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Immunology Letters

Seema Singh, S K Verma, Santosh Kumar, M K Ahmad, Anuradha Nischal, S K Singh, R K Dixit
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements...
January 9, 2018: Immunology Letters
Daniela Recabarren-Leiva, Marcelo Alarcón
The Flow Cytometry is the principal method used to measure platelet-derived microparticles (PDMPs), by fluorescent properties analysis. PDMPs (0.1-1.0 microns) are abundant in circulation, accounting for approximately 90% of the microparticles and are associated with Cardiovascular Disease, the leading cause of death in the world.
January 9, 2018: Immunology Letters
Mansi Bhatt, Surendra Kumar, Mohammad Haris Siddiqui, Naveen Garg, Balraj Mittal
RHD is an inflammatory disease resulting from interactive immune, genetic, and environmental factors. Various, epidemiological studies have shown the association of genetic variants of cytokine genes with a predisposition to RHD. However, the results from different populations are inconsistent. Therefore, we carried out a meta- analysis of twenty-three published case-control studies and the results indicated that TGF-β1 +869 T/C (T vs. C: OR = 7.68, 95% CI = 1.62-36.50; TT + CT vs. CC OR = 1...
January 6, 2018: Immunology Letters
Ayumi Yoshizaki
Systemic sclerosis (SSc) is a collagen disease characterized by autoimmunity and excessive extracellular matrix deposition in the skin and visceral organs. Although the pathogenic relationship between systemic autoimmunity and the clinical manifestations of SSc remains unknown, SSc patients show a variety of abnormal immune activation including the production of disease-specific autoantibodies and cytokine production. Many recent studies have demonstrated that immune cells, including T cells, B cells, and macrophages, have a variety of immunological abnormalities in SSc...
January 5, 2018: Immunology Letters
Babak Afkari, Zohreh Babaloo, Sanam Dolati, Alireza Khabazi, Farhad Jadidi-Niaragh, Mahsa Talei, Dariush Shanehbandi, Shiva Mahmoudi, Bita Hazhirkarzar, Ebrahim Sakhinia
BACKGROUND: Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups...
December 30, 2017: Immunology Letters
Davide Montin, Francesco Licciardi, Elisa Giorgio, Andrea Ciolfi, Simone Pizzi, Alessandro Mussa, Raffaella Meazza, Marco Tartaglia, Alfredo Brusco, Daniela Pende, Giovanni Battista Ferrero
No abstract text is available yet for this article.
December 23, 2017: Immunology Letters
Renata Cristina Messores Rudolf-Oliveira, Mariangeles Auat, Chandra Chiappin Cardoso, Iris Mattos Santos-Pirath, Barbara Gil Lange, Jéssica Pires-Silva, Ana Carolina Rabello de Moraes, Gisele Cristina Dametto, Mayara Marin Pirolli, Maria Daniela Holthausen Périco Colombo, Maria Claudia Santos-Silva
In 2010, new monoclonal antibodies were submitted to the 9th International Workshop on Human Leukocyte Differentiation Antigens, and there are few studies demonstrating normal expression patterns of these markers. Thus, the objective of this study was to determine the normal patterns of cell expression of CD86, CD210a, CD261, CD262, CD264, CD358, and CD361 in peripheral blood (PB) and bone marrow (BM) samples by flow cytometry. In the present study, CD86 was expressed only in monocytes and B lymphocytes in PB and in monocytes and plasma cells in BM...
December 21, 2017: Immunology Letters
Fatemeh Motevalli, Azam Bolhassani, Shilan Hesami, Sepideh Shahbazi
Macromolecules including DNA and proteins serve as important human therapeutics but are limited by their general inability to cross cell membranes. Supercharged proteins have been known as potent tools for delivery of macromolecules into mammalian cells. Thus, the use of these delivery systems is important to reduce the human papillomavirus (HPV)-associated malignancies through improvement of vaccine modalities. In this study, we used a supercharged green fluorescent protein (+36 GFP) for delivery of the full-length HPV16 E7 DNA and protein into mammalian cells and evaluated immune responses, and protective/therapeutic effects of different formulations in C57BL/6 tumor mice model...
December 19, 2017: Immunology Letters
Haruka Mizobuchi, Wataru Fujii, Kanna Ishizuka, Yihan Wang, Sayoko Watanabe, Chizu Sanjoba, Yoshitsugu Matsumoto, Yasuyuki Goto
Myeloid-related protein (MRP) 14 and MRP8 are abundantly expressed by myeloid cells and are involved in various inflammatory disorders. Although accumulating evidence revealed the roles of MRP14 and MRP8 in inflammatory responses by using MRP14-knockout (KO) mice, the KO mice were only available in the C57BL/6 background. We established BALB/c-background MRP14-KO mice to examine if its biological functions are conserved in mice with a different genetic background. MRP14-KO BALB/c mice showed different phenotypes from the reported MRP14-KO C57BL/6 mice in terms of bone marrow cell response to LPS and peripheral leukocyte population...
December 15, 2017: Immunology Letters
Yukihide Matsui, Taku Kuwabara, Toyonobu Eguchi, Koichi Nakajima, Motonari Kondo
T cell functions are regulated by multiple signaling cascades, including the MKK4-JNK (c-Jun NH2 terminal kinase) pathway. However, the mechanism regulating the MKK4-JNK axis in T cells remains unclear. Herein, we demonstrated that protein acetylation modulates JNK activity induced by T cell receptor (TCR) activation. The acetyltransferase, CREB-binding protein (CBP), is transported from the nucleus to the cytoplasm in response to TCR cross-linking. To investigate the role of CBP in TCR signaling, we overexpressed CBP in the cytoplasm of Jurkat cells, a human T lymphocyte line...
December 14, 2017: Immunology Letters
Alvaro Brittoli, Silvia Fallarini, Hao Zhang, Roland J Pieters, Grazia Lombardi
Galectin-3 (Gal-3) is a β-galactoside binding protein able to modulate both innate and adaptive immune responses. First identified in macrophages, Gal-3 has been studied widely in many mammalian immune cells, but scarcely in natural killer (NK) cells. The aim of this study was to analyze Gal-3 in human NK cells, isolated from peripheral blood mononuclear cells. Both PCR and RT-PCR analysis showed that resting human NK cells express Gal-3 mRNA, which can be modulated upon cytokine stimulation (100 U/ml IL-2 + 20 ng/ml IL-15) for different period of time (1-24 h)...
December 14, 2017: Immunology Letters
Jamie King, David Abraham, Richard Stratton
No abstract text is available yet for this article.
December 13, 2017: Immunology Letters
Carol M Artlett
Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation in collagen synthesis, leading to the increased deposition of collagens, primarily type I and III, and the deposition of other extracellular matrix proteins in the skin and internal organs, in a mechanism that is thought to be an over active wound healing process. These patients experience significant morbidity and the mortality rate in this disease is high. Indeed, scleroderma is the most deadly of diseases in the autoimmune spectrum...
December 4, 2017: Immunology Letters
Donato Rigante
The protean clinical phenotypes of hereditary autoinflammatory disorders (HAID) are caused by abnormal activation of innate immunity and consist of seemingly unprovoked inflammatory flares localized to multiple organs, such as the skin, joints, serosal membranes, gut, and central nervous system. Different mutations in genes implied in activation of the interleukin-1 (IL-1)-structured inflammasome, cytoskeletal signaling and apoptosis contribute to the pathogenesis of different HAID, which mostly start in childhood with self-limited flares unrelated to infectious agents, autoantibody production or autoreactive cells...
December 1, 2017: Immunology Letters
Qianying Lv, Chao Li, Yarui Mo, Long He
There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of heart allograft rejection. The high-mobility group box (HMGB) proteins, particularly HMGB1, are self-derived innate immune activators that have multiple functions in the regulation of immunity and inflammation...
November 30, 2017: Immunology Letters
Ramiah D Jacks, Taylor J Keller, Alexander Nelson, Michael Nishimura, Paula White, Makio Iwashima
It has been generally considered that the perinatal immune system is less inflammatory compared to the adult system and type 2 responses predominate perinatal immune responses against antigens. Indeed, previous studies in mice showed that there are cell-intrinsic differences between neonatal and adult CD4T cells. However, studies on human cord blood and infant blood demonstrated that human perinatal T cells do not produce elevated levels of Th2 cytokines with the exception of IL-13. These data raise the question if human T cells in the perinatal blood fundamentally differ from adult T cells...
November 24, 2017: Immunology Letters
Boris Tchernychev, Talia Miron, Meir Wilchek
Human serum contains natural antibodies against avidin. Affinity purified natural anti-avidin human IgG exhibits affinity constants comparable to those of antibodies produced by active immunization of rabbits. Using a random hexapeptide library displayed on the filamentous M13 phage, and rabbit anti-avidin purified antibodies as a selector, we searched for epitopes shared by both selector and natural human anti-avidin IgG. This approach, enabled the isolation and identification of phagotopes bearing consensus motifs similar to sequence stretches of the avidin loops and β-sheet regions...
November 22, 2017: Immunology Letters
Hadi Hassannia, Mohammad Mehdi Amiri, Farhad Jadidi-Niaragh, Reza Hosseini-Ghatar, Jalal Khoshnoodi, Ramezan-Ali Sharifian, Forough Golsaz-Shirazi, Mahmood Jeddi-Tehrani, Fazel Shokri
INTRODUCTION: Immunotherapy with tumor-associated antigens (TAAs) is a potentially powerful approach to eradicate tumor cells. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) plays a crucial role for survival of tumor cells and is overexpressed in various malignancies. In the present study, we developed a syngeneic mouse tumor model to assess anti-tumor effect of mouse ROR1 specific polyclonal antibody (pAb) in vivo. MATERIALS AND METHODS: Mouse ROR1 specific antibody was produced in rabbit using recombinant ROR1 protein...
November 22, 2017: Immunology Letters
Massume Abolhasani, Mohammad Ali Rezaee, Mehdi Mohammadi, Tayyeb Ghadimi, Mobin Mohammadi, Mohammad Reza Rahmani
In vivo and In vitro ages of the mesenchymal stromal cells (MSCs) affects their features. We investigated immunomodulatory properties of the term and preterm human umbilical cord vein (UCV) MSCs at the passages (P) 2 and 5. Term and preterm UCV-MSCs at P2 and 5 were co-cultured with two-way mixed lymphocyte reaction. The proliferation, IFN-γ and IL-10 levels, and mRNA levels of the COX-2, TGF-β1, TNF-α, IL-4 and FoxP3 were assessed. The term UCV-MSCs and P5 have a stronger inhibitory effects on proliferation than preterm UCV-MSC and P2, respectively (P=0...
November 22, 2017: Immunology Letters
Jitka Fucikova, Lenka Kasikova, Iva Truxova, Jan Laco, Petr Skapa, Ales Ryska, Radek Spisek
The death of cancer cells can be categorized as either immunogenic (ICD) or nonimmunogenic, depending on the initiating stimulus. The immunogenic processes of immunogenic cell death are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface exposure of calreticulin (CRT), secretion of adenosine triphosphate (ATP), release of non-histone chromatin protein high-mobility group box 1 (HMGB1) and the production of type I interferons (IFNs). DAMPs are recognized by various receptors that are expressed by antigen-presenting cells (APCs) and potentiate the presentation of tumor antigens to T lymphocytes...
November 22, 2017: Immunology Letters
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