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International Journal of Biological Macromolecules

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https://www.readbyqxmd.com/read/29331537/preparation-of-acetylated-nanofibrillated-cellulose-from-corn-stalk-microcrystalline-cellulose-and-its-reinforcing-effect-on-starch-films
#1
Li Cheng, Dongli Zhang, Zhengbiao Gu, Zhaofeng Li, Yan Hong, Caiming Li
Acetylated nanofibrillated cellulose (ANFC) with different degrees of substitution (DS) was prepared from corn-stalk microcrystalline cellulose (MCC) using chemical-mechanical combined processes. The physicochemical properties of nanofibrillated cellulose (NFC) and ANFC were investigated together with the influence of added nanoparticles on the mechanical properties of starch films. The acetylation reaction was monitored by Fourier transform infrared (FT-IR) and titration. Particle size and morphological of NFC and ANFC were studied by atomic force microscope (AFM)...
January 10, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329816/structural-polymorphism-of-a-cytosine-rich-dna-sequence-forming-i-motif-structure-exploring-ph-based-biosensors
#2
Saami Ahmed, Mahima Kaushik, Swati Chaudhary, Shrikant Kukreti
Sequence recognition and conformational polymorphism enable DNA to emerge out as a substantial tool in fabricating the devices within nano-dimensions. These DNA associated nano devices work on the principle of conformational switches, which can be facilitated by many factors like sequence of DNA/RNA strand, change in pH or temperature, enzyme or ligand interactions etc. Thus, controlling these DNA conformational changes to acquire the desired function is significant for evolving DNA hybridization biosensor, used in genetic screening and molecular diagnosis...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329815/exploring-molecular-insights-into-the-interaction-mechanism-of-cholesterol-derivatives-with-the-mce4a-a-combined-spectroscopic-and-molecular-dynamic-simulation-studies
#3
Shagufta Khan, Faez Iqbal Khan, Taj Mohammad, Parvez Khan, Gulam Mustafa Hasan, Kevin A Lobb, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan
Mammalian cell entry protein (Mce4A) is a member of MCE-family, and is being considered as a potential drug target of Mycobacterium tuberculosis infection because it is required for invasion and latent survival of pathogen by utilizing host's cholesterol. In the present study, we performed molecular docking followed by 100 ns MD simulation studies to understand the mechanism of interaction of Mce4A to the cholesterol derivatives and probucol. The selected ligands, cholesterol, 25-hydroxycholesterol, 5-cholesten-3β-ol-7-one and probucol bind to the predicted active site cavity of Mce4A, and complexes remain stable during entire simulation of 100 ns...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329814/interaction-between-structurally-different-heteroexopolysaccharides-and-%C3%AE-lactoglobulin-studied-by-solution-scattering-and-analytical-ultracentrifugation
#4
Sanaullah Khan, Johnny Birch, Marie-Rose Van Calsteren, Richard Ipsen, Günther H J Peters, Birte Svensson, Pernille Harris, Kristoffer Almdal
Despite a very large number of bacterial exopolysaccharides have been reported, detailed knowledge on their molecular structures and associative interactions with proteins is lacking. Small-angle X-ray scattering, dynamic light scattering and analytical ultracentrifugation (AUC) were used to characterize the interactions of six lactic acid bacterial heteroexopolysaccharides (HePS-1-HePS-6) with β-lactoglobulin (BLG). Compared to free HePSs, a large increase in the X-ray radius of gyration RG, maximum length L and hydrodynamic diameter dH of HePS-1-HePS-4 mixed with BLG revealed strong aggregation, the extent of which depended on the compact conformation and degree of branching of these HePSs...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329813/effects-of-metal-ions-in-tea-polysaccharides-on-their-in-vitro-antioxidant-activity-and-hypoglycemic-activity
#5
Minghao Fan, Xun Sun, Yilin Qian, Ying Xu, Dongfeng Wang, Yanping Cao
Total tea polysaccharides (TTPS) were extracted from two kinds of pruning leaves of tea plant and fractionated into neutral tea polysaccharides (TPSI) and acidic tea polysaccharides (TPSII) by anion exchange resin D315. Some physicochemical properties, including structure, monosaccharide composition, and molecular weight distribution, as well as the 4 in vitro antioxidant activities and inhibitory effects on α-glucosidase of above polysaccharides before and after removing metal ions were investigated. By comparing TTPS and TPSII, we found that they exhibited different antioxidant activities and inhibitory actions against α-glucosidase after their metal ions were removed...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329812/synergistic-effect-of-polysaccharides-betalain-pigment-and-phenolic-compounds-of-red-prickly-pear-opuntia-stricta-in-the-stabilization-of-salami
#6
Nadia Kharrat, Hedia Salem, Aicha Mrabet, Fatma Aloui, Soumaya Triki, Ahmed Fendri, Youssef Gargouri
The aim of this work is to try to substitute some synthetic additives by a natural extract from red prickly pear (Opuntia stricta) which known by its richness on bioactive polysaccharides mainly consisting of galactose, rhamnose and galacturonic acid. This natural fruit has a high content of carbohydrates above 18.81% FM. It contains also a high level of polyphenols 152.25 ± 0.26 μg QE/mg PPE and flavonoids about 370.60 ± 0.12 μg GAE/mg of PPE. In addition, prickly pear extract (PPE) displayed a strong antioxidant and antimicrobial activities...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329811/cardioprotection-activity-and-mechanism-of-astragalus-polysaccharide-in-vivo-and-in-vitro
#7
Debin Liu, Lei Chen, Jianye Zhao, Kang Cui
Astragalus polysaccharides (ASP) is extracted from Astragalus, and is the main active ingredient of Astragalus membranaceus. The purpose of this study was to investigate the protective effect of ASP on rat cardiomyocytes damage induced by myocardial ischemia and reperfusion injury (MVRI) and isoprenaline(ISO) in vivo and in vitro. The model of cardiomyocytes damage was induced using MVRI in a rat in vivo and also using ISO in cell. After ASP intervention, the protective effect of ASP on cardiomyocytes was evaluated by animal experimental and cell experimental...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329810/facile-microencapsulation-of-olive-oil-in-porous-starch-granules-fabrication-characterization-and-oxidative-stability
#8
Miao Lei, Fang-Cheng Jiang, Jie Cai, Si Hu, Rui Zhou, Gang Liu, Yue-Hui Wang, Hai-Bo Wang, Jing-Ren He, Xin-Gao Xiong
In this study, starch with porous structures derived from purple sweet potato was prepared and used as a food-grade polymer for the microencapsulation of olive oil. The optimal reaction conditions for preparing porous starch were determined to improve its adsorption capacity as effective microcapsule-wall materials. Olive oil was then impregnated in microspheres, and loading ratio was optimized by investigating the restrictive factors, including the mass ratio of olive oil to porous starch, as well as the embedding temperature and time...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329809/new-n-guanidinium-chitosan-silica-ionic-microhybrids-as-efficient-adsorbent-for-dye-removal-from-waste-water
#9
Ahmed Salama, Peter Hesemann
N-guanidinium chitosan acetate, a new chitosan derivative, was prepared via direct guanylation reaction between chitosan and cyanamide in the presence of scandium (III) triflate. Treatment of N-guanidinium chitosan acetate with 3-(trihydroxysilyl)-1-propanesulphonic acid followed by sol-gel reaction allowed accessing N-guanidinium chitosan silica hybrid material. The new ionic microhybrid was characterized using 13C and 29Si solid state NMR, IR spectroscopy, scanning electron microscopy and thermogravimetry...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329808/structural-and-energetic-basis-for-the-molecular-recognition-of-dual-synthetic-vs-natural-inhibitors-of-egfr-her2
#10
Bello Martiniano, Saldaña-Rivero Lucia, Correa-Basurto José, García Benjamín, Sánchez-Espinosa Víctor Armando
Activation of EGFR starts by ligand binding at the extracellular domain which results in homo and heterodimerization, leading to phosphorylation, activation of downstream signaling pathways which upregulate expression of genes, proliferation and angiogenesis. Abnormalities in the expression of EGFR play a critical role in the development of different types of cancer. HER2 is the preferred heterodimerization partner for EGFR; this biological characteristic together with the high percentage of structural homology has been exploited in the design of dual synthetic inhibitors against EGFR/HER2...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329807/nasal-adhesive-patches-approach-for-topical-application-for-dry-nasal-syndrome
#11
Flavia Laffleur
This present study intended to provide nasal adhesive formulations for the topical treatment of dry nasal syndrome. Mucoadhesive films were prepared according to solvent evaporation method consisting of well-known polymers such as gellan and carboxymethyl cellulose. Mucoadhesive films (A-E) were evaluated in respect to their physicochemical properties, stability, disintegration behavior and tensile strength. Moreover, uptake capacity of adhesive films was investigated according to three assays vapor uptake/ permeability and water uptake...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329806/effect-of-different-animal-fat-and-plant-oil-additives-on-physicochemical-mechanical-antimicrobial-and-antioxidant-properties-of-chitosan-films
#12
Lalehan Akyuz, Murat Kaya, Sedef Ilk, Yavuz Selim Cakmak, Asier M Salaberria, Jalel Labidi, Bahar Akyuz Yılmaz, Idris Sargin
Practical application of chitosan-essential oil blend films is limited due to the uneconomical extraction procedure of essential oils from plants. This study aimed to produce chitosan films blended with low cost and commercially available oils and fats consumed in daily human diet (olive, corn and sunflower oils, butter and animal fats). The study also focused on how physicochemical, biological and mechanical properties of chitosan blend films were influenced by the incorporation of oils and fats with varying unsaturation degrees...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329805/preparative-expression-and-purification-of-a-nacreous-protein-n16-and-testing-its-effect-on-osteoporosis-rat-model
#13
Zhen-Yan Xu, Yu-Ling Liu, Jia-Bi Lin, Ke-Ling Cheng, Yong-Gang Wang, Hong-Liang Yao, Wei-Peng, Hoi-Yan Wu, Wei-Wei Su, Pang-Chui Shaw, Pei-Bo Li
N16, a nacreous protein isolated from Pinctada martensii, is related to nacreous layer formation. Our previous study indicated that N16 showed dual regulatory effects by inducing osteoblast biomineralization as well as inhibiting osteoclast formation. In order to obtain large quantity of N16 for animal experiment and clinical trial, a fermentation and preparative purification method was established. The N16 cDNA was cloned to a BL21(DE3)plysE-pET32a vector and grown in a 20 L fermenter. The medium, temperature, pH and dissolved oxygen (DO) were optimized...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325748/cranberry-proanthocyanidin-chitosan-hybrid-nanoparticles-as-a-potential-inhibitor-of-extra-intestinal-pathogenic-escherichia-coli-invasion-of-gut-epithelial-cells
#14
Emilia Alfaro-Viquez, Daniel Esquivel-Alvarado, Sergio Madrigal-Carballo, Christian G Krueger, Jess D Reed
Chitosan interacts with proanthocyanidins through hydrogen-bonding, which allows encapsulation and development of stable nanoparticles via ionotropic gelation. Cranberry proanthocyanidins (PAC) are associated with the prevention of urinary tract infections and PAC inhibit invasion of gut epithelial cells by extra-intestinal pathogenic Escherichia coli (ExPEC). We determined the effect of cranberry proanthocyanidin-chitosan hybrid nanoparticles (PAC-CHTNp) on the ExPEC invasion of gut epithelial cells in vitro...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325747/synthesis-characterization-of-novel-chitosan-based-water-dispersible-polyurethanes-and-their-potential-deployment-as-antibacterial-textile-finish
#15
Noureen Arshad, Khalid Mahmood Zia, Farukh Jabeen, Muhammad Naveed Anjum, Nadia Akram, Mohammad Zuber
Our current research work comprised of synthesis of a series of novel chitosan based water dispersible polyurethanes. The synthesis was carried out in three steps, in first step, the NCO end capped PU-prepolymer was formed through the reaction between Polyethylene glycol (PEG) (Mn = 600), Dimethylolpropionic acid (DMPA) and Isophorone diisocyanate (IPDI). In second step, the neutralization step was carried out by using Triethylamine (TEA) which resulted the formation of neutralized NCO terminated PU-prepolymer, after that the last step chain extension was performed by the addition of chitosan and followed the formation of dispersion by adding calculated amount of water...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325746/first-report-of-the-characterization-of-a-snake-venom-apyrase-ruviapyrase-from-indian-russell-s-viper-daboia-russelii-venom
#16
Bhargab Kalita, Aparup Patra, Shagufta Jahan, Ashis K Mukherjee
A novel apyrase from Russell's viper venom (RVV) was purified and characterized, and it was named Ruviapyrase (Russell's viper apyrase). It is a high molecular weight (79.4 kDa) monomeric glycoprotein that contains 2.4% neutral sugars and 58.4% N-linked oligosaccharides and strongly binds to Concanavalin A. The LC-MS/MS analysis did not identify any protein in NCBI protein database, nevertheless some de novo sequences of Ruviapyrase showed putative conserved domain of apyrase superfamily. Ruviapyrase hydrolysed adenosine triphosphate (ATP) to a significantly greater extent (p < ...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325745/chitosan-nanoparticles-cellulose-nanocrystals-nanocomposites-as-a-carrier-system-for-the-controlled-release-of-repaglinide
#17
Wafaa S Abo Elseoud, Mohammad L Hassan, Magdy W Sabaa, Mona Basha, Enas A Hassan, Shaimaa M Fadel
The aim of the present work was to study the use of cellulose nanocrystals (CNC) and chitosan nanoparticles (CHNP) for developing controlled-release drug delivery system of the anti-hyperglycemic drug Repaglinide (RPG). CNC was isolated from palm fruit stalks by sulfuric acid hydrolysis; the dimensions of the isolated nanocrystals were 86-237 nm in length and 5-7 nm in width. Simple and economic method was used for the fabrication of controlled release drug delivery system from CNC and CHNP loaded with RPG drug via ionic gelation of chitosan in the presence of CNC and RPG...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325744/dextran-hydrogels-by-crosslinking-with-amino-acid-diamines-and-their-viscoelastic-properties
#18
Naphtali A O'Connor, Mihaela Jitianu, Greisly Nunez, Quentin Picard, Madeline Wong, David Akpatsu, Adam Negrin, Rajendra Gharbaran, Daniel Lugo, Sundus Shaker, Andrei Jitanu, Stephen Redenti
Amine functionalized polysaccharide hydrogels such as those based on chitosan are widely examined as biomaterials. Here we set out to develop a facile procedure for developing such hydrogels by crosslinking dextran with amino acid diamines. The dextran-amino acid gels were formed by the addition of the amino acid diamines to a dextran and epichlorohydrin solution once it became homogeneous. This was demonstrated with three amino acid diamines, lysine, lysine methyl ester, and cystine dimethyl ester. Hydrogel networks with albumin entrapped were also demonstrated...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325743/total-fractionation-and-characterization-of-the-water-soluble-polysaccharides-isolated-from-enteromorpha-intestinalis
#19
REVIEW
Xia Li, Feng Xiong, Yufeng Liu, Feifei Liu, Zaibin Hao, Huiying Chen
Water-soluble crude polysaccharides (WE) were extracted from the Enteromorpha intestinalis with hot water and further fractionated on a DEAE-52 Cellulose chromatography column and Sepharose CL-6B gel-permeation chromatography to afford one neutral fraction (WE-11) and five acidic fractions (WE-21, WE-31, WE-32, WE-41 and WE-42). Monosaccharide analysis showed that WE-32, WE-41 and WE-42 were all composed of Rha and GlcA, WE-21 and WE-31 contained Man and Rha, and WE-11 was composed of GlcA and Xyl. The molecular weight of WE-11, WE-21, WE-31 WE-32, WE-41 and WE-42 were 2...
January 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29325742/mutation-of-the-conserved-g66-residue-in-gs-region-decreased-structural-stability-and-activity-of-arginine-kinase
#20
Qing-Yun Wu, Yuan-Yuan Zhu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Xiao-Yun Wang, Kai-Lin Xu
Arginine kinase (AK) catalyzes the reversible phosphorylation of arginine by ATP, yielding the phosphoarginine. Amino acid residues in the guanidine specificity (GS) region play important roles in the guanidine-recognition. However, little is known about roles of amino acid residue G66 in the GS region in proteins folding, activity and structural stability. In this study, a series of G66 mutations were constructed to investigate its roles in AK's structural stability and activity. Our studies revealed that mutations in this conserved site could cause pronounced loss of activity, conformational changes and structural stability...
January 8, 2018: International Journal of Biological Macromolecules
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