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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/28213804/psoriasis-and-cardiovascular-events-updating-the-evidence
#1
Line Raaby, Ole Ahlehoff, Annette de Thurah
So far, systematic reviews have suggested an increased risk of cardiovascular diseases (CVD) in psoriatic patients, though some results have been conflicting. The aim of this study was to update the current level of evidence through a systematic search in MEDLINE, EMBASE and Cochrane Central Register databases. In total, 13 high-quality observational studies estimating the incidence of CVD were included. Patients with mild psoriasis had an increased risk of stroke [Hazard ratio (HR) = 1.10, 95% CI: 1.0-1...
February 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28197761/the-pigment-epithelium-derived-factor-pedf-an-important-potential-therapeutic-agent-for-infantile-hemangioma
#2
Ming Li, Yanru Chen, Zhihui Guo, Yide Xie, Yakuan Zhou, Chenghong Jiang, Xiaosong Chen
In previous studies, the expression and the role of proangiogenic factors in infantile hemangiomas have been well studied. However, the role of angiogenic inhibitors has been revealed rarely. The expression of PEDF, as the strongest and safe endogenous inhibitor, is still unrecognized until the current study. In order to investigate the expression and significance of the pigment epithelium-derived factor (PEDF) in the proliferating and regressing phases of infantile hemangiomas, the expression of PEDF, VEGF, Ki-67, and CD34 protein in hemangioma tissues was examined with immunohistochemical polymer HRP method in 42 cases during the proliferative phase, 40 cases during the regressing phase, and 11 cases of non-involuting congenital hemangiomas (NICHs)...
February 14, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28185012/the-synergistic-effect-of-maltose-enhances-the-anti-melanogenic-activity-of-acarbose
#3
Bum-Ho Bin, Sung Tae Kim, Jinhyuk Bhin, Kyounghee Byoun, Tae Ryong Lee, Eun-Gyung Cho
Melanocytes play an important role in maintaining epidermal homeostasis by producing melanin and protecting the skin from harmful environmental factors. However, excessive up- or down-regulation of melanin production often causes hyper- or hypo-pigmented disorders, respectively, which affect the patient's quality of life. Therefore, various strategies for modulating melanin levels have been developed by the pharmaceutical and cosmetic industries. We reported previously that voglibose, which is a well-known anti-hyperglycemic agent, could be used as an anti-melanogenic agent by inhibiting α-glucosidase activity and reducing tyrosinase protein levels...
February 9, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28180934/measuring-acne-using-coproporphyrin-iii-protoporphyrin-ix-and-lesion-specific-inflammation-an-exploratory-study
#4
Sachin V Patwardhan, C Richter, A Vogt, U Blume-Peytavi, D Canfield, J Kottner
Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. acnes. In this exploratory study, for the first time, the possible relationships of Coproporphyrin III (CpIII) and Protoporphyrin IX (PpIX) fluorescence as well as acne lesion-specific inflammation measurements with clinical signs of acne are investigated...
February 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28180933/voluntary-exercise-improves-murine-dermal-connective-tissue-status-in-high-fat-diet-induced-obesity
#5
Kende Lőrincz, Dóra Haluszka, Norbert Kiss, Nóra Gyöngyösi, András Bánvölgyi, Róbert Szipőcs, Norbert M Wikonkál
Obesity is a risk factor for several cardiovascular and metabolic diseases. Its influence on the skin is less obvious, yet certain negative effects of adipose tissue inflammation on the dermis have been suggested. Excess weight is closely associated with sedentary behavior, so any increase in physical activity is considered beneficial against obesity. To investigate the effects of obesity and physical exercise on the skin, we established a mouse model in which mice were kept either on a high-fat diet or received standard chow...
February 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28084540/peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-contributes-to-control-of-melanogenesis-in-b16-f10-melanoma-cells
#6
Maja Grabacka, Justyna Wieczorek, Dominika Michalczyk-Wetula, Michel Malinowski, Norbert Wolan, Katarzyna Wojcik, Przemyslaw M Plonka
Recent studies revealed the cooperation between peroxisome proliferator-activated receptor gamma (PPARγ) and α-MSH signaling, which results in enhanced melanogenesis in melanocytes and melanoma cells. However, the agonists of PPARα, such as fenofibrate, exert depigmenting effect. Therefore, we aimed to check how the PPARα expression level affects the antimelanogenic activity of fenofibrate and whether PPARα modulates melanogenesis independently of its agonist. To answer these questions, we used three B16 F10-derived cell lines, which varied in the PPARα expression level and were developed by stable transfection with plasmids driving shRNA-based PPARα silencing or overexpression of PPARα-emerald GFP fusion protein...
January 13, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28078437/senescence-in-the-lesional-fibroblasts-of-non-segmental-vitiligo-patients
#7
Seema Rani, Supriya Bhardwaj, Niharika Srivastava, Vijay Lakshmi Sharma, Davinder Parsad, Ravinder Kumar
Dermal fibroblasts secrete various growth factors which are important for skin pigmentation. Imbalance in the synchronization of epidermal and dermal cells in the skin can play vital role in the pathogenesis of pigmentary disorder vitiligo. Therefore, our objective was to check the lesional fibroblasts for any abnormality and senescence in non-segmental vitiligo patients (NSV). Skin punch biopsies were taken from NSV patients and healthy controls. Explant culture of fibroblast from lesional dermis, non-lesional dermis, and control was analyzed...
January 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28013372/mir-21-and-mir-205-are-induced-in-invasive-cutaneous-squamous-cell-carcinomas
#8
Olivera Stojadinovic, Horacio Ramirez, Irena Pastar, Katherine A Gordon, Rivka Stone, Sonal Choudhary, Evangelos Badiavas, Keyvan Nouri, Marjana Tomic-Canic
Cutaneous squamous cell carcinoma (cSCC) is a malignant proliferation of keratinocytes with an uncertain molecular basis causing significant morbidity. MicroRNAs (miRs) are small RNA molecules that regulate gene expression on post- transcriptional level. MiRs are critical to various biological processes. To determine if miRs play a role in pathogenesis of invasive cSCC, we collected patients' specimens from in situ and invasive cSCC (n = 19) and examined miRs expression levels using qPCR. Specifically, we evaluated miR-21, miR-103a, miR-186, miR-200b, miR-203, and miR-205 expression levels due to their role in skin biology and epithelial to mesenchymal transition...
December 24, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28004279/in-vitro-cultured-fetal-fibroblasts-have-myofibroblast-associated-characteristics-and-produce-a-fibrotic-like-environment-upon-stimulation-with-tgf-%C3%AE-1-is-there-a-thin-line-between-fetal-scarless-healing-and-fibrosis
#9
M Walraven, J J Akershoek, R H J Beelen, M M W Ulrich
Transforming growth factor-β (TGF-β) is a cytokine occurring in three isoforms with an important function in development and wound healing. In wound healing, prolonged TGF-β signaling results in myofibroblast differentiation and fibrosis. In contrast, the developing second-trimester fetal skin contains high levels of all three TGF-β isoforms but still has the intrinsic capacity to heal without scarring. Insight into TGF-β signal transduction during fetal wound healing might lead to methods to control the signaling pathway during adult wound healing...
December 21, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27988894/increase-in-circulating-sphingosine-1-phosphate-and-decrease-in-ceramide-levels-in-psoriatic-patients
#10
Hanna Myśliwiec, Anna Baran, Ewa Harasim-Symbor, Barbara Choromańska, Piotr Myśliwiec, Anna Justyna Milewska, Adrian Chabowski, Iwona Flisiak
Psoriasis is characterized by hyperproliferation, deregulated differentiation and impaired apoptosis of keratinocytes. Mechanisms of lipid profile disturbances and metabolic syndrome in the psoriatic patients are still not fully understood. Sphingolipids, namely ceramides (CER) and sphingosine-1-phosphate (S1P) are signal molecules which can regulate cell growth, apoptosis and immune reactions. The aim of the study was to evaluate circulating CER and S1P levels in plaque-type psoriasis and their associations with the disease activity, inflammatory or metabolic markers and the presence of psoriatic comorbidities...
December 17, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27988893/n-acetylglutaminoyl-s-farnesyl-l-cysteine-sig-1191-an-anti-inflammatory-molecule-that-increases-the-expression-of-the-aquaglyceroporin-aquaporin-3-in-human-keratinocytes
#11
José R Fernández, Corey Webb, Karl Rouzard, Michael Voronkov, Kristen L Huber, Jeffry B Stock, Maxwell Stock, Joel S Gordon, Eduardo Perez
Isoprenylcysteine (IPC) small molecules were discovered as signal transduction modulating compounds ~25 years ago. More recently, IPC molecules have demonstrated antioxidant and anti-inflammatory properties in a variety of dermal cells as well as antimicrobial activity, representing a novel class of compounds to ameliorate skin conditions and disease. Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production...
December 17, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27988892/immunolocalization-of-substance-p-and-nk-1-receptor-in-vascular-anomalies
#12
Alejandro Ortiz-Prieto, José Bernabeu-Wittel, Teresa Zulueta-Dorado, Ana I Lorente-Lavirgen, Miguel Muñoz
The peptide substance P (SP) shows a widespread distribution in both the central and peripheral nervous systems, but it is also ubiquitous in the human body. After binding to the neurokinin-1 (NK-1) receptor, SP regulates tumoral angiogenesis and proliferation. Thus, knowledge of this system is the key for a better understanding and, hence, a better management of many human diseases, including vascular anomalies (VA). This study aims to examine the expression and localization of both SP and the NK-1 receptor in different vascular anomalies using an immunohistochemical technique...
December 17, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27988891/investigation-of-36-non-hla-human-leucocyte-antigen-psoriasis-susceptibility-loci-in-a-psoriatic-arthritis-cohort
#13
Zheng Zhang, Jin Yuan, Zhen Tian, Jinhua Xu, Zhong Lu
Psoriasis has been intensively studied recently and numerous risk-associated variants within 44 susceptibility loci have been discovered. Estimates suggest that the genetic contribution to PsA (psoriatic arthritis) may be higher than PsV (psoriasis vulgaris) yet most work has been done on the latter due to its greater population prevalence. To test whether variants in the PsV-associated loci are also related to PsA, we performed a candidate loci association study in Chinese population. Genotyping was performed by MassARRAY platform (Sequenom, San Diego, CA, USA)...
December 17, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27928683/specific-autoantibodies-in-dermatomyositis-a-helpful-tool-to-classify-different-clinical-subsets
#14
Giulia Merlo, Andrea Clapasson, Emanuele Cozzani, Luigi Sanna, Giampaola Pesce, Marcello Bagnasco, Martina Burlando, Aurora Parodi
Autoantibodies are important in the diagnosis of dermatomyositis. They can be divided in two different groups: myositis-associated autoantibodies (MAA) prevailing in overlap syndromes, and myositis-specific autoantibodies (MSA), with diagnostic specificity exceeding 90%. Our purpose was to detect retrospectively the prevalence of the most common MSAs in a group of 19 adult DM patients (13 women, 6 men). A severe DM (SDM), with extensive cutaneous and muscular manifestations, dysphagia, and sometimes pneumopathy, was detected in ten cases...
December 7, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27942931/3d-modeling-of-keloid-scars-in-vitro-by-cell-and-tissue-engineering
#15
Dutsadee Suttho, Samlee Mankhetkorn, Delphine Binda, Lionel Pazart, Philippe Humbert, Gwenaël Rolin
Keloids are pathologic scars defined as dermal fibrotic tumors resulting from a disturbance of skin wound healing process. Treatments against keloids are multiple, sometimes empirical and none of them really provides an effective tool for physicians. The lack of effective treatments is correlated with the poor understanding of keloid pathogenesis. To fill this gap, researchers need strong models mimicking keloids as closely as possible. The objective of this study was to establish in vitro a new reconstructed keloid model (RKM), by combining fibroblasts extracted from the three major area of a keloid (center, periphery, non-lesional) in a three-dimensional biomaterial...
January 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27885419/ketoconazole-inhibits-malassezia-furfur-morphogenesis-in-vitro-under-filamentation-optimized-conditions
#16
Sirida Youngchim, Joshua D Nosanchuk, Siriporn Chongkae, Nongnuch Vanittanokom
Malassezia furfur, a constituent of the normal human skin flora, is an etiological agent of pityriasis versicolor, which represents one of the most common human skin diseases. Under certain conditions, both exogenous and endogenous, the fungus can transition from a yeast form to a pathogenic mycelial form. To develop a standardized medium for reproducible production of the mycelial form of M. furfur to develop and optimize susceptibility testing for this pathogen, we examined and characterized variables, including kojic acid and glycine concentration, agar percentage, and pH, to generate a chemically defined minimal medium on which specific inoculums of M...
January 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27878387/genetic-susceptibility-to-cutaneous-radiation-injury
#17
REVIEW
Amy Huang, Sharon A Glick
The use of ionizing radiation is critical to cancer treatment and fluoroscopic procedures. However, despite efforts to minimize total radiation dose, many patients experience toxic cutaneous side-effects of ionizing radiation, ranging from mild erythema to subcutaneous fibrosis, telangiectasia formation, and ulceration. Extent of injury is highly variable among patients. Studying the genetic determinants of radiation injury can help develop protocols to reduce radiation toxicity, as well as drive research into effective modulators of the genes and gene products associated with radiation injury...
January 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27864629/cytokeratin-ae1-ae3-immunostaining-and-3d-histology-improvement-of-diagnosis-in-desmoplastic-squamous-cell-carcinoma-of-the-skin
#18
Katrin Schweinzer, Lukas Kofler, Jürgen Bauer, Gisela Metzler, Helmut Breuninger, Hans-Martin Häfner
Desmoplastic squamous cell carcinoma (DSCC) as a rare subtype of cutaneous SCC has specific histological features, characterized by columns, bands, and strands of squamoid cells infiltrating a dense collagenous stroma. To decrease the high rates of local recurrence in DSSC, improvement of diagnostic methods is highly demanded. Objective was to evaluate whether immunohistochemistry (IHC) is suited to increase diagnostic accuracy. A total number of 18 patients were included in this study. After recutting of the original paraffin blocks, parallel staining of serial sections with conventionally H&E and cytokeratin AE1/AE3-immunohistochemical staining was performed...
January 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27833999/methyl-%C3%AE-cyclodextrin-treatment-combined-to-incubation-with-interleukin-4-reproduces-major-features-of-atopic-dermatitis-in-a-3d-culture-model
#19
Tatiana do Nascimento Pedrosa, Evelyne De Vuyst, Abdallah Mound, Catherine Lambert de Rouvroit, Silvya Stuchi Maria-Engler, Yves Poumay
Atopic dermatitis (AD) skin is characterized by over-expression of interleukin (IL)-4, IL-13 and IL-25. When methyl-β-cyclodextrin (MβCD) treatment preceded exposure to these interleukins, combination of both treatments was found to mimic hallmarks of AD in vitro, such as barrier weakening, histological alterations and typical signaling responses in a reconstructed human epidermis (RHE). However, the respective role of each IL and whether any of them is critical when combined with MβCD treatment was unknown...
January 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27783153/epidermal-hydrogen-peroxide-is-not-increased-in-lesional-and-non-lesional-skin-of-vitiligo
#20
Mohammad Z Zailaie
It is widely believed that the loss of the epidermal melanocytes in vitiligo is basically due to excessive oxidative stress. Previous research work described abnormal elevation of the absolute concentration of the epidermal hydrogen peroxide (H2O2) in lesional and non-lesional skin of vitiligo. Based on this finding, our primary research objective was to use this feature as a screening marker in individuals at a great risk of developing vitiligo. Ninety-six patients of non-segmental vitiligo (NSV) of varying durations, skin phototypes, and treatment modalities (psoralen UVA-, narrow band UVB-treated) were recruited for this study...
January 2017: Archives of Dermatological Research
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