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Hypertension

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https://www.readbyqxmd.com/read/27895194/systematic-characterization-and-prediction-of-human-hypertension-genes
#1
Yan-Hui Li, Gai-Gai Zhang, Nanping Wang
Hypertension is a major cardiovascular risk factor and accounts for a large part of cardiovascular mortality. In this work, we analyzed the properties of hypertension genes and found that when compared with genes not yet known to be involved in hypertension regulation, known hypertension genes display distinguishing features: (1) hypertension genes tend to be located at network center; (2) hypertension genes tend to interact with each other; and (3) hypertension genes tend to enrich in certain biological processes and show certain phenotypes...
November 28, 2016: Hypertension
https://www.readbyqxmd.com/read/27895193/organum-vasculosum-of-the-lamina-terminalis-detects-nacl-to-elevate-sympathetic-nerve-activity-and-blood-pressure
#2
Brian J Kinsman, Sarah S Simmonds, Kirsteen N Browning, Sean D Stocker
High-salt diet elevates NaCl concentrations in the cerebrospinal fluid to increase sympathetic nerve activity (SNA) in salt-sensitive hypertension. The organum vasculosum of the lamina terminalis (OVLT) resides along the rostral wall of the third ventricle, lacks a complete blood-brain barrier, and plays a pivotal role in body fluid homeostasis. Therefore, the present study used a multifaceted approach to examine whether OVLT neurons of Sprague-Dawley rats are intrinsically sensitive to changes in extracellular NaCl concentrations and mediate the sympathoexcitatory responses to central NaCl loading...
November 28, 2016: Hypertension
https://www.readbyqxmd.com/read/27895192/development-of-left-ventricular-hypertrophy-in-treated-hypertensive-outpatients-the-campania-salute-network
#3
Raffaele Izzo, Maria-Angela Losi, Eugenio Stabile, Mai Tone Lönnebakken, Grazia Canciello, Giovanni Esposito, Emanuele Barbato, Nicola De Luca, Bruno Trimarco, Giovanni de Simone
: There is little information on left ventricular (LV) hypertrophy (LVH) development during antihypertensive treatment. We evaluate incident LVH in a treated hypertensive cohort, the Campania Salute Network registry. We analyzed prospectively 4290 hypertensives (aged 50.3±11.1 years, 40% women) with at least 1-year follow-up, without LVH at baseline. Incident LVH was defined as the first detection of echocardiographic LV mass index ≥47 in women or ≥50 g/m(2.7) in men. During a median 48-month follow-up, 915 patients (21...
November 28, 2016: Hypertension
https://www.readbyqxmd.com/read/27895191/putative-mechanism-of-salt-dependent-neurogenic-hypertension-cell-autonomous-activation-of-organum-vasculosum-laminae-terminalis-neurons-by-hypernatremia
#4
EDITORIAL
https://www.readbyqxmd.com/read/27895190/caveolin-1-deletion-prevents-hypertensive-vascular-remodeling-induced-by-angiotensin-ii
#5
Steven J Forrester, Katherine J Elliott, Tatsuo Kawai, Takashi Obama, Michael J Boyer, Kyle J Preston, Zhen Yan, Satoru Eguchi, Victor Rizzo
It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by angiotensin II (AngII). We have tested our hypothesis that caveolin-1 (Cav1), a major structural protein of vascular caveolae, plays a critical role in the development of vascular remodeling by AngII via regulation of epidermal growth factor receptor and vascular endothelial adhesion molecule-1. Cav1(-/-) and control Cav(+/+) mice were infused with AngII for 2 weeks to induce vascular remodeling and hypertension...
November 28, 2016: Hypertension
https://www.readbyqxmd.com/read/27872236/preclinical-and-early-clinical-profile-of-a-highly-selective-and-potent-oral-inhibitor-of-aldosterone-synthase-cyp11b2
#6
Katrijn Bogman, Dietmar Schwab, Marie-Laure Delporte, Giuseppe Palermo, Kurt Amrein, Susanne Mohr, Maria Cristina De Vera Mudry, Morris J Brown, Philippe Ferber
Primary hyperaldosteronism is a common cause of resistant hypertension. Aldosterone is produced in the adrenal by aldosterone synthase (AS, encoded by the gene CYP11B2). AS shares 93% homology to 11β-hydroxylase (encoded by the gene CYP11B1), responsible for cortisol production. This homology has hitherto impeded the development of a drug, which selectively suppresses aldosterone but not cortisol production, as a new treatment for primary hyperaldosteronism. We now report the development of RO6836191 as a potent (Ki 13 nmol/L) competitive inhibitor of AS, with in vitro selectivity >100-fold over 11β-hydroxylase...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27872235/specific-aldosterone-synthase-inhibition-a-potential-improvement-over-mineralocorticoid-receptor-antagonism
#7
EDITORIAL
Markus P Schneider, Karl F Hilgers
No abstract text is available yet for this article.
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27872234/downregulation-of-endothelial-transient-receptor-potential-vanilloid-type-4-channel-and-small-conductance-of-ca2-activated-k-channels-underpins-impaired-endothelium-dependent-hyperpolarization-in-hypertension
#8
Takunori Seki, Kenichi Goto, Kanako Kiyohara, Yasuo Kansui, Noboru Murakami, Yoshie Haga, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono
Endothelium-dependent hyperpolarization (EDH)-mediated responses are impaired in hypertension, but the underlying mechanisms have not yet been determined. The activation of small- and intermediate-conductance of Ca(2+)-activated K(+) channels (SKCa and IKCa) underpins EDH-mediated responses. It was recently reported that Ca(2+) influx through endothelial transient receptor potential vanilloid type 4 channel (TRPV4) is a prerequisite for the activation of SKCa/IKCa in endothelial cells in specific beds. Here, we attempted to determine whether the impairment of EDH in hypertension is attributable to the dysfunction of TRPV4 and S/IKCa, using isolated superior mesenteric arteries of 20-week-old stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched Wistar-Kyoto (WKY) rats...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27872233/effects-of-percutaneous-transluminal-renal-angioplasty-on-office-and-home-blood-pressure-and-home-blood-pressure-variability-in-hypertensive-patients-with-renal-artery-stenosis
#9
Yoshio Iwashima, Tetsuya Fukuda, Hiroshi Kusunoki, Shin-Ichiro Hayashi, Masatsugu Kishida, Fumiki Yoshihara, Satoko Nakamura, Kei Kamide, Takeshi Horio, Yuhei Kawano
This study included 126 hypertensive patients with renal artery stenosis (mean age, 63 years; 22.2% fibromuscular dysplasia [FMD]) and investigated the effects of percutaneous transluminal renal angioplasty on office and home blood pressure (BP), and BP variability estimates derived from home BP, both at baseline and up to 12 months after angioplasty. Home BP was measured for 7 consecutive days, and the threshold defining uncontrolled home BP was ≥135/85 mm Hg. In both the FMD and atherosclerotic stenosis (ARAS) groups, office and home BP decreased significantly after angioplasty (all P<0...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27872232/therapeutic-potential-of-progranulin-in-hyperhomocysteinemia-induced-cardiorenal-dysfunction
#10
Yi Fu, Yu Sun, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Zeyu Su, Kaili Liang, Wei Tang, Fan Yi
Hyperhomocysteinemia (hHcys) is an important independent risk factor for the development of cardiovascular disease and end-stage renal disease. Although multiple approaches lowering the levels of homocysteine have been used in experimental studies and clinical trials, there is no effective therapy available to fully prevent homocysteine-induced injury. Therefore, identifying key molecules in the pathogenic pathways may provide clues to develop new therapeutic strategies for the treatment of hHcys-associated injury beyond lowering the plasma homocysteine levels...
November 21, 2016: Hypertension
https://www.readbyqxmd.com/read/27849568/sprint-blood-pressure-sprinting-back-to-smirk-s-basal-blood-pressure
#11
EDITORIAL
Gianfranco Parati, Juan Eugenio Ochoa, Grzegorz Bilo, Alberto Zanchetti
No abstract text is available yet for this article.
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849567/building-on-a-legacy-of-hypertension-research-charting-our-future-together
#12
REVIEW
George A Mensah, Zorina S Galis, Lawrence J Fine, Melissa E Garcia, Daniel F Levy, Gary H Gibbons
No abstract text is available yet for this article.
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849566/effects-of-sacubitril-valsartan-lcz696-on-natriuresis-diuresis-blood-pressures-and-nt-probnp-in-salt-sensitive-hypertension
#13
Tzung-Dau Wang, Ru-San Tan, Hae-Young Lee, Sang-Hyun Ihm, Moo-Yong Rhee, Brian Tomlinson, Parasar Pal, Fan Yang, Elizabeth Hirschhorn, Margaret F Prescott, Markus Hinder, Thomas H Langenickel
: Salt-sensitive hypertension (SSH) is characterized by impaired sodium excretion and subnormal vasodilatory response to salt loading. Sacubitril/valsartan (LCZ696) was hypothesized to increase natriuresis and diuresis and result in superior blood pressure control compared with valsartan in Asian patients with SSH. In this randomized, double-blind, crossover study, 72 patients with SSH received sacubitril/valsartan 400 mg and valsartan 320 mg once daily for 4 weeks each. SSH was diagnosed if the mean arterial pressure increased by ≥10% when patients switched from low (50 mmol/d) to high (320 mmol/d) sodium diet...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849565/association-between-long-term-blood-pressure-variability-and-10-year-progression-in-arterial-stiffness-the-multiethnic-study-of-atherosclerosis
#14
Yacob G Tedla, Yuichiro Yano, Mercedes Carnethon, Philip Greenland
Experimental studies conducted on animal and human endothelium suggested that higher systolic blood pressure (SBP) variability reduces bioavailability of nitric oxide and increases vascular smooth muscle cell proliferation. These vascular wall changes could stiffen the arterial wall. Using data from the Multiethnic Study of Atherosclerosis, we investigated the association between long-term SBP variability and 10-year percent change in arterial stiffness among 1122 individuals (mean age 57 years, 46% males at baseline) who were not taking antihypertensive medications...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849564/progression-of-carotid-arterial-stiffness-with-treatment-of-hypertension-over-10-years-the-multi-ethnic-study-of-atherosclerosis
#15
Adam D Gepner, Yacob Tedla, Laura A Colangelo, Matthew C Tattersall, Claudia E Korcarz, Joel D Kaufman, Kiang Liu, Gregory L Burke, Steven Shea, Philip Greenland, James H Stein
Associations with antihypertensive medication classes and progression of arterial stiffness have not been studied in a prospective multiethnic cohort. All participants had hypertension at baseline, defined as blood pressure ≥140/90 mm Hg or use of antihypertensive medications. Medication use and blood pressure were assessed at 5 time points. Young's elastic modulus and distensibility coefficient of the right common carotid artery were obtained by ultrasound at baseline and after a mean (SD) follow-up period of 9...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849563/effect-of-intensive-versus-standard-clinic-based-hypertension-management-on-ambulatory-blood-pressure-results-from-the-sprint-systolic-blood-pressure-intervention-trial-ambulatory-blood-pressure-study
#16
Paul E Drawz, Nicholas M Pajewski, Jeffrey T Bates, Natalie A Bello, William C Cushman, Jamie P Dwyer, Lawrence J Fine, David C Goff, William E Haley, Marie Krousel-Wood, Andrew McWilliams, Dena E Rifkin, Yelena Slinin, Addison Taylor, Raymond Townsend, Barry Wall, Jackson T Wright, Mahboob Rahman
: The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP) is unknown. The goal of the SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory BP ancillary study was to evaluate the effect of intensive versus standard clinic-based BP targets on ambulatory BP. Ambulatory BP was obtained within 3 weeks of the 27-month study visit in 897 SPRINT participants. Intensive treatment resulted in lower clinic systolic BP (mean difference between groups=16...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27840330/low-molecular-weight-heparin-improves-endothelial-function-in-pregnant-women-at-high-risk-of-preeclampsia
#17
Kelsey McLaughlin, Dora Baczyk, Audrey Potts, Michelle Hladunewich, John D Parker, John C P Kingdom
Low molecular weight heparin (LMWH) has been investigated for the prevention of severe preeclampsia, although the mechanisms of action are unknown. The objective of this study was to investigate the cardiovascular effects of LMWH in pregnant women at high risk of preeclampsia. Pregnant women at high risk of preeclampsia (n=25) and low-risk pregnant controls (n=20) at 22 to 26 weeks' gestation underwent baseline cardiovascular assessments. High-risk women were then randomized to LMWH or saline placebo (30 mg IV bolus and 1 mg/kg subcutaneous dose)...
November 13, 2016: Hypertension
https://www.readbyqxmd.com/read/27821619/increased-aortic-calcification-is-associated-with-arterial-stiffness-progression-in-multiethnic-middle-aged-men
#18
Jingchuan Guo, Akira Fujiyoshi, Bradley Willcox, Jina Choo, Abhishek Vishnu, Takashi Hisamatsu, Vasudha Ahuja, Naoyuki Takashima, Emma Barinas-Mitchell, Aya Kadota, Rhobert W Evans, Katsuyuki Miura, Daniel Edmundowicz, Kamal Masaki, Chol Shin, Lewis H Kuller, Hirotsugu Ueshima, Akira Sekikawa
Arterial stiffness is established as an independent predictor of cardiovascular morbidity and mortality. The objective was to prospectively evaluate association of aortic calcification burden with progression of arterial stiffness in population-based samples of healthy middle-aged men from ERA JUMP cohort (Electron-Beam Computed Tomography and Risk Factor Assessment in Japanese and US Men in the Post-World War II Birth Cohort). Men (n=635) aged 40 to 49 years (207 white American, 45 black American, 142 Japanese American, and 241 Japanese in Japan) were examined at baseline and 4 to 7 years later...
November 7, 2016: Hypertension
https://www.readbyqxmd.com/read/27821618/diurnal-blood-pressure-rhythmicity-in-relation-to-environmental-and-genetic-cues-in-untreated-referred-patients
#19
Chang-Sheng Sheng, Yi-Bang Cheng, Fang-Fei Wei, Wen-Yi Yang, Qian-Hui Guo, Fei-Ka Li, Qi-Fang Huang, Lutgarde Thijs, Jan A Staessen, Ji-Guang Wang, Yan Li
No previous study has addressed the relative contributions of environmental and genetic cues to the diurnal blood pressure rhythmicity. From 24-hour ambulatory recordings of systolic blood pressure obtained in untreated patients (51% women; mean age, 51 years), we computed the night-to-day ratio in 897 and morning surge in 637. Environmental cues included season, mean daily outdoor temperature, atmospheric pressure, humidity and weekday, and the genetic cues 14 single nucleotide polymorphisms in 10 clock genes...
November 7, 2016: Hypertension
https://www.readbyqxmd.com/read/27821617/increased-notch3-activity-mediates-pathological-changes-in-structure-of-cerebral-arteries
#20
Celine Baron-Menguy, Valérie Domenga-Denier, Lamia Ghezali, Frank M Faraci, Anne Joutel
CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established TgNotch3(R169C) mouse model develops characteristic features of the human disease, with deposition of NOTCH3 and other proteins, including TIMP3 (tissue inhibitor of metalloproteinase 3), on brain vessels, as well as reduced maximal dilation, and attenuated myogenic tone of cerebral arteries, but without elevated blood pressure...
November 7, 2016: Hypertension
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