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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/29330632/inate-immunity-in-rosacea-langerhans-cells-plasmacytoid-dentritic-cells-toll-like-receptors-and-inducible-oxide-nitric-synthase-inos-expression-in-skin-specimens-case-control-study
#1
Ana Karina Alves Moura, Fernanda Guedes, Maria Cecília Rivitti-Machado, Mirian N Sotto
Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Recent studies have suggested that aberrant innate immunity is central to this disease. The aim of this study was to examine the presence of Langerhans cells, plasmacytoid dentritic cells (PDC), the expression of Toll-like receptors (TLR) and inducible oxide nitric synthase (iNOS) in skin of patients with rosacea, to highlight the participation of innate immunity in its pathogenesis...
January 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29255925/increased-senescent-cd8-t-cells-in-the-peripheral-blood-mononuclear-cells-of-beh%C3%A3-et-s-disease-patients
#2
Ji Young Yang, Mi Jin Park, Sun Park, Eun-So Lee
Behçet's disease (BD) is a chronic inflammatory disease characterized by recurrent mucocutaneous, ocular, and skin lesions. Immunosenescence is associated with increased susceptibility to infection and chronic low grade inflammation. This study aimed to investigate the differences in the frequencies of immunosenescent cells in the peripheral blood mononuclear cells (PBMCs) of patients with BD. PBMCs were isolated from age-matched patients with active BD (n = 19), inactive BD (n = 20), disease controls (DCs, n = 15) and healthy controls (HCs, n = 15)...
December 18, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29214350/co-culture-of-human-fibroblasts-and-borrelia-burgdorferi-enhances-collagen-and-growth-factor-mrna
#3
Elisabeth Aberer, Milana Surtov-Pudar, Daniel Wilfinger, Alexander Deutsch, Gerd Leitinger, Helmut Schaider
Skin fibrosis has been reported in Borrelia burgdorferi infection in Europe, but has been questioned by several authors. The objective of the present study was to examine the interaction of skin fibroblasts with B. burgdorferi sensu stricto B31 (BB) and B. afzelii (BA) in vitro by electron microscopy. We also determined the expression of collagen type I, TGF-β, FGF-1, calreticulin (CALR), decorin (DCN), and PDGF-α at the mRNA level in Borrelia/fibroblast co-cultures. Intact Borrelia attach to and transmigrate fibroblasts, and undergo cystic transformation outside the fibroblasts...
December 6, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29204684/dna-methylation-of-the-cdc2l1-gene-promoter-region-decreases-the-expression-of-the-cdk11p58-protein-and-reduces-apoptosis-in-keloid-fibroblasts
#4
Gang Zhang, QiaoYu Guan, Guizong Chen, Fang Qian, Jie Liang
The excessive growth of fibroblasts in keloid is closely related to the status of gene methylation. The aim of this project was to study whether keloid development is related to DNA methylation in the CDC2L1 gene promoter region. DNA methylation of the promoter of this gene was analyzed by bisulfite sequencing and verified by DNA methylation-specific polymerase chain reaction. The results showed that the DNA methylation rate of CpG islands in the CDC2L1 gene promoter region was 50.0% (12/24) in patient keloid tissues and 0% (0/24) in normal skin-tissues from healthy controls...
December 4, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29181579/mediterranean-diet-fresh-herbs-and-fresh-vegetables-decrease-the-risk-of-androgenetic-alopecia-in-males
#5
Cristina Fortes, S Mastroeni, T Mannooranparampil, D Abeni, A Panebianco
It is well established that Androgenetic Alopecia (AGA) occurs in genetically predisposed individuals but little is known of its non-genetic risk factors. The aim of the study was to investigate the role of the Mediterranean diet in determining the risk of AGA. A hospital-based case-control study was conducted in the outpatient clinics of the hospital "Istituto Dermopatico dell'Immacolata, Rome, Italy". We included 104 males and 108 controls not affected by AGA. Controls were frequency matched to cases. Information on socio-demographic characteristics, medical history, smoking and diet were collected for all patients...
November 27, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29177757/the-role-of-dermoscopy-in-the-diagnosis-of-distal-lateral-subungual-onychomycosis
#6
Emre Kaynak, Fatih Göktay, Pembegül Güneş, Elif Sayman, Deniz Turan, Arzu Baygül, Sema Aytekin
Recently dermoscopic patterns, that can be useful in the diagnosis of distal and lateral subungual onychomycosis, were identified. In this study, we aimed to determine the frequency of the defined patterns so far and additionally to identify other patterns that were observed and to investigate the place of these patterns in the diagnosis of Distal Lateral Subungual Onychomycosis (DLSO) in the dermoscopic examination of the patients with pre-diagnosis of DLSO. Patients admitted dermatology outpatient clinic of Haydarpasa Numune Training and Research Hospital with the complaint of nail disturbance suspicious for DLSO (97 patients) between the August 2015 and February 2016...
November 24, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29147769/skin-barrier-and-microbiome-in-acne
#7
REVIEW
M A Rocha, E Bagatin
Acne is an immune-mediated chronic inflammatory disease. Although several factors are involved in its pathophysiology, this process is not completely understood. Androgen hormone activity increases sebum production inside the pilosebaceous follicle, adjusting the environment for the development of Propionibacterium acnes which triggers inflammation. Knowing how others factors such as the skin barrier and microbiome are involved in acne, can help in understanding more about the disease and may help to conduct a better treatment...
November 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29128966/is-the-dlqi-appropriate-for-medical-decision-making-in-psoriasis-patients
#8
Adrienn Katalin Poór, Valentin Brodszky, Márta Péntek, László Gulácsi, Gábor Ruzsa, Bernadett Hidvégi, Péter Holló, Sarolta Kárpáti, Miklós Sárdy, Fanni Rencz
Dermatology Life Quality Index (DLQI) is the most commonly applied measure of health-related quality of life (HRQoL) in psoriasis patients. It is among defining criteria of moderate-to-severe psoriasis and present in treatment guidelines. Our objective was to estimate preference-based HRQoL values (i.e., utilities) for hypothetical health states described by the 10 items of the DLQI in psoriasis patients. Moreover, we compare results to findings of a similar study previously conducted among the general public...
November 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29127481/expression-of-janus-kinase-1-in-vitiligo-psoriasis-before-and-after-narrow-band-uvb-a-case-control-study
#9
Hanan Rabea Nada, Dina Ahmed El Sharkawy, Maha Fathy Elmasry, Laila Ahmed Rashed, Sally Mamdouh
Janus kinases (JAKs) are non-receptor protein tyrosine kinases that are expressed in many tissues. Once the JAKs are activated, a cascade of further signaling events is triggered involving phosphorylation of selected receptor chain tyrosines, binding of signal transducer and activator of transcription (STAT) proteins and phosphorylation of these STATs. Due to their ability to selectively modulate immune function, targeted JAK inhibitors are promising candidates for some skin diseases such as psoriasis and atopic dermatitis...
November 10, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29127480/quality-assessment-of-atopic-dermatitis-clinical-practice-guidelines-in-%C3%A2-%C3%A2-18-years
#10
Luz de María Díaz Granados, María Adelaida Quijano, Paola Andrea Ramírez, Natalia Aguirre, Gloria Sanclemente
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatment options for this condition including topical and systemic regimes. The decision to choose a treatment option in dermatological diseases is greatly influenced by the personal experience of each specialist, which increases variability in the selection of available therapies...
November 10, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29119273/immunohistochemical-distribution-of-ki67-in-epidermis-of-thick-glabrous-skin-of-human-digits
#11
Aleksandar Petrovic, Vladimir Petrovic, Bobana Milojkovic, Ivan Nikolic, Dragan Jovanovic, Aleksandra Antovic, Miroslav Milic
The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67...
November 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29110080/pemphigus-trigger-factors-special-focus-on-pemphigus-vulgaris-and-pemphigus-foliaceus
#12
REVIEW
Soheil Tavakolpour
Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. In this study, several triggers, including different drugs and treatments, diseases, vaccines, genetic factors, nutrients, micronutrients, pregnancy, stress, and various other triggers have been discussed...
November 6, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29071428/ige-autoantibodies-and-their-association-with-the-disease-activity-and-phenotype-in-bullous-pemphigoid-a-systematic-review
#13
REVIEW
Ariadne Hadjikyriacou Saniklidou, Patrick J Tighe, Lucy C Fairclough, Ian Todd
Bullous pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII collagen (COL17) protein acting as the adhesion molecule between the epidermis and the basement membrane of the dermis. About 40 years ago, following consistent findings of elevated total serum IgE levels in BP patients, it was hypothesized that IgE may be involved in the pathophysiology of BP...
October 25, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29185104/5%C3%AE-reductase-isozymes-and-aromatase-mrna-levels-in-plucked-hair-from-young-women-with-female-pattern-hair-loss
#14
P Sánchez, C Serrano-Falcón, J M Torres, S Serrano, E Ortega
Female pattern hair loss (FPHL) is an important hair disorder, especially when young women are affected. However, pharmacological treatments are not successful in all women. Androgens, especially dihydrotestosterone (DHT), may play a role in FPHL, but many women with this disorder have normal serum androgen levels. It therefore appears that hair follicle levels of DHT depend on in situ testosterone (T) metabolism. Because T can be converted to DHT or estradiol (E2) by 5α-reductase (5α-R) and aromatase, respectively, these enzymes would determine DHT and E2 concentrations and their ratio...
January 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29018877/correction-to-digestive-system-in-psoriasis-an-update
#15
Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich
In the original publication, the data labels are incorrect in Fig. 3. The corrected Fig. 3 is given here.
November 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28905102/digestive-system-in-psoriasis-an-update
#16
REVIEW
Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich
Psoriasis is a chronic inflammatory immune-mediated disorder associated and often coexisting with many other immune-related clinical conditions including those affecting the gastrointestinal tract. Data obtained from the reviewed literature suggest an association between psoriasis and pathologies of the oral cavity, both psoriasis-specific lesions, as well as non-specific, such as geographic tongue or fissured tongue. These findings show the importance of thorough examination of oral mucosa in psoriatic patients...
November 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28884378/efficacy-of-topical-tofacitinib-in-promoting-hair-growth-in-non-scarring-alopecia-possible-mechanism-via-vegf-induction
#17
Jitlada Meephansan, J Thummakriengkrai, S Ponnikorn, W Yingmema, R Deenonpoe, P Suchonwanit
Tofacitinib is a Janus kinase 3 (JAK3) inhibitor that promotes hair growth; however, the efficacy and mechanism of this effect are not yet understood. This study aimed to evaluate the efficacy and mechanism of topical tofacitinib on hair growth in mice. Eight-week-old male C57BL/6 mice were divided equally into four groups and treated topically with tofacitinib, minoxidil, or vehicle once daily for 21 days. Weekly photographs were taken to determine the area and rate of hair growth, and tissue samples were collected for histopathological evaluation...
November 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28875235/incidence-of-bullous-pemphigoid-in-sweden-2005-2012-a-nationwide-population-based-cohort-study-of-3761-patients
#18
Kristofer Thorslund, Oliver Seifert, Karin Nilzén, Carina Grönhagen
Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005-2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified from the National Patient Register (NPR). The diagnosis of bullous pemphigoid in the NPR was recently validated from medical records, histopathological and immunopathological data by our group in a previous study...
November 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28852829/pal-12-a-new-anti-aging-hexa-peptoid-inhibits-uvb-induced-photoaging-in-human-dermal-fibroblasts-and-3d-reconstructed-human-full-skin-model-keraskin-ft%C3%A2
#19
Daeun Song, Hyeonji Park, Su-Hyon Lee, Mi Jung Kim, Eun-Joo Kim, Kyung-Min Lim
Peptoids are a class of peptidomimetics whose pharmacological activities are widely investigated owing to their remarkable biological stability. However, the utilities of peptoids as cosmetic functional ingredients have not been fully explored. Here, we investigated anti-aging effects of PAL-12, a new hexa-peptoid, on UVB-induced photoaging in human dermal fibroblasts (HDFs) and a 3D reconstituted human full skin model, Keraskin-FT™. PAL-12 suppressed matrix metalloproteinase-1 (MMP-1) expression induced by UVB irradiation along with the attenuation of MMP-1 secretion as determined by ELISA assay...
November 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29038846/a-possible-implication-of-reduced-levels-of-lif-lifr-and-gp130-in-vasculopathy-related-to-systemic-sclerosis
#20
Takashi Taniguchi, Takuya Miyagawa, Zenshiro Tamaki, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Takehiro Takahashi, Tetsuo Toyama, Yohei Ichimura, Ayumi Yoshizaki, Yayoi Tada, Makoto Sugaya, Takafumi Kadono, Shinichi Sato, Yoshihide Asano
Leukemia inhibitory factor (LIF) is a member of IL-6 family, which serves as a potent chemoattractant for neutrophils as well as a potent angiostatic factor. LIF has been implicated in various autoimmune inflammatory diseases, but its role still remains elusive in systemic sclerosis (SSc). Therefore, we investigated the potential role of LIF in the development of SSc by evaluating the clinical correlation of serum LIF levels, the expression of LIF and its receptors in skin samples, and in vitro experiments with human dermal microvascular endothelial cells...
October 16, 2017: Archives of Dermatological Research
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