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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/28719440/onychomatricoma-in-a-patient-with-extensive-vitiligo
#1
Emily L Behrens, Maliha Khan, Ashley Sturgeon, Michelle Tarbox
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719439/papulonodular-eruption-on-the-hands-in-a-patient-with-arthritis
#2
Trevor Hansen, Julie Dhossche, Stephanie Mengden Koon, Nicole Fett
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719438/comparative-analysis-of-chilblain-lupus-erythematosus-and-idiopathic-perniosis-histopathologic-features-and-immunohistochemistry-for-cd123-and-cd30
#3
Michael L Wang, May P Chan
Distinction of chilblain lupus erythematosus (CLE) from idiopathic perniosis (IP) could predict an underlying connective tissue disease; however, histopathologic discrimination of the two is difficult. Increased CD123 plasmacytoid dendritic cells and CD30 lymphocytes have been demonstrated in various forms of cutaneous lupus erythematosus and IP, respectively. To our knowledge, CD123 and CD30 have not been examined in CLE. Our objective was to identify helpful histopathologic and immunohistochemical features in distinguishing CLE and IP...
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719437/a-12-day-old-male-with-a-skin-tag-on-the-chin
#4
Syed M Abedi, Freya Van Driessche, Jaime Alexander, Edward Heilman, Sharon Glick
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719436/melanocytic-nevus-does-not-metastasize
#5
Kristin L Sticco, Alyssa Feiner, Sheng Chen
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719435/leukocytoclastic-vasculitis-and-dermal-perivascular-hemophagocytosis-associated-with-adalimumab-therapy-for-rheumatoid-arthritis
#6
Jun Muto, Jun Usami, Daisuke Watanabe
Tumor necrosis factor (TNF)-α inhibitors target TNF-α to effectively treat autoimmune inflammatory conditions, such as rheumatoid arthritis. However, many cases of cutaneous and systemic vasculitis related to TNF-α inhibitors have been reported in the literature. Here, the authors report the first case of a 61-year-old Japanese woman who developed leukocytoclastic vasculitis with cutaneous perivascular hemophagocytosis, which was related to elevated cytokines and immune complexes after initiating adalimumab for rheumatoid arthritis without evidence of hemophagocytic syndrome and rarely encountered in the skin...
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719434/primary-cutaneous-small-medium-cd4-t-cell-lymphoproliferative-disorder-occurring-in-a-patient-with-metastatic-melanoma
#7
Jonathan J Davick, Elizabeth Gaughan, Megan Barry, Alejandro A Gru
Therapeutic agents designed to stimulate the immune system are now cornerstones in the treatment of metastatic melanoma. These drugs promote lymphocyte growth and survival, which could plausibly result in clinical lymphoproliferative disorders. We report the case of a 62-year-old female with metastatic melanoma who developed primary cutaneous small/medium CD4 T-cell lymphoproliferative disorder (PC-SMTCL) after treatment with vemurafenib and recombinant high-dose interleukin-2 (IL-2). The patient developed a painless red papule behind the ear...
July 14, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28719433/cutaneous-atypical-neurofibroma-a-case-report-and-review-of-literature
#8
Nima Mesbah Ardakani, Ferlin Yap, Benjamin A Wood
No abstract text is available yet for this article.
July 13, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700374/exenatide-induced-panniculitis-utility-of-the-acid-fast-stain-to-identify-injected-microspheres
#9
Vidal I Claudia, Chaudhry Sofia, Burkemper M Nicole
No abstract text is available yet for this article.
July 7, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700373/retiform-purpura-after-transcatheter-arterial-chemoembolization-a-case-report
#10
Trevor Hansen, Keith Olsen, Kevin White, Jesse Keller
Cutaneous complications secondary to transcatheter arterial chemoembolization (TACE) are exceptionally rare and may occur because of nontarget embolization of terminal vessels supplying the skin. We present a patient who developed painful retiform purpura on the right flank shortly after TACE for treatment of hepatocellular carcinoma. Biopsy revealed intravascular tan to yellow amorphous spherical structures within the dermis, confirming the presence of foreign material within these vessels. The authors review the literature and discuss previous cases of skin lesions manifesting after TACE, as well as potential factors influencing the probability of cutaneous complications...
July 6, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700372/immunohistochemical-demonstration-of-parvovirus-b19-viral-protein-2-in-periflexural-exanthema-in-an-adult-supporting-antibody-dependent-enhancement-as-means-of-endothelial-uptake-of-the-virus
#11
Carlos Santonja, Úrsula Pielasinski, Jorge Polo, Heinz Kutzner, Luis Requena
Human parvovirus B19 (B19V) causes a number of skin exanthemas and has been related to both cutaneous and systemic diseases. Tropism of the virus for the rapidly proliferating erythroid progenitor cells in the bone marrow and fetal liver explains the pathogenesis of anemia and fetal hydrops. The cutaneous lesions of erythema infectiosum and other B19V-related exanthemas have been attributed to the deposition of immune complexes in the skin. We report on the immunohistochemical detection of B19V protein in the cytoplasm of dermal endothelial cells in a case of periflexural exanthema in a 28-year-old woman...
July 6, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700376/eruptive-multifocal-cutaneous-mucinous-cysts
#12
Deshan F Sebaratnam, Nita Agar, Wendy Cooper, Louise Jackett
Cutaneous cysts lined by mucinous epithelium are rare entities. We report an unusual case of a 60-year-old female patient who presented with a 2-month history of eruptive cystic papules on her right thigh. Histopathologic study showed multiple, multiloculated cysts located in the dermis lined by nonciliated mucinous epithelium. The cyst lining was positive for AE1/AE3, CK7, CK20, and GCDFP15. Patchy positivity was noted on the p53 stain. Attenuated Sox10 positive cells were identified, raising the possibility of sweat duct origin; however, no myoepithelial layer was identified by p63 staining...
July 4, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700377/in-response
#13
Luis Requena, Philip E LeBoit
No abstract text is available yet for this article.
June 29, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28700375/comparative-study-of-shrinkage-in-human-skin-artificial-human-skin-and-mouse-skin
#14
Gonzalo Blasco-Morente, Antonio Lizana-Moreno, Ana Fernández-González, José Aneiros-Fernández, Miguel Arrabal, José M García, Agustín Buendía-Eisman, Jesús Tercedor-Sánchez, Salvador Arias-Santiago
INTRODUCTION: The shrinkage of surgical specimens (SS) is known in human skin (HS) but has not been studied in an artificial skin (AS) or mouse skin (MS). OBJECTIVES: To quantify the degree of shrinkage of SS and establish its timing in HS and an in vitro and animal model to explore the possible causes of this phenomenon. METHODOLOGY: We collected 100 SS of HS, 50 SS of AS synthesized with fibrin-agarose biomaterials and 21 SS of MS. The width and length of specimens were measured before the surgical excision (pre-SE), at 5 minutes postsurgery (ex vivo), and after 24 hours of fixation in formalin (postfixation)...
June 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28692465/epidermotropic-bullous-and-erosive-metastatic-melanoma
#15
David Dias-Polak, Gil Bar Sela, Reuven Bergman
No abstract text is available yet for this article.
June 21, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654469/the-histopathological-spectrum-of-pseudolymphomatous-infiltrates-in-cutaneous-lupus-erythematosus
#16
Amanda Pereira, Gerardo Ferrara, Paola Calamaro, Carlo Cota, Cesare Massone, Francesca Boggio, Lucia Prieto-Torres, Lorenzo Cerroni
The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Of the 15 cases, 9 (60%) were characterized by dense nodular infiltrates. Three cases (20%) showed an angiocentric pattern with cytological atypia of lymphoid cells; 2 cases (13...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654468/bullous-pemphigoid-use-of-c4d-immunofluorescent-staining-in-a-case-with-repeated-negative-conventional-direct-immunofluorescence-studies
#17
Sarah S Kassaby, Alexander Hicks, Stuart Leicht, George A Youngberg
Direct immunofluorescence (DIF) using frozen section material from a fresh/preserved perilesional biopsy is the gold standard for the immunopathologic diagnosis of bullous pemphigoid (BP). DIF in BP shows linear dermoepidermal junction (DEJ) staining for C3, with or without staining for IgG. In some situations, only a formalin-fixed lesional biopsy is obtained (with no fresh/preserved perilesional biopsy for DIF). In this setting, paraffin section C4d immunohistochemistry has proven to be diagnostically useful, demonstrating linear DEJ positivity for C4d...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654467/a-young-woman-with-an-erythematous-rash-fever-tachycardia-and-pancytopenia
#18
Rachel McAndrew, Lindsay Thelin, Ammar Ahmed
No abstract text is available yet for this article.
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654466/detection-of-beta-human-papillomavirus-in-a-child-with-polyomavirus-associated-trichodysplasia-spinulosa
#19
Pooja Kadam, Teddy Pan, Rachelle Gates, Jessica Rivetz, Peter Rady, Stephen Tyring, John A Carlson
Viral associated trichodysplasia spinulosa (VATS) is a rare cutaneous eruption characterized by folliculocentric papules, keratin spicules, and alopecia associated with trichodysplasia spinulosa-associated polyomavirus (TSPyV) infection. We report a case of a 6-year-old male child who presented with a generalized papular eruption during chemotherapy for acute lymphoblastic leukemia. The papules were tested for human papillomavirus (HPV) DNA by nested polymerase chain reaction (PCR) and TSPyV using PCR and gene sequencing studies...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654465/high-velocity-paint-gun-injuries
#20
Wendi E Wohltmann, Joshua A Wisell, Celina M C Lafrades, Daniel M Cramer, Bruce D Ragsdale
Cutaneous injuries due to industrial high-pressure paint guns are well-documented in the literature; however, the histologic characteristics are uncommonly described, and facial involvement has not been previously reported. Histopathologic features of paint gun injuries vary depending on the time since injection and type of material. Early lesions display an acute neutrophilic infiltrate, edema, and thrombosis, with varying degrees of skin, fat, and muscle necrosis. More developed lesions (120-192 hours after injury) have prominent histiocytes and fibrosis around necrotic foci, possibly with the pitfall of muscle regenerative giant cells that could be mistaken for sarcoma...
June 20, 2017: American Journal of Dermatopathology
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