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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/30218143/melanoma-prone-families-new-evidence-of-distinctive-clinical-and-histological-features-of-melanomas-in-cdkn2a-mutation-carriers
#1
Laura Cristina Gironi, Enrico Colombo, Barbara Pasini, Roberto Giorgione, Pamela Farinelli, Francesca Zottarelli, Elia Esposto, Elisa Zavattaro, Elias Allara, Paola Ogliara, Marta Betti, Irma Dianzani, Paola Savoia
Germline mutations on the CDKN2A gene, the most important known genetic factors associated with cutaneous melanomas (CMs), predispose carriers to multiple primary CMs (MPMs) with higher frequency and younger onset compared to non-carriers. Most of the largest published studies concerning clinical and histological characteristics of CMs with CDKN2A mutation carriers did not specify if the described CMs are first or subsequent to the first, and they used sporadic CMs from non-genotyped patients as controls. We conducted a single-centre observational study to compare clinical and histological CM features of 32 unrelated carriers (MUT) of 5 germline CDKN2A mutations (one of which was never previously described) compared to 100 genotyped wild-type (WT) patients...
September 15, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30209581/decreased-expression-of-g-protein-coupled-receptors-gpr43-and-gpr109a-in-psoriatic-skin-can-be-restored-by-topical-application-of-sodium-butyrate
#2
Alicja Krejner, Anika Bruhs, Ulrich Mrowietz, Ulrike Wehkamp, Thomas Schwarz, Agatha Schwarz
The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of these receptors and their reaction to SB in psoriasis. Lesional and non-lesional biopsies of 6 psoriasis patients and of 4 controls were obtained and stained for GPR109a and GPR43...
September 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30209580/the-role-of-trka-in-the-promoting-wounding-healing-effect-of-cd271-on-epidermal-stem-cells
#3
Min Zhang, Yuehou Zhang, Jun Ding, Xiaohong Li, Chengyu Zang, Siyuan Yin, Jiaxu Ma, Yibing Wang, Yongqian Cao
CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exact role of TrkA combined with CD271 in eSCs during skin wound closure is still unclear. This study aimed to reveal the role of TrkA in the promoting wounding-healing effect of CD271 on eSCs. We obtained CD271-vo (over-expression of CD271) eSCs by lentiviral infection...
September 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30182275/age-related-and-seasonal-changes-in-covalently-bound-ceramide-content-in-forearm-stratum-corneum-of-japanese-subjects-determination-of-molecular-species-of-ceramides
#4
Anna Fujiwara, Masashi Morifuji, Masami Kitade, Keiko Kawahata, Tomoyuki Fukasawa, Taketo Yamaji, Hiroyuki Itoh, Makoto Kawashima
The stratum corneum (SC) consists of corneocytes surrounded by a neutral lipid-enriched intercellular matrix. Ceramides represent approximately 50% of intercellular lipids, and play important roles in retaining epidermal water. The SC also contains covalently bound ceramides, which are thought to play a crucial role in the formation of lamellar structures, and are involved in maintaining skin barrier function. A previous report showed that levels of free ceramides in human SC changed with the seasons and age, although whether the content of different species of covalently bound ceramides also underwent such temporal changes was unclear...
September 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30171347/comprehensive-assessment-of-the-association-between-genes-on-jak-stat-pathway-ifih1-tyk2-il-10-and-systemic-lupus-erythematosus-a-meta-analysis
#5
Qiong Yin, Liang-Cai Wu, Lu Zheng, Ming-Yu Han, Li-Ya Hu, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jiang-Wei Xia, Xiao-Bo Wang, Xing-Wei Zhang, Hou-Feng Zheng
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2...
August 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167816/complex-segregation-analysis-of-facial-melasma-in-brazil-evidence-for-a-genetic-susceptibility-with-a-dominant-pattern-of-segregation
#6
Nicole França Holmo, Geovana Brotto Ramos, Heloisa Salomão, Renata Iani Werneck, Marcelo Távora Mira, Luciane Donida Bartoli Miot, Hélio Amante Miot
Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40-60%) suggests a genetic predisposition to the disease. This study explored, through complex segregation analysis (CSA), the inheritance model that best fit the family segregation pattern of facial melasma when accounting for the main epidemiological risk factors...
August 30, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167813/a-comprehensive-in-vivo-study-of-caucasian-facial-skin-parameters-on-442-women
#7
Lenka Machková, Daniel Švadlák, Iva Dolečková
Generally, skin properties are highly specific for each individual depending on various factors such as genetic predisposition, age, gender, body region, health and lifestyle. In this study, we measured various skin parameters on forehead, temple and cheek of 442 Caucasian women between 23 and 63 years, and evaluated differences between these facial regions and also the relationship between skin parameters and age of the volunteers. We measured transepidermal water loss (TEWL), stratum corneum hydration, skin gloss, melanin level, individual typology angle (ITA), erythema, sebum level and elasticity (R7)...
August 30, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30151656/the-investigation-of-the-relationships-of-demodex-density-with-inflammatory-response-and-oxidative-stress-in-rosacea
#8
Tuğba Falay Gur, Aslı Vefa Erdemir, Mehmet Salih Gurel, Abdurrahim Kocyigit, Eray Metin Guler, Duygu Erdil
The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis...
August 27, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167814/achieving-international-consensus-on-the-assessment-of-psoriatic-arthritis-in-psoriasis-clinical-trials-an-international-dermatology-outcome-measures-ideom-initiative
#9
Lourdes Maria Perez-Chada, Jeffrey M Cohen, Alice Bendix Gottlieb, Kristina Callis Duffin, Amit Garg, John Latella, April Wang Armstrong, Alexis Ogdie, Joseph Frank Merola
Psoriatic arthritis (PsA) is rarely assessed in psoriasis randomized controlled trials (RCT); thus, the effect of psoriasis therapy on PsA is unknown. The International Dermatology Outcome Measures (IDEOM) has included "PsA Symptoms" as part of the core domains to be measured in psoriasis RCT. This study aimed to achieve consensus about screening for PsA and how to measure for "PsA Symptoms" in psoriasis RCT. At the IDEOM 2017 Annual Meeting, stakeholders voted on the role of PsA screening in psoriasis RCT...
August 25, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29995261/linoleate-enriched-diet-increases-both-linoleic-acid-esterified-to-omega-hydroxy-very-long-chain-fatty-acids-and-free-ceramides-of-canine-stratum-corneum-without-effect-on-protein-bound-ceramides-and-skin-barrier-function
#10
Iuliana Popa, Adrian L Watson, Audrey Solgadi, Christina Butowski, David Allaway, Jacques Portoukalian
Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was studied by feeding two groups of five dogs differential amounts of linoleic acid (LA) for three months. SC was harvested by tape stripping and lipids were analyzed by thin-layer chromatography and mass spectrometry. The dogs that were fed the higher concentration of LA showed high increases in the contents of both linoleic acid and free ceramides in the SC, whereas the protein-bound ceramide content was unchanged...
July 11, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29934781/how-to-weight-patient-relevant-treatment-goals-for-assessing-treatment-benefit-in-psoriasis-preference-elicitation-methods-vs-rating-scales
#11
Mandy Gutknecht, Marthe-Lisa Schaarschmidt, Marion Danner, Marina Otten, Matthias Augustin
In psoriasis, several patient-relevant treatment goals must be met to be able to consider a treatment beneficial. To assess treatment benefit, the validated questionnaire Patient Benefit Index (PBI) can be used. Its global score summarizes the degree of patient-relevant treatment goals achieved after treatment, weighted by their individual importance on rating scales. These treatment goals have empirically been assigned to five dimensions. While the weighting procedure of the PBI provides information about the importance patients attach to treatment goals on a rating scale from 0 to 4, methods of preference elicitation provide information on how patients would trade off certain treatment goals against each other...
June 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29931443/identification-of-a-novel-mutation-in-the-mechanoreceptor-encoding-gene-cxcr1-in-patients-with-keloid
#12
Qiguo Zhang, Liangqi Cai, Mian Wang, Xiaoping Ke, Xiaoyan Zhao, Yijin Huang
Keloids are skin fibroproliferative tumors characterized by locally invasive growth of fibroblasts and excessive collagen deposition. The objective of this study is to investigate the molecular basis of the keloid scar by studying the mutation of related genes. We performed gene screening of mechanoreceptors by quantitative polymerase chain reaction (qPCR), Sanger sequencing to detect the CXCR1gene mutation, and immuno-histochemistry to determine CXCR1 protein expression. Among the genes encoding mechanoreceptors, the expression of CXCR1 mRNA was significantly higher in keloid scar tissues than in the surrounding tissues of normal controls (P < 0...
June 21, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167815/expression-of-inflammatory-and-fibrogenetic-markers-in-acne-hypertrophic-scar-formation-focusing-on-role-of-tgf-%C3%AE-and-igf-1r
#13
Ji Hoon Yang, Ji Young Yoon, Jungyoon Moon, Seonguk Min, Hyuck Hoon Kwon, Dae Hun Suh
Acne vulgaris is a universal skin disease and it may leave a scar when the original skin lesion disappears. These scars can cause cosmetic problems and psychological burden, leading to poor quality of life of patients. Acne scars are classified into atrophic scars and hypertrophic scars. As most of the acne scars are atrophic, many studies have been conducted focusing on the treatment of atrophic lesions. This study was conducted to investigate the underlying pathogenesis of acne hypertrophic scars by identifying roles of fibrogenetic and inflammatory markers...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30121698/efficacy-and-safety-of-secukinumab-treatment-in-adults-with-extensive-alopecia-areata
#14
Emma Guttman-Yassky, John K Nia, Peter W Hashim, Yasaman Mansouri, Erisa Alia, Mark Taliercio, Parth N Desai, Mark G Lebwohl
Alopecia areata (AA) is a common form of non-scarring hair loss. The pathogenesis of AA is believed to involve multiple inflammatory cytokines, including possibly IL-17A. To assess the efficacy and safety of the IL-17A antagonist secukinumab in AA, we conducted a double-blinded, randomized prospective pilot study in which 11 subjects were treated with either secukinumab (n = 7) or placebo (n = 4) subcutaneously at weeks 0, 1, 2, 3, 4 and every 4 weeks thereafter until (inclusive of) week 20. The primary endpoint for the study was the percentage of patients achieving SALT50 at 24 weeks...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30105449/caffeine-delivery-in-porcine-skin-a-confocal-raman-study
#15
Cristina Alonso, V Carrer, C Barba, L Coderch
Confocal Raman microscopy is a novel optical method for studies of pro-drug and drug delivery. This method is a promising technique that enables non-destructive measurement of the permeation profile through skin layers. Peaks of compounds are usually normalised to skin peaks (amino-acid and amide I) for semi-quantitative evaluation. The present study seeks to optimise a methodology for complete quantitative measurement of the amount of an active compound at different depths. Caffeine was used as a tracer to evaluate compound's skin penetration using confocal Raman microscopy...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30105448/heme-oxygenase-and-iron-status-in-exosomes-of-psoriasis-patients
#16
Abdel-Aziz A El-Rifaie, Dina Sabry, Reham W Doss, Mai A Kamal, Dalia M Abd El Hassib
Psoriasis is an autoimmune skin disease characterized by hyperproliferation of keratinocytes due to interplay between keratinocytes and immune cells. Iron status plays an important role in modifying the function of the immune system. Heme oxygenase (HO), heme-degrading enzyme, plays important role in protective response to oxidative cellular stress. We aimed in this study to map the iron status and HO levels and declare the role HO enzyme in iron homeostasis and immune-modulation in psoriasis. Fifty-one patients with psoriasis and 50 age- and sex-matched healthy controls were enrolled in this study...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30099574/different-trypanosoma-cruzi-calreticulin-domains-mediate-migration-and-proliferation-of-fibroblasts-in-vitro-and-skin-wound-healing-in-vivo
#17
Jose Ignacio Arias, Natalia Parra, Carolina Beato, Cristian Gabriel Torres, Christopher Hamilton-West, Carlos Rosas, Arturo Ferreira
Calreticulin is an endoplasmic reticulum-resident, calcium-binding, stress-produced, chaperone protein that serves multiple functions and is widely distributed in eukaryotic cells. Exogenously applied recombinant calreticulin solution, markedly enhanced the rate and quality of skin wound healing. These modulatory effects are more efficient than commercially available topic platelet-derived growth factor ointments (Regranex® ). Trypanosoma cruzi calreticulin is more effective in equimolar terms to human counterpart in accelerating skin wound healing...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30046896/glucosamine-abrogates-the-stem-cell-factor-endothelin-1-induced-stimulation-of-melanogenesis-via-a-deficiency-in-mitf-expression-due-to-the-proteolytic-degradation-of-creb-in-human-melanocytes
#18
Takao Niwano, Shuko Terazawa, Yoriko Sato, Takahiro Kato, Hiroaki Nakajima, Genji Imokawa
We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of GlcN using normal human melanocytes (NHMs) in culture. The SE-stimulated gene (12 h) and protein (24 h) expression levels of melanocyte-specific proteins (at the indicated times post-stimulation) were significantly abrogated by pretreatment with GlcN for 72 h...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30046895/ly2109761-reduces-tgf-%C3%AE-1-induced-collagen-production-and-contraction-in-hypertrophic-scar-fibroblasts
#19
Guo Wei, Qingqing Xu, Lin Liu, Huanhuan Zhang, Xi Tan, Chunhong Zhang, Changyu Han, Yanxia Guo, Ganwen Han, Chunmin Zhang
Hypertrophic scars (HS) are fibro-hyperproliferative dermal lesions with effusive continuous accumulation of extracellular matrix components, particularly collagen. They usually occur after dermal injury in genetically susceptible individuals and cause both physical and psychological distress for the affected individuals. Transforming growth factor-β1 (TGF-β1) is known to mediate wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation. The sustained high expression of TGF-β1 is believed to result in the formation of hypertrophic scars...
October 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29974194/phenotype-variability-in-tumor-disorders-of-the-skin-appendages-associated-with-mutations-in-the-cyld-gene
#20
Lizelotte J M T Parren, Kathrin Giehl, Michel van Geel, Jorge Frank
Mutations in the tumor suppressor gene CYLD underlie phenotypically heterogeneous hereditary tumor disorders of the skin appendages. These diseases are inherited autosomal dominantly and include Brooke-Spiegler syndrome (BSS; OMIM 605041), familial cylindromatosis (FC; OMIM 132700) and multiple familial trichoepithelioma (MFT; OMIM 601606). Clinically, cylindromas, trichoepitheliomas and spiradenomas can be found in affected individuals. We sought to elucidate the molecular genetic basis in individuals with newly diagnosed cylindromas, trichoepitheliomas and/or spiradenomas...
September 2018: Archives of Dermatological Research
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