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Archives of Pharmacal Research

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https://www.readbyqxmd.com/read/29243040/protective-effect-of-acacetin-on-sepsis-induced-acute-lung-injury-via-its-anti-inflammatory-and-antioxidative-activity
#1
Li-Chao Sun, Hong-Bo Zhang, Cheng-Dong Gu, Shi-Dong Guo, Gang Li, Rui Lian, Yao Yao, Guo-Qiang Zhang
Sepsis is a clinical syndrome with no effective protective or therapeutic treatments. Acacetin, a natural flavonoid compound, has anti-oxidative and anti-inflammatory effects which can potentially work to reduce sepsis. We investigated the potential protective effect of acacetin on sepsis-induced acute lung injury (ALI) ALI and dissect out the underlying mechanisms. Mice were divided into five groups: a sham group, a sepsis-induced ALI group, and three sepsis groups pre-treated with 20, 40, and 80 mg/kg body weight of acacetin...
December 14, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29243039/alkaloids-from-narcissus-poeticus-cv-pink-parasol-of-various-structural-types-and-their-biological-activity
#2
Marcela Šafratová, Anna Hošťálková, Daniela Hulcová, Kateřina Breiterová, Veronika Hrabcová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Jiří Kuneš, Jakub Chlebek, Daniel Jun, Martina Hrabinová, Lucie Nováková, Radim Havelek, Martina Seifrtová, Lubomír Opletal, Lucie Cahlíková
Fifteen Amaryllidaceae alkaloids (1-15) of various structural types were isolated by standard chromatographic methods from fresh bulbs of Narcissus poeticus cv. Pink Parasol. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic analyses, and by comparison with literature data. Narcipavline (5) and narcikachnine (6) are reported here for the first time. In their structure are combined two basic structural types of Amaryllidaceae alkaloids (galanthamine- and galanthindole-structural types), which represent a new structural type of these compounds...
December 14, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29230690/dihydroxanthyletin-type-coumarins-from-angelica-decursiva-that-inhibits-the-formation-of-advanced-glycation-end-products-and-human-recombinant-aldose-reductase
#3
Md Yousof Ali, Hyun Ah Jung, Susoma Jannat, Jae Sue Choi
The formation of advanced glycation end-products (AGE) and aldose reductase activity have been implicated in the development of diabetic complications. The present study was aimed to evaluate human recombinant aldose reductase (HRAR) and AGE inhibitory activity of seven natural dihydroxanthyletin-type coumarins, 4-hydroxy Pd-C-III (1), 4'-methoxy Pd-C-I (2), Pd-C-I (3), Pd-C-II (4), Pd-C-III (5), decursidin (6), and (+)-trans-decursidinol (7) from Angelica decursiva. Coumarins 1-7 showed potent HRAR and AGE inhibitory activities with ranges of IC50 values of 1...
December 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29230689/the-combination-of-curcumin-and-5-fluorouracil-in-cancer-therapy
#4
REVIEW
Yumeng Wei, Panjing Yang, Shousong Cao, Ling Zhao
5-Fluorouracil (5-FU) alone or in combination with other therapeutic drugs has been widely used for clinical treatment of various cancers. However, 5-FU-based chemotherapy has limited anticancer efficacy in clinic due to multidrug resistance and dose-limiting cytotoxicity. Some molecules and genes in cancer cells, such as nuclear factor kappa B, insulin-like growth factor-1 receptor, epidermal growth factor receptor, cyclooxygenase-2, signal transducer and activator of transcription 3, phosphatase and tensin homolog deleted on chromosome ten and Bcl-2 etc...
December 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29230688/therapeutic-effects-of-histone-deacetylase-inhibitors-on-kidney-disease
#5
REVIEW
Pusoon Chun
Increasing evidence has shown the involvement of histone deacetylases (HDACs) in the development and progression of various renal diseases, highlighting its inhibition as a promising therapeutic strategy to prevent kidney diseases. Accordingly, numerous studies have shown that HDAC inhibitors protect the kidneys from various diseases through their effects on multiple pathways, such as suppression of transforming growth factor-β signaling pathway and nuclear factor-κB signaling pathways, augmentation of apoptosis, and inhibition of angiogenesis...
December 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29214601/emerging-potential-of-stimulus-responsive-nanosized-anticancer-drug-delivery-systems-for-systemic-applications
#6
REVIEW
Hima Bindu Ruttala, Thiruganesh Ramasamy, Thiagarajan Madeshwaran, Tran Tuan Hiep, Umadevi Kandasamy, Kyung Taek Oh, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
The development of novel drug delivery systems based on well-defined polymer therapeutics has led to significant improvements in the treatment of multiple disorders. Advances in material chemistry, nanotechnology, and nanomedicine have revolutionized the practices of drug delivery. Stimulus-responsive material-based nanosized drug delivery systems have remarkable properties that allow them to circumvent biological barriers and achieve targeted intracellular drug delivery. Specifically, the development of novel nanocarrier-based therapeutics is the need of the hour in managing complex diseases...
December 6, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29214600/apoptosis-induction-by-alantolactone-in-breast-cancer-mda-mb-231-cells-through-reactive-oxygen-species-mediated-mitochondrion-dependent-pathway
#7
Li Cui, Weiquan Bu, Jie Song, Liang Feng, Tingting Xu, Dan Liu, Wenbo Ding, Jianhua Wang, Changyang Li, Binge Ma, Yi Luo, Ziyu Jiang, Chengcheng Wang, Juan Chen, Jian Hou, Hongmei Yan, Lei Yang, Xiaobin Jia
Alantolactone is a sesquiterpene lactone isolated from Inula helenium L. Although alantolactone possesses anti-inflammation and apoptosis-induction activities, the underlying mechanism of anti-cancer effect on human breast cancer cells remains largely unknown. In this study, we explored the possibility of alantolactone as an apoptosis-inducing cytotoxic agent using MDA-MB-231 cells as in vitro model. Alantolactone significantly induced its apoptosis, demonstrated by cell cycle analysis, annexin V-APC/7-AAD double staining and dUTP nick end labeling...
December 6, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29214599/protein-tyrosine-phosphatase-1b-inhibitors-from-natural-sources
#8
REVIEW
Bing Tian Zhao, Duc Hung Nguyen, Duc Dat Le, Jae Sue Choi, Byung Sun Min, Mi Hee Woo
Since PTP1B enzyme was discovered in 1988, it has captured the research community's attention. This landmark discovery has stimulated numerous research studies on a variety of human diseases, including cancer, inflammation, and diabetes. Tremendous progress has been made in finding PTP1B inhibitors and exploring PTP1B regulatory mechanisms. This review investigates for the natural PTP1B inhibitors, and focuses on the common characteristics of the discovered structures and structure-activity relationships. To facilitate understanding, all the natural compounds are here divided into five different classes (fatty acids, phenolics, terpenoids, steroids, and alkaloids), according to their skeletons...
December 6, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29196918/nafamostat-mesilate-negatively-regulates-the-metastasis-of-triple-negative-breast-cancer-cells
#9
Sunam Mander, Dong-Joo You, Sumi Park, Dong Hwi Kim, Hyo Jeong Yong, Dong-Sik Kim, Curie Ahn, Yun-Hee Kim, Jae Young Seong, Jong-Ik Hwang
Triple-negative breast cancer (TNBC) lacking of oestrogen receptor, progesterone receptor, and epidermal growth factor receptor type 2 is a highly malignant disease which results in a poor prognosis and rare treatment options. Despite the use of conventional chemotherapy for TNBC tumours, resistance and short duration responses limit the treatment efficacy. Therefore, a need exists to develop a new chemotherapy for TNBC. The aim of this study was to examine the anti-cancer effects of nafamostat mesilate (NM), a previously known serine protease inhibitor and highly safe drug on breast cancer cells...
December 1, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29196917/development-of-a-linear-dual-column-hplc-ms-ms-method-and-clinical-genetic-evaluation-for-tramadol-and-its-phase-i-and-ii-metabolites-in-oral-fluid
#10
Hyerim Yu, Seongkuk Hong, Chul-Ho Jeong, Jung-Woo Bae, Sooyeun Lee
Tramadol is a centrally acting synthetic opioid analgesic and has received special attention due to its abuse potential and unexpected responses induced by CYP2D6 polymorphism. Oral fluid is an advantageous biofluid for drug analysis due to non-invasive sampling and high correlation of drug concentrations with plasma. However, few studies have been performed on distribution of tramadol and its metabolites in oral fluid. In the present study, a linear dual column HPLC-MS/MS method was developed and fully validated for the simultaneous determination of tramadol and its phase I [O-desmethyltramadol (ODMT), N-desmethyltramadol (NDMT) and N,O-didesmethyltramadol (NODMT)] and II metabolites in oral fluid...
December 1, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29181640/impact-of-gut-microbiota-on-drug-metabolism-an-update-for-safe-and-effective-use-of-drugs
#11
REVIEW
Keumhan Noh, You Ra Kang, Mahesh Raj Nepal, Rajina Shakya, Mi Jeong Kang, Wonku Kang, Sangkyu Lee, Hye Gwang Jeong, Tae Cheon Jeong
The intestinal mucosa and liver have long been considered as the main sites of drug metabolism, and the contribution of gut microbiota to drug metabolism has been under-estimated. However, it is now generally accepted that the gut microbiota plays an important role in drug metabolism prior to drug absorption or during enterohepatic circulation via various microbial enzymatic reactions in the intestine. Moreover, some drugs are metabolized by gut microbiota to specific metabolite(s) that cannot be formed in the liver...
November 27, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29177586/phenolic-amides-from-tribulus-terrestris-and-their-inhibitory-effects-on-nitric-oxide-production-in-raw-264-7-cells
#12
Hyung Sik Kim, Jin Woo Lee, Hari Jang, Thi Phuong Linh Le, Jun Gu Kim, Moon Soon Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang
A new phenolic amide, named cis-terrestriamide (7), together with ten known compounds (1-6, 8-11), were isolated from the methanolic extract of the fruits of Tribulus terrestris. The structure of 7 was elucidated on the basis of extensive analyses of 1D and 2D nuclear magnetic resonance spectroscopic and high resolution mass spectrometry data. Compounds 1, 2, 5, 6, 8, 9, and 11 exhibited inhibitory effects on the lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 cells, with IC50 values of 18...
November 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29177585/the-role-of-exercise-induced-myokines-in-regulating-metabolism
#13
REVIEW
Joo Young Huh
Exercise has beneficial effects in ameliorating metabolic disorders, and a combined therapeutic regimen of regular exercise and pharmaceutical treatment is often recommended. Exercise biology is complex and it involves various metabolic and molecular changes that translate into changes in substrate utilization, enzyme activation, and alternatively, improvement in exercise performance. Besides the effect of exercise on muscle metabolism, it has recently been discovered that contracting muscle can induce secretion of molecules called myokines...
November 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29177584/sirtuin-6-a-possible-therapeutic-target-for-type-2-diabetes
#14
REVIEW
Eun Ju Bae
Sirtuin 6 (SIRT6), one of the seven members of mammalian sirtuin family, localizes in the nucleus and primarily regulates chromatin signaling and genomic integrity. Recent studies established the critical role of SIRT6 in the pathophysiology of metabolic disease, as well as its roles in longevity and cancer. These roles that were determined by genetic studies include promoting pancreatic insulin secretion, inhibiting hepatic gluconeogenesis and triglyceride synthesis, and suppressing adiposity, suggesting that SIRT6 activators are promising molecules for treating obesity and diabetes...
November 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29177868/%C3%AE-methyl-artoflavanocoumarin-from-juniperus-chinensis-exerts-anti-diabetic-effects-by-inhibiting-ptp1b-and-activating-the-pi3k-akt-signaling-pathway-in-insulin-resistant-hepg2-cells
#15
Hee Jin Jung, Su Hui Seong, Md Yousof Ali, Byung-Sun Min, Hyun Ah Jung, Jae Sue Choi
Diabetes mellitus is one of the greatest global health issues and much research effort continues to be directed toward identifying novel therapeutic agents. Insulin resistance is a challenging integrally related topic and molecules capable of overcoming it are of considerable therapeutic interest in the context of type 2 diabetes mellitus (T2DM). Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling transduction and is regarded a novel therapeutic target in T2DM. Here, we investigated the inhibitory effect of α-methyl artoflavanocoumarin (MAFC), a natural flavanocoumarin isolated from Juniperus chinensis, on PTP1B in insulin-resistant HepG2 cells...
November 24, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29170993/limonoids-from-the-roots-of-trichilia-sinensis-and-their-cytotoxicities
#16
Shou-Bai Liu, Wen-Li Mei, Hui-Qin Chen, Jun Wang, Zhu-Nian Wang, Hao-Fu Dai
Six new compounds (1-4, 8, 10), along with six known limonoids (5-7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including (1)H NMR, (13)C NMR, DEPT, HSQC, HMBC, (1)H-(1)H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines...
November 23, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29159582/development-of-taladegib-as-a-sonic-hedgehog-signaling-pathway-inhibitor
#17
Guanghai Jin, Aneesh Sivaraman, Kyeong Lee
No abstract text is available yet for this article.
November 20, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29159581/inhibition-of-salivary-secretion-by-tolterodine-transdermal-patch
#18
Ji-Yeong Byeon, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Chang-Ik Choi, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Tolterodine, a nonselective muscarinic antagonist available only as immediate release (IR) or extended release (ER) oral formulations, is used for the treatment of overactive bladder (OAB). This study aimed to compare the efficacy and extent of dry mouth adverse effects of tolterodine transdermal patch to the oral formulation. The two formulations have been examined through the muscarinic receptor binding tests conducted in bladder and salivary gland tissues and the salivary secretion tests conducted in rats...
November 20, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29147873/comparison-of-the-adjuvanticity-of-two-adjuvant-formulations-containing-de-o-acylated-lipooligosaccharide-on-japanese-encephalitis-vaccine-in-mice
#19
Ara Ko, Seo Ri Wui, Ji In Ryu, Hien Thi Thu Do, Yeon Jeong Lee, Soo Jeong Lim, Inmoo Rhee, Dae Im Jung, Jin-Ah Park, Jung-Ah Choi, Man Ki Song, Na Gyong Lee
Adjuvants are essential vaccine components used to enhance, accelerate, and/or prolong adaptive immunity against specific vaccine antigens. In this study, we compared the adjuvanticity of two adjuvant formulations containing de-O-acylated lipooligosaccharide (dLOS), a toll-like receptor 4 agonist, on the Japanese encephalitis (JE) vaccine in mice. Mice were immunized once or twice at a two-week interval with inactivated JE vaccine in the absence or presence of adjuvant. We found that both the alum- and the liposome-based formulation induced significantly faster and higher serum IgG antibody responses as compared with the non-adjuvanted vaccine after either one or two immunizations...
November 17, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29128914/simultaneous-determination-of-tolterodine-and-its-two-metabolites-5-hydroxymethyltolterodine-and-n-dealkyltolterodine-in-human-plasma-using-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#20
Young-Hoon Kim, Ji-Yeong Byeon, Se-Hyung Kim, Choong-Min Lee, Eui Hyun Jung, Won Ki Chae, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Tolterodine is a nonselective muscarinic antagonist that is indicated for the overactive urinary bladder and other urinary difficulties. We developed and validated a simple, rapid and sensitive high-performance liquid chromatography analytical method utilizing tandem mass spectrometry (LC-MS/MS) for the quantitation of tolterodine and its major metabolites, 5-hydroxymethyltolterodine (5-HMT) and N-dealkyltolterodine (NDT), in human plasma. After liquid-liquid extraction with methyl t-butyl ether, chromatographic separation of the three analytes was achieved using a reversed-phase Luna Phenyl-hexyl column (100 × 2...
November 11, 2017: Archives of Pharmacal Research
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