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Journal of Clinical Gastroenterology

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https://www.readbyqxmd.com/read/28323748/serum-aminotransferase-flares-in-pregnant-and-postpartum-women-with-current-or-prior-treatment-for-chronic-hepatitis-b
#1
Christine Y Chang, Natali Aziz, Mugilan Poongkunran, Asad Javaid, Huy N Trinh, Daryl T Lau, Mindie H Nguyen
BACKGROUND AND AIMS: Antiviral therapy is recommended for pregnant women with chronic hepatitis B (CHB) and hepatitis B virus (HBV) DNA>200,000 IU/mL, but there is less consensus on management of women who discontinue therapy in anticipation of pregnancy or who become pregnant while on therapy. The goal of this study was to describe flares in alanine aminotransferase (ALT) during pregnancy and postpartum in CHB women with current and/or prior treatment. METHODS: This was a multicenter, retrospective study of 67 pregnancies in 56 CHB women treated before and/or during pregnancy...
March 20, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28296656/severity-and-outcome-of-acute-on-chronic-liver-failure-is-dependent-on-the-etiology-of-acute-hepatic-insults-analysis-of-368-patients
#2
Shalimar, Saurabh Kedia, Soumya J Mahapatra, Baibaswata Nayak, Deepak Gunjan, Bhaskar Thakur, Subrat K Acharya
BACKGROUND: Acute-on-chronic liver failure (ACLF) may be precipitated by various hepatic insults. The present study evaluated the outcomes of ACLF with different acute insults. PATIENTS AND METHODS: A total of 368 ACLF patients were included. Data collected included etiologies of acute hepatic insult and underlying chronic liver disease, and organ failure. Model for end-stage liver disease (MELD), chronic liver failure consortium (CLIF)-C ACLF, and acute physiology and chronic health evaluation (APACHE) II scores were calculated...
March 14, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28291175/ppi-trial-for-eosinophilic-esophagitis-chaos-in-the-community
#3
Seth Lipka, Ambuj Kumar, Joel E Richter
INTRODUCTION: Despite consensus eosinophilic esophagitis (EoE) statement published in 2011 calling for a 2-month trial of protons pump inhibitor (PPI), the guidelines are not followed by many. We studied the practice patterns in our community and response to a PPI retrial in patients previously diagnosed with "idiopathic EoE." METHODS: All patients presenting to the senior author's practice with suspected EoE from 2011 to 2015. Two cohorts were studied: (1) patients diagnosed in the community as "idiopathic EoE"; (2) treatment naïve patients given a PPI trial at University of South Florida...
March 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28277375/potential-pitfalls-when-assessing-the-impact-of-cytomegalovirus-in-inflammatory-bowel-disease
#4
Jeffrey D McCurdy, David H Bruining, Edward V Loftus
No abstract text is available yet for this article.
March 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28277374/clinical-predictors-for-kras-codon-13-mutations-in-patients-with-colorectal-cancer
#5
Min S Kwak, Jae M Cha, Young H Cho, Sang H Kim, Jin Y Yoon, Jung W Jeon, Hyun P Shin, Kwang R Joo, Joung I Lee
GOALS: This study sought to clarify sex differences in KRAS mutations and clinical predictors of KRAS 13 codon mutations. BACKGROUND: Sex differences in KRAS mutations and predictors for KRAS codon 13 mutations in colorectal cancer (CRC) are unclear. STUDY: Between October 2007 and May 2016, 328 patients underwent surgery for CRCs that were analyzed for KRAS mutations at a referral university hospital. Sex differences in the rates and distributions of KRAS mutations, and factors predictive of overall KRAS and KRAS codon 13 mutations were analyzed...
March 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28272079/natural-history-and-treatment-outcomes-of-severe-autoimmune-hepatitis
#6
Nikhil Sonthalia, Pravin M Rathi, Samit S Jain, Ravindra G Surude, Ashok R Mohite, Sunil V Pawar, Qais Contractor
GOALS: The aim of this study was to analyze the natural history and treatment outcomes of autoimmune hepatitis (AIH) variants presenting with severe-AIH. BACKGROUND: Severe acute presentation is an uncommon manifestation of AIH, and it remains poorly characterized. MATERIALS AND METHODS: We included 101 patients with AIH from January 2011 to December 2015. Patients were classified as seropositive-AIH and seronegative-AIH. Patients with acute liver failure, acute-on-chronic liver failure, and severe acute hepatitis were defined as severe-AIH patients...
March 7, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28266939/resumption-of-warfarin-after-hospitalization-for-lower-gastrointestinal-bleeding-and-mortality-benefits
#7
Parita Patel, Neha Nigam, Neil Sengupta
GOALS: To evaluate whether resumption of warfarin after hospitalization for lower gastrointestinal bleeding (LGIB) is associated with improved 90-day and 6-month survival. BACKGROUND: LGIB is a common complication for patients on warfarin. There is limited data to guide clinicians on the optimal management of warfarin following hospitalization for LGIB. STUDY: We identified patients hospitalized with LGIB while on warfarin using a validated, machine-learning algorithm...
March 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28263238/evaluation-of-effects-of-radiofrequency-ablation-of-ex-vivo-liver-using-the-1-fr-wire-electrode
#8
Tarun Rustagi, Ferga C Gleeson, Barham K Abu Dayyeh, Mark D Topazian, Michael J Levy
BACKGROUND AND STUDY AIMS: Percutaneous and intraoperative radiofrequency ablation (RFA) has become a valued tool in the management of primary and secondary hepatic lesions. A recent FDA-approved endoscopic ultrasound (EUS)-guided RFA probe now offers promise to help manage such lesions. However, there are no data to determine the ideal power setting and duration of ablation needed to effectively treat hepatic masses. The aim of the study was to evaluate the macroscopic zone of hepatic injury for EUS-RFA using a variety of settings within a fresh porcine hepatic specimen...
March 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28157734/accuracy-of-consecutive-fecal-calprotectin-measurements-to-predict-relapse-in-inflammatory-bowel-disease-patients
#9
Cong Dai, Qin Cao, Min Jiang
No abstract text is available yet for this article.
February 2, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28134636/role-of-circulating-and-supplemental-calcium-and-vitamin-d-in-the-occurrence-and-development-of-colorectal-adenoma-or-colorectal-cancer
#10
Baoge Qu, Honggang Zhan, Qu Hao
No abstract text is available yet for this article.
January 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28134635/efficacy-durability-and-safety-of-complete-endoscopic-mucosal-resection-of-barrett-esophagus-a-systematic-review-and-meta-analysis
#11
Yutaka Tomizawa, Vani J A Konda, Emmanuel Coronel, Christopher G Chapman, Uzma D Siddiqui
GOALS: To report the rate of eradication and recurrence of both neoplasia and intestinal mucosa and the rate of adverse events for complete endoscopic resection (CER) of Barrett esophagus (BE). BACKGROUND: There is limited composite data on the clinical efficacy of CER of BE with high-grade dysplasia or neoplasia. STUDY: We performed a systematic review and meta-analysis of cohort studies that reported the clinical outcome of patients with BE who underwent CER and had at least 15-month follow-up after the time of elimination of BE...
January 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28134634/delayed-bleeding-following-cold-snare-polypectomy-for-small-colorectal-polyps-in-patients-taking-antithrombotic-agents
#12
Toshiyuki Makino, Akira Horiuchi, Masashi Kajiyama, Naoki Tanaka, Kenji Sano, Iruru Maetani
BACKGROUND: This study compared the incidence of delayed bleeding following 2 methods of cold snare polypectomy for colorectal polyps in patients taking antithrombotic agents. METHODS: Patients undergoing cold snare polypectomy for colorectal polyps ≤10 mm without discontinuation of antithrombotic agents were enrolled. This was a retrospective study of a prospectively collected cohort based on a historical comparison of 2 time periods. A traditional cold snare was used between January 2012 and December 2013 and a dedicated cold snare was used between January 2014 and December 2015...
January 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28134633/small-intestinal-bacterial-overgrowth-is-associated-with-concurrent-intestinal-inflammation-but-not-with-systemic-inflammation-in-crohn-s-disease-patients
#13
José E R Ricci, Liliana A Chebli, Tarsila C D R Ribeiro, Antonio C S Castro, Pedro D Gaburri, Fabio H D L Pace, Kátia V B D Barbosa, Lincoln E V V D C Ferreira, Maria D C F Passos, Carla Malaguti, Álvaro H D A Delgado, Jacqueline D Campos, André R Coelho, Julio M F Chebli
GOALS: We studied the prevalence and predictors of small-intestinal bacterial overgrowth (SIBO) in Crohn's disease (CD) outpatients and the relationship between SIBO and intestinal and/or systemic inflammation. BACKGROUND: The relationship of SIBO with systemic and intestinal inflammation in CD patients is unclear. STUDY: In this cross-sectional study, conducted between June, 2013 and January, 2015, 92 CD patients and 97 controls with nonchronic gastrointestinal complaints were assessed for the presence of SIBO using the H2/CH4 glucose breath test...
January 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28098578/helicobacter-pylori-and-risk-of-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#14
Karn Wijarnpreecha, Charat Thongprayoon, Panadeekarn Panjawatanan, Wuttiporn Manatsathit, Veeravich Jaruvongvanich, Patompong Ungprasert
BACKGROUND/OBJECTIVES: Helicobacter pylori (H. pylori) is the most common chronic bacterial infection. Patients with H. pylori infection may be at an increased risk of nonalcoholic fatty liver disease (NAFLD) because of chronic inflammation and insulin resistance. Several epidemiologic studies attempting to determine this risk have yielded inconsistent results. This meta-analysis was conducted with the aims to summarize all available evidence and estimate the risk of NAFLD in patients with H...
January 17, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28059940/histologic-tumor-grade-and-preoperative-bilary-drainage-are-the-unique-independent-prognostic-factors-of-survival-in-pancreatic-ductal-adenocarcinoma-patients-after-pancreaticoduodenectomy
#15
Nicolás Macías, José M Sayagués, Carmen Esteban, Manuel Iglesias, Luís M González, Jose Quiñones-Sampedro, María L Gutiérrez, Luís A Corchete, Maria M Abad, Oscar Bengoechea, Luís Muñoz-Bellvis
BACKGROUND AND AIM: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer; most patients die during the first 6 months after diagnosis. With a 5% 5-year survival rate, is the fourth leading cause of cancer death in developed countries. In this regard, several clinical, histopathologic and biological characteristics of the disease favoring long-term survival after pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite the availability of this information, there is no consensus about the different prognostic factors reported in the literature, probably due to variations in patient selection, methods, and sample size studied...
January 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28067753/long-term-extent-change-of-pediatric-onset-ulcerative-colitis
#16
Firas Rinawi, Amit Assa, Corina Hartman, Yael Mozer Glassberg, Vered Nachmias Friedler, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
BACKGROUND: Data describing extent change (progression or regression) in pediatric-onset ulcerative colitis (UC) are scarce. GOAL: We aimed to describe extent change in pediatric-onset UC during long-term follow-up and to assess predictors of extent change. STUDY: Medical charts of pediatric-onset UC patients with at least 5-year follow-up were analyzed retrospectively. Disease extent was determined using the Paris classification. It was examined at diagnosis and during follow-up at different time points...
January 6, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28059943/efficacy-safety-and-outcomes-of-endoscopic-retrograde-cholangiopancreatography-with-per-oral-pancreatoscopy-a-multicenter-experience
#17
Sheeva K Parbhu, Ali A Siddiqui, Megan Murphy, Arish Noor, Linda J Taylor, Alyssa Mills, Douglas G Adler
INTRODUCTION: Per-oral pancreatoscopy can be used for both evaluation and treatment of pancreatic duct stones during endoscopic retrograde cholangiopancreatography, evaluating and treating pancreatic duct strictures of indeterminate etiology, and visual inspection and direct biopsy of pancreatic duct mucosa for diagnosis of intraductal papillary mucinous neoplasm (IPMN). We aim to describe the efficacy, safety, and outcomes of pancreatoscopy in a large, multicenter series of patients...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28059942/efficacy-of-biofeedback-therapy-in-the-treatment-of-dyssynergic-defecation-in-community-dwelling-elderly-women
#18
Miguel A Simón, Ana M Bueno
AIM OF THE STUDY: The aim of this study was to evaluate the efficacy of biofeedback therapy in the treatment of dyssynergic defecation in chronically constipated community-dwelling elderly women. MATERIALS AND METHODS: After an initial assessment phase carried out during 1 month, 20 chronically constipated women with dyssynergic defecation were randomly assigned to either electromyographic biofeedback (EMG-BF) group (n=10) or control group (n=10). Outcome measures used to evaluate the efficacy of treatment were weekly stool frequency, sensation of incomplete evacuation, difficulty evacuation level, mean EMG-activity (μV) of the external anal sphincter during straining to defecate and Anismus index...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28059941/adenoma-detection-rates-for-screening-colonoscopies-in-smokers-and-obese-adults-data-from-the-new-hampshire-colonoscopy-registry
#19
Joseph C Anderson, Julia E Weiss, Christina M Robinson, Lynn F Butterly
GOAL: To examine screening adenoma detection rates (ADR) and serrated detection rates (SDR) among smokers and obese adults in the New Hampshire Colonoscopy Registry. BACKGROUND: ADR, a quality measure for screening colonoscopies, is associated with protection from interval colorectal cancer. Currently, only sex-specific ADR benchmarks are reported. However, obesity and smoking ≥20 pack-years are strong predictors for colorectal neoplasia, as highlighted by the 2009 American College of Gastroenterology CRC Screening Guidelines...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28059939/endoscopic-stenting-for-colorectal-cancer-lessons-learned-from-a-15-year-experience
#20
Enrico Fiori, Antonietta Lamazza, Antonio V Sterpetti, Alberto Schillaci
GOAL: The aim of our prospective study was to analyze the results of endoscopic stenting to treat obstruction due to colorectal cancer and complications after colorectal resection for cancer. BACKGROUND: Endoscopic stenting for obstructing colorectal cancer has become a common place in clinical practice. However, there is a 2% to 5% risk of bowel perforation, and a percentage of technical failure of 2% to 10%. MATERIALS AND METHODS: In a 15-year period (August, 1999 to December, 2013), 153 patients with colorectal cancer had endoscopic placement of a self-expandable metal stent for treatment of an obstructing colorectal cancer (133 patients) or for treatment of complications after colorectal resection for cancer (20 patients)...
January 5, 2017: Journal of Clinical Gastroenterology
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