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International Journal of Biological Macromolecules

Ronny G Huamani, Christian R Jacinto, Hugo Alarcón, Ily M Mejía, Rosario C López, Denise O Silva, Eder T G Cavalheiro, Tiago- Venâncio, Juan Z Dávalos, Ana C Valderrama
It has been synthesized, characterized and tested a new biomaterial AlgS (sodium alginate functionalized with cysteine) to remove Pb(II) in aqueous media. The maximum Pb(II)-sorption capacity of AlgS (Qmax  = 770 mg·g-1 ) is between almost two and nine times higher than other alginate-materials reported in the literature. Techniques, such as TGA/DSC, SEM/EDS, BET, FTIR, UV-Vis, XRD and 13 C solid state-NMR have been used to study the chemical-modification of alginate at oxidation and aminofication stages...
September 18, 2018: International Journal of Biological Macromolecules
Yifan Wang, Yanhua Hou, Yatong Wang, Zongbao Lu, Chi Song, Yifeng Xu, Nana Wei, Quanfu Wang
Peroxiredoxin (Prx, EC is a family of the thiol-dependent antioxidant enzyme. In this study, a cold-adapted Prx gene from Antarctic psychrophilic bacterium Psychrobacter sp. ANT206 (PsPrx) consisted of an open reading frame (ORF) of 567 bp was cloned. Amino acid sequence analysis revealed that PsPrx contained one catalytic site (Thr45, Cys48 and Arg121) and could be categorized as a typical 2-Cys Prx. Compared with the mesophilic StPrx, PsPrx with a reduced amount of hydrogen bonds and salt bridges and other characteristics, may be responsible for its enzymatic stability and flexibility at low temperature...
September 18, 2018: International Journal of Biological Macromolecules
Alexander M Matyushenko, Natalia A Koubassova, Daniil V Shchepkin, Galina V Kopylova, Salavat R Nabiev, Larisa V Nikitina, Sergey Y Bershitsky, Dmitrii I Levitsky, Andrey K Tsaturyan
Tropomyosin (Tpm) plays a crucial role in the regulation of muscle contraction by controlling actin-myosin interaction. Tpm coiled-coil molecules bind each other via overlap junctions of their N- and C-termini and form a semi-rigid strand that binds the helical surface of an actin filament. The high bending stiffness of the strand is essential for high cooperativity of muscle regulation. Point mutations M8R and K15N in the N-terminal part of the junction and the A277V one in the C-terminal part are associated with dilated cardiomyopathy, while the M281T and I284V mutations are related to hypertrophic cardiomyopathy...
September 18, 2018: International Journal of Biological Macromolecules
Yan Huang, Yu Liu, Xiao-Yu Zhu, Zhao-Zhe Xin, Hua-Bin Zhang, Dai-Zhen Zhang, Jia-Lian Wang, Bo-Ping Tang, Chun-Lin Zhou, Qiu-Ning Liu, Li-Shang Dai
The mitochondrial genome (mitogenome) plays an important role in revealing molecular evolution. In this study, the complete mitogenome of Grammodes geometrica (G. geometrica) (Lepidoptera: Erebidae) was sequenced and characterized. The nucleotide composition of the genome is highly A + T biased, accounting for 80.49%. Most protein-coding genes (PCGs) are initiated by ATN codons except for the cytochrome oxidase subunit 1 (cox1) gene, which was initiated by CGA. The order and orientation of genes with the order trnM-trnI-trnQ-nad2 is a typical rearrangement compared with that ancestral insects in which trnM is located between trnQ and nad2...
September 18, 2018: International Journal of Biological Macromolecules
Pei Chen, Hui-Ping Liu, Hai-Hu Ji, Na-Xin Sun, Ying-Ying Feng
Grifola frondosa is a widely eaten and medicinal fungus. In this study, we extracted a cold-water-soluble polysaccharide from Grifola frondosa (cGFP) and investigated its effects on the proliferation and apoptosis of human hepatoma HepG2 cells. MTT assay showed that cGFP induced apoptosis of HepG2 cells in a dose-dependent manner. Flow cytometry analysis showed that cGFP induced apoptosis in HepG2 cells through S phase arrest. The distribution of cells at different apoptotic stages was determined by Annexin V-FITC and Propidium Iodide (PI) staining...
September 17, 2018: International Journal of Biological Macromolecules
Xiaoyan Zhao, Hongkai Liu, Xiaowei Zhang, Haitao Zhu
The effects of different extraction methods on the contents of disulfide (SS) and sulfhydryl (SH) and secondary structure of albumin, globulin, prolamin and glutelin fractions from walnut proteins were evaluated. By comparison with the changing trend for four protein fractions from alkali extraction with isoelectric precipitation (AEIP), the SH contents of globulin, prolamin and glutelin fractions from the reverse micelles (RMs) significantly increased (p < 0.05), but decreased in the albumin faction...
September 17, 2018: International Journal of Biological Macromolecules
A M Omer, R E Khalifa, Zhaohong Hu, Hong Zhang, Chao Liu, Xiao-Kun Ouyang
In this study, an innovative adsorbent based on tetraethylenepentamine (TEPA) functionalized alginate (Alg) beads (TEPA-Alg) was developed for the adsorptive removal of Cr (VI) from aqueous solutions. Chemical modification of alginate surface was carried out using p-benzoquinone (PBQ) as a coupling agent followed by functionalization with TEPA. The prepared functionalized beads were characterized using FTIR, TGA, SEM, and XPS tools. Results showed that the ion exchange capacity (IEC) significantly increased from 6...
September 17, 2018: International Journal of Biological Macromolecules
Farouk Benaceur, Hicham Gouzi, Boumediene Meddah, Aref Neifar, Ali Guergouri
Catechol oxidase (PPO) was extracted and purified from Tadela (Phoenix dactylifera L.) date fruit, by a procedure that included (NH4 )2 SO4 precipitation followed by dialysis, Q-Sepharose bb ion-exchange chromatography and HPLC gel filtration chromatography. Some of its biochemical characteristics were studied. The purification rate and the yield were 80% and 20%, respectively. The Tadela date fruit catechol oxidase exhibited a molecular weight of 90 kDa using SDS-PAGE. The catechol oxidase showed only o‑diphenolase and triphenolase activities while no monophenolase activity was detected...
September 17, 2018: International Journal of Biological Macromolecules
Lijie Wei, Yingqi Mi, Jingjing Zhang, Qing Li, Fang Dong, Zhanyong Guo
Chemical modification is one of the prominent methods used to improve the water solubility and bioactivity of chitosan. In this paper, a series of quaternary ammonium chitosan derivatives based on 6-O-chloroacetylated chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FT-IR, 1 H NMR spectroscopy, and elemental analysis. Furthermore, the antifungal activity against Botrytis cinerea, Gibberella zeae, and Physalospora piricola Nose was estimated using in vitro hypha measurements...
September 17, 2018: International Journal of Biological Macromolecules
Reza Monfared-Asl
Today, find a good and effective drug for improving the incidence of Alzheimer disease (AD) is a major concern among scientists. Many researchers have recently targeted curcumin, a yellow powder from Curcuma longa, as the useful source of anti-Alzheimer agent. Though this compound widely used since ancient times as food color and/or additive, currently some researchers believed that this compound can treat AD-affected brains. However, the accurate mechanism of action of curcumin is the treatment of AD is obscure...
September 17, 2018: International Journal of Biological Macromolecules
Lin Xin, Li-Qiang Zhou, Li Liu, Yi-Wu Yuan, Hou-Ting Zhang, Fei Zeng
BACKGROUND: Gastric cancer (GC) severely threatens human life, and METase seemed to inhibit tumor growth. However, the potential mechanism underlying it is still unclear. METHODS: Both clinical tissues and cell lines were used in the present study. SNHG5 and miR-20a expressions were determined using real-time PCR. Western blot was performed to determine the expression of autophagy-related proteins. The interaction between miR-20a and SNHG5 was determined using luciferase reporter assay and RNA immunoprecipitation (RIP)...
September 15, 2018: International Journal of Biological Macromolecules
Priyanka P Patil, Raghvendra A Bohara, Jagruti V Meshram, Shivdas G Nanaware, Shivaji H Pawar
The hybrid chitosan-ZnO nanoparticles (C@ZnO NPs) are synthesized and coated on Silk fibroin-polyvinyl alcohol (SF-PVA) composite film by a sonochemical coating process. These are systematically studied for their synergistic antibacterial activity and reported. The coated composite films show the excellent antibacterial activity against Gram-positive and Gram-negative bacteria. The composite films are characterized by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) studies...
September 15, 2018: International Journal of Biological Macromolecules
Ravindran Keppanan, Patcharin Krutmuang, Sivaramakrishnan Sivaperumal, Mubasher Hussain, Bamisope Steve Bamisile, Luis Carlos Ramos Aguila, Chandra Kanta Dash, Liande Wang
Entomopathogenic fungi based microbial insecticides are considered as safe alternatives to chemical pesticides, which secretes several bioactive compounds to kill the host insects. In this study, we report a new approach for the synthesis and characterization of insecticide toxic protein IF8 produced by the Isaria fumosorosea 08, and to evaluate the mycotoxin level against the vector of Huanglongbing (HLB) or citrus greening disease, the Asian citrus psyllid, Diaphorina citri. Soluble toxic metabolites extracted from I...
September 15, 2018: International Journal of Biological Macromolecules
Qiang Li, Qiangfeng Wang, Xin Jin, Zuqin Chen, Chuan Xiong, Ping Li, Jian Zhao, Wenli Huang
Hygrophorus russula (Schaeff.) Kauffman is an edible ectomycorrhizal fungus that is widely distributed in the world. In this study, the mitogenome of H. russula was sequenced and assembled. The mitogenome of H. russula is composed of circular DNA molecules, with a total size of 55,769 bp. Further analysis indicated that the frequent use of A and T in codons contributes to the high AT content (80.87%) in the H. russula mitogenome. Comparative analysis indicated that the length and base composition of the core protein-encoding genes, and the number of tRNA genes in the H...
September 15, 2018: International Journal of Biological Macromolecules
Wenhui Yi, Ping Zhang, Jin Hou, Weiping Chen, Lei Bai, Sweejiang Yoo, Asif Khalid, Xun Hou
A lentinan (LEN) functionalized multi-walled carbon nanotubes (MWCNTs) drug delivery system, using tamoxifen (TAM) as a model anticancer agent, was developed by a simple non-covalent approach. This developed system (MWCNTs-TAM-LEN) possessed good stability, water dispersibility and extraordinary photothermal properties. It was demonstrated by the in vitro experiments that MWCNTs-TAM-LEN had enhanced cellular uptake, antitumor activity and cell apoptosis on Mcf-7 cells in comparison with TAM and MWCNTs-TAM. The cell inhibition rate and apoptosis rate of Mcf-7 cells treated by MWCNTs-TAM-LEN with near-infrared (NIR) were 67...
September 15, 2018: International Journal of Biological Macromolecules
Abdulrahman L Al-Malki
This study investigated the impact of Shikimic Acid (SA) obtained from leaves of Artemisia absinthium on protein glycation in the retina of diabetic rats. The GC/MS analysis of A. absinthium showed that the most abundant bioactive compound was SA (C7 H10 O5 ) with a measured retention Index (RI) of 1960 compared to that of the reference sample (1712). Male albino rats were divided into two main groups, Group I (control) and Group II (diabetic); Group II was further divided into four subgroups: Group IIa (diabetic control), Group IIb (diabetic rats were given SA orally [50 mg/kg, body weight (bw)/day], Group IIc diabetic rats were given SA orally [100 mg/kg, bw/day], and Group IId (diabetic rats were given metformin orally [100 mg/kg, bw/day] as positive control)...
September 15, 2018: International Journal of Biological Macromolecules
Youyang Qu, Jingling Tang, Li Liu, LiLi Song, Simin Chen, Yanan Gao
Myocardial infarction (MI) continues to be a major contributor to the morbidity and mortality across the globe. Injectable hydrogel, a tissue-engineered scaffold, recently demonstrated very promising in myocardial repair. However, the undesirable retention and survival of transplanted cells has limited their applications due to the oxidative stress microenvironment of MI lesions. In this work, a thermosensitive α-tocopherol (AT) liposome loaded chitosan hydrogel was developed to suppress the oxidative stress injury in cardiomyocytes...
September 15, 2018: International Journal of Biological Macromolecules
Mohamed Abdulhamid Ganim, Mehmet Cengiz Baloglu, Aysenur Aygun, Yasemin Celik Altunoglu, Hakan Sezgin Sayiner, Fatma Kandemirli, Fatih Sen
Isatin, thiosemicarbazone and their derivatives have been widely used in biological applications such as antimicrobial, antiviral and anticancer therapies. Herein, eight isatin and thiosemicarbazone derivative compounds were re-synthesized and evaluated for DNA binding analysis including DNA protection studies using plasmid DNA (pUC19) and DNA interaction experiments using calf thymus DNA (CT-DNA). All compounds were also utilized in vitro assay to assess the antimicrobial activity of compounds against different pathogenic bacterial strains...
September 15, 2018: International Journal of Biological Macromolecules
Mehak Gulzar, Sunayana Begum Syed, Faez Iqbal Khan, Parvez Khan, Shahid Ali, Gulam Mustafa Hasan, Pankaj Taneja, Md Imtaiyaz Hassan
Integrin-linked kinase (ILK) is a member of Ser/Thr kinase which interacts to the cytoplasmic domain of β-integrins, and thereby induces apoptosis. ILK is considered as potential drug target because it's direct involvement in the tumor progression. Here, we have performed molecular docking followed by 100 ns MD simulation to understand the mechanism of interaction of ILK with the ellagic acid (EA). EA is well known for its antiproliferative and antioxidant properties in cancer cell lines and animal models...
September 15, 2018: International Journal of Biological Macromolecules
Pankaj Kumar Pandey, Priyanka Kaushik, Kamla Rawat, H B Bohidar
Complex coacervation was noticed between in situ formed protein (a primarily hydrophobic Zein protein with pI = 6.2) nanoparticles (size 80-120 nm) and ds-DNA (a high charge density polyanion), in the ionic liquid (IL) solutions of 1-ethyl-3-methyl imidazolium chloride [C2mim][Cl], and 1-octyl-3-methyl imidazolium chloride [C8mim][Cl], in the studied ionic strength range of I = 10-4 to 6 × 10-1  M, which was extended to strong monovalent 1:1 electrolyte (NaCl) to explore the commonality between the organic and inorganic salt (ionic) environment on coacervation...
September 15, 2018: International Journal of Biological Macromolecules
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