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Psychiatry Research

Zongchang Li, Ying He, Xiaoqian Ma, Xiaogang Chen
A large body of evidence indicates major depressive disorder (MDD) associated with biological aging acceleration. In this study, we aim to assess epigenetic aging in different prefrontal sub-regions and cell types from postmortem tissues in MDD by using two public methylation datasets (subjects are 40 and 58 respectively). Results showed that brain epigenetic age has a strong correlation with chronological age in both datasets. However, there are no significant differences in epigenetic aging acceleration between MDD and controls in all prefrontal sub-regions and cell types...
September 6, 2018: Psychiatry Research
Feng-Na Yu, Nai-Qi Hu, Xun-Lan Huang, Yun-Xia Shi, Huan-Zong Zhao, Hai-Ying Cheng
The aim of this study was to assess the association of empirically derived dietary patterns with cognitive function among a middle-aged and elder Chinese population. This study comprised 1676 Chinese adults ≥45 years of age, who participated in a Health Survey and completed semi-quantitative food frequency questionnaire (FFQ) and cognitive screening test in the city of Linyi.We performed factor analysis using the principal component analysis method to identify the major dietary patterns. Binary logistic regression models were used to estimate odds ratio(OR) and 95% confidence interval(CI) for cognitive impairment according to quartiles of each dietary pattern score...
September 5, 2018: Psychiatry Research
César González-Blanch, Fernando Hernández-de-Hita, Roger Muñoz-Navarro, Paloma Ruíz-Rodríguez, Leonardo Adrián Medrano, Juan Antonio Moriana, Antonio Cano-Vindel
This study explores the associations between different disability domains and the most prevalent symptoms of mental disorders in primary care patients (i.e. depression, anxiety, and somatization). A total of 1241 participants from 28 primary care centres completed self-report measures of depression, anxiety, and somatization. This same sample also completed the Sheehan Disability Scale (SDS) to assess functional impairment in work, social life, and family life domains. Associations between the symptoms and each disability domain were examined using hierarchical regression analyses...
September 5, 2018: Psychiatry Research
Pablo Figueroa Lanteri, Alexander Leguia, Núria Garcia Doladé, Gloria Cereza García, Albert Figueras
The widespread use of dopaminergic agents for the treatment of Parkinson's disease has revealed the presence of gambling disorder (GD) as an uncommon, but serious, adverse reaction to these agents. We describe the main characteristics of drug-induced GD reports received by the Spanish Pharmacovigilance System during the period from 1983 to 2016. Fifteen reports of GD have been identified. Dopaminergic agonists, especially pramipexole, are the main drugs involved in inducing GD. Physicians prescribing these drugs should warn patients and families about this disorder...
September 5, 2018: Psychiatry Research
Deanna L Kelly, Xin Li, Catherine Kilday, Stephanie Feldman, Sarah Clark, Fang Liu, Robert W Buchanan, Leonardo H Tonelli
Immunological abnormalities are increasingly reported in people with schizophrenia, but no clear functional biomarkers associated with genetic correlates of the disease have been found. Regulatory T cells (Tregs) are key immunoregulatory cells involved in the control of inflammatory processes and their functions are directly related to the human leucocyte antigen (HLA) gene, which has been implicated in schizophrenia genetic studies. However, there is a lack of studies reporting Treg status in people with schizophrenia...
September 5, 2018: Psychiatry Research
Lorena De la Fuente-Tomás, Pilar Sierra, Mónica Sanchez-Autet, Ana García-Blanco, Gemma Safont, Belén Arranz, Maria P García-Portilla
There is scarce knowledge about the impact of sleep disturbances on functioning and quality of life (QoL). This study aims to investigate the links between sleep satisfaction and duration, and functioning and QoL in euthymic BD patients. We made a secondary analysis of a cross-sectional, naturalistic, multicenter study. INCLUSION CRITERIA: DSM-IV BD diagnosis; age > 17 years; written informed consent. SAMPLE: 119 Spanish euthymic BD outpatients. Hierarchical multiple regressions were performed controlling for confounding factors...
September 1, 2018: Psychiatry Research
Suzanne Brugman, Jill Lobbestael, Alexander T Sack, Maaike J Cima, Teresa Schuhmann, Franziska Emmerling, Arnoud Arntz
This study aimed at examining cognitive predictors of reactive and proactive aggression in a forensic-psychiatric (n = 80) and a non-clinical sample (n = 98; Brugman et al., 2015). Three different cognitive predictors were incorporated: (1) attentional bias towards aggressive stimuli (measured with Emotional Stroop task) and towards angry faces (measured with a visual search task); (2) interpretation biases (measured with Aggressive Interpretative Bias Task (AIBT) and a vignette task), and (3) implicit self-aggression association (measured with a Single-Target Implicit Association Task)...
August 31, 2018: Psychiatry Research
Aja Louise Murray, Tom Booth, Ingrid Obsuth, Jan Zirk-Sadowski, Manuel Eisner, Denis Ribeaud
Both anxiety and aggression commonly co-occur with ADHD symptoms. Two competing hypotheses describing the role of anxiety in aggression associated with ADHD symptoms have previously been advanced. The exacerbation hypothesis proposes that the presence of anxiety increases the risk of aggression in the context of ADHD symptoms. The attenuation hypothesis proposes that the presence of anxiety protects against aggression in the context of ADHD symptoms. We tested these hypotheses using moderated cross-lagged panel models in the Zurich project on social development from childhood to adulthood (z-proso) sample using both self-report (3 waves) and informant-report (8 waves) data spanning ages 7-17...
August 31, 2018: Psychiatry Research
Qin Zhou, Tianyu Wang, Kisalaya Basu
The association between body size and mental health has been the focus of many studies. Results, however, varies between studies. This study aimed to investigate the association between BMI and depressive symptoms among Chinese adults. We also further explored childhood starvation as a potential mediator of this association. The China Health and Retirement Longitudinal Study data, a representative national survey of adults age 45 and older was used in this study. Results showed that the prevalence of overweight and obesity were 28...
August 31, 2018: Psychiatry Research
Felice Iasevoli, Camilla Avagliano, Benedetta Altavilla, Annarita Barone, Mariateresa Ciccarelli, Luigi D'Ambrosio, Danilo Notar Francesco, Eugenio Razzino, Michele Fornaro, Andrea de Bartolomeis
Here, we used Receiver Operating Characteristic (ROC) curve analysis to determine whether clinical factors may aid predicting the categorization of schizophrenia patients as Treatment Resistant (TRS) or antipsychotic responsive schizophrenia (ARS). Patients with an established condition of TRS or ARS were assessed for: clinical presentation and course; neurological soft signs (NES); psychopathology by PANSS; cognitive performances; quality of life scale (QLS); functional capacity; social functioning (PSP and SLOF scales)...
August 31, 2018: Psychiatry Research
Jiahui Ma, Bin Wang, Xi Gao, Hao Wu, Dongfang Wang, Nan Li, Jiping Tan, Jingyu Wang, Lailai Yan
Toxic metals are ubiquitous environmental pollutants, and their potential risks associated with the development of schizophrenia remain a subject of debate. In this study, we investigated the associations between six typical toxic metals (mercury, lead, chromium, silver, antimony, and uranium) in serum with the risk of schizophrenia using a case-control study design. In total, 109 patients with schizophrenia (cases) and 106 normal subjects (controls) from Shandong Province, China were recruited. Fasting blood samples were collected from all participants, as well as serum samples from the cases before and after medical treatment...
August 30, 2018: Psychiatry Research
Xiangfei Meng, Marie-Josee Fleury, Jean-Marie Bamvita, Guy Grenier, Jean Caron
There is a paucity of research on determinants associated with changes in perceived met needs for care over time. This study used a longitudinal cohort to explore changes in percentages of perceived met needs over time and to identify its related determinants. Data analyzed was from a longitudinal community-based survey. A total of 150 participants received at least one type of help both at baseline and a 2-year follow-up. Multivariate analyses were used. Perceived met needs of the study sample slightly increased over time...
August 29, 2018: Psychiatry Research
Michael J Zvolensky, Lorra Garey, Thomas A Fergus, Matthew W Gallagher, Andres G Viana, Justin M Shepherd, Nubia A Mayorga, Lance P Kelley, Jackson O Griggs, Norman B Schmidt
Anxiety sensitivity, defined as the fear of anxiety and arousal-related sensations, has been among the most influential cognitive-based transdiagnostic risk and maintenance factors in the study and treatment of emotional and related disorders. The currently available anxiety sensitivity measures are limited by their length. Specifically, the length of these instruments discourages the adoption of routine anxiety sensitivity assessment in clinical or medical settings (e.g., primary care). The goals of this study were to develop and assess the validity and reliability of a short version of the Anxiety Sensitivity Index-3 (ASI-3; Taylor et al...
August 29, 2018: Psychiatry Research
Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Zhuo-Wei Gao, Dong Shen
Post-traumatic stress disorder (PTSD) is a serious psychiatric disorder. Estazolam has been shown to produce anxiolytic-, hypnotic-, amnestic-, and sedative-like effects. However, few studies are concerned about its anti-PTSD-like effects. The anti-PTSD-like effects of estazolam were evaluated by single prolonged stress animal model. After exposure to single prolonged stress, rats (Sprague-Dawley, male, 8 weeks) were administered by estazolam (0.5, 1 and 2 mg/kg, i.p.) from day 2 to 13 once daily. The behavioral assessments were performed during treatment with drugs...
August 29, 2018: Psychiatry Research
Bilge Evren, Cuneyt Evren, Ercan Dalbudak, Merve Topcu, Nilay Kutlu
The aim of the present study was to evaluate relationship of Internet addiction (IA) symptom severity with probable attention deficit/hyperactivity disorder (ADHD) and difficulties in emotion regulation, while controlling the effects of depression, anxiety and neuroticism. The study was conducted with online survey among 1010 volunteered participants of university students and/or amateur or professional gamers. Scale scores were higher among the group with high probability of ADHD (n = 190, 18.8%). In linear regression analysis, both Inattentiveness and hyperactivity/impulsivity dimensions of ADHD were related with the severity of IA symptoms, together with depression and non-accept dimension of the Difficulties in Emotion Regulation Scale (DERS)...
August 29, 2018: Psychiatry Research
Morgan N McCredie, John E Kurtz, Leanne Valentine
The Personality Assessment Inventory (PAI; Morey, 1991) contains scales that were designed to make predictions about how an individual might respond to treatment, thereby allowing clinicians to attune treatment plans to a client's specific needs. The present study utilized two features of the PAI as predictors of treatment process and outcome in a sample of 47 outpatient veterans: the Treatment Rejection (RXR) scale and the Treatment Process Index (TPI). Data were collected for three treatment process and outcome measures: treatment utilization (ratio of appointments attended to appointments scheduled), therapist-rated therapeutic alliance, and symptom change over time...
August 29, 2018: Psychiatry Research
Sarojini M Sengupta, Nellie Fotopoulos, Gabriel A Devenyi, Marie-Ève Fortier, Marina Ter-Stepanian, Saba Sagliker, Sherif Karama, M Mallar Chakravarty, Aurelie Labbe, Natalie Grizenko, Ridha Joober
Several epidemiological and genetic studies have provided evidence of an overlap between neurodevelopmental disorders. However, the details of the etiological pathways remain to be elucidated. In this study, we garnered the findings of previous GWAS, conducted with schizophrenia and bipolar disorder. We conducted an exploratory study to examine the association between these SNPs and quantitative clinical/ behavioural/ cognitive/ structural brain parameters, as well as response to treatment with a fixed dose of methylphenidate, in a relatively large sample of children with ADHD...
August 28, 2018: Psychiatry Research
Yanjing Xu, Chihhuan Wang, Mengmeng Shi
Adolescent suicide has become a serious public health problem in China. Since suicide attempts are considered the strongest predictor of suicide completion, it is valuable to identify adolescents with a high suicide attempt risk. This study aimed to develop a decision tree model for the interactive prediction of high suicide attempt risk in Chinese adolescents. A classification tree analysis was conducted in a sample of senior high school students (N = 6,686) based on the CRUISE program. The results indicated that depression, anxiety, social support, gender, self-esteem, family cohesion and adaptability were significant predictors of high suicide attempt risk, and interactions among these predictors constructed a hierarchical decision tree model...
August 28, 2018: Psychiatry Research
Chloe A Hamza, Teena Willoughby
Nonsuicidal self-injury (NSSI; e.g., self-cutting without lethal intent) is a widespread mental health concern among emerging adults in university. Although accumulating evidence suggests that NSSI is primarily an emotion coping behaviour, little is known about variability in emotional response to pain among individuals who self-injure. Recent theory on NSSI suggests that individuals who engage in NSSI to self-punish may experience additional affective gains in response to pain compared to individuals without self-punishment motivations for NSSI and individuals who do not self-injure...
August 28, 2018: Psychiatry Research
Youssef Kouidrat, Ali Amad, Brendon Stubbs, Rufin Louhou, Nathalie Renard, Momar Diouf, Jean-Daniel Lalau, Gwenole Loas
Whilst people with schizophrenia have high levels of obesity and metabolic disease, our understanding of their eating behaviors is still limited. Our aim was to evaluate the relationships between eating behavior and clinical data in schizophrenia. A cross-sectional study including 66 schizophrenia outpatients compared to 81 healthy controls was undertaken. Eating behavior was assessed using the shortened 21-item version of the Three-Factor Eating Questionnaire (TFEQ-R21). The patients had a mean of 44 ± 11 years; a mean BMI of 30...
August 28, 2018: Psychiatry Research
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