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Journal of Reproductive Immunology

Mark Hedger, Nicolette A Hodyl, Timothy J Moss
No abstract text is available yet for this article.
September 27, 2018: Journal of Reproductive Immunology
Nathalie Lédée, Claudine Vasseur, Marie Petitbarat, Lucie Chevrier, Katia Vezmar, Geraldine Dray, Sandra Chenière, Annina Lobersztajn, Dominique Vitoux, Guy Nino Cassuto, Gérard Chaouat
PROBLEM: Continuous failures to achieve a pregnancy despite effective embryo transfers is extremely distressing for couples. In consequence, many adjuvant therapies to IVF have been proposed to achieve an "ideal" immune environment. We here focus on Intralipid® therapy (IL) reported to have immunosuppressive properties on NK cells. METHOD OF STUDY: 94 patients exhibited an immune profile of endometrial over-immune activation and an history of repeated implantation failures despite multiple embryos transfers (RIF)...
September 24, 2018: Journal of Reproductive Immunology
Macarena B Gonzalez, Michelle Lane, Emma J Knight, Rebecca L Robker
The detrimental consequences of obesity on female fertility are well known, but the functional changes that occur in the ovary in response to elevated BMI are not clear. Obesity induces multiple components of a systemic inflammatory state that is a key pathway by which it initiates tissue dysfunction in adipose, liver and muscle; however whether obesity induces similar inflammatory changes in the ovary has not been fully investigated. This is important to understand because it is increasingly clear that obesity at conception impacts not only pregnancy rates but also influences pre-implantation embryo development...
August 22, 2018: Journal of Reproductive Immunology
M C Molenaar, M Singer, S Ouburg
Sexually transmitted infections (STI) can have major consequences for the reproductive health of women. Mycoplasma genitalium is a STI that is not as well studied but causes pelvic inflammatory disease (PID) among other complications. Another well-known STI is Chlamydia trachomatis, notorious for its capability to cause infertility. Both C. trachomatis and M. genitalium share some of the same clinical aspects. Parts of the pathogenesis of C. trachomatis and M. genitalium infections are unclear but potential factors are the microbiome and other STIs...
August 22, 2018: Journal of Reproductive Immunology
Laise Nayana Sala Elpidio, Josiane Bazzo de Alencar, Patrícia Yumeko Tsuneto, Hugo Vicentin Alves, Mariana Trento Toretta, Sérgio Ken It Taura, Jeane Eliete Laguila Visentainer, Ana Maria Sell
Polycystic ovary syndrome (PCOS) affects the endocrine system and is associated with low-grade inflammation. Natural killer (NK) cells are involved in the defense of the female reproductive tract, folliculogenesis, ovulation and the menstrual cycle. The killer-cell immunoglobulin-like receptors (KIR) on the surface of NK cells modulate the activation and function of these cells after interacting with human leukocyte antigen (HLA) class I ligands. The objective of this study was to evaluate the possible association of the KIR and their HLA ligands with polycystic ovary syndrome...
August 4, 2018: Journal of Reproductive Immunology
Magdalena Palacz, Kelton Tremellen
Obesity is associated with implantation failure, miscarriage, low-grade inflammation and a reduction in peripheral immune-suppressive T regulatory (Treg) cells. Therefore, we postulated that this reduction may also extend to the endometrium and cause embryonic loss. In a cohort of 40 infertile women, without implantation failure or recurrent miscarriage, we examined the density of Treg cells, macrophages and natural killer (NK) cells in mid-luteal endometrial biopsies. Significant positive correlations were observed between BMI and endometrial Treg cells and macrophages, but no relationship with NK cells...
September 2018: Journal of Reproductive Immunology
Agnes Jaeger-Lansky, Klara Schmidthaler, Lorenz Kuessel, Manuela Gstöttner, Petra Waidhofer-Söllner, Gerhard J Zlabinger, René Wenzl, Thomas Eiwegger
Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis...
July 25, 2018: Journal of Reproductive Immunology
Guro M Johnsen, Gro L Størvold, Jos J M Drabbels, Geert W Haasnoot, Michael Eikmans, Marijke J Spruyt-Gerritse, Patji Alnæs-Katjavivi, Sicco A Scherjon, Christopher W G Redman, Frans H J Claas, Anne Cathrine Staff
Acute atherosis is an arterial lesion most often occurring in pregnancies complicated by preeclampsia, a hypertensive pregnancy disorder. Acute atherosis predominates in the maternal spiral arteries in the decidua basalis layer of the pregnant uterus. This layer forms the fetal-maternal immunological interface, where fetal extravillous trophoblasts interact with maternal immune cells to promote decidual spiral artery remodeling and maternal immune tolerance towards the fetus. Of the classical polymorphic class I HLAs, extravillous trophoblasts express only HLA-C...
July 25, 2018: Journal of Reproductive Immunology
Akrem Abdulsid, Fiona Lyall
No abstract text is available yet for this article.
September 2018: Journal of Reproductive Immunology
K B Ziegler, D O Muzzio, F Matzner, I Bommer, M S Ventimiglia, K Malinowsky, J Ehrhardt, M Zygmunt, F Jensen
Though human pregnancy success has been classically linked with a shift into a Th2 immunoglobulin producing cell response, a clear picture concerning B cell development and immunoglobulin profile during human pregnancy is missing. We analyzed in this work the dynamic of different B cell populations in peripheral blood of pregnant women on the first, second and third trimester of pregnancy. As control, age-matched non-pregnant fertile women were included. Additionally, we quantified the levels of immunoglobulin (IgG1, IgG2, IgG3, IgG4, IgM, IgA and IgE) in the serum of pregnant and non-pregnant women...
September 2018: Journal of Reproductive Immunology
Lia Karina Volpato, Verônica Vargas Horewicz, Franciane Bobinski, Daniel Fernandes Martins, Anna Paula Piovezan
To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1ß (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA)...
September 2018: Journal of Reproductive Immunology
Susanne Maria Ziegler, Cai Niklaas Feldmann, Sven Hendrik Hagen, Laura Richert, Tanja Barkhausen, Janina Goletzke, Virginija Jazbutyte, Gloria Martrus, Wilhelm Salzberger, Thomas Renné, Kurt Hecher, Anke Diemert, Petra Clara Arck, Marcus Altfeld
During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. In a longitudinal study of pregnant women, we investigated innate immune cell function in response to toll-like receptors (TLR) 4 and 7 stimulation, two TLR pathways playing a critical role in early innate immune recognition of bacteria and viruses...
August 2018: Journal of Reproductive Immunology
Amalie Bjerke Rieber-Mohn, Meryam Sugulle, Gerd Wallukat, Patji Alnæs-Katjavivi, Gro Leite Størvold, Nils Bolstad, Christopher Wg Redman, Ralf Dechend, Anne Cathrine Staff
BACKGROUND: Uteroplacental acute atherosis is a pregnancy-specific lesion resembling early stages of atherosclerosis found frequently in preeclampsia. Preeclampsia is associated with an increased risk for future maternal atherosclerotic cardiovascular disease. The renin-angiotensin-system plays a role both in atherosclerosis and in preeclampsia. Circulating agonistic autoantibodies at the angiotensin-II type 1 receptor (AT1 -AA) are increased in preeclampsia. We hypothesized an association between AT1 -AA at delivery and postpartum with acute atherosis in pregnancy...
August 2018: Journal of Reproductive Immunology
Calliope Holingue, Jocelynn T Owusu, Kenneth A Feder, Adam P Spira
Pregnant women experience more sleep disturbances and greater systemic inflammation than non-pregnant women. However, the few studies that have examined the links between sleep and inflammation in pregnant women have been in clinical samples. We examined whether sleep duration is associated with C-reactive protein (CRP) levels, a marker of inflammation, in pregnant and non-pregnant women in a population-based sample of US women. Participants were 2865 women of reproductive age (aged 20-44 years) in the National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of Americans...
August 2018: Journal of Reproductive Immunology
Prabha Andraweera, Claire T Roberts, Shalem Leemaqz, Lesley McCowan, Jenny Myers, Louise C Kenny, James Walker, Lucilla Poston, Gus Dekker
This study aims to determine if a short duration of sexual relationship is more common among women who experience adverse pregnancy outcomes including gestational hypertension (GHT), preeclampsia, small for gestational age (SGA) pregnancies and spontaneous preterm birth (sPTB) with or without abnormal uterine artery Doppler compared to women who have uncomplicated pregnancies. 5591 nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study were included. The risk for pregnancy complications for women who had a duration of sexual relationship of ≤3 months, 4-6 months, 7-9 months, 10-12 months was compared with women who had a duration of sexual relationship of >12 months...
August 2018: Journal of Reproductive Immunology
Kaiyu Jiang, Laiping Wong, Yanmin Chen, Xiaoyun Xing, Daofeng Li, Ting Wang, James N Jarvis
The studies proposed here were undertaken to test the hypothesis that, under specific circumstances (e.g., a strong enough inflammatory stimulus), genes that are repressed at the maternal-fetal interface via DNA methylation might be de-methylated, allowing either a maternal immune response to the semi-allogenic fetus or the onset of early labor. Chorionic trophoblasts (CT) were isolated from fetal membranes, followed by incubation with medium from LPS-activated PBMC or resting PBMC medium for 2 h. RNA and DNA were isolated from the cells for RNA-seq and DNA methylation studies...
August 2018: Journal of Reproductive Immunology
Pierre-Yves Robillard, Gustaaf Dekker, Gérard Chaouat
No abstract text is available yet for this article.
August 2018: Journal of Reproductive Immunology
Asmaa M Zahran, Kamal M Zharan, Helal F Hetta
BACKGROUND AND AIM: Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Also, vitamin D is known to play a role in promoting the function of regulatory T-cells (Tregs). Tregs play an important role in suppressing the immune response during pregnancy. Our study aimed to investigate Tregs phenotypes in preterm and tem laboring women and its association with vitamin D level. METHODS: This cross-sectional study included 82 pregnant women, divided into 46 term and 36 preterm laboring women in addition to 30 healthy non-pregnant women...
July 17, 2018: Journal of Reproductive Immunology
Renate Von Linsingen, Geórgia Fernanda Gelmini, Maria da Graça Bicalho, Newton Sérgio De Carvalho
The aim of this case- control study was to investigate the association between preterm birth (PTB), MICA-129 A/G dimorphism and sMICA levels. Fifty pregnant women with singleton pregnancy and previous PTB, or clinic diagnostic of threatened preterm labor in the actual pregnancy, or cervical length less than 25 mm and 50 healthy pregnant women were enrolled. DNA was extracted for genotyping for MICA-129 A/G by real-time PCR and sMICA plasma level was quantified by sandwich ELISA assay. Clinical and socioeconomic characteristics, results of TaqMan® genotyping and ELISA quantification were compared between the groups using qui-square, Fisher´s exact or Mann-Whitney test...
July 10, 2018: Journal of Reproductive Immunology
Qinyang Xu, Fei Du, Ye Zhang, Yincheng Teng, Minfang Tao, Alex F Chen, Rongzhen Jiang
To explore new ideas about the pathogeny of preeclampsia (PE) proteinuria, this study focused on whether severe PE serum (PES) could induce high-molecular-weight protein (HMWP) hyperpermeability in glomerular endothelial cells (GEC) via the HMGB1-Caveolin-1 (CAV-1) pathway. Normal pregnancy serum (NPS) and severe PES were used to treat primary human GEC monolayer for 24 h. The CAV-1 inhibitor methyl-beta-cyclodextrin (MBCD), the HMGB1 inhibitor glycyrrhizicacid (GA), recombinant HMGB1 (rHMGB1) were also used to treat GEC monolayer that were stimulated by NPS or severe PES...
July 6, 2018: Journal of Reproductive Immunology
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