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Immunology Letters

Se-Young Kim, Min-Jung Park, Jeong-Eun Kwon, Kyuong Ah Jung, Joo-Yeon Jhun, Seon-Yeong Lee, Hyeon-Beom Seo, Jae-Yoon Rye, Jin-Ah Beak, Jong-Young Choi, Mi-La Cho
Cucurbitacin E (CuE) is a biochemical compound found in plants that are members of the family CuE has been studied for its roles in anti-inflammation and the inhibition of angiogenesis as well as for its properties as an antioxidant. CuE is a new agent that was identified as a selective inhibitor of the signal transducer and activator of transcription 3 (STAT3)-related pathway. STAT3, a pivotal transcription factor for Th17 differentiation, is critical for T cell alloactivation in acute graft-versus-host disease (aGvHD)...
September 18, 2018: Immunology Letters
A León-Flores, P M Del Río Estrada, L X Álvarez-García, E Piten-Isidro, G Reyes-Terán
Recent evidence has revealed that PD-L1 is expressed in two functional forms, namely, a membrane-bound form (mPD-L1) and a soluble form (sPD-L1). The identification of the soluble form of PD-L1 represents the discovery of a new potential mechanism for the activation of the PD-1 pathway that may mediate a physiological apoptotic mechanism through a cell-cell signalling-independent pathway and may also favour T cell dysfunction during HIV infection. Since the presence of sPD-L1 has not been well established in the scenario of chronic viral infection, we investigated the presence of sPD-L1 in the plasma of viraemic HIV+ individuals and the potential mechanism that promotes its production...
September 17, 2018: Immunology Letters
Ming-Horng Tsai, Chuen-Mao Yang, Kuo-Ting Chang, Chu-Chun Chuang, Wei-Ning Lin, Rong-San Jiang, Cheng-Hsun Wu, I-Ta Lee
Staphylococcus aureus (S. aureus) can often lead to many life-threatening diseases. It has the ability to invade normal endovascular tissue. Acute inflammation and its resolution are important to ensure bacterial clearance and limit tissue injury. Carbon monoxide (CO) has been shown to exert anti-inflammatory effects in various tissues and organ systems. In our study, we investigated the effects and the mechanisms of carbon monoxide releasing molecule-2 (CORM-2) on S. aureus-induced inflammatory responses in human aortic endothelial cells (HAECs)...
September 17, 2018: Immunology Letters
Helen Prasad
No abstract text is available yet for this article.
September 15, 2018: Immunology Letters
Erdem Tüzün, Duygu Gezen-Ak, John Tzartos, Erdinç Dursun, Murat Giriş, Paraskevi Zisimopoulou, Katerina Karagiorgou, Berrak Yetimler, Cem İsmail Küçükali, Halil Atilla İdrisoğlu
No abstract text is available yet for this article.
September 15, 2018: Immunology Letters
Marcus Vinicius M Goncalves, Rodrigo Harger, Vera Braatz, Laura F Parolin, Audred C Biondo Eboni, Maria Aparecida N Fontana, Andrea Anacleto, Yara Dadalti Fragoso
No abstract text is available yet for this article.
September 14, 2018: Immunology Letters
Debora Scaldaferri, Annalisa Bosi, Marco Fabbri, Edoardo Pedrini, Antonio Inforzato, Roberto Valli, Annalisa Frattini, Annarosaria De Vito, Douglas M Noonan, Roberto Taramelli, Lorenzo Mortara, Francesco Acquati
Macrophages represent key inflammatory cellular effectors of the innate immune response. Despite being widely acknowledged as professional phagocytes, the functional roles played by these cells have been progressively widened over the years to encompass regulation of the adaptive immune system, stimulation or suppression of cancer cell growth and tissue remodeling. These diverse functional features have led to the concept of "macrophage plasticity", i.e. the ability of these cells to express a wide range of phenotypes endowed with different functional roles...
September 12, 2018: Immunology Letters
Tue G Nguyen
Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2 (Th1/2) responses in vivo. It is not known whether these effects by anti-IgD exacerbates or ameliorates chronic skin inflammations. This study investigated the effects of anti-IgD and B-cell depleting anti-CD20 antibody on skin inflammation in CHS murine models...
September 12, 2018: Immunology Letters
Xuejuan Bai, Dongfang Wang, Yinping Liu, Li Xiao, Yan Liang, Yourong Yang, Junxian Zhang, Minggui Lin, Xueqiong Wu
There is an urgent need for a more effective vaccine against tuberculosis (TB). Cytotoxic T lymphocytes (CTLs) play a critical role in combating Mycobacterium tuberculosis (M.tb). The identification of novel CTL epitopes is essential for the design of peptide-based vaccines. In this study, we predicted CTL epitope peptides of M.tb antigen Rv2629 restricted by HLA-A2, using bioinformatics methods. The affinity and stability of binding of these peptides with HLA-A2 molecules were detected by flow cytometry. Their ability to induce CTLs generation was determined in peripheral blood mononuclear cells (PBMCs) from healthy uninfected subjects, Latent tuberculosis infection (LTBI) subjects, and TB patients ex vivo...
September 12, 2018: Immunology Letters
Bitnara Lee, Sungsin Jo, Sung-Min Kim, Mi-La Cho, Sung-Hwan Park, Jeehee Youn, Jong Dae Ji, Tae-Hwan Kim
Poly-γ-glutamic acid (γ-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of γ-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that γ-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. γ-PGA also reduces RANK expression by down-regulating M-CSF receptors...
September 10, 2018: Immunology Letters
Bai-Sui Feng, Yong-Jin Wu, Jing-Yi Hong, Xiao-Rui Geng, Jiang-Qi Liu, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
The skewed T helper (Th) 2 response plays a central role in the pathogenesis of allergic diseases, while its initiating factors remain elusive. Recent studies indicate that Bcl2 like protein-12 (Bcl2L12) is associated with the Th2-biased inflammation. This study is designed to test a hypothesis that Bcl2L12 plays a critical role in the initiation of allergic response. In this study, peripheral CD4+ T cells were isolated from food allergy (FA) patients and healthy subjects; A mouse FA model was developed to test the role of Bcl2L12 in induction of allergic response in the intestine...
September 5, 2018: Immunology Letters
Buenaventura Brito Díaz, Delia Almeida González, Fadoua Gannar, M Cristo Rodríguez Pérez, Antonio Cabrera de León
Myokines are peptides produced and released by myocytes of muscle fibers that influence physiology of muscle and other organs and tissues. They are involved in mediating the beneficial effects that exercise has on health. More than one hundred have been identified and among them are IL6, myostatin, irisin, mionectin and decorin. Physical inactivity leads to an altered response of the secretion of myokines and resistance to them; this leads to a pro-inflammatory state that favors sarcopenia and fat accumulation, promoting the development of cardiovascular diseases, insulin resistance, and diabetes mellitus type 2...
September 5, 2018: Immunology Letters
Zara Hannoun, Zhansong Lin, Simon Brackenridge, Nozomi Kuse, Tomohiro Akahoshi, Nicola Borthwick, Andrew McMichael, Hayato Murakoshi, Masafumi Takiguchi, Tomáš Hanke
Non-classical class Ib MHC-E molecule is becoming an increasingly interesting component of the immune response. It is involved in both the adaptive and innate immune responses to several chronic infections including HIV-1 and, under very specific circumstances, likely mediated a unique vaccine protection of rhesus macaques against pathogenic SIV challenge. Despite being recently in the spotlight for HIV-1 vaccine development, to date there is only one reported human leukocyte antigen (HLA)-E-binding peptide derived from HIV-1...
August 30, 2018: Immunology Letters
Laura Ambra Nicolini, Silvia Dettori, Federica Bozzano, Antonio Di Biagio, Andrea De Maria
No abstract text is available yet for this article.
August 22, 2018: Immunology Letters
Mehdi Shahbazi, Mehdi Soltanzadeh-Yamchi, Mousa Mohammadnia-Afrouzi
Exhaustion of lymphocyte function, particularly T cell exhaustion, due to prolonged exposure to a high load of foreign antigen is commonly seen during chronic viral infection as well as antitumor immune responses. This phenomenon has been associated with a determined molecular mechanism and phenotypic manifestations on the cell surface. In spite of investigation of exhaustion, mostly about CD8 responses toward viral infections, recent studies have reported that chronic exposure to antigen may develop exhaustion in CD4 + T cells, B cells, and NK cells...
August 18, 2018: Immunology Letters
Emil Bulatov, Aygul Valiullina, Regina Sayarova, Albert Rizvanov
Ubiquitin-proteasome system (UPS) is a primary signaling pathway for regulation of protein turnover and removal of misfolded proteins in eukaryotic cells. Enzymes of the UPS pathway - E1 activating, E2 conjugating, E3 ligating - act together to covalently tag substrate proteins with a chain of ubiquitins, small regulatory proteins. The poly-ubiquitin chain then serves as a recognition motif for 26S proteasome to recognize and degrade the substrate. In recent years UPS has emerged as attractive enzymatic cascade for development of novel therapeutics against various human diseases...
August 9, 2018: Immunology Letters
Eva Reijmen, Luca Vannucci, Marijke De Couck, Jacques De Grève, Yori Gidron
Accumulating evidence points to a beneficial effect ofvagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the α7nAChR. Since α7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment...
August 2, 2018: Immunology Letters
Wei Li, Zhuo Liu, Renqiao Tang, Shengrong Ouyang, Sen Li, Jianxin Wu
Vitamin D insufficiency is associated with chronic inflammatory diseases. However, the mechanism by which vitamin D reduces obesity-related inflammation remains poorly understood. In this study, we investigated the inhibitory effects of vitamin D on palmitate-induced inflammatory response in macrophages and explored the potential mechanisms of vitamin D action. The effect of vitamin D on the expression of inflammatory factors induced by palmitate, a saturated fatty acid, was investigated using human THP-1 macrophages and murine RAW 264...
August 1, 2018: Immunology Letters
Markus Bauswein, Anurag Singh, Anjali Ralhan, Davide Neri, Katharina Fuchs, Kelly Daryll Blanz, Iris Schäfer, Andreas Hector, Rupert Handgretinger, Dominik Hartl, Nikolaus Rieber
Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of suppressing T-cell responses in cancer and chronic inflammation. While the effect of MDSC on T cells has been defined thoroughly, the reciprocal impact of T cells on MDSC homeostasis remains poorly understood. Therefore, we comprehensively analyzed the effect of different T-cell subsets on the generation and survival of human MDSC. Using an in vitro MDSC generation assay, we demonstrate that unstimulated CD4+ , but not CD8+ T cells, induce polymorphonuclear MDSC (PMN-MDSC) from CD33+ myeloid cells...
August 1, 2018: Immunology Letters
Yan Chen, Daoxin Wang, Yan Zhao, Bin Huang, Haiquan Cao, Di Qi
Acute respiratory distress syndrome (ARDS) has been the major cause of acute respiratory failure in critical patients and one of the leading causes of death worldwide for several decades. Th17 cells are involved in the occurrence and progression of ARDS. Furthermore, histone acetyltransferase (HAT) p300 is a transcriptional coactivator, and its activity is closely related to cancer and inflammatory diseases. p300 and histone deacetylase 1 (HDAC1) interact with and stabilize the nuclear transcription factor retinoic acid-related orphan receptor gamma t (RORγt) and participate in the regulation of RORγt-mediated IL-17 transcription in T helper 17 (Th17) cell differentiation by acetylation and deacetylation...
July 28, 2018: Immunology Letters
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