journal
MENU ▼
Read by QxMD icon Read
search

Archives of Pharmacal Research

journal
https://www.readbyqxmd.com/read/30649699/therapeutic-implications-of-cancer-epithelial-mesenchymal-transition-emt
#1
REVIEW
Eunae Sandra Cho, Hee Eun Kang, Nam Hee Kim, Jong In Yook
The epithelial-mesenchymal transition (EMT) comprises an essential biological process involving cancer progression as well as initiation. While the EMT has been regarded as a phenotypic conversion from epithelial to mesenchymal cells, recent evidence indicates that it plays a critical role in stemness, metabolic reprogramming, immune evasion and therapeutic resistance of cancer cells. Interestingly, several transcriptional repressors including Snail (SNAI1), Slug (SNAI2) and the ZEB family constitute key players for EMT in cancer as well as in the developmental process...
January 16, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30637618/correction-to-dihydroxanthyletin-type-coumarins-from-angelica-decursiva-that-inhibits-the-formation-of-advanced-glycation-end-products-and-human-recombinant-aldose-reductase
#2
Md Yousof Ali, Hyun Ah Jung, Susoma Jannat, Jae Sue Choi
The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as: Conflict of interest The authors declare no conflict of interest.
January 12, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30637617/correction-to-development-of-a-column-switching-lc-ms-ms-method-of-tramadol-and-its-metabolites-in-hair-and-application-to-a-pharmacogenetic-study
#3
Hyerim Yu, Minje Choi, Jung-Hee Jang, Byoungduck Park, Young Ho Seo, Chul-Ho Jeong, Jung-Woo Bae, Sooyeun Lee
In the original version of the article titled "Development of a column-switching LC-MS/MS method of tramadol and its metabolites in hair and application to a pharmacogenetic study", published in 41(5):554-563 (https://doi.org/10.1007/s12272-018-1013-7), unfortunately an important statement was missing in the Clinical study section by the author.
January 12, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30632113/elucidation-for-modulation-of-death-receptor-dr-5-to-strengthen-apoptotic-signals-in-cancer-cells
#4
REVIEW
Kyoung-Jin Min, Seon Min Woo, Sk Abrar Shahriyar, Taeg Kyu Kwon
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis via death receptor (DR) 4 or DR5 preferentially in cancer cells, and not in normal cells with relatively high decoy receptor expression. However, multiple mechanisms in cancer cells induce resistance to DRs-mediated apoptosis. Therefore, understanding of molecular mechanisms for resistance to DRs-mediated apoptosis can find the strategy to increase sensitivity. Although multiple proteins are involved in resistance to DRs-mediated apoptosis, we focus on modulation of DR5 to overcome resistance...
January 10, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30632112/correction-to-development-of-a-linear-dual-column-hplc-ms-ms-method-and-clinical-genetic-evaluation-for-tramadol-and-its-phase-i-and-ii-metabolites-in-oral-fluid
#5
Hyerim Yu, Seongkuk Hong, Chul-Ho Jeong, Jung-Woo Bae, Sooyeun Lee
In the original version of the article titled "Development of a linear dual column HPLC-MS/MS method and clinical genetic evaluation for tramadol and its phase I and II metabolites in oral fluid", published in 41(3):288-298 ( https://doi.org/10.1007/s12272-017-0993-z ), unfortunately an important statement was missing in the Clinical study section by the author. The following statement: "The clinical study was approved by the Institutional Review Board of Keimyung University (Deagu, Republic of Korea, approval number: 40525-201509-BR-70-02) and Kyungpook National University Hospital (Daegu, Republic of Korea, approval number of clinical trial: 2016-08-005) and carried out at the Kyungpook National University Hospital Clinical Trial Center (Daegu, Republic of Korea)...
January 10, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30610617/post-translational-modification-of-the-death-receptor-complex-as-a-potential-therapeutic-target-in-cancer
#6
REVIEW
Kidong Kang, So-Ra Lee, Xuezhe Piao, Gang Min Hur
Programmed cell death is critical to the physiological function of multi-cellular organisms, controlling development, immunity, inflammation, and cancer progression. Death receptor (DR)-mediated regulation of a protease functions as a second messenger to initiate a death signal cascade to induce apoptosis or necroptosis. Recently, it has become clear that post-translational modifications (PTMs) of signaling components in the DR complex are highly complex, temporally controlled, and tightly regulated, and play an important role in cell death signaling...
January 4, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30610616/role-of-non-coding-rnas-in-liver-disease-progression-to-hepatocellular-carcinoma
#7
REVIEW
Mi Jeong Heo, Jessica Yun, Sang Geon Kim
Hepatocellular carcinoma (HCC) is a tumor with poor prognosis and frequently aggressive. The development of HCC is associated with fibrosis and cirrhosis, which mainly results from nonalcoholic fatty liver disease, excessive alcohol consumption, and viral infections. Non-coding RNAs (ncRNAs) are RNAs transcribed from the genome, but are not translated into proteins. Recently, ncRNAs emerged as key contributors to tumor development and progression because of their abilities to regulate various targets and modulate cell proliferation, differentiation, apoptosis, and development...
January 4, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30610615/lignans-from-saururus-chinensis-exhibit-anti-inflammatory-activity-by-influencing-the-nrf2-ho-1-activation-pathway
#8
Yeon Woo Jung, Bo Mi Lee, Manh Tuan Ha, Manh Hung Tran, Jeong Ah Kim, Suhyun Lee, Jeong Hyung Lee, Mi Hee Woo, Byung Sun Min
As part of our ongoing program to develop anti-inflammatory agents, an extract derived from Saururus chinensis collected in Korea was found to inhibit nitric oxide (NO) production in RAW264.7 cells. Bioassay-guided fractionation led to the isolation two new (1 and 2) and six known dineolignans (3-8). To the best of our knowledge, manassatin B1 (3) was isolated from S. chinensis for the first time. All structures were elucidated using extensive spectroscopic analysis. Of these compounds, 2 and 8 inhibited lipopolysaccharide (LPS)-induced production of NO and showed IC50 values of 5...
January 4, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30604201/tumor-endothelial-cells-as-a-potential-target-of-metronomic-chemotherapy
#9
REVIEW
Ji Yoon Kim, Young-Myeong Kim
Drug resistance and toxic side effects are major therapeutic hurdles affecting cancer patients receiving conventional chemotherapy based on the maximum tolerated dose. Metronomic chemotherapy (MCT), a new therapeutic approach developed to avoid these problems generally, consists of the continuous administration of low-dose cytotoxic agents without extended intervals. This therapy targets the tumor microenvironment, rather than exerting a direct effect on tumor cells. As a result, the MCT regimen functionally impairs tumor endothelial cells and circulating endothelial progenitor cells, leading to tumor dormancy via anti-angiogenesis...
January 2, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30600426/multifaceted-c-terminus-of-hsp70-interacting-protein-regulates-tumorigenesis-via-protein-quality-control
#10
REVIEW
Jinho Seo, Su Yeon Han, Daehyeon Seong, Hyun-Ji Han, Jaewhan Song
C-terminus of heat shock protein 70 (HSP70)-interacting protein (CHIP) is an E3 ligase involved in a variety of protein homeostasis events implicated in diverse signaling pathways. Its involvement in varied and even opposite signaling circuits might be due to its hallmark signature of associating with molecular chaperones, including HSP90 and HSP70. Together, these proteins may be pivotal in implementing protein quality control. A curious and puzzling aspect of the function of CHIP is its capability to induce protein degradation via the proteasome- or lysosome-dependent pathways...
January 1, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30599056/roles-of-folate-in-skeletal-muscle-cell-development-and-functions
#11
REVIEW
Seong Yeon Hwang, Bokyung Sung, Nam Deuk Kim
Folate is the generic term for both naturally occurring food folate and folic acid, the fully oxidized monoglutamate form of the vitamin that is used in dietary supplements and fortified foods. It is a water-soluble vitamin B9 and is important for health, growth, and development. As a precursor of various cofactors, folate is required for one-carbon donors in the synthesis of DNA bases and other essential biomolecules. A lack of dietary folate can lead to folate deficiency and can therefore result in several health problems, including macrocytic anemia, elevated plasma homocysteine, cardiovascular disease, birth defects, carcinogenesis, muscle weakness, and difficulty in walking...
January 1, 2019: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30569421/correction-to-polygonumnolides-a1-b3-minor-dianthrone-derivatives-from-the-roots-of-polygonum-multiflorum-thunb
#12
Jianbo Yang, Zheng Yan, Jin Ren, Zhong Dai, Shuangcheng Ma, Aiguo Wang, Yalun Su
The author would like to include conflict of interest statement and Grant Numbers (81773874 and 81703665) in the acknowledgement section of the online published article. The conflict of interest statement and acknowledgement section should read as.
December 19, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30542809/influence-of-cyp2d6-genetic-polymorphism-on-pharmacokinetics-of-active-moiety-of-tolterodine
#13
Ji-Yeong Byeon, Choong-Min Lee, Yea-Jin Lee, Young-Hoon Kim, Se-Hyung Kim, Eui Hyun Jung, Won Ki Chae, Yun Jeong Lee, Choon-Gon Jang, Seok-Yong Lee
Tolterodine is metabolized to an active 5-hydroxymethyl tolterodine (5-HMT) by CYP2D6. This study investigated the relationship between CYP2D6 genotypes and pharmacokinetics of tolterodine and its active metabolite in healthy Korean subjects. All volunteers were genotyped for CYP2D6 and divided into four different genotype groups (CYP2D6*wt/*wt [*wt = *1 or *2], CYP2D6*wt/*10, CYP2D6*10/*10, and CYP2D6*5/*10). Each subject received a single oral dose of tolterodine tartrate (2 mg) in single-dose phase of the study...
December 12, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30536027/therapeutic-targeting-of-lipid-synthesis-metabolism-for-selective-elimination-of-cancer-stem-cells
#14
REVIEW
Woo-Young Kim
Cancer stem cells (CSCs) are believed to have an essential role in tumor resistance and metastasis; however, no therapeutic strategy for the selective elimination of CSCs has been established. Recently, several studies have shown that the metabolic regulation for ATP synthesis and biological building block generation in CSCs are different from that in bulk cancer cells and rather similar to that in normal tissue stem cells. To take advantage of this difference for CSC elimination therapy, many studies have tested the effect of blocking these metabolism...
December 8, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30515725/proinvasive-extracellular-matrix-remodeling-for-tumor-progression
#15
REVIEW
Neha Kaushik, Seungmo Kim, Yongjoon Suh, Su-Jae Lee
Cancer is a systemic disease in which neoplastic cells interact with multiple types of non-neoplastic stromal cells as well as non-cellular components. The extracellular matrix (ECM) is a non-cellular component that is aberrantly regulated in many types of tumor microenvironments. Since the ECM generally maintains the tissue structure and provides mechanical forces in the tumor microenvironment, it has been simply assumed to act as a physical barrier for cancer metastasis and have a passive role in cancer progression...
December 4, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30506336/correction-to-anti-inflammatory-activity-of-compounds-from-the-rhizome-of-cnidium-officinale
#16
Huynh Nguyen Khanh Tran, Thao Quyen Cao, Jeong Ah Kim, Ui Joung Youn, Sanghee Kim, Mi Hee Woo, Byung Sun Min
The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.
November 30, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30478725/correction-to-varilactones-and-wortmannilactones-produced-by-penicillium-variabile-cultured-with-histone-deacetylase-inhibitor
#17
Xueqian He, Zhenzhen Zhang, Qian Che, Tianjiao Zhu, Qianqun Gu, Dehai Li
The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as.
November 26, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30470974/targeting-tyrosine-kinases-for-treatment-of-ocular-tumors
#18
REVIEW
Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim
Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Tyrosine kinases, which modulate signaling pathways regarding various cellular functions including proliferation, differentiation, and attachment, are one of the attractive targets for targeted therapies against uveal melanoma and retinoblastoma...
November 23, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30467625/correction-to-different-apoptotic-effects-of-saxifragifolin-c-in-human-breast-cancer-cells
#19
Kyung-Ho Kim, Ji-Yun Kim, Jong-Hwan Kwak, Byung Oh Kim, Suhkneung Pyo
The authors regret that incorrect western band of Bax (MDA-MB-231) in Fig. 6a (right panel) was mistakenly uploaded in the original publication. The correct Fig. 6a is shown below. This correction does not change the conclusions of this manuscript. The authors would like to apologize for any inconvenience caused.
November 22, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/30456742/correction-to-anti-inflammatory-activity-of-caffeic-acid-derivatives-isolated-from-the-roots-of-salvia-miltiorrhiza-bunge
#20
Hyun Gyu Choi, Phuong Thao Tran, Jeong-Hyung Lee, Byung Sun Min, Jeong Ah Kim
The author would like to include conflict of interest statement of the online published article. The correct conflict of interest statement should read as: Conflict of interest The authors declare no conflict of interest.
November 19, 2018: Archives of Pharmacal Research
journal
journal
27829
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"