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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/28644174/resident-education-in-molecular-and-genetic-testing-in-dermatology-an-opportunity-not-to-be-missed
#1
Michael J Murphy, Kristen Russomanno
No abstract text is available yet for this article.
June 16, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28609347/collagen-anomalies-as-clues-for-diagnosis-part-2
#2
Sergio Santos-Alarcón, Omar Francisco López-López, Miguel Ángel Flores-Terry, Dante Villamil-Cerda, Luis Jesús Allemant-Ortiz, Juan José Ríos-Martín, Victoria Alegría, Luis Requena
BACKGROUND: Collagen is the most abundant protein in the body and the main structural component of the skin. OBJECTIVE: To provide a review of the histopathology of collagen alterations and to propose a classification with the most important types of collagen anomalies in dermatopathology. The authors describe some of the main morphological clues of collagen anomalies for specific diagnosis of some cutaneous inflammatory and neoplastic conditions. METHODS: The authors review histopathologic collagen anomalies, concerning both morphology and disposition in some inflammatory and neoplastic cutaneous conditions, and they review previous terminology and proposed a classification of the most important types of collagen anomalies that can be seen in dermatopathological practice...
June 6, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28609346/plaque-like-pilar-sheath-acanthoma-histopathologic-and-immunohistochemical-study-of-3-unusual-cases
#3
Margarita Jo-Velasco, Araceli Corrales-Rodríguez, Laura Francés-Rodríguez, Victoria Alegría-Landa, Itziar Eraña-Tomás, Arno Rütten, Luis Requena
Pilar sheath acanthoma is an uncommon, benign follicular neoplasm that frequently presents as a solitary lesion. This neoplasm usually appears on the skin around the upper lip of elderly patients. Histopathologically, the neoplasm usually shows a cystic configuration with epithelial lobules resembling to those of the outer root sheath of the hair follicle at the level of the isthmus emanating radially from the cyst wall. We present 3 peculiar cases of a pilar sheath acanthoma showing a plaque-like architecture because the lesions exhibited a horizontal configuration...
June 6, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28609343/extensive-hyperkeratotic-scaly-papules-and-plaques-in-a-56-year-old-woman
#4
Michael A Montuno, Kristen E Schmits, Tania M Gonzalez-Santiago
No abstract text is available yet for this article.
June 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28609342/cutaneous-collagenous-vasculopathy-report-of-two-cases-presenting-as-disseminated-telangiectasias-and-review-of-the-literature
#5
Laure Bondier, Mathilde Tardieu, Perrine Leveque, Isabelle Challende, Nicole Pinel, Marie T Leccia
Cutaneous collagenous vasculopathy is a recently described idiopathic microangiopathy characterized by acquired diffuse cutaneous telangiectasias and specific histological features: dilated capillaries in the superficial dermis, with walls thickened by hyaline material containing collagen IV by immunohistochemistry. The authors describe 2 cases and review all cases reported in the literature to date, 34 cases including our own. Cases were mainly observed in women (sex ratio 0.41), median age 63.5 (16-85). Hypertension and diabetes seem more frequent in these patients than in the general population...
June 1, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28609345/histopathologic-findings-of-cutaneous-hyperpigmentation-in-addison-disease-and-immunostain-of-the-melanocytic-population
#6
Angel Fernandez-Flores, David S Cassarino
The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead...
May 31, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28570392/primary-cutaneous-small-cell-variant-of-anaplastic-large-cell-lymphoma-a-case-series-and-review-of-the-literature
#7
Cynthia M Magro, Shabnam Momtahen, Maija Kiuru
Primary cutaneous anaplastic large cell lymphoma (ALCL), similar to systemic ALCL, has as its histomorphologic hallmarks cohesive sheets of large lymphoid cells expressing CD30. Several morphologic variants of systemic ALCL have been reported, including the common (classic) type, lymphohistiocytic, and small cell variants. The small cell variant of ALCL is characterized by a predominant cytomorphology which is unexpected for ALCL, being in the context of a small- to medium-sized hyperchromatic atypical lymphocyte...
May 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28570390/lymph-node-metastasis-with-both-components-of-combined-cutaneous-squamous-cell-carcinoma-merkel-cell-neuroendocrine-carcinoma
#8
Jorge Navarrete, Natalia Gugelmeier, María Eugenia Mazzei, Sergio González, Juan J Barcia, Julio Magliano
No abstract text is available yet for this article.
May 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28570391/spiradenocarcinoma-a-comprehensive-data-review
#9
Roxane D Staiger, Birgit Helmchen, Claudia Papet, Diana Mattiello, Urs Zingg
INTRODUCTION: Spiradenocarcinomas (SCs) are rare and potentially aggressive skin adnexal tumors. Optimal treatment has not yet been established. Experiences with this carcinoma are mostly presented in case reports and few case series. OBJECTIVE: To generate to a synopsis of published data on SC with regard to diagnostic procedures, treatment, and outcome. RESULTS: Median patient age was 60 years and sex distribution was balanced. Tumor manifestations were evenly distributed within the sweat gland carrying skin...
May 16, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28521332/tuberculosis-of-lip-an-unusual-presentation
#10
Abhimanyu Sharma, Vinod K Arora
No abstract text is available yet for this article.
May 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28509701/educational-gaps-in-molecular-diagnostics-genomics-and-personalized-medicine-in-dermatopathology-training-a-survey-of-us-dermatopathology-fellowship-program-directors
#11
Kristin Torre, Kristen Russomanno, Tammie Ferringer, Dirk Elston, Michael J Murphy
BACKGROUND: Molecular technologies offer clinicians the tools to provide high-quality, cost-effective patient care. We evaluated education focused on molecular diagnostics, genomics, and personalized medicine in dermatopathology fellowship. DESIGN: A 20-question online survey was emailed to all (n = 53) Accreditation Council for Graduate Medical Education (ACGME)-accredited dermatopathology training programs in the United States. RESULTS: Thirty-one of 53 program directors responded (response rate = 58%)...
May 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475520/mucocutaneous-hyperpigmentation-in-a-patient-with-a-history-of-both-minocycline-and-silver-ingestion
#12
Angel Fernandez-Flores, Thao Nguyen, David S Cassarino
Minocycline is a derivative of tetracycline. It has been widely used in dermatology for the treatment of acne and rosacea. One of its adverse effects is pigmentation of various body tissues. Clinically, 3 main distinct types of hyperpigmentation by minocycline have been distinguished: type I, with blue-gray to black pigment on the face in areas of scarring or inflammation; type II, with blue-gray pigment on normal skin of the legs, forearms and on the shins; and type III, with a diffuse muddy-brown discoloration in areas of sun exposure...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475519/genomic-assessment-of-blitz-nevi-suggests-classification-as-a-subset-of-blue-nevus-rather-than-spitz-nevus-clinical-histopathologic-and-molecular-analysis-of-18-cases
#13
Maria C Isales, Alexandra M Haugh, Jeffrey Bubley, Anna E Verzì, Bin Zhang, Emily Kudalkar, Christina Y Lee, Pedram Yazdan, Joan Guitart, Pedram Gerami
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these lesions have different prognostic markers. In this study, we assess the clinical, morphological, and genomic changes in 18 cases of Blitz nevi/tumors to better characterize this subset of neoplasms and determine their optimal genomic classification...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475518/palisaded-neutrophilic-and-granulomatous-dermatitis-interstitial-granulomatous-dermatitis-overlap-a-striking-clinical-and-histologic-presentation-with-burning-rope-sign-and-subsequent-mirror-image-contralateral-recurrence
#14
Malan Kern, Mallory B Shiver, Kristen M Addis, Jerad M Gardner
Palisaded neutrophilic and granulomatous dermatitis and interstitial granulomatous dermatitis are uncommon granulomatous dermatoses that often arise in association with rheumatoid arthritis. These 2 entities have overlapping features and may exist on a spectrum. We report an intriguing case of a 53-year-old man with advanced rheumatoid arthritis who presented with a large indurated painful truncal plaque with a palpable cord in addition to a papulonodular eruption on his dorsal hands. Furthermore, our patient had a recurrence in a near-identical mirror-image pattern on the contralateral trunk...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475517/hailey-hailey-disease-with-coexistent-herpes-virus-infection-insights-into-the-diagnostic-conundrum-of-herpetic-pseudoherpetic-features-in-cutaneous-acantholytic-disorders
#15
Claire S Leitch, Anusha P Panthagani, Michael J Tidman, Asok Biswas
The specific histopathologic diagnosis of a primary acantholytic disorder takes into account the distribution and extent of acantholysis, presence or absence of dyskeratosis, nature of the dermal inflammatory cell infiltrate, and immunofluorescence findings. Herpes virus infection is a common cause of secondary acantholysis where distinctive viral cytopathic changes aid in making it a clear-cut diagnosis in majority of cases. We present a case of coexistence of Hailey-Hailey disease and herpes simplex virus infection to compare and contrast their histopathologic features...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475516/unusual-case-of-dactylitis-with-nail-unit-involvement
#16
Isabelle Moulonguet, Philippe Abimelec
No abstract text is available yet for this article.
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475515/annular-lichenoid-dermatitis-of-youth-report-of-a-case-with-lichen-planus-like-features
#17
Anna M Cesinaro
Annular lichenoid dermatitis of youth (ALDY), a dermatosis with peculiar clinical and pathological features, represents still a debated entity, given its similarity, among others, with mycosis fungoides. A case of ALDY in a 50-year-old male patient is reported. Clinically, the patient presented an oval scleroderma-like plaque on the right flank. Histology and immunohistochemistry showed the classic appearance described in ALDY. T-cell receptor rearrangement was absent. Interestingly, a focus consistent with lichen planus was observed...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475514/recurrent-cutaneous-angiosarcoma-of-the-scalp-with-aberrant-expression-of-s100-a-case-report
#18
Laura Macías-García, Concepción Lara-Bohorquez, Enrique Jorquera-Barquero, Juan J Ríos-Martín
Angiosarcoma (AS) is a malignant mesenchymal neoplasm of endothelial origin with a predominantly lymphatic immunophenotype, which accounts for less than 1% of all sarcomas. Cutaneous AS of the scalp is associated with high rates of local recurrence and a poor prognosis. Histologically, poorly differentiated AS often comprises solid epithelioid cells, although rare variants involving spindle cells have been reported; diagnosis requires immunohistochemical analysis using vascular cell markers. We report on a cutaneous spindle-cell AS of the scalp in a female patient; key features included spontaneous regression after biopsy, local recurrence 2 years later, and aberrant nuclear staining for S100 protein in an area of the tumor not expressing CD34 or D2-40...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475513/nodular-sclerodermatous-chronic-cutaneous-graft-versus-host-disease-gvhd-a-new-clinicopathological-variant-of-cutaneous-sclerodermatous-gvhd-resembling-nodular-keloidal-scleroderma
#19
Lucía Prieto-Torres, Francesca Boggio, Alexandra Gruber-Wackernagel, Lorenzo Cerroni
Cutaneous chronic graft-versus-host disease (GvHD) has a broad spectrum of clinicopathological presentations, the most common ones being poikiloderma, lichen planus-like eruptions, lichen sclerosus-like lesions, morphea-like plaques, and deep sclerosis. New forms of chronic cutaneous GvHD with different clinicopathological characteristics have been described, most of them mimicking cutaneous manifestations of autoimmune diseases. We report the case of a 35-year-old man who underwent allogenic stem cell transplantation for a therapy-associated acute myeloid leukemia and developed an acute GvHD with involvement of skin and gastrointestinal tract...
April 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28475512/a-new-firm-solitary-nodule-in-a-patient-with-hiv-aids-question
#20
Andrew S Fischer, Neda Black, Brandon McNally, Joshua Wisell
No abstract text is available yet for this article.
April 25, 2017: American Journal of Dermatopathology
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