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American Journal of Dermatopathology

Nicholas J Olson, Gregory D Seidel, Konstantinos Linos
No abstract text is available yet for this article.
October 12, 2017: American Journal of Dermatopathology
Adriana Guadalupe Peña-Romero, Sonia Toussaint-Caire, Yann Charli-Joseph, Fernando Dela Barreda-Becerril, Judith Domínguez-Cherit
Transient reactive aquagenic pseudokeratoderma is characterized by transient whitish and translucent papules after water exposure in palms and soles. We report 5 additional cases and their histopathologic features. Patient 5 showed a topography that had not been reported before; this demonstrates that it is not an exclusive condition of palms and soles. Patient 2 presents very subtle clinical findings, making difficult the diagnosis. And the other 3 patients have a typical presentation. Transient reactive aquagenic pseudokeratoderma has heterogeneous clinical features; in some cases, histopathologic findings, although subtle, help to confirm the diagnosis...
October 3, 2017: American Journal of Dermatopathology
Nathan T Harvey, Benjamin A Wood
No abstract text is available yet for this article.
October 2, 2017: American Journal of Dermatopathology
Mihaela Georgescu, Norbert Blödorn-Schlicht, Almut Böer-Auer
Induction of follicular germinative structures above a dermatofibroma (DF) is a common finding. Rarely, induction of a trichoblastoma in a DF has been observed. Here, we report the case of a desmoplastic trichoepithelioma induced by a DF. The lesion with clinical and histological appearance of a DF situated on the left dorsal foot showed an associated adnexal proliferation that fulfilled histopathological criteria of desmoplastic trichoepithelioma. Immunohistochemistry (Ber-EP4, Bcl-2, CK17, CK20, CK7, EMA, and Ki67) helped to confirm the diagnosis and to exclude possible differential diagnoses...
October 2, 2017: American Journal of Dermatopathology
Hiba Zaaroura, Reuven Bergman
Pseudolymphomatous reactions have been described to occur in tattoos. Most cases have exhibited T-cell predominance and polyclonal T-cell receptor gene rearrangements. One case with monoclonal IgH gene rearrangements progressed into B-cell lymphoma. Lichenoid infiltrates are commonly described but lymphoid follicles much less frequently. We report a case with mixed lichenoid and follicular T- and B-cell reaction to red tattoos. The histopathology and the immunohistochemical studies were constant with a mixed T- and B-cell pseudolymphoma, the IgH gene rearrangement study was polyclonal, but the T-cell receptor gene rearrangement study was monoclonal...
September 28, 2017: American Journal of Dermatopathology
Chibuike Enwereuzo, Luis Moral, Jean M Henneberry
Meningioma is a neoplasm of the meninges, which usually occurs in intracranial sites. Extracranial meningioma has been frequently reported in the sinonasal tract and skull bone, often as extension of intracranial meningiomas. Isolated heterotopic meningioma without contiguous intracranial lesion is extremely rare. A 56-year-old woman presented in December 2015 with 2 firm subcutaneous scalp masses; one in the left lateral (temporal) and the other in the left superior (parietal) region. The clinical impression was that of lipoma...
September 28, 2017: American Journal of Dermatopathology
Sarah M Beggs, Ben J Friedman, Davida Kornreich, Lauren Okon, Onder Alpdogan, Wenyin Shi, Joya Sahu
CD8 T-cell lymphomas comprise a wide spectrum of lymphomas, many which have yet to be formally classified. We present a case of a 43-year-old woman with an enlarging tumor distal to the distal interphalangeal joint of the fourth finger, compressing the underlying nail matrix. Magnetic resonance imaging showed bony involvement of the underlying distal phalanx. Histology showed a dense epidermotropic and pandermal infiltrate composed of medium-sized, uniformly pleomorphic lymphocytes with cleaved nuclei, which raised the possibility of primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma...
September 28, 2017: American Journal of Dermatopathology
Barbara Saenz Ibarra, Jason Meeker, Omid Jalali, Michael C Lynch
Cold panniculitis and perniosis are the most common cold-induced dermatologic disorders and are clinically characterized by indurated and erythematous nodules and plaques that develop at sites exposed to excessive cold and wet conditions. Cold panniculitis is most commonly seen in infants, but adult cases involving the thighs of equestrians are well known and have come to be known as equestrian cold panniculitis or equestrian perniosis. Recently, similar cases have been described in nonequestrian settings with the prolonged use of ice-packs or other cold-therapy devices...
September 27, 2017: American Journal of Dermatopathology
Corey Georgesen, Cynthia Magro
A rare variant of the eccrine spiradenoma, the giant vascular eccrine spiradenoma, has been characterized as a large circumscribed and sometimes hemorrhagic solitary tumor occurring in adults older than 50 years. Histopathologically, the lesion is comprised of distinct cell populations and cystic hemorrhagic glandular spaces. We present a 68-year-old Bengali man with a giant vascular eccrine spiradenoma and describe immunohistochemical features of this tumor. In addition, we highlight unique aspects of this case, including a rich myoepithelial component and focal pseudocapsular infiltration...
September 26, 2017: American Journal of Dermatopathology
Maya Hijazi, Robert Sprinkle, Omar Sangueza
No abstract text is available yet for this article.
September 26, 2017: American Journal of Dermatopathology
Valencia Long, Weisheng Tan, Siong See Joyce Lee, Tien Guan Steven Thng
Scleromyxedema is a rare disorder where patients may develop systemic manifestations such as monoclonal gammopathy, inflammatory polyarthritis, and esophageal and neurological dysfunction. Histologically, there may be atypical variants of scleromyxedema showing features resembling interstitial granuloma annulare. We report an unusual case of scleromyxedema with interstitial granulomatous pattern and highlight potential diagnostic pitfalls when encountered with such a variant.
September 20, 2017: American Journal of Dermatopathology
Caitlin G Purvis, Justin P Bandino, Dirk M Elston
No abstract text is available yet for this article.
September 20, 2017: American Journal of Dermatopathology
Delila Pouldar, Ashley Elsensohn, Francesca Ortenzio, Jessica Shiu, Michael McLeod, Sébastien de Feraudy
Erythema induratum (EI), or nodular vasculitis (NV), is a type of panniculitis that is often associated with vasculitis affecting various-sized veins, venules, and arteries in reaction to various causative factors. Historically, EI was highly linked to tuberculosis, but in 1946, Montgomery first proposed the term NV to describe cases of EI not associated with tuberculosis. Only 2 reports of NV associated with inflammatory bowel disease have been reported in the literature. The authors report a 60-year-old woman with Crohn's disease presenting with exacerbation of NV in the setting of vedolizumab therapy...
September 20, 2017: American Journal of Dermatopathology
Andrew Schuler, Emily Smith, Stephanie Chen, May P Chan, Paul W Harms
Psammoma bodies (PBs) are concentric, lamellated calcifications commonly observed in malignancies such as papillary thyroid carcinoma and serous carcinoma of the ovary in which they may serve prognostic value. PBs are rare in cutaneous squamous cell carcinoma (cSCC), with only 1 previously reported case. Here, we present 3 cases of cSCC displaying PBs. One case occurred in the setting of end-stage renal disease, whereas the other 2 cases were in patients who did not have comorbid conditions that might predispose to hypercalcemia and dystrophic calcification...
September 20, 2017: American Journal of Dermatopathology
Angel Fernandez-Flores, David S Cassarino
No abstract text is available yet for this article.
September 20, 2017: American Journal of Dermatopathology
Carlo Hendricks, Maite T Fernández Figueras, Julia Liersch, Maria-Teresa Martin-Urdà, Dolores López, Christoph Brochhausen, Christoph Röcken, Jörg Schaller
Light chain deposition disease (LCDD) is a rare systemic disorder with deposition of mostly monoclonal amorphous nonamyloid light chains in multiple organs. Renal involvement with rapidly progressing renal failure presents the dominant manifestation of LCDD. Approximately 20%-30% of patients show symptomatic cardiac or liver involvement. Cutaneous manifestations are extremely rare with only a few published cases. We report 2 additional cases of cutaneous LCDD without detectable systemic disease.
September 20, 2017: American Journal of Dermatopathology
Scott Walter, Lynne J Goldberg, Hye Jin Chung
No abstract text is available yet for this article.
September 20, 2017: American Journal of Dermatopathology
Jacob Stewart, Stephanie Bayers, Travis Vandergriff
Neutrophilic panniculitis is a relatively rare condition, characterized by predominantly neutrophilic inflammation in the subcutaneous fat. Rarely, neutrophilic panniculitis may be induced by chemotherapeutics or targeted molecular therapies, including the Bruton tyrosine kinase inhibitor ibrutinib. Previously reported cases of ibrutinib-induced panniculitis were suppressed with sustained low-dose steroid therapy while continuing ibrutinib therapy. To our knowledge, self-limiting panniculitis during ibrutinib therapy has not yet been described...
September 20, 2017: American Journal of Dermatopathology
Martyn Peck, Trevor W Beer, Tony Badrick, Benjamin A Wood
AIMS: To review the Royal College of Pathologists of Australasia (RCPA) Quality Assurance Program Dermatopathology module from 2005 to 2016 to assess diagnostic performance, changes over time, and areas of diagnostic difficulty. METHODS: The computerized records of the RCPA Dermatopathology subspecialist module were reviewed. Cases were categorized into groups including nonneoplastic disorders, neoplasms, and cases with multiple diagnoses. The performance of participants over time in each of these categories and in more specific areas (including melanocytic and adnexal neoplasms) was assessed...
September 20, 2017: American Journal of Dermatopathology
Mar Llamas-Velasco, Bruno Emilio Paredes
A 5-year-old girl presented with a facial butterfly rash that persisted for 5 months without arthralgia, fever, malaise, photosensitivity, or other symptoms. Lupus erythematosus was clinically suspected. All blood tests were negative or within normal values. Skin biopsy showed a dense nodular superficial and deep inflammatory infiltrate of lymphocytes that reaches subcutaneous tissue. The most striking histopathological finding was plasma cells with some perifollicular accentuation. Borrelia polymerase chain reaction assay of the tissue was positive, and we made the diagnoses of borrelia lymphocytoma mimicking butterfly rash of lupus erythematosus...
September 20, 2017: American Journal of Dermatopathology
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