-and-type-identified-endplate-morphology-of-forepaw-intrinsic-muscles-in-the-rat
#15
Feng Pan, Jing-Yi Mi, Yan Zhang, Xiao-Yun Pan, Yong-Jun Rui
The failure to accept reinnervation is considered to be one of the reasons for the poor motor functional recovery of intrinsic hand muscles (IHMs) after nerve injury. Rat could be a suitable model to be used in simulating motor function recovery of the IHMs after nerve injury as to the similarities in function and anatomy of the muscles between human and rat. However, few studies have reported the muscle fiber types composition and endplate morphologic characteristics of intrinsic forepaw muscles (IFMs) in the rat...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27443559/exome-sequencing-identifies-variants-in-two-genes-encoding-the-lim-proteins-nrap-and-fhl1-in-an-italian-patient-with-bag3-myofibrillar-myopathy
#16
Francesca D'Avila, Mirella Meregalli, Sara Lupoli, Matteo Barcella, Alessandro Orro, Francesca De Santis, Clementina Sitzia, Andrea Farini, Pasqualina D'Ursi, Silvia Erratico, Riccardo Cristofani, Luciano Milanesi, Daniele Braga, Daniele Cusi, Angelo Poletti, Cristina Barlassina, Yvan Torrente
Myofibrillar myopathies (MFMs) are genetically heterogeneous dystrophies characterized by the disintegration of Z-disks and myofibrils and are associated with mutations in genes encoding Z-disk or Z-disk-related proteins. The c.626 C > T (p.P209L) mutation in the BAG3 gene has been described as causative of a subtype of MFM. We report a sporadic case of a 26-year-old Italian woman, affected by MFM with axonal neuropathy, cardiomyopathy, rigid spine, who carries the c.626 C > T mutation in the BAG3 gene...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27411801/interplay-between-the-effects-of-a-protein-kinase-c-phosphomimic-t204e-and-a-dilated-cardiomyopathy-mutation-k211%C3%AE-or-r206w-in-rat-cardiac-troponin-t-blunts-the-magnitude-of-muscle-length-mediated-crossbridge-recruitment-against-the-%C3%AE-myosin-heavy-chain-background
#17
John Jeshurun Michael, Sampath K Gollapudi, Murali Chandra
Failing hearts of dilated cardiomyopathy (DCM)-patients reveal systolic dysfunction and upregulation of several Protein Kinase C (PKC) isoforms. Recently, we demonstrated that the functional effects of T204E, a PKC phosphomimic of cardiac troponin T (TnT), were differently modulated by α- and β-myosin heavy chain (MHC) isoforms. Therefore, we hypothesized that the interplay between the effects of T204E and a DCM-linked mutation (K211Δ or R206W) in TnT would modulate contractile parameters linked-to systolic function in an MHC-dependent manner...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27334505/cloning-molecular-characterization-and-expression-analysis-of-the-unc45-myosin-chaperone-b-unc45b-gene-of-grass-carp-ctenopharyngodon-idellus
#18
Jing Hu, Ting Guo, Wen-Qian Pan, Tian Gan, Jing Wei, Jun-Peng Wang, Xiang-Jun Leng, Xiao-Qin Li
Unc45 myosin chaperone b(unc45b)gene is a molecular chaperone that mediates the folding, assembly and accumulation of thick-filament myosin in the formation of sarcomere, which plays an important role in the development of striated muscle and the stability of sarcomere. In this study, the complete cDNA sequence of unc45b gene of grass carp was obtained by rapid amplification of cDNA ends (RACE), and the characteristics of the unc45b protein predicted from gene sequence was analyzed by bioinformatics methods...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27329158/sarcoplasmic-reticulum-is-an-intermediary-of-mitochondrial-and-myofibrillar-growth-at-the-intercalated-disc
#19
Pauline M Bennett, Elisabeth Ehler, Amanda J Wilson
In cardiomyocytes columns of intermyofibrillar mitochondria run up to the intercalated disc (ID); half are collinear with those in the neighbouring cell, suggesting coordinated addition of sarcomeres and mitochondria both within and between cells during cardiomyocyte growth. Recent evidence for an association between sarcoplasmic reticulum (SR) and mitochondria indicates that the SR may be an intermediary in this coordinated behaviour. For this reason we have investigated the arrangement of SR and t tubules with respect to mitochondria and myofibrils, particularly at the ID...
June 2016: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/27090236/comprehensive-analysis-of-tropomyosin-isoforms-in-skeletal-muscles-by-top-down-proteomics
#20
Yutong Jin, Ying Peng, Ziqing Lin, Yi-Chen Chen, Liming Wei, Timothy A Hacker, Lars Larsson, Ying Ge
Mammalian skeletal muscles are heterogeneous in nature and are capable of performing various functions. Tropomyosin (Tpm) is a major component of the thin filament in skeletal muscles and plays an important role in controlling muscle contraction and relaxation. Tpm is known to consist of multiple isoforms resulting from different encoding genes and alternative splicing, along with post-translational modifications. However, a systematic characterization of Tpm isoforms in skeletal muscles is still lacking. Therefore, we employed top-down mass spectrometry (MS) to identify and characterize Tpm isoforms present in different skeletal muscles from multiple species, including swine, rat, and human...
April 2016: Journal of Muscle Research and Cell Motility
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