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Ultrastructural Pathology

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https://www.readbyqxmd.com/read/28151076/histological-study-on-the-effect-of-aroclor-1254-on-the-epididymis-of-adult-rats-and-the-role-of-l-name-administration
#1
Nehad F Mazen, Rania A Zidan
INTRODUCTION: Aroclor 1254, a commercial polychlorinated biphenyls (PCBs) mixture, was found to elicit various adverse effects on human health. OBJECTIVES: This study aimed to investigate the structural alterations in the epididymis induced by aroclor 1254, and to assess the possible protective role of L-NAME (NG-Nitro-L arginine methyl ester). MATERIALS AND METHODS: Thirty-five adult male albino rats were divided into three groups: control group (15 rats), equally subdivided into subgroup a; negative control group, subgroup b: received intraperitoneal corn oil (5 ml/kg/day), and subgroup c: received intraperitoneal L-NAME (10 mg/kg/day)...
February 2, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28107086/interaction-between-lipid-droplets-and-endoplasmic-reticulum-in-human-atherosclerotic-plaques
#2
Ida Perrotta
Lipid droplets (LDs) are intracellular organelles that are found in nearly all cell types, where they serve fundamental roles in lipid metabolism and energy homeostasis. Traditionally considered as simple lipid storage deposits, these dynamic and remarkable organelles have recently been implicated in a number of other cellular functions, ranging from protein storage and degradation to virus replication. Intracellular accumulation of LDs is also a hallmark feature of diverse human diseases including diabetes type II, obesity, hepatosteatosis, cancer, and atherosclerosis...
January 20, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28029275/oligodendroglial-cell-proliferation-arising-in-an-ovarian-mature-cystic-teratoma-clinicopathological-inmunohistochemical-and-ultrastructural-study-of-a-case-that-may-represent-an-oligodendroglioma
#3
Mónica Lizzette Serrano-Arévalo, Leonardo Saúl Lino-Silva, Hugo Ricardo Domínguez Malagón
Ovarian mature cystic teratoma (OMCT) is an ovarian benign neoplasm with excellent prognosis presenting components of the three germinal layers. However, transformation into a malignant neoplasm is a rare event (so-called somatic transformation). In most of the cases, the malignant component expresses as epidermoid carcinoma, but occasionally central nervous system tumors occur. Some of the previously reported tumors are astrocytoma, glioblastoma, and ependymoma. Somatic transformation of OMCT into an oligodendroglioma is exceptional...
December 28, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28029272/therapeutic-effect-of-mesenchymal-stem-cells-on-experimentally-induced-hypertensive-cardiomyopathy-in-adult-albino-rats
#4
Nariman A Khater, Sally A Selim, Samia A Abd El-Baset, Samar H Abd El Hameed
Hypertensive heart diseases affect millions of people worldwide. We aimed to investigate the hypertensive left ventricular histological changes and assess the effectiveness of bone marrow derived mesenchymal stem cells (MSCs) therapy in the treatment of hypertensive cardiomyopathy. Adult male albino rats were assigned into two groups: group I (control), group II (Experimental) subdivided into subgroup IIa (hypertensive) and subgroup IIb (stem cell therapy). Left ventricles (LVs) were processed for light and electron microscope...
December 28, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28029267/the-pathological-spectrum-associated-with-the-ultrastructural-finding-of-thin-glomerular-basement-membrane-a-tertiary-medical-city-experience-and-review-of-the-literature
#5
Hala Kfoury, Maria Arafah
BACKGROUND: Thin glomerular basement membrane (GBM) has been noted in several glomerular diseases including IgA nephropathy, focal segmental glomerulosclerosis (FSGS), Fabry's disease, and Alport's syndrome. We conducted this study to investigate the pathological ultrastructural spectrum of thin GBMs, to identify associated diseases, and to measure the GBM thickness in thin GBMs in our adult population. MATERIALS AND METHODS: All renal biopsies with thin GBM, diagnosed between 2010 and 2016, were retrieved and reviewed...
December 28, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27982723/the-antifibrogenic-effect-of-etanercept-on-development-of-liver-cirrhosis-induced-by-thioacetamide-in-rats
#6
Manal Abdul-Hamid, Rasha R Ahmed, Nadia Moustafa, Rehab Nady
Liver cirrhosis is an elevating cause of morbidity and mortality worldwide. TNF-α/TNF-R1 signal is implicated in progression of many liver diseases. This study provides histological and ultrastructural view that clarifies the effect of etanercept, a TNF-α inhibitor, on development of thioacetamide (TAA)-induced liver cirrhosis and the accompanied hemosiderosis in rats, highlighting the implication and distribution pattern of hepatic TNF-R1. Sixty male albino rats (Rattus norvegicus) were equally randomized into three groups...
December 16, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27960621/molecular-mechanisms-underlying-histological-and-biochemical-changes-induced-by-nitrate-in-rat-liver-and-the-efficacy-of-s-allylcysteine
#7
Asmaa A A Kattaia, Samia A Abd El-Baset, Eman M Mohamed, Rehab S Abdul-Maksou, Yara M Elfakharany
This study was designed to investigate structural and ultra-structural changes induced by nitrate in rat liver, examine their molecular basis, and evaluate the possible protective role of S-Allylcysteine (SAC). Adult male albino rats were assigned to: control, SAC, nitrate, and nitrate+ SAC groups. Serum ALT and AST were measured. Liver samples were processed for light and electron microscope examinations, biochemical analysis, real-time PCR, and immunohistochemistry of heat shock protein 70 (HSP70) and Bcl-2...
December 14, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27922337/does-ptis-exist-in-hpv-driven-tonsillar-carcinomas-an-ultrastructural-review-and-examination-of-two-cases
#8
Candice C Black, Christopher Ogomo
Many tonsillar tumors present clinically as cervical nodal metastases and the primary tumor is often difficult to find. HPV-driven tonsillar carcinoma begins in the reticulated crypt epithelium, possibly through viral integration. The basement membrane is not complete in the reticulated crypt epithelium, which may enhance the immune function. We examined the reticulated crypt epithelium in a normal case and five neoplastic tonsils with cervical metastasis as the presenting symptom to further investigate whether tonsil carcinoma in-situ exists...
December 6, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27880092/efficacy-of-zinc-oxide-nanoparticles-in-attenuating-pancreatic-damage-in-a-rat-model-of-streptozotocin-induced-diabetes
#9
Nashwa S Wahba, Sahar F Shaban, Asmaa A A Kattaia, Sara A Kandeel
Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27786616/transmission-electron-microscopic-evaluation-of-neuronal-changes-in-methylmercury-exposed-zebrafish-embryos-danio-rerio
#10
Said A Hassan, Sameh M Farouk, Louise C Abbott
Our work aimed to elucidate the ultrastructural changes associated with brain neurons in wild-type zebrafish embryos exposed to different concentrations of methylmercury. Zebrafish embryos were exposed to one of five concentrations of methylmercury (0 [negative control], 5, 10, 50, and 80 parts per billion) starting at six hours post fertilization (hpf). At 96 hpf, cells in the zebrafish embryo brains were examined using transmission electron microscopy. The developing neurons of the control embryos sowed normal cellular ultrastructure...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27786576/immunomodulatory-effect-of-gelatin-coated-silver-nanoparticles-in-mice-ultrastructural-evaluation
#11
Omar Bauomy Ahmed, Usama Taha Mahmoud, Sara Elganady, Allam Mohamed Nafady, Salah Mohamed Hassan Afifi
Silver nanoparticles (SNP) are used in many pharmaceutical, cosmetic, and industrial products already available in the market. Although they are considered relatively safe, many toxic and pathological alterations in different organs including immune organs were reported after SNP administration. In this study, 10-week-old male mice (n = 20) were divided into two groups. Ten mice received greenly synthesized gelatin-coated silver nanoparticles in a dose of 10 mg/kg body weight for five consecutive days while the other 10 received 0...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27762645/morphological-features-of-fascia-lata-in-relation-to-fascia-diseases
#12
Sylwia Szotek, Joanna Dawidowicz, Brian Eyden, Natalia Matysiak, Aleksander Czogalla, Grzegorz Dudzik, Anna Leśniewicz, Krzysztof Maksymowicz
Fascia lata is an important element of the fascial system, which forms the continuum of connective tissue throughout the body. This deep fascia envelops the entire thigh and hip area and its main function is to transmit mechanical forces generated by the musculoskeletal system of the lower extremities. Fascia lata is also known as a useful and easily harvested graft material. Despite its crucial role in lower extremity biomechanics and wide-ranging applications in plastic and reconstructive surgery, both the structure of fascia lata and particularly the cells populating this tissue are relatively unexplored and therefore poorly understood...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27736278/in-vivo-confocal-microscopy-analysis-of-enamel-defects-after-orthodontic-treatment-a-preliminary-study
#13
Vincenzo Grassia, Enrica Gentile, Dario Di Stasio, Abdolreza Jamilian, Giovanni Matarese, Fabrizia D'Apuzzo, Rossella Santoro, Letizia Perillo, Rosario Serpico, Alberta Lucchese
After orthodontic treatment with fixed appliances, bonded brackets and residual adhesive must be removed. This procedure should lead to restitutio ad integrum of the enamel or, at least, restore the enamel surface as closely as possible to its pre-treatment conditions. The purpose of this study is the in vivo assessment at a microscopic resolution of enamel surfaces after bracket debonding while avoiding the tooth extraction. Nine orthodontic patients who had brackets removed at the conclusion of orthodontic treatment were enrolled...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27736270/ultrastructural-changes-in-epithelial-cells-of-rats-exposed-to-low-concentration-of-hydrogen-sulfide-for-50-days
#14
Defne Yalçın Yeler, Murat Aydın, Peyami Turgay Hocaoğlu, Melike Koraltan, Hakan Özdemir, Tuğba Kotil, Mehmet Gül
Hydrogen sulfide (H2S) and other volatile sulfur compounds (VSCs) appear mainly in the oral air of patients with halitosis. It seems that VSCs are directly involved in the pathogenesis of gingival diseases. In previous studies, short-term (7 hours-4 days), high concentrations (5-400 ppm) of H2S applications on periodontal tissues have been evaluated in a culture medium. The aim of the present study was to investigate the potential effects of lower (equivalent to halitosis) concentrations of H2S on rat gingival tissue for longer-term inhalation...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27680498/observation-on-the-ultrastructure-morphology-of-hela-cells-treated-with-ethanol-statistical-analysis
#15
Fakhri Al-Bagdadi, Matthew J Young, James P Geaghan, Shaomian Yao, Humberto M Barona, Eduardo Martinez-Ceballos, Masami Yoshimura
It is estimated that 5.9% of all human deaths are attributable to alcohol consumption and that the harmful use of ethanol ranks among the top five risk factors for causing disease, disability, and death worldwide. Ethanol is known to disrupt phospholipid packing and promote membrane hemifusion at lipid bilayers. With the exception of mitochondria involved in hormone synthesis, the sterol content of mitochondrial membranes is low. As membranes that are low in cholesterol have increased membrane fluidity and are the most easily disordered by ethanol, we hypothesize that mitochondria are sensitive targets for ethanol damage...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27669128/diagnosis-of-congenital-and-infantile-nephrotic-syndromes-in-renal-biopsies-in-minas-gerais-brazil-six-case-reports
#16
Laura Penna Rocha, Fabiano Bichuette Custódio, Juliana Reis Machado, Lívia Helena de Morais Pereira, Maria Luiza Gonçalves Dos Reis Monteiro, Valéria Lima Laterza, Marlene Antônia Dos Reis, Rosana Rosa Miranda Corrêa
Congenital or infantile nephrotic syndromes (CNS/INS) correspond to a heterogeneous group of rare diseases in which glomerular renal dysfunction and proteinuria are prominent. The aim of this study is to present six cases of possible CNS/INS with diagnoses based on clinical findings and especially histological, ultrastructural, and immunohistochemical characteristics of renal biopsies. Four cases are presented with diffuse mesangial sclerosis, one of them possibly part of Denys-Drash syndrome and two cases with CNS probably of the Finnish type in patients between 3 months old and 13 years old...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27661791/podocytic-infolding-glomerulopathy-a-case-report
#17
Kye Won Kwon, Hyeon Joo Jeong, Jang Han Lee
Podocytic infolding glomerulopathy (PIG) is a rare glomerular abnormality involving glomerular basement membrane (GBM) bubbling viewable by light microscopy, extensive invagination of the podocytic cytoplasm, and the presence of microstructures viewable by electron microscopy. PIG was proposed as a new disease entity in 2008. However, cases have been reported exclusively in Japan and no case reports outside Japan have been published. Here, we report a case of PIG in a 44-year-old Korean female. The patient showed mild proteinuria without renal functional impairment or other systemic diseases...
November 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27669398/aggressive-human-neuroblastomas-show-a-massive-increase-in-the-numbers-of-autophagic-vacuoles-and-damaged-mitochondria
#18
Gordana Samardzija, Tamara Kravic Stevovic, Slavisa Djuricic, Dragomir Djokic, Marina Djurisic, Darko Ciric, Tamara Martinovic, Vladimir Bumbasirevic, Dragana Vujic
Autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance in neuroblastoma (NB). This study was conducted to analyze the ultrastructural features of peripheral neuroblastic tumors (pNTs) and identify the relation of the types of NTs, the proliferation rate, and MYCN gene amplification with a number of autophagic vacuoles. Our results indicate that aggressive human NBs show a massive increase in the number of autophagic vacuoles associated with proliferation rate and that alteration of the mitochondria might be an important factor for the induction of autophagy in NTs...
September 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27598972/prenatal-and-lactation-nicotine-exposure-affects-morphology-and-function-of-brown-adipose-tissue-in-male-rat-offspring
#19
Jie Fan, Jie Ping, Wan-Xia Zhang, Yi-Song Rao, Han-Xiao Liu, Jing Zhang, You-E Yan
The aim of this study was to investigate the effects of prenatal and lactation nicotine exposure on the morphology and function of brown adipose tissue (BAT) in male rat offspring. We conducted a morphological assay and gene expression study of interscapular BAT (iBAT) in male rat offspring. The male offspring from nicotine-exposed dams exhibited higher body weight and iBAT weight. Hematoxylin and eosin staining and transmission electron microscopy showed that iBAT from nicotine-exposed male offspring presented a "whitening" phenotype characterized by lipid droplet accumulation and impaired mitochondria with a randomly oriented and fractured cristae...
September 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27594347/vitiligo-the-story-from-within-a-transmission-electron-microscopic-study-before-and-after-narrow-band-ultraviolet-b
#20
Marwa M Fawzy, Zeinab M El Maadawi, Rehab A Hegazy, Nesrin S Abd El Fatah
Melanocyte loss is the main feature of vitiligo, but evidence refers to pathological multiplayers. Transmission electron microscopy was utilized to further explore vitiligo before and after narrow-band ultraviolet B (NB-UVB) therapy. Skin biopsies were retrieved from lesional and perilesional skin and compared to normal control skin. Sections were examined for melanocytes and keratinocytes and the number of melanosomes and thickness of basal lamina were measured. In lesional skin, keratinocytes revealed two types of degeneration with a significant increase in the mean thickness of basal lamina and decrease in the number of melanosomes...
September 2016: Ultrastructural Pathology
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