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Journal of Infection

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https://www.readbyqxmd.com/read/30659857/evaluation-of-next-generation-sequencing-for-the-pathogenic-diagnosis-of-children-brain-abscesses
#1
LETTER
Hui-Li Hu, Ling-Yun Guo, Hong-Long Wu, Wen-Ya Feng, Tian-Ming Chen, Gang Liu
In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer unbiased sequencing and rapid diagnosis of causative pathogens, moreover, it could detect multiple pathogenic microorganisms from abscess samples. In our study, Fusobacterium nucleatum, and Streptococcus intermedius or combinations of them were found in 3/4 of polymicrobial brain abscesses. Internal organ abscesses are illustrative of the shortcomings of bacterial culture...
January 16, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30659856/hepatitis-e-virus-genotype-3-and-capsid-protein-in-the-blood-and-urine-of-immunocompromised-patients
#2
Olivier Marion, Nicolas Capelli, Sebastien Lhomme, Martine Dubois, Mélanie Pucelle, Florence Abravanel, Nassim Kamar, Jacques Izopet
OBJECTIVES: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients. METHODS: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. RESULTS: Urinary HEV RNA was detected in 12 (50%) of the 24 transplanted patients diagnosed with HEV hepatitis...
January 16, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30658081/vertically-acquired-occult-hepatitis-b-virus-infection-may-become-overt-after-several-years
#3
Anders Eilard, Maria Andersson, Johan Ringlander, Rune Wejstål, Gunnar Norkrans, Magnus Lindh
OBJECTIVES: To investigate the frequency of vertically acquired occult hepatitis B virus (HBV) infection (OBI). METHODS: We investigated 44 children born to hepatitis B surface antigen (HBsAg) positive mothers. They received HBV vaccine directly after birth and at 2, 6 and 52 weeks of age; eight with HBeAg-positive mothers also received hepatitis B immunoglobulin (HBIG). HBV DNA was analyzed in blood collected at 6 weeks and 12 months of age, and HBV antibodies at 12 and 18 months of age...
January 15, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30658080/decrease-of-methicillin-resistance-in-staphylococcus-aureus-in-nosocomial-infections-in-germany-a-prospective-analysis-over-10-years
#4
T S Kramer, C Schröder, M Behnke, S J Aghdassi, C Geffers, P Gastmeier, C Remschmidt
OBJECTIVES: Methicillin resistant Staphylococcus aureus (MRSA) remains an important cause of healthcare-associated infections. Here, we describe the development of methicillin-resistant isolates among nosocomial Staphylococcus aureus (SA) infections in Germany between 2007 and 2016. METHODS: We analyzed data from the voluntary German national nosocomial Infection Surveillance System. Data on bloodstream infections (BSI) and lower respiratory tract infections (LRTI) were derived from intensive care units (ICU), whereas data on surgical site infections (SSI) were collected from surgical departments (SD)...
January 15, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30658079/diagnosing-urinary-tract-infection-in-older-people
#5
LETTER
Henry John Woodford
No abstract text is available yet for this article.
January 15, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30653985/inhibition-of-autophagy-protects-against-sepsis-by-concurrently-attenuating-the-cytokine-storm-and-vascular-leakage
#6
Liang-Hsuan Lu, Chiao-Hsuan Chao, Trai-Ming Yeh
OBJECTIVES: Sepsis is an overwhelming systemic inflammatory response for which no satisfactory therapeutic drug is available. Previous studies have shown that autophagy is involved in the cytokine storm and vascular leakage that occur during sepsis. Therefore, we aimed to evaluate the therapeutic potential of autophagy inhibitors against bacterial infection-induced sepsis. METHODS: Cytokine production and phagocytosis of bacteria by human leukocytes and the permeability of endothelial cells were determined after the co-incubation of cells with lipopolysaccharide (LPS) or Escherichia coli in the presence or absence of autophagy inhibitors in vitro...
January 14, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30653984/public-health-outcome-of-tuberculosis-cluster-investigations-england-2010-2013
#7
E L Hamblion, A Burkitt, M K Lalor, L F Anderson, H L Thomas, I Abubakar, S Morton, H Maguire, S R Anderson
OBJECTIVES: Tuberculosis(TB) is a serious re-emergent public health problem in the UK. In response to rising case incidence a National TB Strain-Typing Service based on molecular strain-typing was established. This facilitates early detection and investigation of clusters, targeted public health action, and prevention of further transmission. We review the added public health value of investigating molecular TB strain-typed(ST) clusters. METHODS: A structured questionnaire for each ST cluster investigated in England between 1 January 2010 and 30 June 2013 was completed...
January 14, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30629960/the-clinical-significance-of-thrombocytopenia-complicating-sepsis-a-meta-analysis
#8
LETTER
Yun Xie, Rui Tian, Hui Xie, Wei Jin, Jiang Du, Peijie Huang, Zhigang Zhou, Ruilan Wang
No abstract text is available yet for this article.
January 7, 2019: Journal of Infection
https://www.readbyqxmd.com/read/30550819/detection-of-pediatric-bacterial-meningitis-pathogens-from-cerebrospinal-fluid-by-next-generation-sequencing-technology
#9
LETTER
Ling-Yun Guo, Yong-Jun Li, Lin-Lin Liu, Hong-Long Wu, Jia-Li Zhou, Ye Zhang, Wen-Ya Feng, Liang Zhu, Bing Hu, Hui-Li Hu, Tian-Ming Chen, Xin Guo, He-Ying Chen, Yong-Hong Yang, Gang Liu
No abstract text is available yet for this article.
December 12, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30528872/mortality-risk-factors-for-listeriosis-a-10-year-review-of-non-pregnancy-associated-cases-in-england-2006-2015
#10
Antonia Scobie, Sanch Kanagarajah, Ross J Harris, Lisa Byrne, Corinne Amar, Kathie Grant, Gauri Godbole
Listeriosis is a foodborne illness that can result in septicaemia, Central Nervous System (CNS) disease, foetal loss and death in high risk patients. OBJECTIVES: To analyse the demographic trends, clinical features and treatment of non-perinatal listeriosis cases over a ten year period and identify mortality-associated risk factors. METHODS: Reported laboratory-confirmed non-pregnancy associated cases of listeriosis between 2006 and 2015 in England were included and retrospectively analysed...
December 5, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30528871/differential-t-cell-responses-against-dosr-associated-antigen-rv2028c-in-bcg-vaccinated-populations-with-tuberculosis-infection
#11
Hui-Min Zhao, Rui Du, Chun-Ling Li, Ping Ji, Hai-Cong Li, Kang Wu, Zhidong Hu, Shui-Hua Lu, Douglas B Lowrie, Xiao-Yong Fan
The IFN-γ release assays (IGRAs) based on region of difference 1 (RD1) antigens have improved diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs with these antigens could not distinguish latent tuberculosis infection (LTBI) from active tuberculosis (ATB). DosR regulon genes are thought to be important for Mtb dormancy, and their products have higher immunogenicity in LTBI than ATB individuals, suggesting protective immunity mediated by DosR regulon-encoded antigens and potential utility of them for differential diagnostics of Mtb-infected populations or development of therapeutic vaccines against tuberculosis (TB)...
December 5, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30528870/severe-periodontitis-is-more-common-in-hiv-infected-patients
#12
Hester Groenewegen, Wouter F W Bierman, Konstantina Delli, Pieter U Dijkstra, Willem Nesse, Arjan Vissink, Frederik K L Spijkervet
OBJECTIVE: To assess periodontitis prevalence and severity in HIV infected patients as compared to controls. Furthermore, to assess whether HIV infection characteristics are associated with periodontitis. DESIGN: cross-sectional controlled study. METHODS: We assessed prevalence and severity of periodontitis in 258 HIV-infected patients and 539 historical controls with the Dutch Periodontal Screening Index (DPSI). HIV characteristics were collected from medical charts...
December 5, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30528869/diagnostic-performance-of-plasma-cytokine-biosignature-combination-and-mcp-1-as-individual-biomarkers-for-differentiating-stages-of-mycobacterium-tuberculosis-infection
#13
Jie Luo, Mingxu Zhang, Baosong Yan, Fake Li, Shaonian Guan, Kai Chang, Wenbin Jiang, Huan Xu, Tao Yuan, Ming Chen, Shaoli Deng
OBJECTIVE: We aimed to identify plasma cytokine biomarkers that differentiate the infection stages of Mycobacterium tuberculosis (MTB). METHODS: This study included a total of 227 subjects consisting of active tuberculosis (ATB) patients, latent tuberculosis infection (LTBI) individuals, and healthy controls (HC). We analyzed the expressions of 38 plasma cytokines in the discovery cohort to identify the biosignatures for differentiating MTB infection states, area under the curve (AUC) were used to evaluate the diagnostic efficiency...
December 5, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30528868/varicella-vaccine-effectiveness-over-10-years-in-australia-moderate-protection-from-1-dose-program
#14
Helen E Quinn, Heather F Gidding, Helen S Marshall, Robert Booy, Elizabeth J Elliott, Peter Richmond, Nigel Crawford, Peter B McIntyre, Kristine K Macartney
OBJECTIVES: To examine the impact of Australia's single dose infant varicella vaccination program, we assessed single dose varicella vaccine effectiveness (VE) in preventing hospitalised disease using two methods. METHODS: Clinically confirmed varicella cases from the Paediatric Active Enhanced Disease Surveillance (PAEDS) sentinel network were age-matched to 20 controls obtained from the Australian Immunisation Register. Conditional logistic regression models were used to estimate VE and compared with estimates obtained using our second approach...
December 5, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30503843/interplay-of-personal-pet-and-environmental-colonization-in-households-affected-by-community-associated-methicillin-resistant-staphylococcus-aureus
#15
Patrick G Hogan, Ryan L Mork, Mary G Boyle, Carol E Muenks, John J Morelli, Ryley M Thompson, Melanie L Sullivan, Sarah J Gehlert, Jessica R Merlo, Matt G McKenzie, Juliane Bubeck Wardenburg, Andrey Rzhetsky, Carey-Ann D Burnham, Stephanie A Fritz
OBJECTIVE: We sought to determine the prevalence, molecular epidemiology, and factors associated with Staphylococcus aureus environmental surface and pet colonization in households of children with community-associated methicillin-resistant S. aureus (CA-MRSA) infection. METHODS: Between 2012 and 2015, 150 children with CA-MRSA infections and their household contacts and pets were enrolled in this cross-sectional study in metropolitan Saint Louis, MO. Cultures to detect S...
November 29, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30503842/whole-genome-sequencing-detects-inter-facility-transmission-of-carbapenem-resistant-klebsiella-pneumoniae
#16
Melanie D Spencer, Kathryn Winglee, Catherine Passaretti, Ashlee M Earl, Abigail L Manson, Holly P Mulder, Robert L Sautter, Anthony A Fodor
OBJECTIVES: To identify transmission patterns of Carbapenem-resistant Klebsiella pneumoniae infection during an outbreak at a large, tertiary care hospital and to detect whether the outbreak organisms spread to other facilities in the integrated healthcare network METHODS: We analyzed 71 K. pneumoniae whole genome sequences collected from clinical specimens before, during and after the outbreak and reviewed corresponding patient medical records. Sequence and patient data were used to model probable transmissions and assess factors associated with the outbreak...
November 29, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30476494/redefining-influenza-seasonality-at-a-global-scale-and-aligning-it-to-the-influenza-vaccine-manufacturing-cycle-a-descriptive-time-series-analysis
#17
David J Muscatello
OBJECTIVES: Annual seasonal influenza vaccine manufacturing cycles align with temperate country seasonality in each hemisphere, yet influenza seasonality is poorly defined for many countries. The study introduces a novel and universal approach to defining and classifying seasonality that can be used to classify any country's influenza vaccine cycle alignment. METHODS: Countries reporting to the World Health Organization's FluNet influenza virology database in 90% of weeks during 2011 through 2017 were included...
November 23, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30476493/next-generation-sequencing-of-the-balf-in-the-diagnosis-of-community-acquired-pneumonia-in-immunocompromised-patients
#18
LETTER
Tingting Pan, Ruoming Tan, Hongping Qu, Xing Weng, Zhaojun Liu, Meiling Li, Jialin Liu
No abstract text is available yet for this article.
November 23, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30476492/invasive-meningococcal-disease-as-a-cause-of-sudden-and-unexpected-death-in-a-teenager-the-public-health-importance-of-confirming-the-diagnosis
#19
LETTER
Helen Campbell, Ray Borrow, Chitra Arumugam, Mary Ramsay, Shamez Ladhani
No abstract text is available yet for this article.
November 23, 2018: Journal of Infection
https://www.readbyqxmd.com/read/30471300/wide-spectrum-of-referral-routes-for-acute-hepatitis-e-infections
#20
LETTER
Benedict Rogers, Becky Haywood, Joicy David, Ayushi Patel, Samreen Ijaz, Julian W Tang
No abstract text is available yet for this article.
November 21, 2018: Journal of Infection
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