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American Journal of Dermatopathology

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https://www.readbyqxmd.com/read/28195843/lipophagic-panniculitis-of-childhood-a-case-report-and-comprehensive-review-of-the-literature
#1
Jack Levy, Mark E Burnett, Cynthia M Magro
Lipophagic panniculitis of childhood is a rare condition notable clinically for an inflammatory panniculitis followed by the development of permanent lipoatrophy. In this regard, the term lipoatrophic panniculitis has been used synonymously with lipophagic panniculitis. Additional designations include lipophagic lipoatrophic panniculitis and annular lipoatrophic panniculitis of the ankles. Although lipophagic panniculitis has been associated with a number of autoimmune phenomena, a paucity of reports and limited pathological analyses to date renders this disease an elusive one whose pathogenesis is not yet established...
February 10, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28169868/commentary-to-the-article-a-rare-collision-in-dermatopathology-basal-cell-carcinoma-and-atypical-fibroxanthoma
#2
Rubina Alves, Juan Ocaña, Esmeralda Vale, Isabel Viana
No abstract text is available yet for this article.
February 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28169867/germinotropic-onychocytic-matricoma-a-new-histopathologic-subtype-of-onychocytic-matricoma-in-the-light-of-the-microanatomy-of-the-normal-nail-unit-with-special-reference-to-nail-mesenchyme
#3
Christophe Perrin
Onychocytic matricoma (OCM) is a benign tumor of adnexal keratinocytes in which there is complete cytodifferentiation toward the germinative cells of the nail matrix, the keratogenous zone cells, and cells of the nail plate. Several microscopic variants of OCM were initially recognized; acanthotic type, acanthotic and papillomatous type, keratogenous type, and melanocytic as slight proliferation of dendritic melanocytes within the basaloid cells. This study reports an additional histopathologic variant of OCM...
February 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28169866/low-grade-neuroendocrine-carcinoma-of-the-skin-primary-cutaneous-carcinoid-tumor-as-a-distinctive-entity-of-cutaneous-neuroendocrine-tumors-a-clinicopathologic-study-of-3-cases-with-literature-review
#4
Keisuke Goto, Takashi Anan, Takashi Nakatsuka, Yo Kaku, Takaki Sakurai, Takaya Fukumoto, Tetsunori Kimura, Arihiro Shibata
There is scarcity of information on primary cutaneous low-grade neoplasms commonly known as carcinoid tumors, owing to their rarity. The authors present 3 cases that were named "low-grade neuroendocrine carcinoma of the skin" (LGNECS). These occurred in the dermis and subcutis of the anterior chest or the inguinal region in the elderly. Histologically, the tumors showed infiltrating proliferation of nests of various sizes, with low-grade neuroendocrine cytologic features but without mucin production. All cases exhibited varying degrees of intraductal tumor components...
February 2, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28178008/processing-adipose-rich-mohs-samples-a-comparative-study-of-effectiveness-of-pretreatment-with-liquid-nitrogen-versus-flash-freezing-spray
#5
Jeave Reserva, Zachary Kozel, Cindy Krol, Jodi Speiser, William Adams, Rebecca Tung
Processing of adipose-rich Mohs micrographic surgery (MMS) specimens poses challenges that may preclude complete margin evaluation. In this setting, the value of additional freezing methods using various cooling agents has not been previously investigated. The aim of this study is to compare the frozen section quality of high-adipose Mohs specimens processed without additional cooling treatments versus those pretreated with 1,1,1,2-tetrafluoroethane (TFE) or liquid nitrogen (LN2). A set of 3 sections were each taken from 24 adipose-rich Mohs micrographic surgery specimens...
January 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28178007/role-of-skin-biopsies-in-the-diagnosis-of-hemophagocytic-lymphohistiocytosis
#6
Aileen Santos-Arroyo, Julián Barrera-Llaurador, Julio E Sánchez, Rafael Martín-García, Jorge L Sánchez
This is a report of a 15-year-old female who presented with a skin eruption and clinical features consistent with severe sepsis and septic shock. A diagnosis of acquired hemophagocytic lymphohistiocytosis (HLH) was made and confirmed by bone marrow analysis. Skin biopsy showed hemophagocytosis and CD163-positive staining of macrophages. We briefly review the clinical, histologic, and laboratory findings of hemophagocytic lymphohistiocytosis in addition to the potential role of skin biopsies in this condition...
January 26, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28178009/isolated-ectopic-cutaneous-atypical-meningioma-of-the-scalp-another-mimicker-of-primary-adnexal-tumor
#7
Jonathan Konopinski, Victor G Prieto, Doina Ivan, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Carlos A Torres-Cabala, Gregory N Fuller, Phyu P Aung
Cutaneous meningiomas are rare tumors most commonly located in the skin and soft tissue of the scalp. They may be congenital (type I), acquired and derived from ectopic arachnoid tissue in the skin (type II), or arise through direct extension from an intracranial meningioma (type III). Despite their well-established documentation in the literature, they may escape recognition when classic features are not present. Herein, we present a case of a cutaneous atypical meningioma (≥4 mitotic figures/10 High Power Fields (HPF)) on the posterior scalp of a 31-year-old man with histologic features mimicking a malignant adnexal tumor...
January 25, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28121638/epidermolytic-ichthyosis-sine-epidermolysis
#8
Marina Eskin-Schwartz, Marianna Drozhdina, Ofer Sarig, Andrea Gat, Tomer Jackman, Ofer Isakov, Noam Shomron, Liat Samuelov, Natalia Malchin, Alon Peled, Dan Vodo, Alain Hovnanian, Thomas Ruzicka, Sergei Koshkin, Robert M Harmon, Jennifer L Koetsier, Kathleen J Green, Amy S Paller, Eli Sprecher
Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal epidermal keratins. Because of the variable clinical features and severity of the disease, histopathology is often required to correctly direct the molecular analysis. EI is characterized by hyperkeratosis and vacuolar degeneration of the upper epidermis, also known as epidermolytic hyperkeratosis, hence the name of the disease. In the current report, the authors describe members of 2 families presenting with clinical features consistent with EI...
January 17, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28098597/sporadic-trichoblastomas-and-those-occurring-in-the-setting-of-multiple-familial-trichoepithelioma-brooke-spiegler-syndrome-show-no-bap1-loss
#9
Liubov Kyrpychova, Denisa Kacerovska, Michal Michal, Dmitry V Kazakov
No abstract text is available yet for this article.
January 12, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28098596/erythema-nodosum-leprosum-like-lesions-are-a-histopathologic-pattern-in-whipple-s-disease-and-a-sign-of-the-immune-reconstitution-inflammatory-syndrome-a-case-series-and-review-of-the-literature
#10
Julia Liersch, Agnès Carlotti, Anne Theunis, Alexandra Leonard, Mary Barrett, John Andrew Carlson, Jörg Schaller
Inflammatory and subcutaneous nodules can arise in treated and untreated cases of Whipple disease (WD). The inflammatory immune reconstitution syndrome describes paradoxical clinical inflammatory worsening of a preexisting condition because of a return of immune function. Clinicopathologic examination of 4 patients with WD who presented with erythema nodosum leprosum (ENL)-like lesions and the findings of a systematic review of this phenomenon revealed that ENL-like lesions occurred in predominantly middle-aged male patients who suffered from WD, mostly on the legs...
January 10, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28067672/evolution-of-fibroblastic-connective-tissue-nevus-in-an-infant
#11
Michael C Lynch, Thomas D Samson, Andrea L Zaenglein, Catherine G Chung
Fibroblastic connective tissue nevus (FCTN) is a rare and recently described neoplasm of fibroblastic/myofibroblastic lineage. We report a case of a 1-month-old healthy male infant who presented with a dermal plaque on the upper chest since birth. A punch biopsy demonstrated a dermal spindle-cell neoplasm with variable smooth muscle actin positivity and negative staining for CD34, consistent with myofibroma. Over the course of the next year, the remaining lesional tissue exhibited clinical softening and a surgical excisional specimen revealed histologic findings distinct from the original biopsy...
January 5, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28157131/zosteriform-mycosis-fungoides-a-new-clinical-presentation-with-a-dermatomal-distribution
#12
Kerri E Rieger, Jinah Kim, Youn H Kim
Classic mycosis fungoides (MF) presents with patches and plaques on the trunk and proximal extremities. However, numerous clinicopathologic variants have been described, making diagnosis challenging. Here, the authors report a 21-year-old woman with immunophenotypically and molecularly confirmed MF occurring in a dermatomal distribution. Awareness of this and other rare variants of MF is critical to avoid misdiagnosis.
December 29, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033156/tubulopapillary-cystic-adenoma-with-apocrine-differentiation-a-unifying-concept-for-syringocystadenoma-papilliferum-apocrine-gland-cyst-and-tubular-papillary-adenoma
#13
Shin-Ichi Ansai, Takashi Anan, Takaya Fukumoto, Hidehisa Saeki
Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with apocrine differentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033155/lymph-node-involvement-by-a-clear-cell-nodular-hidradenoma-like-tumor-of-uncertain-malignant-potential
#14
Brandon Au, Konstantinos G Sidiropoulos, Danny Ghazarian, Michael Sidiropoulos
No abstract text is available yet for this article.
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#15
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28027081/altered-expression-of-toll-like-receptors-in-human-oral-epithelium-in-oral-lichenoid-reactions
#16
Abdelhakim Salem, Rabeia Mustafa, Dyah Listyarifah, Ahmed Al-Samadi, Goncalo Barreto, Dan Nordström, Kari K Eklund
Oral lichenoid reactions (OLRs) are chronic inflammatory lesions induced by contact with allergens. Toll-like receptors (TLRs) are members of pattern-recognition receptor superfamily. Once activated, TLRs induce production of cytokines and chemokines, thus leading to inflammatory reaction in host tissue. In the present study, we aimed to investigate the potential role of TLRs in the initiation and perpetuation of OLRs, in which TLRs induce innate immune responses mounted against allergens. TLRs, 1 through 10, were mapped in tissue samples obtained from healthy donors and OLR patients using real-time quantitative reverse transcription polymerase chain reaction, immunostaining, and image analyses...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28027080/carcinoid-like-labyrinthine-pattern-in-sebaceous-neoplasms-represents-a-sebaceous-mantle-phenotype-immunohistochemical-analysis-of-aberrant-vimentin-expression-and-cytokeratin-20-positive-merkel-cell-distribution
#17
Keisuke Goto, Takashi Anan, Takaya Fukumoto, Tetsunori Kimura, Noriyuki Misago
This study investigated the nature of carcinoid-like, labyrinthine, rippled, and conventional cell arrangements in sebaceous neoplasms, focusing on vimentin expression and Merkel cell distribution in sebaceous neoplasms relative to these findings in normal sebaceous units and other sebaceous conditions. Immunohistochemistry for vimentin and cytokeratin 20 (CK20) was evaluated in carcinoid-like (n = 2), labyrinthine (n = 4), rippled (n = 3), and conventional (n = 6) sebaceomas; sebaceous mantle hyperplasia (n = 1); steatocystomas (n = 5); fibrofolliculomas (n = 4); sebaceous mantleoma (n = 1); sebaceous gland hyperplasias (n = 4); sebaceous adenomas (n = 4); and sebaceous carcinomas (n = 4) as well as normal skin tissue...
December 23, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28030367/activation-of-pkc%C3%AE-and-pi3k-kinases-in-hypertrophic-and-nodular-port-wine-stain-lesions
#18
Rong Yin, Lin Gao, Wenbin Tan, Wei Guo, Tao Zhao, Jhon Stuart Nelson, Gang Wang
Port wine stain (PWS) is a congenital, progressive vascular malformation. Many patients with PWS develop hypertrophy and discrete nodularity during their adult life, but the mechanism(s) remain incompletely understood. In this study, we attempted to investigate activation status of PKCα, PI3K, PDPK1 and PLC-γ and protein levels of PP2A and DAG to explore their potential roles in the formation of hypertrophic and nodular PWS lesions. We found phosphorylated levels of PKCα, PI3K, PDPK1, and PLC-γ and protein levels of PP2A and DAG showed moderate increases in the endothelial cells of hypertrophic PWS as compared to the adjacent normal skin...
December 20, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28002100/revisiting-pax-8-s-labeling-of-merkel-cell-carcinoma
#19
David P Wang, Ryan A Stevens, Joshua A Wisell
No abstract text is available yet for this article.
December 19, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28002099/achille-civatte-a-master-of-the-microscope
#20
Jannett Nguyen, Dorota Z Korta
Achille Civatte (1877-1956) was one of the most highly regarded dermatologists of the 20th century. We provide a succinct account of Civatte's academic life and contributions to the field of dermatopathology, in addition to briefly discussing his son, Jean Civatte, who himself became a highly regarded dermatologist.
December 19, 2016: American Journal of Dermatopathology
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