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Journal of Infection

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https://www.readbyqxmd.com/read/29782899/an-even-better-use-of-laboratory-resources-for-diagnosing-dengue-in-the-uk
#1
LETTER
Seb Cotton, Kate Templeton
No abstract text is available yet for this article.
May 18, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29778631/staphylococcus-aureus-bloodstream-infection-in-patients-with-ventricular-assist-devices-management-and-outcome-in-a-prospective-bicenter-cohort
#2
Insa Joost, Wolfgang Bothe, Christine Pausch, Achim Kaasch, Berit Lange, Gabriele Peyerl-Hoffmann, Greta Flüh, Matthias Müller, Christian Schneider, Harald Seifert, Winfried V Kern, Friedhelm Beyersdorf, Siegbert Rieg
OBJECTIVES: Ventricular assist devices (VAD) are increasingly implanted in patients with terminal heart failure. Here we describe the clinical course, management and outcome of VAD patients with S. aureus bloodstream infection (SAB). METHODS: We conducted a post hoc analysis of data from 1073 patients who had been prospectively enrolled in two consecutive SAB bicenter cohort studies. Patients with VAD in situ at the onset of SAB were identified. Follow-up of patients was at least 90 days...
May 17, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29778630/bcg-vaccination-protects-against-infection-with-mycobacterium-tuberculosis-ascertained-by-tuberculin-skin-testing
#3
Pelzer Pt, Mutayoba B, Cobelens Fgj
OBJECTIVES: There is conflicting evidence as to whether Bacillus Calmette-Guérin (BCG) vaccination offers protection against Mycobacterium tuberculosis infection ascertained by a positive tuberculin skin test (TST). We investigated the association between BCG vaccination status and TST results in a set of surveys at increasing TST cut-off values to take cross-reactions to BCG vaccination into account. METHODS: Secondary analysis of data from three consecutive tuberculin surveys done among schoolchildren in Tanzania between 1990 and 2002...
May 17, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29778629/what-is-the-criterion-of-high-pentraxin-3-ptx-3-cutoff-in-patients-with-sepsis
#4
LETTER
Xianshi Zhou, Ye Ye, Guanghua Tang
No abstract text is available yet for this article.
May 17, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29777718/malnutrition-is-associated-with-diminished-baseline-and-mycobacterial-antigen-stimulated-chemokine-responses-in-latent-tuberculosis-infection
#5
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Nathella Pavan Kumar, Chandrakumar Dolla, Subash Babu
OBJECTIVES: Previous studies have demonstrated a diminution in the baseline and mycobacterial antigen - specific cytokines in low body mass index (LBMI) individuals with latent tuberculosis infection (LTBI). We hypothesized that LBMI might be also associated with alteration in the baseline and antigen - stimulated levels of chemokines in LTBI. METHODS: To test this hypothesis, we examined baseline, TB- antigen and mitogen stimulated levels of chemokines in these individuals and compared them with those with LTBI and normal BMI (NBMI)...
May 16, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29758242/diagnostic-accuracy-of-nucleic-acid-amplification-based-assays-for-tuberculous-meningitis-a-meta-analysis
#6
Renu Gupta, Puneet Talwar, Pumanshi Talwar, Sarbjeet Khurana, Suman Kushwaha, Nupur Jalan, Rajeev Thakur
BACKGROUND: Numerous in-house and commercial nucleic acid amplification tests (NAAT) have been evaluated using variable reference standards for diagnosis of TBM but their diagnostic potential is still not very clear. METHODS: We conducted a meta-analysis to assess the diagnostic accuracy of different NAAT based assays for diagnosing TBM against 43 data sets of confirmed TBM (n=1066) and 61 data sets of suspected TBM (n=3721) as two reference standards. The summary estimate of the sensitivity and the specificity were obtained using the bivariate model...
May 11, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29752963/ses-proteins-as-possible-targets-for-vaccine-development-against-staphylococcus-epidermidis-infections
#7
Dorien Hofmans, Laleh Khodaparast, Ladan Khodaparast, Els Vanstreels, Mohammad Shahrooei, Johan Van Eldere, Lieve Van Mellaert
OBJECTIVES: The opportunistic pathogen Staphylococcus epidermidis is progressively involved in device-related infections. Since these infections involve biofilm formation, antibiotics are not effective. Conversely, a vaccine can be advantageous to prevent these infections. In view of vaccine development, predicted surface proteins were evaluated on their potential as a vaccine target. METHODS: Immunoglobulins directed against S. epidermidis surface proteins SesB, M, O, Q and R, were used to firstly affirm their surface location...
May 9, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746955/micafungin-versus-posaconazole-prophylaxis-in-acute-leukemia-or-myelodysplastic-syndrome-a-randomized-study
#8
David J Epstein, Susan K Seo, Yao-Ting Huang, Jay H Park, Virginia M Klimek, Ellin Berman, Martin S Tallman, Mark G Frattini, Genovefa A Papanicolaou
OBJECTIVES: To compare the effectiveness and tolerability of micafungin versus posaconazole during chemotherapy-induced neutropenia in acute leukemia (AL) and myelodysplastic syndrome (MDS). METHODS: Patients with AL or MDS undergoing chemotherapy were randomized to open-label micafungin 100 mg intravenously daily or posaconazole suspension 400 mg orally twice daily until neutrophil recovery, up to 28 days. Patients were followed for 12 weeks. The primary endpoint was prophylaxis failure (premature discontinuation due to infection, intolerance, adverse event, or death)...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746954/combined-ifn-%C3%AE-and-tnf-%C3%AE-release-assay-for-differentiating-active-tuberculosis-from-latent-tuberculosis-infection
#9
Ji Yeun Kim, Joung Ha Park, Min Chul Kim, Hye Hee Cha, Na-Young Jeon, Seong Yeon Park, Min-Jae Kim, Yong-Phil Chong, Sang Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung Han Kim
OBJECTIVES: The IFN-γ-release assay (IGRA) cannot differentiate active tuberculosis (TB) from latent TB infection (LTBI). We hypothesized that the TNF-α-release assay (TARA) combined with IGRA might discriminate active TB from not active TB without LTBI. METHODS: Adult patients with suspected TB, and with unrelated diseases such as herpes zoster as controls, were enrolled in an intermediate TB-burden country. Patients with confirmed or probable TB were regarded as active TB, and patients with not active TB were further classified as those having not active TB with and without LTBI based on IGRA results...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746953/reversion-of-quantiferon-tb-gold-in-tube-test-in-individuals-with-and-without-prophylactic-treatment-for-latent-tuberculosis-infection-a-systematic-review-and-meta-analysis
#10
Haoran Zhang, Henan Xin, Xiangwei Li, Hengjing Li, Mufei Li, Boxuan Feng, Lei Gao
OBJECTIVES: Reversion of tuberculosis (TB) infection testing has been suggested to be associated with prophylactic treatment efficacy. However, evidences based on randomized controlled study were sparse. METHODS: Studies on serial QuantiFERON-TB Gold In-Tube (QFT) test, among individuals with and without prophylactic treatment were identified in the databases of PubMed, MEDLINE and EMBASE up to 28 February 2018. The reversion rates were quantitatively summarized by means of meta-analysis using the random-effect model...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746952/metagenomics-facilitated-complete-genome-sequencing-of-adenovirus-untyped-by-real-time-pcr
#11
LETTER
Xiaohui Zou, Yanyan Fan, Wang Zhang, Binghuai Lu, Yingmei Liu, Bin Cao
No abstract text is available yet for this article.
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746951/oligonucleotide-aptamers-promising-and-powerful-diagnostic-and-therapeutic-tools-for-infectious-diseases
#12
REVIEW
Qin Pan, Fengling Luo, Min Liu, Xiao-Lian Zhang
The entire human population is at risk of infectious diseases worldwide. Thus far, the diagnosis and treatment of human infectious diseases at the molecular and nanoscale levels have been extremely challenging tasks because of the lack of effective probes to identify and recognize biomarkers of pathogens. Oligonucleotide aptamers are a class of small nucleic acid ligands that are composed of single-stranded DNA (ssDNA) or RNA and act as affinity probes or molecular recognition elements for a variety of targets...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746950/candida-periprosthetic-joint-infection-a-rare-and-difficult-to-treat-infection
#13
Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Oscar Murillo, Helem Vilchez, Luisa Sorli, Laura Guío Carrión, José Mª Barbero, Julián Palomino-Nicás, Alberto Bahamonde, Alfredo Jover-Sáenz, Natividad Benito, Rosa Escudero, Marta Fernandez- Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S Corona, Benito Almirante, Javier Ariza, Carles Pigrau
BACKGROUND: Candida periprosthetic joint infection (CPJI) is a rare, difficult-to-treat disease. The purpose of this study was to evaluate the clinical characteristics and outcomes of CPJI treated with various surgical and antifungal strategies. METHODS: We conducted a multicenter retrospective study of all CPJI diagnosed between 2003 and 2015 in 16 Spanish hospitals. RESULTS: Forty-three patients included: median age, 75 years, and median Charlson Comorbidity Index score, 4...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746949/variation-in-coagulation-and-fibrinolysis-genes-evaluated-for-their-contribution-to-cerebrovascular-complications-in-adults-with-bacterial-meningitis-in-the-netherlands
#14
A T Kloek, H N Khan, M Valls Seron, A Jongejan, A H Zwinderman, F Baas, A van der Ende, D van de Beek, B Ferwerda, M C Brouwer
OBJECTIVE: To study whether genetic variation in coagulation and fibrinolysis genes contributes to cerebrovascular complications in bacterial meningitis. METHODS: We performed a nationwide prospective genetic association study in adult community-acquired bacterial meningitis patients. The exons and flanking regions of 16 candidate genes involved in coagulation and fibrinolysis pathways were sequenced. We analyzed whether genetic variation in these genes resulted in a higher risk of cerebrovascular complications, unfavorable outcome and differences in thrombocyte count on admission...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746948/long-term-morbidity-and-mortality-following-bloodstream-infection-a-systematic-literature-review
#15
REVIEW
John F McNamara, Elda Righi, Hugh Wright, Gunter F Hartel, Patrick N A Harris, David L Paterson
OBJECTIVES: Bloodstream infection results in significant short-term morbidity and mortality. No literature review has studied the long-term outcome following a bloodstream infection. This PROSPERO registered systematic review evaluated studies, which measured the association of a bloodstream infection with long-term morbidity and mortality. METHODS: Databases were systematically searched for studies of adult patients reporting morbidity and/or mortality one year or more following a bloodstream infection in comparison to a matched cohort without a bloodstream infection...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746947/seroepidemiology-of-coxsackievirus-a10-infection-in-infants-and-children-a-prospective-cohort-study-in-jiangsu-china
#16
LETTER
Ying Fua, Shi-Yang Sun, Qun-Ying Mao, Lian-Lian Bian, Xing Wu, Feng-Cai Zhu, Chun-Lai Jiang, Fan Gao, Zheng-Lun Liang
No abstract text is available yet for this article.
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746946/pneumonic-and-non-pneumonic-exacerbations-in-bronchiectasis-clinical-and-microbiological-differences
#17
Eva Polverino, Edmundo Rosales-Mayor, Mariana Benegas, Rosario Menendez, Victoria Alcaraz-Serrano, Emilio Ansotegui, Beatriz Montull, Rosa María Girón, Carolina Cisneros, Montserrat Vendrell, Gerard Muñoz, María Angeles Marcos, Marcelo Sanchez, Antoni Torres
OBJECTIVES: Despite the clinical relevance of exacerbations in bronchiectasis (BE), little is known about the microbiology and outcomes of pneumonic (CAP) vs. non-pneumonic (NOCAP) exacerbations. METHODS: This study compares clinical and microbiological characteristics of CAP vs. NOCAP in adults with BE. We performed a multicenter prospective observational study of consecutive cases of NOCAP and CAP from four Spanish hospitals (2011-2015). RESULTS: We recruited 144 patients, 47 of them CAP (33%) cases...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746945/activation-of-coagulation-and-endothelium-with-concurrent-impairment-of-anticoagulant-mechanisms-in-patients-with-typhoid-fever
#18
Hanna K de Jong, Chris M Parry, Thomas W van der Vaart, Liesbeth M Kager, Stannie J van den Ende, Rapeephan R Maude, Lalith Wijedoru, Aniruddha Ghose, Mohammed U Hasan, Mohammed A Hossain, Arjan M Dondorp, Steve Baker, M Abul Faiz, Joost C M Meijers, W Joost Wiersinga
OBJECTIVES: Typhoid fever caused by Salmonella Typhi remains a major burden worldwide. Gastrointestinal bleeding can be seen in up to 10 percent of patients and may be fatal. The coagulopathy, which may be the driver of this severe complication in patients with typhoid fever, however is ill defined. The aim of this study was to evaluate the activation of coagulation, anticoagulation, and fibrinolysis in patients with acute typhoid fever. METHODS: . Parameters of coagulation and fibrinolysis were measured in 28 hospitalized patients with culture-confirmed or PCR-confirmed typhoid fever and compared to 38 age- and sex-matched healthy volunteers...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746944/increased-risk-of-autoimmune-diseases-in-dengue-patients-a-population-based-cohort-study
#19
Hao-Ming Li, Ying-Kai Huang, Yuan-Chih Su, Chia-Hung Kao
OBJECTIVE: To investigate the risk of autoimmune diseases in dengue patients. METHODS: We conducted a population-based cohort study by the Taiwan National Health Insurance Research Database, including a total of 12506 newly diagnosed dengue patients and 112554 control subjects between 2000 and 2010, matched by gender, age, income, urbanization, and comorbidities. Both cohorts were followed for a 3-year period to examine the incidence of autoimmune diseases. A Cox proportional hazards regression analysis was applied to calculate the risk of autoimmune diseases between both groups...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746943/immune-response-eliciting-exposure-to-campylobacter-vastly-exceeds-the-incidence-of-clinically-overt-campylobacteriosis-but-is-associated-with-similar-risk-factors-a-nationwide-serosurvey-in-the-netherlands
#20
Susana Monge, Peter Teunis, Ingrid Friesema, Eelco Franz, Wim Ang, Wilfrid van Pelt, Lapo Mughini-Gras
BACKGROUND: We aimed to estimate population-level exposure to Campylobacter and associated risk factors, using three approaches for serological data analysis. METHODS: Nationwide, population-based serosurvey in the Netherlands (Feb2006-Jun2007). Anti-Campylobacter IgG, IgM and IgA were measured using ELISA, and analysed via: a) seroincidence estimation, using reference values of antibody peak levels and decay rates over-time after Campylobacter exposure; b) two normal distributions of true positives/negatives fitted to the IgG distribution to derive seroprevalence and individual probability of being positive/negative; and c) IgG levels...
May 7, 2018: Journal of Infection
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