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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/29771690/heavily-pigmented-epithelioid-melanoma-with-loss-of-protein-kinase-a-regulatory-subunit-%C3%AE-expression
#1
Jarish N Cohen, Jessica A Spies, Fawn Ross, Angela Bohlke, Timothy H McCalmont
Heavily pigmented melanocytic neoplasms are genotypically and phenotypically diverse. Recently, a subset of this histopathologic spectrum was shown to harbor recurrent genetic alterations in the gene-encoding protein kinase A regulatory subunit-α (PRKAR1A). To date, no histopathologic descriptions of melanomas arising from this pathway have been described. We present a case of a darkly pigmented papule arising on the posterior neck of a 28-year-old man. Microscopically, the heavily pigmented compound melanocytic proliferation was centered in the dermis with permeation into the superficial subcutis...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29771689/oncocytic-melanoma-a-study-of-a-rare-entity
#2
Ludvik R Donner, Valdemar Maximo
The authors report the second case of oncocytic melanoma, one of the rarest known melanoma variants. The diagnosis was established by Fontana stain positivity, expression of S100 protein as well as gp100/HMB45, and demonstration of numerous mitochondria by ultrastructure. Because it is known that some oncocytic tumors of the thyroid gland and kidney contain point mutations and common deletions of mitochondrial DNA, the complete mitochondrial DNA of the reported oncocytic melanoma was also studied. It was normal except for 2 private separate point mutations, predicted to be not pathogenic, which do not seem to play any role in the tumor phenotype...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#3
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742558/a-polypoid-lesion-on-the-left-knee
#4
Rachel E Ward, Darius R Mehregan, Viktor N Goncharuk, Liaqat Ali
No abstract text is available yet for this article.
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742557/cutaneous-squamous-cell-carcinoma-with-sclerosing-features-an-uncommon-and-potentially-aggressive-variant
#5
Shira Ronen, Alejandro A Gru, Mary M Noland, David M Rowe, Mark R Wick
Sclerosing squamous cell carcinoma (SCC), also known as "desmoplastic" SCC, is a rare subtype of cutaneous malignancy. This variant is clinically significant because it is associated with an increased risk of local recurrence and metastasis. We herein present 16 examples of sclerotic SCC of the skin in 8 men and 3 women, with a median age of 66 years. The most common site of origin for this tumor is the skin of the head and neck, including the scalp (5 tumors in 2 different patients), forehead (3 cases), nasal ala (2 cases), neck (2 cases in the same patient), ear (2 cases), cheek (1 case), and chest (1 case)...
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742556/primary-cutaneous-adenoid-cystic-carcinoma-connecting-to-the-epidermis
#6
Masahiro Hayashi, Yoriko Yaguchi, Ken Okamura, Ami Hemmi, Yuko Abe, Hiromasa Takahashi, Tomoya Kato, Shin-Ichi Ansai, Mitsunori Yamakawa, Tamio Suzuki
No abstract text is available yet for this article.
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742555/primary-subcutaneous-synovial-sarcoma-first-reported-subcutaneous-case-showing-tle1-immunoreactivity
#7
Victoria Alegría-Landa, Laura Nájera, Dolores Suárez Massa, Gastón Roustan, María Del Río, Heinz Kutzner, Luis Requena
Synovial sarcoma (SS) accounts for 5%-10% of all soft tissue sarcomas. It is a well-defined soft tissue neoplasm with biphasic and monophasic histologic subtypes and unknown histogenesis. It usually occurs in the extremities, especially the thigh-knee region of young adults. Recurrences are frequent and distant metastasis developed in approximately half of the patients. SSs are characterized by a recurrent nonrandom chromosomal translocation, t(X; 18) (p11; q11), which is considered the primary genetic event in more than 90% of cases...
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742554/purpuric-plaque-overlaying-femoral-bypass-surgery-scar-question
#8
Simon F Roy, Julie Mireault, Danielle Bouffard, Geneviève Fortier-Riberdy, Annie Bélisle
No abstract text is available yet for this article.
May 8, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742561/bowen-disease-with-sebaceous-differentiation-a-case-report-and-immunohistochemical-analysis-of-adipophilin-and-cytokeratin-1
#9
Takeshi Namiki, Keiko Miura, Hiroo Yokozeki, Shin-Ichi Ansai
Bowen disease with sebaceous differentiation has been rarely documented to date. Here, we present a case of Bowen disease with sebaceous differentiation. A 67-year-old man presented with a 6.0 × 3.5 cm erythematous plaque adjacent to a 7.0 × 3.0 cm erythematous plaque on his left abdomen. Dermoscopy revealed yellow structureless areas and dotted vessels on a pink homogenous background in addition to surface scales. Histopathological examination of the upper erythematous plaque showed parakeratosis and acanthosis with proliferation of atypical keratinocytes in the epidermis...
May 3, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742560/two-cases-of-chronic-candidiasis-in-keratitis-ichthyosis-deafness-syndrome
#10
Diana Bartenstein, Hye Jin Chung, Sadaf Hussain
Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis that typically results from mutations of the GJB2 gene or, less commonly, the GJB6 gene. Patients with KID syndrome are at higher risk of malignancy and infections. Here, we present 2 patients with KID syndrome who developed verrucous plaques. Given that patients with KID syndrome are at high risk of developing squamous cell carcinoma, biopsies were performed. Both cases revealed histologic findings of marked papillomatous epidermal hyperplasia with numerous fungal spores and pseudohyphae in the stratum corneum...
May 3, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742559/pd-l1-expression-is-increased-in-metastasizing-squamous-cell-carcinomas-and-their-metastases
#11
Irene García-Díez, Eugenia Hernández-Ruiz, Evelyn Andrades, Javier Gimeno, Carla Ferrándiz-Pulido, Mireia Yébenes, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz, Agustí Toll
Programmed cell death ligand 1 (PD-L1) expression by tumor cells plays an important role in the inhibition of T cell-mediated immune response in cancer. PD-L1 expression by tumor cells has been linked to poor prognosis in a wide variety of cancers. However, PD-L1 expression in cutaneous squamous cell carcinoma (cSCC) has been scarcely studied, and its role as a prognosis biomarker remains controversial. The association of PD-L1 expression and the metastatic risk in a series of cSCC was assessed. PD-L1 and CD8 immunostainings of full excision sections of 99 primary tumors and 24 lymphatic metastases were semiquantitatively evaluated...
May 3, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742553/hpv6-and-hpv11-genome-methylation-in-condyloma-accuminatummeasured-by-bisulfite-sequencing
#12
Dan-Dan Wu, Fu-Quan Long, Jing Gao, Li Zhong, Chang Sun
No abstract text is available yet for this article.
May 2, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29742552/subcutaneous-panniculitis-like-t-cell-lymphoma-versus-lupus-erythematosus-panniculitis-distinction-by-means-of-the-periadipocytic-cell-proliferation-index
#13
Panitta Sitthinamsuwan, Penvadee Pattanaprichakul, Jitsupa Treetipsatit, Tawatchai Pongpruttipan, Sanya Sukpanichnant, Laura B Pincus, Timothy H McCalmont
The distinction between subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus (LE) panniculitis is remarkably challenging. Rimming by lymphocytes with an elevated Ki-67 cell proliferation index has been forwarded as a potential diagnostic finding in biopsies of SPTCL but has not been rigorously compared with biopsies from patients with LE panniculitis. Nineteen and 17 examples of SPTCL and LE panniculitis, respectively, were evaluated for periadipocytic rimming by lymphocytes expressing Ki-67, CD8, and βF1 and for attributes associated with LE, including clusters of CD123-positive cells...
May 2, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697424/a-case-of-oral-florid-papillomatosis-verrucous-carcinoma-with-lack-of-evidence-for-human-papillomavirus-involvement
#14
David Dias-Polak, Zipi Kra-Oz, Moran Szwarcwort-Cohen, Aviv Barzilai, Reuven Bergman
No abstract text is available yet for this article.
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697423/using-stratum-corneum-thickness-and-configuration-to-distinguish-lichenoid-dermatoses
#15
Amanda F Marsch
BACKGROUND: Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions. OBJECTIVE: To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses. METHODS: A retrospective study was performed. A total of 305 cases (55 lichenoid keratosis, 51 lichen planus, 7 hypertrophic lichen planus, 40 lichenoid drug eruption, 19 lichenoid graft-vs.-host disease, 14 hypertrophic lupus, 46 lichenoid actinic keratosis, 73 lentigo maligna) fulfilled the selection criteria...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697422/keratoacanthomatous-changes-unifying-the-histologic-spectrum-of-actinic-granuloma
#16
Jennifer N Harb, Jessica E Kalen, Sylvia Hsu, Abdul Hafeez Diwan, Antoanella Calame, Kiran Motaparthi
Actinic granuloma (AG) manifests as annular plaques on sun-damaged skin. There remains no universal consensus on the nosology, etiology, or clinicopathologic criteria of AG as a distinct entity. Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. It is not uncommon, however, to encounter overlapping histological features of other granulomas, such as granuloma annulare and necrobiosis lipoidica, confounding the diagnosis of this controversial entity...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697421/a-case-report-and-literature-review-of-scrub-typhus-with-acute-abdomen-and-septic-shock-in-a-child-the-role-of-leukocytoclastic-vasculitis-and-granulysin
#17
Po-Hsiung Chang, Yu-Pin Cheng, Po-Sheng Chang, Chiao-Wei Lo, Lung-Huang Lin, Chin-Fang Lu, Wen-Hung Chung
Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. It has various systemic manifestations, including GI symptoms. In some, the illness progresses to multiorgan dysfunction syndrome and death...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697420/poxvirus-induced-vascular-angiogenesis-mimicking-pyogenic-granuloma
#18
Zehra Aşiran Serdar, Şirin Yaşar, Cuyan Demirkesen, Ezgi Aktaş Karabay
The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. The vascular endothelial growth factor-like viral gene product is expressed early during infection and could be responsible for the induction of endothelial proliferation...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29697419/protruding-hyperkeratotic-tumor-underneath-the-big-toe-nail-challenge
#19
Ga Ram Ahn, Ji Yeon Hong, Kapsok Li, Kui Young Park
No abstract text is available yet for this article.
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29672364/role-of-direct-immunofluorescence-in-cutaneous-small-vessel-vasculitis-experience-from-a-tertiary-center
#20
Khushboo Lath, Debajyoti Chatterjee, Uma Nahar Saikia, Biman Saikia, Ranjana Minz, Dipankar De, Sanjeev Handa, Bishan Radotra
Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. All histologically proven cases of cutaneous vasculitis over the past two and half years were retrospectively analyzed along with their clinical and DIF findings (IgG, IgA, IgM, and C3). Within this study period, a total of 198 cases of small-vessel vasculitis were diagnosed based on skin biopsy and DIF findings...
April 17, 2018: American Journal of Dermatopathology
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