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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/27898520/mesalazine-in-the-treatment-of-symptomatic-uncomplicated-diverticular-disease
#1
Cong Dai, Min Jiang, Ming-Jun Sun
No abstract text is available yet for this article.
November 28, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27898519/optimizing-the-outcomes-associated-with-spontaneous-bacterial-peritonitis
#2
Rinjal Brahmbhatt, Elliot B Tapper
No abstract text is available yet for this article.
November 28, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27898518/tyrosinemia-presenting-with-multiple-hepatic-lesions-and-splenomegaly
#3
Anahita Sanaei Dashti, Seyedeh Sedigheh Hamzavi
No abstract text is available yet for this article.
November 28, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875360/outcomes-after-conservative-endoscopic-and-surgical-treatment-of-groove-pancreatitis-a-systematic-review
#4
Liesbeth M Kager, Selma J Lekkerkerker, Marianna Arvanitakis, Myriam Delhaye, Paul Fockens, Marja A Boermeester, Jeanin E van Hooft, Marc G Besselink
BACKGROUND: Groove pancreatitis (GP) is a focal form of chronic pancreatitis affecting the paraduodenal groove area, for which consensus on diagnosis and management is lacking. GOALS: We performed a systematic review of the literature to determine patient characteristics and imaging features of GP and to evaluate clinical outcomes after treatment. RESULTS: Eight studies were included reporting on 335 GP patients with a median age of 47 years (range, 34 to 64 y), with 90% male, 87% smokers, and 87% alcohol consumption, and 47 months (range, 15 to 122 mo) of follow-up...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875359/symptom-index-or-symptom-association-probability-a-closer-look-at-symptom-association-in-suspected-gerd-patients
#5
Mustafa Abdul-Hussein, Crystal Zhang, Donald Castell
BACKGROUND: Symptom index (SI) and symptom association probability (SAP) are popular methods used to measure symptom association in patients with gastroesophageal reflux disease (GERD). AIM: To investigate whether these 2 methods yield similar results in analysis of both typical and atypical GERD symptoms. MATERIALS AND METHODS: Combined impedance-pH reflux studies of 1471 patients tested for possible GERD symptoms from January 2010 to May 2015 were reviewed...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875358/-mesalazine-in-the-treatment-of-symptomatic-uncomplicated-diverticular-disease-reply
#6
Antonio Tursi
No abstract text is available yet for this article.
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875357/optimal-timing-of-endoscopic-retrograde-cholangiopancreatography-in-acute-cholangitis
#7
Linda A Hou, Loren Laine, Nima Motamedi, Ara Sahakian, Christianne Lane, James Buxbaum
OBJECTIVES: Acute cholangitis mandates resuscitation, antibiotic therapy, and biliary decompression. Our aim was to define the optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) for patients with acute cholangitis. METHODS: Clinical data on all cases of cholangitis managed by ERCP were prospectively collected from September 2010 to July 2013. The clinical impact of the time to ERCP, defined as the time from presentation in the emergency department to the commencement of the ERCP, was determined...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875356/corticosteroids-and-thiopurines-but-not-tumor-necrosis-factor-antagonists-are-associated-with-cytomegalovirus-reactivation-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#8
Tushar Shukla, Siddharth Singh, Parul Tandon, Jeffrey D McCurdy
BACKGROUND: The association between cytomegalovirus (CMV) reactivation and individual immunosuppressive agents in inflammatory bowel disease (IBD) has not been clearly defined. Therefore, we performed a systematic review and meta-analysis to assess this association. METHODS: Multiple electronic databases were searched systematically through July 2015 for observational studies reporting CMV reactivation (based on serum-based or tissue-based tests) in IBD patients stratified by medication exposure...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875355/novel-mutations-in-epcam-cause-congenital-tufting-enteropathy
#9
Wenjuan Tang, Taosheng Huang, Zhongyao Xu, Ying Huang
BACKGROUND AND AIMS: Congenital tufting enteropathy (CTE) is a rare autosomal recessive form of intractable diarrhea of infancy. Patients develop chronic diarrhea within days after birth, leading to severe malabsorption and significant mortality. CTE is characterized by subtotal villous atrophy with crypt hyperplasia. Typical features include abnormal villi in the intestinal epithelium and disorganization of surface enterocytes with focal crowding, resembling tufts. The pathogenesis of CTE remains poorly understood...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875354/antiviral-treatment-for-colonic-cytomegalovirus-infection-in-ulcerative-colitis-patients-significantly-improved-their-surgery-free-survival
#10
Yinghong Wang, Pankaj Aggarwal, Xiuli Liu, Haiyan Lu, Lei Lian, Xianrui Wu, Shibin Guo, Nitin Aggarwal, Bret Lashner, Bo Shen
BACKGROUND: The frequency of cytomegalovirus (CMV) colitis in steroid-refractory inflammatory bowel disease has been reported to range from 15.8% to 34.0%. Infected patients are more likely to become hospitalized, have longer lengths of stay, and higher mortality rates. Current data are limited to small scale studies and showed conflicting result regarding the role of antiviral therapy. AIMS: (1) To investigate the role of antiviral treatment in ulcerative colitis (UC) patients with CMV infection...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875353/cannabinoid-receptor-2-functional-variant-contributes-to-the-risk-for-pediatric-inflammatory-bowel-disease
#11
Caterina Strisciuglio, Giulia Bellini, Erasmo Miele, Massimo Martinelli, Sabrina Cenni, Chiara Tortora, Carlo Tolone, Emanuele Miraglia Del Giudice, Francesca Rossi
GOALS: We conducted a case-control association analysis to establish the role of a common CB2 functional variant, Q63R, in the susceptibility to inflammatory bowel disease (IBD). BACKGROUND: Endocannabinoids may limit intestinal inflammation through cannabinoid receptor 1 and/or 2 (CB1, CB2). STUDY: We genotyped 217 pediatric IBD patients [112 Crohn's disease (CD), 105 ulcerative colitis (UC)] and 600 controls for the CB2-Q63R variant by Taqman assay...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27875352/does-incorporating-change-in-apri-or-fib-4-indices-over-time-improve-the-accuracy-of-a-single-index-for-identifying-liver-fibrosis-in-persons-with-chronic-hepatitis-c-virus-infection
#12
Prabhu P Gounder, Celia Haering, Dana J T Bruden, Lisa Townshend-Bulson, Brenna C Simons, Philip R Spradling, Brian J McMahon
BACKGROUND: The aspartate aminotransferase-to-platelet ratio index (APRI) and a fibrosis index calculated using platelets (FIB-4) have been proposed as noninvasive markers of liver fibrosis. GOALS: To determine APRI/FIB-4 accuracy for predicting histologic liver fibrosis and evaluate whether incorporating change in index improves test accuracy in hepatitis C virus (HCV)-infected Alaska Native persons. STUDY: Using liver histology as the gold standard, we determined the test characteristics of APRI to predict Metavir ≥F2 fibrosis and FIB-4 to predict Metavir ≥F3 fibrosis...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27870642/hepatocellular-carcinoma-surveillance-among-patients-with-cirrhosis-in-a-population-based-integrated-health-care-delivery-system
#13
Amit G Singal, Jasmin Tiro, Xilong Li, Beverley Adams-Huet, Jessica Chubak
PURPOSE: Fewer than 1 in 5 patients with cirrhosis receive hepatocellular carcinoma (HCC) surveillance; however, most studies were performed in select patient populations, which may not be informative of practice patterns in population-based community practices. Further, few reported guideline-concordant consistent surveillance rates. GOALS: Characterize guideline-concordant HCC surveillance rates and patient-level factors associated with surveillance among a population-based cohort of patients with cirrhosis...
November 18, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27824641/permanent-indwelling-transmural-stents-for-endoscopic-treatment-of-patients-with-disconnected-pancreatic-duct-syndrome-long-term-results
#14
Felix I Téllez-Ávila, Luis E Casasola-Sánchez, Miguel Á Ramírez-Luna, Ángela Saúl, Enrique Murcio-Pérez, Carlos Chan, Luis Uscanga, Gilberto Duarte-Medrano, Francisco Valdovinos-Andraca
INTRODUCTION: Disconnected pancreatic duct syndrome (DPDS) is defined as the complete disruption of the main pancreatic duct, the result are peripancreatic fluid collections or pancreatic leaks. The aim of this study was to report the results of derivative endoscopic treatment of DPDS in a long-term follow-up period. PATIENTS AND METHODS: We performed a retrospective analysis of prospectively collected data. Endoscopic treatment consisted of transmural drainage with 2 double pigtail plastic stents (7 F and 4 cm) deployed under endoscopic ultrasound guidance...
November 7, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27824640/esophagorespiratory-fistulas-survival-and-outcomes-of-treatment
#15
Charles J Lenz, Benjamin L Bick, David Katzka, Francis C Nichols, Zachary S Depew, Louis M Wong Kee Song, Todd H Baron, Navtej S Buttar, Fabien Maldonado, Felicity T Enders, William S Harmsen, Ross A Dierkhising, Mark D Topazian
GOAL: The purpose of this study was to characterize outcomes of esophagorespiratory fistulas (ERF) by etiology and initial treatment strategy. BACKGROUND: ERF is a morbid condition for which optimal treatment strategies and outcomes are still in evolution. STUDY: Medical records and images were reviewed for all patients diagnosed with ERF at Mayo Clinic in Rochester, MN, between September 1, 2001 and January 1, 2012. Fistulas were classified as malignant or benign...
November 7, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27824639/age-adapted-variation-in-screening-interval-of-fecal-immunochemical-test-may-improve-its-participation-and-colonoscopy-acceptance
#16
Min Seob Kwak, Jae Myung Cha, Jin Young Yoon, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee
GOALS: We determined appropriate intervals for administering the fecal immunochemical test (FIT) and performance outcomes in an Asian national colorectal cancer (CRC) screening program. BACKGROUND: The optimal interval for FIT in CRC screening is unclear, especially in Asian populations. STUDY: Between January 2009 and December 2015, 13,480 individuals aged 50 years or older with an initial negative FIT result underwent 2 rounds of FIT screening at intervals of 1 (annual group, 5333), 2 (biennial group, 7363), or 3 years (triennial group, 784)...
November 7, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27820223/adenoma-detection-is-increased-in-the-setting-of-melanosis-coli
#17
John W Blackett, Richard Rosenberg, Srihari Mahadev, Peter H R Green, Benjamin Lebwohl
GOALS: To compare the adenoma detection rate (ADR) during colonoscopy in patients with melanosis coli against matched controls without melanosis. BACKGROUND: Melanosis coli is a colonoscopic finding in which the colon wall appears darkly pigmented, most often due to extended laxative use, and is considered benign. The pigmentation spares adenomas, which should therefore be more readily detectable in melanosis coli. STUDY: We identified all patients with melanosis on colonoscopy at our institution over a 5-year period...
November 4, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27820222/celiac-disease-and-risk-of-henoch-schonlein-purpura-population-based-cohort-study
#18
Jonas F Ludvigsson, Simon Jarrick, Joseph A Murray, Louise Emilsson
BACKGROUND AND AIMS: A recent study found a 10-fold increased risk of celiac disease (CD) in individuals with Henoch-Schonlein purpura (HSP), but the confidence interval (CI) was wide. METHODS: The retrospective cohort study of all patients with CD in Sweden, diagnosed through small intestinal biopsy from 1969 to 2008 (n=29,077). Each individual with CD was matched to up to 5 controls (n=144,433). Data on study participants were linked to diagnostic codes for HSP in the National Patient Registry...
November 4, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27811629/the-role-of-duodenal-inflammation-in-functional-dyspepsia
#19
Marjorie M Walker, Nicholas J Talley
Functional dyspepsia (FD) is common and significantly impairs quality of life. Symptoms of FD are considered to originate from the gastroduodenal region, classified by the Rome criteria as disorders of brain-gut interaction without structural alteration. However, it is now apparent that FD is a number of syndromes, the epigastric pain syndrome (bothersome epigastric pain or epigastric burning) and the postprandial distress syndrome (with bothersome postprandial fullness or early satiation) and there are wide-ranging symptoms and severity...
November 2, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27811628/a-national-survey-of-the-prevalence-and-impact-of-cytomegalovirus-infection-among-hospitalized-patients-with-ulcerative-colitis
#20
Laurie B Grossberg, Ghideon Ezaz, Douglas Grunwald, Jonah Cohen, Kenneth R Falchuk, Joseph D Feuerstein
GOALS: To estimate the effect of cytomegalovirus (CMV) in patients with ulcerative colitis (UC), and compare these outcomes to patients with CMV without UC. BACKGROUND: The impact of CMV infection in UC is not well understood. STUDY: We analyzed records from the Nationwide Inpatient Sample (NIS) of patients with UC and CMV between 2006 and 2012. Differences in outcomes were determined between patients with UC and CMV and those with UC without CMV...
November 2, 2016: Journal of Clinical Gastroenterology
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