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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/28324170/microscopic-and-ultrastructural-evidences-in-human-skin-following-calcium-hydroxylapatite-filler-treatment
#1
Nicola Zerbinati, Edoardo D'Este, Pier Camillo Parodi, Alberto Calligaro
This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated tissue support-specific mechanism involved in the structural modifications of both filler microspherules and cells of the connective tissue. They demonstrate the absence of any immunological reaction and show that the used filler is modified very slowly over time by the action of cells of the connective tissue closely related to the filler without any activity of phagocytosis...
March 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28321536/effect-of-sinapic-acid-on-hair-growth-promoting-in-human-hair-follicle-dermal-papilla-cells-via-akt-activation
#2
Hyunju Woo, Seungjun Lee, Seungbeom Kim, Deokhoon Park, Eunsun Jung
Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. The objective of this research was to identify new compound that can be used as a drug to promote hair growth...
March 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28317060/prognostic-factors-for-mortality-in-patients-with-bullous-pemphigoid-a-meta-analysis
#3
Yi-Di Liu, Yan-Hong Wang, Yi-Cong Ye, Wen-Ling Zhao, Li Li
Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed considerably various results. This meta-analysis aimed to quantitatively assess the association between several potential prognostic factors and risk of mortality in bullous pemphigoid. A comprehensive search was performed using Pubmed, Embase, and Cochrane Library...
March 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28314913/laser-and-light-based-therapy-for-cutaneous-and-soft-tissue-metastases-of-malignant-melanoma-a-systematic-review
#4
REVIEW
Evan Austin, Andrew Mamalis, Derek Ho, Jared Jagdeo
Invasive cutaneous melanoma is a growing health concern. Although surgical excision can effectively treat in situ tumors, use for metastatic melanoma is limited. Laser and light-based therapies may be a valuable palliative treatment option for patients with stage III and stage IV cutaneous metastatic melanoma. Our goal is to review the published literature and provide evidence-based recommendations on laser and light-based palliative therapies for metastatic melanoma. A search of the databases Pubmed, EMBASE, Web of Science, and CINAHL was performed on March 10, 2016...
March 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28314912/differences-in-the-melanosome-distribution-within-the-epidermal-melanin-units-and-its-association-with-the-impairing-background-of-leukoderma-in-vitiligo-and-halo-nevi-a-retrospective-study
#5
Xi-Xi Xiong, Gao-Zhong Ding, Wen-E Zhao, Xue Li, Yu-Ting Ling, Li Sun, Qing-Li Gong, Yan Lu
Skin color is determined by the number of melanin granules produced by melanocytes that are transferred to keratinocytes. Melanin synthesis and the distribution of melanosomes to keratinocytes within the epidermal melanin unit (EMU) within the skin of vitiligo patients have been poorly studied. The ultrastructure and distribution of melanosomes in melanocytes and surrounding keratinocytes in perilesional vitiligo and normal skin were investigated using transmission electron microscopy (TEM). Furthermore, we performed a quantitative analysis of melanosome distribution within the EMUs with scatter plot...
March 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28303329/diagnostic-performance-of-transient-elastography-for-detection-of-methotrexate-induced-liver-injury-using-roenigk-classification-in-asian-patients-with-psoriasis-a-retrospective-study
#6
Pasinee Rongngern, Leena Chularojanamontri, Chanisada Wongpraparut, Narumol Silpa-Archa, Watcharasak Chotiyaputta, Ananya Pongpaibul, Phunchai Charatcharoenwitthaya
Liver biopsy, the gold standard for monitoring methotrexate-induced liver fibrosis in psoriasis patients, has potential morbidity and mortality. Transient elastography (TE) has been widely used as an alternative non-invasive method. Currently, psoriasis-specific data of TE comparing to Roenigk histopathology is lacking. This retrospective study assessed the diagnostic performance of TE in the detection of methotrexate-induced liver injury and liver fibrosis in Asian psoriasis patients. Risk factors that associated with liver injury by TE and histopathology were also determined...
March 16, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28303328/effects-of-palmitoyl-kvk-l-ascorbic-acid-on-skin-wrinkles-and-pigmentation
#7
Hyeong Mi Kim, Hyo Sun An, Jung-Soo Bae, Jung Yun Kim, Chi Ho Choi, Ju Yeon Kim, Joo Hyuck Lim, Joon-Hun Choi, Hyunnam Song, Sung Ho Moon, Young Jun Park, Shin-Jae Chang, Sun Young Choi
Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl-KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial...
March 16, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28299442/interleukin-il-18-cooperatively-with-il-23-induces-prominent-inflammation-and-enhances-psoriasis-like-epidermal-hyperplasia
#8
Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Takayuki Yoshimoto, Chikako Nishigori
The interleukin (IL)-23/IL-17 axis is strongly implicated in the pathogenesis of psoriasis. Previous studies showed that IL-18 was elevated in early active and progressive plaque-type psoriatic lesions and that serum or plasma levels of IL-18 correlated with the Psoriasis Area and Severity Index. However, the mechanism whereby IL-18 affects disease severity remains unknown. In this study, we investigated the effects of IL-18 on a psoriasis-like skin inflammation model induced by recombinant mouse IL-23. We found that IL-18, cooperatively with IL-23, induced prominent inflammation and enhanced psoriasis-like epidermal hyperplasia...
March 15, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28285367/comparison-of-protective-effect-of-ascorbic-acid-on-redox-and-endocannabinoid-systems-interactions-in-in-vitro-cultured-human-skin-fibroblasts-exposed-to-uv-radiation-and-hydrogen-peroxide
#9
Agnieszka Gęgotek, Katarzyna Bielawska, Michał Biernacki, Ilona Zaręba, Arkadiusz Surażyński, Elżbieta Skrzydlewska
The mechanisms of biological activity of commonly used natural compounds are constantly examined. Therefore, the aim of this study was to compare ascorbic acid efficacy in counteracting the consequences of UV and hydrogen peroxide treatment on lipid mediators and their regulative action on antioxidant abilities. Skin fibroblasts exposed to UVA and UVB irradiation, treated with hydrogen peroxide and ascorbic acid. The redox system was estimated through reactive oxygen species (ROS) generation (electron spin resonance spectrometer) and antioxidants level/activity (HPLC/spectrometry) which activity was evaluated by the level of phospholipid metabolites: 4-hydroxynonenal, malondialdehyde, 8-isoprostanes and endocannabinoids (GC/LC-MS) in the human skin fibroblasts...
March 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28285366/nonmelanoma-skin-cancer-and-risk-of-all-cause-and-cancer-related-mortality-a-systematic-review
#10
Virginia Barton, Kent Armeson, Shalaka Hampras, Laura K Ferris, Kala Visvanathan, Dana Rollison, Anthony J Alberg
Some reports suggest that a history of nonmelanoma skin cancer (NMSC) may be associated with increased mortality. NMSCs have very low fatality rates, but the high prevalence of NMSC elevates the importance of the possibility of associated subsequent mortality from other causes. The variable methods and findings of existing studies leave the significance of these results uncertain. To provide clarity, we conducted a systematic review to characterize the evidence on the associations of NMSC with: (1) all-cause mortality, (2) cancer-specific mortality, and (3) cancer survival...
March 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28283753/cosmetic-applications-of-glucitol-core-containing-gallotannins-from-a-proprietary-phenolic-enriched-red-maple-acer-rubrum-leaves-extract-inhibition-of-melanogenesis-via-down-regulation-of-tyrosinase-and-melanogenic-gene-expression-in-b16f10-melanoma-cells
#11
Hang Ma, Jialin Xu, Nicholas A DaSilva, Ling Wang, Zhengxi Wei, Liangran Guo, Shelby L Johnson, Wei Lu, Jun Xu, Qiong Gu, Navindra P Seeram
The red maple (Acer rubrum) is a rich source of phenolic compounds which possess galloyl groups attached to different positions of a 1,5-anhydro-D-glucitol core. While these glucitol-core containing gallotannins (GCGs) have reported anti-oxidant and anti-glycative effects, they have not yet been evaluated for their cosmetic applications. Herein, the anti-tyrosinase and anti-melanogenic effects of a proprietary phenolic-enriched red maple leaves extract [Maplifa(™); contains ca. 45% ginnalin A (GA) along with other GCGs] were investigated using enzyme and cellular assays...
March 10, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28280914/differentiation-of-pityriasis-rubra-pilaris-from-plaque-psoriasis-by-dermoscopy
#12
N E Abdel-Azim, S A Ismail, E Fathy
Pityriasis rubra pilaris (PRP) and plaque psoriasis (PP) are two distinctive erythemato-squamous skin diseases that often have to be differentiated from each other and from other similar dermatoses. Dermoscopy has been proven to aid the clinical diagnosis of several inflammatory disorders, minimizing the need for skin biopsy. Our aim was to determine the dermoscopic patterns of PRP compared to PP and to assess the significance of certain dermoscopic criteria in the diagnosis of PRP. This case-control study included 11 patients with biopsy proven PRP and 25 patients with biopsy proven plaque psoriasis...
March 9, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28271213/the-influence-of-probiotics-for-preterm-neonates-on-the-incidence-of-atopic-dermatitis-results-from-a-historically-controlled-cohort-study
#13
Julie A Damm, Birgitte Smith, Gorm Greisen, Karen A Krogfelt, Maja-Lisa Clausen, Tove Agner
Probiotic supplementation is a promising preventive strategy for atopic dermatitis (AD). To help clarifying the significance of timing with respect to prevention of AD, we here evaluate the benefit of prophylactic use of probiotic supplementation in neonates younger than 30 weeks of gestation. Preterm children from the Department of Neonatology, Rigshospitalet, Denmark from two different admission periods were included in a historically controlled cohort study. Neonates from January 2007 to February 2010, not treated with and neonates from March 2010 to February 2013 treated with probiotic were enrolled...
March 7, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28255674/testing-of-viable-human-skin-cell-dilution-cultures-as-an-approach-to-validating-microsampling
#14
Stephen A Ainger, X L Hilary Yong, H Peter Soyer, Richard A Sturm
Skin biopsies are a valuable technique in the diagnosis of cutaneous inflammatory and neoplastic conditions. We were interested to test the minimal size or equivalent volume by dilution of proteolytically disassociated skin tissue required to allow the isolation and propagation of cutaneous cells, for freezing, storage and biochemical analysis. It was possible to propagate with 100% efficiency fibroblast and melanocytic cells from a 0.1 to 0.5 mm(3) equivalent neonatal foreskin sample using a combination of DispaseII and CollagenaseIV...
March 3, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28251309/relationship-between-biochemical-factors-and-skin-symptoms-in-chronic-venous-disease
#15
Yasushi Takai, Keiichi Hiramoto, Yoshiyuki Nishimura, Kazuya Ooi
Chronic venous disease (CVD) is a common venous disease of the lower extremities and patients often develop symptoms of itching and skin roughness. An easy to use and objective skin examination was recently developed that allows measurement of the level of stratum corneum content and transepidermal water loss (TEWL), which can indicate the status of the barrier function of the stratum corneum. Previous studies demonstrated that histamine production from mast cells, and tryptase and matrix metalloprotease-9 levels were associated with skin inflammation...
March 1, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28247017/topical-stabilized-retinol-treatment-induces-the-expression-of-has-genes-and-ha-production-in-human-skin-in-vitro-and-in-vivo
#16
Wen-Hwa Li, Heng-Kuan Wong, José Serrano, Manpreet Randhawa, Simarna Kaur, Michael D Southall, Ramine Parsa
Skin Aging manifests primarily with wrinkles, dyspigmentations, texture changes, and loss of elasticity. During the skin aging process, there is a loss of moisture and elasticity in skin resulting in loss of firmness finally leading to skin sagging. The key molecule involved in skin moisture is hyaluronic acid (HA), which has a significant water-binding capacity. HA levels in skin decline with age resulting in decrease in skin moisture, which may contribute to loss of firmness. Clinical trials have shown that topically applied ROL effectively reduces wrinkles and helps retain youthful appearance...
February 28, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28238185/can-signal-peptide-cub-egf-domain-containing-protein-scube-levels-be-a-marker-of-angiogenesis-in-patients-with-psoriasis
#17
Arzu Aydın Capkin, Selim Demir, Ahmet Mentese, Çağlar Bulut, Ahmet Ayar
Angiogenesis is an important process being involved in the pathogenesis of psoriasis and promises new potential parameter for diagnosis and screening of treatment. This study investigated the levels of signal peptide-CUB-EGF (epidermal growth factor-like protein) family domain-containing protein (SCUBE) 1 and 3. Potential value as a novel marker of angiogenesis in patients with psoriasis is also evaluated by assessing possible relation of SCUBE-1 and 3 with disease activity in conjunction with vascular endothelial growth factor (VEGF) levels, as an established marker of angiogenesis...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28229231/hair-follicle-changes-following-intense-pulsed-light-axillary-hair-reduction-histometrical-histological-and-immunohistochemical-evaluation
#18
Moetaz El-Domyati, Wael Hosam, Noha H Moftah, Hamza Abdel Raouf, Selwet M Saad
Intense pulsed light (IPL) has been used for years in hair reduction; however, no previous studies discussed quantitative histological and immunohistochemical changes of hair follicles after IPL. Accordingly, this study aims to objectively quantify histological and immunohistochemical changes of hair follicles after IPL hair reduction. Right axillae of 21 volunteers were subjected to 6 IPL sessions using Quanta system IPL and evaluated at 1 week and 1 month after last session (i.e., 3 and 4 months from the start of treatment, respectively) in comparison to baseline and left control axillae...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28229230/mycobacterium-ulcerans-mycolactone-interferes-with-adhesion-migration-and-proliferation-of-primary-human-keratinocytes-and-hacat-cell-line
#19
Francesca Graziola, Elena Colombo, Rossana Tiberio, Giorgio Leigheb, Chiarella Bozzo
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential activities on two primary human keratinocyte populations, keratinocyte stem cells (KSC) and transit amplifying cells (TAC), and on a human keratinocyte line, HaCaT. We demonstrated that 0.01 and 0...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28213804/psoriasis-and-cardiovascular-events-updating-the-evidence
#20
Line Raaby, Ole Ahlehoff, Annette de Thurah
So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0-1...
April 2017: Archives of Dermatological Research
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