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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/29210716/relationship-between-pityriasis-lichenoides-and-mycosis-fungoides-a-clinicopathological-immunohistochemical-and-molecular-study
#1
Hiba Zaaroura, Dvora Sahar, Tova Bick, Reuven Bergman
BACKGROUND: Several cases of pityriasis lichenoides (PL) have been reported to evolve into mycosis fungoides (MF). OBJECTIVE: To elucidate clues to this progression. METHODS: Fifty-eight patients with PL between 2000 and 2013 (follow-up: 3-16 years, average: 8.3). RESULTS: A total of 3 (5.2%) of the 58 patients with PL developed MF after 3-11 years of prolonged clinical course. Papules and small plaques characterized PLs, and patches and larger plaques subsequent MFs...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#2
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29210714/intertriginous-and-seborrheic-dermatitis-like-lesions-in-an-endocrine-patient
#3
Caterina Ferreli, Federica Guicciardi, Luca Pilloni, Paola Elisa Meloni, Stefano Mariotti, Franco Rongioletti
No abstract text is available yet for this article.
November 21, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29210713/intradermal-proliferative-fasciitis-occurring-with-chondrodermatitis-nodularis-helicis
#4
Ashley Elsensohn, Sasha Getty, Jessica Shiu, Sébastien de Feraudy
Nodular fasciitis is a benign myofibroblastic tumor. Its uncommon variant, proliferative fasciitis (PF), can present in an even less common intradermal form. We report a case of intradermal PF of the ear in a 45-year-old man who presented with recurrent episodes of pain and swelling of the lesion. Histologic examination showed a dermal, nodular proliferation of ganglion-like basophilic fibroblasts with prominent nuclei and nucleoli, admixed with foamy histiocytes and areas of spindle cells arranged in intersecting fascicles in a fibromyxoid background...
November 21, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135510/mycosis-fungoides-manifesting-as-giant-cell-lichenoid-dermatitis
#5
Irena E Belousova, Vladislav R Khairutdinov, Anna Bessalova, Dmitry V Kazakov
Mycosis fungoides (MF) is the most common form of primary cutaneous lymphoma with a broad clinicopathological spectrum. Unusual histopathologic patterns of MF include lichenoid, interstitial, folliculotropic, spongiotic, granulomatous, and many others. Several cases of unusual lichenoid reaction characterized by a mixed lichenoid inflammatory infiltrate with prominent infiltration of the papillary dermis and epidermis by multinucleated giant cells were described under the name of "giant cell lichenoid dermatitis," most of them were considered to represent a drug eruption...
November 10, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29053495/painful-skin-nodule-on-the-finger-of-a-59-year-old
#6
Nicholas J Olson, Gregory D Seidel, Konstantinos Linos
No abstract text is available yet for this article.
November 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29176482/widespread-erythematous-and-bullous-plaques-associated-with-nasolabial-fold-ulceration
#7
Laura Mesa-Álvarez, Gonzalo Peón Currás, Ángeles Flórez
No abstract text is available yet for this article.
November 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135511/violaceous-pink-axillary-and-intertriginous-patches
#8
Ashley Gochoco, Laura M Schilling, Joya Sahu
No abstract text is available yet for this article.
November 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135508/new-histologic-finding-of-amyloid-insulin-bodies-at-an-insulin-injection-site-in-a-patient-with-diabetes
#9
Benjamin D Katzman, Peter Traum, Paul B Medline
Amyloidosis is a heterogeneous group of protein deposition diseases with more than 40 known clinical presentations. Localized amyloidosis occurs when the protein deposits exist in a singular location. Patients with diabetes mellitus who inject insulin at the same site can develop localized insulin-derived amyloidosis (AIns) at the injection site, which can be confused clinically with lipoma, lipohyperplasia, lipoatrophy, and fat necrosis. Histologic examination is performed to confirm localized AIns. We report a case of a patient with a long history of type 2 diabetes who presented with a subcutaneous mass in the abdomen at a preferred insulin injection site...
November 7, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135507/immunohistochemical-and-fluorescence-in-situ-hybridization-analysis-of-myc-in-a-series-of-17-cutaneous-angiosarcomas-a-single-center-study
#10
Celia Requena, Luis Rubio, Javier Lavernia, Isidro Machado, Beatriz Llombart, Onofre Sanmartín, Víctor Traves, Carlos Guillén, Julia Cruz
Cutaneous angiosarcoma (AS) is an uncommon aggressive sarcoma whose incidence is rising because of the increasing use of radiation therapy, especially in breast cancer. The few studies on the relevance of prognostic factors, such as MYC status in cutaneous AS, have reported inconclusive findings, with some authors reporting MYC amplification only in postirradiation and lymphedema-associated AS and others reporting evidence of MYC amplification in idiopathic AS. We analyzed 17 cases of cutaneous AS (6 idiopathic AS, 10 postirradiation AS, and 1 lymphedema-associated AS) treated at our institute between 2000 and 2015...
November 7, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135512/cytokeratin-profile-of-basal-cell-carcinomas-according-to-the-degree-of-sun-exposure-and-to-the-anatomical-localization
#11
Ma Reyes García-de-la-Fuente, Maria Santacana, Joan Valls, Felip Vilardell, José Manuel Fernández Armenteros, Ramon Pujol, Eloi Gari, Josep Manel Casanova
Basal cell carcinoma (BCC) seems to originate from ultraviolet light-induced mutations involving the bulge or the outer sheath of the hair follicle cells. However, the etiopathogenic mechanisms involved in the development of these tumors in nonphotoexposed and in hairless areas remain unclear. The cytokeratin (CK) profile (including CK5/6, CK7, CK14, CK15, CK17, and CK19) from a series of different BCC subtypes developing in sun-exposed and non-sun-exposed areas, including hairless regions, was evaluated. The authors have observed that CK7 expression in BCC is associated with the anatomical localization of the tumor and its sun-exposition, but not with other factors such as histological subtype...
November 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29095742/holocrine-poroma-a-distinctive-adnexal-tumor
#12
Marcelo G Horenstein, Marina P Sandoval, Yungtai Lo, Jack Jacob
There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements. Folliculosebaceous poroid tumors (FSPT) had basaloid and squamous cells (100%), ducts with steatocystoma-like cuticles and holocrine secretions (89.6%), infundibular follicular structures (66.7%), and entrapped sebocytes (56.3%). No definite apocrine decapitation secretions in FSPT were found...
November 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29140807/persistent-upper-lip-swelling-in-a-young-woman
#13
Jennifer Y Wang, Kerri E Rieger
No abstract text is available yet for this article.
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29140806/florid-granuloma-annulare-like-reaction-in-regional-lymph-nodes-after-regression-of-red-pigment-in-tattoos
#14
Michael D Carter, Jonathan Trites, Shelly A McNeil, Noreen N M Walsh, Martin J Bullock
A healthy 50-year-old woman had a tattoo performed on the posterior aspect of her neck and another on the dorsum of her left foot. Several weeks later, she noted redness, tenderness, and intense pruritis at both tattoo sites. Treatment with cephalexin and hydrocortisone cream was instituted, without success. Within a few months, the red, but not black, pigment had disappeared from both tattoos and was replaced by pale areas of scarring. Persistently enlarged left supraclavicular and suboccipital lymph nodes were excised 7 and 10 months after receipt of the tattoos, respectively...
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135502/the-crown-jewel-an-enigmatic-solitary-mass-of-follicular-origin-challenge
#15
Simon F Roy, Feras M Ghazawi, Sergio González Bombardiere
No abstract text is available yet for this article.
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29095741/eccrine-centric-melanocytic-nevus
#16
Raymond M Fertig, Adar Berghoff, Jessica Cervantes, Evan Darwin, Drazen Jukic
Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. The patient was a 50-year-old African American woman who noticed a new mole on her foot that began as a dark speck but quickly grew larger. The lesion was excised to exclude the possibility of melanoma...
October 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29095740/melanocytic-matricoma-with-consumption-of-the-epidermis-an-atypical-histologic-attribute-or-a-malignant-variant
#17
Caroline Y Winslow, Ivan Camacho, Carlos H Nousari
Melanocytic matricoma is a recently described cutaneous adnexal tumor composed of matrical and supramatrical cells admixed with pigmented dendritic melanocytes, thought to recapitulate the anagen bulb of the hair follicle. We report a case of a 75-year-old white man, which demonstrates consumption of the epidermis that is defined as thinning of the epidermis with attenuation of the basal and suprabasal layers and loss of the normal rete architecture in areas of direct contact with neoplastic cells. It has been associated with aggressive histologic features in melanoma and likely represents an early phase of ulceration due to attenuation...
October 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29095739/a-morbidly-obese-man-with-an-enlarging-right-thigh-mass
#18
Claudia Salgado, Ivy John
No abstract text is available yet for this article.
October 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29095738/cytotoxic-cd8-granulomatous-cutaneous-t-cell-lymphoma-associated-with-human-immunodeficiency-virus-infection-a-diagnostic-challenge
#19
Eduardo Rozas-Muñoz, Ana Mozos, Ramón M Pujol, Justyna Szafranska, Maria P García-Muret, Silvana Novelli, Adriana García-Herrera
No abstract text is available yet for this article.
October 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29135509/unilesional-follicular-mycosis-fungoides-report-of-6-cases-and-review-of-the-literature
#20
Cynthia M Magro, Gladys H Telang, Shabnam Momtahen
Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion...
October 24, 2017: American Journal of Dermatopathology
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