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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/30383568/impact-of-cytomegalovirus-infection-on-the-outcome-of-patients-with-cirrhosis-a-preliminary-study
#1
Morgan Faivre, Vanessa Cottet, Jean-Baptiste Bour, Carine Richou, Séverine Valmary-Degano, Gerard Thiefin, Laurent Andreoletti, Claire Geist, Evelyne Schvoerer, Brice Malvé, François Habersetzer, Samira Fafi-Kremer, Christine Binquet, Jean-Louis Jouve, Jean-Pierre Bronowicki, Michel Doffoel, Patrick Hillon, Georges Herbein, Elisabeth Monnet, Vincent Di Martino
GOALS: The aims of this study were to evaluate whether cytomegalovirus (CMV) infection is associated with hepatocellular carcinoma (HCC) and liver-related mortality in cirrhotic patients. BACKGROUND: In cirrhotic patients, the determinants of HCC and liver-related death are imperfectly known. CMV infection, by its prooncogenic and proinflammatory properties, may favor both the development of HCC and deleterious systemic inflammation. STUDY: In the 1178 patients included between June 2008 and December 2012 in the CIrrhose et Risque de Carcinome Hépatocellulaire dans le grand-Est (CIRCE) study, a French multicenter case-control study designed to identify risk factors of HCC among cirrhotic patients, we identified 432 patients with interpretable CMV serological status at baseline...
October 31, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30383567/time-for-a-changing-of-guard-from-minimally-invasive-surgery-to-endoscopic-drainage-for-management-of-pancreatic-walled-off-necrosis
#2
Muhammad Ali Khan, Michel Kahaleh, Zubair Khan, Amy Tyberg, Shantanu Solanki, Khwaja F Haq, Aijaz Sofi, Wade M Lee, Mohammad K Ismail, Claudio Tombazzi, Todd H Baron
BACKGROUND AND AIMS: Endoscopic drainage (ED) with or without necrosectomy, and minimally invasive surgical necrosectomy (MISN) have been increasingly utilized for treatment of symptomatic sterile and infected pancreatic walled-off necrosis (WON). We conducted this systematic review to compare the safety of ED with MISN for management of WON. METHODS: We searched several databases from inception through November 9, 2017 to identify comparative studies evaluating the safety of ED versus MISN for management of WON...
October 31, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30358643/risk-of-renal-injury-after-the-use-of-polyethylene-glycol-for-outpatient-colonoscopy-a-prospective-observational-study
#3
Chi-Liang Cheng, Nai-Jen Liu, Jui-Hsiang Tang, Yen-Lin Kuo, Cheng-Hui Lin, Jau-Min Lien, Yi-Ning Tsui, Bai-Ping Lee, Hsiang-Ling Hung
GOAL: The goal of this study was to estimate the risk of renal injury after the use of 3-L polyethylene glycol (PEG) before outpatient colonoscopy. BACKGROUND: Population-based studies showed that the use of PEG was associated with renal injury, but this association has not been confirmed by prospective study. STUDY: Patients ≥40 years of age with an estimated glomerular filtration rate ≥30 mL/min were screened for enrollment. Laboratory data were collected before, during, and after the colonoscopies...
October 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30358642/financial-toxicity-in-crohn-s-disease
#4
Antanina Voit, Raymond K Cross, Emily Bellavance, Andrea C Bafford
BACKGROUND: A patient-reported outcome measure called Comprehensive Score for Financial Toxicity (COST) was previously developed and validated in patients with cancer. GOALS: We sought to assess the financial toxicity associated with Crohn's disease (CD) by administering the COST questionnaire to patients treated at a tertiary care center. STUDY: Forty-eight patients diagnosed with CD completed questionnaires, which included the COST quality of life instrument as well as questions with regard to sociodemographics and clinical characteristics...
October 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30346317/implementation-of-a-defecation-posture-modification-device-impact-on-bowel-movement-patterns-in-healthy-subjects
#5
Rohan M Modi, Alice Hinton, Daniel Pinkhas, Royce Groce, Marty M Meyer, Gokulakrishnan Balasubramanian, Edward Levine, Peter P Stanich
GOALS: The goal of this study was to evaluate the influence of defecation postural modification devices (DPMDs) on normal bowel patterns. BACKGROUND: The introduction of DPMDs has brought increased awareness to bowel habits in western populations. MATERIALS AND METHODS: A prospective crossover study of volunteers was performed that included real-time collection of data regarding bowel movements (BMs) for 4 weeks (first 2 wk without DPMD and subsequent 2 wk with DPMD)...
October 22, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30308546/comparison-between-an-oral-sulfate-solution-and-a-2-l-of-polyethylene-glycol-ascorbic-acid-as-a-split-dose-bowel-preparation-for-colonoscopy
#6
Han Hee Lee, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Bo-In Lee, Young-Seok Cho, In Seok Lee, Myung-Gyu Choi
BACKGROUND/AIMS: This study aimed to compare the efficacy and tolerability of an oral sulfate solution (OSS) versus 2 L of polyethylene glycol/ascorbic acid (2L-PEG/Asc) for bowel cleansing before colonoscopy. METHODS: A prospective, single-center, single-blinded, noninferiority, randomized, controlled trial was performed. The primary outcome was the rate of successful bowel cleansing, evaluated using the Boston Bowel Preparation Scale (BBPS). Secondary outcomes were examination time, polyp, and adenoma detection rate (PDR and ADR), tolerability, and safety...
October 10, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30285976/recent-trends-and-the-impact-of-the-affordable-care-act-on-emergency-department-visits-and-hospitalizations-for-gastrointestinal-pancreatic-and-liver-diseases
#7
Monique T Barakat, Aditi Mithal, Robert J Huang, Alka Sehgal, Amrita Sehgal, Gurkirpal Singh, Subhas Banerjee
BACKGROUND: The Affordable Care Act (ACA) with Medicaid expansion implemented in 2014, extended health insurance to >20-million previously uninsured individuals. However, it is unclear whether enhanced primary care access with Medicaid expansion decreased emergency department (ED) visits and hospitalizations for gastrointestinal (GI)/pancreatic/liver diseases. METHODS: We evaluated trends in GI/pancreatic/liver diagnosis-specific ED/hospital utilization over a 5-year period leading up to Medicaid expansion and a year following expansion, in California (a state that implemented Medicaid expansion) and compare these with Florida (a state that did not)...
October 3, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30285975/association-between-multidisciplinary-management-of-hepatocellular-carcinoma-and-patient-survival
#8
Yao-Ming Zhang, Zhen-Tao Zhou, Gao-Min Liu
No abstract text is available yet for this article.
October 3, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30260809/intestinal-hyperpermeability-in-gulf-war-veterans-with-chronic-gastrointestinal-symptoms
#9
Buyi Zhang, Meghan L Verne, Jeremy Z Fields, G Nicholas Verne, QiQi Zhou
BACKGROUND: Well over 700,000 United States military personnel participated in the Persian Gulf War in which they developed chronic health disorders of undetermined etiology. Up to 25% of Veterans had persistent and chronic gastrointestinal (GI) symptoms, which they suspected were related to their military service in the Gulf. AIM: The overall aim of the current study was to evaluate intestinal permeability in previously deployed Gulf War Veterans who developed chronic GI symptoms during their tour in the Persian Gulf...
September 26, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30222644/individual-and-geospatial-characteristics-associated-with-use-and-nonuse-of-the-fecal-immunochemical-test-fit-for-colorectal-cancer-screening-in-an-urban-minority-population
#10
Daryl Ramai, Denzil Etienne, Gloria Ayide, Paul J Fields, Madhavi Reddy
PURPOSE: Initiatives by the Centers for Disease Control and Prevention as well as the National Colorectal Cancer Roundtable aim to increase the rate of colorectal cancer (CRC) screening. We assess individual and geographic characteristics associated fecal immunochemical test (FIT) CRC screening over 3 years. METHODS: This is a retrospective study of 1500 FIT kits which were mailed or opportunistically handed to eligible participants in Brooklyn, New York from January 2014 to December 2016...
September 15, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30222643/bowel-preparation-with-polyethylene-glycol-3350-or-fasting-only-before-peroral-single-balloon-enteroscopy-a-randomized-european-multicenter-trial
#11
Frank Lenze, Tobias Nowacki, Sabine Schöppner, Hansjörg Ullerich, Dominik Bettenworth, Paola Soriani, Tommaso Gabbani, Vincenzo G Mirante, Dirk Domagk, Mauro Manno, Philipp Lenz
BACKGROUND: Although bowel preparation before colonoscopy and capsule endoscopy is widely evaluated and usually follows established guidelines, a standard preparation regime for peroral small bowel enteroscopy is yet to be defined.The aim of the present study was to compare small bowel preparation with polyethylene glycol (PEG) and "fasting only" (FO) before peroral single-balloon enteroscopy (SBE). STUDY: We compared small bowel preparation with PEG versus "FO" for peroral SBE in a randomized European multicenter trial...
September 15, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30222646/has-rotavirus-vaccination-decreased-the-prevalence-of-biliary-atresia
#12
Elizabeth Danial, Shannon Fleck-Derderian, Philip Rosenthal
OBJECTIVES: Biliary atresia (BA) is a rare neonatal liver disease that causes cholestasis and is the leading indication for pediatric liver transplantation. Although the exact etiology of BA remains unknown, evidence from murine models supports the role of rotavirus infection in the development of BA. In 2006, universal rotavirus vaccination was implemented in the United States. The goal of this study was to determine if the prevalence of BA correlated with the number of annual rotavirus infections...
September 14, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30180152/pretransplant-sarcopenia-in-patients-with-nash-cirrhosis-does-not-impact-rehospitalization-or-mortality
#13
Elizabeth S Aby, Edward Lee, Satvir S Saggi, Matthew R Viramontes, Jonathan F Grotts, Vatche G Agopian, Ronald W Busuttil, Sammy Saab
BACKGROUND: Malnutrition and muscle wasting are common in patients with end-stage liver disease (ESLD), yet go underdiagnosed. Frequently used indices of nutritional status, such as body mass index, are inflated in patients with ESLD due to a fluid overloaded state. Previous work has demonstrated a strong association between psoas muscle area, a surrogate for sarcopenia, and worse survival following liver transplantation; however, the impact of sarcopenia on post liver transplant outcomes in patients with nonalcoholic steatohepatitis (NASH) cirrhosis has not been evaluated...
September 1, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30180151/association-of-vitamin-d-and-parathyroid-hormone-with-barrett-s-esophagus
#14
Joel H Rubenstein, Daniel McConnell, David G Beer, Amitabh Chak, Valbona Metko, Gregory Clines
BACKGROUND: Esophageal adenocarcinoma has been inversely associated with exposure to ultraviolet radiation. This could be because of vitamin D deficiency or hyperparathyroidism promoting gastroesophageal reflux disease (GERD) and Barrett's esophagus. AIM: The aim of this study is to determine the association between parathyroid hormone (PTH) and vitamin D deficiency with GERD symptoms, erosive esophagitis, and Barrett's esophagus. METHODS: We assayed banked serum for PTH and total 25-hydroxy vitamin D from a cross-sectional cohort...
September 1, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30157063/acute-biliary-pancreatitis-is-associated-with-adverse-outcomes-in-the-elderly-a-propensity-score-matched-analysis
#15
Kishan Patel, Feng Li, Anjuli Luthra, Alice Hinton, Luis Lara, Royce Groce, Amy Hosmer, Sean T McCarthy, Sebastian Strobel, Darwin L Conwell, Somashekar G Krishna
GOALS AND BACKGROUND: In the elderly (age, 65 y or older), acute pancreatitis is most frequently because of gallstones; however, there is a paucity of national estimates evaluating outcomes of acute biliary pancreatitis (ABP). Hence, we utilized a representative population database to evaluate the outcomes of ABP among the elderly. STUDY: The National Readmission Database provides longitudinal follow-up of inpatients for 1 calendar-year. All adult inpatients (18 y or older) with an index primary admission for ABP between 2011 and 2014 were evaluated for clinical outcomes of mortality, severe acute pancreatitis (SAP), and 30-day readmission...
August 28, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30148766/factors-associated-with-potential-progressive-course-of-primary-biliary-cholangitis-data-from-real-world-us-database
#16
Zobair M Younossi, Maria Stepanova, Pegah Golabi, Robert S Epstein, Marcie E Strauss, Fatema Nader, Andrei Racila
BACKGROUND AND AIMS: Although relatively, primary biliary cholangitis (PBC) is an important cause of nonalcoholic chronic liver disease which may lead to liver transplantation. PBC patients with alkaline phosphatase (ALP) ≥1.5× the upper limit of normal (ULN) tend to have a more aggressive course. The study was designed to identify factors associated with ALP≥1.5×ULN or cirrhosis in PBC and to evaluate concomitant health care resource utilization. METHODS: We used a large real-world database that contained comprehensive and continuous electronic medical recored/claims data from over 500 health care practices or systems from the United States...
August 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30148765/relationships-of-microbiome-markers-with-extraintestinal-psychological-distress-and-gastrointestinal-symptoms-and-quality-of-life-in-women-with-irritable-bowel-syndrome
#17
Emily B Hollister, Kevin C Cain, Robert J Shulman, Monica E Jarrett, Robert L Burr, Cynthia Ko, Jasmine Zia, Claire J Han, Margaret M Heitkemper
INTRODUCTION: Altered microbial diversity has been associated with gastrointestinal (GI) symptoms in persons with irritable bowel syndrome (IBS). Less is known about the relationship of microbiome with extraintestinal pain and psychological distress symptoms and quality of life (QOL) in persons with IBS. We aimed to evaluate the relationship of fecal microbiota to GI symptoms, stool consistency, psychological distress, extraintestinal pain, and QOL in participants meeting Rome III criteria for IBS...
August 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30148764/peripartum-maternal-hepatitis-b-care-in-a-us-nationwide-data-set
#18
Matthew S Chang, J Frank Wharam, Fang Zhang, Robert F LeCates, Emma Morton-Eggleston, Ruth E Tuomala, Anna E Rutherford, Muthoka L Mutinga, Karin L Andersson, Robert S Brown, Chinweike Ukomadu, Emily Oken
BACKGROUND: Hepatitis B virus (HBV) screening during pregnancy is standard of care to prevent vertical transmission to infants, yet the mothers themselves may not receive appropriate follow-up. GOALS: Using a national database, we sought to determine rates of maternal peripartum follow-up with a HBV specialist and identify factors associated with a lack of follow-up. MATERIALS AND METHODS: We identified women who delivered in 2000 to 2012 and were diagnosed with HBV according to International Classification of Diseases-9 codes using a national database (Optum) derived from commercial insurance claims with ∼46 million members ages 0 to 64 in all 50 states...
August 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30300310/world-gastroenterology-organisation-wgo-news-and-events
#19
(no author information available yet)
No abstract text is available yet for this article.
November 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/30300262/vitamin-d-immunomodulatory-aspects
#20
Michele Miraglia Del Giudice, Cristiana Indolfi, Caterina Strisciuglio
Vitamin D is a group of liposoluble prohormones consisting of 5 different vitamins, the most important forms being vitamin D2 and vitamin D3. The ergocalciferol (vitamin D2) is less efficacious and derives from irradiated fungi, while colecalciferol (vitamin D3), derived from cholesterol, is synthesized via ultraviolet B rays in animal organisms. Only the ultraviolet B rays (290 to 315 nm) portion of the solar ray photolyzes 7-dehydrocholesterol in the skin to previtamin D3, which is converted subsequently to vitamin D3...
November 2018: Journal of Clinical Gastroenterology
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