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Behavioural Brain Research

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https://www.readbyqxmd.com/read/29146281/nucleus-accumbens-core-lesions-induce-sub-optimal-choice-and-reduce-sensitivity-to-magnitude-and-delay-in-impulsive-choice-tasks
#1
Catherine C Steele, Jennifer R Peterson, Andrew T Marshall, Sarah L Stuebing, Kimberly Kirkpatrick
The nucleus accumbens core (NAc) has long been recognized as an important contributor to the computation of reward value that is critical for impulsive choice behavior. Impulsive choice refers to choosing a smaller-sooner (SS) over a larger-later (LL) reward when the LL is more optimal in terms of the rate of reward delivery. Two experiments examined the role of the NAc in impulsive choice and its component processes of delay and magnitude processing. Experiment 1 delivered an impulsive choice task with manipulations of LL reward magnitude, followed by a reward magnitude discrimination task...
November 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29137946/distinct-environmental-enrichment-protocols-reduce-anxiety-but-differentially-modulate-pain-sensitivity-in-rats
#2
Louise Faggionato Kimura, Vânia Gomes de Moura Mattaraia, Gisele Picolo
Environmental enrichment (EE) can alter anxiety as well as perception of nociceptive stimuli, suggesting a relationship between well-being and analgesia. Considering that, we aimed to evaluate the influence of different EE types on anxiety and peripheral pain sensibility of male Wistar rats. Animals were submitted to two different types of EE: On the first one, animals were housed in standard size cages after weaning and received three different objects, one type per week, on a regular basis (simple EE - sEE)...
November 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29137945/the-effects-of-local-microinjection-of-selective-dopamine-d1-and-d2-receptor-agonists-and-antagonists-into-the-dorsal-raphe-nucleus-on-sleep-and-wakefulness-in-the-rat
#3
Jaime M Monti, Héctor Jantos
The effects of the dopamine (DA) D1 and D2 receptor agonists SKF38393, bromocriptine and quinpirole, respectively, on spontaneous sleep were analyzed in adult rats prepared for chronic sleep recordings. Local administration of the DAergic agonists into the dorsal raphe nucleus (DRN) during the light phase of the light-dark cycle induced a significant reduction of rapid-eye movement sleep (REMS) and the number of REM periods. Additionally, bromocriptine and quinpirole significantly increased wakefulness (W)...
November 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29133197/inhibition-of-leukotriene-b4-synthesis-protects-against-early-brain-injury-possibly-via-reducing-the-neutrophil-generated-inflammatory-response-and-oxidative-stress-after-subarachnoid-hemorrhage-in-rats
#4
Zhen-Nan Ye, Ling-Yun Wu, Jing-Peng Liu, Qiang Chen, Xiang-Sheng Zhang, Yue Lu, Meng-Liang Zhou, Wei Li, Zi-Huan Zhang, Da-Yong Xia, Zong Zhuang, Chun-Hua Hang
Leukotriene B4 (LTB4) is a highly potent neutrophil chemoattractant and neutrophils induces inflammatory response and oxidative stress when they recruit to and infiltrate in the injuried/inflamed site, such as the brain parenchyma after aneurysmal subarachnoid hemorrhage (SAH). This study is to investigate the potential effects of inhibition of LTB4 synthesis on neutrophil recruitment, inflammatory response and oxidative stress, as well as early brain injury (EBI) in rats after SAH. A pre-chiasmatic cistern SAH model of rats was used in this experiment...
November 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29129597/cocaine-and-desipramine-elicit-distinct-striatal-noradrenergic-and-behavioral-responses-in-selectively-bred-obesity-resistant-and-obesity-prone-rats
#5
Peter J Vollbrecht, Kathryn M Nesbitt, Omar S Mabrouk, Aaron M Chadderdon, Emily M Jutkiewicz, Robert T Kennedy, Carrie R Ferrario
Previous studies have demonstrated a role for norepinephrine (NE) in energy regulation and feeding, and basal differences have been observed in hypothalamic NE systems in obesity-prone vs. obesity-resistant rats. Differences in the function of brain reward circuits, including in the nucleus accumbens (NAc), have been shown in obesity-prone vs. obesity-resistant populations, leading many researchers to explore the role of striatal dopamine in obesity. However, alterations in NE transmission also affect NAc mediated behaviors...
November 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29129596/amyloid-toxicity-is-enhanced-after-pharmacological-or-genetic-invalidation-of-the-%C3%AF-1-receptor
#6
Tangui Maurice, Manon Strehaiano, Fanny Duhr, Nathalie Chevallier
The sigma-1 receptor (S1R) is a molecular chaperone which activity modulates several intracellular signals including calcium mobilization at mitochondria-associated endoplasmic reticulum membranes. S1R agonists are potent neuroprotectants against neurodegenerative insults and particularly in rodent models of Alzheimer's disease (AD). We here analyzed whether S1R inactivation modifies vulnerability to amyloid toxicity in AD models. Two strategies were used: (1) amyloid β[25-35] (Aβ25-35) peptide (1, 3, 9nmol) was injected intracerebroventricularly in mice treated repeatedly with the S1R antagonist NE-100 or in S1RKO mice, and (2) WT, APPSweInd, S1RKO, and APPSweInd/S1RKO mice were created and female littermates analyzed at 8 months of age...
November 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29128393/rem-sleep-deprivation-and-dopaminergic-d2-receptors-modulation-increase-recognition-memory-in-an-animal-model-of-parkinson-s-disease
#7
Adriano D S Targa, Ana Carolina D Noseda, Lais S Rodrigues, Mariana F Aurich, Marcelo M S Lima
Cognitive impairment is an important non-motor symptom of Parkinson's disease (PD). The neuronal death in nigrostriatal pathway is the main factor for motor symptoms and recent studies indicate a possible influence in non-motor symptoms as well. The pedunculopontine tegmental nucleus (PPT) and basal ganglia are closely related anatomically and functionally and, since they are affected by neurodegeneration in PD, they might be involved in recognition memory. To investigate this, we promoted an ibotenic acid lesion within the PPT or a rotenone lesion within substantia nigra pars compacta (SNpc) of Wistar rats, followed by 24h of REM sleep deprivation (REMSD)...
November 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29128392/adrenergic-manipulation-inhibits-pavlovian-conditioned-approach-behaviors
#8
Kyle Z Pasquariello, Marina Han, Cagla Unal, Paul J Meyer
Environmental rewards and Pavlovian reward cues can acquire incentive salience, thereby eliciting incentive motivational states and instigate reward-seeking. In rats, the incentive salience of food cues can be measured during a Pavlovian conditioned approach paradigm, in which rats engage in cue-directed approach ("sign-tracking") or approach the food delivery location ("goal-tracking"). While it has been shown that dopamine signaling is necessary for sign-tracking, some studies have suggested that norepinephrine is involved in learning to sign-track as well...
November 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29126932/docosahexaenoic-acid-dha-enhances-the-therapeutic-potential-of-neonatal-neural-stem-cell-transplantation-post-traumatic-brain-injury
#9
Hussein Ghazale, Naify Ramadan, Sara Mantash, Kazem Zibara, Sally El-Sitt, Hala Darwish, Farah Chamaa, Rose Mary Boustany, Stefania Mondello, Wassim Abou-Kheir, Jihane Soueid, Firas Kobeissy
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide with 1.5 million people inflicted yearly. Several neurotherapeutic interventions have been proposed including drug administration as well as cellular therapy involving neural stem cells (NSCs). Among the proposed drugs is docosahexaenoic acid (DHA), a polyunsaturated fatty acid, exhibiting neuroprotective properties. In this study, we utilized an innovative intervention of neonatal NSCs transplantation in combination with DHA injections in order to ameliorate brain damage and promote functional recovery in an experimental model of TBI...
November 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29126931/phytochemical-allylguaiacol-exerts-a-neuroprotective-effect-on-hippocampal-cells-and-ameliorates-scopolamine-induced-memory-impairment-in-mice
#10
Hye-Sun Lim, Bu-Yeo Kim, Yu Jin Kim, Soo-Jin Jeong
Allylguaiacol is a phytochemical occurring in various plants such as cloves, cinnamon, basil, and nutmeg. Pharmacological effects of allylguaiacol include antimicrobial, anti-inflammatory, anticancer, antioxidant, and neuroprotective activity. Although allylguaiacol is considered to have neuroprotective effects, there is no report on its regulatory mechanisms at the molecular level. In the present study, we investigated the mechanisms of allylguaiacol as an antioxidant and neuroprotective agent using hydrogen peroxide (H2O2)-treated HT22 hippocampal cells...
November 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29126930/white-matter-integrity-mediates-decline-in-age-related-inhibitory-control
#11
Peipei Li, Angeliki Tsapanou, Razlighi R Qolamreza, Yunglin Gazes
Previous DTI studies have reported associations between white matter integrity and performance on the Stroop interference task. The current study aimed to add to these studies of inhibitory control by investigating how the differences in age and in white matter integrity relate to Stroop performance, and to examine whether the effect of age on Stroop performance is mediated by white matter integrity. 179 healthy adults from 20 to 80 years old were recruited in the study. DTI data were processed through TRACULA and the mean fractional anisotropy (FA) of 18 major white matter tracts were extracted and used for statistical analysis...
November 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29113874/effect-of-single-doses-of-pindolol-and-d-fenfluramine-on-flumazenil-induced-anxiety-in-panic-disorder-patients
#12
M Bernik, R T Ramos, L A B Hetem, F Graeff
The effects of the 5-HT1A receptor blocker pindolol and the 5-HT releasing and uptake blocking agent d-fenfluramine, both used as indirect serotonin agonists, on flumazenil-induced acute anxiety reactions were studied in panic disorder patients to test the hypothesis that serotonin (5-HT) inhibits neural systems mediating panic attacks. Thirty never treated or drug free PD patients (16 females) aged 22-49 y (mean±SD, 32.9±8) received single doses of d-fenfluramine (n=10; 30mg, p.o.), pindolol (n=10; 5mg, p...
November 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29113873/glucose-metabolic-alterations-in-hippocampus-of-diabetes-mellitus-rats-and-the-regulation-of-aerobic-exercise
#13
Jingjing Li, Beibei Liu, Ming Cai, Xiaojing Lin, Shujie Lou
Diabetes could negatively affect the structures and functions of the brain, especially could cause the hippocampal dysfunction, however, the potential metabolic mechanism is unclear. The aim of this study was to investigate the changes of glucose metabolism in hippocampus of diabetes mellitus rats and the regulation of aerobic exercise, and to analyze the possible mechanisms. A rat model of type 2 diabetes mellitus was established by high-fat diet feeding in combination with STZ intraperitoneal injection, then 4 weeks of aerobic exercise was conducted...
November 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29113872/neuroanatomical-correlates-of-time-perspective-a-voxel-based-morphometry-study
#14
Zhiyi Chen, Yiqun Guo, Tingyong Feng
Previous studies indicated that time perspective can affect many behaviors, such as decisions, risk taking, substance abuse and health behaviors. However, very little is known about the neural substrates of time perspective (TP). To address this question, we characterized different dimensions of TP (including the Past, Present, and Future TP) using standardized Zimbardo Time Perspective Inventory (ZTPI), and quantified the gray matter volume using voxel-based morphometry (VBM) method across two independent samples...
November 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29109055/characterization-of-oromotor-and-limb-motor-dysfunction-in-the-dj1-model-of-parkinson-disease
#15
Katie M Yang, Katherine V Blue, Haleigh M Mulholland, Meghna P Kurup, Cynthia A Kelm-Nelson, Michelle R Ciucci
Parkinson disease (PD) is devastating to sensorimotor function that includes cranial/oromotor and limb motor deficits. However, the onset, progression, and neural correlates of PD-related dysfunctions are poorly understood. To address this gap, we used a genetic rat model of PD, DJ1 -/-, and hypothesized that motor deficits would manifest early in the disease process, be progressive in nature, and be related to pathologies in brainstem structures associated with sensorimotor function. The present study compares homozygous DJ1 -/- male rats to age-matched wild type controls...
November 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29103920/influence-of-the-anteromedial-thalamus-on-social-defeat-associated-contextual-fear-memory
#16
Miguel J Rangel, Marcus Vinicius C Baldo, Newton Sabino Canteras
The ventral part of the anteromedial thalamic nucleus (AMv) is heavily targeted by the dorsal premammillary nucleus (PMd), which is the main hypothalamic site that is responsive to both predator and conspecific aggressor threats. This PMd-AMv pathway is likely involved in modulating memory processing, and previous findings from our group have shown that cytotoxic lesions or pharmacological inactivation of the AMv drastically reduced contextual fear responses to predator-associated environments. In the present study, we investigated the role of the AMv in both unconditioned (i...
November 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29103813/corrigendum-to-trpv1-modulates-morphine-induced-conditioned-place-preference-via-p38-mapk-in-the-nucleus-accumbens-behav-brain-res-334-2017-26-33
#17
Sa-Ik Hong, Thi-Lien Nguyen, Shi-Xun Ma, Hyoung-Chun Kim, Seok-Yong Lee, Choon-Gon Jang
No abstract text is available yet for this article.
November 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29102593/resveratrol-promotes-huc-mscs-engraftment-and-neural-repair-in-a-mouse-model-of-alzheimer-s-disease
#18
Xinxin Wang, Shanshan Ma, Bo Yang, Tuanjie Huang, Nan Meng, Ling Xu, Qu Xing, Yanting Zhang, Kun Zhang, Qinghua Li, Tao Zhang, Junwei Wu, Greta Luyuan Yang, Fangxia Guan, Jian Wang
Mesenchymal stem cell transplantation is a promising therapeutic approach for Alzheimer's disease (AD). However, poor engraftment and limited survival rates are major obstacles for its clinical application. Resveratrol, an activator of silent information regulator 2, homolog 1 (SIRT1), regulates cell destiny and is beneficial for neurodegenerative disorders. The present study is designed to explore whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of AD through SIRT1 signaling...
November 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29102592/negative-transfer-effects-between-reference-memory-and-working-memory-training-in-the-water-maze-in-c57bl-6-mice
#19
Lucas Ezequiel Serrano Sponton, Gonzalo Jose Soria, Sylvain Dubroqua, Philipp Singer, Joram Feldon, Pascual A Gargiulo, Benjamin K Yee
The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first...
November 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29102591/hippocampal-gene-expression-patterns-in-oxytocin-male-knockout-mice-are-related-to-impaired-social-interaction
#20
Virginia Meneghini Lazzari, Josi Maria Zimmermann-Peruzatto, Grasiela Agnes, Roberta Oriques Becker, Ana Carolina de Moura, Silvana Almeida, Renata Padilha Guedes, Marcia Giovenardi
Social interaction between animals is crucial for the survival and life in groups. It is well demonstrated that oxytocin (OT) and vasopressin (AVP) play critical roles in the regulation of social behaviors in mammals, however, other neurotransmitters and hormones are involved in the brain circuitry related to these behaviors. The present study aimed to investigate the gene expression of neurotransmitter receptors in the brain of OT knockout (OTKO) male mice. In this study, we evaluated the expression levels of the OT receptor (Oxtr), AVP receptors 1a and 1b (Avpr1a; Avpr1b), dopamine receptor 2 (Drd2), and the estrogen receptors alpha and beta (Esr1; Esr2) genes in the hippocampus (HPC), olfactory bulb (OB), hypothalamus (HPT) and prefrontal cortex (PFC)...
November 1, 2017: Behavioural Brain Research
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