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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/27885419/ketoconazole-inhibits-malassezia-furfur-morphogenesis-in-vitro-under-filamentation-optimized-conditions
#1
Sirida Youngchim, Joshua D Nosanchuk, Siriporn Chongkae, Nongnuch Vanittanokom
Malassezia furfur, a constituent of the normal human skin flora, is an etiological agent of pityriasis versicolor, which represents one of the most common human skin diseases. Under certain conditions, both exogenous and endogenous, the fungus can transition from a yeast form to a pathogenic mycelial form. To develop a standardized medium for reproducible production of the mycelial form of M. furfur to develop and optimize susceptibility testing for this pathogen, we examined and characterized variables, including kojic acid and glycine concentration, agar percentage, and pH, to generate a chemically defined minimal medium on which specific inoculums of M...
November 24, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27878387/genetic-susceptibility-to-cutaneous-radiation-injury
#2
REVIEW
Amy Huang, Sharon A Glick
The use of ionizing radiation is critical to cancer treatment and fluoroscopic procedures. However, despite efforts to minimize total radiation dose, many patients experience toxic cutaneous side-effects of ionizing radiation, ranging from mild erythema to subcutaneous fibrosis, telangiectasia formation, and ulceration. Extent of injury is highly variable among patients. Studying the genetic determinants of radiation injury can help develop protocols to reduce radiation toxicity, as well as drive research into effective modulators of the genes and gene products associated with radiation injury...
November 22, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27864629/cytokeratin-ae1-ae3-immunostaining-and-3d-histology-improvement-of-diagnosis-in-desmoplastic-squamous-cell-carcinoma-of-the-skin
#3
Katrin Schweinzer, Lukas Kofler, Jürgen Bauer, Gisela Metzler, Helmut Breuninger, Hans-Martin Häfner
Desmoplastic squamous cell carcinoma (DSCC) as a rare subtype of cutaneous SCC has specific histological features, characterized by columns, bands, and strands of squamoid cells infiltrating a dense collagenous stroma. To decrease the high rates of local recurrence in DSSC, improvement of diagnostic methods is highly demanded. Objective was to evaluate whether immunohistochemistry (IHC) is suited to increase diagnostic accuracy. A total number of 18 patients were included in this study. After recutting of the original paraffin blocks, parallel staining of serial sections with conventionally H&E and cytokeratin AE1/AE3-immunohistochemical staining was performed...
November 18, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27833999/methyl-%C3%AE-cyclodextrin-treatment-combined-to-incubation-with-interleukin-4-reproduces-major-features-of-atopic-dermatitis-in-a-3d-culture-model
#4
Tatiana do Nascimento Pedrosa, Evelyne De Vuyst, Abdallah Mound, Catherine Lambert de Rouvroit, Silvya Stuchi Maria-Engler, Yves Poumay
Atopic dermatitis (AD) skin is characterized by over-expression of interleukin (IL)-4, IL-13 and IL-25. When methyl-β-cyclodextrin (MβCD) treatment preceded exposure to these interleukins, combination of both treatments was found to mimic hallmarks of AD in vitro, such as barrier weakening, histological alterations and typical signaling responses in a reconstructed human epidermis (RHE). However, the respective role of each IL and whether any of them is critical when combined with MβCD treatment was unknown...
November 11, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27783153/epidermal-hydrogen-peroxide-is-not-increased-in-lesional-and-non-lesional-skin-of-vitiligo
#5
Mohammad Z Zailaie
It is widely believed that the loss of the epidermal melanocytes in vitiligo is basically due to excessive oxidative stress. Previous research work described abnormal elevation of the absolute concentration of the epidermal hydrogen peroxide (H2O2) in lesional and non-lesional skin of vitiligo. Based on this finding, our primary research objective was to use this feature as a screening marker in individuals at a great risk of developing vitiligo. Ninety-six patients of non-segmental vitiligo (NSV) of varying durations, skin phototypes, and treatment modalities (psoralen UVA-, narrow band UVB-treated) were recruited for this study...
October 25, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27770201/histopathological-and-immunological-changes-during-the-acute-and-recovery-phase-in-henoch-sch%C3%A3-nlein-purpura-rabbit-model
#6
Yanhong Li, Xiaolong Sui, Hua Zhu, Yanfeng Xu, Lan Huang, Yuhuan Xu, Yunlin Han, Xiaochun Feng, Chuan Qin
Henoch-Schönlein purpura (HSP) is a systemic vasculitis mediated by autologous immune complex. Animal models of HSP are scarce. Here, we describe the characteristics of HSP rabbit model in the acute and recovery phase. First, we constructed the HSP rabbit models, and then assessed immunologic indicators of models by enzyme-linked immunosorbent assay and immunoturbidimetry. Histomorphological characteristics were analyzed by haematoxylin-eosin, immunofluorescence and special staining. In the acute stage (24 h) after antigen challenge, the model group rabbits featured skin ecchymosis and abnormal laboratory examination results...
October 21, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27766406/cd164-identifies-cd4-t-cells-highly-expressing-genes-associated-with-malignancy-in-s%C3%A3-zary-syndrome-the-s%C3%A3-zary-signature-genes-fcrl3-tox-and-mir-214
#7
Bernice M Benoit, Neha Jariwala, Geraldine O'Connor, Landon K Oetjen, Timothy M Whelan, Adrienne Werth, Andrea B Troxel, Hélène Sicard, Lisa Zhu, Christopher Miller, Junko Takeshita, Daniel W McVicar, Brian S Kim, Alain H Rook, Maria Wysocka
Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), is associated with a significantly shorter life expectancy compared to skin-restricted mycosis fungoides. Early diagnosis of SS is, therefore, key to achieving enhanced therapeutic responses. However, the lack of a biomarker(s) highly specific for malignant CD4(+) T cells in SS patients has been a serious obstacle in making an early diagnosis. We recently demonstrated the high expression of CD164 on CD4(+) T cells from Sézary syndrome patients with a wide range of circulating tumor burdens...
October 20, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27744496/the-ikk%C3%AE-dependent-non-canonical-pathway-of-nf-%C3%AE%C2%BAb-activation-is-constitutively-active-and-modulates-progression-related-functions-in-a-subset-of-human-melanomas
#8
Nadin Dewert, Katharina Amschler, Verena Lorenz, Michael P Schön
Owing to activation of several resistance-mediating pathways including NF-κB signaling, metastasized melanoma is almost universally resistant against chemotherapy. Given that blocking of NF-κB either by proteasome-, pan-IKK- or selective IKKβ-inhibitors may increase the susceptibility of melanoma cells to chemotherapy, we have assessed the role of the second kinase within the IKK complex, IKKα. While expression of IKKα and overall activation of NF-κB were heterogeneous, the IKKα-specific p100/p52 processing was detected in a small subset of melanomas (1/9 primary and 1/12 metastatic melanomas) as well as in 1/8 melanoma cell lines...
October 15, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27722782/low-concentration-hydrogen-peroxide-can-upregulate-keratinocyte-intracellular-calcium-and-par-2-expression-in-a-human-keratinocyte-melanocyte-co-culture-system
#9
Jian Li, Lu-Yan Tang, Wen-Wen Fu, Jin Yuan, You-Yu Sheng, Qin-Ping Yang
Hydrogen peroxide (H2O2) may have a biphasic effect on melanin synthesis and melanosome transfer. High H2O2 concentrations are involved in impaired melanosome transfer in vitiligo. However, low H2O2 concentration promotes the beneficial proliferation and migration of melanocytes. The aim of this study was to explore low H2O2 and its mechanism in melanosome transfer, protease-activated receptor-2 (PAR-2) expression and calcium balance. Melanosomes were fluorescein-labeled for clear visualization of their transfer...
October 8, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27709295/topically-applied-manganese-porphyrins-bmx-001-and-bmx-010-display-a-significant-anti-inflammatory-response-in-a-mouse-model-of-allergic-dermatitis
#10
Kelsey Stover, Tomoki Fukuyama, Ashlyn T Young, Michael A Daniele, Rebecca Oberley, James D Crapo, Wolfgang Bäumer
In this study, we topically administered two antioxidant compounds, the manganese-porphyrin-derivatives BMX-001 and BMX-010, in a mouse model of allergic dermatitis and compared the efficacy for reduction of itch and inflammation. In vitro effects of BMX-001 and BMX-010 on keratinocytes, bone marrow derived dendritic cells (BMDCs) and T-cells were initially analysed. For assessment of scratching behaviour, BMX-001 and BMX-010 (0.01 and 0.1 %) were topically applied 16 h and/or 1 h before compound 48/80 or toluene-2,4,-diisocyanate (TDI) challenge in a TDI induced mouse dermatitis model...
October 5, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27704205/complete-prevention-of-radiation-induced-dermatitis-using-topical-adrenergic-vasoconstrictors
#11
William E Fahl
Radiation dermatitis is a commonly occurring, painful, side effect of cancer radiotherapy that causes some patients to withdraw from the radiotherapy course. Our goal was to test and optimize topical application of an adrenergic vasoconstrictor to rat skin in a preclinical test to prevent radiation-induced dermatitis. A radiation dermatitis assay was developed in which 17.2 Gy to a 1.5 × 3.0 cm rectangle on the clipped dorsal back of rats yielded Grade 3 radiation dermatitis over the irradiated area 13 days later...
October 4, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27687555/enhanced-th1-and-th17-responses-in-peripheral-blood-in-active-non-segmental-vitiligo
#12
Yu Zhen, Lei Yao, Shuxia Zhong, Yang Song, Yan Cui, Shanshan Li
Accumulating studies have indicated that vitiligo, especially non-segmental vitiligo (NSV), is one kind of autoimmune diseases and CD4(+) T cells play important roles in the pathogenesis. However, there have been very limited data on the detailed changes of each of the CD4(+) T cell subsets in periphery in active NSV. To clarify this issue, we collected the peripheral blood mononuclear cells (PBMCs) from 30 patients with active NSV and 30 age- and sex-matched healthy controls. The percentages of circulating Th1, Th2, Th17 and Tregs were evaluated using flow cytometry and the expressions of their specific transcription factors T-bet, GATA3, RORγt and FOXP3 at mRNA level and protein levels were qualified by qPCR and flow cytometry, respectively...
September 29, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27683230/effects-of-gadodiamide-on-cell-proliferation-and-collagen-production-in-cultured-human-dermal-fibroblasts
#13
Yumi Ozawa, Shujiro Hayashi, Yoichiro Hamasaki, Atsushi Hatamochi
Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents can trigger NSF. To date, however, the exact mechanism underlying the induction of fibrosis in various organs by Gd remains unexplained. This study was undertaken to evaluate the influence of Gd on the proliferation activity and collagen production of cultured fibroblasts...
September 28, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27744497/hyperhidrosis-an-update-on-prevalence-and-severity-in-the-united-states
#14
James Doolittle, Patricia Walker, Thomas Mills, Jane Thurston
Current published estimates of the prevalence of hyperhidrosis in the United States are outdated and underestimate the true prevalence of the condition. The objectives of this study are to provide an updated estimate of the prevalence of hyperhidrosis in the US population and to further assess the severity and impact of sweating on those affected by the condition. For the purposes of obtaining prevalence, a nationally representative sample of 8160 individuals were selected using an online panel, and information as to whether or not they experience hyperhidrosis was obtained...
December 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27655635/effects-of-insulin-on-the-skin-possible-healing-benefits-for-diabetic-foot-ulcers
#15
REVIEW
T Emanuelli, A Burgeiro, E Carvalho
Diabetic foot ulcers affect 15-20 % of all diabetic patients and remain an important challenge since the available therapies have limited efficacy and some of the novel therapeutic approaches, which include growth factors and stem cells, are highly expensive and their safety remains to be evaluated. Despite its low cost and safety, the interest for topical insulin as a healing agent has increased only in the last 20 years. The molecular mechanisms of insulin signaling and its metabolic effects have been well studied in its classical target tissues...
December 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27664090/estimated-serum-vitamin-d-status-vitamin-d-intake-and-risk-of-incident-alopecia-areata-among-us-women
#16
Jordan M Thompson, Tricia Li, Min Kyung Park, Abrar A Qureshi, Eunyoung Cho
Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the association between estimated vitamin D status, derived from a prediction model incorporating lifestyle determinants of serum vitamin D, and self-reported incident AA. We evaluated dietary, supplemental, and total vitamin D intake as additional exposures...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27650274/il-4-and-human-skin-mast-cells-revisited-reinforcement-of-a-pro-allergic-phenotype-upon-prolonged-exposure
#17
Magda Babina, Sven Guhl, Metin Artuc, Torsten Zuberbier
Mast cells (MCs), unique cellular elements of the body, are commonly associated with IgE-mediated reactions and manifestations of Th2-type immunity. A key characteristic of the lineage is its heterogeneity, with subsets displaying significant variation depending on maturation stage, species, tissue, microenvironment and other. Heterogeneity also affects MC responses to extracellular cues. Indeed, IL-4, the signature cytokine of Th2-immunity, can affect MCs in opposing ways ranging from the induction of apoptosis to positive regulation of lineage characteristics...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27623800/anti-wrinkle-and-anti-whitening-effects-of-juc%C3%A3-libidibia-ferrea-mart-extracts
#18
Tatiana do Nascimento Pedrosa, Aline Oliveira Barros, Jéssica Rodrigues Nogueira, Andréa Costa Fruet, Isis Costa Rodrigues, Danielle Queiroz Calcagno, Marilia de Arruda Cardoso Smith, Tatiane Pereira de Souza, Silvia Berlanga de Moraes Barros, Marne Carvalho de Vasconcellos, Felipe Moura Araújo da Silva, Hector Henrique Ferreira Koolen, Silvya Stuchi Maria-Engler, Emerson Silva Lima
Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-wrinkle and anti-whitening potentials of jucá trunk bark (LFB) and pod (LFP) extracts. A comprehensive analysis of LFB and LFP phenolic composition was accomplished by means of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27613059/an-association-between-newly-diagnosed-cutaneous-t-cell-lymphoma-and-prior-impetigo-a-nested-case-control-study
#19
Ben Boursi, Kevin Haynes, Ronac Mamtani, Yu-Xiao Yang
Colonization with staphylococcus aureus (SA) is associated with disease activity and progression in patients with cutaneous T-cell lymphoma (CTCL) secondary to T-cell activation by bacterial superantigens. The aim of the current study was to evaluate the possible role of SA as an etiologic factor affecting CTCL initiation. We conducted a nested case-control study in a large population-representative database from the UK. Cases were defined as all patients with an incident diagnosis of mycosis fungoides (MF) or Sezary syndrome (SS) between 1995 and 2013...
November 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27600510/itraq-based-quantitative-proteomics-of-stratum-corneum-of-dandruff-scalp-reveals-new-insights-into-its-aetiology-and-similarities-with-atopic-dermatitis
#20
Nükhet Cavusoglu, Caroline Delattre, Mark Donovan, Sylvie Bourassa, Arnaud Droit, Charles El Rawadi, Roland Jourdain, Dominique Bernard
The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological functions provided new insights into the affected metabolic pathways of a dandruff scalp. Dandruff scalp showed (1) profound changes in the expression and maturation of structural and epidermal differentiation related proteins, that are responsible for the integrity of the skin, (2) altered relevant factors that regulate skin hydration, and (3) an imbalanced physiological protease-protease inhibitor ratio...
November 2016: Archives of Dermatological Research
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