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Journal of Infection

Jing-Wen Ai, Hao-Cheng Zhang, Peng Cui, Bin Xu, Yan Gao, Qi Cheng, Tao Li, Honglong Wu, Wen-Hong Zhang
We reported a cluster of meningitis cases where next-generation sequencing enabled comprehensive and rapid diagnosis of causative agents. Study attempted a novel application of next-generation sequencing through the dynamic and direct semi-quantitive surveillance of pathogen loads in cerebralspinal fluids, suggesting its potential in reflecting disease progression and therapeutic efficacy evaluation during clinical approach. NGS may perform as a promising tool for infectious disease course surveillance through its ability of revealing the direct connection between pathogen loads and variate disease states in the future...
November 13, 2017: Journal of Infection
Eva Hong, Anne-Sophie Barret, Aude Terrade, Mélanie Denizon, Denise Antona, Myriam Aouiti-Trabelsi, Ala-Eddine Deghmane, Isabelle Parent du Châtelet, Daniel Levy-Bruhl, Muhamed-Kheir Taha
Background Neisseria meningitidis group W (NmW) belonging to the clonal complex ST-11 (NmW/cc11) spread in Europe and in France in 2000 and declined thereafter. In France, invasive meningococcal disease (IMD) due to NmW increased again in 2012 and thereafter since 2015. Several sub-lineages of NmW/cc11 are circulating worldwide with successive epidemic waves. We aimed to describe recent epidemiological trends of NmW in France and to explore the microbiological and epidemiological characteristics associated with different NmW/cc11 sub-lineages...
November 10, 2017: Journal of Infection
Sudeep Karve, Kellie Ryan, Pascale Peeters, Elisa Baelen, Sonia Rojas-Farreras, Danielle Potter, Jesús Rodríguez-Baño
OBJECTIVES: RECOMMEND (NCT02364284; D4280R00005) assessed treatment patterns and outcomes associated with initial antibiotic therapy (IAT; antibiotics received <48 h post-initiation of antibiotic therapy) in healthcare-associated infections across five countries. METHODS: Data from medical records of hospitalized patients aged ≥18 years with healthcare-associated complicated urinary tract infections (cUTI) are presented. Univariate and multivariate logistic regression analyses identified potential risk factors associated with IAT failure...
November 8, 2017: Journal of Infection
C Samuelson, H Kaur, E I Kritsotakis, S D Goode, A Nield, D Partridge
OBJECTIVES: To assess impact of a topical decontamination regimen on rates of catheter-related bloodstream infections (CRBSI) in intensively-treated haematology patients. METHODS: A historically-controlled cohort study was used to evaluate the effect of applying chlorhexidine or Octenisan® body washes and nasal Prontoderm® ointment for 5 days around the time of Hickman line insertion on the incidence of CRBSI and infection-free catheter time. Lines inserted during a 24 month period prior to implementation of the decolonisation regimen were compared with those inserted during a 12 month period after the intervention was applied...
November 7, 2017: Journal of Infection
Yanpeng Li, Xilong Deng, Fengyu Hu, Jian Wang, Ying Liu, Huang Huang, Jinmin Ma, Jianhui Zhang, Fuchun Zhang, Chiyu Zhang
No abstract text is available yet for this article.
October 31, 2017: Journal of Infection
Thomas McGregor, Frances A Bu'Lock, Martin Wiselka, Julian W Tang
No abstract text is available yet for this article.
October 27, 2017: Journal of Infection
Malgorzata Mikulska, Diana Averbuch, Frederic Tissot, Catherine Cordonnier, Murat Akova, Thierry Calandra, Marcello Ceppi, Paolo Bruzzi, Claudio Viscoli
OBJECTIVES: Fluoroquinolone (FQ) prophylaxis was recommended in 2005 by European Conference on Infections in Leukemia (ECIL) for patients with prolonged neutropenia. In consideration of a worldwide increase in antibiotic resistance, the issue of FQ prophylaxis during neutropenia was re-evaluated. METHODS: Literature review of randomised controlled trials (RCT) and observational studies published in years 2006-2014 was performed. Their results were analysed in meta-analysis...
October 25, 2017: Journal of Infection
Isaac Rosado-Sánchez, I Herrero-Fernández, Laura Tarancon-Diez, Santiago Moreno, Jose Antonio Iribarren, David Dalmau, Francisco Vera-Méndez, M Leal, Y M Pacheco
BACKGROUND: Despite the fact that antiretroviral therapy (cART) suppresses HIV-viremia, an adequate CD4 T-cell recovery is not always achieved (immunodiscordant response to cART). IL17a-producing CD4 T-cells (Th17) constitutes an important subset involved in the preservation of mucosal surfaces integrity, which depletion has been associated with disease progression in HIV-infection. However, whether Th17 frequency at cART initiation is associated with a poor CD4 T-cell recovery has not been yet explored...
October 25, 2017: Journal of Infection
Guanghao Sun, Nguyen Vu Trung, Takemi Matsui, Koichiro Ishibashi, Tetsuo Kirimoto, Hiroki Furukawa, Le Thi Hoi, Nguyen Nguyen Huyen, Quynh Nguyen, Shigeto Abe, Yukiya Hakozaki, Nguyen Van Kinh
No abstract text is available yet for this article.
October 24, 2017: Journal of Infection
Stefano Malinverni, Anne-Françoise Gennotte, Monica Schuster, Stéphane De Wit, Pierre Mols, Agnès Libois
BACKGROUND: Non-occupational post-exposure prophylaxis (nPEP) is a recommended public health intervention after a sexual or percutaneous exposure to human immunodeficiency virus (HIV). METHODS: We conducted a prospective observational study recording consultations for nPEP at a reference HIV center in Brussels, Belgium from January 2011 to December 2015. We recorded attendance to follow-up, reported completion of nPEP and pharmacy records to measure adherence. Multivariate logistic regressions were performed to identify independent risk factors for adherence to nPEP and attendance to first follow-up visit at the STI clinic...
October 23, 2017: Journal of Infection
A M W Efsen, A Schultze, R F Miller, A Panteleev, A Skrahin, D N Podlekareva, J M Miro, E Girardi, H Furrer, M H Losso, J Toibaro, J A Caylà, A Mocroft, J D Lundgren, F A Post, O Kirk
OBJECTIVES: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce. METHODS: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART). RESULTS: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB...
October 20, 2017: Journal of Infection
Michael G Head, Rebecca J Brown, Stuart C Clarke
INTRODUCTION: Infectious disease remains a significant burden in the UK and the focus of significant amounts of research investment each year. The Research Investments in Global Health study has systematically assessed levels of funding for infection research, and here considers investment alongside UK burden of individual infectious diseases. METHODS: The study included awards to UK institutions between 1997 and 2013 that were related to infectious disease. Awards related to global health projects were excluded here...
October 20, 2017: Journal of Infection
Se Yoon Park, Taeeun Kim, Min-Chul Kim, Heungsup Sung, Mi-Na Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Jun Hee Woo, Yang Soo Kim, Yong Pil Chong
No abstract text is available yet for this article.
October 18, 2017: Journal of Infection
Shimin Gao, Yinfeng Kang, Siyao Li, Bin Xiang, Haili Ma, Runyu Yuan
No abstract text is available yet for this article.
October 14, 2017: Journal of Infection
E Roycroft, R F O'Toole, M M Fitzgibbon, L Montgomery, M O'Meara, P Downes, S Jackson, J O'Donnell, I F Laurenson, A M McLaughlin, J Keane, T R Rogers
OBJECTIVES: The primary objective of this work was to examine the acquisition and spread of multi-drug resistant (MDR) tuberculosis (TB) in Ireland. METHODS: All available Mycobacterium tuberculosis complex (MTBC) isolates (n = 42), from MDR-TB cases diagnosed in Ireland between 2001 and 2014, were analysed using phenotypic drug-susceptibility testing, Mycobacterial-Interspersed-Repetitive-Units Variable-Number Tandem-Repeat (MIRU-VNTR) genotyping, and whole-genome sequencing (WGS)...
October 12, 2017: Journal of Infection
Julia M Baker, Wladimir J Alonso
OBJECTIVES: This study aimed to examine the previously unknown long-term spatio-temporal patterns in diarrheal morbidity and mortality across age groups and geography in Brazil under the light of evolving socioeconomic factors and interventions. METHODS: Nationwide mortality (1979-2014) and hospitalization (1998-2014) data were obtained from the Brazilian Ministry of Health. Analyses of long-term secular trends and seasonality of diarrheal morbidity and mortality were performed in EPIPOI (www...
October 12, 2017: Journal of Infection
Abhay Deep Pandey, Saptamita Goswami, Shweta Shukla, Shaoli Das, Suman Ghosal, Manisha Pal, Bhaswati Bandyopadhyay, Vishnampettai Ramachandran, Nandita Basu, Vikas Sood, Priyanka Pandey, Jayprokas Chakrabarti, Sudhanshu Vrati, Arup Banerjee
The association of long non-coding RNAs (lncRNAs) with dengue disease progression is currently unknown. Therefore, the present study aimed to identify lncRNAs in different categories of dengue patients and evaluate their association with dengue disease progression. Herein, we examined the expression profiles of lncRNAs and protein-coding genes between other febrile illness (OFI) and different grade of dengue patients through high-throughput RNA sequencing. We identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as one of the differentially expressed lncRNAs (adjusted P ≤ 0...
October 12, 2017: Journal of Infection
Gajanan N Sapkal, Pragya D Yadav, Mahendra M Vegad, Rajlakshmi Viswanathan, Nivedita Gupta, Devendra T Mourya
No abstract text is available yet for this article.
October 5, 2017: Journal of Infection
Raquel Abad, Verónica Medina, Maria Del Carmen Fariñas, Luis Martínez-Martínez, Stefania Bambini, A Dari, Duccio Medini, Mariagrazia Pizza, Julio A Vázquez
The analysis of the potential impact of the meningococcal vaccines in asymptomatic carriers has become one of the key aspects in the evaluation of new vaccines and of their impact on disease control. An important step in this direction is provided by the analysis of the sequence variability and surface-exposure of the 4CMenB (Bexsero®) vaccine antigens, as well as the cross-reactivity of vaccine induced antibodies, in isolates from healthy carriers. The Spanish Reference Laboratory, in collaboration with the University Hospital Marqués de Valdecilla in Santander (Spain), carried out a meningococcal carrier survey between May 2010 and April 2012 (population aged 4 to 19 years)...
October 5, 2017: Journal of Infection
Kaliaperumal Kanagasabai, Vasna Joshua, Muthusamy Ravi, R Sabarinathan, B K Kirubakaran, V Ramachandran, Manoj V Murhekar
No abstract text is available yet for this article.
September 29, 2017: Journal of Infection
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