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International Endodontic Journal

J Bi, Y Liu, X M Liu, L M Jiang, X Chen
AIM: To investigate the antibacterial activity of a novel intracanal medicament, iRoot FM, against Porphyromonas endodontalis (P. endodontalis) and its effects on the proliferation and osteo-/odontogenic differentiation of stem cells from apical papilla (SCAP). METHODOLOGY: The agar diffusion test was used to compare the antimicrobial efficacy of iRoot FM with two traditional intracanal medicaments, calcium hydroxide [Ca(OH)2 ] and triple antibiotic paste (TAP)...
March 7, 2018: International Endodontic Journal
Ö I Ulusoy, I G Savur, T Alaçam, B Çelik
AIM: To evaluate the effectiveness of NaOCl, NaOCl-EDTA, and NaOCl+HEBP activated by ultrasonics and XP-endo Finisher on organic tissue removal from simulated internal root resorption cavities. METHODOLOGY: The root canals of 144 single-rooted teeth were instrumented. The teeth were split longitudinally and semicircular cavities were prepared in the canals on each half of the roots. Samples obtained from ground bovine muscle tissue were weighed and adapted into the semicircular cavities...
March 5, 2018: International Endodontic Journal
A C S Marinho, T T To, R P Darveau, B P F A Gomes
AIM: To investigate the influence of auxiliary chemical substances (ACS) and calcium hydroxide [Ca(OH)2 ] dressings on LPS/lipid A detection and its functional ability in activating Toll-like receptor 4 (TLR4). METHODOLOGY: Fusobacterium nucleatum pellets were exposed to antimicrobial agents as following: 1) ACS: 5.25%, 2.5% and 1% sodium hypochlorite solutions (NaOCl), 2% chlorhexidine (CHX) (gel and solution) and 17% ethylenediaminetetraacetic acid (EDTA); 2) Intracanal medicament: Ca(OH)2 paste for various periods (1h, 24h, 7 days, 14 days and 30 days); 3) Combination of substances: a) 2...
March 5, 2018: International Endodontic Journal
H Wu, M He, R Yang, Y Zuo, Z Bian
AIM: To identify the role of astrocyte elevated gene-1 (AEG-1) and the mechanism underlying the inflammatory response in dental pulp cells. METHODOLOGY: AEG-1 expression was detected at different stages of pulpitis in a rat model using immunohistochemistry. RT-qPCR and Western blot were used to assess AEG-1 expression in human dental pulp cells stimulated by lipopolysaccharide (LPS). The LPS-induced expression of inflammatory cytokine genes was quantified by RT-qPCR in cells transfected with AEG-1 or negative control (NC) siRNA...
March 5, 2018: International Endodontic Journal
M Toledano, M Toledano-Osorio, A L Medina-Castillo, M T López-López, F S Aguilera, R Osorio
AIM: To investigate if crystallinity and ultrastructure is modified when cervical dentine is treated with four different nanogels-based solutions for remineralizing purposes. METHODOLOGY: Experimental nanogels based on polymeric nanoparticles (NPs) and zinc, calcium, or doxycycline-loaded NPs were applied on citric acid etched dentine to facilitate the occlusion of tubules and the mineralization of the dentine surface. Dentine surfaces were studied by X-ray diffraction and transmission electron microscopy through selected area diffraction and bright-field imaging...
February 28, 2018: International Endodontic Journal
J Anderson, J Wealleans, J Ray
Computer-aided design (CAD) and computer-aided manufacturing (CAM) technologies can leverage cone beam computed tomography (CBCT) data for production of objects used in surgical and nonsurgical endodontics and in educational settings. The aim of this article is to review all current applications of 3D printing in endodontics and to speculate upon future directions for research and clinical use within the specialty. A literature search of PubMed, Ovid and Scopus was conducted using the following terms: stereolithography, 3D printing, computer aided rapid prototyping, surgical guide, guided endodontic surgery, guided endodontic access, additive manufacturing, rapid prototyping, autotransplantation rapid prototyping, computer aided design (CAD), computer aided manufacturing (CAM)...
February 27, 2018: International Endodontic Journal
H S Topçuoğlu, G Topçuoğlu, Ö Kafdağ, H Arslan
AIM: To compare the cyclic fatigue resistance of R-PILOT and WaveOne Gold Glider files in curved artificial canals. METHODOLOGY: A total of 60 new R-PILOT and WaveOne Gold Glider files were tested in artificial canals with 45° and 60° angles of curvature. Fifteen new files of each brand were tested in both canals. Cyclic fatigue resistance was determined by recording the time to file fracture in the artificial canals. The length of each fractured fragment was also recorded...
February 26, 2018: International Endodontic Journal
S Matsuda, T Memida, N Mizuno, I Ogawa, K Ouhara, M Kajiya, T Fujita, E Sugiyama, H Kurihara
AIM: To report a case of reparative bone-like tissue formation in the tooth of a patient with systemic sclerosis. SUMMARY: A 58-year-old Japanese female patient with systemic sclerosis was referred because of tooth fracture. Cone beam computerized tomography (CBCT) revealed multiple root resorption and the unclear transition from alveolar bone to root profile. A sample from a fractured tooth was analysed histologically. Haematoxylin and eosin-stained sections revealed the irregular replacement of pulp and dentine by bone-like tissue...
February 26, 2018: International Endodontic Journal
P Montero-Miralles, J Martín-González, O Alonso-Ezpeleta, M C Jiménez-Sánchez, E Velasco-Ortega, J J Segura-Egea
Regenerative endodontic procedures (REPs) are biologically based procedures planned to replace damaged tissues, including dentinee and root structures, as well as cells of the pulp-dentine complex. Effective sterilization of the root canal is essential in REPs, and antibiotics have been widely used to disinfect root canals. The aim of this paper was to review the scientific literature on 1) Effectiveness of antibiotics used in REPs against bacteria implicated in endodontic disease; 2) Scientific evidence supporting the use of topical antibiotics in REPs; 3) Clinical implications of the use of antibiotics in REPs and the possible side effects; 4) Effect of antibiotics on dental pulp stem cells; and 5) Ongoing research on the use of antibiotics in REPs...
February 26, 2018: International Endodontic Journal
S J Pulikkotil, V Nagendrababu, S K Veettil, P Jinatongthai, F C Setzer
This systematic review (SR; PROSPERO database: CRD42017075160) and network meta-analysis (NMA) identified the most effective oral premedication for anaesthetic success of inferior alveolar nerve blocks (IANB) in cases of irreversible pulpitis. Medline and Ebscohost databases were searched up until 10/2017. Randomized controlled trials (RCT) studying the effect of oral premedication, alone or in combination, on the success of IANB for cases of irreversible pulpitis, compared to placebo or other oral premedications, were included...
February 26, 2018: International Endodontic Journal
T Özyürek, G Uslu, M Gündoğar, K Yılmaz, N M Grande, G Plotino
AIM: To compare the cyclic fatigue resistance and bending properties of R-Pilot and WaveOne Gold (WOG) Glider files, at intracanal temperature (35°C). METHODOLOGY: Forty R-Pilot and 40 WOG Glider files were subjected to a cyclic fatigue resistance test (n = 20), calculating the time to fracture (TTF) in an artificial stainless steel canal. The length of the fractured file tips (FL) was also measured. The fracture surface of fragments was examined with a scanning electron microscope, and the cross-sectional area of the fractured surfaces was measured...
February 25, 2018: International Endodontic Journal
M Maddalone, M Gagliani, C L Citterio, A Pellegatta, M Del Fabbro
AIM: To evaluate retrospectively the prevalence of vertical root fractures (VRF) in a cohort of patients during apical surgery and the factors possibly associated with VRF. METHODOLOGY: The sample consisted of 944 root filled teeth belonging to 768 patients (49.3% males and 50.7% females; mean age 43.5±11.2 years, range 22-68 years), consecutively referred for endodontic surgery over a six-year period. All patients underwent a clinical assessment of their signs and symptoms...
February 25, 2018: International Endodontic Journal
C Prati, C Pirani, F Zamparini, M R Gatto, M G Gandolfi
AIM: To evaluate the number of healthy and functional root filled teeth of patients included in a recall program for at least 20 years. METHODOLOGY: Teeth were root filled by a single specialist following manual canal instrumentation, lateral/vertical compaction of gutta-percha and restored with glass-ionomer cements and bonding system/composite resin. In a large percentage of teeth a metal-ceramic crown was positioned during follow-up. Patients included in the recall program (n=130) were blindly assessed both clinically and radiographically (every 2 years) to evaluate clinical symptoms and periapical status (PAI)...
February 12, 2018: International Endodontic Journal
M Fu, X Huang, W He, B Hou
AIM: To evaluate the frequency of dentinal microcracks after ultrasonic removal of fractured files from the middle third of root canals using micro-computed tomography (micro-CT). METHODOLOGY: Eighteen bilaterally matched pairs of human mandibular incisors extracted for periodontal reasons were included. The matched pairs of teeth were then divided into a control group and an experimental group, with one member of each pair assigned to each group. In the control group, the canals were instrumented using the ProTaper Next (PTN) system...
February 12, 2018: International Endodontic Journal
K Landt, L Hagstam-Harrison, T Kvist, F Frisk, V S Dawson, L Bjørndal, H Fransson
AIM: To study the demographics of Swedish adults who had received a root filling, followed by extraction during the following 5 to 6 years in comparison to subjects who had undergone a corresponding root filling with an uneventful outcome. METHODOLOGY: The root filled maxillary first molar was chosen as the comparison model. The Swedish Social Insurance Agency provided data on all teeth reported as root filled in Sweden during 2009. A comparison group, equally large as the study group, was constructed by randomly selecting subjects with root filled maxillary first molars which had not subsequently been extracted, i...
February 8, 2018: International Endodontic Journal
W L O da Rosa, E Piva, A F Silva
The discovery that dentine is a reservoir of bioactive molecules that can be recruited on demand has attracted efforts to develop new protocols and materials for vital pulp therapy (VPT). The non-collagenous proteins (NCPs) present in the dentine extracellular matrix (ECM) include growth factors (TGF-β1, BMP-7, FGF-2, IGF-1 and -2, NGF, and GDNF), extracellular matrix molecules (DSP, DPP, BSP, DMP-1, and DSPP), and both anti- and pro-inflammatory chemokines and cytokines (TNF-α, IL-1, IL-6, and IL-10). Molecules such as DSP and DPP are mainly expressed by odontoblasts, and they are cleaved products from dentine sialophosphoprotein (DSPP)...
February 6, 2018: International Endodontic Journal
S Proksch, J Brossart, K Vach, E Hellwig, M J Altenburger, L Karygianni
AIM: To investigate if a combination of mineral trioxide aggregate (MTA) and fluoride compounds affects bone cells. METHODOLOGY: MTA discs (ProRoot® , Dentsply Sirona, Ballaigues, Switzerland) with and without addition of 0.1%, 0.25%, and 0.5% sodium fluoride were characterized for their surface roughness by laser scanning microscopy and for the adhesion of human alveolar osteoblasts by scanning electron microscopy. Using eluates from fluoride-enriched MTA discs, the cell proliferation was measured by monitoring the DNA incorporation of 5-bromo-2'-deoxyuridine...
February 3, 2018: International Endodontic Journal
C T Rodrigues, F B de Andrade, L R S M de Vasconcelos, R Z Midena, T C Pereira, M C Kuga, M A H Duarte, N Bernardineli
AIM: To evaluate the antimicrobial action of an irrigant containing silver nanoparticles in aqueous vehicle (AgNp), sodium hypochlorite and chlorhexidine against Enterococcus faecalis biofilm and infected dentinal tubules. METHODOLOGY: Bovine dentine blocks were used for E. faecalis biofilm development for 21 days and irrigated with 94 ppm AgNp solution, 2.5% NaOCl and 2% Chlorhexidine for 5, 15 and 30 minutes. For infection of dentinal tubules with E. faecalis, dentine specimens from bovine incisors were submitted to a contamination protocol over five days, with 8 centrifugation cycles on every alternate day, and irrigated with the same solutions and time intervals used for the biofilm...
February 3, 2018: International Endodontic Journal
N A Taha, S Z Abdelkhader
AIM: To assess the outcome of full pulpotomy using Biodentine in permanent teeth with carious exposures and symptoms indicative of irreversible pulpitis. METHODOLOGY: Sixty-four permanent molar teeth with symptomatic vital pulps in 52 patients aged 19-69 years were included. Preoperative pulpal and periapical diagnosis was established. After informed consent the tooth was anaesthetized, isolated using rubber dam and disinfected with 5% NaOCl before caries excavation; subsequently the pulp was amputated to the level of the canal orifices...
February 3, 2018: International Endodontic Journal
K Yılmaz, G Uslu, M Gündoğar, T Özyürek, N M Grande, G Plotino
AIM: To compare the cyclic fatigue resistance of the One G, ProGlider, HyFlex EDM and R-Pilot glide path NiTi files at body temperature. METHODOLOGY: Twenty One G (size 14, .03 taper), 20 ProGlider (size 16, .02 taper), 20 HyFlex EDM (size 10, .05 taper) and 20 R-Pilot (size 12.5, .04 taper) instruments were operated in rotation at 300rpm (One G, ProGlider and HyFlex) or in reciprocation (R-Pilot) at 35°C in artificial canals that were manufactured by reproducing the size and taper of the instrument until fracture occurred...
January 31, 2018: International Endodontic Journal
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