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Immunology Letters

Nadia Ben Fredj, Kaouthar Sakly, Daria Bortolotti, Mouna Aissi, Mahbouba Frih-Ayed, Antonella Rotola, Elisabetta Caselli, Franscesca Cura, Nabil Sakly, Mahjoub Aouni, Dario Di Di Luca, Roberta Rizzo
We aimed to investigate two main polymorphisms in the 3' untranslated region (3'UTR) of the HLA-G gene [14 bp insertion/deletion (INS/DEL) and +3142 C>G] and to assess their impact on the soluble HLA-G (sHLA-G) production in patients with multiple sclerosis (MS). This study included 60 patients with relasping-remitting (RR) MS and 112 healthy donors (HD). Mutations were identified by PCR and PCR-RFLP, and serum sHLA-G quantification was performed by ELISA. For the 14 bp INS/DEL polymorphism, variants frequencies were similar in patients and controls, whereas a significant increased frequency of the +3142 G allele was found in MS patients compared to HD (63...
October 19, 2016: Immunology Letters
Marcelo Arantes Levenhagen, Hélio Conte, Julia Maria Costa-Cruz
Strongyloides stercoralis is a helminth parasite that can infect millions of people worldwide, particularly in tropical, subtropical and temperate regions with poor sanitation. Several aspects of epidemiology, biology and host-parasite interactions of S. stercoralis have been studied, and substantial knowledge has been acquired; however, very few studies on immunotherapeutic control strategies to prevent infection and disease in humans have been conducted. Therefore, this article reviews the current progress and targets toward vaccine and passive immunization approaches for Strongyloides spp...
October 18, 2016: Immunology Letters
Min Zhang, Zhongqi Zhou, Jinguang Wang, Shufa Li
Inflammatory pathways play an important role in impaired glucose metabolism and insulin production. Adipose tissue inflammation is characterized by infiltration and expansion of macrophages, leading to type 2 diabetes (T2D). Macrophage polarization contributes to various inflammatory responses and cytokine production profiles. MiR-130b is involved in regulating immune response and metabolism. However, the specific role in macrophage polarization and glucose metabolism of T2D has not been reported. In this study, C57BL/6 mice were fed a high-fat diet to induce T2D mice model...
October 13, 2016: Immunology Letters
Raffaella Mormile
No abstract text is available yet for this article.
October 12, 2016: Immunology Letters
Anne Kresinsky, Nadine Schneble, Caroline Schmidt, Adrian Frister, Reinhard Bauer, Reinhard Wetzker, Jörg P Müller
Due to their ability to phagocytise invading microbes macrophages play a key role in the innate and acquired immune system. In this article the role of phosphoinositide 3-kinase gamma (PI3Kγ) for phagocytosis was studied in bone marrow derived macrophages (BMDM). By using genetic and pharmacological approaches our data clearly demonstrate PI3Kγ is acting as a mediator of macrophage phagocytosis. Phagocytosis of LPS activated BMDM was reduced in PI3Kγ depleted primary BMDM or macrophage cell line J774. Depletion of other class I phosphoinositide 3-kinases did not alter phagocytic activity...
October 5, 2016: Immunology Letters
Lamia Ysmail-Dahlouk, Wafa Nouari, Mourad Aribi
BACKGROUND: Type 1 diabetes (T1D) is associated with an imbalance between inflammation and repair. Recently, the biologically active form of vitamin D3, i.e. 1,25(OH)2D3, has been reported to have potent immunomodulatory effects on both innate and adaptive immune cells, as well as on the production of their specific cytokines. METHODS: We examined the effect of 1,25(OH)2D3 on the production of proinflammatory Th1/Th17 and anti-inflammatory Th2/Treg related cytokines, as well as on the phosphorylation of monocyte-expressed STAT4 and STAT6 at the recent-onset human T1D...
October 4, 2016: Immunology Letters
Bangqing Yuan, Shaokuan Huang, Shuangfeng Gong, Feihong Wang, Li Lin, Tonggang Su, Hanchao Sheng, Hui Shi, Kunlong Ma, Zhao Yang
Neuroinflammation plays an important role in the recovery of brain injury in ICH. Macrophage is the major executor in the neuroinflammation and initiates neurological defects. Programmed death 1 (PD-1) delivers inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. PD-1 expression by macrophages plays a pathologic role in the innate inflammatory response. However, the exact role of PD-1 on inflammatory responses following ICH has not been well identified. In this experiment, PD-1 KO (PD-1 -/-) ICH mice and Wild-type (WT) ICH mice were caused by intracranial injection of type IV collagenase...
October 4, 2016: Immunology Letters
Raffaella Mormile
No abstract text is available yet for this article.
September 27, 2016: Immunology Letters
Yuwei Chenzhang, Qiang Wen, Xianping Ding, Man Cao, Zuyi Chen, Xuemei Mu, Tao Wang
Cervical cancers almost are infected by human papillmavirus (HPV), encoding E6 and E7 oncoproteins which are regard as ideal targets on the mechanism of this disease and development of vaccines. HLA (human leukocyte antigen) participates in the local immune response to prevent tumor invasion and progression. But due to highly polymorphism of HLA, prediction shows its importance in this study. More effective immunoinformatics was used for predicting epitopes from HPV-16 E6 and E7, including T- and B-cell epitopes...
September 27, 2016: Immunology Letters
Ying Hua, Yue-Ying Jiao, Yao Ma, Xiang-Lei Peng, Yuan-Hui Fu, Yan-Peng Zheng, Tao Hong, Jin-Sheng He
Human respiratory syncytial virus (RSV) can cause serious infection in the lower respiratory tract, especially in infants, young children, the elderly and the immunocompromised population worldwide. Previous study demonstrated the polypeptide (amino acids 148-198) of RSV attachment (G) glycoprotein, corresponding to the central conserved region and encompassing CX3C chemokine motif, could induce antibodies and protection from RSV challenge in mice [1,2]. In this study, we evaluated the immune efficacy of the recombinant DNA vaccine of pVAX1/3G148-198 encoding RSV G protein polypeptide...
September 26, 2016: Immunology Letters
Adriane Penczek, Marcin Sienczyk, Christian Rainer Wirtz, Timo Burster
Natural killer (NK) cells are critical in diverse defense mechanisms, including elimination of viral infected cells and destruction of tumor cells. NK cells are characterized by the ability to initiate apoptosis in target cells when their cell surface major histocompatibility complex class I (MHC I) repertoire is missing. On the other hand, NK cells are not activated when MHC I or non-classical MHC molecules are found on the respective cells. It was demonstrated that cathepsin G (CatG) binds to the cell surface of NK cells; however, the distribution of this protease on the cell surface of NK cell subsets has not been identified...
September 24, 2016: Immunology Letters
Chun-Mu Miao, Xiao-Wei Jiang, Kun He, Pei-Zhi Li, Zuo-Jin Liu, Ding Cao, Zhi-Bing Ou, Jian-Ping Gong, Chang-An Liu, Yao Cheng
The nucleotide-binding and oligomerization domain-like receptor 3 (NLRP3) inflammasome participates in the pathogenesis of acute liver injury during sepsis. Bone marrow mesenchymal stem cells (BMSCs) attenuate sepsis through prostaglandin E 2 (PGE2) by increasing the interleukin-10 (IL-10) production of macrophages; moreover, NLRP3 inflammasome assembly is effectively regulated by IL-10 during infection. Whether BMSCs have an effect on the activation of the NLRP3 inflammasome and its underlying mechanism is unclear...
September 22, 2016: Immunology Letters
Ying Wang, Lili Wang, Yanchao Shi, Feifei Wang, Haoyu Yang, Shuo Han, Yanping Bai
Circulating T follicular helper (Tfh) cells in the blood are counterparts to conventional Tfh cells in germinal centres. Similarly to conventional Tfh cells, circulating Tfh cells provide helpful signals for B cells. Circulating Tfh cells can be divided into three subpopulations, including Tfh17 (CXCR3-CCR6+), Tfh1 (CXCR3+CCR6-), and Tfh2 (CXCR3-CCR6-) cells, based on differences in CXCR3 and CCR6 expression. Recent studies have demonstrated that alterations in circulating Tfh cell subsets have significant effects on the progression of numerous autoimmune diseases...
September 20, 2016: Immunology Letters
Hanke L Matlung, Katka Szilagyi, Taco W Kuijpers, Rene A W van Lier, Timo K van den Berg
No abstract text is available yet for this article.
September 20, 2016: Immunology Letters
Maciej Chalubinski, Emilia Luczak, Katarzyna Wojdan, Paulina Gorzelak-Pabis, Marlena Broncel
The low-grade inflammation present in obese visceral adipose tissue impairs glucose metabolism, and contributes to the development of insulin resistance and weight gain. Immune processes occurring in response to the deposition of cholesterol within the vascular walls support atherosclerotic plaque growth and contribute to the cardiovascular complications. In both the obese adipose tissue and the atherosclerotic plaque, the Th1-type immune environment dominates over the Th2/Treg-type due to the overproduction of pro-inflammatory cytokines (IFN-γ, IL-6, TNF-α) and the deficiency of Th2-type processes and interleukins (IL-4, IL-5, IL-10, IL-13)...
September 16, 2016: Immunology Letters
Nicole G Grün, Karin Strohmeier, Veronica Moreno-Viedma, Marie Le Bras, Christine Landlinger, Karina Zeyda, Bettina Wanko, Lukas Leitner, Günther Staffler, Maximilian Zeyda, Thomas M Stulnig
Obesity causes insulin resistance via a chronic low-grade inflammation. This inflammation is characterized by elevated pro-inflammatory markers and macrophage accumulation in the adipose tissue (AT). AT inflammation is a key factor causing insulin resistance and thus type 2 diabetes, both linked to atherosclerotic cardiovascular disease. Osteopontin (OPN), a well-known inflammatory cytokine, is involved in obesity-linked complications including AT inflammation, insulin resistance, atherosclerosis and CVD. During inflammation, OPN is proteolytically cleaved by matrix metalloproteinases or thrombin leading to increased OPN activity...
September 14, 2016: Immunology Letters
Roald Nezlin
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at
September 13, 2016: Immunology Letters
Martina Petrackova, Eva Hamsikova, Martina Duskova, Pavlina Ptackova, Hana Klamova, Zuzana Humlova, Vladimir Vonka
Serum samples taken at diagnosis in 28 chronic myeloid leukemia patients were tested for the presence of 20 cytokines by a magnetic bead-based Bio-plex immunoassay. According to complete cytogenetic remission achieved at 12 months of treatment, patients were divided into groups with either optimal or non-optimal outcome. Patients with increased cytokine levels tended to react optimally to the therapy more frequently than those others. TGF-β3 was a notable exception; its levels were significantly higher in patients with non-optimal outcomes...
September 13, 2016: Immunology Letters
Mingjie Wang, Xindie Zhou, Hui Zhang, Ruiping Liu, Nanwei Xu
To investigate the roles of the plasma vascular endothelial growth factor (VEGF) level and VEGF gene polymorphisms in ankylosing spondylitis (AS) susceptibility. The plasma VEGF level was measured using an enzyme-linked immunosorbent assay. The VEGF rs2010963 G/C gene polymorphism was analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Our data indicated that the average plasma VEGF concentration in the AS patients was markedly higher than in the controls. Stratification analysis indicated a significant correlation between an elevated plasma VEGF level in AS patients and sex, but not age, HLA-B27, C-reactive protein (CRP), or grade of the sacroiliac joint...
September 13, 2016: Immunology Letters
Qiang Wu, Yunxin Wang, Qiuying Wang, Dan Yu, Yuyang Wang, Liying Song, Zhihang Liu, Xianlong Ye, Pengfei Xu, Hongxue Cao, Deshan Li, Guiping Ren
Rheumatoid arthritis (RA) is a chronic, systemic and autoimmune disease with overexpression inflammation cytokines. The biological therapy targeting these inflammatory cytokines has been applied for the clinic. Drugs aimed at a single target are ineffective in some patients with RA. However, double-target and multi-target drugs have huge advantages in therapy. Interleukin-1β (IL-1β) and Interleukin-17A (IL-17A) are the keys to inflammatory factors in RA. The bispecific antibody(BsAb)against both human IL-1β and human IL-17A was formed and expressed in E...
September 8, 2016: Immunology Letters
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