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Journal of Reproductive Immunology

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https://www.readbyqxmd.com/read/29886307/innate-immune-responses-to-toll-like-receptor-stimulation-are-altered-during-the-course-of-pregnancy
#1
Susanne Maria Ziegler, Cai Niklaas Feldmann, Sven Hendrik Hagen, Laura Richert, Tanja Barkhausen, Janina Goletzke, Virginija Jazbutyte, Gloria Martrus, Wilhelm Salzberger, Thomas Renné, Kurt Hecher, Anke Diemert, Petra Clara Arck, Marcus Altfeld
During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. In a longitudinal study of pregnant women, we investigated innate immune cell function in response to toll-like receptors (TLR) 4 and 7 stimulation, two TLR pathways playing a critical role in early innate immune recognition of bacteria and viruses...
May 24, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29803192/sleep-duration-and-c-reactive-protein-associations-among-pregnant-and-non-pregnant-women
#2
Calliope Holingue, Jocelynn T Owusu, Kenneth A Feder, Adam P Spira
Pregnant women experience more sleep disturbances and greater systemic inflammation than non-pregnant women. However, the few studies that have examined the links between sleep and inflammation in pregnant women have been in clinical samples. We examined whether sleep duration is associated with C-reactive protein (CRP) levels, a marker of inflammation, in pregnant and non-pregnant women in a population-based sample of US women. Participants were 2865 women of reproductive age (aged 20-44 years) in the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of Americans...
May 23, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29843114/auto-antibodies-against-the-angiotensin-ii-type-i-receptor-in-women-with-uteroplacental-acute-atherosis-and-preeclampsia-at-delivery-and-several-years-postpartum
#3
Amalie Bjerke Rieber-Mohn, Meryam Sugulle, Gerd Wallukat, Patji Alnæs-Katjavivi, Gro Leite Størvold, Nils Bolstad, Christopher Wg Redman, Ralf Dechend, Anne Cathrine Staff
BACKGROUND: Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies at the angiotensin-II type 1 receptor (AT1 -AA) are increased in preeclampsia. We hypothesized an association between AT1 -AA at delivery and postpartum with acute atherosis in pregnancy...
May 22, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29800761/soluble-inflammatory-mediators-induce-transcriptional-re-organization-that-is-independent-of-dna-methylation-changes-in-cultured-human-chorionic-villous-trophoblasts
#4
Kaiyu Jiang, Laiping Wong, Yanmin Chen, Xiaoyun Xing, Daofeng Li, Ting Wang, James N Jarvis
The studies proposed here were undertaken to test the hypothesis that, under specific circumstances (e.g., a strong enough inflammatory stimulus), genes that are repressed at the maternal-fetal interface via DNA methylation might be de-methylated, allowing either a maternal immune response to the semi-allogenic fetus or the onset of early labor. Chorionic trophoblasts (CT) were isolated from fetal membranes, followed by incubation with medium from LPS-activated PBMC or resting PBMC medium for 2 h. RNA and DNA were isolated from the cells for RNA-seq and DNA methylation studies...
May 22, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29934094/soluble-cd200-in-secretory-phase-endometriosis-endometrial-venules-may-explain-endometriosis-pathophysiology-and-provide-a-novel-treatment-target
#5
David A Clark, Jennifer M Dmetrichuk, Sukhbinder Dhesy-Thind, Mark A Crowther, Jorge L Arredondo
Retrograde menstruation is common and in about 10% of women, endometrial tissues implant at ectopic sites and grow as endometriosis (EM) deposits. To date, there has been no marker to identify which patients have an endometrium that will generate deposits. Both endometrial regulatory T cells (Tregs) and increased stromal cell indoleamine 2,3-dioxygenase (IDO) have been implicated, and may suppress rejection by peritoneal NK cells, neutrophils, and cytotoxic macrophages. CD200 is a tolerance signaling molecule which promotes Tregs, IDO-producing macrophages, and can directly inhibit cytolytic natural killer (NK) cells and neutrophils...
May 21, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29803191/the-duration-of-sexual-relationship-and-its-effects-on-adverse-pregnancy-outcomes
#6
Prabha Andraweera, Claire T Roberts, Shalem Leemaqz, Lesley McCowan, Jenny Myers, Louise C Kenny, James Walker, Lucilla Poston, Gus Dekker
This study aims to determine if a short duration of sexual relationship is more common among women who experience adverse pregnancy outcomes including gestational hypertension (GHT), preeclampsia, small for gestational age (SGA) pregnancies and spontaneous preterm birth (sPTB) with or without abnormal uterine artery Doppler compared to women who have uncomplicated pregnancies. 5591 nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study were included. The risk for pregnancy complications for women who had a duration of sexual relationship of ≤3 months, 4-6 months, 7-9 months, 10-12 months was compared with women who had a duration of sexual relationship of >12 months...
May 18, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29778789/editorial-of-the-themed-issue-on-10th-workshop-on-immunology-of-preeclampsia
#7
EDITORIAL
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat
No abstract text is available yet for this article.
May 17, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29758486/poly-i-c-and-lps-induce-distinct-immune-responses-by-ovarian-stromal-fibroblasts
#8
Mickey V Patel, Zheng Shen, Charles R Wira
Despite its anatomical location, the ovary is a site of pathogen exposure in the human female reproductive tract (FRT). However, the role of ovarian stromal fibroblasts in immune protection is unclear. We generated a population of ovarian stromal fibroblasts derived from normal human ovaries that expressed the pattern recognition receptors TLR3, TLR4, RIG-I, & MDA5. Poly (I:C) and LPS, respective mimics of viral and bacterial infections, selectively upregulated antiviral gene expression and secretion of chemokines and antimicrobials...
May 9, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29751216/pellino-1-is-a-novel-regulator-of-tnf-and-tlr-signalling-in-human-myometrial-and-amnion-cells
#9
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators...
April 14, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29763854/inhibition-of-pregnancy-associated-granulocytic-myeloid-derived-suppressor-cell-expansion-and-arginase-1-production-in-preeclampsia
#10
Yinan Wang, Yanhou Liu, Chang Shu, Jiya Wan, Yanhong Shan, Xinyi Zhi, Liguang Sun, Huanfa Yi, Yong-Guang Yang, Jin He
Myeloid-derived suppressor cells (MDSCs) expand in maternal peripheral blood and cord blood during normal pregnancy to maintain maternal-fetal tolerance. Here we investigated the expansion and function of MDSCs in preeclampsia (PE) patients. Maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) were sampled from healthy pregnant women and PE patients, and analyzed for the frequencies and phenotypes of MDSCs and T cells. Serum levels of key human MDSC effector enzymes were measured using appropriate detection kits...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29758487/maternal-allergy-as-an-isolated-risk-factor-for-early-onset-preeclampsia-an-epidemiological-study
#11
Anne Kvie Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Nils-Halvdan Morken
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29689494/angiogenic-factors-in-pregnancies-of-women-with-antiphospholipid-syndrome-and-systemic-lupus-erythematosus
#12
Karoline Mayer-Pickel, Christina Stern, Katharina Eberhard, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
OBJECTIVES: An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy. MATERIAL AND METHODS: Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29656181/elevated-systemic-microbial-translocation-in-pregnant-hiv-infected-women-compared-to-hiv-uninfected-women-and-its-inverse-correlations-with-plasma-progesterone-levels
#13
Zejun Zhou, Anna Maya Powell, Vishwanathan Ramakrishnan, Allison Eckard, Carol Wagner, Wei Jiang
In HIV infection, increased adverse perinatal outcomes reported among HIV-associated pregnancies are not fully understood. Currently, microbial product translocation (MT) from a permeable mucosa is demonstrated as a driver of inflammation, and may contribute to preterm delivery in HIV. Here, our results showed that plasma LPS levels (a representative marker of MT) were increased in HIV-infected women in the first and second trimester. Progesterone levels were significantly decreased in HIV-infected subjects in the first trimester and second trimester...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29627619/impact-of-prednisone-in-patients-with-repeated-embryo-implantation-failures-beneficial-or-deleterious
#14
REVIEW
Nathalie Lédée, Laura Prat-Ellenberg, Marie Petitbarat, Lucie Chevrier, Cynthia Simon, Elie El Irani, Dominique Vitoux, Armand Bensussan, Gérard Chaouat
INTRODUCTION: Corticotherapy is the leading medication worldwide for patients with history of repeated implantation failures (RIF) after IVF/ICSI. Nevertheless, we still do not know its local mechanism of action, hence its precise indication. Our objective is to document the impact of prednisone on the endometrial expression of immune biomarkers (CD56 cells count, IL-18/TWEAK, IL-15/Fn-14 mRNA ratio) at the time of uterine receptivity in a RIF population. MATERIALS AND METHOD: An endometrial biopsy was realized in the mid luteal phase for immune profiling: IL-15/Fn-14 and IL-18/TWEAK mRNA ratios were determined by quantitative RT-PCR and CD56 mobilization per IHC...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29574310/high-serum-igf-1-levels-are-associated-with-pregnancy-loss-following-frozen-thawed-euploid-embryo-transfer-cycles
#15
Mohamad Irani, Dimitrios Nasioudis, Steven S Witkin, Vinay Gunnala, Steven D Spandorfer
An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid and thus reversed its deleterious effects on embryo development and increased the number of normal embryos. Therefore, we investigated whether serum levels of IGF-1 correlate with the incidence of pregnancy loss following IVF...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29571945/trophoblast-cd200-expression-in-successful-human-pregancies-and-missed-abortions
#16
David A Clark, M Elizabeth McCready, Kate Harris, Leslie Malloy, Jorge L Arredondo
Presence of the CD200 immune check-point inhibitor at the feto-maternal interface is linked to prevention of spontaneous abortion in mice and humans. In human missed abortions (MA), absence of Th17-driven inflammation has been attributed to expression of villus trophoblast CD200 quantified using immunohistochemistry. While rapid aneuploidy (QF-PCR) testing linked low CD200 to pregnancy failure, data showing normal VT CD200 in first trimester normal pregnancy and in abortion of chromosomally abnormal embryos has not been demonstrated...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29550618/first-trimester-enterovirus-igm-and-beta-cell-autoantibodies-in-mothers-to-children-affected-by-type-1-diabetes-autoimmunity-before-7-years-of-age
#17
Alexander Lind, Kristian F Lynch, Markus Lundgren, Åke Lernmark, Peter Almgren, Anita Ramelius, Leena Puustinen, Heikki Hyöty, Annika Lundstig
BACKGROUND: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. MATERIALS AND METHODS: Local registries were used to identify mothers to children born 2000-2007 who developed either beta cell autoantibodies or T1D during follow up...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29525428/circulating-pathogen-specific-plasmablasts-in-female-patients-with-upper-genital-tract-infection
#18
Nina V Palkola, Sari H Pakkanen, Oskari Heikinheimo, Jussi M Kantele, Anu Kantele
Mucosal antibodies constitute the first line of adaptive immune defence against invaders in the female genital tract (FGT), yet the sequence of events leading to their production is surprisingly poorly characterized. We explored the induction of pathogen-specific antibody-secreting cells (ASC) as a response to an acute infection in the upper FGT. We recruited 12 patients undergoing surgery due to an upper FGT infection (7/12 blood culture positive, 5/12 negative) and six healthy controls. Pathogens were sampled during surgery and PBMC collected in the acute phase of the disease (days 7-10)...
April 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29524791/polybacterial-stimulation-suggests-discrete-il-6-il-6r-signaling-in-human-fetal-membranes-potential-implications-on-il-6-bioactivity
#19
Nathalia Mayumi Noda-Nicolau, Jossimara Polettini, Márcia Guimarães da Silva, Morgan R Peltier, Ramkumar Menon
The polybacterial invasion of the amniotic cavity and risk of preterm birth is often due to cervicovaginal bacteria such as genital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and Gardnerella vaginalis. The most studied biomarker associated with preterm birth is interleukin-6 (IL-6), a pleiotropic cytokine that performs different functions based on classical or trans-signaling mechanisms. This study evaluated the changes in IL-6 and IL-6 function associated accessory molecules by human fetal membranes to determine the functional availability of IL-6 assessment in an in vitro model of polybacterial infection...
April 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29501895/immune-profile-in-relation-to-sex-steroid-cyclicity-in-healthy-women-and-women-with-multiple-sclerosis
#20
Per Kempe, Daniel Eklund, Agnes Hallin, Mats Hammar, Tomas Olsson, Jan Brynhildsen, Jan Ernerudh
To prospectively study systemic in vivo immunological effects of sex hormones, using different phases of oral combined hormonal contraceptives (CHC), and the natural menstrual cycles in both healthy women and in women with multiple sclerosis (MS), blood samples from sixty female MS patients and healthy controls with and without CHC were drawn in high and low estrogenic/progestogenic phases. Expression of Th-associated genes in blood cells was determined by qPCR and a panel of cytokines and chemokines was measured in plasma...
April 2018: Journal of Reproductive Immunology
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