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International Journal of Biological Macromolecules

Mohammad Asif Shah, Saroj Mishra, Tapan Kumar Chaudhuri
Protein folding is an extremely complex and fast, yet perfectly defined process, involving interplay of many intra and inter-molecular forces. In vitro, these molecular interactions are reversible for many proteins e.g., smaller and monomeric, organized into single domains. However, refolding of larger multi-domain/multimeric proteins is much more complicated, proceeds in a hierarchal way and is often irreversible. In a comparative study on two large, multi-domain and multimeric isozymes, β -glucosidase I (BGLI) and β-glucosidase II (BGLII) from Pichia etchellsii, we studied spontaneous and assisted refolding under three denaturing conditions viz...
November 12, 2017: International Journal of Biological Macromolecules
Hong Sun, Yifeng Zhang, Yuhua Shi, Yangwei Li, Wei Li, Zhenlong Wang
Lasiopodomys mandarinus, a subterranean rodent, spends its entire life underground. To test whether the CLOCK and BMAL1 genes of L. mandarinus have undergone adaptive evolution to underground darkness, we cloned and analyzed their complete cDNA sequences, using Lasiopodomys brandtii as a control. The phylogenetic trees of the CLOCK and BMAL1 genes were similar to the trees of the conserved Cyt b gene,further, L. mandarinus clustered with L. brandtii and Microtus ochrogaster in the phylogenetic tree. The Q-rich region of the CLOCK gene in L...
November 12, 2017: International Journal of Biological Macromolecules
A I Castillo Andrade, C Rivera Bautista, C Godínez Hernández, Ruiz Cabrera, C Fuentes Ahumada, E García Chávez, A Grajales Lagunes
A prospective completely randomized experimental study was conducted using 48 animals to evaluate the physiometabolic effects of Agave salmiana fructans as a dietary supplement in healthy Wistar rats. Five fructans concentrations from 5 to 20% (w/w) and one control were used in the rats' diet and were divided into six groups (n=8 rats/group). The treatments were carried out for 35 days, during which glucose, cholesterol, triglycerides, body-weight gain, food intake, fecal excretion, organ weights, renal and hepatic functions and a histological analysis of the cecum were evaluated...
November 11, 2017: International Journal of Biological Macromolecules
Nikola Gligorijević, Martina Zámorová Križáková, Ana Penezić, Jaroslav Katrlík, Olgica Nedić
Different factors affect coagulation process. Since fibrinogen is the main coagulation factor, the influence of aging on fibrinogen structure and function was investigated in this study. Fibrinogen was isolated from plasma obtained from healthy persons in the age range 21-83 and examined. Lectin microarray analysis demonstrated increased glycosylation of fibrinogen due to aging, with predominant increase in high-mannose or hybrid type N-glycans, as well as tri-/tetraantennary complex N-glycans with greater content of galactose and N-acetylglucosamine residues...
November 11, 2017: International Journal of Biological Macromolecules
Ali Heydari, Seyed Mohammad Ali Razavi, Mahdi Irani
In this paper, influence of temperature (25, 35, 45 and 55°C) and sugars (sucrose and lactose) at different concentrations (0, 5, 10 and 15%) on some molecular parameters of starches from two canary seed varieties (C05041 and CDC Maria) in the dilute regime were investigated in comparison to wheat starch (WS). The results indicated that the intrinsic viscosity ([η]) values of C05041, CDC Maria and WS samples were 1.42, 1.46 and 1.70 dl/g at 25°C, respectively. Intrinsic viscosity of selected starches decreased with an increase in temperature, but the effect of high temperatures were somewhat unnoticeable...
November 11, 2017: International Journal of Biological Macromolecules
Mohammad G Dekamin, Zahra Karimi, Zahra Latifidoost, Siamand Ilkhanizadeh, Hamed Daemi, M Reza Naimi-Jamal, Mehdi Barikani
Alginic acid, a widely used naturally occurring carbohydrate which is generally derived from brown seaweeds, can be considered as a bifunctional heterogeneous and green biopolymeric organocatalyst. Alginic acid, without any post-modification with active Bronsted or Lewis acid centers, was found to be a highly active, cost-effective, commercially-available, renewable and recoverable heterogeneous biopolymeric organocatalyst for the expeditious synthesis of polyhydroquinolines (PHQs). Polyhydroquinolines were synthesized from the four-component Hantzsch reaction of ethyl acetoacetate, different aldehydes, ammonium acetate and cyclic 1,3-diones under mild conditions in high to quantitative yields, 75-97%, using alginic acid...
November 11, 2017: International Journal of Biological Macromolecules
Li-Shang Dai, Xu-Dong Zhou, Saima Kausar, Muhammad Nadeem Abbas, Liang Wu, Hai-Ling Zhou
The cucumber moth, Diaphania indica (Saunders) (Lepipdoptera: Pyralidae) is an economically important insect pest of cucurbits and is widely distributed in tropical and sub-tropical regions. Herein, we obtained entire mitochondrial genome (mitogenome) sequence of D. indica using polymerase chain reaction amplification and sequencing method. The complete mitogenome of D. indica is 15,367bp long, including 13 protein coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs) and an A+T rich element...
November 11, 2017: International Journal of Biological Macromolecules
Chengmei Shi, Furong Tao, Yuezhi Cui
A new starch-based ester Starch-EDTAD-NHS (SEN) was successful prepared firstly and used to modify gelatin films by amidation. (1)H NMR, FTIR spectra, XRD curves, elemental analysis and Van Slyke method verified the synthesis and confirmed the crosslinking procedure. The properties of the composite SEN-Gel film, such as mechanical test, surface hydrophobicity, light barrier performance, water uptake studies, morphology and solubility behavior were studied. The results of water contact angle showed the hydrophobicity of the films, and the obtained transparency values indicated that the films were opaque...
November 11, 2017: International Journal of Biological Macromolecules
Gulam Rabbani
Nature has selected osmolytes to protect intracellular macromolecules against denaturing stress conditions. These molecules are accumulated in the intracellular environment at considerably high concentrations. In general, osmolytes are known to stabilize proteins. Osmolytes are small naturally occurring compound that are utilized as chemical chaperones by changing the environmental condition in diseased cellular stress state. Osmolytes are present in different organisms, including microorganisms, animals and plants...
November 11, 2017: International Journal of Biological Macromolecules
Jian Wu, Alei Geng, Rongrong Xie, Hongcheng Wang, Jianzhong Sun
A β-glucosidase gene from Bacillus cellulosilyticus was expressed in Escherichia coli BL21 and characterized. The recombinant enzyme (BcBgl1A) showed the optimal activity at 40°C, and the half-life of BcBgl1A activity at 40 °C was 24 h. BcBgl1A was sensitive to heat and exhibited obvious cold-adapted activity, retained 27.2% and 46.5% of the optimal activity at 4 and 20°C, respectively. The best activity was observed at pH 7.0 and stable over the range of pH 6.0-8.0. The activity was significantly enhanced by Fe(2+), Fe(3+) and Mn(2+), also showed a high level of NaCl tolerance...
November 11, 2017: International Journal of Biological Macromolecules
Shahid-Ul-Islam, Shahnawaz Ahmad Wani, Faqeer Mohammad
In recent years, considerable attention has been given to plant colorants for use in dyeing applications because of their newly discovered properties such as insect repellency, deodorizing, antioxidant, sun protection, and antibacterial activity. In view of their better biocompatibility, biodegradability, less-toxicity, natural colorants are gaining worldwide interest for producing elegant hues and highly functional value-added textiles. In the present work, we investigated the coloring and functional finishing of wool with Tectona grandis L leaves extract with the emphasis on effect of metallic salt mordants on colorimetric potential, fastness, radical scavenging potential, and antibacterial activity in an attempt to develop bioactive fibres for use in health care applications...
November 10, 2017: International Journal of Biological Macromolecules
Abdulmannan Fadel, Ayman M Mahmoud, Jason J Ashworth, Weili Li, Yu Lam Ng, Andrew Plunkett
Arabinoxylans (AXs) are major dietary fibers. They are composed of backbone chains of β-(1-4)-linked xylose residues to which α-l-arabinose are linked in the second and/or third carbon positions. Recently, AXs have attracted a great deal of attention because of their biological activities such as their immunomodulatory potential. Extraction of AXs has some difficulties; therefore, various methods have been used to increase the extractability of AXs with varying degrees of success, such as alkaline, enzymatic, mechanical extraction...
November 10, 2017: International Journal of Biological Macromolecules
Sung Won Ko, Juan Paolo E Soriano, Afeesh Rajan Unnithan, Ji Yeon Lee, Chan Hee Park, Cheol Sang Kim
Cellulose I and II polymorphs were isolated from Capsosiphon fulvescens (CF) using the conventional method of extraction and direct mercerization of raw sample, respectively. The morphological and structural differences between the isolated polymorphs were studied by FTIR, FESEM and XRD. Direct mercerization of raw CF yielded the transformation of highly crystalline cellulose I (81.3%) to II (63.7%) as observed in the shifting of XRD patterns. The derived cellulose I and II were hydrolyzed (60% w/w H2SO4, 55°C, 1hr, 10mL/g) to obtain the spindle-shaped cellulose nanocrystals...
November 10, 2017: International Journal of Biological Macromolecules
Éder Galinari, Jailma Almeida-Lima, Gorete Ribeiro Macedo, Hilário Cuquetto Mantovani, Hugo Alexandre Oliveira Rocha
This study evaluated the antioxidant, antiproliferative, and immunostimulatory properties of cell wall α-D-mannan fractions from yeast Kluyveromyces marxianus CCT7735. Filter centrifugation was used to obtain four fractions (KMM-1, KMM-2, KMM-3, and KMM-4) with molecular weight ranging from 7.6 to 75.1kDa. KMM-1 and KMM-2 comprised D-mannose with traces of D-glucose, whereas other fractions contained only D-mannose. Total sugar found in samples ranged from 85.9% to 96.1%, while protein and phenolic contents were 1...
November 10, 2017: International Journal of Biological Macromolecules
Wei Xu, Qian Liu, Yuxiang Bai, Shuhuai Yu, Tao Zhang, Bo Jiang, Wanmeng Mu
A high molecular weight levan was produced by a novel levansucrase and some properties of this polymer were investigated. The levan exhibited a poroid microstructure as well as series of individual ellipsoidal or spheroidal particles. The weight-average molecular weight (M¯w) of the levan was determined to be 1.41×10(8)Da. In a 0.1% solution, the levan showed a mean diameter of 176nm, while in a 1% solution the diameter was 182nm. The decomposition temperature was determined to be 216.67°C, with an endothermic peak at 147...
November 10, 2017: International Journal of Biological Macromolecules
S K Mohamed, Sh H Hegazy, N A Abdelwahab, A M Ramadan
This research aimed to synthesize natural polymer nanocomposite and employ it for coupled adsorption- photocatalytic degradation of crystal violet. Sodium alginate-g-poly (acrylic acid-co- cinnamic acid) and its composites with ZnO nanorods and graphene oxide sheets were synthesized and characterized using FT-IR, XRD, SEM, HR-TEM and DR/UV-Vis spectroscopy. The adsorption efficiency of samples for crystal violet has been studied in the dark. The effect of different parameters as pH, initial dye concentration, contact time and temperature on the adsorption efficiency of the synthesized sample has been examined...
November 10, 2017: International Journal of Biological Macromolecules
Aline Francielle Fracasso, Camila Augusto Perussello, Danielle Carpiné, Carmen Lúcia de Oliveira Petkowicz, Charles Windson Isidoro Haminiuk
The present study aimed to investigate the physical, structural and rheological modifications caused by the chemical modification process of citrus pectin. Therefore, three commercial citrus pectins with different degree of esterification were chemically modified by sequential alkali and acidic hydrolytic process to produce modified citrus pectins (MCP) with special properties. The molar mass (Mw), degree of esterification (DE), monosaccharide composition, (13)C NMR spectra, homogeneity, morphology (SEM) and rheological behavior of both native and modified citrus pectins (MCP) were investigated...
November 10, 2017: International Journal of Biological Macromolecules
Mudasir Bashir, Tuba Usmani, Sundaramoorthy Haripriya, Tanveer Ahmed
Three different exudate gums were studied for their in-vitro antioxidant activity, functional and textural properties. In-vitro antioxidant activity of the gum exudates was evaluated in terms of DPPH radical scavenging, hydroxyl radical scavenging, reducing power and phenolic content assays. Among the gum exudates, almond gum exhibited maximum DPPḢ inhibition of 35.52±1.125% followed by apricot gum and gum arabic at the concentration of 1mg/mL. Gum arabic had significantly higher reducing power than the other exudate gums...
November 10, 2017: International Journal of Biological Macromolecules
M Zuhaib Dar, Km Deepika, Kulsum Jan, Tanya L Swer, Pradeep Kumar, Ruchi Verma, Kush Verma, Kumar S Prakash, Shumaila Jan, Khalid Bashir
Effects of gamma irradiation on the physicochemical, rheological and thermal properties of the buckwheat and oat starch were studied. Results revealed that the transition temperature and enthalpy of gelatinization of starch decreased with increase in irradiation dose. Pasting properties (peak, trough, setback, pasting temperature and final viscosity) of both the starches were decreased by gamma irradiation. Gamma irradiation also resulted in the reduction in the per cent crystallinity of the starches. Apparent amylose content and swelling index decreased with increase in dose...
November 10, 2017: International Journal of Biological Macromolecules
Soyoung Son, Vijayakameswara Rao, Hyewon Ko, Sol Shin, Jueun Jeon, Hwa Seung Han, Van Quy Nguyen, Thavasyappan Thambi, Yung Doug Suh, Jae Hyung Park
In an attempt to develop the hypoxia-responsive nanoparticles for cancer therapy, a polymer conjugate, consisting of carboxymethyl dextran (CMD) and black hole quencher 3 (BHQ3), was prepared. The polymer conjugate can self-assemble into nanoparticles (CMD-BHQ3 NPs) under aqueous conditions. The anticancer drug, doxorubicin (DOX), was loaded in CMD-BHQ3 NPs to prepare DOX@CMD-BHQ3 NPs. The CMD-BHQ3 NPs released DOX in a sustained manner under physiological conditions, whereas the release rate of DOX remarkably increased under hypoxic conditions throughout the cleavage of the azo bond in BHQ3...
November 10, 2017: International Journal of Biological Macromolecules
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