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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/29774387/ultraviolet-radiation-induces-melan-a-expressing-cells-in-interfollicular-epidermis-in-wild-type-mice
#1
David A De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch
Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice...
May 17, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29761213/can-such-an-animal-model-truly-represent-henoch-sch%C3%A3-nlein-purpura
#2
LETTER
Fengying Wang, Ruyue Chen, Xiaozhong Li, Yunyan Shen
No abstract text is available yet for this article.
May 14, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29752541/stratum-corneum-substantivity-drug-development-implications
#3
REVIEW
Becky S Li, John Havens Cary, Howard I Maibach
There are at least 15 factors that influence the ability of chemicals to penetrate the skin. Substantivity is yet another factor and allows penetrants to remain on and in skin for many days. As many skin pathologies involve stratum corneum and require multiple dosing of topicals, understanding substantivity mechanisms may provide insight for topical dosing strategies. Substantivity is also of importance in the development of other consumer products that necessitate adherence to skin, including sunscreens, insect repellents, and cosmetics...
May 11, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29737404/characterization-and-survival-of-patients-with-metastatic-basal-cell-carcinoma-in-the-department-of-veterans-affairs-a-retrospective-electronic-health-record-review
#4
Vanessa W Stevens, David D Stenehjem, Olga V Patterson, Aaron W C Kamauu, Yeun Mi Yim, Robert J Morlock, Scott L DuVall
Available descriptive statistics for patients with metastatic basal cell carcinoma (mBCC) are limited. To describe disease characteristics, treatment patterns, survival outcomes, and prognostic factors of patients with mBCC, we conducted a retrospective review of electronic health records in the Department of Veterans Affairs (VA). The primary outcome was survival. Data were also collected on demographics, comorbidities, medications, and procedures. Median (IQR) age of patients with mBCC (n = 475) was 72...
May 8, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728859/up-regulation-of-hmgb1-and-tlr4-in-skin-lesions-of-lichen-planus
#5
Gabriel Costa de Carvalho, Fabiana Yasumoto Araujo Hirata, Rosana Domingues, Cristina Adelaide Figueiredo, Mariana Colombini Zaniboni, Naiura Vieira Pereira, Mirian Nacagami Sotto, Valéria Aoki, Alberto José da Silva Duarte, Maria Notomi Sato
Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns) may also contribute to the inflammatory response in LP. HMGB1 (high mobility group box 1 protein) is one of the major DAMPs that induces inflammation and could trigger LP disease. The present study was aimed to examine TLR4, RAGE and HMGB1 production in epidermis or dermis by immunohistochemistry and the respective expression of these targets in the skin lesions of patients with LP...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728858/amelioration-of-lactic-acid-sensations-in-sensitive-skin-by-stimulating-the-barrier-function-and-improving-the-ceramide-profile
#6
Hiroshi Nojiri, Koichi Ishida, Xueqiu Yao, Wei Liu, Genji Imokawa
We determined whether compensating ceramides in the stratum corneum (SC) may ameliorate the impaired barrier function and subsequently attenuate the enhanced skin sensitivity. Treatment for 4 weeks with the ceramide complex cream or the placebo cream significantly ameliorated the intensity of lactic acid sensations in 39 female subjects with sensitive skin, the degree of which was attenuated to a greater extent at 1 week by the ceramide complex cream compared with the placebo cream. The amelioration of skin sensations was accompanied by a significant increase in total ceramide content in the SC elicited by the ceramide complex cream that was significantly more effective than the placebo cream at 4 weeks...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728857/cxcl13-is-an-activity-marker-for-systemic-but-not-cutaneous-lupus-erythematosus-a-longitudinal-cohort-study
#7
Anna Niederkorn, Julia Frühauf, Gerold Schwantzer, Nora Wutte, Clemens Painsi, Stefan Werner, Martin Stradner, Andrea Berghold, Josef Hermann, Elisabeth Aberer
Serum levels of the IFN-regulated cytokine CXCL13 have been found to correlate with SLEDAI and renal involvement in systemic lupus erythematosus. This study investigates whether CXCL13 can also be a marker of disease activity in patients with subacute cutaneous or chronic cutaneous lupus erythematosus (SCLE, CCLE). We analysed CXCL13 levels in 60 patients' sera (18 SLE, 19 SCLE, 23 CCLE) at five time points within 1 year and correlated these levels with disease activity scores and laboratory markers. Clinical scores with no/mild, moderate or high/severe disease activity were categorized by SLEDAI in SLE, by CLASI in SCLE/CCLE...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29725758/ex-vivo-nonlinear-microscopy-imaging-of-ehlers-danlos-syndrome-affected-skin
#8
Norbert Kiss, Dóra Haluszka, Kende Lőrincz, Enikő Kuroli, Judit Hársing, Balázs Mayer, Sarolta Kárpáti, György Fekete, Róbert Szipőcs, Norbert Wikonkál, Márta Medvecz
Ehlers-Danlos syndrome (EDS) is the name for a heterogenous group of rare genetic connective tissue disorders with an overall incidence of 1 in 5000. The histological characteristics of EDS have been previously described in detail in the late 1970s and early 1980s. Since that time, the classification of EDS has undergone significant changes, yet the description of the histological features of collagen morphology in different EDS subtypes has endured the test of time. Nonlinear microscopy techniques can be utilized for non-invasive in vivo label-free imaging of the skin...
May 3, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29704126/dermal-white-adipose-tissue-undergoes-major-morphological-changes-during-the-spontaneous-and-induced-murine-hair-follicle-cycling-a-reappraisal
#9
April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Paus
In murine skin, dermal white adipose tissue (DWAT) undergoes major changes in thickness in synchrony with the hair cycle (HC); however, the underlying mechanisms remain unclear. We sought to elucidate whether increased DWAT thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain the decreased DWAT thickness during catagen. In addition, we compared HC-associated DWAT changes between spontaneous and depilation-induced hair follicle (HF) cycling to distinguish between spontaneous and HF trauma-induced events...
April 27, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29687328/determinants-of-quality-of-life-and-psychological-status-in-adults-with-psoriasis
#10
Zhenli Kwan, Yii Bonn Bong, Leng Leng Tan, Shu Xian Lim, Adrian Sze Wai Yong, Chin Chwen Ch'ng, Maw Pin Tan, Rokiah Ismail
We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively...
April 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29633015/expression-of-il33-and-il35-in-oral-lichen-planus
#11
L R Javvadi, V P B Parachuru, T J Milne, G J Seymour, Alison M Rich
Oral lichen planus (OLP) is a complex immunological disorder, mediated in part by the release of cytokines by activated T-cells. Recently, the role of novel cytokines including IL33 and IL35 has been described in various chronic inflammatory diseases. IL33, a member of the IL-1 superfamily of cytokines, functions as an 'alarmin' released after cell necrosis to alert the immune system to tissue damage or stress. IL35, a member of IL12 cytokine family, is produced by regulatory T-cells and suppresses the immune response...
April 9, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29605863/increased-tenascin-c-and-dkk1-in-vitiligo-possible-role-of-fibroblasts-in-acral-and-non-acral-disease
#12
Samia M Esmat, Heba H El Hadidi, Rehab A Hegazy, Heba I Gawdat, Amira M Tawdy, Marwa M Fawzy, Dalia M AbdelHalim, Omnia S Sultan, Olfat G Shaker
Recently, multiple culprits-in addition to melanocytes-have been implicated in the pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has not been clearly elucidated. The aim of the study was to evaluate the possible role played by fibroblasts in vitiligo via studying the expression Tenascin C and DKK1 in acral versus non-acral vitiligo lesions. This case-control study included 19 non-segmental vitiligo patients and ten controls. All patients were subjected to thorough clinical evaluation...
March 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29574575/dimethyl-fumarate-dmf-vs-monoethyl-fumarate-mef-salts-for-the-treatment-of-plaque-psoriasis-a-review-of-clinical-data
#13
REVIEW
Lilla Landeck, Khusru Asadullah, Adriana Amasuno, Ignasi Pau-Charles, Ulrich Mrowietz
Fumarates (fumaric acid esters, FAEs) are orally administered systemic agents used for the treatment of psoriasis and multiple sclerosis. In 1994, a proprietary combination of FAEs was licensed for psoriasis by the German Drug Administration for use within Germany. Since then, fumarates have been established as one of the most commonly used treatments for moderate-to-severe psoriasis in Germany and other countries. The licensed FAE formulation contains dimethyl fumarate (DMF), as well as calcium, zinc, and magnesium salts of monoethyl fumarate (MEF)...
March 24, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29564550/uva-photoprotective-potential-of-silymarin-and-silybin
#14
Alena Rajnochová Svobodová, Eva Gabrielová, Loizos Michaelides, Pavel Kosina, Alena Ryšavá, Jitka Ulrichová, Bohumil Zálešák, Jitka Vostálová
Exposure to solar radiation is a major cause of environmental human skin damage. The main constituent of solar UV light is UVA radiation (320-400 nm); however, the need for protection against UVA has been marginalized for a long time. As a result, there is still a lack of useful agents for UVA protection. In this study, the effect of silymarin (SM) and its main constituent silybin (SB) pre-treatment on UVA-stimulated damage to primary human dermal fibroblasts were carried out. The cells were pre-treated for 1 h with SB or SM and then were exposed to UVA light, using a solar simulator...
March 21, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29556751/anthocyanins-from-black-soybean-seed-coat-prevent-radiation-induced-skin-fibrosis-by-downregulating-tgf-%C3%AE-and-smad3-expression
#15
Sang Woo Park, Jaehoon Choi, Junhyung Kim, Woohhyeok Jeong, Jun Sik Kim, Bae Kwon Jeong, Sung Chul Shin, Jin Hee Kim
The aim of this study was to evaluate the protective effects of anthocyanins from the black soybean seed coat against radiation injury in dermal fibroblasts and mouse skin. Dermal fibroblasts treated with 50 and 100 µg/mL anthocyanins were irradiated with single doses of 20 Gy. Cell viability, intracellular reactive oxygen species (ROS) production, and mRNA expression were measured. A total of 60 mice were used for an in vivo study. A dose of 100 µg/mL anthocyanins was administered daily for 5 days before or after radiation therapy...
March 19, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29549490/androgen-modulation-of-wnt-%C3%AE-catenin-signaling-in-androgenetic-alopecia
#16
REVIEW
A Premanand, B Reena Rajkumari
Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia...
March 16, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29497840/il-17-inhibition-is-it-the-long-awaited-savior-for-alopecia-areata
#17
REVIEW
Yuval Ramot, Barbara Marzani, Daniela Pinto, Elisabetta Sorbellini, Fabio Rinaldi
Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available information on the connection between AA and IL-17 is described. While IL-17 levels are consistently reported to be elevated in the serum and lesional skin of AA patients, there is no clear connection between IL-17 levels and disease severity or duration...
March 1, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29525907/autologous-platelet-rich-plasma-and-triamcinolone-acetonide-intralesional-injection-in-the-treatment-of-oral-erosions-of-pemphigus-vulgaris-a-pilot-study
#18
Mohamed Hussein Medhat El-Komy, Noha Adly Saleh, Marwah Adly Saleh
Oral erosions of pemphigus vulgaris (PV) represent a therapeutic challenge. In this work we compared intralesional injection of steroids (ILS) and autologous platelet-rich plasma (PRP) treatment of oral erosions of PV. In this split-mouth randomized double blind study, one side of the buccal mucosa of 11 PV patients was injected with 10 mg/ml triamcinolone and the opposite side was injected with 1 millilitre of autologous PRP every 14 days for 3 months. The percentage of clinical improvement, pemphigus disease area index and pain score were recorded before and after therapy...
May 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29476247/effects-of-topical-topiramate-in-wound-healing-in-mice
#19
Carlos Poblete Jara, Vanessa Cristina Dias Bóbbo, Rodrigo Scarpari Carraro, Thiago Matos Ferreira de Araujo, Maria H M Lima, Licio A Velloso, Eliana P Araújo
Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6.0 mm punch to create two wounds in the skin of the dorsal region. Thereafter, mice were randomly assigned to either vehicle or topical topiramate (20 µl of 2% cream) once a day for 14 days, beginning on the same day as wound generation. We analyzed the wound samples over real-time PCR, Western blotting, and microscopy...
May 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29468452/leptin-regulates-the-pro-inflammatory-response-in-human-epidermal-keratinocytes
#20
Moonyoung Lee, Eunyoung Lee, Sun Hee Jin, Sungjin Ahn, Sae On Kim, Jungmin Kim, Dalwoong Choi, Kyung-Min Lim, Seung-Taek Lee, Minsoo Noh
The role of leptin in cutaneous wound healing process has been suggested in genetically obese mouse studies. However, the molecular and cellular effects of leptin on human epidermal keratinocytes are still unclear. In this study, the whole-genome-scale microarray analysis was performed to elucidate the effect of leptin on epidermal keratinocyte functions. In the leptin-treated normal human keratinocytes (NHKs), we identified the 151 upregulated and 53 downregulated differentially expressed genes (DEGs). The gene ontology (GO) enrichment analysis with the leptin-induced DEGs suggests that leptin regulates NHKs to promote pro-inflammatory responses, extracellular matrix organization, and angiogenesis...
May 2018: Archives of Dermatological Research
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