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Journal of Infection

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https://www.readbyqxmd.com/read/28322889/anti-hiv-antibody-and-drug-combinations-exhibit-synergistic-activity-against-drug-resistant-hiv-1-strains
#1
LETTER
Qianqian Qi, Qian Wang, Weizao Chen, Fei Yu, Lanying Du, Dimiter S Dimitrov, Lu Lu, Shibo Jiang
No abstract text is available yet for this article.
March 17, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28322887/staphylococcus-aureus-bacteremia-in-patients-with-rheumatoid-arthritis-data-from-the-prospective-instinct-cohort
#2
Insa Joost, Achim Kaasch, Christine Pausch, Gabriele Peyerl-Hoffmann, Christian Schneider, Reinhard E Voll, Harald Seifert, Winfried V Kern, Siegbert Rieg
OBJECTIVES: Patients with rheumatoid arthritis (RA) are considered to be at increased risk of severe infections. We here describe the clinical characteristics, course and outcome of RA patients with Staphylococcus aureus bacteremia (SAB). METHODS: We conducted a post hoc analysis of data from a German bi-centre prospective SAB cohort study (period 2006-2014). Patients were followed-up for one year. Primary and secondary outcomes were survival time and osteoarticular infection (OAI)...
March 17, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28322888/review-manuscript-pneumolysin-as-a-potential-therapeutic-target-in-severe-pneumococcal-disease
#3
REVIEW
Ronald Anderson, Charles Feldman
Acute pulmonary and cardiac injury remain significant causes of morbidity and mortality in those afflicted with severe pneumococcal disease, with the risk for early mortality often persisting several years beyond clinical recovery. Although remaining to be firmly established in the clinical setting, a considerable body of evidence, mostly derived from murine models of experimental infection, has implicated the pneumococcal, cholesterol-binding, pore-forming toxin, pneumolysin (Ply), in the pathogenesis of lung and myocardial dysfunction...
March 16, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28315721/current-outcomes-and-predictors-of-treatment-failure-in-patients-with-surgical-site-infection-after-elective-colorectal-surgery-a-multicentre-prospective-cohort-study
#4
Aina Gomila, Josep Ma Badia, Jordi Carratalà, Xavier Serra-Aracil, Evelyn Shaw, Vicens Diaz-Brito, Antoni Castro, Elena Espejo, Carmen Nicolás, Marta Piriz, Montserrat Brugués, Josefina Obradors, Ana Lérida, Jordi Cuquet, Enric Limón, Francesc Gudiol, Miquel Pujol
OBJECTIVE: To determine current outcomes and predictors of treatment failure among patients with surgical site infection (SSI) after colorectal surgery. METHODS: A multicentre observational prospective cohort study of adults undergoing elective colorectal surgery in 10 Spanish hospitals (2011-2014). Treatment failure was defined as persistence of signs/symptoms of SSI or death at 30 days post-surgery. RESULTS: Of 3,701 patients, 669 (18.1%) developed SSI; 336 (9...
March 15, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28279715/characteristics-and-changes-in-invasive-meningococcal-disease-epidemiology-in-france-2006-2015
#5
I Parent du Chatelet, A E Deghmane, D Antona, E Hong, L Fonteneau, M K Taha, D Lévy-Bruhl
OBJECTIVES: This work aimed to describe the epidemiology of invasive meningococcal disease (IMD) in France, 2006-2015, including group- and genotype-specific disease burden, incidence trends before and after introduction of meningococcal C conjugate vaccines (MCCV) in 2010, and factors influencing the case fatality rate. METHODS: Mandatory notification data on incidence and IMD case characteristics were used. Genotyping of invasive strains and whole genome sequencing were performed by the French National Reference Center...
March 7, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28267572/pneumolysin-mediates-heterotypic-aggregation-of-neutrophils-and-platelets-in%C3%A2-vitro
#6
Jan G Nel, Chrisna Durandt, Annette J Theron, Gregory R Tintinger, Roger Pool, Guy A Richards, Timothy J Mitchell, Charles Feldman, Ronald Anderson
OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the pneumococcal toxin, pneumolysin (Ply), activates production of platelet-activating factor (PAF) and thromboxane A2 (TxA2) by neutrophils, these bioactive lipids being potential mediators of neutrophil:platelet (NP) networking. METHODS: The effects of recombinant Ply (10-80 ng mL(-1)) on the production of PAF and TxA2 by isolated neutrophils were measured using ELISA procedures, and NP aggregation by flow cytometry...
March 4, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28282505/completeness-of-case-ascertainment-and-availability-of-environmental-data-in-legionnaires-disease-enhanced-surveillance-in-england-2012-2014
#7
LETTER
F Naik, K Chandler, Y Rehman, G Dabrera
No abstract text is available yet for this article.
March 2, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28263759/diagnostic-and-vaccine-strategies-to-prevent-infections-in-patients-with-inflammatory-bowel-disease
#8
REVIEW
Giovanni Mazzola, Fabio Salvatore Macaluso, Lucia Adamoli, Sara Renna, Antonio Cascio, Ambrogio Orlando
OBJECTIVES: The treatment of inflammatory bowel disease (IBD) has been revolutionized by the use of immunomodulatory agents. Although these potent drugs are effective in controlling disease activity, they also cause an increased risk of new infections or reactivation of latent infections. On these premises, we aimed to provide guidance on the definitions of immunocompromised patients, opportunistic infections and the risk factors associated with their occurrence in an IBD context, and to suggest the proper screening tests for infectious diseases and the vaccination schedules to perform before and/or during therapy with immunomodulators...
March 2, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28254419/human-papillomavirus-infection-and-cervical-lesions-in-hiv-infected-women-on-antiretroviral-treatment-in-thailand
#9
Tristan Delory, Nicole Ngo-Giang-Huong, Samreung Rangdaeng, Nantasak Chotivanich, Aram Limtrakul, Chaiwat Putiyanun, Pornnapa Suriyachai, Wanmanee Matanasarawut, Tapnarong Jarupanich, Prateung Liampongsabuddhi, Isabelle Heard, Gonzague Jourdain, Marc Lallemant, Sophie Le Coeur
OBJECTIVES: To estimate the prevalence and factors associated with Human Papillomavirus (HPV) infection, HPV genotypes and cytological/histological high-grade (HSIL+/CIN2+) lesions. METHODS: We conducted a cross-sectional study within a prospective cohort of HIV-infected women on combination antiretroviral therapy (cART). Cervical specimens were collected for cytology and HPV genotyping (Papillocheck(®)). Any women with High-Risk-HPV (HR-HPV), and/or potentially HR-HPV (pHR-HPV) and/or ASC-US or higher (ASC-US+) lesions were referred for colposcopy...
February 28, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28245429/corrigendum-to-the-role-of-primary-infection-of-schwann-cells-in-the-aetiology-of-infective-inflammatory-neuropathies-j%C3%A2-infect-73-2016-402-418
#10
J W Neal, P Gasque
No abstract text is available yet for this article.
February 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28237625/selective-sensitization-of-human-neutrophils-to-lukgh-mediated-cytotoxicity-by-staphylococcus-aureus-and-il-8
#11
Philipp Janesch, Harald Rouha, Susanne Weber, Stefan Malafa, Karin Gross, Barbara Maierhofer, Adriana Badarau, Zehra C Visram, Lukas Stulik, Eszter Nagy
OBJECTIVES: Staphylococcus aureus produces up to five bi-component leukocidins - LukSF-PV, gamma-hemolysins AB and CB, LukGH (LukAB) and LukED - to evade innate immunity by lysing phagocytic cells. Species specificity of these leukocidins limits the relevance of animal models, therefore we assessed their individual contribution using human neutrophils. METHODS: Human polymorphonuclear leukocytes (PMNs) were activated with stimuli relevant during bacterial infections and sensitivity to recombinant leukocidins was measured in cell-viability assays...
February 22, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28237624/three-year-evaluation-of-xpert-mtb-rif-in-a-low-prevalence-tuberculosis-setting-a-scottish-perspective
#12
Benjamin J Parcell, Anna Jarchow-MacDonald, Amie-Louise Seagar, Ian Laurenson, Gordon J Prescott, Michael Lockhart
OBJECTIVES: Xpert MTB/RIF (Cepheid) is a rapid molecular assay shown to be sensitive and specific for pulmonary tuberculosis (TB) diagnosis in highly endemic countries. We evaluated its diagnostic performance in a low TB prevalence setting, examined rifampicin resistance detection and quantitative capabilities predicting graded auramine microscopy and time to positivity (TTP) of culture. METHODS: Xpert MTB/RIF was used to test respiratory samples over a 3 year period...
February 22, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28237623/effect-of-underlying-immune-compromise-on-the-manifestations-and-outcomes-of-group-a-streptococcal-bacteremia
#13
Kathleen A Linder, Leen Alkhouli, Mayur Ramesh, George A Alangaden, Carol A Kauffman, Marisa H Miceli
BACKGROUND: Group A streptococcal bloodstream infection is the most common presentation of invasive group A streptococcal disease. We sought to determine the impact of immunosuppression on severity of disease and clinical outcomes. METHODS: This retrospective review of 148 patients with at least one positive blood culture for Streptococcus pyogenes from 1/2003 to 3/2013 compared immunocompromised patients with those with no immunocompromise in regards to development of severe complications and mortality...
February 22, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28189714/the-impact-of-co-infection-of-influenza-a-virus-on-the-severity-of-middle-east-respiratory-syndrome-coronavirus
#14
LETTER
Sarah H Alfaraj, Jaffar A Al-Tawfiq, Nojoom A Alzahrani, Talal A Altwaijri, Ziad A Memish
No abstract text is available yet for this article.
February 9, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28189713/the-painting-of-st-roch-in-the-picture-gallery-of-bari-15th-century-an-ancient-representation-of-dracunculiasis
#15
LETTER
Raffaele Gaeta, Fabrizio Bruschi, Valentina Giuffra
No abstract text is available yet for this article.
February 9, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28189712/interleukin-1-receptor-antagonist-a-biomarker-of-response-to-anti-tb-treatment-in-hiv-tb-co-infected-patients
#16
Janin Nouhin, Polidy Pean, Yoann Madec, Mathieu F Chevalier, Celine Didier, Laurence Borand, François-Xavier Blanc, Daniel Scott-Algara, Didier Laureillard, Laurence Weiss
OBJECTIVES: Despite the high frequency of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in human immunodeficiency virus (HIV)/TB co-infected patients, no diagnostic test is available. Here, we investigated whether monocyte/macrophage activation markers can predict TB-IRIS occurrence and if they are modulated by anti-TB treatment. METHODS: Frozen plasma was obtained from 127 HIV/TB co-infected adults naïve for antiretroviral therapy, enrolled in the CAMELIA trial, 36 of whom developed TB-IRIS...
February 9, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28189711/model-informed-risk-assessment-for-zika-virus-outbreaks-in-the-asia-pacific-regions
#17
Yue Teng, Dehua Bi, Guigang Xie, Yuan Jin, Yong Huang, Baihan Lin, Xiaoping An, Yigang Tong, Dan Feng
Recently, Zika virus (ZIKV) has been recognized as a significant threat to global public health. The disease was present in large parts of the Americas, the Caribbean, and also the western Pacific area with southern Asia during 2015 and 2016. However, little is known about the factors affecting the transmission of ZIKV. We used Gradient Boosted Regression Tree models to investigate the effects of various potential explanatory variables on the spread of ZIKV, and used current with historical information from a range of sources to assess the risks of future ZIKV outbreaks...
February 9, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28188817/a-sensitive-and-specific-rapid-diagnostic-test-for-severe-fever-with-thrombocytopenia-syndrome-virus
#18
LETTER
Xiao-Ai Zhang, Sabrina Li, Jesus Ching, Zhen-Dong Yang, Ning Cui, Pan-He Zhang, Jian-Gong Hu, Wei Liu
No abstract text is available yet for this article.
February 8, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28167123/low-incidence-of-acute-hepatitis-c-virus-infection-among-southern-spanish-hiv-infected-individuals
#19
LETTER
María Mancebo, Juan Macías, Nicolás Merchante, Luis M Real, Fernando Lozano, Lara Domínguez, María J Álvarez-Ossorio, Fernando Saussol, Pilar Rincón, Juan A Pineda, Karin Neukam
No abstract text is available yet for this article.
February 3, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28143755/rabies-transmission-following-organ-transplantation-in-china
#20
LETTER
Cheng Gong, Xiaomei Li, Ming Luo, Zhen Zhang, Qinghai Wang, Qing Wang, Lu Zhang, Fang Huang, Tiegang Zhang, Tao Zhou, Fan Yang, Qing Tang, Fan Jiang, Li Lu, Jiang Wu
No abstract text is available yet for this article.
January 29, 2017: Journal of Infection
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