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Hypertension

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https://www.readbyqxmd.com/read/28716993/low-soluble-fms-like-tyrosine-kinase-1-endoglin-and-endothelin-1-levels-in-women-with-confirmed-or-suspected-preeclampsia-using-proton-pump-inhibitors
#1
Langeza Saleh, Raaho Samantar, Ingrid M Garrelds, Anton H van den Meiracker, Willy Visser, A H Jan Danser
Patients with preeclampsia display elevated placenta-derived sFlt-1 (soluble Fms-like tyrosine kinase-1) and endoglin levels and decreased placental growth factor levels. Proton pump inhibitors (PPIs) decrease trophoblast sFlt-1 and endoglin secretion in vitro. PPIs are used during pregnancy to combat reflux disease. Here, we investigated whether PPIs affect sFlt-1 in women with confirmed/suspected preeclampsia, making use of a prospective cohort study involving 430 women. Of these women, 40 took PPIs (6 esomeprazole, 32 omeprazole, and 2 pantoprazole) for 8 to 45 (median 29) days before sFlt-1 measurement...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716992/blood-pressure-trajectories-and-the-risk-of-intracerebral-hemorrhage-and-cerebral-infarction-a-prospective-study
#2
Weijuan Li, Cheng Jin, Anand Vaidya, Yuntao Wu, Kathryn Rexrode, Xiaoming Zheng, Mahmut E Gurol, Chaoran Ma, Shouling Wu, Xiang Gao
The association between long-term blood pressure (BP) patterns in community-dwelling adults and risk of intracerebral hemorrhage and cerebral infarction is not well characterized. This prospective study included 79 385 participants, free of stroke, myocardial infarction, and cancer in or before 2010 (baseline). Systolic BP trajectories were identified using latent mixture modeling with data from 2006, 2008, and 2010. Incident cases of intracerebral hemorrhage and cerebral infarction occurred during 2010 to 2014, confirmed by review of medical records, by 3 physicians...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716991/expanding-clinical-phenotype-of-fibromuscular-dysplasia
#3
EDITORIAL
Jeffrey W Olin
No abstract text is available yet for this article.
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716990/proof-of-principle-for-a-novel-class-of-antihypertensives-that-target-the-oxidative-activation-of-protein-kinase-g-i%C3%AE
#4
Joseph R Burgoyne, Oleksandra Prysyazhna, Daniel A Richards, Philip Eaton
Arterial hypertension continues to be a major health burden. Development of new antihypertensive drugs that engage vasodilatory mechanisms not harnessed by available therapies offer therapeutic potential. Oxidants induce an interprotein disulfide in protein kinase G Iα (PKG Iα) at C42, which is associated with its targeting and activation, resulting in vasodilation and blood pressure lowering. Consequently, we developed an assay and screened for electrophilic drugs that activate PKG Iα by selectively targeting C42, as such compounds have potential as novel antihypertensives with a mechanism of action that differs from current therapies...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716989/high-prevalence-of-multiple-arterial-bed-lesions-in-patients-with-fibromuscular-dysplasia-the-arcadia-registry-assessment-of-renal-and-cervical-artery-dysplasia
#5
Pierre-François Plouin, Jean-Philippe Baguet, Frédéric Thony, Olivier Ormezzano, Arshid Azarine, François Silhol, Catherine Oppenheim, Béatrice Bouhanick, Louis Boyer, Alexandre Persu, Frank Hammer, Philippe Gosse, Claire Mounier-Vehier, Claire Le Hello, Xavier Jeunemaitre, Michel Azizi, Laurence Amar, Gilles Chatellier, Elie Mousseaux, Emmanuel Touzé
Fibromuscular dysplasia (FMD) commonly affects the renal and cervical arteries but has been described to affect other vascular beds as well. The prevalence of and clinical characteristics associated with multisite FMD (string-of-beds or focal stenoses affecting at least 2 vascular beds) are not known. In the prospective ARCADIA registry (Assessment of Renal and Cervical Artery Dysplasia), symptomatic patients with renal artery (RA) FMD underwent tomographic- or magnetic resonance-angiography from the aortic arch to the intracranial arteries and those with cervical FMD from the diaphragm to the pelvis...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716988/blood-pressure-lowering-and-safety-improvements-with-liver-angiotensinogen-inhibition-in-models-of-hypertension-and-kidney-injury
#6
Adam E Mullick, Steve T Yeh, Mark J Graham, Jeffery A Engelhardt, Thazha P Prakash, Rosanne M Crooke
Uncontrolled hypertension is an important contributor to cardiovascular disease. Despite the armamentarium of antihypertensive treatments, there remains a need for novel agents effective in individuals who cannot reach acceptable blood pressure levels. Inhibitors targeting the renin-angiotensin-aldosterone system (RAAS) are widely used but may not optimally inhibit RAAS and demonstrate an acceptable safety profile. Experiments were conducted to characterize a series of AGT (angiotensinogen) antisense oligonucleotides (ASOs) and compare their efficacy and tolerability to traditional RAAS blockade...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716987/control-of-pathological-cardiac-hypertrophy-by-transcriptional-corepressor-irf2bp2-interferon-regulatory-factor-2-binding-protein-2
#7
Jing Fang, Tianyu Li, Xuehai Zhu, Ke-Qiong Deng, Yan-Xiao Ji, Chun Fang, Xiao-Jing Zhang, Jun-Hong Guo, Peng Zhang, Hongliang Li, Xiang Wei
The transcription factor nuclear factor of activated T-cells 1 (NFAT1), with the aid of transcriptional coactivators, has been recognized for its necessity and sufficiency to drive pathological cardiac hypertrophy. However, how the transcriptional activity of NFAT1 in terms of cardiac hypertrophy is controlled at the transcriptional level has not been well defined. Herein, we showed that a cardiac-enriched protein IRF2BP2 (interferon regulatory factor-2 binding protein 2) was further upregulated in both human and mouse hypertrophied myocardium and negatively regulated cardiomyocyte hypertrophic response in vitro...
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28716986/development-of-protein-kinase-g-i%C3%AE-dimerizing-antihypertensive-drugs-are-we-standing-at-the-shore-of-the-rubicon
#8
EDITORIAL
Paula K Bautista-Niño, Anton J M Roks, A H Jan Danser
No abstract text is available yet for this article.
July 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28696224/increased-perfusion-pressure-drives-renal-t-cell-infiltration-in-the-dahl-salt-sensitive-rat
#9
Louise C Evans, Galina Petrova, Theresa Kurth, John D Bukowy, David L Mattson, Allen W Cowley
Renal T-cell infiltration is a key component of salt-sensitive hypertension in Dahl salt-sensitive (SS) rats. Here, we use an electronic servo-control technique to determine the contribution of renal perfusion pressure to T-cell infiltration in the SS rat kidney. An aortic balloon occluder placed around the aorta between the renal arteries was used to maintain perfusion pressure to the left kidney at control levels, ≈128 mm Hg, during 7 days of salt-induced hypertension, whereas the right kidney was exposed to increased renal perfusion pressure that averaged 157±4 mm Hg by day 7 of high-salt diet...
July 10, 2017: Hypertension
https://www.readbyqxmd.com/read/28696223/white-coat-effect-is-uncommon-in-patients-with-refractory-hypertension
#10
Mohammed Siddiqui, Eric K Judd, Suzanne Oparil, David A Calhoun
Refractory hypertension is a recently described phenotype of antihypertensive treatment failure defined as uncontrolled blood pressure (BP) despite the use of ≥5 different antihypertensive agents, including chlorthalidone and spironolactone. Recent studies indicate that refractory hypertension is uncommon, with a prevalence of ≈5% to 10% of patients referred to a hypertension specialty clinic for uncontrolled hypertension. The prevalence of white coat effect, that is, uncontrolled automated office BP ≥135/85 mm Hg and controlled out-of-office BP <135/85 mm Hg, by awake ambulatory BP monitor in hypertensive patients overall is ≈30% to 40%...
July 10, 2017: Hypertension
https://www.readbyqxmd.com/read/28674039/aortic-arch-pulse-wave-velocity-assessed-by-magnetic-resonance-imaging-as-a-predictor-of-incident-cardiovascular-events-the-mesa-multi-ethnic-study-of-atherosclerosis
#11
Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang-Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R Chugh, Alban Redheuil, Chia-Ying Liu, Colin O Wu, W Gregory Hundley, David A Bluemke, Eliseo Guallar, Joao A C Lima
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (multi-ethnic study of atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in relation to arch PWV adjusted for age, sex, race, and CVD risk factors...
July 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28674038/genetic-interference-with-endothelial-peroxisome-proliferator-activated-receptor-%C3%AE-augments-effects-of-angiotensin-ii-while-impairing-responses-to-angiotensin-1-7
#12
T Michael De Silva, Chunyan Hu, Dale A Kinzenbaw, Mary L Modrick, Curt D Sigmund, Frank M Faraci
Pharmacological activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial PPAR-γ protects against angiotensin II-induced endothelial dysfunction. Here, we explored that concept further examining whether effects were sex dependent along with underlying mechanisms. We studied mice expressing a human dominant-negative mutation in PPAR-γ driven by the endothelial-specific vascular cadherin promoter (E-V290M), using nontransgenic littermates as controls...
July 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28674036/influence-of-child-and-adult-elevated-blood-pressure-on-adult-arterial-stiffness-the-cardiovascular-risk-in-young-finns-study
#13
Heikki Aatola, Teemu Koivistoinen, Heikki Tuominen, Markus Juonala, Terho Lehtimäki, Jorma S A Viikari, Olli T Raitakari, Mika Kähönen, Nina Hutri-Kähönen
Elevated blood pressure (BP) in childhood has been associated with increased adult arterial stiffness, the independent predictor of cardiovascular and all-cause mortality. The favorable BP change from childhood to adulthood and the risk of high adult arterial stiffness has not been reported. We examined the effect of child and adult BP on pulse wave velocity (PWV) assessed in adulthood among 1540 white adults followed-up for 27 years since baseline (1980, aged 6-18 years). Childhood elevated BP was defined according to the tables from the National High Blood Pressure Education Program...
July 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28674035/early-life-detection-of-hypertension-risks-implications-for-clinical-practice-and-research
#14
EDITORIAL
Daniel T Lackland
No abstract text is available yet for this article.
July 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28652474/rapid-screening-of-primary-aldosteronism-by-a-novel-chemiluminescent-immunoassay
#15
Ryo Morimoto, Yoshikiyo Ono, Yuta Tezuka, Masataka Kudo, Sachiko Yamamoto, Toshiaki Arai, Celso E Gomez-Sanchez, Hironobu Sasano, Sadayoshi Ito, Fumitoshi Satoh
Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents and detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in 10 minutes by a fully automated assay using antibody-immobilized magnetic particles with quick aggregation and dispersion...
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652472/proteomic-biostatistic-integrated-approach-for-finding-the-underlying-molecular-determinants-of-hypertension-in-human-plasma
#16
Prathibha R Gajjala, Vera Jankowski, Georg Heinze, Grzegorz Bilo, Alberto Zanchetti, Heidi Noels, Elisa Liehn, Paul Perco, Anna Schulz, Christian Delles, Felix Kork, Erik Biessen, Krzysztof Narkiewicz, Kalina Kawecka-Jaszcz, Juergen Floege, Davide Soranna, Walter Zidek, Joachim Jankowski
Despite advancements in lowering blood pressure, the best approach to lower it remains controversial because of the lack of information on the molecular basis of hypertension. We, therefore, performed plasma proteomics of plasma from patients with hypertension to identify molecular determinants detectable in these subjects but not in controls and vice versa. Plasma samples from hypertensive subjects (cases; n=118) and controls (n=85) from the InGenious HyperCare cohort were used for this study and performed mass spectrometric analysis...
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652470/contribution-of-increased-angiotensin-ii-sensitivity-to-microvascular-dysfunction-in-women-with-a-history-of-preeclampsia
#17
EDITORIAL
Charlotte W Usselman, Nina S Stachenfeld
No abstract text is available yet for this article.
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652468/is-plasma-proteomics-able-to-provide-alternative-paths-to-better-understand-hypertension
#18
EDITORIAL
Àngel Argilés, Mariano Rodriguez, Alberto Ortiz
No abstract text is available yet for this article.
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652467/systolic-blood-pressure-and-biochemical-assessment-of-adherence-a-cross-sectional-analysis-in-the-emergency-department
#19
Candace D McNaughton, Nancy J Brown, Russell L Rothman, Dandan Liu, Edmond K Kabagambe, Phillip D Levy, Wesley H Self, Alan B Storrow, Sean P Collins, Christianne L Roumie
Elevated blood pressure (BP) is common in the emergency department (ED), but the relationship between antihypertensive medication adherence and BP in the ED is unclear. This cross-sectional study tested the hypothesis that higher antihypertensive adherence is associated with lower systolic BP (SBP) in the ED among adults with hypertension who sought ED care at an academic hospital from July 2012 to April 2013. Biochemical assessment of antihypertensive adherence was performed using a mass spectrometry blood assay, and the primary outcome was average ED SBP...
June 26, 2017: Hypertension
https://www.readbyqxmd.com/read/28652466/guidelines-under-fire-again
#20
EDITORIAL
John Chalmers
No abstract text is available yet for this article.
June 26, 2017: Hypertension
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