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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/29782471/new-approach-in-acne-therapy-a-specific-bacteriocin-activity-and-a-targeted-anti-il-8-property-in-just-1-probiotic-strain-the-l-salivarius-ls03
#1
Francesca Deidda, Angela Amoruso, Stefania Nicola, Teresa Graziano, Marco Pane, Luca Mogna
GOALS: The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release. BACKGROUND: Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics, have limited use. Thus, development of novel agents to treat this disease is needed...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782470/characterizing-abdominal-pain-in-patients-with-gastroparesis-into-neuropathic-and-nociceptive-components
#2
Asad Jehangir, Rany T Abdallah, Henry P Parkman
INTRODUCTION: The cause of abdominal pain (AP) in gastroparesis (Gp) is often not known; hence, its treatment can be challenging. Preoccupation with or increased attention (hypervigilance) to pain is associated with perceived pain severity and psychosocial disability. The aims of this study were to (1) characterize AP in Gp patients into neuropathic and nociceptive pain components; (2) assess these patients for hypervigilance to pain. MATERIALS AND METHODS: Gp patients with AP as an important symptom, seen from June 2017 to November 2017 were given validated questionnaires to characterize their AP...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782469/effectiveness-of-probiotics-in-children-with-functional-abdominal-pain-disorders-and-functional-constipation-a-systematic-review
#3
Carrie A M Wegh, Marc A Benninga, Merit M Tabbers
OBJECTIVE: The objective of this study was to investigate the effect of probiotics on functional abdominal pain disorders (FAPD) and functional constipation (FC). METHODS: A systematic review was conducted, searching PubMed and Cochrane databases from inception to January 2018 for randomized controlled trials (RCTs) investigating the efficacy of probiotics in children aged 4 to 18 years with FAPD or children aged 0 to 18 years with FC. RESULTS: A total of 657 citations were identified...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782468/potential-role-of-gut-microbiota-in-als-pathogenesis-and-possible-novel-therapeutic-strategies
#4
Letizia Mazzini, Luca Mogna, Fabiola De Marchi, Angela Amoruso, Marco Pane, Irene Aloisio, Nicole Bozzi Cionci, Francesca Gaggìa, Ausiliatrice Lucenti, Enrica Bersano, Roberto Cantello, Diana Di Gioia, Giovanni Mogna
BACKGROUND: Recent preclinical studies suggest that dysfunction of gastrointestinal tract may play a role in amyotrophic lateral sclerosis (ALS) pathogenesis through a modification of the gut microbiota brain axis. Our study is the first focused on microbiota analysis in ALS patients. AIM: Our aim was to study the main human gut microbial groups and the overall microbial diversity in ALS and healthy subjects. Moreover we have examined the influence of a treatment with a specific bacteriotherapy composed of Lactobacillus strains (Lactobacillus fermentum, Lactobacillus delbrueckii, Lactobacillus plantarum, Lactobacillus salivarius) acting on the gastrointestinal barrier...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782467/age-and-crc-risk-in-the-serrated-pathway
#5
Joseph C Anderson, Joel B Levine
No abstract text is available yet for this article.
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782466/mucin-expression-in-colorectal-cancer-crc-systematic-review-and-meta-analysis
#6
Yaron Niv, Theodore Rokkas
BACKGROUND: A body of evidence has suggested that mucins play an important role in adhesion, invasion, and cancer metastasis. However, this evidence is scarce and sometimes confusing. OBJECTIVE: We performed a systematic review and meta-analysis of available studies to better define the role of mucins in the behavior of colorectal cancer (CRC). METHODS: Medical literature was searched through November 30, 2017, using suitable keywords. Pooled estimates, that is, odd ratios (ORs), were obtained using fixed or random-effects models, as appropriate...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782465/gamma-delta-t-lymphocytes-in-the-diagnostic-approach-of-coeliac-disease
#7
Petula Nijeboer, Tom van Gils, Martine Reijm, Rogier Ooijevaar, Birgit I Lissenberg-Witte, Hetty J Bontkes, Chris J J Mulder, Gerd Bouma
GOALS: To validate cut-off values of CD3 T-cell receptor gamma-delta chain (TCRγδ) intraepithelial lymphocyte (IEL) in the (differential) diagnosis of celiac disease (CD). BACKGROUND: CD is characterized by an increase in gamma-delta IEL (CD3TCRγδ IEL). STUDY: Percentages were determined by flow cytometric analysis of IELs from small bowel biopsies in 213 CD and 13 potential CD (PCD) patients and in total 112 controls. A cut-off value for percentages of CD3TCRγδ IEL to differentiate active CD and controls was obtained from a receiver operating characteristic curve and implemented in controls and PCD patients...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782464/use-of-probiotics-in-the-prevention-of-nosocomial-infections
#8
Ivana Trivić, Iva Hojsak
Nosocomial, hospital-acquired or health care-associated infections occur worldwide, affecting both developed and developing countries. This results in a prolonged hospital stay, increased antimicrobial resistance, increased mortality rate, and significant financial burden on the health care system. Routine preventive measures have led to the decrease in infection spreading; however, it cannot successfully prevent all of them, making a place for the development of new strategies, including probiotics. The aim of this review was to summarize available evidence of the role of probiotics in the prevention of nosocomial infections in children...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782463/gut-microbiota-probiotics-and-sport-from-clinical-evidence-to-agonistic-performance
#9
Marco Pane, Angela Amoruso, Francesca Deidda, Teresa Graziano, Serena Allesina, Luca Mogna
Human beings harbor clusters of bacteria in different parts of the body, such as the surface or the deep layers of the skin, the mouth, the lungs, the intestine, the vagina, and all the surfaces exposed to the outer world. The majority of microbes resides in the gut, have a weighty influence on human physiology and nutrition and are vital for human life. There is growing evidence showing that the gut microbiota plays important roles in the maturation of the immune system and the protection against some infectious agents...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29762266/flow-cytometry-evolution-of-microbiological-methods-for-probiotics-enumeration
#10
Marco Pane, Serena Allesina, Angela Amoruso, Stefania Nicola, Francesca Deidda, Luca Mogna
GOALS: The purpose of this trial was to verify that the analytical method ISO 19344:2015 (E)-IDF 232:2015 (E) is valid and reliable for quantifying the concentration of the probiotic Lactobacillus rhamnosus GG (ATCC 53103) in a finished product formulation. BACKGROUND: Flow cytometry assay is emerging as an alternative rapid method for microbial detection, enumeration, and population profiling. The use of flow cytometry not only permits the determination of viable cell counts but also allows for enumeration of damaged and dead cell subpopulations...
May 14, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29762265/link-between-celiac-disease-and-inflammatory-bowel-disease
#11
Ayesha Shah, Marjorie Walker, Daniel Burger, Neal Martin, Moritz von Wulffen, Natasha Koloski, Mike Jones, Nicholas J Talley, Gerald J Holtmann
GOAL: The aim of this analysis was to assess in patients with inflammatory bowel disease (IBD) the risk of celiac disease and in celiac disease patients the risk of IBD. BACKGROUND: Previous studies report a possible association between IBD and celiac disease; however, this link is controversial. STUDY: Using the search terms "inflammatory bowel disease" and "celiac disease," we identified initially 1525 publications. In total 27 studies met inclusion criteria...
May 14, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29738352/the-effect-of-obesity-on-the-quality-of-bowel-preparation-for-colonoscopy-results-from-a-large-observational-study
#12
Ava B Anklesaria, Elena A Ivanina, Kenechukwu O Chudy-Onwugaje, Kevin Tin, Chaya M Levine, Peter Homel, Mary Rojas, Ira E Mayer, Rabin Rahmani
BACKGROUND: Obesity has been linked to suboptimal bowel preparation but this association has not been conclusively investigated in prospective studies. GOALS: Our objective was to determine whether any relationship exists between obesity as measured by body mass index (BMI) and quality of bowel preparation. STUDY: Adult patients who presented for outpatient colonoscopy at a single urban ambulatory surgery center within a 6-month period and fulfilled inclusion criteria were prospectively enrolled for the study...
May 5, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29734211/early-versus-standard-colonoscopy-a-randomized-controlled-trial-in-patients-with-acute-lower-gastrointestinal-bleeding-results-of-the-bleed-study
#13
Inge van Rongen, Bregje J W Thomassen, Lars E Perk
GOALS: The aim of our study was to examine differences in length of hospital stay (LOHS) between patients with lower gastrointestinal bleeding who received either an early colonoscopy (within 24 h of presentation) or a standard colonoscopy (within 1 to 3 d). BACKGROUND: Diagnostic management of lower gastrointestinal bleeding has been extensively debated in recent literature, especially whether colonoscopy within 24 hours of presentation is feasible and safe...
May 4, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29734210/effectiveness-of-multistrain-versus-single-strain-probiotics-current-status-and-recommendations-for-the-future
#14
Arthur C Ouwehand, Marcos M Invernici, Flávia A C Furlaneto, Michel R Messora
Probiotics are investigated as single-strain and multistrain products. In the market, however, there is an increasing tendency to work with multistrain probiotics, in particular, products with a high number of different strains. There are some thoughts behind this: more strains imply more chances of success; it can mean a broader spectrum of efficacy, and there is often the hope that there are at least additive and, potentially, even synergistic effects. The present review did not find convincing evidence that these assumptions are valid...
May 4, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29697498/successful-cholecystectomy-after-endoscopic-ultrasound-gallbladder-drainage-compared-with-percutaneous-cholecystostomy-can-it-be-done
#15
Monica Saumoy, Amy Tyberg, Elizabeth Brown, Soumitra R Eachempati, Michael Lieberman, Cheguevara Afaneh, Rastislav Kunda, Natalie Cosgrove, Ali Siddiqui, Monica Gaidhane, Michel Kahaleh
BACKGROUND: Endoscopic ultrasound-guided gallbladder drainage (EGBD) with a lumen apposing metal stent is becoming a widely accepted alternative to percutaneous gallbladder drainage (PTGD) for patients who are not candidates for cholecystectomy (CCY). In some patients, medical comorbidites can improve, allowing them to undergo CCY. We compare feasibility and outcomes of interval CCY after EGBD versus PTGD. METHODS: We conducted a multicentered international cohort study of patients who underwent EGBD or PTGD and then underwent interval CCY...
April 24, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29688917/large-volume-fluid-resuscitation-for-severe-acute-pancreatitis-is-associated-with-reduced-mortality-a-multicenter-retrospective-study
#16
Takahiro Yamashita, Masayasu Horibe, Masamitsu Sanui, Mitsuhito Sasaki, Hirotaka Sawano, Takashi Goto, Tsukasa Ikeura, Tsuyoshi Hamada, Takuya Oda, Hideto Yasuda, Yuki Ogura, Dai Miyazaki, Kaoru Hirose, Katsuya Kitamura, Nobutaka Chiba, Tetsu Ozaki, Toshitaka Koinuma, Taku Oshima, Tomonori Yamamoto, Morihisa Hirota, Yukiko Masuda, Natsuko Tokuhira, Mioko Kobayashi, Shinjiro Saito, Junko Izai, Alan K Lefor, Eisuke Iwasaki, Takanori Kanai, Toshihiko Mayumi
BACKGROUND AND AIMS: Although fluid resuscitation is critical in acute pancreatitis, the optimal fluid volume is unknown. The aim of this study is to evaluate the association between the volume of fluid administered and clinical outcomes in patients with severe acute pancreatitis (SAP). METHODS: We conducted a multicenter retrospective study at 44 institutions in Japan. Inclusion criteria were age 18 years or older, and diagnosed with SAP from 2009 to 2013. Patients were stratified into 2 groups: administered fluid volume <6000 and ≥6000 mL in the first 24 hours...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29688916/gastrointestinal-bleeding-with-left-ventricular-assist-devices-lvad-locating-the-leak-and-identifying-outcomes
#17
Sarah Malik, Shahbaz A Malik, Laura L Ulmer, Lokesh K Jha, Michael S Strupp, Eugenia Raichlin, Elizabeth R Lyden, Alexander T Hewlett
BACKGROUND AND GOALS: Gastrointestinal bleeding (GIB) is a significant complication following left ventricular assist device (LVAD) implantation. We evaluated the incidence, predictors, endoscopic findings, and outcomes of GIB in LVAD recipients. STUDY: Retrospective review of 205 adult patients undergoing HeartMate II LVAD implantation from January 2012 to June 2016. Patients were reviewed and separated into GIB (n=57; 28%) and non-GIB (n=148; 72%) groups. RESULTS: Median time to GIB was 55 (range, 3 to 730) days...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29688915/clinical-and-microbiological-effect-of-a-multispecies-probiotic-supplementation-in-celiac-patients-with-persistent-ibs-type-symptoms-a-randomized-double-blind-placebo-controlled-multicenter-trial
#18
Ruggiero Francavilla, Maria Piccolo, Antonio Francavilla, Lorenzo Polimeno, Francesco Semeraro, Fernanda Cristofori, Stefania Castellaneta, Michele Barone, Flavia Indrio, Marco Gobbetti, Maria De Angelis
GOALS: The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). BACKGROUND: About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. STUDY: CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29672439/cajal-cell-counts-are-important-predictors-of-outcomes-in-drug-refractory-gastroparesis-patients-with-neurostimulation
#19
Endashaw Omer, Archana Kedar, Harsha S Nagarajarao, Yana Nikitina, Vetta Vedanarayanan, Charu Subramony, Christopher J Lahr, Thomas L Abell
BACKGROUND AND AIMS: Cajal cells serve as the pacemaker cells of the gastrointestinal tract and regulates peristalsis. On the baisis of that fact, it has been hypothesized that a decrease in Cajal cells can lead to gastroparesis and other motility issues. Treatment with medications has a limited efficacy and most resort to gastric electrical stimulation (GES) devices for symptomatic relief. We believe that the number of Cajal cells present is directly proportional to symptomatic relief with GES...
April 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29672438/alterations-of-inflammatory-and-matrix-production-indices-in-celiac-disease-with-low-bone-mass-on-long-term-gluten-free-diet
#20
Michele Di Stefano, Manuela Bergonzi, Irene Benedetti, Mara De Amici, Cristina Torre, Natascia Brondino, Emanuela Miceli, Elisabetta Pagani, Gian L Marseglia, Gino R Corazza, Antonio Di Sabatino
BACKGROUND: A clinically meaningful impairment of bone mass secondary to malabsorption is frequent in untreated celiac disease. In adult patients, a rigorous gluten-free diet (GFD) significantly improves, but does not always normalize, bone mineral density (BMD). The reason for this marginal response is unclear. Accordingly, we evaluated the role of both local and systemic factors for bone loss in celiac patients on long-term GFD. STUDY: In a prospective cohort, 22 patients with low lumbar and/or femoral BMD and 22 with normal BMD underwent bone and mineral metabolism evaluation: we tested calcium, phosphate, parathyroid hormone, and vitamin D; telopeptide of type I collagen, a bone resorption index; propeptide of type I procollagen, a bone neoformation index; receptor antagonist of NF-kB ligand, an osteoclast-stimulating factor; osteoprotegerin (OPG), a decoy receptor for RANKL...
April 18, 2018: Journal of Clinical Gastroenterology
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