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International Journal of Biological Macromolecules

Kuljit Kaur, Rajeev Jindal, Mithu Maiti, Shreya Mahajan
The morphological modification of Trapa natans starch was done by grafting the methylmethacrylate (EMA) using ferrous ammonium sulphate‑potassium persulphate as a redox initiator. Different reaction parameters such as reaction temperature, time, monomer concentration, pH and solvent were optimized to get maximum graft yield (56%). The graft copolymers thus formed were characterized by Fourier transform infrared, scanning electron microscopy, X-ray diffraction and TGA/DTA/DTG techniques. PVA/starch (N-st) composite films and PVA/N-Starch-grafted-poly (EMA) composite films were prepared separately by using glycerol as a plasticizer...
November 17, 2018: International Journal of Biological Macromolecules
Bhuvanenthiran Mutharani, Palraj Ranganathan, Shen-Ming Chen
Chitosan-gold collapse gel (CS-Au CG) was prepared by reducing chloroauric acid (HAuCl4 ) with a polysaccharide, chitosan (CS), in the absence of chemical and physical agents. CS-Au CG was used for the first time as a suitable nano-biocomposite sensing film for efficient one-step electrochemical deposition of poly (bromophenol blue) (PBPB) redox mediator through amino-hydroxyl reaction to prepare a novel anti-androgen drug flutamide (FLU) sensor using glassy carbon electrode (GCE). The effect of electropolymerization cycle, scan rate, pH, and concentration of CS-Au CG/PBPB film on electrochemical behavior of FLU molecules was investigated...
November 16, 2018: International Journal of Biological Macromolecules
Perumal Karthikeyan, Hyder Ali Thagira Banu, Sankaran Meenakshi
The present investigation was carried out for the removal of phosphate and nitrate ions from aqueous solution using lanthanum incorporated chitosan membrane (La@CS) prepared by a casting method. Systematic adsorption studies were performed by varying the influencing parameters like contact time, dosage, pH, interfering anions and temperature were optimized for the maximum phosphate and nitrate adsorption capacities. The adsorption equilibrium process was examined by Freundlich, Langmuir and Dubinin-Radushkevich isotherm models...
November 16, 2018: International Journal of Biological Macromolecules
Maryam Mohammadi, Reza Rezaei Mokarram, Marjan Ghorbani, Hamed Hamishehkar
To date, the high cost of enzyme production, lack of enzyme reusability and operational stability are the main limitations of the enzyme's application in industry. In this work, inulinase was covalently immobilized on the surface of glutathione-coated gold magnetic nanoparticles (GSH-AuMNPs). The synthesized NPs were fully characterized. The effects of different restriction factors such as substrate concentration, temperature, and pH on the performance and stability of the enzyme were examined. The maximum activity and immobilization yield were estimated 83% and 93%, respectively...
November 16, 2018: International Journal of Biological Macromolecules
R Balasubramanian, Sam Soo Kim, Jintae Lee, Jaewoong Lee
The hydrogel based composite film was prepared from k-Carrageenan (k-C), xanthan gum (X) and gellan gum (G) by solvent casting method. The transparent films made from these gellable materials with synergistic hydrogel composition have soft texture, good elasticity and excellent break strength. The k-C/X/G based nanocomposite films prepared from different weight ratio of TiO2 nanoparticles were characterized for new packaging materials. The morphology, structure and microstructure properties of the k-C/X/G and TiO2 nanocomposite films were characterized by FT-IR, XRD and SEM analysis...
November 16, 2018: International Journal of Biological Macromolecules
Bingna Cai, Peng Wan, Hua Chen, Deke Chen, Xin Chen, Huili Sun, Jianyu Pan
The proliferative activity of oyster polysaccharides in intestine epithelial cells (IEC-6) alleviated 5-fluorouracil-induced intestinal inflammation. In this study, we aimed to measure the ability of oyster polysaccharides to promote IEC-6 cell migration and antioxidant activity and further describe their cytoprotective effect on H2 O2 -challenged IEC-6 cells. The C30-60% fraction of polysaccharides (CHP2) showed rapid stimulation of IEC-6 cell migration after wounding. Then, CHP2 was fractionated into four fractions, namely, CHP2-1, CHP2-2, CHP2-3 and CHP2-4...
November 16, 2018: International Journal of Biological Macromolecules
M E Abd El-Aziz, S Morsi, Dina M Salama, M S Abdel-Aziz, Mohamed S Abd Elwahed, Essam A Shaaban, A M Youssef
Chitosan nanoparticles (CS-NPs) and chitosan/polyacrylic acid hydrogel nanoparticles (CS/PAA-HNPs) were obtained by ionic gelation with tripolyphosphate anions and copolymerization of CS with acrylic acid (AA), respectively. The prepared NPs were loaded by different concentrations of copper (1, 2 and 3% with respect to CS) to obtain chitosan/copper nanocomposites (CS/Cu-NCs) and chitosan/polyacrylic acid/copper hydrogel nanocomposites (CS/PAA/Cu-HNCs). The prepared NPs and their NCs were characterized by different techniques...
November 16, 2018: International Journal of Biological Macromolecules
Mikinori Ueno, Masato Nogawa, Rokeya Siddiqui, Koichi Watashi, Takaji Wakita, Nobuyuki Kato, Masanori Ikeda, Takasi Okimura, Shogo Isaka, Tatsuya Oda, Yasuo Ariumi
We examined the effects of various acidic polysaccharides isolated from marine algae on the infection and replication of human immunodeficiency virus type-1 (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-cell leukemia virus type-1 (HTLV-1). It was found that sulfated fucan polysaccharides, ascophyllan, and two fucoidans derived from different sources significantly inhibited the early step of HIV-1 (R9 and JR-FL) infection, while they did not affect the late step. The alginate oligomer consisted of uronic acids and sulfated-galactan porphyran showed no significant inhibitory effects...
November 16, 2018: International Journal of Biological Macromolecules
Jana Jankovicova, Petra Secova, Pavla Manaskova-Postlerova, Ondrej Simonik, Michaela Frolikova, Eva Chmelikova, Lubica Horovska, Katarina Michalkova, Katerina Dvorakova-Hortova, Jana Antalikova
Tetraspanins are multifunctional molecules located in specific microdomains on the plasma membrane. Thanks to their ability to form networks with other proteins they can participate in many cellular functions. Tetraspanins are part of the interactive network in gametes; however, their precise role in fertilization is not yet clear. The aim of this study was to compare the localization of CD9 and CD81 tetraspanins during oocyte maturation and early development of the embryos in bovine and porcine model. CD9 was detected on the oocyte plasma membrane and vesicles in the perivitelline space of bovine oocytes and embryos...
November 16, 2018: International Journal of Biological Macromolecules
Raluca Ioana Baron, Maria Bercea, Mihaela Avadanei, Gabriela Lisa, Gabriela Biliuta, Sergiu Coseri
A new approach for the preparation of poly (vinyl alcohol) (PVA) - cellulose based composite hydrogels by freezing/thawing method was conceived. We synthesized firstly the tricarboxy cellulose (OxC) (bearing three carboxyl groups in one anhydroglucose unit) using a one shot oxidation procedure and subsequently, the aqueous solutions of OxC were mixed with PVA solutions in different ratios, in the absence of any supplementary cross-linking agent. The spectral methods, FTIR, 1 H, 13 C NMR, as well as rheology measurements were used to assess the degree of interaction between the two components...
November 16, 2018: International Journal of Biological Macromolecules
Izabela Przetaczek-Rożnowska, Teresa Fortuna, Monika Wodniak, Maria Łabanowska, Paulina Pająk, Karolina Królikowska
The paper discusses how microwave radiation and mineral additives affect selected physical and chemical properties of potato starch. Potato starch was irradiated with microwaves of 440 W or 800 W and then enriched with ions of potassium, magnesium, copper, or iron. Atomic absorption spectroscopy showed an effective incorporation of ions, while mineral saturation depended on both the microwave radiation density and the element being introduced. The data obtained prove that the microwave radiation and saturation with minerals affect the rheology and thermal characteristics of the samples under examination...
November 16, 2018: International Journal of Biological Macromolecules
Stefan Arnhold, Mohamed I Elashry, Michele C Klymiuk, Sabine Wenisch
No abstract text is available yet for this article.
November 16, 2018: International Journal of Biological Macromolecules
Juan Yu, Haiyu Ji, Anjun Liu
This study investigated the effects of different temperatures on structural characterization and antitumor activity of polysaccharides from Astragalus membranaceus. APS4 and APS90 were extracted at 4 °C and 90 °C, respectively, and purified by Sephadex G-200 column. APS4-90 were obtained from APS4 after treatment at 90 °C for 6 h. MTT results showed that APS4 possessed the highest inhibitory effects on MGC-803, A549 and HepG2 cells. HPGPC analysis showed that the average molecular weights of these polysaccharides were approximately 1...
November 16, 2018: International Journal of Biological Macromolecules
Mohd Imran Khan, Anshul Mishra, Pravin K Jha, Kumar Abhishek, Rachna Chaba, Pradeep Das, Kislay K Sinha
The visceral leishmaniasis is caused by L. donovani, a neglected tropical disease with an estimated number of 500,000 cases worldwide. Apart from the absence of effective vaccine, the available drugs have limitations like toxic side effects and emergence of drug resistance. The genome of Leishmania is remarkably challenged by the oxidative stress present inside the human macrophage. To maintain genomic integrity, a number of specialized DNA repair pathways assist in the recognition and repair of damaged DNA...
November 16, 2018: International Journal of Biological Macromolecules
Shima Ghanavati Nasab, Abolfazl Semnani, Abbas Teimouri, Mehdi Javaheran Yazd, Tahereh Momeni Isfahani, Saeed Habibollahi
A novel adsorbent of chitosan/nanodiopside nanocomposite (CS-NDIO) was synthesized as a green composite for the removal of crystal violet (CV) and characterized by techniques like XRD, FT-IR, BET, and FESEM analysis. The influence of parameters like molar ratios of CS to NDIO, initial pH of the solution, dosage of adsorbent, initial concentration of CV and contact time was investigated and evaluated by central composite design (CCD; 5 levels and 4 factors). Also, Hybrid model of (ANN) model with genetic algorithm (GA) optimization was applied to the experimental data get through CCD...
November 16, 2018: International Journal of Biological Macromolecules
Ju-Yuan Bu, Wei-Ze Lv, Yi-Feng Liao, Xiao-Yu Xiao, Bao-Jun Lv
Gastric cancer (GC) is the most common gastrointestinal malignancy in the digestive system. Recent studies have proven that long non-coding RNAs (lncRNAs) are closely related to tumor growth and metastasis. The study aimed to explore the effect of LINC00978 on GC cells proliferation and tumorigenesis. LINC00978 was up-regulated in GC tissues and cell lines. Up-regulation of LINC00978 was positively correlated with low survival rate. LINC00978 silence inhibited proliferation, metastasis, and promoted apoptosis in BGC-823 cells...
November 16, 2018: International Journal of Biological Macromolecules
Kadir Erol, Büşra Koncuk Cebeci, Kazım Köse, Dursun Ali Köse
Hydrogen peroxide is converted by catalase to molecular oxygen and water to remove oxidative stress. In this study, catalase immobilization was performed using poly(2-hydroxyethyl methacrylate-glycidyl methacrylate) (poly(HEMA-GMA)) cryogels with different amounts of GMA. Catalase adsorption capacity of 298.7 ± 9.9 mg/g was achieved at the end of 9 h using the poly(HEMA-GMA)-250 cryogel. Kinetic parameters and the inhibitory effects of pesticides such as 4,4'-DDE and 4,4'-DDT on the activity of free and immobilized catalase enzyme were investigated...
November 16, 2018: International Journal of Biological Macromolecules
Yuriy A Knirel, Pavel A Ivanov, Sofiya N Senchenkova, Olesya I Naumenko, Olga O Ovchinnikova, Alexander S Shashkov, Alla K Golomidova, Vladislav V Babenko, Eugene E Kulikov, Andrey V Letarov
Escherichia coli F17 isolated from horse feces was studied in respect to the O antigen (O polysaccharide) structure and genetics. The lipopolysaccharide was isolated by phenol-water extraction of bacterial cells and cleaved by mild acid hydrolysis to yield the O polysaccharide, which was studied by sugar analysis and selective solvolysis with CF3 CO2 H along with one- and two-dimensional 1 H and 13 C NMR spectroscopy. The O polysaccharide was found to have a branched pentasaccharide repeat (O-unit) containing one residue each of d-galactose, d-mannose, l-rhamnose, d-glucuronic acid, and N-acetyl-d-glucosamine; about 2/3 units bear a side-chain glucose residue...
November 15, 2018: International Journal of Biological Macromolecules
Hong Zhang, Zhou Xiang, Xin Duan, Juan Li Jiang, Yi Ming Xing, Cheng Zhu, Qiang Song, Qin Rong Yu
In the present study, the pharmacological effects of oligosaccharides from Cistanche deserticola extract on inflammation, oxidative stress, and apoptosis in male albino rats with spinal cord injury were investigated. Lipid peroxidation, GSH, catalase, superoxide dismutase, acetylcholine esterase, GPx, ROS, and nitric acid were significantly altered in the rats with spinal cord injury. The mRNA expression levels of IL-6, TNF-α, cyclooxygenase-2, iNOS, p53, caspase-3, bax, and pro-NGF were reduced by >20% following extract supplementation...
November 15, 2018: International Journal of Biological Macromolecules
Mahboubeh Pishnamazi, Javed Iqbal, Saeed Shirazian, Gavin M Walker, Maurice N Collins
The main focus here is on the improvement of formulations utilising non-conventional bio-based excipients to improve tablet release rates. Two different formulations were considered. The first formulation contains Alcell lignin, lactose monohydrate and microcrystalline cellulose as excipients and acetylsalicylic acid (aspirin) as active pharmaceutical ingredient (API). The second formulation contains lactose monohydrate and microcrystalline cellulose as excipients and aspirin as API. The prepared formulations were roller compacted followed by milling, sieving, and tableting...
November 15, 2018: International Journal of Biological Macromolecules
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