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Therapeutic Drug Monitoring

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https://www.readbyqxmd.com/read/29746395/a-liquid-chromatography-mass-spectrometry-assay-for-determination-of-perampanel-and-concomitant-antiepileptic-drugs-in-the-plasma-of-patients-with-epilepsy-compared-with-a-fluorescent-hplc-assay
#1
Ugo de Grazia, Annachiara D'Urso, Federica Ranzato, Valentina De Riva, Giorgia Contarato, Giuseppe Billo, Francesco Perini, Elisabetta Galloni
BACKGROUND: Perampanel is a novel non-competitive selective antagonist at the postsynaptic ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) glutamate receptor, approved as an adjunctive agent for the treatment of partial-onset seizure with or without secondary generalization and for primary generalized tonic-clonic seizure in patients with epilepsy who are at least 12 years of age. Limited information is available about the clinical utility of therapeutic drug monitoring of perampanel and therapeutic ranges are so far not established...
May 9, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29746394/pharmacokinetics-of-doripenem-in-healthy-koreans-and-monte-carlo-simulations-to-explore-optimal-dosage-regimens-in-patients-with-normal-and-enhanced-renal-function
#2
So Won Kim, Sangmin Choe, Dong Jin Kim, Dae Young Zang, Dong-Hwan Lee
BACKGROUND: Dose adjustment is often required in patients with normal or enhanced renal function. The aim of this study is to investigate the pharmacokinetic (PK) properties of doripenem and explore optimal dosing regimens in patients with normal or enhanced renal function according to various minimum inhibitory concentrations (MIC). METHODS: The authors conducted a clinical trial and analyzed PK samples in 11 healthy Korean subjects applying non-compartmental analysis (NCA) and a population approach...
May 9, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29746397/impact-of-drug-interactions-on-clobazam-and-n-desmethylclobazam-concentrations-in-pediatric-patients-with-epilepsy
#3
Gabrielle R Russell, Stephanie J Phelps, Chasity M Shelton, James W Wheless
BACKGROUND: Clobazam (CLB) is approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients ≥2 years of age. It is converted to an active metabolite N-desmethylclobazam (NCLB) by CYP3A4, which is then broken down to an inactive metabolite by CYP2C19. This study characterizes the impact of CYP3A4 and CYP2C19 drug interactions on CLB and NCLB serum concentrations (Cp) and concentration/dose (Cp/D) ratios in pediatric patients with epilepsy. METHODS: This was a retrospective chart review including patients >1 month of age, who received CLB between April 2012 and March 2017...
May 4, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29746396/development-of-an-abbreviatted-mycophenolic-acid-area-under-the-time-concentration-curve-for-renal-transplanted-patients-under-enteric-coated-mycophenolate-sodium-a-comparison-with-critical-analysis-of-available-equations
#4
Elias David-Neto, Ana Heloisa Triboni, Fernanda Ramos, Fabiana Agena, Paschoalina Romano
BACKGROUND: Enteric-coated mycophenolate sodium (EC-MPS) is frequently used in renal transplantation. The pharmacokinetic profile of mycophenolic acid (MPA) shows a broad range of time-to-maximum-concentration (Tmax) that limits the use of a single MPA concentration to calculate the area under the time-concentration curve (AUC). For both research and clinical MPA monitoring, measuring a complete AUC is troublesome to the center and patients. METHODS: We obtained 171 complete MPA-AUC12h (0, 20,40,60,90,120, 180, 240, 360, 480, 600, 720 min) from 59 adult (54±16 years) patients (29 male, 43 whites) who have been receiving stable doses of Tacrolimus/EC-MPS and steroids...
May 4, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29750737/inter-and-intraindividual-variation-of-methylphenidate-concentrations-in-serum-and-saliva-of-patients-with-attention-deficit-hyperactivity-disorder
#5
Joshua Preiskorn, Sophie Studer, Reinhold Rauh, Richard Lukačin, Christoph Geffert, Christian Fleischhaker, Hans-Willi Clement, Eberhard Schulz, Monica Biscaldi
BackgroundTherapeutic drug monitoring (TDM) is becoming increasingly important in psychiatric therapy; especially in children. However, for several reasons, it cannot yet be implemented as a daily routine in clinical or outpatient settings. To evaluate new, non-invasive procedures; blood and saliva (oral fluid) samples were collected from patients with attention-deficit/hyperactivity disorder (ADHD) who were also being administered methylphenidate (MPH). The study's main purposes were to correlate MPH concentrations in serum and saliva between subjects; and to analyze intraindividual variation of serum concentration...
May 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29750740/development-and-validation-of-a-chromatographic-uv-method-for-the-quantification-of-isavuconazole-in-human-plasma-samples
#6
Valeria Cozzi, Sara Baldelli, Simone Castoldi, Emilio Clementi, Dario Cattaneo
No abstract text is available yet for this article.
April 30, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29750739/mass-spectrometry-for-research-and-application-in-therapeutic-drug-monitoring-or-clinical-and-forensic-toxicology
#7
Hans H Maurer
This paper reviews current applications of various hyphenated low- and high-resolution mass spectrometry techniques in the field of therapeutic drug monitoring and clinical/forensic toxicology in both research and practice. They cover gas chromatography, liquid chromatography, matrix-assisted laser desorption ionization, or paper spray ionization coupled to quadrupole, ion trap, time-of-flight, or Orbitrap mass analyzers.
April 30, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29750738/large-scale-variability-of-inpatient-tacrolimus-therapeutic-drug-monitoring-at-an-academic-transplant-center-a-retrospective-study
#8
Garth W Strohbehn, Warren W Pan, Christopher M Petrilli, Lauren Heidemann, Sophia Larson, Keith D Aaronson, Matt Johnson, Tammy Ellies, Michael Heung
BACKGROUND: Inpatient tacrolimus therapeutic drug monitoring (TDM) lacks standardized guidelines. In this study, the authors analyzed variability in the pre-analytical phase of the inpatient tacrolimus TDM process at their institution. METHODS: Patients receiving tacrolimus (twice-daily formulation) and tacrolimus laboratory analysis were included in the study. Times of tacrolimus administration and laboratory study collection were extracted and time distribution plots for each step in the inpatient TDM process were generated...
April 30, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29683874/time-dependent-decline-in-serum-phenytoin-concentration-with-heightened-convulsive-seizure-risk-by-prolonged-administration-of-fosphenytoin-in-japanese-a-retrospective-study
#9
Yuta Ohno, Takashi Niwa, Keita Hirai, Keiko Suzuki, Yuto Yamada, Yuichi Hayashi, Hideki Hayashi, Akio Suzuki, Yoshinori Itoh
BACKGROUND: Because clinical data to confirm the safety and effectiveness of fosphenytoin, a prodrug of phenytoin, are insufficient, the length of administration of fosphenytoin is restricted. Nevertheless, some cases require fosphenytoin administration for more than a few days. The aim of this study was to retrospectively investigate the serum concentration of phenytoin in adult Japanese patients who received intravenous fosphenytoin therapy for more than 3 days. METHODS: Patients injected with intravenous fosphenytoin for more than 3 days at Gifu University Hospital between January 2012 and September 2014 were enrolled...
April 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29683873/eltrombopag-induced-acute-liver-failure-in-a-pediatric-patient-a-pharmacokinetic-and-pharmacogenetic-analysis
#10
M Marano, J Serafinelli, S Cairoli, D Martinelli, M Pisani, G Palumbo, M G Cefalo, C Cecchetti, M Di Nardo, F S Falvella, B M Goffredo
Eltrombopag is an oral thrombopoietin-receptor-agonist (TPO-RA) approved for the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP), who are more than one year old, and show poor response to first-line therapy. ITP is a hematological disorder characterized by isolated thrombocytopenia in the absence of secondary causes or disorders. Eltrombopag is generally well tolerated in the pediatric population, therefore therapeutic drug monitoring (TDM) is not usually performed in clinical practice...
April 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29649094/methadone-maintenance-treatment-a-15-year-retrospective-study-in-split-dalmatia-county-croatia
#11
Davorka Sutlovic, Zeljko Kljucevic, Livia Sliskovic, Helena Susnjar, Ivo Viskovic, Marija Definis-Gojanovic
BACKGROUND: The aim of this retrospective study is to use existing epidemiological data on patients in methadone maintenance treatment in Split Dalmatia County from 2001 to 2015 in order to evaluate the substitution treatment system and policy of opiate addicts treatment, the epidemiological trend, and risk of overdose mortality. In addition, we would like to highlight the problem of poor control of methadone therapy, and thus the possibility of selling methadone. The result is a greater number of deaths caused by methadone in people who were not in methadone therapy...
April 11, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29649093/comparison-of-cyp3a4-inducing-capacity-of-enzyme-inducing-antiepileptic-drugs-using-4%C3%AE-hydroxycholesterol-as-biomarker
#12
Kristine Hole, Birgit M Wollmann, Camilla Nguyen, Tore Haslemo, Espen Molden
BACKGROUND: Enzyme-inducing antiepileptic drugs (EIAEDs) are among the clinically most important inducers of cytochrome P450 (CYP) 3A4, but there is limited evidence regarding the comparative potency of each EIAED in raising CYP3A4 activity. The aim of this study was to estimate CYP3A4-inductive potency of EIAEDs by comparing CYP3A4 activity in patients treated with carbamazepine, phenobarbital, or phenytoin. METHODS: Residual serum samples from patients treated with EIAEDs or levetiracetam were collected from a therapeutic drug monitoring service for analysis of 4β-hydroxycholesterol (4βOHC), which is an indicator of CYP3A4 activity...
April 11, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29621124/therapeutic-drug-monitoring-of-methotrexate-in-plasma-using-u-hplc-ms-ms-necessary-after-administration-of-glucarpidase-in-methotrexate-intoxications
#13
Midas B Mulder, Ruud Huisman, Frederike K Engels, Inge M van der Sluis, Birgit C P Koch
High-dose methotrexate (HD-MTX) is used to treat a variety of cancers. In all patients receiving HD-MTX, plasma MTX levels are monitored mainly to anticipate rescue therapy to prevent adverse events. We present two children treated with HD-MTX and afterward treated with glucarpidase at different time-points after their HD-MTX infusions. After the administration of glucarpidase, a non-toxic metabolite of MTX cross-reacts with MTX in the standard immunoassay (Abbott Diagnostics, Hoofddorp, The Netherlands) resulting in an artificially elevated MTX level...
April 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29621123/development-and-validation-of-a-u-hplc-ms-ms-method-for-the-concurrent-measurement-of-gabapentin-lamotrigine-levetiracetam-monohydroxy-derivative-mhd-of-oxcarbazepine-and-zonisamide-concentrations-in-serum-in-a-clinical-setting
#14
Michael J Palte, Sankha S Basu, Jameson L Dahlin, Ralitsa Gencheva, Donald Mason, Petr Jarolim, Athena K Petrides
BACKGROUND: Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is often necessary to prevent associated destructive toxicities. Tandem mass spectrometry (MS/MS) with stable-isotope-labeled (SIL) internal standards (ISs) is considered the gold standard for the measurement of AEDs. This study presents the development and validation of a clinical ultra-performance liquid chromatography (U-HPLC)-MS/MS method for the concurrent measurement of gabapentin, lamotrigine, levetiracetam, monohydroxy derivative (MHD) of oxcarbazepine, and zonisamide in human serum...
April 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29621122/survival-time-to-biopsy-proven-acute-rejection-and-tacrolimus-adverse-drug-reactions-in-pediatric-liver-transplantation
#15
Natalia Riva, Marcelo Dip, Esteban Halac, Paulo Cáceres Guido, Jean Baptiste Woillard, Nieves Licciardone, Debora Chan, Jefferson Buendía, Daniela Borgnia, Andrea Bosaleh, María Teresa de Davila, Oscar Imventarza, Paula Schaiquevich
BACKGROUND: Despite advances in surgical procedures and the optimization of immunosuppressive therapies in pediatric liver transplantation, acute rejection (AR) and serious adverse drug reaction (ADR) to tacrolimus still contribute to morbidity and mortality. Identifying risk factors of safety and efficacy parameters may help in optimizing individual immunosuppressive therapies. This study aimed to identify peritransplant predictors of AR and factors related to the risk of ADR to tacrolimus in a large Latin-American cohort of pediatric liver transplant patients...
April 3, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29608486/simultaneous-quantification-of-adalimumab-and-infliximab-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry
#16
Jean-François Jourdil, Benjamin Némoz, Elodie Gautier-Veyret, Charlotte Romero, Françoise Stanke-Labesque
BACKGROUND: Adalimumab (ADA) and infliximab (IFX) are therapeutic monoclonal antibodies (TMabs) targeting tumor necrosis factor-alpha (TNFα). They are used to treat inflammatory diseases. Clinical trials have suggested that therapeutic drug monitoring for ADA or IFX could improve treatment response and cost-effectiveness. However, ADA and IFX were quantified by ELISA in all these studies, and the discrepancies between the results obtained raise questions about their reliability.We describe here the validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of ADA and IFX in human samples...
March 30, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29601407/effect-of-valproate-and-antidepressant-drugs-on-clozapine-metabolism-in-patients-with-psychotic-mood-disorders
#17
Donatella Marazziti, Lionella Palego, Laura Betti, Gino Giannaccini, Enrico Massimetti, Stefano Baroni, Antonio Ciapparelli, Antonio Lucacchini, Federico Mucci, Liliana Dell'Osso
BACKGROUND: The aim of the present study was to appraise retrospectively the influence of valproate (VPA) and antidepressants (ADs) on the steady-state plasma concentrations of clozapine (CLZ), the prototype of various second-generation antipsychotics (SGAs), norclozapine (NCLZ, its main metabolite), and their ratio (NCLZ/CLZ). METHODS: Sixty-seven psychotic patients with a prevalent diagnosis of bipolar disorder (BD) were studied. We then analyzed data altogether and subdivided them into four groups, according to pharmacological treatments: #1 CLZ (n=21), #2 CLZ plus antidepressants (ADs) (n=13), #3 CLZ plus VPA (n=16), and #4 CLZ plus ADs plus VPA (n=17)...
March 29, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29578938/quantification-of-apixaban-dabigatran-edoxaban-and-rivaroxaban-in-human-serum-by-uhplc-ms-ms-method-development-validation-and-application
#18
Sofia Lindahl, Roar Dyrkorn, Olav Spigset, Solfrid Hegstad
BACKGROUND: Direct oral anticoagulants (DOACs) are prescribed for anticoagulation in patients with atrial fibrillation and venous thromboembolic disease. Fixed doses are recommended, but measuring their serum drug concentrations as a basis for dose adjustments may be useful in some clinical settings. METHODS: A UHPLC-MS/MS method for the analysis of the DOACs apixaban, dabigatran, edoxaban, and rivaroxaban in human serum was developed and validated. A 100-µL serum sample was handled using a pipetting robot...
March 23, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29578937/determination-of-tacrolimus-concentration-and-protein-expression-of-p-glycoprotein-in-single-human-renal-core-biopsies
#19
Veronica Krogstad, Nils Tore Vethe, Ida Robertsen, Grete Hasvold, Anne-Marthe Due Ose, Monica Hermann, Anders Mikal Andersen, Joe Chan, Morten Skauby, My Hanna Sofia Svensson, Anders Åsberg, Hege Christensen
BACKGROUND: Tacrolimus is currently the cornerstone of immunosuppressive protocols for renal transplant recipients. Despite therapeutic whole blood monitoring, tacrolimus is associated with nephrotoxicity and it has been hypothesized that intrarenal accumulation of tacrolimus and/or its metabolites are involved. As tacrolimus is a substrate of P-glycoprotein (P-gp), the expression and activity of this efflux transporter could influence the levels of tacrolimus in renal tissue. The primary aim of this study was to develop and validate a method for quantification of tacrolimus in tissue homogenates from single human renal core biopsies...
March 23, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29570504/effects-of-cytochrome-p450-cyp-2c19-genotypes-on-steady-state-plasma-concentrations-of-escitalopram-and-its-desmethyl-metabolite-in-japanese-patients-with-depression
#20
Shoko Tsuchimine, Shinichiro Ochi, Misuzu Tajiri, Yutaro Suzuki, Norio Sugawara, Yoshimasa Inoue, Norio Yasui-Furukori
BACKGROUND: Plasma concentrations of the S-enantiomer of citalopram were different between extensive and poor CYP2C19 metabolizers in healthy subjects and depressed patients. However, most studies applied dose-corrected concentrations. Thus, we studied the effects of polymorphisms of the CYP2C19 gene on raw plasma drug concentrations in Japanese patients with depression. METHODS: Subjects in this study consisted of 412 depressed patients receiving 5, 10, 15, or 20 mg of escitalopram once a day...
March 22, 2018: Therapeutic Drug Monitoring
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