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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/28067672/evolution-of-fibroblastic-connective-tissue-nevus-in-an-infant
#1
Michael C Lynch, Thomas D Samson, Andrea L Zaenglein, Catherine G Chung
Fibroblastic connective tissue nevus (FCTN) is a rare and recently described neoplasm of fibroblastic/myofibroblastic lineage. We report a case of a 1-month-old healthy male infant who presented with a dermal plaque on the upper chest since birth. A punch biopsy demonstrated a dermal spindle-cell neoplasm with variable smooth muscle actin positivity and negative staining for CD34, consistent with myofibroma. Over the course of the next year, the remaining lesional tissue exhibited clinical softening and a surgical excisional specimen revealed histologic findings distinct from the original biopsy...
January 5, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033156/tubulopapillary-cystic-adenoma-with-apocrine-differentiation-a-unifying-concept-for-syringocystadenoma-papilliferum-apocrine-gland-cyst-and-tubular-papillary-adenoma
#2
Shin-Ichi Ansai, Takashi Anan, Takaya Fukumoto, Hidehisa Saeki
Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with apocrine differentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033155/lymph-node-involvement-by-a-clear-cell-nodular-hidradenoma-like-tumor-of-uncertain-malignant-potential
#3
Brandon Au, Konstantinos G Sidiropoulos, Danny Ghazarian, Michael Sidiropoulos
No abstract text is available yet for this article.
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#4
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033153/palisaded-granuloma-on-the-nose-an-atypical-presentation-of-granuloma-annulare
#5
Amílcar G Rodríguez, Jorge L Sánchez, Julio E Sánchez
Granuloma annulare (GA) is a common, asymptomatic dermatosis of unknown etiology. Many variants exist, among them widespread papules, papules in photodistribution, papules marked by tiny crusts ("perforating" GA), patches, plaques, and nodules (subcutaneous GA). The histopathological hallmark is a palisaded histiocytic infiltrate surrounding a central area of degenerated collagen with abundant mucin deposits. We report 2 women who presented with persistent nodules on the nose, which, on histopathological examination, showed a palisaded granuloma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28027081/altered-expression-of-toll-like-receptors-in-human-oral-epithelium-in-oral-lichenoid-reactions
#6
Abdelhakim Salem, Rabeia Mustafa, Dyah Listyarifah, Ahmed Al-Samadi, Goncalo Barreto, Dan Nordström, Kari K Eklund
Oral lichenoid reactions (OLRs) are chronic inflammatory lesions induced by contact with allergens. Toll-like receptors (TLRs) are members of pattern-recognition receptor superfamily. Once activated, TLRs induce production of cytokines and chemokines, thus leading to inflammatory reaction in host tissue. In the present study, we aimed to investigate the potential role of TLRs in the initiation and perpetuation of OLRs, in which TLRs induce innate immune responses mounted against allergens. TLRs, 1 through 10, were mapped in tissue samples obtained from healthy donors and OLR patients using real-time quantitative reverse transcription polymerase chain reaction, immunostaining, and image analyses...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28027080/carcinoid-like-labyrinthine-pattern-in-sebaceous-neoplasms-represents-a-sebaceous-mantle-phenotype-immunohistochemical-analysis-of-aberrant-vimentin-expression-and-cytokeratin-20-positive-merkel-cell-distribution
#7
Keisuke Goto, Takashi Anan, Takaya Fukumoto, Tetsunori Kimura, Noriyuki Misago
This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28030367/activation-of-pkc%C3%AE-and-pi3k-kinases-in-hypertrophic-and-nodular-port-wine-stain-lesions
#8
Rong Yin, Lin Gao, Wenbin Tan, Wei Guo, Tao Zhao, Jhon Stuart Nelson, Gang Wang
Port wine stain (PWS) is a congenital, progressive vascular malformation. Many patients with PWS develop hypertrophy and discrete nodularity during their adult life, but the mechanism(s) remain incompletely understood. In this study, we attempted to investigate activation status of PKCα, PI3K, PDPK1 and PLC-γ and protein levels of PP2A and DAG to explore their potential roles in the formation of hypertrophic and nodular PWS lesions. We found phosphorylated levels of PKCα, PI3K, PDPK1, and PLC-γ and protein levels of PP2A and DAG showed moderate increases in the endothelial cells of hypertrophic PWS as compared to the adjacent normal skin...
December 20, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28002100/revisiting-pax-8-s-labeling-of-merkel-cell-carcinoma
#9
David P Wang, Ryan A Stevens, Joshua A Wisell
No abstract text is available yet for this article.
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28002099/achille-civatte-a-master-of-the-microscope
#10
Jannett Nguyen, Dorota Z Korta
Achille Civatte (1877-1956) was one of the most highly regarded dermatologists of the 20th century. We provide a succinct account of Civatte's academic life and contributions to the field of dermatopathology, in addition to briefly discussing his son, Jean Civatte, who himself became a highly regarded dermatologist.
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28002098/superficial-acral-fibromyxoma-of-the-toe-unusual-location-of-the-mixoid-variant
#11
Arianna Lamberti, Clelia Miracco, Michele Fimiani, Pietro Rubegni
Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that frequently involves the periungual and subungual regions of acral surfaces. Macroscopically, it appears as a flesh-colored dome-shaped solitary mass; microscopically, it consists of a moderately cellular proliferation of spindle-shaped fibroblast-like cells embedded in a myxocollagenous stroma and arranged in a loose storiform and focally fascicular pattern. The tumor cells are immunoreactive for CD34, epithelial membrane antigen, CD99, and CD10...
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27906695/metformin-induced-generalized-fixed-drug-eruption-with-cutaneous-hemophagocytosis
#12
Jose Luis Ramírez-Bellver, Joaquin Lopez, Elena Macias, Laura Fuertes, Irene Andres, Victoria Alegria, Ignacio Gimeno, Alejandra Perez, Yosmar Perez, Luis Requena
Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Only 2 cases due to metformin have been reported. Histopathologic features of FDE include vacuolar degeneration of the basal layer, necrotic keratinocytes, and superficial and deep perivascular lymphocytic infiltrate...
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27984233/dermatofibrosarcoma-protuberans-like-tumor-with-col1a1-copy-number-gain-in-the-absence-of-t-17-22
#13
Jad Saab, Ian M Rosenthal, Lu Wang, Klaus J Busam, Kishwer S Nehal, Mark A Dickson, Meera R Hameed, Travis J Hollmann
A 57-year-old woman presented with a 3-year history of a progressive firm plaque on the right cheek. Skin biopsies revealed a bland, storiform, spindle-cell proliferation involving the deep dermis and subcutaneous fat. By immunohistochemistry, the tumor cells were diffusely positive for CD34 and caldesmon with multifocal reactivity for epithelial membrane antigen and focal, weak staining for smooth muscle actin. Retinoblastoma protein expression was not detectable in tumor cells by immunohistochemistry. An interphase fluorescence in situ hybridization analysis for platelet-derived growth factor B (PDGFB) gene rearrangement was negative...
December 14, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27984232/balloon-cell-melanoma-and-its-metastasis-a-rare-entity
#14
Sonia Chavez-Alvarez, Alejandra Villarreal-Martinez, Ivett Miranda-Maldonado, Jorge Ocampo-Candiani, Veronica Garza-Rodriguez
Balloon cell melanoma (BCM) with metastasis is a rarely occurring neoplasia. The incidence of BCM is low, and hence, the frequency of these lesions presenting metastasis is even less frequent. This review exposes the balloon cell metastasis cases that have been published and a new case. These cases share the histopathological features but the location of initial melanoma, age and sex vary. It is relevant for the dermatologist and dermatopathologist to keep in mind the diagnosis of BCM and consider the possibility of it metastasizing as nonpigmented skin lesions...
December 10, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27930381/chronic-localized-fibrosing-leukocytoclastic-vasculitis-associated-with-lymphedema-intralymphatic-and-intravascular-lymphocytosis-and-chronic-myelogenous-leukemia-a-case-report-of-unilateral-erythema-elevatum-diutinum
#15
Juliana Atallah, Juan C Garces, Enrique Loayza, John A Carlson
One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV...
December 7, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27906694/follicular-malignant-melanoma-a-rare-morphologic-variant-of-melanoma-report-of-a-case-and-review-of-the-literature
#16
Iona Chapman, Sharon Horton, Wenhua Liu
Follicular malignant melanoma (FMM) is an exceedingly rare variant of melanoma. Only 8 cases have been reported in the literature thus far. Often bland on physical examination, FMM shows a striking histologic pattern, with atypical melanocytes sometimes consuming the entire follicle and extending into the dermis. Criteria have been suggested to help distinguish FMM from lentigo maligna melanoma; however, no clear criteria distinguish this cancer clinically. FMM cannot be distinguished from follicular metastases of melanoma based on histology, requiring close clinical correlation and detailed history taking on the part of the practitioner...
November 29, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27898475/pulmonary-signet-ring-cell-adenocarcinoma-metastatic-to-the-skin
#17
Alan S Boyd
Internal malignancies occasionally metastasize to the skin, usually imparting a poor prognosis. In men, pulmonary malignancies are the second most common offending tumor. Roughly, half such lesions are adenocarcinomas. A small subset of pulmonary adenocarcinomas exhibits signet-ring morphology. To date, a cutaneous metastasis arising from a pulmonary signet-ring cell adenocarcinoma has not been reported.
November 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27898474/is-it-a-metastatic-disease-a-case-report-and-new-understanding-of-rosai-dorfman-disease
#18
Carolina Martínez-Ciarpaglini, Carlos Monteagudo
No abstract text is available yet for this article.
November 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27898473/histopathological-and-clinical-findings-in-cutaneous-manifestation-of-erdheim-chester-disease-and-langerhans-cell-histiocytosis-overlap-syndrome-associated-with-the-brafv600e-mutation
#19
Julia Liersch, J Andrew Carlson, Jörg Schaller
The overlap of Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) is more common than it was generally accepted. Both diseases seem to be linked by a mutation in oncogenic BRAFV600E, probably an early event which occurs in bone marrow progenitor cells. In this article are described the clinical and histological findings in 2 cases of ECD-LCH overlap syndrome bearing the BRAFV600E mutation in both ECD and LCH lesions in bone and skin. In one case, lesions of ECD and LCH were situated directly site-to-site in the same bone section leading to the assumption of a common myeloid precursor cell for these diseases...
November 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27893468/linear-folliculotropic-cd30-positive-lymphomatoid-drug-reaction
#20
Yi-Chin Chen, Yu-Hung Wu
We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. The rash resolved rapidly after discontinuation of her medication 1 week later and did not recur. This case highlights the importance of clinicopathological correlation...
November 22, 2016: American Journal of Dermatopathology
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