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Journal of Reproductive Immunology

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https://www.readbyqxmd.com/read/28505516/induction-of-experimental-autoimmune-orchitis-by-immunization-with-xenogenic-testicular-germ-cells-in-mice
#1
Ning Qu, Hayato Terayama, Yoshie Hirayanagi, Miyuki Kuramasu, Yuki Ogawa, Shogo Hayashi, Shuichi Hirai, Munekazu Naito, Masahiro Itoh
We previously showed that immunization of mice with syngeneic or allogeneic testicular germ cells (TGC) alone induces autoimmune inflammation in the testes without using any adjuvant. In the present study, we examined testicular autoimmune response against xenogenic TGC antigens in mice. The mice were immunized with murine, rat or guinea pig TGC and then the histopathology, delayed type hypersensitivity (DTH) response and humoral autoimmunity were investigated. The results showed that immunization with not only murine but also rat TGC caused experimental autoimmune orchitis (EAO) with hypospermatogenesis in mice, while that with guinea pig TGC could not...
April 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28482188/pregnancy-favors-the-expansion-of-circulating-functional-follicular-helper-t-cells
#2
Clarice Monteiro, Taissa M Kasahara, José Roberto Castro, Priscila M Sacramento, Joana Hygino, Newton Centurião, Tatiane Cassano, Lana M Ferreira Lopes, Simone Leite, Vander Guimarães Silva, Sudhir Gupta, Cleonice A M Bento
Pregnancy favors antibody production, and some evidence has suggested a direct effect of estrogen on B cells. The impact of pregnancy on circulating follicular helper T (TFH) cells, typically identified by the expression of CD45RO and CXCR5, has not been previously investigated. Here, the percentage of TFH cells, co-expressing or not PD-1, ICOS, or CXCR3 markers was significantly higher in pregnant women (PW) as compared with non-pregnant ones (nPW). Furthermore, the percentage of CXCR3(+) TFH cells able to produce IL-6, IL-21, and IL-10 was significantly higher in PW than nPW...
April 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28441551/treating-normal-early-gestation-placentae-with-preeclamptic-sera-produces-extracellular-micro-and-nano-vesicles-that-activate-endothelial-cells
#3
Xirong Xiao, Fengyi Xiao, Mingzhi Zhao, Mancy Tong, Michelle R Wise, Peter R Stone, Lawrence W Chamley, Qi Chen
OBJECTIVES: Preeclampsia is characterised by systemic endothelial cell dysfunction thought to be triggered by toxic/dangerous factors from the placenta, including placental extracellular vesicles (EVs). Why placental EVs become toxic is unknown. We previously reported that preeclamptic sera produced toxic/dangerous placental macrovesicles but whether small EVs are also toxic/dangerous in preeclampsia is unknown. STUDY DESIGN: First trimester placental explants were treated with 10% preeclamptic or control sera (n=10) for 24h...
April 14, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28463710/-what-do-we-know-about-regulatory-t-cells-and-endometriosis-a-systematic-review
#4
REVIEW
Isabela Bottura Leite de Barros, Helena Malvezzi, Bárbara Yasmin Gueuvoghlanian-Silva, Carla Azevedo Piccinato, Luiz Vicente Rizzo, Sergio Podgaec
Endometriosis is a benign, chronic inflammatory disease that presents alterations in immune response that can be detected in eutopic endometrium, peritoneal fluid and peripheral blood of affected women. Regulatory T (TReg) cells are a subpopulation of T lymphocytes specialized in immune regulation that seem to participate in the development of endometriosis, by suppressing the immune response and favoring the establishment of lesions. Our aim was to review the scientific literature that evaluates TReg cell phenotypes in the context of endometriosis...
April 10, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28432903/the-decidua-of-preeclamptic-like-bph-5-mice-exhibits-an-exaggerated-inflammatory-response-during-early-pregnancy
#5
C Y Heyward, J L Sones, H E Lob, L C Yuen, K E Abbott, W Huang, Z R Begun, S D Butler, A August, C A Leifer, R L Davisson
Preeclampsia is a devastating complication of pregnancy characterized by late-gestation hypertension and proteinuria. Because the only definitive treatment is delivery of the fetus and placenta, preeclampsia contributes to increased morbidity and mortality of both mother and fetus. The BPH/5 mouse model, which spontaneously develops a syndrome strikingly similar to preeclampsia, displays excessive inflammation and suppression of inflammation improves pregnancy outcomes. During early pregnancy, decidual macrophages play an important role in promoting maternal tolerance to fetal antigens and regulating tissue remodeling, two functions that are critical for normal placental development...
April 10, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28399439/maternal-and-pregnancy-related-factors-affecting-human-milk-cytokines-among-peruvian-mothers-bearing-low-birth-weight-neonates
#6
Mara Zambruni, Alex Villalobos, Anoma Somasunderam, Sarah Westergaard, Maitreyee Nigalye, Christie G Turin, Jaime Zegarra, Sicilia Bellomo, Erik Mercado, Theresa J Ochoa, Netanya S Utay
Several cytokines have been detected in human milk but their relative concentrations differ among women and vary over time in the same person. The drivers of such differences have been only partially identified, while the effect of luminal cytokines in the fine-regulation of the intestinal immune system is increasingly appreciated. The aim of this study was to investigate the associations between obstetrical complications and human milk cytokine profiles in a cohort of Peruvian women giving birth to Low Birth Weight (LBW) infants...
April 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28388469/higher-prevalence-of-colonization-with-gardnerella-vaginalis-and-gram-negative-anaerobes-in-patients-with-recurrent-miscarriage-and-elevated-peripheral-natural-killer-cells
#7
R J Kuon, R Togawa, K Vomstein, M Weber, T Goeggl, T Strowitzki, U R Markert, S Zimmermann, V Daniel, A H Dalpke, B Toth
The role of vaginal infections in recurrent miscarriage (RM) is discussed controversially and screening is not recommended in international guidelines. Peripheral and uterine NK cells (pNK, uNK) play an important role in the establishment of a healthy pregnancy and are targets of immune diagnostics in RM patients. The aim of this study was to analyze the composition of the vaginal microbiota in RM patients and to correlate the findings to clinical characteristics as well as NK cell parameters. In total, n=243 RM patients with ≥3 consecutive miscarriages were recruited between 11/2011 and 03/2016...
March 30, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28441552/natural-killer-cell-activity-in-women-with-recurrent-miscarriage-etiology-and-pregnancy-outcome
#8
Yasuhiko Ebina, Yukari Nishino, Masashi Deguchi, Yoko Maesawa, Yuki Nakashima, Hideto Yamada
This study aimed to evaluate whether natural killer (NK) cell activity was associated with the etiology of recurrent miscarriage (RM), and to evaluate the predictive value of NK cell activity for outcomes of following pregnancies in women with RM. Peripheral NK cell activity was measured in 160 non-pregnant women with a history of two or more miscarriages. This activity was compared according to the etiology of RM and to pregnancy outcomes in women who became pregnant. NK cell activity in women with unexplained RM was significantly higher than that in those with known etiologies of RM...
April 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28267635/associations-between-fetal-hla-g-genotype-and-birth-weight-and-placental-weight-in-a-large-cohort-of-pregnant-women-possible-implications-for-hla-diversity
#9
Johanne Emmery, Ole B Christiansen, Line Lynge Nilsson, Mette Dahl, Peter Skovbo, Anna Margrethe Møller, Rudi Steffensen, Thomas Vauvert F Hviid
Birth weight and placental weight are crucial parameters for the survival of fetuses and newborns in mammals. High variation in the MHC is important for an effective adaptive immune response. The maternal immune system must be controlled in relation to the semi-allogenic fetus. The immunoregulatory HLA/MHC class Ib gene, HLA-G, is strongly expressed on extravillous trophoblast cells. We investigated birth weight and placental weight of the newborns in mothers heterozygous for an HLA-G 14bp insertion (Ins)/deletion (Del) gene polymorphism...
February 20, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28196761/effect-of-gonadotropin-releasing-hormone-vaccination-on-t-lymphocyte-changes-in-male-rats
#10
Shiping Su, Xiuhong Zhou, Xiaorong Zhang, Fuigui Fang
The aim of this study was to detect the effect of immunization against gonadotropin-releasing hormone (GnRH) on cell-meditated immunity. Three-week-old male Sprague-Dawley rats (n=32) were randomly and equally assigned to two groups: 1) GnRH-tandem-ovalbumin immunized group; and 2) the control group (injected with an equivalent Al(OH)3 adjuvant). Blood samples were collected at two-week intervals to assess the level of GnRH-specific antibodies and testosterone. Moreover, blood and thymus samples were also collected to analyze the T lymphocyte subpopulations one and two months after the last booster immunization...
February 7, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28228286/reproductive-immunology-time-to-look-forward
#11
EDITORIAL
Gendie Lash
No abstract text is available yet for this article.
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28043035/pibf-positive-uterine-nk-cells-in-the-mouse-decidua
#12
Agnes Bogdan, Gergely Berta, Julia Szekeres-Bartho
Though uterine NK cells (u NK cells) contain cytotoxic granules, and selectively over- express the genes of perforin and granzymes, during normal pregnancy, they are not cytotoxic. Progesterone is indispensable for the establishment and maintenance of pregnancy both in humans and in mice. Mouse uterine NK cells do not express the classical progesterone receptor, yet progesterone affects the recruitment and function of uterine NK cells, the latter partly via the Progesterone-Induced Blocking Factor (PIBF). We demonstrated PIBF positive granulated cells in the mouse decidua...
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27865124/the-killer-cell-story-in-recurrent-miscarriage-association-between-activated-peripheral-lymphocytes-and-uterine-natural-killer-cells
#13
R J Kuon, K Vomstein, M Weber, F Müller, C Seitz, S Wallwiener, T Strowitzki, E Schleussner, U R Markert, V Daniel, B Toth
Peripheral and uterine NK cells (pNK, uNK) can be distinguished according to their receptor expression. Recent studies indicate an association of elevated pNK and uNK with recurrent miscarriage (RM). This study aimed to analyze pNK and uNK in patients with RM and healthy controls. Out of n=590 RM patients screened according to a standard diagnostic protocol, n=268 couples with ≥3 consecutive RM were identified. Subgroups consisted of n=151 primary RM (pRM), n=85 secondary RM (sRM), n=32 tertiary RM (tRM) and n=42 healthy controls...
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27613663/update-of-syncytiotrophoblast-derived-extracellular-vesicles-in-normal-pregnancy-and-preeclampsia
#14
REVIEW
Dionne Tannetta, Ieva Masliukaite, Manu Vatish, Christopher Redman, Ian Sargent
The release of extracellular vesicles (EV) by the syncytiotrophoblast (STB) may be an important mechanism by which the placenta signals to the mother. STB derived EV (STBEV) are comprised predominantly of exosomes (50-150nm) and microvesicles (100-1000nm) that contain bioactive mediators such as proteins, nucleic acids and lipids. They, along with larger syncytial nuclear aggregates are released by the STB into the maternal circulation throughout gestation in normal pregnancy where they appear to have an immunoregulatory role, inhibiting T cell and NK cell responses...
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27523927/cytotoxic-potential-of-decidual-nk-cells-and-cd8-t-cells-awakened-by-infections
#15
Ângela C Crespo, Anita van der Zwan, João Ramalho-Santos, Jack L Strominger, Tamara Tilburgs
To establish a healthy pregnancy the maternal immune system must tolerate fetal allo-antigens, yet remain competent to respond to infections. The ability of decidual NK cells (dNK) to promote migration of fetal extravillous trophoblasts (EVT) and placental growth as well as the capacity of EVT to promote immune tolerance are topics of high interest and extensive research. However, the problem of how dNK and decidual CD8+ T cells (CD8+ dT) provide immunity to infections of the placenta and the mechanisms that regulate their cytolytic function has thus far largely been ignored...
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27498991/innate-immunity-and-the-sensing-of-infection-damage-and-danger-in-the-female-genital-tract
#16
REVIEW
Iain Martin Sheldon, Siân-Eleri Owens, Matthew Lloyd Turner
Tissue homeostasis in the female genital tract is challenged by infection, damage, and even physiological events during reproductive cycles. We propose that the evolutionarily ancient system of innate immunity is sufficient to sense and respond to danger in the non-pregnant female genital tract. Innate immunity produces a rapidly inducible, non-specific response when cells sense danger. Here we provide a primer on innate immunity and discuss what is known about how danger signals are sensed in the endometrium and ovary, the impact of inflammatory responses on reproduction, and how endocrinology and innate immunity are integrated...
February 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28131097/downregulation-of-indoleamine-2-3-dioxygenase-expression-in-the-villous-stromal-endothelial-cells-of-placentas-with-preeclampsia
#17
Naoyuki Iwahashi, Madoka Yamamoto, Sakiko Nanjo, Saori Toujima, Sawako Minami, Kazuhiko Ino
INTRODUCTION: Previous studies have shown that indoleamine 2, 3-dioxygenase (IDO), an immunosuppressive enzyme that converts tryptophan to kynurenine, is expressed in the placenta and might play a role in the maintenance of pregnancy, although its associations with the pathogeneses of preeclampsia (PE) and fetal growth restriction (FGR) remain unclear. The objective of this study was to investigate the differences in IDO expression among normal, PE, and FGR placentas, and the associations between IDO expression and clinical symptoms, or the expression of fms-like tyrosine kinase receptor-1 (Flt-1)...
January 23, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28122284/periodic-elevation-of-regulatory-t-cells-on-the-day-of-embryo-transfer-is-associated-with-better-in-vitro-fertilization-outcome
#18
Wen-Juan Wang, Fu-Jun Liu, Xia Zhang, Xue-Mei Liu, Qing-Lan Qu, Feng-Hua Li, Li-Li Zhuang, Xiao-Xiao Li, Cui-Fang Hao
Treg cells have been shown to be important in maintaining maternofetal tolerance, but the expression of Tregs in assisted reproductive technology (ART) in women on the day of embryo transfer (D0), 5days (D5) and 14days after ET (D14); the related factors influencing the expression levels of Tregs; the proliferation ability and the relevant cytokine epression by Tregs on D14 have not been investigated. In this study, 124 women undergoing in vitro fertilization-intracytoplasmic sperm injection (IVF/ICSI) were enrolled...
January 19, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28064076/drospirenone-reduces-inflammatory-cytokines-vascular-endothelial-growth-factor-vegf-and-nerve-growth-factor-ngf-expression-in-human-endometriotic-stromal-cells
#19
Tomoko Makabe, Kaori Koga, Mariko Miyashita, Arisa Takeuchi, Fusako Sue, Ayumi Taguchi, Yoko Urata, Gentaro Izumi, Masashi Takamura, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
Drospirenone has been used as a progestin in oral contraceptives with ethinyl estradiol (DRSP/EE) and is expected to regulate endometriosis, however, the direct effects of drospirenone on endometriosis have not been clarified. The aim of this study was to evaluate the anti-inflammatory, anti-angiogenic and anti-neurogenic effects of drospirenone on endometriotic stromal cells (ESC). ESC isolated from endometriotic tissues were obtained from patients during laparoscopic surgery for ovarian endometriosis. ESC were exposed to IL-1β and cultured in the absence or presence of drospirenone...
December 29, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28122664/preterm-birth-inflammation-fetal-injury-and-treatment-strategies
#20
Ashley K Boyle, Sara F Rinaldi, Jane E Norman, Sarah J Stock
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain...
December 2, 2016: Journal of Reproductive Immunology
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