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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/29995261/linoleate-enriched-diet-increases-both-linoleic-acid-esterified-to-omega-hydroxy-very-long-chain-fatty-acids-and-free-ceramides-of-canine-stratum-corneum-without-effect-on-protein-bound-ceramides-and-skin-barrier-function
#1
Iuliana Popa, Adrian L Watson, Audrey Solgadi, Christina Butowski, David Allaway, Jacques Portoukalian
Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on canine stratum corneum (SC) lipids was studied by feeding two groups of five dogs differential amounts of linoleic acid (LA) for three months. SC was harvested by tape stripping and lipids were analyzed by thin-layer chromatography and mass spectrometry. The dogs that were fed the higher concentration of LA showed high increases in the contents of both linoleic acid and free ceramides in the SC, whereas the protein-bound ceramide content was unchanged...
July 11, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29974194/phenotype-variability-in-tumor-disorders-of-the-skin-appendages-associated-with-mutations-in-the-cyld-gene
#2
Lizelotte J M T Parren, Kathrin Giehl, Michel van Geel, Jorge Frank
Mutations in the tumor suppressor gene CYLD underlie phenotypically heterogeneous hereditary tumor disorders of the skin appendages. These diseases are inherited autosomal dominantly and include Brooke-Spiegler syndrome (BSS; OMIM 605041), familial cylindromatosis (FC; OMIM 132700) and multiple familial trichoepithelioma (MFT; OMIM 601606). Clinically, cylindromas, trichoepitheliomas and spiradenomas can be found in affected individuals. We sought to elucidate the molecular genetic basis in individuals with newly diagnosed cylindromas, trichoepitheliomas and/or spiradenomas...
July 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29934781/how-to-weight-patient-relevant-treatment-goals-for-assessing-treatment-benefit-in-psoriasis-preference-elicitation-methods-vs-rating-scales
#3
Mandy Gutknecht, Marthe-Lisa Schaarschmidt, Marion Danner, Marina Otten, Matthias Augustin
In psoriasis, several patient-relevant treatment goals must be met to be able to consider a treatment beneficial. To assess treatment benefit, the validated questionnaire Patient Benefit Index (PBI) can be used. Its global score summarizes the degree of patient-relevant treatment goals achieved after treatment, weighted by their individual importance on rating scales. These treatment goals have empirically been assigned to five dimensions. While the weighting procedure of the PBI provides information about the importance patients attach to treatment goals on a rating scale from 0 to 4, methods of preference elicitation provide information on how patients would trade off certain treatment goals against each other...
June 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29931443/identification-of-a-novel-mutation-in-the-mechanoreceptor-encoding-gene-cxcr1-in-patients-with-keloid
#4
Qiguo Zhang, Liangqi Cai, Mian Wang, Xiaoping Ke, Xiaoyan Zhao, Yijin Huang
Keloids are skin fibroproliferative tumors characterized by locally invasive growth of fibroblasts and excessive collagen deposition. The objective of this study is to investigate the molecular basis of the keloid scar by studying the mutation of related genes. We performed gene screening of mechanoreceptors by quantitative polymerase chain reaction (qPCR), Sanger sequencing to detect the CXCR1gene mutation, and immuno-histochemistry to determine CXCR1 protein expression. Among the genes encoding mechanoreceptors, the expression of CXCR1 mRNA was significantly higher in keloid scar tissues than in the surrounding tissues of normal controls (P < 0...
June 21, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29926164/dermoscopy-of-chondrodermatitis-nodularis-helicis
#5
Begoña García-García, Pablo Munguía-Calzada, Javier Aubán-Pariente, Susana Junceda-Antuña, Pedro Zaballos, Giuseppe Argenziano, Francisco Vázquez-López
Chondrodermatitis nodularis helicis (CNH) is a benign auricular disease whose differentiation with nonpigmented tumors is mandatory. Clinical characteristics of CNH are well known, but there is no information about the dermoscopic features that could help differentiate CNH from squamous cell carcinoma and other non-melanoma skin cancers. To describe the dermoscopic appearance of CNH and to formulate a differential diagnostic model, we conducted  a retrospective, single center, observational dermoscopic study on a sample of 189 biopsy-proven lesions: 25 CNH; 26 squamous cell carcinomas; 62 basal cell carcinomas and 76 other benign and malignant tumors...
June 20, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29909529/expression-and-localization-of-vegfr-2-in-hair-follicles-during-induced-hair-growth-in-mice
#6
Xian-Jie Wu, Jing Jing, Zhong-Fa Lu, Min Zheng
Recently, VEGFR-2 has been detected not only in vascular and lymphatic endothelial cells but also in some non-vascular endothelial cells, particularly human hair follicles, sebaceous glands, and sweat glands. In addition, VEGFR-2 has been confirmed to play direct roles in hair follicle keratinocyte regulation beyond simply angiogenesis. To elucidate whether VEGFR-2 activation plays a role in hair follicle cycling regulation, immunofluorescence of VEGFR-2 expression was performed during hair cycling of the dorsum of the mouse induced by hair plucking...
June 16, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29948283/haplotypes-of-abcb1-1236c-t-rs1128503-2677g-t-a-rs2032582-and-3435c-t-rs1045642-in-patients-with-bullous-pemphigoid
#7
Mariola Rychlik-Sych, Małgorzata Barańska, Michał Dudarewicz, Jadwiga Skrętkowicz, Agnieszka Żebrowska, Anna Woźniacka, Jacek Owczarek, Daria Orszulak-Michalak, Elżbieta Waszczykowska
Bullous pemphigoid (BP) constitutes the most prevalent disease in the group of bullous dermatoses with the autoimmune background. Some authors suggest that certain cytokines (IL-2, IFN-γ) may be transported by P-glycoprotein (P-gp), the product of the ABCB1 gene. ABCB1 polymorphism might affect not only the effectiveness of treatment with drugs that are P-gp substrates but also contribute to the development of diseases, including BP. In the present work, we resolved to conduct a haplotype analysis of ABCB1 in patients with BP and to answer the question of whether any of the haplotypes are able to affect the incidence of this entity...
June 9, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29774387/ultraviolet-radiation-induces-melan-a-expressing-cells-in-interfollicular-epidermis-in-wild-type-mice
#8
David A De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch
Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice...
May 17, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29761213/can-such-an-animal-model-truly-represent-henoch-sch%C3%A3-nlein-purpura
#9
LETTER
Fengying Wang, Ruyue Chen, Xiaozhong Li, Yunyan Shen
No abstract text is available yet for this article.
May 14, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29752541/stratum-corneum-substantivity-drug-development-implications
#10
REVIEW
Becky S Li, John Havens Cary, Howard I Maibach
There are at least 15 factors that influence the ability of chemicals to penetrate the skin. Substantivity is yet another factor and allows penetrants to remain on and in skin for many days. As many skin pathologies involve stratum corneum and require multiple dosing of topicals, understanding substantivity mechanisms may provide insight for topical dosing strategies. Substantivity is also of importance in the development of other consumer products that necessitate adherence to skin, including sunscreens, insect repellents, and cosmetics...
May 11, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29737404/characterization-and-survival-of-patients-with-metastatic-basal-cell-carcinoma-in-the-department-of-veterans-affairs-a-retrospective-electronic-health-record-review
#11
Vanessa W Stevens, David D Stenehjem, Olga V Patterson, Aaron W C Kamauu, Yeun Mi Yim, Robert J Morlock, Scott L DuVall
Available descriptive statistics for patients with metastatic basal cell carcinoma (mBCC) are limited. To describe disease characteristics, treatment patterns, survival outcomes, and prognostic factors of patients with mBCC, we conducted a retrospective review of electronic health records in the Department of Veterans Affairs (VA). The primary outcome was survival. Data were also collected on demographics, comorbidities, medications, and procedures. Median (IQR) age of patients with mBCC (n = 475) was 72...
May 8, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728859/up-regulation-of-hmgb1-and-tlr4-in-skin-lesions-of-lichen-planus
#12
Gabriel Costa de Carvalho, Fabiana Yasumoto Araujo Hirata, Rosana Domingues, Cristina Adelaide Figueiredo, Mariana Colombini Zaniboni, Naiura Vieira Pereira, Mirian Nacagami Sotto, Valéria Aoki, Alberto José da Silva Duarte, Maria Notomi Sato
Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns) may also contribute to the inflammatory response in LP. HMGB1 (high mobility group box 1 protein) is one of the major DAMPs that induces inflammation and could trigger LP disease. The present study was aimed to examine TLR4, RAGE and HMGB1 production in epidermis or dermis by immunohistochemistry and the respective expression of these targets in the skin lesions of patients with LP...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728858/amelioration-of-lactic-acid-sensations-in-sensitive-skin-by-stimulating-the-barrier-function-and-improving-the-ceramide-profile
#13
Hiroshi Nojiri, Koichi Ishida, Xueqiu Yao, Wei Liu, Genji Imokawa
We determined whether compensating ceramides in the stratum corneum (SC) may ameliorate the impaired barrier function and subsequently attenuate the enhanced skin sensitivity. Treatment for 4 weeks with the ceramide complex cream or the placebo cream significantly ameliorated the intensity of lactic acid sensations in 39 female subjects with sensitive skin, the degree of which was attenuated to a greater extent at 1 week by the ceramide complex cream compared with the placebo cream. The amelioration of skin sensations was accompanied by a significant increase in total ceramide content in the SC elicited by the ceramide complex cream that was significantly more effective than the placebo cream at 4 weeks...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29728857/cxcl13-is-an-activity-marker-for-systemic-but-not-cutaneous-lupus-erythematosus-a-longitudinal-cohort-study
#14
Anna Niederkorn, Julia Frühauf, Gerold Schwantzer, Nora Wutte, Clemens Painsi, Stefan Werner, Martin Stradner, Andrea Berghold, Josef Hermann, Elisabeth Aberer
Serum levels of the IFN-regulated cytokine CXCL13 have been found to correlate with SLEDAI and renal involvement in systemic lupus erythematosus. This study investigates whether CXCL13 can also be a marker of disease activity in patients with subacute cutaneous or chronic cutaneous lupus erythematosus (SCLE, CCLE). We analysed CXCL13 levels in 60 patients' sera (18 SLE, 19 SCLE, 23 CCLE) at five time points within 1 year and correlated these levels with disease activity scores and laboratory markers. Clinical scores with no/mild, moderate or high/severe disease activity were categorized by SLEDAI in SLE, by CLASI in SCLE/CCLE...
May 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29687328/determinants-of-quality-of-life-and-psychological-status-in-adults-with-psoriasis
#15
Zhenli Kwan, Yii Bonn Bong, Leng Leng Tan, Shu Xian Lim, Adrian Sze Wai Yong, Chin Chwen Ch'ng, Maw Pin Tan, Rokiah Ismail
We investigated whether disease severity and clinical manifestations were associated with depression, anxiety, stress and quality of life in adults with psoriasis. Participants were recruited from a dermatology outpatient clinic at a teaching hospital. Information on sociodemographic characteristics, disease severity, presence of arthropathy and head involvement was specifically recorded. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Quality of life and psychological symptoms were measured using the Dermatology Life Quality Index (DLQI) and the Depression Anxiety Stress Scale (DASS), respectively...
April 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29858696/reply-to-the-letter-can-such-an-animal-model-truly-represent-henoch-sch%C3%A3-nlein-purpura
#16
LETTER
Yanhong Li, Xiaolong Sui, Hua Zhu, Yanfeng Xu, Lan Huang, Yuhuan Xu, Yunlin Han, Xiaochun Feng, Chuan Qin
No abstract text is available yet for this article.
August 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29725758/ex-vivo-nonlinear-microscopy-imaging-of-ehlers-danlos-syndrome-affected-skin
#17
Norbert Kiss, Dóra Haluszka, Kende Lőrincz, Enikő Kuroli, Judit Hársing, Balázs Mayer, Sarolta Kárpáti, György Fekete, Róbert Szipőcs, Norbert Wikonkál, Márta Medvecz
Ehlers-Danlos syndrome (EDS) is the name for a heterogenous group of rare genetic connective tissue disorders with an overall incidence of 1 in 5000. The histological characteristics of EDS have been previously described in detail in the late 1970s and early 1980s. Since that time, the classification of EDS has undergone significant changes, yet the description of the histological features of collagen morphology in different EDS subtypes has endured the test of time. Nonlinear microscopy techniques can be utilized for non-invasive in vivo label-free imaging of the skin...
July 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29704126/dermal-white-adipose-tissue-undergoes-major-morphological-changes-during-the-spontaneous-and-induced-murine-hair-follicle-cycling-a-reappraisal
#18
April R Foster, Carina Nicu, Marlon R Schneider, Eleanor Hinde, Ralf Paus
In murine skin, dermal white adipose tissue (DWAT) undergoes major changes in thickness in synchrony with the hair cycle (HC); however, the underlying mechanisms remain unclear. We sought to elucidate whether increased DWAT thickness during anagen is mediated by adipocyte hypertrophy or adipogenesis, and whether lipolysis or apoptosis can explain the decreased DWAT thickness during catagen. In addition, we compared HC-associated DWAT changes between spontaneous and depilation-induced hair follicle (HF) cycling to distinguish between spontaneous and HF trauma-induced events...
July 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29525907/autologous-platelet-rich-plasma-and-triamcinolone-acetonide-intralesional-injection-in-the-treatment-of-oral-erosions-of-pemphigus-vulgaris-a-pilot-study
#19
Mohamed Hussein Medhat El-Komy, Noha Adly Saleh, Marwah Adly Saleh
Oral erosions of pemphigus vulgaris (PV) represent a therapeutic challenge. In this work we compared intralesional injection of steroids (ILS) and autologous platelet-rich plasma (PRP) treatment of oral erosions of PV. In this split-mouth randomized double blind study, one side of the buccal mucosa of 11 PV patients was injected with 10 mg/ml triamcinolone and the opposite side was injected with 1 millilitre of autologous PRP every 14 days for 3 months. The percentage of clinical improvement, pemphigus disease area index and pain score were recorded before and after therapy...
May 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29476247/effects-of-topical-topiramate-in-wound-healing-in-mice
#20
Carlos Poblete Jara, Vanessa Cristina Dias Bóbbo, Rodrigo Scarpari Carraro, Thiago Matos Ferreira de Araujo, Maria H M Lima, Licio A Velloso, Eliana P Araújo
Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6.0 mm punch to create two wounds in the skin of the dorsal region. Thereafter, mice were randomly assigned to either vehicle or topical topiramate (20 µl of 2% cream) once a day for 14 days, beginning on the same day as wound generation. We analyzed the wound samples over real-time PCR, Western blotting, and microscopy...
May 2018: Archives of Dermatological Research
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