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Journal of Reproductive Immunology

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https://www.readbyqxmd.com/read/29421625/microglia-the-missing-link-in-maternal-immune-activation-and-fetal-neurodevelopment-and-a-possible-link-in-preeclampsia-and-disturbed-neurodevelopment
#1
Jelmer R Prins, Sharon Eskandar, Bart J L Eggen, Sicco A Scherjon
Disturbances in fetal neurodevelopment have extensively been related to neurodevelopmental disorders in early and later life. Fetal neurodevelopment is dependent on adequate functioning of the fetal immune system. During pregnancy, the maternal immune system is challenged to both tolerate the semi-allogenic fetus and to protect the mother and fetus from microbes. The fetal immune system is influenced by maternal immune disturbances; therefore, perturbations in maternal immunity likely do not only alter pregnancy outcome but also alter fetal neurodevelopment...
January 31, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29421624/comprehensive-overview-of-murine-epididymal-mononuclear-phagocytes-and-lymphocytes-unexpected-populations-arise
#2
Allison Voisin, Marjorie Whitfield, Christelle Damon-Soubeyrand, Chantal Goubely, Joëlle Henry-Berger, Fabrice Saez, Ayhan Kocer, Joël R Drevet, Rachel Guiton
Despite increasing evidence that epididymal immune disorders can lead to infertility, the cells and mechanisms underlying epididymal immunity remain poorly understood. In this study, we propose a rather exhaustive overview of innate and adaptive immune cells present in the murine caput and cauda epididymis. Using flow cytometry and a wide set of markers, we screened the broadest panel of immune cells ever, in this organ. For the first time, we unequivocally quantified the innate populations of monocytes, macrophages, and dendritic cells subtypes...
January 31, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29367099/mid-gestational-changes-in-cervicovaginal-fluid-cytokine-levels-in-asymptomatic-pregnant-women-are-predictive-markers-of-inflammation-associated-spontaneous-preterm-birth
#3
Emmanuel Amabebe, David R Chapman, Victoria L Stern, Graham Stafford, Dilly O C Anumba
OBJECTIVES: Perturbation of the choriodecidual space before the onset of spontaneous preterm birth (sPTB) could lead to a concomitant rise in both cervicovaginal fluid (CVF) cytokine and fetal fibronectin (FFN), and assessing the concentrations of both markers could improve the prediction of sPTB (delivery before 37 completed weeks of gestation). Therefore, we prospectively determined mid-trimester changes in CVF cytokine and FFN concentrations, and their predictive capacity for sPTB in asymptomatic pregnant women...
January 10, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29306096/embryotoxic-cytokines-potential-roles-in-embryo-loss-and-fetal-programming
#4
REVIEW
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
December 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29306095/effect-of-polybrominated-diphenyl-ether-congeners-on-placental-cytokine-production
#5
Yuko Arita, Corinne Yeh, Theodosia Thoma, Darios Getahun, Ramkumar Menon, Morgan R Peltier
Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta...
December 21, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29253794/unsaturated-fatty-acids-protect-trophoblast-cells-from-saturated-fatty-acid-induced-autophagy-defects
#6
Ye-Ji Hong, Hyo-Ju Ahn, Jongdae Shin, Joon H Lee, Jin-Hoi Kim, Hwan-Woo Park, Sung Ki Lee
Dysregulated serum fatty acids are associated with a lipotoxic placental environment, which contributes to increased pregnancy complications via altered trophoblast invasion. However, the role of saturated and unsaturated fatty acids in trophoblastic autophagy has yet to be explored. Here, we demonstrated that prolonged exposure of saturated fatty acids interferes with the invasiveness of human extravillous trophoblasts. Saturated fatty acids (but not unsaturated fatty acids) inhibited the fusion of autophagosomes and lysosomes, resulting in the formation of intracellular protein aggregates...
December 14, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29253795/new-insights-into-early-and-late-onset-subgroups-of-preeclampsia-from-longitudinal-versus-cross-sectional-analysis-of-urinary-inositol-phosphoglycan-p-type
#7
Arnaud Dominique L'Omelette, Lalita Dawonauth, Laurens Rademacher, Pierre-Yves Robillard, Marco Scioscia, Sarojini Jankee, Man Yoon Lee Kwai Yan, Jeeawoody B Razgia, Thomas W Rademacher
Most pre-eclampsia (PE) studies have used cross-sectional data to derive conclusions regarding the pathophysiology of the condition. This has led to the concept that there exists early (<34 weeks) and late-onset (>34 weeks) disease according to gestational age at diagnosis. Survival time models have predicted that if the pregnancy was to continue indefinitely, all women would develop PE. In this study we have performed a longitudinal analysis of the urinary biomarker, inositol phosphoglycan (IPG), in a cohort of women giving birth in Mauritius (n-920)...
December 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29253793/chronic-inflammation-and-impaired-development-of-the-preterm-brain
#8
REVIEW
Laura Bennet, Simerdeep Dhillon, Chris A Lear, Lotte van den Heuij, Victoria King, Justin M Dean, Guido Wassink, Joanne O Davidson, Alistair Jan Gunn
The preterm newborn is at significant risk of neural injury and impaired neurodevelopment. Infants with mild or no evidence of injury may also be at risk of altered brain development, with evidence impaired cell maturation. The underlying causes are multifactorial and include exposure of both the fetus and newborn to hypoxia-ischemia, inflammation (chorioamnionitis) and infection, adverse maternal lifestyle choices (smoking, drug and alcohol use, diet) and obesity, as well as the significant demand that adaptation to post-natal life places on immature organs...
November 26, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29195119/interleukin-11-is-upregulated-in-preeclampsia-and-leads-to-inflammation-and-preeclampsia-features-in-mice
#9
REVIEW
Amy Winship, Eva Dimitriadis
Preeclampsia is a dangerous pregnancy complication, which is often associated with fetal growth restriction and can have serious life-long effects for both mother and baby. While the establishment of the placenta in the first trimester is the sentinel event in the development of preeclampsia little is known of the critical mechanisms of placentation that lead to the syndrome. Locally produced inflammatory cytokines are thought to play a role in the development of preeclampsia. This review summarizes the evidence that interleukin 11 is dysregulated in preeclampsia and contributes to the initiation of preeclampsia via effects on placentation...
November 26, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29406209/retraction-notice-to-doxycycline-alters-the-expression-of-matrix-metalloproteases-in-the-endometrial-cells-exposed-to-ovarian-steroids-and-pro-inflammatory-cytokine-jri-73-2-april-2017-118-129
#10
Rongxiu Li, Xiaoping Luo, David F Archer, Nasser Chegini
No abstract text is available yet for this article.
February 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29329080/intrauterine-inflammatory-activation-functional-progesterone-withdrawal-and-the-timing-of-term-and-preterm-birth
#11
REVIEW
Jeffrey A Keelan
The central role of inflammatory processes in labour and delivery is now well-recognised. However, the biomolecular, immunological and endocrine mechanisms involved in the labour process, and the clinical manifestations of inflammation in pregnancy, are complex, variable and modulated by factors such as aetiology, ethnicity and gestational age. In this review, evidence is presented of the pivotal relationship between progesterone and inflammation in pregnancy in terms of determining the timing of labour and delivery...
February 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29222972/factors-associated-with-adverse-pregnancy-outcomes-in-women-with-systematic-lupus-erythematosus
#12
Masashi Deguchi, Yoko Maesawa, Shino Kubota, Mayumi Morizane, Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
The aim of this prospective study was to determine clinical factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus (SLE). Fifty-six pregnancies from 46 women with SLE were enrolled. Risk factors for pregnancy loss, premature delivery, hypertensive disorders of pregnancy (HDP), and light-for-date neonate (LFD), were evaluated. Univariate and multivariate logistic regression analyses revealed a history of two or more pregnancy losses before 10 gestational weeks (GW) (OR 11...
February 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29161617/early-pregnancy-immune-biomarkers-in-peripheral-blood-may-predict-preeclampsia
#13
M D Salazar Garcia, Y Mobley, J Henson, M Davies, A Skariah, S Dambaeva, A Gilman-Sachs, K Beaman, C Lampley, J Kwak-Kim
We performed a prospective cohort study in 197 pregnant women. Peripheral blood was collected between 5 and 16 weeks of gestation. Intracellular cytokine analysis and immunophenotype were performed by flow-cytometry. Serum levels of cytokines and chemokines were analyzed by multiplex assay. 86 patients were eligible for the analysis and 10.5% (n=9) developed preeclampsia. Patients with preeclampsia had significantly higher percentage of CD3+CD4+TNFα+ T helper (Th) 1 cells (45.4±10.3 vs 37.1±8.5, P=0.032) and CD3+CD4+IL17+ Th 17 cells (2...
November 2, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29107859/the-effect-of-the-progesterone-induced-blocking-factor-pibf-on-e-cadherin-expression-cell-motility-and-invasion-of-primary-tumour-cell-lines
#14
Tímea Balassa, Gergely Berta, László Jakab, Noémi Bohonyi, Júlia Szekeres-Bartho
In addition to being immunomodulatory, Progesterone-Induced Blocking Factor (PIBF) plays a role in cell cycle regulation and invasion. The full length protein is associated with the pericentriolar satellites and as such, it is crucial for maintaining the integrity of spindle poles during mitosis. Another suggestive evidence for the involvement of PIBF in tumour progression is the fact that the PIBF gene has been identified on chromosome 13 in the region associated with breast cancer susceptibility. Earlier we showed that PIBF differentially regulates the invasiveness of trophoblast and tumour cell lines...
November 2, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29049918/dc-sign-expression-in-hofbauer-cells-may-play-an-important-role-in-immune-tolerance-in-fetal-chorionic-villi-during-the-development-of-preeclampsia
#15
Seung Woo Yang, Eun Hee Cho, So Young Choi, Yun Kyung Lee, Jae Hyun Park, Min Kyung Kim, Jin Yeon Park, Hyeong Jwa Choi, Jeong Ik Lee, Hyun Myung Ko, Seung Hwa Park, Han Sung Hwang, Young Sun Kang
Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of maternal mortality in the field of obstetrics, and the innate immunological role of maternal decidual macrophages is well known. In this study, we assessed the differential phenotypes and marker expression in fetal macrophages, known as dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)-positive Hofbauer cells...
November 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29035757/pulmonary-hypertension-associated-with-bronchopulmonary-dysplasia-in-preterm-infants
#16
REVIEW
Christine B Bui, Merrin A Pang, Arvind Sehgal, Christiane Theda, Jason C Lao, Philip J Berger, Marcel F Nold, Claudia A Nold-Petry
Bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension (BPD-PH) are chronic inflammatory cardiopulmonary diseases with devastating short- and long-term consequences for infants born prematurely. The immature lungs of preterm infants are ill-prepared to achieve sufficient gas exchange, thus usually necessitating immediate commencement of respiratory support and oxygen supplementation. These therapies are life-saving, but they exacerbate the tissue damage that is inevitably inflicted on a preterm lung forced to perform gas exchange...
November 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29153978/the-endometria-of-women-with-endometriosis-exhibit-dysfunctional-expression-of-complement-regulatory-proteins-during-the-mid-secretory-phase
#17
Wilder A Palomino, Chandrakant Tayade, Felipe Argandoña, Luigi Devoto, Steven L Young, Bruce A Lessey
The control of complement activation within embryo-endometrium environment is critical for embryo survival. Cell evasion from complement attack requires interaction of complement regulatory proteins (CRPs) with cell adhesion αvβ3 integrin. We aim to compare the expression of CRPs in endometria of women with and without endometriosis and to examine the molecular interaction of decay accelerating factor (DAF) with αvβ3 integrin. Endometrial expression of Membrane cofactor protein (CD46), Decay accelerating factor (DAF), Membrane attack complex inhibitory factor (CD59) and β3 integrin subunit were determined through menstrual cycle by immunohistochemistry...
October 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29055792/the-effect-of-acetyl-salicylic-acid-aspirin-on-trophoblast-endothelial-interaction-in-vitro
#18
Bei Xu, Renuka Shanmugalingam, Katrina Chau, Suzanne Pears, Annemarie Hennessy, Angela Makris
Early administration of low dose acetyl salicylic acid (Aspirin) in high risk women reduces the risk of early onset preeclampsia. This study aims to investigate the effect of aspirin on trophoblast integration and the its effect on angiogenic and invasive pathways in an in-vitro model of preeclampsia. Red fluorescent-labeled human uterine myometrial microvascular endothelial cells (UtMVECs) were seeded on matrigel to form endothelial networks. Green fluorescent-labeled trophoblastic HTR-8/SVneo cells were co-cultured with the endothelial networks with/without TNF-a (0...
October 18, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29055791/the-role-of-decidual-immune-cells-on-human-pregnancy
#19
REVIEW
Su Liu, Lianghui Diao, Chunyu Huang, Yuye Li, Yong Zeng, Joanne Y H Kwak-Kim
The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and develop in the uterus, despite being recognized by the maternal immune cells. Within the innate immune system, decidual natural killer cells and antigen presenting cells (including macrophages and dendritic cells) that comprise a large proportion of the decidual leukocyte populations play an important role in modulating trophoblast invasion, angiogenesis and vascular remodeling. On the other hand, within the adaptive immune system, CD8(+) T cells, effector CD4(+) T cells, Foxp3(+) regulatory T cells and CD4(+)HLA-G(+) suppressor T cells are identified as potential players in maintaining immune tolerance toward the semi-allogeneic fetus...
October 18, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29136520/characterization-of-myeloid-cell-populations-in-human-testes-collected-after-sex-reassignment-surgery
#20
Rosalie Ponte, Franck P Dupuy, Fadi Brimo, Vikram Mehraj, Pierre Brassard, Maud Belanger, Ekaterina Yurchenko, Mohammad-Ali Jenabian, Nicole F Bernard, Jean-Pierre Routy
The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution and frequency in human testis remain poorly described. To overcome the challenges related to tissue sampling, we obtained testicular tissue from men under hormonal therapy who elected to have sex reassignment surgery (SRS)...
October 14, 2017: Journal of Reproductive Immunology
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