Jenna H Burton, Stephen Albert Johnston, David M Vail, Jens C Eickhoff, Kathryn F Sykes, Justin R Brown, Luhui Shen, Ana Gervassi, Rodney L Page, Jennifer L Willcox, Sami Al-Nadaf, Amanda L Willis, Danielle Biggs, Jessica Ralston, Irene Mok, Ilene D Kurzman, Michael K Huelsmeyer, Rubi Hayim, Brittany M Smith, Douglas H Thamm
Preventative anti-cancer vaccination strategies have long been hampered by the challenge of targeting the diverse array of potential tumor antigens, with successes to date limited to cancers with viral etiologies. Identification and vaccination against frameshift neoantigens conserved across multiple species and tumor histologies is a potential cancer preventative strategy currently being investigated. Companion dogs spontaneously develop cancers at a similar incidence to those in people and are a complementary comparative patient population for the development of novel anti-cancer therapeutics...
November 29, 2023: Veterinary Immunology and Immunopathology