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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/28445236/risk-stratification-in-acute-variceal-bleeding-child-pugh-versus-model-for-end-stage-liver-disease
#1
Enric Reverter, Joan Genesca, Salvador Augustin, Juan G Abraldes
No abstract text is available yet for this article.
April 25, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28445235/recent-trends-in-the-epidemiology-of-hepatocellular-carcinoma-in-olmsted-county-minnesota-a-us-population-based-study
#2
Ju Dong Yang, Hager Ahmed Mohammed, William S Harmsen, Felicity Enders, Gregory J Gores, Lewis R Roberts
BACKGROUND/AIM: The epidemiology of hepatocellular carcinoma (HCC) has changed in the United States recently. The aim of this study is to evaluate the recent trends of HCC epidemiology in Olmsted County, MN. METHODS: Residents aged over 20 with newly diagnosed HCC were identified using the Rochester Epidemiology Project database. Clinical information was compared among patients diagnosed between 2000 and 2009 (era 1) and 2010 to 2014 (era 2). RESULTS: Over 1...
April 25, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28422774/squamous-cellular-carcinoma-antigen-serum-determination-as-a-biomarker-of-barrett-esophagus-and-esophageal-cancer-a-phase-iii-study
#3
Gemma Maddalo, Matteo Fassan, Romilda Cardin, Marika Piciocchi, Filippo Marafatto, Massimo Rugge, Giovanni Zaninotto, Caterina Pozzan, Carlo Castoro, Alberto Ruol, Alessandra Biasiolo, Fabio Farinati
GOAL: To evaluate the potential role of the determination of the immunocomplexed form of squamous cell carcinoma antigen [SCCA-immunoglobulin (Ig)M] for the screening of Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). BACKGROUND: The cost-effectiveness of surveillance in BE is still debated and the use of biomarkers in screening and surveillance still not recommended. No information is available regarding SCCA-IgM determination in BE. STUDY: SCCA-IgM levels were determined (enzyme-linked immunosorbent assay) in 231 patients prospectively recruited, 71 with BE, 53 with EAC, and 107 controls, including 42 blood donors and 65 patients with gastroesophageal reflux...
April 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28394777/prognostic-significance-of-hemodynamic-and-clinical-stages-in-the-prediction-of-hepatocellular-carcinoma-methodological-issues
#4
Siamak Sabour
No abstract text is available yet for this article.
April 7, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28383303/early-hospital-readmissions-and-mortality-in-patients-with-decompensated-cirrhosis-enrolled-in-a-large-national-health-insurance-administrative-database
#5
Steven J Scaglione, Leanne Metcalfe, Stephanie Kliethermes, Ivan Vasilyev, Rebecca Tsang, Allyce Caines, Shaham Mumtaz, Vik Goyal, Asra Khalid, David Shoham, Talar Markossian, Amy Luke, Howard Underwood, Scott J Cotler
BACKGROUND: Patients with decompensated cirrhosis have high rates of morbidity and mortality and frequently require hospital admission. Few studies have examined early readmission as an indicator of 90 day and overall mortality. Analysis of large databases is needed to evaluate the association between early readmission and mortality in decompensated cirrhosis. METHODS: We analyzed 5 years of private, employer-based, health insurance claims data associated with HealthCare Services Corporation on 13...
April 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28375866/reply-to-risk-stratification-in-acute-variceal-bleeding-child-pugh-versus-model-for-end-stage-liver-disease
#6
Brett E Fortune, Maria Ciarleglio, Yanhong Deng, Guadalupe Garcia-Tsao
No abstract text is available yet for this article.
April 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28375865/aggressive-hydration-for-the-prevention-of-post-ercp-pancreatitis-effective-when-combined-with-rectal-nsaids
#7
Xavier J N M Smeets, Joost P H Drenth, Erwin J M van Geenen
No abstract text is available yet for this article.
April 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28375864/risk-factors-for-asparaginase-associated-pancreatitis-a-systematic-review
#8
Judy-April Oparaji, Fateema Rose, Debra Okafor, Amari Howard, Rose L Turner, Abrahim I Orabi, Craig Byersdorfer, Qi Mi, Kim Ritchey, Mark E Lowe, Sohail Z Husain
GOALS: To evaluate potential risk factors for the development of asparaginase-associated pancreatitis (AAP), we performed a systematic review of the current literature from January 1946 through May 2015. BACKGROUND: Asparaginase, a primary treatment for the most common childhood cancer, acute lymphoblastic leukemia (ALL), is a well-described cause of pancreatitis. Further, pancreatitis is among the most burdensome and common complications of asparaginase treatment and represents a major reason for early-drug termination and inferior outcomes...
April 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28362682/genetic-determinants-of-circulating-lipoproteins-in-nonalcoholic-fatty-liver-disease
#9
Zhenghui G Jiang, Elliot B Tapper, Misung Kim, Margery A Connelly, Sarah A Krawczyk, Eric U Yee, Mark A Herman, Kenneth J Mukamal, Michelle Lai
BACKGROUND: Recent genome-wide association studies have identified 2 genetic polymorphisms in association with nonalcoholic fatty liver disease (NAFLD): patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), both of which appear to influence the production of very low density lipoprotein (VLDL). The impact of these genetic variations on lipoprotein metabolism in the setting of nonalcoholic steatohepatitis and liver fibrosis are not fully characterized...
March 30, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28323748/serum-aminotransferase-flares-in-pregnant-and-postpartum-women-with-current-or-prior-treatment-for-chronic-hepatitis-b
#10
Christine Y Chang, Natali Aziz, Mugilan Poongkunran, Asad Javaid, Huy N Trinh, Daryl T Lau, Mindie H Nguyen
BACKGROUND AND AIMS: Antiviral therapy is recommended for pregnant women with chronic hepatitis B (CHB) and hepatitis B virus (HBV) DNA>200,000 IU/mL, but there is less consensus on management of women who discontinue therapy in anticipation of pregnancy or who become pregnant while on therapy. The goal of this study was to describe flares in alanine aminotransferase (ALT) during pregnancy and postpartum in CHB women with current and/or prior treatment. METHODS: This was a multicenter, retrospective study of 67 pregnancies in 56 CHB women treated before and/or during pregnancy...
March 20, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28296656/severity-and-outcome-of-acute-on-chronic-liver-failure-is-dependent-on-the-etiology-of-acute-hepatic-insults-analysis-of-368-patients
#11
Shalimar, Saurabh Kedia, Soumya J Mahapatra, Baibaswata Nayak, Deepak Gunjan, Bhaskar Thakur, Subrat K Acharya
BACKGROUND: Acute-on-chronic liver failure (ACLF) may be precipitated by various hepatic insults. The present study evaluated the outcomes of ACLF with different acute insults. PATIENTS AND METHODS: A total of 368 ACLF patients were included. Data collected included etiologies of acute hepatic insult and underlying chronic liver disease, and organ failure. Model for end-stage liver disease (MELD), chronic liver failure consortium (CLIF)-C ACLF, and acute physiology and chronic health evaluation (APACHE) II scores were calculated...
March 14, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28291175/ppi-trial-for-eosinophilic-esophagitis-chaos-in-the-community
#12
Seth Lipka, Ambuj Kumar, Joel E Richter
INTRODUCTION: Despite consensus eosinophilic esophagitis (EoE) statement published in 2011 calling for a 2-month trial of protons pump inhibitor (PPI), the guidelines are not followed by many. We studied the practice patterns in our community and response to a PPI retrial in patients previously diagnosed with "idiopathic EoE." METHODS: All patients presenting to the senior author's practice with suspected EoE from 2011 to 2015. Two cohorts were studied: (1) patients diagnosed in the community as "idiopathic EoE"; (2) treatment naïve patients given a PPI trial at University of South Florida...
March 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28277375/potential-pitfalls-when-assessing-the-impact-of-cytomegalovirus-in-inflammatory-bowel-disease
#13
Jeffrey D McCurdy, David H Bruining, Edward V Loftus
No abstract text is available yet for this article.
March 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28277374/clinical-predictors-for-kras-codon-13-mutations-in-patients-with-colorectal-cancer
#14
Min S Kwak, Jae M Cha, Young H Cho, Sang H Kim, Jin Y Yoon, Jung W Jeon, Hyun P Shin, Kwang R Joo, Joung I Lee
GOALS: This study sought to clarify sex differences in KRAS mutations and clinical predictors of KRAS 13 codon mutations. BACKGROUND: Sex differences in KRAS mutations and predictors for KRAS codon 13 mutations in colorectal cancer (CRC) are unclear. STUDY: Between October 2007 and May 2016, 328 patients underwent surgery for CRCs that were analyzed for KRAS mutations at a referral university hospital. Sex differences in the rates and distributions of KRAS mutations, and factors predictive of overall KRAS and KRAS codon 13 mutations were analyzed...
March 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28272079/natural-history-and-treatment-outcomes-of-severe-autoimmune-hepatitis
#15
Nikhil Sonthalia, Pravin M Rathi, Samit S Jain, Ravindra G Surude, Ashok R Mohite, Sunil V Pawar, Qais Contractor
GOALS: The aim of this study was to analyze the natural history and treatment outcomes of autoimmune hepatitis (AIH) variants presenting with severe-AIH. BACKGROUND: Severe acute presentation is an uncommon manifestation of AIH, and it remains poorly characterized. MATERIALS AND METHODS: We included 101 patients with AIH from January 2011 to December 2015. Patients were classified as seropositive-AIH and seronegative-AIH. Patients with acute liver failure, acute-on-chronic liver failure, and severe acute hepatitis were defined as severe-AIH patients...
March 7, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28266939/resumption-of-warfarin-after-hospitalization-for-lower-gastrointestinal-bleeding-and-mortality-benefits
#16
Parita Patel, Neha Nigam, Neil Sengupta
GOALS: To evaluate whether resumption of warfarin after hospitalization for lower gastrointestinal bleeding (LGIB) is associated with improved 90-day and 6-month survival. BACKGROUND: LGIB is a common complication for patients on warfarin. There is limited data to guide clinicians on the optimal management of warfarin following hospitalization for LGIB. STUDY: We identified patients hospitalized with LGIB while on warfarin using a validated, machine-learning algorithm...
March 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28263238/evaluation-of-effects-of-radiofrequency-ablation-of-ex-vivo-liver-using-the-1-fr-wire-electrode
#17
Tarun Rustagi, Ferga C Gleeson, Barham K Abu Dayyeh, Mark D Topazian, Michael J Levy
BACKGROUND AND STUDY AIMS: Percutaneous and intraoperative radiofrequency ablation (RFA) has become a valued tool in the management of primary and secondary hepatic lesions. A recent FDA-approved endoscopic ultrasound (EUS)-guided RFA probe now offers promise to help manage such lesions. However, there are no data to determine the ideal power setting and duration of ablation needed to effectively treat hepatic masses. The aim of the study was to evaluate the macroscopic zone of hepatic injury for EUS-RFA using a variety of settings within a fresh porcine hepatic specimen...
March 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28157734/accuracy-of-consecutive-fecal-calprotectin-measurements-to-predict-relapse-in-inflammatory-bowel-disease-patients
#18
Cong Dai, Qin Cao, Min Jiang
No abstract text is available yet for this article.
February 2, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28267690/pathophysiology-and-therapeutic-options-for-fecal-incontinence
#19
Alexandra Guillaume, Ahmed E Salem, Patricia Garcia, Bani Chander Roland
Fecal incontinence (FI), defined as the involuntary loss of solid or liquid feces through the anus is a prevalent condition with significant effects on quality of life. FI can affect individuals of all ages and in many cases greatly impairs quality of life but, incontinent patients should not accept their debility as either inevitable or untreatable. The severity of incontinence can range from unintentional elimination of flatus to the complete evacuation of bowel contents. It is reported to affect up to 18% of the population, with a prevalence reaching as high as 50% in nursing home residents...
April 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28267052/probiotics-for-preventing-and-treating-small-intestinal-bacterial-overgrowth-a-meta-analysis-and-systematic-review-of-current-evidence
#20
Changqing Zhong, Changmin Qu, Baoyan Wang, Shuwen Liang, Bolun Zeng
The present study conducted a meta-analysis and systematic review of current evidence to assess the efficacy of probiotics in preventing or treating small intestinal bacterial overgrowth (SIBO). Relevant studies from PubMed, Embase, and the Cochrane Central Register of Controlled Trials, until May 2016, were assimilated. The prevention efficacy was assessed by the incidence of SIBO in the probiotic group, and the treatment efficacy by the SIBO decontamination rate, reduction in H2 concentration, and symptom improvement...
April 2017: Journal of Clinical Gastroenterology
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