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Journal of Infection

Marc Rondy, Nathalie El Omeiri, Mark G Thompson, Alain Levêque, Alain Moren, Sheena Sullivan
OBJECTIVES: Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized influenza is lacking. We conducted a meta-analysis of studies reporting IVE against laboratory-confirmed hospitalized influenza among adults. METHODS: We searched Pubmed (January 2009 to November 2016) for studies that used test-negative design (TND) to enrol patients hospitalized with influenza-associated conditions. Two independent authors selected relevant articles. We calculated pooled IVE against any and (sub)type specific influenza among all adults, and stratified by age group (18-64 and 65 years and above) using random-effects models...
September 18, 2017: Journal of Infection
Kristin K Cox, Bruce Alexander, Daniel J Livorsi, Brett H Heintz
Objectives Trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin are frequently prescribed to treat cellulitis. The primary objective was to determine if weight-based dosing of these antibiotics is associated with better outcomes in cellulitis. The secondary objective was to assess variables associated with clinical failure among hospitalized patients with cellulitis with or without cutaneous abscess. Methods This multi-center retrospective cohort study was conducted from January 1, 2010 to September 4, 2014...
September 15, 2017: Journal of Infection
Reena Shah, Hilda Nabiswa, Nancy Okinda, Gunturu Revathi, Mark Hawken, Mark Nelson
No abstract text is available yet for this article.
September 14, 2017: Journal of Infection
Núria Prim, Miquel Turbau, Alba Rivera, Judith Rodríguez-Navarro, Pere Coll, Beatriz Mirelis
Objectives The objectives were to determine the prevalence of colistin resistance in clinical isolates of Enterobacteriaceae, and to gain knowledge on the epidemiological and clinical features of the patients. Methods All colistin-resistant Enterobacteriaceae consecutively isolated from clinical samples in our institution from 2012 to 2015, were included in this cross-sectional study. Intrinsic-resistant species with were excluded. Minimum inhibitory concentration was performed by gradient diffusion. Detection of plasmid-encoded colistin resistance genes mcr-1 and mcr-2 was performed by amplification...
September 14, 2017: Journal of Infection
Minas P Economides, Leomar Y Ballester, Vinodh A Kumar, Ying Jiang, Jeffrey Tarrand, Victor Prieto, Harrys A Torres, Dimitrios P Kontoyiannis
BACKGROUND: Historically considered to have very poor outcome, there is paucity of recent data regarding invasive mold infections (IMIs) of the central nervous system (CNS) in patients with hematologic cancer (HC) or stem cell transplantation (SCT). METHODS: We reviewed the records of HC patients and/or SCT recipients who were diagnosed with CNS IMIs (EORTC/MSG criteria) at MD Anderson Cancer Center (1/1/2000-6/31/2016). Risk factors for survival at day (d) 42 post diagnosis were assessed...
September 14, 2017: Journal of Infection
James Veater, Nicholas Wong, Florence Y Lai, Iain Stephenson, Martin Wiselka, Julian W Tang
No abstract text is available yet for this article.
September 14, 2017: Journal of Infection
G Tapia, J F Højen, M Ökvist, R Olesen, S Leth, S K Nissen, D J VanBelzen, U O'Doherty, A Mørk, K Krogsgaard, O S Søgaard, L Østergaard, M Tolstrup, G Pantaleo, M A Sommerfelt
OBJECTIVES: The REDUC clinical study Part B investigated Vacc-4x/rhuGM-CSF therapeutic vaccination prior to HIV latency reversal using romidepsin. The main finding was a statistically significant reduction from baseline in viral reservoir measurements. Here we evaluated HIV-specific functional T-cell responses following Vacc-4x/rhuGM-CSF immunotherapy in relation to virological outcomes on the HIV reservoir. METHODS: This study, conducted in Aarhus, Denmark, enrolled participants (n=20) with CD4>500 cells/mm(3) on cART...
September 13, 2017: Journal of Infection
Xuemeng Ji, Ping-Ping Yao, Le-Yi Zhang, Yi Li, Fang Xu, Ling-Ling Mei, Shui-Rong Zhu, Yan-Jun Zhang, Han-Ping Zhu, Stijn van der Veen
OBJECTIVES: The bacterial pathogen Neisseria meningitidis is able to escape the currently available capsule-based vaccines by undergoing capsule switching. In this study, we investigated whether capsule switching has occurred in a recently emerged sequence type (ST) 7 serogroup X isolate in China, for which currently no vaccine is available. METHODS: To identify capsule switching breakpoints, the capsule locus and flanking regions of the ST-7 serogroup X isolate and three endemic ST-7 serogroup A isolates were sequenced and compared...
September 12, 2017: Journal of Infection
Wen Su, Kit Ling Cheng, Daniel K W Chu, Jie Zhou, Xiaoxiao Mao, Zhifeng Zhong, Yingchao Song, Malik Peiris, Jie Wu, Hui-Ling Yen
No abstract text is available yet for this article.
September 7, 2017: Journal of Infection
Binghui Wang, Yuebo Liang, Yunnan Lu, Li Zhang, Yaping Li, Yuzhu Song, Chengfeng Qin, Zhongxin Luo, Zhiqing Xia, Weihong Qin, Xueshan Xia
No abstract text is available yet for this article.
September 7, 2017: Journal of Infection
Reena Shah, Hilda Nabiswa, Nancy Okinda, Gunturu Revathi, Mark Hawken, Mark Nelson
No abstract text is available yet for this article.
September 4, 2017: Journal of Infection
Chun-Yuan Lee, Chung-Hao Huang, Po-Liang Lu, Wen-Chien Ko, Yen-Hsu Chen, Po-Ren Hsueh
OBJECTIVES: Rifampin was initially approved for the treatment of tuberculosis. Because of its low toxicity, broad-spectrum activity, and good bioavailability, rifampin is now commonly administered as combination antimicrobial therapy for the treatment of various infections caused by organisms other than mycobacteria. This review summarizes the most recent clinical studies on the use of rifampin combinations for treating four common non-mycobacterial infections: acute bacterial meningitis, infective endocarditis and bacteraemia, pneumonia, and biofilm-related infections...
September 1, 2017: Journal of Infection
Angela Domínguez, Núria Soldevila, Joan Artur Caylà, Manuel García-Cenoz, Glòria Ferrús, Maria Rosa Sala-Farré, Josep Álvarez, Mònica Carol, Irene Barrabeig, Neus Camps, Lorena Coronas, Carmen Muñoz-Almagro, Pere Godoy
OBJECTIVES: We assessed the value of the clinical symptoms included in the case definition of pertussis in household contacts of laboratory-confirmed cases. METHODS: A prospective epidemiological study was made in two Spanish regions. Household contacts were identified for each confirmed case reported during 2012 and 2013. Two clinical samples were taken to determine the presence or absence of Bordetella pertussis by culture or real-time PCR. Clinical variables, age and vaccination status were recorded...
September 1, 2017: Journal of Infection
George Bedu-Addo, Marie Alicke, Justice K Boakye-Appiah, Inusah Abdul-Jalil, Markus van der Giet, Matthias B Schulze, Frank P Mockenhaupt, Ina Danquah
OBJECTIVES: Malaria in pregnancy (MiP) contributes to fetal undernutrition and adverse birth outcomes, and may constitute a developmental origin of metabolic diseases in the offspring. In a Ghanaian birth cohort, we examined the relationships between MiP-exposure and metabolic traits in adolescence. METHODS: MiP at delivery was assessed in 155 mother-child pairs. Among the now teenaged children (mean age, 14.8 years; 53% male), we measured fasting plasma glucose (FPG), body mass index (BMI), and systolic and diastolic blood pressure (BP)...
August 26, 2017: Journal of Infection
Chien-Chang Lee, Chia-Hung Yo, Meng-Tse Gabriel Lee, Kuang-Chau Tsai, Shih-Hao Lee, Yueh-Sheng Chen, Wan-Chien Lee, Tzu-Chun Hsu, Sie-Hue Lee, Shy-Shin Chang
OBJECTIVES: To determine the trend of incidence and outcome of sepsis based on a nationwide administrative database. METHODS: We analyzed the incidence and mortality of both emergency department treated and hospital treated sepsis from 2002 through 2012 using the entire health insurance claims data of Taiwan. The national health insurance covers 99% of residents in Taiwan. Sepsis patients were identified using a set of validated ICD-9CM codes conforming to the sepsis-3 definition...
August 26, 2017: Journal of Infection
Carmen Cabellos, Ivan Pelegrín, Eva Benavent, Francesc Gudiol, Fe Tubau, Dolores Garcia-Somoza, Ricard Verdaguer, Javier Ariza, Pedro Fernandez-Viladrich
BACKGROUND: Invasive meningococcal disease is a severe infection. The appropriate duration of antibiotic therapy is not well established. METHODS: Two hundred and sixty-three consecutive patients with invasive meningococcal disease treated with 4 days' antibiotic therapy were compared with 264 consecutive patients treated previously at the same center with 7 days' antibiotic therapy. A Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR) study was also performed...
August 25, 2017: Journal of Infection
Jessica Barrett, Clare E Warrell, Liana Macpherson, Julie Watson, Patricia Lowe, Margaret Armstrong, Christopher J M Whitty
INTRODUCTION: Determining the cause of eosinophilia in patients returning from the tropics continues to present a diagnostic challenge. The history, symptoms and degree of eosinophilia are often poor predictors of eventual diagnosis, but helminths are an important cause. The current British Infection Association recommendations use travel history to guide investigation of eosinophilia. However the global burden of helminth disease and travel patterns have changed over the last 3 decades and guidelines based on previous epidemiology need to be reviewed in the light of current data...
August 24, 2017: Journal of Infection
P Bruijning-Verhagen, M D Nipshagen, H de Graaf, M J M Bonten
Rotavirus (RV) is highly endemic inside and outside hospital-settings. Immunocompromised children and adults are at risk of complicated rotavirus gastroenteritis (RVGE), but general rotavirus disease severity in this group remains poorly described and rotavirus testing is not routinely performed beyond infancy. We assessed rotavirus disease among immunocompromised hospitalized patients. METHODS: Rotavirus infections at a Dutch tertiary-care centre were identified from 5-year laboratory records...
August 13, 2017: Journal of Infection
Yu Pang, Jie Lu, Fengmin Huo, Yifeng Ma, Liping Zhao, Yunxu Li, Qian Liang, Naihui Chu, Mengqiu Gao, Hairong Huang
OBJECTIVES: The objective of this study was to explore the prevalence and primary clinical outcomes of extensively drug-resistant tuberculosis plus addition resistance to all drug tested (XDR-TB-Plus) between 2011 and 2015 in Beijing Chest Hospital. METHODS: We retrospectively reviewed the drug susceptibility testing (DST) results of clinical Mycobacterium tuberculosis (MTB) strains from TB patients seeking health care in the National Clinical Center for Tuberculosis, between 2011 and 2015...
August 11, 2017: Journal of Infection
Rosarito Coronel Teixeira, Mabel Rodríguez, Nilda Jiménez de Romero, Marcel Bruins, Roscio Gómez, Jan Bart Yntema, Gilberto Chaparro Abente, Jan Willem Gerritsen, Wim Wiegerinck, Domingo Pérez Bejerano, Cecile Magis-Escurra
INTRODUCTION: Tuberculosis (TB) is the leading cause of death due to an infectious disease worldwide. Especially in low-income countries, new diagnostic techniques that are accessible, inexpensive and easy-to-use, are needed to shorten transmission time and initiate treatment earlier. OBJECTIVE: We conducted a study with a handheld, point-of-care electronic nose (eNose) device to diagnose TB through exhaled breath. SETTING: This study includes a total of 110 patients and visitors of an expert centre of respiratory diseases in Asunción, Paraguay...
August 10, 2017: Journal of Infection
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