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Archives of Dermatological Research

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https://www.readbyqxmd.com/read/30390113/gene-expression-analysis-of-antimony-resistance-in-leishmania-tropica-using-quantitative-real-time-pcr-focused-on-genes-involved-in-trypanothione-metabolism-and-drug-transport
#1
Mehdi Mohebali, Elham Kazemirad, Homa Hajjaran, Elaheh Kazemirad, Mohammad Ali Oshaghi, Reza Raoofian, Aref Teimouri
Pentavalent antimonials remain the treatment of choice for all the clinical forms of leishmaniasis. The increasing rates of antimony resistance are becoming a serious health problem in treatment of anthroponotic cutaneous leishmaniasis (ACL). Accordingly, unraveling molecular markers is crucial for improving medication strategies and monitoring of drug-resistant parasites. Different studies have suggested the importance of genes involved in trypanothione metabolism and drug transport. In this regard, present study was designed to investigate the RNA expression level of five genes including γ-GCS, ODC, TRYR (involved in trypanothione metabolism), AQP1 (acts in drug uptake) and MRPA (involved in sequestration of drug) in sensitive and resistant Leishmania tropica isolates...
November 2, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30382340/mortality-and-risk-factors-among-israeli-bullous-pemphigoid-patients
#2
Mati Rozenblat, Awad Halaj, Tal Rozenblat, Shani Fisher, Mohammad Sah, Roni P Dodiuk-Gad, Michael Ziv
There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Mean survival period of the BP group was 4.1 years (95% CI: 3.3-4.8 years) and 5.9 years among the non-BP group (95% CI: 5...
October 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30382339/small-intestinal-bacterial-overgrowth-in-systemic-sclerosis-a-review-of-the-literature
#3
REVIEW
Beata Polkowska-Pruszyńska, Agnieszka Gerkowicz, Paulina Szczepanik-Kułak, Dorota Krasowska
Systemic sclerosis (SSc) is a chronic, connective tissue disease with an autoimmune pattern characterized by inflammation, fibrosis and microcirculation changes leading to internal organs malfunctions. Recently, the presence of uncharacteristic gastrointestinal symptoms in the course of SSc has been underlined. The possible cause of such clinical presentation is the small intestinal bacterial overgrowth (SIBO). Nevertheless, these manifestations resulting from gastrointestinal tract hypomotility may occur in numerous disease entities...
October 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30370495/reconstructed-human-keloid-models-show-heterogeneity-within-keloid-scars
#4
Grace C Limandjaja, Leonarda J van den Broek, Taco Waaijman, Melanie Breetveld, Stan Monstrey, Rik J Scheper, Frank B Niessen, Susan Gibbs
Keloid scars are often described as having an actively growing peripheral margin with a regressing centre. The aim of this study was to examine the possible heterogeneity within keloids and the involvement of different regions within and around keloid scars in the pathogenesis, using an in vitro keloid scar model. In vitro skin models were constructed from keratinocytes and fibroblasts from normal skin and different regions within and around keloid scars: periphery, centre, and (adjacent) surrounding-normal-skin regions...
October 28, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30350131/benefits-of-a-membership-in-a-psoriasis-patient-organisation-a-quasi-experimental-longitudinal-study
#5
Anna Langenbruch, Marc A Radtke, Zinaida Foos, Matthias Augustin
BACKGROUND AND OBJECTIVES: Patient organisations play an important role in supporting patients with chronic diseases and allow information transfer beyond professional care structures. Until now, only few studies have investigated the benefits of a dermatological patient organisation. In this study, potential benefits of joining the German Psoriasis Association (Deutscher Psoriasis Bund e. V., DPB) were surveyed. METHODS: The quasi-experimental longitudinal design included four groups of individuals suffering from psoriasis: those (1) with DPB membership of 5 years, (2) with voluntary new membership, (3) with randomly awarded membership, and (4) without membership...
October 22, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30306262/topical-treatment-with-the-bacterium-derived-c-met-agonist-inlb-321-15-accelerates-healing-in-the-abrasion-wound-mouse-model
#6
Yaroslava M Chalenko, Elena V Sysolyatina, Konstantin A Sobyanin, Marina R Kapkaeva, Alexandra Lavrikova, Egor Kalinin, Olga N Scheglovitova, Svetlana A Ermolaeva
Studies of factors affecting wound-healing rates are encouraged by a critical need for new treatments to manage an increasing burden of non-healing wounds. The InlB protein produced by the Gram-positive bacterium Listeria monocytogenes is an agonist of the tyrosine kinase receptor c-Met and a functional analog of the hepatocyte growth factor (HGF), which is a mammalian ligand of c-Met. The recombinant InlB321 protein, which is the c-Met-binding InlB domain (amino acids 31-321), was cloned from the L. monocytogenes serovar 4b clinical strain VIMHA015 and serovar 1/2a strain EGDe (InlB321 /15 and InlB321 /EGDe, respectively)...
October 10, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30302557/inflammatory-reaction-clinical-efficacy-and-safety-of-bacterial-cellulose-wound-dressing-containing-silk-sericin-and-polyhexamethylene-biguanide-for-wound-treatment
#7
Supamas Napavichayanun, Sumate Ampawong, Tavornchai Harnsilpong, Apichai Angspatt, Pornanong Aramwit
Bacterial cellulose wound dressings containing silk sericin and PHMB (BCSP) were developed in our previous studies. It had good physical properties, efficacy, and safety. For further use as a medical material, this dressing was investigated for its efficacy and safety in split-thickness skin graft (STSG) donor-site wound treatment compared to Bactigras® (control). Moreover, the inflammatory responses to both dressings were also deeply investigated. For in vivo study, expressions of anti-inflammatory cytokines were intensely considered in the tissue interfacing area...
October 9, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30293125/visfatin-and-insulin-levels-and-cigarette-smoking-are-independent-risk-factors-for-hidradenitis-suppurativa-a-case-control-study
#8
Neslihan Akdogan, Nuran Alli, Pinar Incel Uysal, Canan Topcuoglu, Tuba Candar, Turan Turhan
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. HS has been associated with obesity, adipokine imbalance, dyslipidemia, pro-inflammation, and metabolic syndrome (MS). The aim of this study was to determine the association between HS, and serum visfatin levels (SVLs), small-dense low-density lipoprotein cholesterol (sdLDL-C), and ischemia-modified albumin (IMA), as well as the association between HS, and smoking, alcohol consumption, anthropometric measurements, blood pressures (BPs), fasting blood glucose (FBG) and lipids, inflammatory markers, homocysteine, uric acid (UA), serum insulin levels (SILs), insulin resistance (IR) and MS, so as to identify relevant risk factors for HS...
October 6, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30291412/effect-of-tofacitinib-on-the-expression-of-noggin-bmp-4-and-hair-growth-stimulation-in-mice
#9
J Meephansan, T Pongcharoensuk, J Thummakriengkrai, S Ponnikorn, W Yingmema, R Deenonpoe
Many hair loss disorders, including non-scaring alopecia, are caused by the arrest of hair follicles at the telogen phase, and the failure to enter the growth phase. Several studies report the efficacy of tofacitinib in promoting hair growth, by mechanisms not precisely known. The aim of this study was to identify other mechanisms by which tofacitinib, applied topically, promotes hair growth. The results showed that histopathological studies in mice treated topically with tofacitinib increased number of hair follicles, ratio of hair follicles in anagen phase, and length of hair infundibulum, and a reduced interfollicular epidermal thickness, compared to DMSO-treated mice...
October 5, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30244404/is-prolactin-a-negative-neuroendocrine-regulator-of-human-skin-re-epithelisation-after-wounding
#10
E A Langan, T Fink, R Paus
Chronic wounds remain a major unmet healthcare challenge, associated with substantial morbidity and economic costs. Therefore, novel treatment strategies and therapeutic approaches need to be urgently developed. Yet, despite the increasingly recognized importance of neurohormonal signaling in skin physiology, the neuroendocrine regulation of cutaneous wound healing has received surprisingly little attention. Human skin, and its appendages, locally express the pleiotropic neurohormone prolactin (PRL), which not only regulates lactation but also hair follicle cycling, angiogenesis, keratinocyte proliferation, and epithelial stem cell functions...
September 22, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30218143/melanoma-prone-families-new-evidence-of-distinctive-clinical-and-histological-features-of-melanomas-in-cdkn2a-mutation-carriers
#11
Laura Cristina Gironi, Enrico Colombo, Barbara Pasini, Roberto Giorgione, Pamela Farinelli, Francesca Zottarelli, Elia Esposto, Elisa Zavattaro, Elias Allara, Paola Ogliara, Marta Betti, Irma Dianzani, Paola Savoia
Germline mutations on the CDKN2A gene, the most important known genetic factors associated with cutaneous melanomas (CMs), predispose carriers to multiple primary CMs (MPMs) with higher frequency and younger onset compared to non-carriers. Most of the largest published studies concerning clinical and histological characteristics of CMs with CDKN2A mutation carriers did not specify if the described CMs are first or subsequent to the first, and they used sporadic CMs from non-genotyped patients as controls. We conducted a single-centre observational study to compare clinical and histological CM features of 32 unrelated carriers (MUT) of 5 germline CDKN2A mutations (one of which was never previously described) compared to 100 genotyped wild-type (WT) patients...
September 15, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30209581/decreased-expression-of-g-protein-coupled-receptors-gpr43-and-gpr109a-in-psoriatic-skin-can-be-restored-by-topical-application-of-sodium-butyrate
#12
Alicja Krejner, Anika Bruhs, Ulrich Mrowietz, Ulrike Wehkamp, Thomas Schwarz, Agatha Schwarz
The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of these receptors and their reaction to SB in psoriasis. Lesional and non-lesional biopsies of 6 psoriasis patients and of 4 controls were obtained and stained for GPR109a and GPR43...
September 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30209580/the-role-of-trka-in-the-promoting-wounding-healing-effect-of-cd271-on-epidermal-stem-cells
#13
Min Zhang, Yuehou Zhang, Jun Ding, Xiaohong Li, Chengyu Zang, Siyuan Yin, Jiaxu Ma, Yibing Wang, Yongqian Cao
CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exact role of TrkA combined with CD271 in eSCs during skin wound closure is still unclear. This study aimed to reveal the role of TrkA in the promoting wounding-healing effect of CD271 on eSCs. We obtained CD271-vo (over-expression of CD271) eSCs by lentiviral infection...
September 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167816/complex-segregation-analysis-of-facial-melasma-in-brazil-evidence-for-a-genetic-susceptibility-with-a-dominant-pattern-of-segregation
#14
Nicole França Holmo, Geovana Brotto Ramos, Heloisa Salomão, Renata Iani Werneck, Marcelo Távora Mira, Luciane Donida Bartoli Miot, Hélio Amante Miot
Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40-60%) suggests a genetic predisposition to the disease. This study explored, through complex segregation analysis (CSA), the inheritance model that best fit the family segregation pattern of facial melasma when accounting for the main epidemiological risk factors...
August 30, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30250964/systematic-review-of-mobile-phone-based-teledermatology
#15
REVIEW
Ashley K Clark, Suzana Bosanac, Baran Ho, Raja K Sivamani
Teledermatology is an expanding field within dermatology that has grown and become more clinically accepted by both patients and doctors. With approximately 260 million mobile phone users in the US and 4-6 billion worldwide with access to mobile phones, teledermatology serves as a potentially useful tool for diagnosis and management (Samkange-Zeeb and Blettner in Emerg Health Threats J, https://doi.org/10.3134/ehtj.09.005 , 2009). In this review, we provide a detailed overview of mobile phone technology and the accumulating evidence for its incorporation into dermatology...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30182275/age-related-and-seasonal-changes-in-covalently-bound-ceramide-content-in-forearm-stratum-corneum-of-japanese-subjects-determination-of-molecular-species-of-ceramides
#16
Anna Fujiwara, Masashi Morifuji, Masami Kitade, Keiko Kawahata, Tomoyuki Fukasawa, Taketo Yamaji, Hiroyuki Itoh, Makoto Kawashima
The stratum corneum (SC) consists of corneocytes surrounded by a neutral lipid-enriched intercellular matrix. Ceramides represent approximately 50% of intercellular lipids, and play important roles in retaining epidermal water. The SC also contains covalently bound ceramides, which are thought to play a crucial role in the formation of lamellar structures, and are involved in maintaining skin barrier function. A previous report showed that levels of free ceramides in human SC changed with the seasons and age, although whether the content of different species of covalently bound ceramides also underwent such temporal changes was unclear...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30171347/comprehensive-assessment-of-the-association-between-genes-on-jak-stat-pathway-ifih1-tyk2-il-10-and-systemic-lupus-erythematosus-a-meta-analysis
#17
Qiong Yin, Liang-Cai Wu, Lu Zheng, Ming-Yu Han, Li-Ya Hu, Pian-Pian Zhao, Wei-Yang Bai, Xiao-Wei Zhu, Jiang-Wei Xia, Xiao-Bo Wang, Xing-Wei Zhang, Hou-Feng Zheng
Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1 (9288 patients and 24,040 controls), TYK2 (4928 patients and 11,536 controls), IL-10 (3623 patients and 4907 controls) polymorphisms and systemic lupus erythematosus (SLE) in a comprehensive way. We found that IFIH1 rs1990760_T allele was associated with risk of SLE in overall population under three models (allelic: P = 2...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167814/achieving-international-consensus-on-the-assessment-of-psoriatic-arthritis-in-psoriasis-clinical-trials-an-international-dermatology-outcome-measures-ideom-initiative
#18
Lourdes Maria Perez-Chada, Jeffrey M Cohen, Alice Bendix Gottlieb, Kristina Callis Duffin, Amit Garg, John Latella, April Wang Armstrong, Alexis Ogdie, Joseph Frank Merola
Psoriatic arthritis (PsA) is rarely assessed in psoriasis randomized controlled trials (RCT); thus, the effect of psoriasis therapy on PsA is unknown. The International Dermatology Outcome Measures (IDEOM) has included "PsA Symptoms" as part of the core domains to be measured in psoriasis RCT. This study aimed to achieve consensus about screening for PsA and how to measure for "PsA Symptoms" in psoriasis RCT. At the IDEOM 2017 Annual Meeting, stakeholders voted on the role of PsA screening in psoriasis RCT...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30167813/a-comprehensive-in-vivo-study-of-caucasian-facial-skin-parameters-on-442-women
#19
Lenka Machková, Daniel Švadlák, Iva Dolečková
Generally, skin properties are highly specific for each individual depending on various factors such as genetic predisposition, age, gender, body region, health and lifestyle. In this study, we measured various skin parameters on forehead, temple and cheek of 442 Caucasian women between 23 and 63 years, and evaluated differences between these facial regions and also the relationship between skin parameters and age of the volunteers. We measured transepidermal water loss (TEWL), stratum corneum hydration, skin gloss, melanin level, individual typology angle (ITA), erythema, sebum level and elasticity (R7)...
November 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/30151656/the-investigation-of-the-relationships-of-demodex-density-with-inflammatory-response-and-oxidative-stress-in-rosacea
#20
Tuğba Falay Gur, Aslı Vefa Erdemir, Mehmet Salih Gurel, Abdurrahim Kocyigit, Eray Metin Guler, Duygu Erdil
The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis...
November 2018: Archives of Dermatological Research
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