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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/30617657/ameliorative-effects-of-green-tea-extract-from-tannase-digests-on-house-dust-mite-antigen-induced-atopic-dermatitis-like-lesions-in-nc-nga-mice
#1
YeonSil Hwang, BoYoon Chang, TaeYoung Kim, SungYeon Kim
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases, which is affected by several factors. Anti-histamines, steroids, and immunosuppressive agents have been used for the treatment of AD. However, many studies have reported that long-term use and abuse of these drugs causes many side effects. This study was performed to evaluate the ameliorative effect of green tea extract on AD-like lesions in NC/Nga mice. Green tea extract from tannase digest (GTT), beta-hexosaminidase, and histamine were measured in IgE-antigen complex-stimulated RBL-2H3 cells...
January 7, 2019: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30547366/pushing-and-loss-of-elastic-fibers-are-highly-specific-for-melanoma-and-rare-in-melanocytic-nevi
#2
A Stillhard, S Cazzaniga, L Borradori, Helmut Beltraminelli
The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. In a monocentric retrospective study we have analyzed 14 morphological histological characteristics in 30 MMs and 90 nevi, encompassing 30 compound/dermal nevi, 30 junctional nevi, 30 dysplastic nevi...
December 13, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30515575/downregulation-of-aquaporin-3-in-bullous-pemphigoid-patients
#3
Mona Mostafa Korany, Marwa Ahmed Amer, Laila Ahmed Rashed, Marwah Adly Saleh
Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Perilesional skin biopsies were taken from 24 BP patients and 13 controls. The biopsies were stained by direct immunofluorescence using rabbit anti-human AQP 3 FITC antibody. The expression of AQP 3 was weak in 5 patients (20.8%), moderate in 18 patients (75%), strong in 1 patient (4.2%) in the suprabasal layers...
December 4, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30511160/leakage-of-sweat-into-the-dermo-epidermal-junction-as-a-possible-trigger-for-lichen-planus-lesion-development
#4
Yoshiko Mizukawa, Yoshimi Yamazaki, Tetsuo Shiohara
No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), which allows accurate quantification of individual sweat glands/ducts actively delivering sweat in a well-defined location, to evaluate sweating disturbance in LP lesions. Psoriasis vulgaris (PsV) lesions were included as controls...
December 3, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30506422/comparing-early-and-late-treatments-with-rituximab-in-pemphigus-vulgaris-which-one-is-better
#5
Kamran Balighi, Maryam Daneshpazhooh, HamidReza Mahmoudi, Mehrnoosh Badakhsh, Amir Teimourpour, Amir Houshang Ehsani, Arghavan Azizpour, Zahra Akbari, Mostafa Mahdavinia, Mojtaba Ghasemiadl, Soheil Tavakolpour
During the last decade, successfully treatment of patients diagnosed with pemphigus vulgaris (PV) with rituximab (RTX) was reported by several authors. The present study has been designed to compare the clinical outcomes and RTX-related side effects between the two groups of early treated (≤ 6 months) and lately treated PV (> 6 months) patients with RTX. We did a retrospective study between Oct 2014 and Jun 2016 to compare the short-term efficacy and safety of RTX in PV diagnosed patients. The primary and secondary endpoints were complete/partial remission of disease and safely tapering of corticosteroids without disease relapse, respectively...
December 1, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30506356/ameliorating-effect-of-dipotassium-glycyrrhizinate-on-an-il-4-and-il-13-induced-atopic-dermatitis-like-skin-equivalent-model
#6
Sung Hoon Lee, Il-Hong Bae, Hyangtae Choi, Hyeong Won Choi, Soojung Oh, Paulo A Marinho, Dae Jin Min, Dae-Yong Kim, Tae Ryong Lee, Chang Seok Lee, Jongsung Lee
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is not fully understood. Defects in skin barrier function and dysregulation of the Th2 immune response are thought to be pivotal in AD pathogenesis. In this study, we used keratinocytes and AD-like skin equivalent models using Th2 cytokines IL-4 and IL-13. The keratinocytes and AD-like skin model were used to investigate the effect of dipotassium glycyrrhizinate (KG), which is widely used as an anti-inflammatory agent for AD treatment. KG decreased AD-related gene expression in keratinocytes stimulated with Th2 cytokines...
November 30, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30483878/cxcl12-regulates-differentiation-of-human-immature-melanocyte-precursors-as-well-as-their-migration
#7
Takaaki Yamada, Seiji Hasegawa, Yuichi Hasebe, Mika Kawagishi-Hotta, Masaru Arima, Yohei Iwata, Tsukane Kobayashi, Shigeki Numata, Naoki Yamamoto, Satoru Nakata, Kazumitsu Sugiura, Hirohiko Akamatsu
Melanocyte stem cells (McSCs) are localized in the bulge region of hair follicles and supply melanocytes, which determine hair color by synthesizing melanin. Ectopic differentiation of McSCs, which are usually undifferentiated in the bulge region, causes depletion of McSCs and results in hair graying. Therefore, to prevent hair graying, it is essential to maintain McSCs in the bulge region, but the mechanism of McSC maintenance remains unclear. To address this issue, we investigated the role of CXCL12, a chemokine which was previously suggested to induce migration of melanocyte lineage cells, as a niche component of McSCs...
November 27, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30483877/the-role-of-pi3k-akt-foxo-signaling-in-psoriasis
#8
REVIEW
Miao Zhang, Xiaoyan Zhang
Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathway play a central role in multiple cellular functions such as cell proliferation and survival. The forkhead box O (FOXO) transcription factors are negatively regulated by the PI3K/AKT signaling pathway and considered to have inhibitory effect on cell proliferation. Psoriasis is a multifactorial disease with a strong genetic background and characterized by hyperproliferative keratinocyte. PI3K signaling regulates proliferation of keratinocyte by activating AKT and other targets, and by inducing FOXO downregulation...
November 27, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30460511/podoplanin-suppresses-the-cell-adhesion-of-epidermal-keratinocytes-via-functional-regulation-of-%C3%AE-1-integrin
#9
Takashi Shibuya, Masaru Honma, Mizue Fujii, Shin Iinuma, Akemi Ishida-Yamamoto
Epidermal stem cells adhere more efficiently to the extracellular matrix (ECM) than the less adhesive differentiating cells due to their high expression of cell adhesion molecules including β1-integrin. Podoplanin is majorly expressed in the markedly proliferative and differentiating basal cells of the wounded and psoriatic epidermis. This study was designed to reveal podoplanin's function in human epidermal keratinocytes (HEK) focusing on its interaction with β1-integrin. We analyzed the adhesion and differentiation of HEK in both podoplanin-overexpressing and -knock-down cells, considering their β1-integrin levels...
November 20, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30460510/evidence-of-proliferative-activity-in-human-merkel-cells-implications-in-the-histogenesis-of-merkel-cell-carcinoma
#10
Yutaka Narisawa, Takuya Inoue, Kotaro Nagase
The cellular origin of Merkel cell carcinoma (MCC) is controversial. We previously hypothesized that MCC originates from hair follicle stem cells or Merkel cell (MC) progenitors residing within the hair follicle bulge. Examination of three cases of combined MCC led to the unexpected discovery that numerous keratin 20 (CK20)-positive MCs within the squamous cell carcinoma (SCC) component of combined MCC appeared morphologically normal with dendritic and oval shapes. Moreover, one extremely rare case of combined SCC and MCC showed both intra-epidermal and dermal MCCs...
November 20, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30390113/gene-expression-analysis-of-antimony-resistance-in-leishmania-tropica-using-quantitative-real-time-pcr-focused-on-genes-involved-in-trypanothione-metabolism-and-drug-transport
#11
Mehdi Mohebali, Elham Kazemirad, Homa Hajjaran, Elaheh Kazemirad, Mohammad Ali Oshaghi, Reza Raoofian, Aref Teimouri
Pentavalent antimonials remain the treatment of choice for all the clinical forms of leishmaniasis. The increasing rates of antimony resistance are becoming a serious health problem in treatment of anthroponotic cutaneous leishmaniasis (ACL). Accordingly, unraveling molecular markers is crucial for improving medication strategies and monitoring of drug-resistant parasites. Different studies have suggested the importance of genes involved in trypanothione metabolism and drug transport. In this regard, present study was designed to investigate the RNA expression level of five genes including γ-GCS, ODC, TRYR (involved in trypanothione metabolism), AQP1 (acts in drug uptake) and MRPA (involved in sequestration of drug) in sensitive and resistant Leishmania tropica isolates...
November 2, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30382340/mortality-and-risk-factors-among-israeli-bullous-pemphigoid-patients
#12
Mati Rozenblat, Awad Halaj, Tal Rozenblat, Shani Fisher, Mohammad Sah, Roni P Dodiuk-Gad, Michael Ziv
There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Mean survival period of the BP group was 4.1 years (95% CI: 3.3-4.8 years) and 5.9 years among the non-BP group (95% CI: 5...
October 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30382339/small-intestinal-bacterial-overgrowth-in-systemic-sclerosis-a-review-of-the-literature
#13
REVIEW
Beata Polkowska-Pruszyńska, Agnieszka Gerkowicz, Paulina Szczepanik-Kułak, Dorota Krasowska
Systemic sclerosis (SSc) is a chronic, connective tissue disease with an autoimmune pattern characterized by inflammation, fibrosis and microcirculation changes leading to internal organs malfunctions. Recently, the presence of uncharacteristic gastrointestinal symptoms in the course of SSc has been underlined. The possible cause of such clinical presentation is the small intestinal bacterial overgrowth (SIBO). Nevertheless, these manifestations resulting from gastrointestinal tract hypomotility may occur in numerous disease entities...
October 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30370495/reconstructed-human-keloid-models-show-heterogeneity-within-keloid-scars
#14
Grace C Limandjaja, Leonarda J van den Broek, Taco Waaijman, Melanie Breetveld, Stan Monstrey, Rik J Scheper, Frank B Niessen, Susan Gibbs
Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions...
October 28, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30417279/a-randomized-placebo-controlled-single-center-pilot-study-of-the-safety-and-efficacy-of-apremilast-in-subjects-with-moderate-to-severe-alopecia-areata
#15
Daniela Mikhaylov, Ana Pavel, Christopher Yao, Grace Kimmel, John Nia, Peter Hashim, Anjali S Vekaria, Mark Taliercio, Giselle Singer, Rachel Karalekas, Danielle Baum, Yasaman Mansouri, Mark G Lebwohl, Emma Guttman-Yassky
Alopecia areata (AA) is a common autoimmune disease that results in non-scarring hair loss. AA pathogenesis is thought to involve multiple inflammatory cytokines. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that reduces pro-inflammatory cytokine production. Recent studies demonstrate upregulation of PDE4 in human scalp lesions of AA patients and hair regrowth in a humanized AA mouse model upon apremilast treatment, suggesting a possible potential of apremilast in AA. To assess the efficacy and safety of apremilast in AA, we conducted a double-blind, placebo-controlled single-center pilot study in 30 moderate-to-severe AA patients (≥ 50% scalp involvement) that were randomized 2:1 to receive apremilast (n = 20) or placebo (n = 10) orally for 24 weeks...
January 2019: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30293125/visfatin-and-insulin-levels-and-cigarette-smoking-are-independent-risk-factors-for-hidradenitis-suppurativa-a-case-control-study
#16
Neslihan Akdogan, Nuran Alli, Pinar Incel Uysal, Canan Topcuoglu, Tuba Candar, Turan Turhan
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS...
December 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30250964/systematic-review-of-mobile-phone-based-teledermatology
#17
REVIEW
Ashley K Clark, Suzana Bosanac, Baran Ho, Raja K Sivamani
Teledermatology is an expanding field within dermatology that has grown and become more clinically accepted by both patients and doctors. With approximately 260 million mobile phone users in the US and 4-6 billion worldwide with access to mobile phones, teledermatology serves as a potentially useful tool for diagnosis and management (Samkange-Zeeb and Blettner in Emerg Health Threats J, https://doi.org/10.3134/ehtj.09.005 , 2009). In this review, we provide a detailed overview of mobile phone technology and the accumulating evidence for its incorporation into dermatology...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30182275/age-related-and-seasonal-changes-in-covalently-bound-ceramide-content-in-forearm-stratum-corneum-of-japanese-subjects-determination-of-molecular-species-of-ceramides
#18
Anna Fujiwara, Masashi Morifuji, Masami Kitade, Keiko Kawahata, Tomoyuki Fukasawa, Taketo Yamaji, Hiroyuki Itoh, Makoto Kawashima
The stratum corneum (SC) consists of corneocytes surrounded by a neutral lipid-enriched intercellular matrix. Ceramides represent approximately 50% of intercellular lipids, and play important roles in retaining epidermal water. The SC also contains covalently bound ceramides, which are thought to play a crucial role in the formation of lamellar structures, and are involved in maintaining skin barrier function. A previous report showed that levels of free ceramides in human SC changed with the seasons and age, although whether the content of different species of covalently bound ceramides also underwent such temporal changes was unclear...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30171347/comprehensive-assessment-of-the-association-between-genes-on-jak-stat-pathway-ifih1-tyk2-il-10-and-systemic-lupus-erythematosus-a-meta-analysis
#19
Qiong Yin, Liang-Cai Wu, Lu Zheng, Ming-Yu Han, Li-Ya Hu, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jiang-Wei Xia, Xiao-Bo Wang, Xing-Wei Zhang, Hou-Feng Zheng
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167814/achieving-international-consensus-on-the-assessment-of-psoriatic-arthritis-in-psoriasis-clinical-trials-an-international-dermatology-outcome-measures-ideom-initiative
#20
Lourdes Maria Perez-Chada, Jeffrey M Cohen, Alice Bendix Gottlieb, Kristina Callis Duffin, Amit Garg, John Latella, April Wang Armstrong, Alexis Ogdie, Joseph Frank Merola
Psoriatic arthritis (PsA) is rarely assessed in psoriasis randomized controlled trials (RCT); thus, the effect of psoriasis therapy on PsA is unknown. The International Dermatology Outcome Measures (IDEOM) has included "PsA Symptoms" as part of the core domains to be measured in psoriasis RCT. This study aimed to achieve consensus about screening for PsA and how to measure for "PsA Symptoms" in psoriasis RCT. At the IDEOM 2017 Annual Meeting, stakeholders voted on the role of PsA screening in psoriasis RCT...
November 2018: Archives of Dermatological Research
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