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Journal of Clinical Gastroenterology

Joshua A Sloan, Ramzi Mulki, Naemat Sandhu, Solomon Samuel, Philip O Katz
GOALS: The aim of our study was to characterize jackhammer esophagus symptoms and their relationship with the distal contractile integral (DCI) and bolus transit. BACKGROUND: Jackhammer esophagus is defined by the Chicago Classification version 3.0. This diagnosis is relatively new, with the most current definition being established in 2014. The forerunners of this diagnosis, nutcracker (or hypercontractile) esophagus, have been associated with noncardiac chest pain (NCCP)...
March 7, 2018: Journal of Clinical Gastroenterology
Tyler Hyungtaek Rim, JaeSang Ko, Sung Soo Kim, Jin Sook Yoon
GOALS: This study aimed to evaluate the association between gastroesophageal reflux disease (GERD) and development of lacrimal drainage obstruction (LDO). BACKGROUND: It has been hypothesized that GERD may contribute toward the development of LDO. STUDY: This was a retrospective study of Koreans aged 40 to 79 years registered in the Korean National Health Screening Cohort from 2002 to 2013. Incident cases of LDO were identified according to the Korean Classification of Disease...
March 7, 2018: Journal of Clinical Gastroenterology
Christopher D Mills, Chere McCamley, Michael P Swan
GOALS: To determine the effect of carbon dioxide insufflation on the most important outcome measure of colonoscopic quality: adenoma detection rate (ADR). BACKGROUND: Bowel cancer is the second most common cause of cancer deaths in males and females in Australia. Carbon dioxide has in recent times become the insufflation methodology of choice for screening colonoscopy for bowel cancer, as this has been shown to have significant advantages when compared with traditional air insufflation...
March 7, 2018: Journal of Clinical Gastroenterology
Oscar V Hernández Mondragón, Juan M Velez Resendiz, Rodolfo R Ruiz
BACKGROUND AND AIMS: Pancreatic solid masses (PSM) are difficult to assess; endoscopic ultrasound with fine-needle aspiration (FNA) enables tissue acquisition, but has high false-negative rates. Quantitative elastography (QE) predicts diagnosis on the basis of the strain ratio (SR). We aimed to compare both methods to evaluate PSM. MATERIALS AND METHODS: This prospective study, carried out between January and December 2016, included suspected PSM cases; those with advanced disease and cystic components were excluded...
March 7, 2018: Journal of Clinical Gastroenterology
Mohamed I Radwan, Mohamed H Emara, Ibrahim M Ibrahim, Mahmoud E Moursy
BACKGROUND AND STUDY AIM: Removal of large common bile duct (CBD) stones is one of the challenges faced during endoscopic retrograde cholangiopancreatography, and it seems more difficult in cirrhotic patients because of suspected higher rates of adverse events, especially bleeding diathesis. This study aimed at comparing the success rate and complications between mechanical lithotripsy (ML) and large balloon dilation (LBD) after endoscopic sphincterotomy in patients with liver cirrhosis...
March 7, 2018: Journal of Clinical Gastroenterology
Amy Tyberg, Isaac Raijman, Ali Siddiqui, Urban Arnelo, Douglas G Adler, Ming-Ming Xu, Najib Nassani, Divyesh V Sejpal, Prashant Kedia, Yun Nah Lee, Frank G Gress, Sammy Ho, Monica Gaidhane, Michel Kahaleh
INTRODUCTION: In patients with pancreaticobiliary lesions anticipating surgical resection, digital pancreaticocholangioscopy can be used to identify the extent of disease. This presurgical"mapping" could change the surgical plan and optimize patient care. MATERIALS AND METHODS: Patients with pancreaticobiliary lesions anticipating surgery who underwent endoscopic retrograde cholangiopancreatography with digital pancreaticocholangioscopy from 9 international centers were included...
March 6, 2018: Journal of Clinical Gastroenterology
Andres J Yarur, Anjali Jain, Maria A Quintero, Frank Czul, Amar R Deshpande, David H Kerman, Maria T Abreu
BACKGROUND: A significant number of patients receiving therapy with antitumor necrosis factor (TNF) agents for Crohn's disease experience primary or secondary nonresponse. The aim of this study was to assess whether patients with nonresponse to anti-TNF agents have increased expression of alternative cytokine pathways. METHODS: We designed a prospective, cross-sectional study that included patients with Crohn's disease receiving anti-TNF undergoing colonoscopy with adequate serum trough drug levels (≥8 µg/mL) and without anti-drug antibodies...
March 6, 2018: Journal of Clinical Gastroenterology
Songxu Peng, Zhihua Wan, Tingting Liu, Huiping Zhu, Yukai Du
GOALS: To identify the potential risk factors of hepatitis B virus (HBV) intrauterine transmission and predict the incidence of HBV intrauterine transmission among hepatitis B surface antigen-positive pregnant women with diverse viral load. BACKGROUND: The intrauterine transmission of HBV significantly contributes to the persistence of a high number of patients infected with HBV. However, its risk factors remain unclear. MATERIALS AND METHODS: A prospective study was performed on hepatitis B surface antigen-positive pregnant women who delivered from June 2012 to December 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China...
March 6, 2018: Journal of Clinical Gastroenterology
François Cossais, Sebastian Leuschner, Martina Barrenschee, Christina Lange, Michael Ebsen, Ilka Vogel, Martina Böttner, Thilo Wedel
BACKGROUND: Diverticular disease (DD) is a common gastrointestinal inflammatory disorder associated with an enteric neuropathy. Although enteric glial cells (EGCs) are essential regulators of intestinal inflammation and motility functions, their contribution to the pathophysiology of DD remains unclear. Therefore, we analyzed the expression of specific EGC markers in patients with DD. MATERIALS AND METHODS: Expression of the glial markers S100β, GFAP, Sox10, and Connexin 43 was analyzed by real-time quantitative PCR in colonic specimens of patients with DD and in that of controls...
March 6, 2018: Journal of Clinical Gastroenterology
Ziad Bakouny, Fares Yared, Elie El Rassy, Rita Jabbour, Rachel Hallit, Nathalie Khoury, Khalil Honein, Joseph Bou Jaoude
INTRODUCTION: There is a lack of studies on the optimal anti-tumor necrosis factor (anti-TNF) agent for postoperative prophylaxis of Crohn's disease (CD) recurrence. Therefore, we conducted a network meta-analysis (NMA) of prospective trials to compare the efficacy of anti-TNF agents in the prevention of postoperative endoscopic and clinical recurrence of CD following ileocolonic resection. METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and recent American gastroenterology association (AGA) meeting abstracts through August 2017...
March 6, 2018: Journal of Clinical Gastroenterology
Georgios Tziatzios, Paraskevas Gkolfakis, Konstantinos Triantafyllou
No abstract text is available yet for this article.
March 6, 2018: Journal of Clinical Gastroenterology
Shashank Sarvepalli, Sushil K Garg, Siri S Sarvepalli, Chimaobi Anugwom, Vaibhav Wadhwa, Prashanthi N Thota, Madhusudhan R Sanaka
INTRODUCTION: Although gastric cancer (GC) rates have been declining in the United States, it continues to be a major cause of morbidity. This study examined trends in hospital admissions, in-hospital mortality, length of stay (LOS), and inpatient costs related to GC. In addition, various factors associated with in-hospital mortality, LOS, and inpatient costs were examined. METHODS: National inpatient sample-the largest publicly available all-payer inpatient care database-was interrogated to obtain information about various demographic and hospital-related factors (including those mentioned above) in patients who were primarily admitted for GC between the years 1998 to 2013...
March 6, 2018: Journal of Clinical Gastroenterology
Jose Melendez-Rosado, Juan E Corral, Sheetal Patel, Raul J Badillo, Dawn Francis
GOALS: The goal of this study is to examine the causes, type of adverse events (AE), and effects of elective intubation in outcomes associated with esophageal food impaction (EFI). BACKGROUND: EFI is a gastrointestinal emergency requiring immediate medical attention. STUDY: Retrospective review of all EFI cases presenting at 3 large tertiary centers from October 1, 2011 to October 31, 2014 and all cases registered in the Clinical Outcome Research Initiative (CORI) database from January 1, 2000 to December 31, 2012...
March 6, 2018: Journal of Clinical Gastroenterology
Hugo Perazzo, Isabela Benseñor, José Geraldo Mill, Antônio G Pacheco, Maria de Jesus Mendes da Fonseca, Rosane Härter Griep, Paulo Lotufo, Dora Chor
GOALS: To develop a noninvasive algorithm for diagnosis of liver steatosis and to compare its diagnostic value with available predictive models. BACKGROUND: Liver steatosis represents the most frequent liver disease worldwide. STUDY: This cross-sectional study analyzed data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Patients were randomly divided into training (n=6571) and validation (n=3286) cohort. Abdominal ultrasound (US), used to grade steatosis, and overnight fasting blood tests were performed at the same day...
March 2, 2018: Journal of Clinical Gastroenterology
Felix W Leung, Malcolm Koo, Sergio Cadoni, Premysl Falt, Yu-Hsi Hsieh, Arnaldo Amato, Matteo Erriu, Petr Fojtik, Paolo Gallittu, Chi-Tan Hu, Joseph W Leung, Mauro Liggi, Silvia Paggi, Franco Radaelli, Emanuele Rondonotti, Vit Smajstrla, Chih-Wei Tseng, Ondrej Urban
GOALS: To test the hypothesis that water exchange (WE) significantly increases adenoma detection rates (ADR) compared with water immersion (WI). BACKGROUND: Low ADR was linked to increased risk for interval colorectal cancers and related deaths. Two recent randomized controlled trials of head-to-head comparison of WE, WI, and traditional air insufflation (AI) each showed that WE achieved significantly higher ADR than AI, but not WI. The data were pooled from these 2 studies to test the above hypothesis...
March 2, 2018: Journal of Clinical Gastroenterology
Pilvi Laurikka, Katri Lindfors, Mikko Oittinen, Heini Huhtala, Teea Salmi, Marja-Leena Lähdeaho, Tuire Ilus, Markku Mäki, Katri Kaukinen, Kalle Kurppa
GOALS: The aim of this study was to investigate the role of dietary factors, distinct small-bowel mucosal immune cell types, and epithelial integrity in the perpetuation of gastrointestinal symptoms in treated celiac disease patients. BACKGROUND: For unexplained reasons, many celiac disease patients suffer from persistent symptoms, despite a strict gluten-free diet (GFD) and recovered intestinal mucosa. STUDY: We compared clinical and serological data and mucosal recovery in 22 asymptomatic and 25 symptomatic celiac patients on a long-term GFD...
March 2, 2018: Journal of Clinical Gastroenterology
Anupong Tangaroonsanti, Augustine S Lee, Marcelo F Vela, Michael D Crowell, David Erasmus, Cesar Keller, Jorge Mallea, Francisco Alvarez, Cristina Almansa, Kenneth R DeVault, Lesley A Houghton
GOALS: To assess the effect of unilateral versus bilateral lung transplantation (LTx) on esophageal motility and gastroesophageal reflux, and the association with the development of obstructive chronic lung allograft dysfunction (o-CLAD). BACKGROUND: We have shown that esophagogastric junction outflow obstruction, incomplete bolus transit, and proximal reflux are all independent risk factors for the development of chronic allograft failure. However, it remains unclear whether these factors are influenced by the type of surgery and how this relates to allograft failure...
March 2, 2018: Journal of Clinical Gastroenterology
Gabriela Longarini, Pablo Richly, M de la Paz Temprano, Ana F Costa, Horacio Vázquez, María L Moreno, Sonia Niveloni, Pablo López, Edgardo Smecuol, Roberto Mazure, Andrea González, Eduardo Mauriño, Julio C Bai
AIMS: Our objectives were to: (1) determine whether celiac disease (CD) patients have cognitive impairment at diagnosis; and (2) compare their cognitive performance with nonceliac subjects who have similar chronic symptoms and healthy controls. MATERIALS AND METHODS: Fifty adults (age range: 18 to 50 y) with symptoms and signs compatible with CD were enrolled in a prospective cohort irrespective of the final diagnosis. At baseline, all individuals underwent cognitive functional and psychological evaluation...
March 1, 2018: Journal of Clinical Gastroenterology
Kengo Onochi, Hisashi Shiga, So Takahashi, Noboru Watanabe, Sho Fukuda, Mitsuaki Ishioka, Shigeto Koizumi, Tamotsu Matsuhasi, Mario Jin, Katsunori Iijima
GOALS: To investigate retrospectively the risk factors for synchronous and metachronous cancers in the upper gastrointestinal tract in patients with superficial esophageal squamous cell carcinoma (ESCC). BACKGROUND: In patients who have received endoscopic resection (ER) for ESCC, synchronous and metachronous cancers are frequently detected not only in the esophagus but also in the head and neck area and the stomach. STUDY: A total of 285 patients who received ER for superficial ESCC were enrolled in this analysis...
March 1, 2018: Journal of Clinical Gastroenterology
Hyo-Joon Yang, Min-Jung Kwon, Yoosoo Chang, Seul-Ki Song, Kwang-Sung Ahn, Han-Na Kim, Yeojun Yun, Hyung-Lae Kim, Dong Il Park
GOALS AND BACKGROUND: This study aimed to compare differences in the fecal microbiota according to the risk of advanced colorectal neoplasia (ACN) based on a risk-score model in a large Korean cohort. STUDY: Stool samples were collected from 1122 health screening recipients: 404 enrolled in the average risk (AR) group, 514 in the moderate risk (MR) group, and 204 in the high risk (HR) group, in accordance with their risk of ACN. The fecal microbiota was characterized using pyrosequencing of the V3-V4 region of the 16S rRNA genes...
February 9, 2018: Journal of Clinical Gastroenterology
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