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International Endodontic Journal

F Benetti, J E Gomes-Filho, L L Ferreira, G Sivieri-Araújo, E Ervolino, A L F Briso, L T A Cintra
AIM: To evaluate lymphocyte-like cell activation (CD5-positive cells) and the expression of interleukin (IL)-6 and IL-17 in the pulp after dental bleaching with two concentrations of hydrogen peroxide (H2 O2 ). METHODOLOGY: The right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20% H2 O2 (BLUE group, 1 application of 50 min), 35% H2 O2 (MAXX group, 3 applications of 15 min), or placebo gel (Control). After 2 and 30 days, the rats were killed (n=10), and the jaws were processed for histological and immunohistochemistry analysis of the pulp tissue...
January 20, 2018: International Endodontic Journal
T Luo, J Liu, Y Sun, Y Shen, L Zou
AIM: To evaluate the cytocompatibility of Biodentine and iRoot FS with human periodontal ligament cells (hPDLCs). METHODOLOGY: hPDLCs were characterized by flow cytometry and immunocytochemical analysis. hPDLC adhesion was assessed by scanning electron microscopy at day 3; proliferation by live/dead assay at day 1, 3 and 7; and osteogenic differentiation by alkaline phosphatase (ALP) activity staining, ALP quantification analysis and qRT-PCR at day 7 and 14. Data were analysed with ANOVA and independent sample t-tests with SPSS 21...
January 19, 2018: International Endodontic Journal
C Kruse, R Spin-Neto, A Wenzel, M Vaeth, L-L Kirkevang
AIM: To evaluate how additional information from Cone Beam CT (CBCT) impactson periapical assessment and treatment planning based on clinical examination and periapical radiographs (PR) in cases followed-up five to eleven years after surgical endodontic retreatment (SER). METHODOLOGY: Patients receiving SER during 2004-2010 were re-invited for follow-up examination including clinical examination, PR, and CBCT. In total 108 patients (119 teeth) were re-invited, 74 patients (83 teeth) accepted to participate...
January 18, 2018: International Endodontic Journal
A A Al Masan, P M H Dummer, D J J Farnell, M E Vianna
AIM: To evaluate the views of final-year dental surgery (BDS; G1) students at Cardiff University and general dental practitioners (GDPs; G2) within the city of Cardiff, Wales on antibiotic prescribing for endodontic conditions, and investigate the potential differences between the two groups. METHODS: A cross-sectional online questionnaire-based survey of 12 qualitative and quantitative questions was distributed to 76 final-year BDS Cardiff University students and 55 dental practices within Cardiff, UK...
January 10, 2018: International Endodontic Journal
A Jakovljevic, M Andric, N Nikolic, V Coric, S Krezovic, J Carkic, A Knezevic, K Beljic-Ivanovic, M Plješa-Ercegovac, M Miletić, I Soldatovic, T Radosavljevic, T Jovanovic, T Simic, V Ivanovic, J Milasin
AIM: To investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers (8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)) and bone resorption regulators (receptor activator of nuclear factor (NF-κB) ligand (RANKL) and osteoprotegerin (OPG)) compared to EBV negative periapical lesions and healthy pulp tissues. METHODOLOGY: The experimental group consisted of 30 EBV positive and 30 EBV negative periapical lesions collected in conjunction with apicoectomy...
January 9, 2018: International Endodontic Journal
L M S Castro-Raucci, L N Teixeira, A F S Barbosa, R R Fernandes, W Raucci-Neto, M Jacobovitz, I R Oliveira, P T de Oliveira
AIM: To evaluate the effects of 2.8% or 10% calcium chloride (CaCl2 ) in calcium aluminate cement (CAC) with either bismuth oxide (Bi2 O3 ) or zinc oxide (ZnO) as radiopacifiers on the progression of osteogenic cell cultures. METHODOLOGY: Rat calvaria-derived cells were grown on Thermanox® coverslips for 24 h and exposed to samples of 1) CACb: with 2.8% CaCl2 and 25% Bi2 O3 ; 2) CACb+: with 10% CaCl2 and 25% Bi2 O3 ; 3) CACz: with 2.8% CaCl2 and 25% ZnO; or 4) CACz+: with 10% CaCl2 and 25% ZnO, placed on inserts...
December 11, 2017: International Endodontic Journal
M Matoug-Elwerfelli, M S Duggal, H Nazzal, F Esteves, E Raïf
AIM: To investigate the feasibility of decellularising the entire dental pulp using a mild treatment protocol to develop a decellularised biological extracellular matrix scaffold for use in regenerative endodontic procedures. METHODOLOGY: Decellularised human dental pulps were assessed using histological and immunohistochemical methods, scanning electron microscope and DNA quantification assay. Cytotoxicity assays to determine decellularised scaffold biocompatibility were also performed...
December 1, 2017: International Endodontic Journal
S A Mohmmed, M E Vianna, M R Penny, S T Hilton, N J Mordan, J C Knowles
AIM: To investigate in situ Enterococcus faecalis biofilm removal from the lateral canal of a simulated root canal system using passive or active irrigation protocols. METHODOLOGY: Root canal models (n = 43) were manufactured from transparent resin materials using 3D-printing. Each canal was created with an 18 mm length, apical size 30, a .06 taper, and a lateral canal of 3 mm length, 0.3 mm diameter. Biofilms were grown on the lateral canal and apical 3 mm of the main canal for 10 days...
November 27, 2017: International Endodontic Journal
S R Pinheiro, M P Alcade, N Vivacqua-Gomes, C M Bramante, R R Vivan, M A H Duarte, B C Vasconcelos
AIM: To evaluate apical transportation and centring ability during root canal preparation in mesial root canals of mandibular molars associated with ProTaper Gold (PTG), ProDesign S (PDS), Hyflex CM (HCM), Hyflex EDM (HEDM) and ProDesign Logic (PDL). METHOD: Sixty first mandibular molars with two separete canals in the mesial root were selected after root anatomy pairing by microcomputed tomography (microCT). The teeth were randomly divided into 5 groups (n = 24); the root canal volume was calculated to ensure sample homogeneity...
November 27, 2017: International Endodontic Journal
S S Virdee, D W Seymour, D Farnell, G Bhamra, S Bhakta
AIMS: To establish whether if Irrigant Activation Techniques (IAT) result in greater intracanal smear layer and debris removal than Conventional Needle Irrigation (CNI). METHODOLOGY: Six electronic databases were searched to identify scanning-electron-microscopy studies evaluating smear layer and/or debris removal following use of Manual Dynamic Activation (MDA), Passive Ultrasonic Irrigation (PUI), Sonic Irrigation (SI) or Apical Negative Pressure (ANP) IATs in mature permanent teeth...
November 25, 2017: International Endodontic Journal
M P Alcalde, M A H Duarte, C M Bramante, M Tanomaru-Filho, B C Vasconcelos, M V R Só, R R Vivan
AIM: To evaluate the torsional properties of pathfinding nickel-titanium (NiTi) rotary instruments manufactured from several NiTi alloys, ProGlider (M-wire), Hyflex GPF (conventional NiTi Wire and controlled memory wire), Logic (conventional NiTi wire and controlled memory wire) and Mtwo (conventional NiTi wire). METHODOLOGY: A total of 56 NiTi instruments from Glidepath rotary systems (n = 8) were used Logic (size 25, .01 taper), Logic CM (size 25, .01 taper), ProGlider (size 16, ...
November 24, 2017: International Endodontic Journal
C M Martins, I O A Queiroz, E Ervolino, L T A Cintra, J E Gomes-Filho
AIM: To investigate whether hypertension affects white and grey mineral trioxide aggregate (MTA Angelus (®) ) mineralization implanted subcutaneously into rats by assaying osteoblastic biomarkers. METHODOLOGY: Polyethylene tubes containing grey MTA Angelus (®) , white MTA Angelus (®) , intermediate restorative material (IRM; positive control), or an empty tube (negative control) were implanted into the dorsal connective tissue of spontaneous hypertensive (n = 12) and Wistar (normotensive; n = 10) rats...
November 16, 2017: International Endodontic Journal
A Zollinger, D Mohn, M Zeltner, M Zehnder
AIM: To assess the stability of NaOCl solutions when combined with a novel product for clinical use, Dual Rinse HEDP, which contains etidronate (1-hydroxyethane 1,1-diphosphonate). METHODOLOGY: Mixtures of NaOCl solutions with Dual Rinse HEDP were prepared so that they initially contained 5.0%, 2.5%, or 1.0% NaOCl, and always 9.0% of dissolved Dual Rinse HEDP powder per total weight. NaOCl solutions alone were used as controls. The stability of these solutions over 8 h was assessed in transparent borosilicate glass bottles at ambient temperature (23°C)...
November 9, 2017: International Endodontic Journal
A R Pérez, F R F Alves, M F Marceliano-Alves, J C Provenzano, L S Gonçalves, A A Neves, J F Siqueira
AIM: To evaluate the effects of progressive apical enlargement on the amount of unprepared root canal surface area and remaining dentine thickness. METHODOLOGY: The root canals of 30 extracted mandibular incisors with Vertucci's type I configuration were instrumented with rotary HyFlex CM instruments (Coltene-Whaledent, Altstätten, Switzerland) up to 4 instruments larger than the first one that bound at the working length (WL). Teeth were scanned in a micro-computed tomography (micro-CT) device before canal preparation and after instrumentation with the 2nd, 3rd and 4th larger instruments...
November 7, 2017: International Endodontic Journal
G Bryce, N MacBeth, K Gulabivala, Y-L Ng
AIM: To evaluate the efficacy of sonic irrigation (EndoActivator(®) ) using various polymer tips and power-settings in a stained collagen ex-vivo model. METHODOLOGY: Fifty human, straight single-rooted extracted teeth were prepared to size 40,.08 taper. The roots were split longitudinally; stained collagen applied to the canal surfaces, photographed and re-assembled. The canals were subjected to syringe without supplementary (Group 1, n = 10), or with supplementary sonic (groups 2-5, n = 10) irrigation...
November 6, 2017: International Endodontic Journal
A Hernández-Caldera, R Vernal, R Paredes, P Veloso-Matta, J Astorga, M Hernández
AIM: To characterize the potential of human periodontal ligament fibroblasts (HPLF) to synthesize CRP and Th-related cytokines in response to IL-6 in periodontal health and apical inflammation. METHODOLOGY: Primary HPLF stimulated with IL-6, soluble(s) IL-6 receptor (R) and controls were assayed for CRP, Th1, Th2, Th17 and Treg-related cytokines by quantitative real time PCR and ELISA, respectively. IL-6R mRNA expression and its soluble protein levels were screened in HPLF cultures, and ex vivo samples of healthy periodontal ligaments (n=5) and apical lesions (n=13)...
November 6, 2017: International Endodontic Journal
L Wei, M Liu, H Xiong, B Peng
AIM: To investigate the effects of the pro-inflammatory and Th17-polarizing mediator IL-17 on HDPFs-mediated IL-23 production and the molecular mechanism involved. METHODOLOGY: Interleukin (IL)-17R expression was determined by semi-quantitative reverse transcriptase-polymerase chain reaction and Western blot in cultured human dental pulp fibroblasts (HDPFs). Quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay were used to determine IL-23 mRNA and protein levels in IL-17-stimulated HDPFs, respectively...
November 6, 2017: International Endodontic Journal
H Aksel, Ş Öztürk, A Serper, K Ulubayram
AIM: To investigate the proliferation and differentiation potential of human dental pulp stem cells (DPSCs) in a three-dimensional culture model (TDM) by incorporation of VEGF and BMP-2. METHODOLOGY: TDM was established using fibrin gel (fg) as a soft tissue matrix and demineralized dentine disc (dd) as a hard tissue matrix. DPSCs and vascular endothelial growth factor (VEGF) were encapsulated in fibrin gel (fg-VEGF) and then inserted into bone morphogenetic protein (BMP-2) coated demineralized dentine discs (dd-BMP-2)...
October 28, 2017: International Endodontic Journal
T Connert, M S Zehnder, M Amato, R Weiger, S Kühl, G Krastl
AIM: To present a novel miniaturized and minimally invasive treatment approach for root canal localization in mandibular incisors with pulp canal calcification and apical periodontitis. SUMMARY: A 51-year-old male patient presented with pain from his mandibular incisors. The patient had a history of severe dental trauma over 30 years ago. Both mandibular central incisors (teeth 31, 41) were tender to percussion and had a yellowish discoloration. They did not respond to thermal and electrical sensitivity tests...
February 2018: International Endodontic Journal
P M H Dummer
No abstract text is available yet for this article.
January 2018: International Endodontic Journal
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