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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/28816744/eruptive-keratoacanthoma-like-discoid-lupus-erythematosus
#1
Corey Georgesen, Cynthia Magro
Hypertrophic discoid lupus erythematosus can resemble keratoacanthoma histomorphologically. We describe a unique case of eruptive keratoacanthomatous scaly papules in a 56-year-old woman with discoid lupus erythematosus. We review the literature and conclude by discussing important histologic features and useful immunostains to consider when attempting to discern the underlying identity and pathogenicity of such lesions.
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816743/elastic-staining-in-differentiating-between-follicular-streamers-and-follicular-scars-in-horizontal-scalp-biopsy-sections
#2
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. METHODS: Sixty-four cicatricial alopecias (25 lichen planopilaris, 29 central centrifugal cicatricial alopecias, and 10 discoid lupus erythematosus) and 53 noncicatricial alopecias (34 androgenic alopecia, 8 telogen effluvium, and 11 alopecia areata) were identified, and EVG staining was performed on horizontal sections...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816742/congenital-lesion-on-the-hand-of-a-child
#3
Eduardo Varas-Meis, Alicia Perez-Bustillo, Sonsoles Vicente-Delgado, Maria Asunción Gonzalez-Morán, Manuel Ángel Rodríguez Prieto
No abstract text is available yet for this article.
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816741/reflectance-confocal-microscopy-criteria-of-pigmented-squamous-cell-carcinoma-in-situ
#4
Neda Shahriari, Jane M Grant-Kels, Harold S Rabinovitz, Margaret Oliviero, Alon Scope
Pigmented squamous cell carcinoma in situ (pSCCis) is difficult to diagnose based on clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) allows noninvasive differentiation between malignant and benign pigmented skin lesions. We determined the frequency of key RCM features of pSCCis and correlated the RCM criteria with the corresponding dermoscopic and histopathologic criteria. The study included 28 lesions with biopsy-proven diagnosis of pSCCis derived from 28 patients. Clinical, dermoscopic, and RCM images of these lesions were retrospectively analyzed by 3 independent observers...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816740/the-value-of-direct-immunofluorescence-on-proteinase-digested-formalin-fixed-paraffin-embedded-skin-biopsies
#5
Aida Valencia-Guerrero, April Deng, Karen Dresser, Gail Bouliane, Kristine M Cornejo
Direct immunofluorescence (DIF) on frozen tissue (DIF-F) is the method of choice for the identification of immune deposits present in skin and other tissues. DIF can also be performed on formalin-fixed paraffin-embedded tissue (DIF-P) after antigen retrieval with proteases and has proven to be of value in renal pathology. However, its utility in skin biopsies has not been fully examined. In this study, we performed DIF-P on 60 skin biopsies that comprised of bullous pemphigoid (n = 18), pemphigoid gestationis (n = 1), pemphigus (n = 7), linear IgA disease (n = 7), vasculitis (n = 20), lupus erythematosus (n = 3), and dermatitis herpetiformis (n = 4) cases...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816739/nicolau-syndrome-embolia-cutis-medicamentosa-a-rare-and-poorly-recognized-iatrogenic-cause-of-cutaneous-thrombotic-vasculopathy
#6
Dominic Tabor, Chandra G Bertram, Andrew J K Williams, Marie E Mathers, Asok Biswas
Nicolau syndrome is a rare form of iatrogenic cutaneous necrosis which affects injection sites. Although classically associated with intramuscular injections, it may develop after subcutaneous or other routes of parenteral drug administration. Clinically, it manifests as necrotic ulcers that often develop in a background of erythematous and livedoid reticular patches. The histopathologic characteristics of Nicolau syndrome are poorly documented in the dermatopathology literature and features only rarely as one of the obscure causes of cutaneous thrombotic vasculopathy...
August 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816738/progressive-painful-erosions-of-the-face-neck-and-lips
#7
Caitlin May, Michi Shinohara
No abstract text is available yet for this article.
August 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816737/necrotizing-infundibular-crystalline-folliculitis-an-unusual-clinical-presentation-and-demonstration-of-the-presence-of-calcium-palmitate
#8
Aurélie Beaufrère, Valérie Garcia, Vincent Frochot, Thierry Molina, Michel Daudon, Sylvie Fraitag
Necrotizing infundibular crystalline folliculitis (NICF) is a rare disorder, which was described for the first time by Lucke et al in 1999. NICF is characterized by multiple folliculocentric papules with a predilection for occurring in seborrheic areas in adults and corresponding dilated follicular ostia containing crystalline material. The precise pathogenesis and nature of this crystalline material are currently unknown. Here, we report an unusual case of NICF presented as an uncommon generalized skin rash in an adolescent...
August 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28796694/myoepithelioma-of-soft-tissue-with-both-squamous-and-adipocytic-metaplasia
#9
Ashley Elsensohn, Joshua H Mo, Tyler J Maly, Patrick K Lee, Sebastien de Feraudy
Soft tissue, or cutaneous, myoepitheliomas are rare tumors arising solely from a myoepithelial origin. These neoplasms are typically associated with uncertain differentiation and can contain cellular morphologies that include spindle, plasmacytoid, epithelioid, or clear cell forms. Soft tissue myoepitheliomas are commonly found on the lower limbs and in the pelvic girdle but can occur throughout the body. A small minority display heterogenous differentiation, typically osseous or cartilaginous in nature. Squamous and adipocytic cell types are much rarer...
August 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28796693/enhanced-worldwide-dermatology-pathology-interaction-via-facebook-twitter-and-other-social-media-platforms
#10
Bhushan Madke, Jerad M Gardner
The practice of dermatopathology requires close interaction between dermatologists and dermatopathologists. Yet, in many areas of the developing world, dermatologists lack easy access to pathologists with expertise in skin disease. Twitter, Facebook, and other social media provide free powerful tools that enhance interaction between dermatology and pathology regardless of geographic barriers. Although there are some limitations, the immense potential benefits that social media unlocks for patient care, education, research, and networking cannot be overstated...
August 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28796692/reticulated-purpura-in-the-abdomen-of-a-severely-ill-patient
#11
Caio Formiga, Karla Pacheco, Thiago Jeunon
No abstract text is available yet for this article.
August 3, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28763335/validation-of-digital-pathology-for-primary-histopathological-diagnosis-of-routine-inflammatory-dermatopathology-cases
#12
Jonathan J Lee, Jaroslaw Jedrych, Liron Pantanowitz, Jonhan Ho
BACKGROUND: Digital pathology (DP) systems have been validated for routine, histopathological diagnosis by several investigators. The diagnostic matter in previous studies is composed mostly of neoplasms. However, in dermatopathology, inflammatory diseases constitute a greater proportion of cases and have been under-represented in this literature. Herein, we report the results of a prospective, DP side-by-side validation study comparing the histologic assessment of routine, clinical inflammatory dermatopathology cases by whole slide imaging (WSI) and traditional light microscopy (LM)...
July 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28763334/pseudomelanomas-following-stevens-johnson-syndrome
#13
Nima Mesbah Ardakani, Shevya M Tiwari, Benjamin A Wood
In this report, we present a novel case of pseudomelanoma, similar to that seen in a recurrent/traumatized nevus, in pre-existing nevi in a 36-year-old man a few months after recovering from an episode of severe Stevens-Johnson syndrome. The mechanism responsible for the atypical transformation of these nevi is likely the release of cytokines and growth factors in the microenvironment during the repair/regeneration process. It is important to be aware of this phenomenon, and specific inquiry about potential recent blistering skin disorder in addition to the other causes of trauma should be made when dealing with cases of pseudomelanoma to avoid misdiagnosis...
July 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28763338/bullous-erythema-nodosum-leprosum-as-the-first-manifestation-of-multibacillary-leprosy-a-rare-phenomenon
#14
Neha Bakshi, Seema Rao, Rohit Batra
Erythema nodosum leprosum (ENL) may uncommonly present before treatment in patients with multibacillary leprosy. Atypical manifestations are known in ENL and may be clinically misleading. Such wide variations in the clinical presentation of leprosy in reaction make histopathology an important tool for supporting clinical diagnosis. We report bullous ENL presenting as the first manifestation of leprosy in a 30-year-old Indian man diagnosed using histopathology.
July 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28746056/volar-papulonodules-in-a-patient-with-seronegative-rheumatoid-arthritis
#15
Justin P Bandino, Dirk M Elston
No abstract text is available yet for this article.
July 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28746055/a-verrucous-plaque-on-the-abdomen
#16
Sara E Chapman, Justin P Bandino
No abstract text is available yet for this article.
July 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28746054/nutritional-deficiency-related-oral-and-cutaneous-lesions-in-an-obese-patient
#17
Lilly Esquivel-Pedraza, Silvia Méndez-Flores, Alba Cicero-Casarrubias, Marcela Saeb-Lima, Judith Domínguez-Cherit, Laura Fernández-Cuevas
The cutaneous and oral lesions related to nutritional deficiencies are scarcely reported. Micronutrient deficiencies may significantly affect mouth mucosa and skin, causing great morbidity. We report an extraordinary case with detailed clinical and microscopic findings affecting the oral cavity and skin. Physicians must be familiar with these manifestations to suspect the diagnosis.
July 17, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719440/onychomatricoma-in-a-patient-with-extensive-vitiligo
#18
Emily L Behrens, Maliha Khan, Ashley Sturgeon, Michelle Tarbox
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719439/papulonodular-eruption-on-the-hands-in-a-patient-with-arthritis
#19
Trevor Hansen, Julie Dhossche, Stephanie Mengden Koon, Nicole Fett
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719438/comparative-analysis-of-chilblain-lupus-erythematosus-and-idiopathic-perniosis-histopathologic-features-and-immunohistochemistry-for-cd123-and-cd30
#20
Michael L Wang, May P Chan
Distinction of chilblain lupus erythematosus (CLE) from idiopathic perniosis (IP) could predict an underlying connective tissue disease; however, histopathologic discrimination of the two is difficult. Increased CD123 plasmacytoid dendritic cells and CD30 lymphocytes have been demonstrated in various forms of cutaneous lupus erythematosus and IP, respectively. To our knowledge, CD123 and CD30 have not been examined in CLE. Our objective was to identify helpful histopathologic and immunohistochemical features in distinguishing CLE and IP...
July 14, 2017: American Journal of Dermatopathology
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