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Behavioural Brain Research

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https://www.readbyqxmd.com/read/28202411/dopamine-and-dopamine-receptor-d1-associated-with-decreased-social-interaction
#1
Qiang Liu, Jieyun Shi, Rongfei Lin, Tieqiao Wen
Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders...
February 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28202410/atypical-antipsychotic-clozapine-reversed-deficit-on-prepulse-inhibition-of-the-acoustic-startle-reflex-produced-by-microinjection-of-doi-into-the-inferior-colliculus-in-rats
#2
Rodolpho Pereira de Oliveira, Karen Yuriko Nagaishi, Regina Cláudia Barbosa Silva
Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). The hallucinogen 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-hydroxytryptamine(HT)2 receptor agonist disrupted PPI in rats...
February 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28202409/effects-of-bonding-with-parents-and-home-culture-on-intercultural-adaptations-and-the-moderating-role-of-genes
#3
Desiree Y Phua, Michael J Meaney, Chiea Chuen Khor, Ivy Y M Lau, Ying-Yi Hong
In the current age of globalization, living abroad is becoming an increasingly common and highly sought after experience. Sojourners' ability to adjust to a new culture can be affected by their existing attachments, internalized as intrapsychic environment, as well as their biological sensitivity to environment. This sensitivity can be partly attributed to one's genomic endowments. As such, this prospective study sought to examine the differential effects of early experiences with parents and affection for home culture on young adults' ability to adapt to a foreign culture (n=305, students who studied overseas for a semester) - specifically, the difficulties they experience - moderated by genetic susceptibility...
February 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28193523/faah-inhibition-produces-antidepressant-like-efforts-of-mice-to-acute-stress-via-synaptic-long-term-depression
#4
Ying Wang, Xia Zhang
Recent studies have shown that inhibition of fatty acid amide hydrolase (FAAH), the major degradative enzyme of the endocannabinoid N-arachidonoylethanolamine (AEA), produced antidepressant behavioral responses, but its underlying mechanism is not clear. Here we find that a systemic administration of the FAAH inhibitor PF3845 or an intra-CA1 application of AEA elicits an in vivo long-term depression (LTD) at excitatory glutamatergic CA3-CA1 synapses of the hippocampus. The PF3845- and/or AEA-elicited LTD are abolished by the LTD-blocking peptide Tat-GluR2...
February 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28193522/intracerebroventricular-injection-of-beta-amyloid-in-mice-is-associated-with-long-term-cognitive-impairment-in-the-modified-hole-board-test
#5
Sebastian Schmid, Bettina Jungwirth, Verena Gehlert, Manfred Blobner, Gerhard Schneider, Stephan Kratzer, Kristine Kellermann, Gerhard Rammes
BACKGROUND: The intracerebroventricular injection of beta-amyloid (Aβ) in mice allows the investigation of acute effects on cognitive function and cellular pathology. The aim of this investigation was to further characterize the time course of Aβ-induced cognitive and behavioural changes and to detect potential molecular mechanisms. METHODS: Cannulas were implanted in the lateral cerebral ventricle. 14days after surgery the mice were injected with Aβ1-42 or phosphate buffered saline (PBS)...
February 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28189757/the-effects-of-crf-and-urocortins-on-the-preference-for-social-novelty-of-mice
#6
Zsolt Bagosi, András Czébely-Lénárt, Gergely Karasz, Krisztina Csabafi, Miklós Jászberényi, Gyula Telegdy
The aim of the present study was to determine the role of corticotropin-releasing factor (CRF), the urocortins (UCN 1, UCN 2 and UCN 3) and their receptors (CRF1 and CRF2) in the preference for social novelty of mice. Male CFLP mice were administered intracerebroventricularly (ICV) with CRF, UCN 1, UCN 2 or UCN 3 and/or antalarmin or astressin 2B, selective antagonists of CRF1 receptor and CRF2 receptor, respectively. The mice were investigated in a Crawley social interaction test arena consisting of three chambers: an unknown female was set in the first chamber and a known female, with which the male was familiarized previously for 24hours, was set in the third chamber...
February 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28189758/hypersocial-behavior-and-biological-redundancy-in-mice-with-reduced-expression-of-psd95-or-psd93
#7
Daniela Winkler, Fernanda Daher, Liane Wüstefeld, Kurt Hammerschmidt, Giulia Poggi, Anna Seelbach, Dilja Krueger-Burg, Behnam Vafadari, Anja Ronnenberg, Yanling Liu, Leszek Kaczmarek, Oliver M Schlüter, Hannelore Ehrenreich, Ekrem Dere
The postsynaptic density proteins 95 (PSD95) and 93 (PSD93) belong to a family of scaffolding proteins, the membrane-associated guanylate kinases (MAGUKs), which are highly enriched in synapses and responsible for organizing the numerous protein complexes required for synaptic development and plasticity. Genetic studies have associated MAGUKs with diseases like autism and schizophrenia, but knockout mice show severe, complex defects with difficult-to-interpret behavioral abnormalities due to major motor dysfunction which is atypical for psychiatric phenotypes...
February 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28188814/how-people-with-multiple-sclerosis-cope-with-a-sustained-finger-motor-task-a-behavioural-and-fmri-study
#8
Laura Bonzano, Matteo Pardini, Luca Roccatagliata, Giovanni L Mancardi, Marco Bove
Motor and non-motor basal ganglia (BG) circuits can help healthy subjects cope with task-induced central fatigue and re-establish motor performance after deterioration. This work aimed to assess whether patients with multiple sclerosis (MS) were able to recover motor performance after deterioration due to a demanding task and whether BG activity played a role in performance recovery in this population. Fourteen patients with MS performed a finger-tapping sequence with their right hand during three fMRI sessions: at baseline, after a demanding finger motor task (5-min sequence repetition) and after a short rest period...
February 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28185885/behavioral-effects-in-adolescence-and-early-adulthood-in-two-length-models-of-maternal-separation-in-male-rats
#9
María Banqueri, Marta Méndez, Jorge L Arias
Maternal separation (MS) is an extensively used early life stress model. There is some variability in the MS lengths used. Maternal separation leads to emotional and behavioral alterations such as anxiety, despair, or memory problems. We performed MS in Wistar rats with two length models from postnatal day 1 until day 10 and from postnatal day 1 until day 21 during 4hours per day in both groups. We performed a test battery of a wide range of behaviors to measure anxiety, despair, prepulse inhibition, recognition memory, and associative memory both in adolescent and adult subjects...
February 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28174031/the-role-of-emotional-inhibitory-control-in-specific-internet-addiction-an-fmri-study
#10
Julia Dieter, Sabine Hoffmann, Daniela Mier, Iris Reinhard, Martin Beutel, Sabine Vollstädt-Klein, Falk Kiefer, Karl Mann, Tagrid Leménager
BACKGROUND: Addicts to specific internet applications involving communication features showed increased social anxiety, emotional competence deficits and impaired prefrontal-related inhibitory control. The dorsal Anterior Cingulate Cortex (dACC) likely plays an important role in cognitive control and negative affect (such as social exclusion, pain or anxiety). AIM: To assess (social) anxiety-related inhibitory control in specific internet addiction (addicted use of games and social networks) and its relation to altered dACC activation...
February 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28174030/behavioral-characterization-of-the-anterior-injection-model-of-subarachnoid-hemorrhage
#11
S Boettinger, F Kolk, G Broessner, R Helbok, B Pfausler, E Schmutzhard, R Beer, P Lackner
BACKGROUND: The applicability of various neurological scores has not been sufficiently characterized in the anterior injection model of subarachnoid hemorrhage (SAH). Therefore this study was performed to evaluate different behavioral tests for quantifying disease severity. METHODS: Different volumes of autologous blood were injected stereotaxically into the prechiasmatic cistern of mice. Sham controls underwent the same procedure without blood injection. The following seven days after surgery, mice were evaluated for behavioral deficits by the SHIRPA score, beam balance and flex field analyses...
February 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28167338/dissociation-between-dopaminergic-response-and-motor-behavior-following-intrastriatal-but-not-intravenous-transplant-of-bone-marrow-mononuclear-stem-cells-in-a-mouse-model-of-parkinson-s-disease
#12
Caroline Calice da Silva, Bárbara Nunes Azevedo, Denise Cantarelli Machado, Eduardo R Zimmer, Leo Anderson Meira Martins, Jaderson Costa da Costa
Parkinson's disease is characterized by the progressive loss of dopaminergic neurons from the substantia nigra, a process that leads to a dopamine deficiency in the striatum. This deficiency is responsible for the development of motor symptoms, including resting tremor, bradykinesia, rigidity and postural instability. Based on the observation of substantial neuronal death, alternatives to Parkinson's disease treatment have been studied, including cell-based therapies. The present study aimed to assess the therapeutic potential of intravenous and intrastriatal transplant of bone marrow mononuclear cells in a mouse model of Parkinson's disease...
February 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28167337/profiles-of-brain-central-nervous-system-gene-expression-associated-with-ejaculation-behavior-in-male-rats
#13
Xijun Qin, Xiaojun Ma, Jianhui Liang, Dongping Tu, Zuliang Luo, Jie Huang, Changming Mo
The male rat has been used extensively as a model for evaluating the neurophysiology of sexual behavior. However, gene expression in the brain throughout the process of sexual intercourse has yet to be elucidated. In the present study, we created a transcriptomic BodyMap by performing mRNA-Seq on brain samples from pre-copulatory control (CK), fourth intromission (CR4), ejaculation (EJ) and post-ejaculatory interval 1-min (PEI1) Sprague Dawley rats (n=40, all male, each 10). The resulting analysis generated an average of approximately 47 million sequence reads, indicating changes in roughly 21255 genes for each sample...
February 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28167336/trans-generation-enrichment-of-clozapine-responsiveness-trait-in-mice-using-a-subchronic-hypo-glutamatergic-model-of-schizophrenia-a-preliminary-study
#14
Amir Krivoy, Irit Gil-Ad, Igor Tarasenko, Abraham Weizman, Michal Taler
BACKGROUND: Schizophrenia patients who do not respond to clozapine treatment represent the most debilitating type of schizophrenia with unmet needs for novel interventions. To date there is no validated animal model for clozapine-refractory schizophrenia. METHODS: We used poor performance in the social preference (SP) test of C57/BL mice exposed to subchronic phencyclidine (PCP) as a correlate of negative signs of schizophrenia. Subsequently the mice were treated with clozapine and according to their SP they were defined as responding (i...
February 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28163096/paracetamol-effect-of-early-exposure-on-neurotransmission-spatial-memory-and-motor-performance-in-rats
#15
Kamilla Blecharz-Klin, Agnieszka Piechal, Katarzyna Jawna-Zboińska, Justyna Pyrzanowska, Adriana Wawer, Ilona Joniec-Maciejak, Ewa Widy-Tyszkiewicz
In the present study we examined the effect of prenatal and early life paracetamol exposure on neurotransmission and its behavioural manifestation in rat male pups. In order to assess the ability of spatial learning and memory consolidation and the level of physical and exploratory activity we conducted a series of behavioural tests: Staircase Test, Hole Board Test and Water Maze. The concentrations of monoamines, metabolites and amino acids were determined using High Performance Liquid Chromatography in the prefrontal cortex, hippocampus and striatum...
February 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28163097/socioeconomic-disadvantage-neural-responses-to-infant-emotions-and-emotional-availability-among-first-time-new-mothers
#16
Pilyoung Kim, Christian G Capistrano, Andrew Erhart, Rachel Gray-Schiff, Nanxi Xu
During the early postpartum period, mothers exhibit increased amygdala responses to positive infant expressions, which are important for positive mother-infant relationships. Socioeconomic disadvantage is associated with altered amygdala response to emotional stimuli as well as more negative mother-infant relationships. However, little is known about the role of socioeconomic disadvantage in neural responses specifically to infants. Thus, we examined whether socioeconomic disadvantage (indexed by lower income-to-needs ratio) is associated with neural responses to infant emotions and parenting behaviors among new mothers...
February 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28163095/widespread-hyperphosphorylated-tau-in-the-working-memory-circuit-early-after-cortical-impact-injury-of-brain-original-study
#17
Zi-Ai Zhao, Ya-Lei Ning, Ping Li, Nan Yang, Yan Peng, Ren-Ping Xiong, Yan Zhao, Dong Liu, Xu-Jia Zeng, Jiang-Fan Chen, Yuan-Guo Zhou
A series of neurological and psychiatric symptoms occur after traumatic brain injury (TBI), with cognitive dysfunction being one of the most prominent sequela. Given that tau hyperphosphorylation is an important cause of cognitive impairment in patients of Alzheimer's disease, our present study detected the presence of hyperphosphorylated tau (p-tau), mainly at Ser404, in multiple brain regions, including the ipsilateral parietal cortex, contralateral hippocampus and prefrontal cortex, immediately after the injury in a mouse TBI model; these changes lasted for at least 4w...
February 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28161446/drunk-bugs-chronic-vapour-alcohol-exposure-induces-marked-changes-in-the-gut-microbiome-in-mice
#18
Veronica L Peterson, Nicholas J Jury, Raúl Cabrera-Rubio, Lorraine A Draper, Fiona Crispie, Paul D Cotter, Timothy G Dinan, Andrew Holmes, John F Cryan
The gut microbiota includes a community of bacteria that play an integral part in host health and biological processes. Pronounced and repeated findings have linked gut microbiome to stress, anxiety, and depression. Currently, however, there remains only a limited set of studies focusing on microbiota change in substance abuse, including alcohol use disorder. To date, no studies have investigated the impact of vapour alcohol administration on the gut microbiome. For research on gut microbiota and addiction to proceed, an understanding of how route of drug administration affects gut microbiota must first be established...
February 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28159589/effects-of-lps-induced-immune-activation-prior-to-trauma-exposure-on-ptsd-like-symptoms-in-mice
#19
Jessica Deslauriers, Myrthe van Wijngaarde, Mark A Geyer, Susan Powell, Victoria B Risbrough
The prevalence of posttraumatic stress disorder (PTSD) is high in the armed services, with a rate up to 20%. Multiple studies have associated markers of inflammatory signaling prior to trauma with increased risk of PTSD, suggesting a potential role of the immune system in the development of this psychiatric disorder. One question that arises is if "priming" the immune system before acute trauma alters the stress response and increases enduring effects of trauma. We investigated the time course of inflammatory response to predator stress, a robust stressor that induces enduring PTSD-like behaviors, and the modulation of these effects via prior immune activation with the bacterial endotoxin, lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) agonist...
January 31, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28153394/effects-of-dorsal-hippocampus-catecholamine-depletion-on-paired-associates-learning-and-place-learning-in-rats
#20
Corinna Roschlau, Wolfgang Hauber
Growing evidence suggests that the catecholamine (CA) neurotransmitters dopamine and noradrenaline support hippocampus-mediated learning and memory. However, little is known to date about which forms of hippocampus-mediated spatial learning are modulated by CA signaling in the hippocampus. Therefore, in the current study we examined the effects of 6-hydroxydopamine-induced CA depletion in the dorsal hippocampus on two prominent forms of hippocampus-based spatial learning, that is learning of object-location associations (paired-associates learning) as well as learning and choosing actions based on a representation of the context (place learning)...
January 31, 2017: Behavioural Brain Research
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