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Immunology Letters

Farhad Babaie, Mehrdad Ebrazeh, Maryam Hemmatzadeh, Fatemeh Sadat Mohammadi, Arezoo Gowhari Shabgah, Mehrzad Hajaliloo, Ali Asghar Ebrahimi, Naghmeh Shirafkan, Gholamreza Azizi, Hamed Mohammadi, Zohreh Babaloo
BACKGROUND: Ankylosing spondylitis (AS) is a debilitating spondyloarthropathy that has been associated with variation in several genes. Human leukocyte antigen (HLA)-B27 constructs an impaired structure, culminating in recognition and activation of immune system. Impaired function of Endoplasmic reticulum aminopeptidase (ERAP) 1, which primes peptides to be loaded in HLA molecules, has strongly been associated with AS proneness. Here, we intended to investigate the possible association of ERAP1 gene single nucleotide polymorphisms (SNPs) with AS susceptibility in Iranian patients...
November 6, 2018: Immunology Letters
Se-Young Kim, Min-Jung Park, Jeong-Eun Kwon, Si-Young Choi, Hyeon-Beom Seo, Kyung Ah Jung, Jeong-Won Choi, Jin-Ah Baek, Han Hee Lee, Bo-In Lee, Sung-Hwan Park, Mi-La Cho
Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis factor α, interleukin (IL)-6, and interferon α by inhibiting Alu transcription; control of Ro60 mRNA expression may thus be therapeutically useful. However, few studies have evaluated the anti-inflammatory activity of Ro60...
November 2, 2018: Immunology Letters
Orso Maria Lucherini, Giuseppe Lopalco, Luca Cantarini, Giacomo Emmi, Antonio Lopalco, Vincenzo Venerito, Antonio Vitale, Florenzo Iannone
The current understandings on cellular and molecular biology suggest that Th17 axis plays a pivotal role in Behcet's disease (BD) pathogenesis. Recently the role of serum amyloid-A (SAA) as a potential marker of disease activity in BD patients has been explored, and it has been reported that the occurrence of specific clinical features are significantly associated with high serum levels of this inflammatory mediator. The aim of this study was to investigate the cytokine-like activity of SAA in inducing Th17 differentiation from CD4 + T naive cells in BD...
October 29, 2018: Immunology Letters
Negar Nowroozilarki, Hasan Halit Öz, Carolin Schroth, Andreas Hector, Bernd Nürnberg, Dominik Hartl, Saeed Kolahian
Asthma is a chronic inflammatory disease driven by overactivation of T helper cell type 2 (Th2) responses. In the present study, we investigated the functional relevance of CD11b+ Ly6G+ neutrophilic cells in allergic airway inflammation in vivo. Allergic airway inflammation in mice was induced by house dust mite (HDM) or ovalbumin (OVA) sensitization and challenge. CD11b+ Ly6G+ neutrophilic cells and T cell phenotypes were quantified by flow cytometry. To assess the functional in vivo relevance, CD11b+ Ly6G+ neutrophilic cells were adoptively transferred intravenously or intratracheally and consequences on airway inflammation were studied...
October 27, 2018: Immunology Letters
Justyna Sikora, Marta Smycz-Kubańska, Aleksandra Mielczarek-Palacz, Ilona Bednarek, Zdzisława Kondera-Anasz
PURPOSE: Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies of endometriosis. The aim of this study was to determine whether TGF-β could be involved in the pathogenesis of endometriosis. For this purpose, we evaluated concentrations of TGFβ1, TGF-β2, TGF-β3 and interleukin (IL)-1β, IL-6, IL-10, IL-17, IL-21 and IL-22 in peritoneal fluid (PF) and serum of women with endometriosis...
October 24, 2018: Immunology Letters
Sousan Kolahi, Mohammad-Jahed Farajzadeh, Shahriar Alipour, Alireza Abhari, Jafar Farhadi, Neda Bahavarnia, Aida Malek Mahdavi, Alireza Khabbazi, Ebrahim Sakhinia
INTRODUCTION: MicroRNAs (miRNAs) are involved in the pathogenesis of inflammatory diseases. MiR-146 and miR-155 emerged as key regulators of the immune response. This study designed to analyze the miR-146a and miR-155 expression in patients with Behcet's disease (BD) and investigated their association with the expression of tumor necrosis factor-alpha (TNF-α) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) genes. METHODOLOGY: In a case-control study, 47 Iranian Azeri BD patients and 61 age- and sex matched healthy controls recruited to the study...
October 23, 2018: Immunology Letters
Rodolfo Servín-Blanco, Rosa Mariana Chávaro-Ortiz, Rubén Zamora-Alvarado, Fernando Martínez-Cortes, Goar Gevorkian, Karen Manoutcharian
Although various immune checkpoint inhibitors (ICIs), used for the treatment of advanced cancer, showed remarkably durable tumor regression in a subset of patients, there are important limitations in a large group of non-responders, and the generation of novel immunogens capable of inducing protective cellular immune responses is a priority in cancer immunotherapy field. During the last decades, several types of vaccine immunogens have been used in numerous preclinical studies and clinical trials. However, although immunity to tumor Ags can be elicited by most vaccines tested, their clinical efficacy remains modest...
October 16, 2018: Immunology Letters
Karin Hufnagl, Erika Jensen-Jarolim
Vitamin A is an important micronutrient, from plants diet taken up as carotenoids, from animal food sources as retinol. Its active metabolite retinoic acid (RA) binds to nuclear hormone receptors, thereby regulating gene transcription programs in various cells. Adequate nutritional intake of vitamin A is essential for pre- and postnatal development, eyesight and reproduction, and it contributes to the maintenance and regulation of the immune system. Recent molecular studies indicate that lipocalins play an important role in the bioavailability of RA and its immune modulation against Th2 responses...
October 16, 2018: Immunology Letters
N Prajitha, S S Athira, P V Mohanan
Fever is one of the cardinal symptoms of onset of an infection or inflammation and is the common clinical indicator for medical consultation in mammalian host worldwide. Simply, fever manifested with elevation of body temperature from normal physiological range represents adaptive response of immune system on challenge with an infectious and non-infectious circumstance. Fever usually initiated in the periphery as a result of interaction of immune cells with exogenous or endogenous pyrogens. Peripheral pyrogenic signals gain access to the central nervous system via humoral and neural route...
October 15, 2018: Immunology Letters
Chaoqi Zhang, Yamin Qiao, Lan Huang, Feng Li, Zhen Zhang, Yu Ping, Zhibo Shen, Jingyao Lian, Feng Li, Lixuan Zhao, Yi Zhang
Skeletal muscle injury is a common symptom in daily life. After injury, a distinct population of regulatory T cells (Tregs) will infiltrate skeletal muscle in acute and chronic injury sites. However, the mechanism by which Tregs rapidly accumulate to the site of acute injury remains unclear. BALB/c mice were used to establish a cryo-injured model. Percentage of Tregs in the normal and cryo-injured tissues was detected on different days by flow cytometry. Then, the major factors that contribute to the repair of skeletal muscle by Tregs and the chemokines associated with the chemotaxis of Tregs in the paired muscle were analyzed by qRT-PCR...
October 12, 2018: Immunology Letters
Zhong-Yang Xu, Chao Zhou, Ke-Feng Zhang, Yan-Ping Zheng
Ankylosing spondylitis (AS) is a common form of seronegative spondyloarthritis. We had identified differentially expressed genes (DEGs) in AS based on our previous RNA-sequencing results. Our study aimed to identify key genes in AS by integrated microarray analysis. In this present study, we identified 1328 DEGs between AS and normal control by using integrated analysis of two datasets derived from the Gene Expression Omnibus (GEO) database. Functional annotation of DEGs were performed. Pathways in cancer, Pancreatic cancer and Natural killer cell mediated cytotoxicity were significantly enriched pathways for DEGs...
October 12, 2018: Immunology Letters
Pawel Karpinski, Pawel Skiba, Magdalena Kosinska, Marta Rosiek-Biegus, Emilia Królewicz, Nikolaus Blin, Eckart Meese, Bernard Panaszek, Marita Nittner-Marszalska, Maria Malgorzata Sasiadek
Background Insect venom immunotherapy (VIT) is used to protect patients against Hymenoptera insects' venom allergy (HVA), which can result in severe systemic or even life-threatening conditions. Molecular mechanisms triggered by VIT remain largely unknown. Objective To compare genome-wide gene expression of patients with severe HVA prior to VIT and 12 months after. Methods Whole blood RNA samples were analyzed on an expression array. Results from differential expression obtained on a microarray platform were confirmed by quantitative real -time PCR (qRT-PCR)...
October 10, 2018: Immunology Letters
Misa Vreca, Marina Andjelkovic, Natasa Tosic, Ana Zekovic, Nemanja Damjanov, Sonja Pavlovic, Vesna Spasovski
Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease with unknown etiology. Numerous studies have indicated that the disease heterogeneity implies various genetic abnormalities. Considering that SSc is characterized by a strong sex bias and that the position of IRAK1 gene is on the X chromosome, we assume that variations in IRAK1 gene could explain female predominance of SSc. It was previously described that miR-146a has a role in 'fine-tuning' regulation of the TLR/NF-kB signaling pathway through down-regulation of IRAK1 gene...
October 9, 2018: Immunology Letters
Jeremy Santamaria, Julie Darrigues, Joost P M van Meerwijk, Paola Romagnoli
Hematopoietic precursors entering the thymus undergo a maturation process leading to the generation of a variety of T cell subsets that migrate to the periphery to perform their effector functions. This maturation process is strictly regulated by multiple interactions of developing T cells with thymic stroma cells. Signals received via the T cell receptor for antigen, co-stimulatory molecules and cytokines will determine, through thymic selection and lineage choice, thymocyte-fate. Recently, different populations of peripheral antigen presenting cells and T cells have been reported to enter the thymus...
October 9, 2018: Immunology Letters
Vida Hashemi, Amir Salek Farrokhi, Asghar Tanomand, Zohreh Babaloo, Mohammad Hojjat-Farsangi, Enayat Anvari, Mohammad-Taher Tahoori, Rana Ezzeddini, Arezoo Hosseini, Tohid Gharibi, Ghasem Ghalamfarsa, Farhad Jadidi-Niaragh
Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly affects joints and characterized by chronic joint inflammation and infiltration of various immune cells in the synovium. Forkhead box P3 (Foxp3)-expressing regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and undesirable T cell responses. However, there are controversial reports regarding the defective function or frequency of these cells in various studies, which may be in part related to different polymorphisms of FoxP3 and influence of ethnicity on these differences...
October 4, 2018: Immunology Letters
Sara Carlotta Tagliacarne, Chiara Valsecchi, Marco Benazzo, Michele Nichelatti, Alessia Marseglia, Giorgio Ciprandi, Sergio Bernasconi
Respiratory infections, mainly in children, are a demanding challenge for physicians. Commonly, a relative immune-defect sustains their recurrence. At present, there is no standardized treatment for their prevention acting on the immune system. Citomix is a low-dose multicomponent medication largely used in this issue. The current study evaluated its ex vivo effect on adenoidal mononuclear cells recovered from children operated for adenoid hypertrophy. B cell phenotype, and IFN-γ, IL-6, IL-10, IgG, IgA, IgM in culture supernatants were evaluated...
September 25, 2018: Immunology Letters
Michaela Pribikova, Alena Moudra, Ondrej Stepanek
It is well established that lymphopenia induces the formation of the memory-phenotype T cells without the exposure to foreign antigens. More recently, the memory-phenotype antigen-inexperienced memory T cells were described in lymphoreplete mice and called virtual memory T cells. In this review, we compare multiple aspects of the biology of lymphopenia-induced memory T cells and virtual memory T cells, including cytokine requirements, the role of T-cell receptor specificity in the differentiation process, gene expression signature, and the immune response...
September 20, 2018: Immunology Letters
Se-Young Kim, Min-Jung Park, Jeong-Eun Kwon, Kyuong Ah Jung, Joo-Yeon Jhun, Seon-Yeong Lee, Hyeon-Beom Seo, Jae-Yoon Ryu, Jin-Ah Beak, Jong-Young Choi, Mi-La Cho
Cucurbitacin E (CuE) is a biochemical compound found in plants that are members of the family CuE has been studied for its roles in anti-inflammation and the inhibition of angiogenesis as well as for its properties as an antioxidant. CuE is a new agent that was identified as a selective inhibitor of the signal transducer and activator of transcription 3 (STAT3)-related pathway. STAT3, a pivotal transcription factor for Th17 differentiation, is critical for T cell alloactivation in acute graft-versus-host disease (aGvHD)...
September 18, 2018: Immunology Letters
A León-Flores, P M Del Río Estrada, L X Álvarez-García, E Piten-Isidro, G Reyes-Terán
Recent evidence has revealed that PD-L1 is expressed in two functional forms, namely, a membrane-bound form (mPD-L1) and a soluble form (sPD-L1). The identification of the soluble form of PD-L1 represents the discovery of a new potential mechanism for the activation of the PD-1 pathway that may mediate a physiological apoptotic mechanism through a cell-cell signalling-independent pathway and may also favour T cell dysfunction during HIV infection. Since the presence of sPD-L1 has not been well established in the scenario of chronic viral infection, we investigated the presence of sPD-L1 in the plasma of viraemic HIV+ individuals and the potential mechanism that promotes its production...
September 17, 2018: Immunology Letters
Ming-Horng Tsai, Chuen-Mao Yang, Kuo-Ting Chang, Chu-Chun Chuang, Wei-Ning Lin, Rong-San Jiang, Cheng-Hsun Wu, I-Ta Lee
Staphylococcus aureus (S. aureus) can often lead to many life-threatening diseases. It has the ability to invade normal endovascular tissue. Acute inflammation and its resolution are important to ensure bacterial clearance and limit tissue injury. Carbon monoxide (CO) has been shown to exert anti-inflammatory effects in various tissues and organ systems. In our study, we investigated the effects and the mechanisms of carbon monoxide releasing molecule-2 (CORM-2) on S. aureus-induced inflammatory responses in human aortic endothelial cells (HAECs)...
September 17, 2018: Immunology Letters
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