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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/28697153/mucin-expression-in-the-esophageal-malignant-and-premalignant-states-a-systematic-review-and-meta-analysis
#1
Yaron Niv, Samuel B Ho, Ronnie Fass, Theodore Rokkas
BACKGROUND: Mucins are heavily glycosylated glycoproteins, synthesized by mucosal surfaces and have an important role in healthy state and malignant diseases. Change in mucins synthesis or secretion may be primary event or secondary to inflammation or carcinogenesis. AIM: The aim of this study is to assess the current knowledge about mucin expression in esophageal lesions, and to establish a role for different mucin expressions as prognostic markers. METHOD: English Medical literature searches were conducted for "mucin" and "esophagus...
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697152/transcutaneous-endoscopic-necrosectomy-for-walled-off-pancreatic-necrosis-in-the-paracolic-gutter
#2
Monica Saumoy, Nikhil A Kumta, Amy Tyberg, Elizabeth Brown, Micheal D Lieberman, Soumitra R Eachempati, Ronald S Winokur, Monica Gaidhane, Reem Z Sharaiha, Michel Kahaleh
BACKGROUND: Walled-off pancreatic necrosis (WON) is a sequelae of acute pancreatitis that requires debridement, once infected. Recently, endoscopic necrosectomy has become the mainstay for management. However, peripancreatic collections that extend to the paracolic gutter or lesser sac, are more challenging to treat endoscopically. We report an endoscopic method for management of necrotic collections that extend into the paracolic gutter. METHODS: Consecutive patients, with symptomatic WON extending into the retroperitoneum, were included in a prospective registry...
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697151/eus-guided-gastrojejunostomy-versus-laparoscopic-gastrojejunostomy-an-international-collaborative-study
#3
Manuel Perez-Miranda, Amy Tyberg, Daniel Poletto, Ernesto Toscano, Monica Gaidhane, Amit P Desai, Nikhil A Kumta, Lea Fayad, Jose Nieto, Marc Barthet, Raj Shah, Brian C Brauer, Reem Z Sharaiha, Michel Kahaleh
INTRODUCTION: Endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) with placement of a lumen-apposing metal stent is a minimally invasive and efficacious procedure for gastric outlet obstruction (GOO) patients not amenable to surgery. Laparoscopic gastrojejunostomy (Lap-GJ) has traditionally been the standard of care. No direct comparison between EUS-GJ and Lap-GJ has been described. Our aim was to compare the clinical outcomes, success rate, and adverse events (AE) of EUS-GJ with Lap-GJ...
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697150/endoscopic-retrograde-cholangiopancreatography-ercp-and-acute-cholangitis-the-sooner-the-better
#4
Emmanuel I González-Moreno, Joel O Jáquez-Quintana, José A González-González, Héctor J Maldonado-Garza
No abstract text is available yet for this article.
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697149/the-influence-of-statins-on-risk-and-patient-survival-in-colorectal-cancer
#5
Baoge Qu, Hao Qu
No abstract text is available yet for this article.
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697148/consideration-of-clinical-context-and-alternative-therapies-in-aggressive-resuscitation-for-prevention-of-post-ercp-pancreatitis
#6
Anna E Phillips, Georgios I Papachristou, Adam Slivka
No abstract text is available yet for this article.
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697147/reply-to-potential-pitfalls-when-assessing-the-impact-of-cytomegalovirus-in-inflammatory-bowel-disease
#7
Laurie B Grossberg, Kenneth Falchuk, Joseph D Feuerstein
No abstract text is available yet for this article.
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28697146/gastric-reflux-into-the-gallbladder-after-eus-guided-stenting-letter-to-the-editor-regarding-eus-guided-versus-percutaneous-gallbladder-drainage-isn-t-it-time-to-convert
#8
Joseph J Kim, Spiros P Hiotis, Malini D Sur
No abstract text is available yet for this article.
July 10, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28654554/baseline-hepatitis-b-virus-titer-predicts-initial-postpartum-hepatic-flare-a-multicenter-prospective-study
#9
Jinfeng Liu, Jing Wang, Caijing Qi, Furong Cao, Zhen Tian, Dandan Guo, Taotao Yan, Qian Li, Shujuan Yang, JianJun Fu, Xianmei Tang, Xiaoni Kou, Na Liu, Zicheng Jiang, Yingren Zhao, Tianyan Chen
BACKGROUND AND GOALS: A series of changes in the immune system occur during pregnancy and puerperium. Currently, we aim to characterize both the natural changes in liver inflammation and its association with hepatitis B viremia during this special period. PATIENTS AND METHODS: Chronic hepatitis B (CHB) gravidas were recruited and followed up to 52 weeks postpartum. Virological and biochemical parameters were assessed throughout the period. RESULTS: A total of 1097 CHB mothers had finished the entire follow-up including 451 accepting telbivudine, 178 accepting tenofovir, and 468 without antiviral therapy...
June 26, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28654553/clinical-and-histopathologic-features-of-colorectal-adenocarcinoma-in-crohn-s-disease
#10
Christian Galata, Daniela Hirsch, Wolfgang Reindl, Stefan Post, Peter Kienle, Michael Boutros, Timo Gaiser, Karoline Horisberger
GOALS: The aim of this study was to assess the histopathologic characteristics of colorectal carcinomas (CRC) in patients with Crohn's disease (CD). BACKGROUND: A higher frequency of microsatellite instability (MSI) is seen in mucinous compared with nonmucinous CRC which suggests that its pathogenesis involves distinct molecular pathways. Several publications reported a higher percentage of mucinous adenocarcinoma in CD patients with CRC. So far, there has been no investigation of MSI in CD patients with mucinous CRC...
June 26, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644316/a-multicenter-evaluation-of-adherence-to-4-major-elements-of-the-baveno-guidelines-and-outcomes-for-patients-with-acute-variceal-hemorrhage
#11
Elliot B Tapper, Jennifer Friderici, Zachary A Borman, Jacob Alexander, Alan Bonder, Nabiha Nuruzzaman, Sheryl Ramdass, Rony Ghaoui
GOALS: To determine the rate of and outcomes associated with guideline adherence in the care of acute variceal hemorrhage (AVH). BACKGROUND: Four major elements of high-quality care for AVH defined by the Baveno consensus (VI) include timely endoscopy (≤12 h), antibiotics, and somatostatin analogs before endoscopy and band ligation as primary therapy for esophageal varices. STUDY: We retrospectively evaluated 239 consecutive admissions of 211 patients with AVH admitted to 2 centers in Massachusetts from 2010 to 2015...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644315/management-of-eosinophilic-esophagitis-based-on-pathophysiological-evidence
#12
Bram D van Rhijn, Albert J Bredenoord
Over the past decades eosinophilic esophagitis (EoE) has been increasingly diagnosed, and significant progress has been made in our understanding of its pathophysiology. As EoE cannot be cured yet, treatment goals are suppression of disease activity and symptoms as well as the prevention of progression to a more severe disease phenotype. Disease-modifying treatment options can be divided into dietary therapy and immunosuppressive medications, of which topical steroids have been most investigated, yet are still prescribed off-label...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644314/prone-or-left-for-colonoscopy-a-randomized-controlled-trial-of-prone-versus-left-sided-starting-position-for-colonoscopy
#13
Nikhil Vergis, Alexander J Scarborough, James A Morris, Jonathan M Hoare
BACKGROUND AND AIMS: Data have emerged supporting the right-lateral starting position in reducing time to cecum and improving patient comfort for minimally sedated colonoscopy. We aimed to test whether prone starting position results in similar advantages in procedure time and patient tolerability in comparison to traditional left-sided starting position. MATERIALS AND METHODS: We conducted a randomized controlled trial in which patients were randomized to begin in either the prone or left-lateral (LL) position...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644313/unique-clinical-features-of-los-angeles-grade-d-esophagitis-suggest-that-factors-other-than-gastroesophageal-reflux-contribute-to-its-pathogenesis
#14
Anh D Nguyen, Stuart J Spechler, Monique N Shuler, Rhonda F Souza, Kerry B Dunbar
BACKGROUND: The Los Angeles (LA) grade of reflux esophagitis (A to D) is assumed to reflect severity of the underlying gastroesophageal reflux disease (GERD). Thus, LA-D esophagitis patients might be expected to have the most conditions predisposing to GERD (eg, obesity, hiatal hernia), and the highest frequency of GERD symptoms. GOALS: The main goal of this study is to compare clinical features of patients with the most severe (LA-D) and mildest (LA-A) grades of esophagitis...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644312/early-infections-and-the-risk-of-irritable-bowel-syndrome-a-case-control-study
#15
Edward J Krajicek, Ann E Almazar, Joseph J Larson, Elizabeth J Atkinson, Nicholas J Talley, Yuri A Saito
GOALS: The goal of this study is to evaluate the association between early life infections and subsequent adult onset irritable bowel syndrome (IBS). BACKGROUND: Infections during adulthood are a known risk factor for adult-onset IBS. This investigation examined the role of childhood infections and infection risk factors in the development of IBS symptoms. STUDY: In total, 1010 subjects (509 outpatients with IBS, 501 matched controls) were mailed questionnaires regarding early-life infections during infancy (0 to 12 mo), toddler years (1 to 3 y), and child years (4 to 18 y)...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644311/hemobilia-an-uncommon-but-notable-cause-of-upper-gastrointestinal-bleeding
#16
Scott Cathcart, John W Birk, Michael Tadros, Micheal Schuster
GOAL AND BACKGROUND: A literature review to improve practitioners' knowledge and performance concerning the epidemiology, diagnosis, and management of hemobilia. STUDY: A search of Pubmed, Google Scholar, and Medline was conducted using the keyword hemobilia and relevant articles were reviewed and analyzed. The findings pertaining to hemobilia etiology, investigation, and management techniques were considered and organized by clinicians practiced in hemobilia. RESULTS: The majority of current hemobilia cases have an iatrogenic cause from either bile duct or liver manipulation...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644310/predictors-of-mortality-in-cirrhosis-inpatients-with-clostridium-difficile-infection
#17
Elliot Z Smith, Patrick G Northup, Curtis K Argo
BACKGROUND: Clostridium difficile is a bacterial pathogen associated with significant morbidity and mortality in patients with cirrhosis. GOALS: Our primary aim is to identify variables that are predictive of poor outcomes in cirrhosis patients with C. difficile infection (CDI). We also aim to further characterize the risk factors for developing CDI and risk of mortality in this patient population. STUDY: A total of 200 subjects with a diagnosis of cirrhosis and CDI were matched to 200 cirrhosis inpatients without CDI...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644309/the-use-of-a-stylet-in-endoscopic-ultrasound-with-fine-needle-aspiration-a-systematic-review-and-meta-analysis
#18
Andrew Lai, Ashley Davis-Yadley, Seth Lipka, Miguel Lalama, Roshanak Rabbanifard, David Bromberg, Roger Nehaul, Ambuj Kumar, Prasad Kulkarni
BACKGROUND: Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is the most efficacious way to collect specimens from a solid lesion adjacent to the gastrointestinal tract and is performed with an internal stylet during puncture. However, its reinsertion into the needle is time-consuming. Controversy surrounds whether quality of cytology specimen improves with stylet use. We performed a meta-analysis comparing the use of stylet versus no stylet with EUS-FNA of gastrointestinal-related masses...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644308/the-use-of-5-aminosalicylic-acid-in-children-and-adolescents-with-inflammatory-bowel-disease
#19
Christiane Sokollik, Nicolas Fournier, David Rizzuti, Christian P Braegger, Andreas Nydegger, Susanne Schibli, Johannes Spalinger
BACKGROUND: In ulcerative colitis (UC) 5-aminosalicylic acid (5-ASA) is recommended as primary therapy for mild to moderate disease. Topical 5-ASA has been proven especially effective. In Crohn's disease (CD) the evidence for a beneficial role of 5-ASA is weak. We investigated the use of topical and systemic 5-ASA therapy in children and adolescents with inflammatory bowel disease. MATERIALS AND METHODS: Data of patients younger than 18 years, registered between April 2008 and December 2015 in the Swiss Inflammatory Bowel Disease Cohort, were analyzed...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28617762/racial-disparities-and-sociodemographic-differences-in-incidence-and-survival-among-pediatric-patients-in-the-united-states-with-primary-liver-cancer-a-surveillance-epidemiology-and-end-results-seer-population-study
#20
Felix Nautsch, Johannes M Ludwig, Minzhi Xing, Kevin M Johnson, Hyun S Kim
BACKGROUND: Primary liver cancer, including Hepatoblastoma (HB) and hepatocellular carcinoma (HCC), in pediatric populations is often fatal. The outcomes are poor despite universal health care access in pediatric patients. AIM: We investigated the sociodemographic factors affecting outcomes in pediatric patients with primary liver cancer. MATERIALS AND METHODS: This is a large population database study of Surveillance, Epidemiology, and End Results cancer registry data from 1973 to 2011...
June 14, 2017: Journal of Clinical Gastroenterology
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