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Immunology Letters

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https://www.readbyqxmd.com/read/28087292/loss-of-cd28-within-cd4-t-cell-subsets-from-cervical-cancer-patients-is-accompanied-by-the-acquisition-of-intracellular-perforin-and-is-further-enhanced-by-nkg2d-expression
#1
Marta Escarra-Senmarti, Miriam Ruth Bueno-Topete, Luis Felipe Jave-Suarez, Eduardo Gomez-Bañuelos, Jorge Gutierrez-Franco, Natali Vega-Magaña, Adriana Aguilar-Lemarroy, Ana Laura Pereira-Suarez, Jesse Haramati, Susana Del Toro-Arreola
CD28 is well characterized as an essential co-stimulatory receptor critical for activation, proliferation and survival processes in CD4(+) T cells. Populations of CD4(+)CD28(null) T cells, with apparently contradictory physiological roles, have recently been reported, along with the co-expression of the NK activating receptor NKG2D, in autoimmune diseases and chronic viral inflammation. Paradoxically, studies in cancer suggest that an expanded CD4(+)NKG2D(+) population may be armed with immunosuppressive properties...
January 10, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28082134/the-dual-role-of-cathelicidins-in-systemic-inflammation
#2
LETTER
Fabiano Pinheiro da Silva, Marcel Cerqueira César Machado
Antimicrobial peptides are key components of the innate immune system. They act as broad-spectrum antimicrobial agents against Gram-positive and -negative bacteria, viruses, and fungi. More recently, antimicrobial peptides have been ascribed immunomodulatory functions, including roles in wound healing, induction of cytokines, and altering host gene expression. Cathelicidins are a class of antimicrobial peptide found in humans, mice, and rats, among others. Known as LL-37 in humans and cathelin-related antimicrobial peptide (CRAMP) in rodents, cathelicidins are produced by many different cells, including macrophages, neutrophils, and epithelial cells...
January 9, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28069488/mesenchymal-stem-cells-increase-skin-graft-survival-time-and-up-regulate-pd-l1-expression-in-splenocytes-of-mice
#3
Ali Moravej, Bita Geramizadeh, Negar Azarpira, Amir-Hasan Zarnani, Ramin Yaghobi, Mehdi Kalani, Maryam Khosravi, Amin Kouhpayeh, Mohammad-Hossein Karimi
Recently, mesenchymal stem cells (MSCs) have gained considerable interests as hopeful therapeutic cells in transplantation due to their immunoregulatory functions. But exact mechanisms underlying MSCs immunoregulatory function is not fully understood. Herein, in addition to investigate the ability of MSCs to prolong graft survival time, the effects of them on the expression of PD-L1 and IDO immunomodulatory molecules in splenocytes of skin graft recipient mice was clarified. To achieve this goal, full-thickness skins were transplanted from C57BL/6 to BALB/c mice...
January 6, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28065603/retinoic-acid-induces-hypersegmentation-and-enhances-cytotoxicity-of-neutrophils-against-cancer-cells
#4
Sanjeeb Shrestha, Shin-Yeong Kim, Young-Jin Yun, Jun-Kyu Kim, Jae Man Lee, Minsang Shin, Dong-Keun Song, Chang-Won Hong
Hypersegmentation of nuclei is considered a distinct characteristic of the antitumoral phenotype of neutrophils. Retinoic acid, a metabolite of retinol, reorganizes and induces segmentation of the nucleus during the differentiation of neutrophils. However, the role of retinoic acid in the phenotype polarization of neutrophils has not been fully established. Here, we investigated the effect of retinoic acid on phenotype polarization of neutrophils. Retinoic acid-induced the hypersegmentation of human neutrophils via retinoic acid receptors and mTOR pathways...
January 5, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28063891/gm-csf-and-il-4-produced-by-nkt-cells-inversely-regulate-il-1%C3%AE-production-by-macrophages
#5
Sehee Ahn, Dongjin Jeong, Sae Jin Oh, Jiye Ahn, Seung Hyo Lee, Doo Hyun Chung
Natural Killer T (NKT) cells are distinct T cell subset that link innate and adaptive immune responses. IL-1β, produced by various immune cells, plays a key role in the regulation of innate immunity in vivo. However, it is unclear whether NKT cells regulate IL-1β production by macrophages. To address this, we co-cultured NKT cells and peritoneal macrophages in the presence of TCR stimulation and inflammasome activators. Among cytokines secreted from NKT cells, GM-CSF enhanced IL-1β production by macrophages via regulating LPS-mediated pro-IL-1β expression and NLRP3-dependent inflammasome activation, whereas IL-4 enhanced M2-differentiation of macrophages and decreased IL-1β production...
January 4, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28062218/mirna-144-induces-microglial-autophagy-and-inflammation-following-intracerebral-hemorrhage
#6
Anyong Yu, Tianxi Zhang, Wenyi Zhong, Haizhen Duan, Song Wang, Peng Ye, Juan Wang, Shanchuan Zhong, Zhao Yang
Autophagic activation mediated inflammation contributes to brain injury of intracerebral hemorrhage (ICH). MiRNAs play a key role in inflammation, which negatively and posttranscriptionally regulate gene expression and function. Modulating the mTOR signal, a central regulator of autophagy, could be of great significance for ICH. However, the specific of miRNA is unknown. In the current study, we detected the miRNA-144 expression, autophagic activity and inflammation of microglia in ICH. We also knocked down endogenous miRNA-144 to regulate autophagy and inflammation in ICH...
January 3, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28025044/a-dual-label-time-resolved-fluorescence-immunoassay-trfia-for-screening-of-coronary-atherosclerosis-based-on-simultaneous-detection-of-lp-pla2-and-hscrp
#7
Zhong Zhang, Xiaozhu Liu, Yinfeng Li, Ruolan Huang, Ling Wang, Laiqing Li, Cuicui Chen, Lijun Ou, Xiao Chang, Qiujie Qiao, Mingtai Chen
Atherosclerosis is the underlying cause of most coronary events. The conventional method for coronary atherosclerosis detection is morphological examination or coronary arterionyraphy. These methods are complex and time-consuming. In this study a two-step dual-label TRFIA was developed for the simultaneous detection of Lp-PLA2 and hsCRP in a single run. The performance of this assay was first evaluated using clinical serum samples, and then compared with commercialized kits. The sensitivity of this assay for Lp-PLA2 detection was 1ng/mL (dynamic range, 0-1000U/L), and the sensitivity for hsCRP detection was 1mg/L (dynamic range, 1-1000mg/L)...
December 23, 2016: Immunology Letters
https://www.readbyqxmd.com/read/28025043/mir-124-contributes-to-m2-polarization-of-microglia-and-confers-brain-inflammatory-protection-via-the-c-ebp-%C3%AE-pathway-in-intracerebral-hemorrhage
#8
Anyong Yu, Tianxi Zhang, Haizhen Duan, Yong Pan, Xiaojun Zhang, Guang Yang, Juan Wang, Yi Deng, Zhao Yang
Microglia mediated inflammation contributes to intracerebral hemorrhage (ICH) induced secondary injury. Activated microglia has dual functions as pro-inflammatory (M1) and anti-inflammatory (M2) factors in brain injury and repair. MiR-124 is a potent anti-inflammatory agent which affects microglia after brain injury. However, the potential of modulating the M1/M2 polarization of microglia after ICH has not been reported. In this experiment, we detected the effect of miR-124 on the M1/M2 polarization state. In addition, the ability miR-124 to subsequently impacted neurological deficit and cerebral water content of ICH mice were studied...
December 23, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27939191/an-elevated-pro-inflammatory-cytokines-profile-in-behcet-s-disease-a-multiplex-analysis
#9
Nasser Gholijani, Mohammad Reza Ataollahi, Afshin Samiei, Elham Aflaki, Saeedeh Shenavandeh, EskandarKamali-Sarvestani
The serum levels of sixteen cytokines related to innate immunity, Th1, Th2 and Th17 cells in the sera of 44 patients with Behcet's Disease (BD) and 44 healthy controls have been investigated using the cytokine array technique. Among the cytokines related to innate immunity, the levels of IL-1α, IL-1 β, IL-6, IL-12, IL-15 and TNF-α were statistically higher in BD patients than healthy controls. In the case of Th1- and Th17-related cytokines, IL-2, IFN-γ, IL-17 and IL-23 were significantly higher in patients...
December 6, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27923569/gender-differences-of-b-cell-signature-related-to-estrogen-induced-ifi44l-baff-in-systemic-lupus-erythematosus
#10
Hongye Fan, Guangfeng Zhao, Deshan Ren, Fei Liu, Guanjun Dong, Yayi Hou
Systemic lupus erythematosus (SLE) possesses a gender-dependent incidence characterized by a male/female ratio 1:9. B-cell, a vital part of the immune system, plays an important role in pathogenesis of SLE. Thus, we hypothesize that gender differences of B cells may exist in SLE and relate to the onset and the progression of SLE. Here, we showed that the genes expression pattern is similar between healthy female and male. However, SLE female and SLE male showed more upregulated genes, in which the trendline of SLE male is higher than that of SLE female...
December 5, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27919749/in-vitro-vla-4-blockade-results-in-an-impaired-nk-cell-mediated-immune-surveillance-against-melanoma
#11
Ilaria Gandoglia, Federico Ivaldi, Paolo Carrega, Eric Armentani, Guido Ferlazzo, Gianluigi Mancardi, Nicole Kerlero de Rosbo, Antonio Uccelli, Alice Laroni
Natalizumab (NTZ) is a monoclonal antibody targeting the α4β1 integrin (CD49d/CD29), very late antigen-4 (VLA-4), which is approved for treatment of relapsing-remitting multiple sclerosis (RR-MS). A possible association between NTZ treatment and a higher risk of melanoma is under debate. Natural Killer (NK) cells, which express VLA-4, represent an innate barrier limiting spreading of melanoma under steady state conditions. Indeed, because of their expression of activating receptors, they are very efficient in recognizing and killing melanoma cells without the need of a previous priming...
December 2, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27919748/anti-cd24-neutralizing-antibody-exacerbates-concanavalin-a-induced-acute-liver-injury-in-mice-via-liver-m1-macrophages
#12
Hongyu Liu, Lei Hai, Jingqi Tian, Jie Xiang, Yatong Fan, Hua Zhang, Jianhui Liu, Xuejun Zhang
Liver largely relies on its innate immunity to initiate quick and effective defense against potentially toxic agents, and innate immune cells are major players in this process. However, excessive inflammation due to out-of-control immune response may eventually cause liver injury. Thus, it is important to fully understand the regulatory mechanisms associated with liver inflammation. Here we showed that anti-CD24 neutralizing antibody exacerbated hepatic inflammation in a Con A-induced acute liver injury murine model...
December 2, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27916629/chitosan-nanoparticles-as-a-dual-drug-sirna-delivery-system-for-treatment-of-colorectal-cancer
#13
Sanam Sadreddini, Reza Safaralizadeh, Behzad Baradaran, Leili Aghebati-Maleki, Mohammad Ali Hosseinpour-Feizi, Dariush Shanehbandi, Farhad Jadidi-Niaragh, Sevil Sadreddini, Hossein Samadi Kafil, Vahid Younesi, Mehdi Yousefi
Nanoparticles are widely used to deliver anticancer drugs and inhibit tumor growth without systemic toxicity. Recently, chitosan has received much attention as a functional biopolymer for encapsulation of small interfering RNA (siRNA). Because of cationic nature, chitosan efficiently encapsulate siRNA and forming nanoparticles. Moreover, biocompatible and biodegradable properties represent chitosan as potential candidate for in vivo siRNA delivery. In the present study we designed carboxymethyl dextran (CMD) chitosan nanoparticles (ChNPs) to encapsulate snail siRNA and anticancer drug doxorubicin (DOX)...
December 1, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27899275/immunological-consequences-of-immunization-with-tumor-lysate-vaccine-and-propranolol-as-an-adjuvant-a-study-on-cytokine-profiles-in-breast-tumor-microenvironment
#14
Somayeh Ashrafi, Reza Shapouri, Mehdi Mahdavi
In this study, we sought out to study the anti-cancer effects of propranolol (Pro) in combination with tumor lysate vaccine on lymphocyte proliferation activities as well as on IL-2, IL-4, IL-10, IL-12, IL-17 and IFN-γ cytokine concentration in the tumor microenvironment (TME). A tumor model was established in inbred Balb/C mice using transplantation of tumor to the flank of native mice. Tumor-bearing mice were immunized with lysate tumor cells (vaccine), a combination of Pro/Vaccine (Vac). Control groups consisted of tumor-bearing mice receiving only propranolol or PBS three times with one week interval via subcutaneous (s...
November 27, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27889626/absence-of-kynurenine-3-monooxygenase-reduces-mortality-of-acute-viral-myocarditis-in-mice
#15
Hisako Kubo, Masato Hoshi, Akihiro Mouri, Chieko Tashita, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito
Infection of the encephalomyocarditis virus (EMCV) in mice is an established model for viral myocarditis. Previously, we have demonstrated that indoleamine 2,3-dioxygenase (IDO), an L-tryptophan - kynurenine pathway (KP) enzyme, affects acute viral myocarditis. However, the roles of KP metabolites in EMCV infection remain unclear. Kynurenine 3-monooxygenase (KMO) is one of the key regulatory enzymes, which metabolizes kynurenine to 3-hydroxykynurenine in the KP. Therefore, we examined the role of KMO in acute viral infection by comparing between KMO(-/-) mice and KMO(+/+) mice...
November 24, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27876525/il-6-roles-molecular-pathway-and-clinical-implication-in-pancreatic-cancer-a-systemic-review
#16
REVIEW
Vlad-Vasile Pop, Andrada Seicean, Iulia Lupan, Gabriel Samasca, Claudia-Cristina Burz
Pancreatic cancer has attracted a great deal of attention owing to the poor outcome, increasing prevalence in the last years and delay diagnosis. Known as a complex disease, it involves genetic mutations, changes in tumour microenvironment and inflammatory component dominated by interleukin-6 and its activated pathways, like Janus Kinase-Signal Transducer and Activator of Translation3, Mitogen Activated Protein Kinase and Androgen receptor. The pro-inflammatory cytokine, plays a central role in oncogenesis, cancer progression, invasiveness, microenvironment changes, treatment resistance, prognosis and associated co morbidities like cachexia and depression...
November 19, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27867030/gemcitabine-treatment-enhanced-the-anti-tumor-effect-of-cytokine-induced-killer-cells-by-depletion-of-cd4-cd25-bri-regulatory-t-cells
#17
Peng Zhao, Danni Zhu, Zhen Zhang, Bin Han, Daiqing Gao, Xiaofang Wei, Xihe Xie, Changyou Li, Weihong Sun, Qingqing Wang, Qingming Guo
Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4(+)CD25(bri) regulatory T cells can be also induced by high dose of interleukin 2 (IL-2) which is used for CIK cells amplification in the CIK cell culture system, the anti-tumor activity of CIK cells was suppressed to some extent...
November 17, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27845152/development-of-an-indirect-immunofluorescence-based-assay-for-diagnosis-of-ulcerative-colitis-in-indian-population
#18
Allan V Rodrigues, Chander P Puri, Paresh B Bhanushali, Kunal K Shukla, Sampurna Roychoudhury, Shamkant B Badgujar
The prevalence of Ulcerative Colitis (UC), once thought to be negligible, has increases exponentially in the Indian population. The development of novel, cost effective and time efficient Indirect Immunofluorescence (IIF) based assay for detection of anti-neutrophil cytoplasmic antibodies (ANCA) and diagnosis of UC in the Indian population is discussed. A novel IIF based assay was developed using intact nuclei from human neutrophils to detect atypical p-ANCA in patients suffering from UC. Sera from 45 patients diagnosed with UC, 45 healthy controls and one related disease control were tested using a novel UC-ANCA assay and validated by commercially available ANCA IIF assay...
November 11, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27840176/crem-variant-rs17583959-conferred-susceptibility-to-t1d-risk-in-the-tunisian-families
#19
Ferjani Zouidi, D Bouzid, H Fourati, R Fakhfakh, T Kammoun, M Hachicha, C Penha-Gonçalves, H Masmoudi
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease caused by the destruction of insulin-producing pancreatic β-cells by autoreactive T cells. Studies in animal models, such as the non-obese diabetic (NOD) mouse reveal that this disease is under the control of several genes that encode molecules implicated in regulation of transcription factors and in T cell activation. In order to underline the role of the genes involved in this regulation pathways, we investigated, using the Sequenom MassARRAY platform, 13 single-nucleotide polymorphisms (SNPs) belonging to CREM, IRF5, STAT4, and STAT5a/b genes in 59 T1D Tunisian families...
November 10, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27838468/lipid-mediators-foster-the-differentiation-of-t-follicular-helper-cells
#20
Tomonori Nagaya, Koji Kawata, Ryuta Kamekura, Sumito Jitsukawa, Terufumi Kubo, Motonari Kamei, Noriko Ogasawara, Ken-Ichi Takano, Tetsuo Himi, Shingo Ichimiya
Lipid mediators such as leukotrienes and lipoxines broadly regulate innate and acquired immunity, and their dysfunction causes various immune-mediated disorders. We previously reported a salient feature of arachidonate 5-lipoxyganase (Alox5), which is responsible for the production of such lipid mediators, in the regulation of high affinity antibodies in vivo. The aim of this study was to determine the functional significance of Alox5-related lipid mediators during the processes of acquired humoral responses...
November 10, 2016: Immunology Letters
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