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Immunology Letters

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https://www.readbyqxmd.com/read/30653987/genetic-variants-of-smad2-3-4-7-are-associated-with-susceptibility-to-ulcerative-colitis-in-a-japanese-genetic-background
#1
Arisa Yamashita, Tatsuo Inamine, Shota Suzuki, Sayaka Fukuda, Miki Unoike, Yuka Kawafuchi, Haruhisa Machida, Hajime Isomoto, Kazuhiko Nakao, Kazuhiro Tsukamoto
PURPOSE: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is attributed to inappropriate inflammatory response in intestinal mucosa. Transforming growth factor β (TGF-β)/SMAD signaling plays key role in differentiation of naïve CD4+ T cells to T helper 17 (Th17) cells or regulatory T (Treg ) cells. This study aimed to investigate associations between single nucleotide polymorphisms (SNPs) of SMAD family genes and susceptibility to IBD in a Japanese cohort to elucidate genetic determinants of IBD...
January 14, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30639514/co-expression-of-membrane-bound-tnf-alpha-type-1-and-2-receptors-differ-in-the-subsets-of-immunocompetent-cells
#2
Sergey Sennikov, Alina Alshevskaya, Julia Zhukova, Irina Belomestnova, Aleksander Karaulov, Irina Evsegneeva, Julia Lopatnikova
The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Flow cytometry analysis was used to study whole populations as well as subsets (T regulatory cells, T memory cells, cytotoxic T cells, T helper cells)...
January 10, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30638737/corrigendum-to-ro60-inhibits-colonic-inflammation-and-fibrosis-in-a-mouse-model-of-dextran-sulfate-sodium-induced-colitis-immunol-lett-176-2016-81-89
#3
Se-Young Kim, Min-Jung Park, Jeong-Eun Kwon, Si-Young Choi, Hyeon-Beom Seo, Kyung Ah Jung, Jeong-Won Choi, Jin-Ah Baek, Han Hee Lee, Bo-In Lee, Sung-Hwan Park, Mi-La Cho
No abstract text is available yet for this article.
January 9, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30629982/notch-signaling-induces-lymphoproliferation-t-helper-cell-activation-and-th1-th2-differentiation-in-leprosy
#4
Bhavyata Dua, Rajni Upadhyay, Mohan Natarajan, Mamta Arora, Kithiganahalli Narayanaswamy Balaji, Beenu Joshi
The present study evaluates role of Notch1 signaling in the regulation of T cell immunity in leprosy. Peripheral blood mononuclear cells from leprosy patients and healthy controls were activated with Mycobacterium leprae antigens along with activation of Notch1 signaling pathway and then lymphoproliferation was analyzed by lymphocytes transformation test and the expression of Notch1 and its ligands DLL1, Jagged1 and Jagged 2, T cell activation marker and Th1-Th2 cytokines on Th cells in PBMCs of study subjects were analyzed by flow cytometry...
January 7, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30629981/the-multifaceted-role-of-notch-signal-in-regulating-t-cell-fate
#5
REVIEW
Shubhada V Chiplunkar, Dimpu Gogoi
Notch signaling pathway facilitates important cellular functions of the host. Notch signal is essential for the development of T cells, and the role of Notch in fine tuning of αβ versus γδ T cell lineage commitment is fundamentally different in mice and human. The Notch family of cell surface receptor likewise plays a critical role in regulating T cell activation, and influences T cell response both intrinsically and through the local environment. In this review, we take an overview of Notch signaling pathway and also emphasize the role of Notch signal in T cell lineage differentiation and activating effector function of peripheral T cells...
January 7, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30625342/haptoglobin-improves-acute-phase-response-and-endotoxin-tolerance-in-response-to-bacterial-lps
#6
Swathi M Raju, A Pawan Kumar, A Nichita Yadav, Karthik Rajkumar, Mvs Sandhya, Sandeepta Burgula
Sepsis is characterized by delayed acute phase response and lowered immune tolerance in patients. Acute phase serum proteins, like Haptoglobin (Hp), have been associated with increased mortality in bacteria mediated acute lung inflammation and sepsis in neonates. However, it's direct role in modulating the immune response by regulating pro-inflammatory mediators leading to immune tolerant state and if gender affects its expression levels during bacterial infection, especially in blood has not been fully explored...
January 6, 2019: Immunology Letters
https://www.readbyqxmd.com/read/30571996/distinctly-regulated-functions-and-mobilization-of-cd11c-positive-cells-elicited-by-tlr3-and-ips-1-signaling-in-the-cornea
#7
Mayumi Ueta, Junji Hamuro, Suzuko Ohsako, Shigeru Kinoshita
The human ocular surface epithelium expresses TLR3, which recognizes double-stranded (ds) RNA mimicking polyinosine-polycytidylic acid (polyI:C). Its stimulation induces the secretion of the inflammatory cytokines interleukin (IL)-6, IL-8, and type I interferon. The cytoplasmic helicase proteins RIG-I and MDA5 are also expressed on the ocular surface. We investigated the function of TLR3 in the cornea of CD11c- YFP+ and TLR3 KO CD11c- YFP+ mice. We also examined the function of IPS-1, an adaptor molecule common to RIG-I and/or MDA5, in IPS-1 KO CD11c- YFP+ mice...
December 17, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30550739/identification-and-immune-related-analysis-of-snps-in-litopenaeus-vannamei-toll3-receptor
#8
Wei Wang, Jude Juventus Aweya, Su Huimin, Xianliang Zhao, Mingqi Zhong, Yueling Zhang
Tolls and Toll-like receptors (TLRs), as innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, play a critical role in antimicrobial immune responses. Here, we report on single nucleotide polymorphisms (SNPs) of Litopenaeus vannamei Toll3 (LvToll3). Multiple sequence alignment of the L. vannamei Toll3 Leucine rich repeat C-terminal domain (LvToll3-LRR-CT) with other L. vannamei Tolls LRR-CT domains showed 39.23 % - 43.96 % homology at the nucleic acid level and 20...
December 11, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30543834/a-dual-role-of-tgf-%C3%AE-in-human-osteoclast-differentiation-mediated-by-smad1-versus-smad3-signaling
#9
Bitnara Lee, Younseo Oh, Sungsin Jo, Tae-Hwan Kim, Jong Dae Ji
TGF-β1 is highly expressed in the synovial tissue of patients with rheumatoid arthritis and is known as a cytokine that plays an important role in tissue repair and immune cell regulation. However, the role of TGF-β1 is still unclear in osteoclastogenesis. In this study, we examined the effect of TGF-β1 on osteoclast differentiation and the underlying mechanism using healthy human peripheral blood monocytes. TGF-β1 was found to inhibit osteoclast differentiation and decrease the expression of osteoclast-specific genes such as acid phosphatase 5, tartrate resistant and cathepsin K...
December 10, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30521839/soluble-mannose-receptor-levels-in-blood-correlate-to-disease-severity-in-patients-with-community-acquired-pneumonia
#10
Anne J M Loonen, Sandra Leijtens, Ozan Serin, Mirrian Hilbink, Peter C Wever, Adriaan J C van den Brule, Erik J M Toonen
PURPOSE: Community-acquired pneumonia (CAP) is the most common form of pneumonia and is a leading infectious cause worldwide. Identification of patients that are at risk to develop severe disease has proven to be a major challenge. Soluble mannose receptor (sMR; sCD206) is a new serum marker for macrophage activation. Recent studies showed that sMR levels are increased in patients suffering from severe infections making it a potential biomarker for improved discrimination of disease severity...
December 3, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30503823/impact-of-activated-invariant-natural-killer-t-cells-on-the-expansion-of-regulatory-t-cell-precursors-in-murine-thymocytes-in-vitro
#11
Haruki Katsumata, Masako Ikemiyagi, Toshihito Hirai, Taichi Kanzawa, Rumi Ishii, Satoshi Miyairi, Hironori Fukuda, Kan Saiga, Masayoshi Okumi, Yasuyuki Ishii, Takashi Yokoo, Kazunari Tanabe
Tolerance induction is a goal of clinical transplantation to prevent graft rejection without the lifelong use of immunosuppressive drugs. In a series of mouse studies, we previously reported that the establishment of mixed chimerism by treatment with a ligand for invariant natural killer T (iNKT) cells with CD40 signal blockade makes it possible to prevent allograft rejection without immunosuppressants, and this approach fails in thymectomized recipient mice. In this study, we showed that iNKT cells in murine thymocyte cultures are indispensable for the expansion of CD4+ CD25+ Foxp3+ regulatory T (Treg) cells as well as CD4+ CD25+ Foxp3- cells, which contained precursor Tregs (preTregs)...
November 29, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30503822/mir-181b-regulates-er-stress-induced-neuron-death-through-targeting-heat-shock-protein-a5-following-intracerebral-haemorrhage
#12
Zhenyu Wang, Liang Fang, Hui Shi, Zhao Yang
Endoplasmic reticulum (ER) stress acts as a protein folding and contributes to neuronal damage and neurological deterioration following intracerebral hemorrhage (ICH). Heat Shock Protein A5 (HSPA5) serves as an essential regulator of the endoplasmic reticulum (ER) stress response. However, the specific mechanism has not been will identified. Primary cortical neurons from C57BL/6 mice were subjected to erythrocyte lysates. Cell viability, microRNA and HSPA5 levels, and ER stress was detected. The interaction between microRNA and the target HSPA5 was identified by dual luciferase reporter gene assay...
November 29, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30503821/interaction-and-involvement-of-cellular-adhesion-molecules-in-the-pathogenesis-of-schistosomiasis-mansoni
#13
REVIEW
Vanessa Ribeiro Figliuolo da Paz, Daniel Figueiredo-Vanzan, Alexandre Dos Santos Pyrrho
Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. The presence of eggs in the tissue triggers the recruitment and activation of immune cells to wall off and isolate them from the rest of the organism...
November 29, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30496765/passive-immunotherapy-with-specific-igg-fraction-against-autolysin-analogous-protectivity-in-the-mrsa-infection-with-antibiotic-therapy
#14
Yasamin Kalali, Setareh Haghighat, Mehdi Mahdavi
Staphylococcus aureus is a leading infectious cause of life-threatening diseases in human beings, with no effective vaccine available to date against this bacterium. Treatment of methicillin-resistant S. aureus (MRSA) infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Immunotherapy represents a potential approach to prevent S. aureus-related infections. Autolysin is one of the virulence factors, which controls the growth, cell lysis, daughter-cell separation, and biofilm formation...
November 26, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30471320/anti-rheumatoid-arthritis-effects-in-adjuvant-induced-arthritis-in-rats-and-molecular-docking-studies-of-polygonum-orientale-l-extracts
#15
Kai-Jun Gou, Rui Zeng, Xiao-Dong Ren, Qi-Ling Dou, Qing-Bo Yang, Yan Dong, Yan Qu
BACKGROUND AND PURPOSE: Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively) had anti-inflammatory and analgesic effects in early research, which was mainly relevant to the existence of flavonoids. According to the clinical application of P. orientale in traditional Chinese medicine, it has long been used for rheumatic arthralgia and rheumatoid arthritis...
November 21, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30447309/functional-insights-into-nucleotide-metabolizing-ectoenzymes-expressed-by-bone-marrow-resident-cells-in-patients-with-multiple-myeloma
#16
REVIEW
A L Horenstein, F Morandi, C Bracci, V Pistoia, F Malavasi
Human myeloma cells grow in a hypoxic acidic niche in the bone marrow. Cross talk among cellular components of this closed niche generates extracellular adenosine, which promotes tumor cell survival. This is achieved through the binding of adenosine to purinergic receptors into complexes that function as an autocrine/paracrine signal factor with immune regulatory activities that i) down-regulate the functions of most immune effector cells and ii) enhance the activity of cells that suppress anti-tumor immune responses, thus facilitating the escape of malignant myeloma cells from immune surveillance...
November 15, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30447311/impact-of-the-gk-1-adjuvant-on-peritoneal-macrophages-gene-expression-and-phagocytosis
#17
L Sánchez-Hernández, L Montero, R Mojica-Espinosa, J P Reyes-Grajeda, J Cervantes-Torres, R M Parkhouse, G Fragoso, E Sciutto
PURPOSE: The synthetic peptide GK-1 potentiates protective immunity elicited by the influenza vaccine in mice. In order to understand its adjuvant properties, this study was designed to determine the impact of GK-1 on gene expression and phagocytosis of peritoneal macrophages (PMa). METHODS: Increased gene expression of chemokines involved in leukocyte recruitment and of pro-inflammatory mediators was detected by microarray analysis of control and GK-1 treated PMa macrophages...
November 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30447310/interleukin-33-gene-expression-and-rs1342326-polymorphism-in-beh%C3%A3-et-s-disease
#18
Mahsa Talei, Ali Abdi, Dariush Shanebandi, Farhad Jadidi-Niaragh, Alireza Khabazi, Farhad Babaie, Shahriar Alipour, Babak Afkari, Ebrahim Sakhinia, Zohreh Babaloo
OBJECTIVE: Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the current study, we investigated the association of IL-33 gene rs1342326 polymorphism and expression levels of this gene in peripheral blood mononuclear cells (PBMCs) with the susceptibility to BD in Azari population of Iran...
November 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30447308/designing-a-diagnostic-kit-for-oxalyl-coa-decarboxylase-enzyme-by-elisa-method
#19
Fatemeh Abarghooi Kahaki, Abbas Basiri, Mojgan Bandehpour, Bahram Kazemi
Urinary stones are the third most commonly reported urinary tract disease. Kidney stones are one of the most common types of urinary stones that most of them (70-80%) are calcium oxalate. Oxalic acid is highly oxidized organic compounds, which found in dietary and produced by the intestinal microflora. Oxalyl CoA decarboxylase is a key enzyme and plays an important role in oxalate degradation. In this study, the Oxalyl CoA decarboxylase gene which contains an -histidine tag was cloned in pET 28a (+) and expressed in Escherichia coli BL21 (DE3)...
November 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/30439479/human-natural-killer-cells-and-other-innate-lymphoid-cells-in-cancer-friends-or-foes
#20
REVIEW
Paola Vacca, Enrico Munari, Nicola Tumino, Francesca Moretta, Gabriella Pietra, Massimo Vitale, Genny Del Zotto, Francesca Romana Mariotti, Maria Cristina Mingari, Lorenzo Moretta
Innate lymphoid cells (ILC) including NK cells (cytotoxic) and the recently identified "helper" ILC1, ILC2 and ILC3, play an important role in innate defenses against pathogens. Notably, they mirror analogous T cell subsets, regarding the pattern of cytokine produced, while the timing of their intervention is few hours vs days required for T cell-mediated adaptive responses. On the other hand, the effectiveness of ILC in anti-tumor defenses is controversial. The relevance of NK cells in the control of tumor growth and metastasis has been well documented and they have been exploited in the therapy of high risk leukemia in the haploidentical hematopoietic stem cell transplantation setting...
November 12, 2018: Immunology Letters
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