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Journal of Reproductive Immunology

Laise Nayana Sala Elpidio, Josiane Bazzo de Alencar, Patrícia Yumeko Tsuneto, Hugo Vicentin Alves, Mariana Trento Toretta, Sérgio Ken It Taura, Jeane Eliete Laguila Visentainer, Ana Maria Sell
Polycystic ovary syndrome (PCOS) affects the endocrine system and is associated with low-grade inflammation. Natural killer (NK) cells are involved in the defense of the female reproductive tract, folliculogenesis, ovulation and the menstrual cycle. The killer-cell immunoglobulin-like receptors (KIR) on the surface of NK cells modulate the activation and function of these cells after interacting with human leukocyte antigen (HLA) class I ligands. The objective of this study was to evaluate the possible association of the KIR and their HLA ligands with polycystic ovary syndrome...
August 4, 2018: Journal of Reproductive Immunology
Magdalena Palacz, Kelton Tremellen
Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Significant positive correlations were observed between BMI and endometrial Treg cells and macrophages, but no relationship with NK cells...
August 4, 2018: Journal of Reproductive Immunology
Lia Karina Volpato, Verônica Vargas Horewicz, Franciane Bobinski, Daniel Fernandes Martins, Anna Paula Piovezan
To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1ß (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA)...
August 3, 2018: Journal of Reproductive Immunology
Agnes Jaeger-Lansky, Klara Schmidthaler, Lorenz Kuessel, Manuela Gstöttner, Petra Waidhofer-Söllner, Gerhard J Zlabinger, René Wenzl, Thomas Eiwegger
Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis...
July 25, 2018: Journal of Reproductive Immunology
Guro M Johnsen, Gro L Størvold, Jos J M Drabbels, Geert W Haasnoot, Michael Eikmans, Marijke J Spruyt-Gerritse, Patji Alnæs-Katjavivi, Sicco A Scherjon, Christopher W G Redman, Frans H J Claas, Anne Cathrine Staff
Acute atherosis is an arterial lesion most often occurring in pregnancies complicated by preeclampsia, a hypertensive pregnancy disorder. Acute atherosis predominates in the maternal spiral arteries in the decidua basalis layer of the pregnant uterus. This layer forms the fetal-maternal immunological interface, where fetal extravillous trophoblasts interact with maternal immune cells to promote decidual spiral artery remodeling and maternal immune tolerance towards the fetus. Of the classical polymorphic class I HLAs, extravillous trophoblasts express only HLA-C...
July 25, 2018: Journal of Reproductive Immunology
Asmaa M Zahran, Kamal M Zharan, Helal F Hetta
BACKGROUND AND AIM: Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Also, vitamin D is known to play a role in promoting the function of regulatory T-cells (Tregs). Tregs play an important role in suppressing the immune response during pregnancy. Our study aimed to investigate Tregs phenotypes in preterm and tem laboring women and its association with vitamin D level. METHODS: This cross-sectional study included 82 pregnant women, divided into 46 term and 36 preterm laboring women in addition to 30 healthy non-pregnant women...
July 17, 2018: Journal of Reproductive Immunology
Renate Von Linsingen, Geórgia Fernanda Gelmini, Maria da Graça Bicalho, Newton Sérgio De Carvalho
The aim of this case- control study was to investigate the association between preterm birth (PTB), MICA-129 A/G dimorphism and sMICA levels. Fifty pregnant women with singleton pregnancy and previous PTB, or clinic diagnostic of threatened preterm labor in the actual pregnancy, or cervical length less than 25 mm and 50 healthy pregnant women were enrolled. DNA was extracted for genotyping for MICA-129 A/G by real-time PCR and sMICA plasma level was quantified by sandwich ELISA assay. Clinical and socioeconomic characteristics, results of TaqMan® genotyping and ELISA quantification were compared between the groups using qui-square, Fisher´s exact or Mann-Whitney test...
July 10, 2018: Journal of Reproductive Immunology
Qinyang Xu, Fei Du, Ye Zhang, Yincheng Teng, Minfang Tao, Alex F Chen, Rongzhen Jiang
To explore new ideas about the pathogeny of preeclampsia (PE) proteinuria, this study focused on whether severe PE serum (PES) could induce high-molecular-weight protein (HMWP) hyperpermeability in glomerular endothelial cells (GEC) via the HMGB1-Caveolin-1 (CAV-1) pathway. Normal pregnancy serum (NPS) and severe PES were used to treat primary human GEC monolayer for 24 h. The CAV-1 inhibitor methyl-beta-cyclodextrin (MBCD), the HMGB1 inhibitor glycyrrhizicacid (GA), recombinant HMGB1 (rHMGB1) were also used to treat GEC monolayer that were stimulated by NPS or severe PES...
July 6, 2018: Journal of Reproductive Immunology
Alice Gilman-Sachs, Svetlana Dambaeva, Maria D Salazar Garcia, Youssef Hussein, Joanne Kwak-Kim, Kenneth Beaman
Preterm birth which occurs before 37 weeks gestation is one of the most common obstetrical complication in humans. After many studies, it appears that "not one answer fits all" regarding the risk factors, causes and the treatments for this syndrome. However, it is becoming more evident that one of the major risk factors is inflammation and/or infection in the fetoplacental unit. In animal models (usually consisting of mice injected with lipopolysaccharide at 14 days of gestation), IL-22 and IL-6 have been identified as factors related to preterm birth...
June 30, 2018: Journal of Reproductive Immunology
C Tersigni, C W Redman, R Dragovic, D Tannetta, G Scambia, N Di Simone, I Sargent, M Vatish
In normal pregnancy, villous cytotrophoblast and syncytiotrophoblast do not express HLA Class I and Class II molecules, while invasive extravillous trophoblast only express class I HLA-C and the atypical class Ib antigens, HLA-G, -E and -F. Inadequate maternal tolerance of invasive trophoblast has been proposed as a possible immunologic trigger of poor trophoblast invasion and subsequent occurrence of pre-eclampsia. This study aimed to investigate possible aberrant expression of class II HLA-DR on placentae and syncytiotrophoblast-derived extracellular vesicles (STEVs), obtained by dual placental perfusion, from pre-eclampsia (n = 23) and normal pregnant (n = 14) women...
June 19, 2018: Journal of Reproductive Immunology
Susanne Maria Ziegler, Cai Niklaas Feldmann, Sven Hendrik Hagen, Laura Richert, Tanja Barkhausen, Janina Goletzke, Virginija Jazbutyte, Gloria Martrus, Wilhelm Salzberger, Thomas Renné, Kurt Hecher, Anke Diemert, Petra Clara Arck, Marcus Altfeld
During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. In a longitudinal study of pregnant women, we investigated innate immune cell function in response to toll-like receptors (TLR) 4 and 7 stimulation, two TLR pathways playing a critical role in early innate immune recognition of bacteria and viruses...
May 24, 2018: Journal of Reproductive Immunology
Calliope Holingue, Jocelynn T Owusu, Kenneth A Feder, Adam P Spira
Pregnant women experience more sleep disturbances and greater systemic inflammation than non-pregnant women. However, the few studies that have examined the links between sleep and inflammation in pregnant women have been in clinical samples. We examined whether sleep duration is associated with C-reactive protein (CRP) levels, a marker of inflammation, in pregnant and non-pregnant women in a population-based sample of US women. Participants were 2865 women of reproductive age (aged 20-44 years) in the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of Americans...
May 23, 2018: Journal of Reproductive Immunology
Amalie Bjerke Rieber-Mohn, Meryam Sugulle, Gerd Wallukat, Patji Alnæs-Katjavivi, Gro Leite Størvold, Nils Bolstad, Christopher Wg Redman, Ralf Dechend, Anne Cathrine Staff
BACKGROUND: Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies at the angiotensin-II type 1 receptor (AT1 -AA) are increased in preeclampsia. We hypothesized an association between AT1 -AA at delivery and postpartum with acute atherosis in pregnancy...
May 22, 2018: Journal of Reproductive Immunology
Kaiyu Jiang, Laiping Wong, Yanmin Chen, Xiaoyun Xing, Daofeng Li, Ting Wang, James N Jarvis
The studies proposed here were undertaken to test the hypothesis that, under specific circumstances (e.g., a strong enough inflammatory stimulus), genes that are repressed at the maternal-fetal interface via DNA methylation might be de-methylated, allowing either a maternal immune response to the semi-allogenic fetus or the onset of early labor. Chorionic trophoblasts (CT) were isolated from fetal membranes, followed by incubation with medium from LPS-activated PBMC or resting PBMC medium for 2 h. RNA and DNA were isolated from the cells for RNA-seq and DNA methylation studies...
May 22, 2018: Journal of Reproductive Immunology
David A Clark, Jennifer M Dmetrichuk, Sukhbinder Dhesy-Thind, Mark A Crowther, Jorge L Arredondo
Retrograde menstruation is common and in about 10% of women, endometrial tissues implant at ectopic sites and grow as endometriosis (EM) deposits. To date, there has been no marker to identify which patients have an endometrium that will generate deposits. Both endometrial regulatory T cells (Tregs) and increased stromal cell indoleamine 2,3-dioxygenase (IDO) have been implicated, and may suppress rejection by peritoneal NK cells, neutrophils, and cytotoxic macrophages. CD200 is a tolerance signaling molecule which promotes Tregs, IDO-producing macrophages, and can directly inhibit cytolytic natural killer (NK) cells and neutrophils...
May 21, 2018: Journal of Reproductive Immunology
Yinan Wang, Yanhou Liu, Chang Shu, Jiya Wan, Yanhong Shan, Xinyi Zhi, Liguang Sun, Huanfa Yi, Yong-Guang Yang, Jin He
Myeloid-derived suppressor cells (MDSCs) expand in maternal peripheral blood and cord blood during normal pregnancy to maintain maternal-fetal tolerance. Here we investigated the expansion and function of MDSCs in preeclampsia (PE) patients. Maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) were sampled from healthy pregnant women and PE patients, and analyzed for the frequencies and phenotypes of MDSCs and T cells. Serum levels of key human MDSC effector enzymes were measured using appropriate detection kits...
June 2018: Journal of Reproductive Immunology
Anne Kvie Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Nils-Halvdan Morken
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system...
June 2018: Journal of Reproductive Immunology
Mickey V Patel, Zheng Shen, Charles R Wira
Despite its anatomical location, the ovary is a site of pathogen exposure in the human female reproductive tract (FRT). However, the role of ovarian stromal fibroblasts in immune protection is unclear. We generated a population of ovarian stromal fibroblasts derived from normal human ovaries that expressed the pattern recognition receptors TLR3, TLR4, RIG-I, & MDA5. Poly (I:C) and LPS, respective mimics of viral and bacterial infections, selectively upregulated antiviral gene expression and secretion of chemokines and antimicrobials...
June 2018: Journal of Reproductive Immunology
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators...
June 2018: Journal of Reproductive Immunology
Karoline Mayer-Pickel, Christina Stern, Katharina Eberhard, Uwe Lang, Barbara Obermayer-Pietsch, Mila Cervar-Zivkovic
OBJECTIVES: An imbalance of angiogenic placental factors such as endoglin, soluble fms-like tyrosine kinase 1(sFlt-1) and placental growth factor (PlGF) has been implicated in the pathophysiology of preeclampsia. This study aimed to evaluate serum levels of sFlt-1, PlGF and endoglin in women with primary and secondary antiphospholipid Syndrome (APS) and systemic lupus erythematosus (SLE) longitudinally through pregnancy. MATERIAL AND METHODS: Serum levels of sFlt-1, PlGF and endoglin were measured prospectively at 4-week intervals (from gestational weeks 12-36) in 17 women with primary APS (PAPS), 18 women with secondary APS (SAPS), and 23 women with SLE...
June 2018: Journal of Reproductive Immunology
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