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Hypertension

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https://www.readbyqxmd.com/read/29987110/renal-outcomes-in-medically-and-surgically-treated-primary-aldosteronism
#1
Gregory L Hundemer, Gary C Curhan, Nicholas Yozamp, Molin Wang, Anand Vaidya
Lifelong therapy with mineralocorticoid receptor antagonists (MRAs) or surgical adrenalectomy are the recommended treatments for primary aldosteronism (PA). Whether these treatments mitigate the risk for kidney disease remains unknown. We performed a retrospective cohort study of patients with PA treated with MRAs (N=400) or surgical adrenalectomy (N=120) and age- and estimated glomerular filtration rate-matched patients with essential hypertension (N=15 474) to determine risk for chronic kidney disease and longitudinal estimated glomerular filtration rate decline...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987109/dpp-dipeptidyl-peptidase-4-inhibition-potentiates-the-vasoconstrictor-response-to-npy-neuropeptide-y-in-humans-during-renin-angiotensin-aldosterone-system-inhibition
#2
Scott A Hubers, Jessica R Wilson, Chang Yu, Hui Nian, Eric Grouzmann, Philippe Eugster, Cyndya A Shibao, Frederic T Billings, Scott Jafarian Kerman, Nancy J Brown
DPP (dipeptidyl peptidase)-4 inhibitors are antidiabetic drugs that may increase heart failure in high-risk patients. NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by DPP4 to NPY (3-36) in vitro. NPY (3-36) decreases release of norepinephrine via the Y2 receptor. We tested the hypothesis that DPP4 inhibition would potentiate the vasoconstrictor effect of NPY. Eighteen nonsmokers (12 healthy controls and 6 with type 2 diabetes mellitus) participated in 1 of 2 randomized, double-blind, placebo-controlled crossover studies...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987108/at-2-r-angiotensin-at2-receptor-agonist-compound-21-prevents-abdominal-aortic-aneurysm-progression-in-the-rat
#3
Christoph Lange, Manuela Sommerfeld, Pawel Namsolleck, Ulrich Kintscher, Thomas Unger, Elena Kaschina
The effects of the selective AT2 R (angiotensin AT2 receptor) agonist, Compound 21 (C21), on abdominal aortic aneurysm formation were investigated in normotensive Wistar rats. Abdominal aortic aneurysm was induced by perfusion of isolated aortic segments with elastase. Treatment with C21 (0.03 mg/kg daily) was started after operation and continued for 14 days. Sham-operated animals and vehicle-treated animals after aneurysm induction served as controls. Aortic diameter, aortic wall distensibility, and pulse propagation velocity were measured via ultrasound...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987107/renin-angiotensin-system-in-aortic-aneurysm-still-adding-puzzle-stones-to-an-anything-but-complete-picture
#4
EDITORIAL
U Muscha Steckelings, Michael Bader
No abstract text is available yet for this article.
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987106/uric-acid-and-hypertension-because-of-arterial-stiffness
#5
EDITORIAL
Masanari Kuwabara, Mehmet Kanbay, Ichiro Hisatome
No abstract text is available yet for this article.
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987105/objective-but-not-subjective-short-sleep-duration-is-associated-with-hypertension-in-obstructive-sleep-apnea
#6
Rong Ren, Naima Covassin, Linghui Yang, Yun Li, Ye Zhang, Junying Zhou, Lu Tan, Taomei Li, Xiao Li, Yanyan Wang, Jihui Zhang, Yun-Kwok Wing, Weimin Li, Virend K Somers, Xiangdong Tang
Extremes of sleep duration and obstructive sleep apnea (OSA) are both associated with hypertension. We aimed to explore whether sleep duration modifies the relationship between OSA and prevalent hypertension, using both objective and subjective measures of total sleep duration. A total of 7107 OSA patients and 1118 primary snorers were included in the study. Hypertension was defined based either on direct blood pressure measures or on diagnosis by a physician. Objective sleep duration was derived by polysomnography and subjective sleep duration was self-reported...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987104/role-of-renin-angiotensin-aldosterone-system-activation-in-promoting-cardiovascular-fibrosis-and-stiffness
#7
REVIEW
Guanghong Jia, Annayya R Aroor, Michael A Hill, James R Sowers
No abstract text is available yet for this article.
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987103/involvement-of-arterial-stiffness-and-inflammation-in-hyperuricemia-related-development-of-hypertension
#8
Hirofumi Tomiyama, Kazuki Shiina, Charalambos Vlachopoulos, Yoichi Iwasaki, Chisa Matsumoto, Kazutaka Kimura, Masatsune Fujii, Taishiro Chikamori, Akira Yamashina
This study analyzed repeated measurement data to clarify the longitudinal associations between hyperuricemia and the risk factors for the development of hypertension (ie, increased arterial stiffness, renal dysfunction, and inflammation), and then examined whether these risk factors show longitudinal associations with the development of hypertension. In 3274 Japanese men without hypertension, the brachial-ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, and serum uric acid and CRP (C-reactive protein) levels were measured annually over an 8-year period...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987102/ship-ahoy-study-of-high-blood-pressure-in-pediatrics-adult-hypertension-onset-in-youth-rationale-design-and-methods
#9
Brenda Mendizábal, Elaine M Urbina, Richard Becker, Stephen R Daniels, Bonita E Falkner, Gilad Hamdani, Coral D Hanevold, Stephen R Hooper, Julie R Ingelfinger, Marc Lande, Lisa J Martin, Kevin Meyers, Mark Mitsnefes, Bernard Rosner, Joshua A Samuels, Joseph T Flynn
Although hypertension is identifiable in children and adolescents, there are many knowledge gaps on how to best define and manage high blood pressure in the young. SHIP-AHOY (Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth) is being conducted to address these knowledge gaps. Five hundred adolescents will be recruited and will undergo ambulatory blood pressure monitoring, echocardiographic, vascular, and cognitive assessments, as well as epigenetic studies to identify mechanisms that underlie the development of hypertensive target organ damage...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987101/epithelial-sodium-channel-in-aldosterone-induced-endothelium-stiffness-and-aortic-dysfunction
#10
Guanghong Jia, Javad Habibi, Annayya R Aroor, Michael A Hill, Yan Yang, Adam Whaley-Connell, Frederic Jaisser, James R Sowers
Enhanced activation of the endothelial mineralocorticoid receptor contributes to the development of arterial stiffness, which is an independent predictor of cardiovascular disease. Previously, we showed that enhanced endothelium mineralocorticoid receptor signaling in female mice prompts expression and translocation of the α-subunit of the epithelial sodium channel to the endothelial cell (EC) surface (EnNaC) inducing vascular fibrosis and stiffness. Further, amiloride, an epithelial sodium channel antagonist, inhibits vascular fibrosis, remodeling, and stiffness induced by feeding a Western diet high in saturated fat and refined carbohydrates...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29987100/computed-tomography-and-adrenal-venous-sampling-in-the-diagnosis-of-unilateral-primary-aldosteronism
#11
Tracy A Williams, Jacopo Burrello, Leonardo A Sechi, Carlos E Fardella, Joanna Matrozova, Christian Adolf, René Baudrand, Stella Bernardi, Felix Beuschlein, Cristiana Catena, Michalis Doumas, Francesco Fallo, Gilberta Giacchetti, Daniel A Heinrich, Gaëlle Saint-Hilary, Pieter M Jansen, Andrzej Januszewicz, Tomaz Kocjan, Tetsuo Nishikawa, Marcus Quinkler, Fumitoshi Satoh, Hironobu Umakoshi, Jiří Widimský, Stefanie Hahner, Stella Douma, Michael Stowasser, Paolo Mulatero, Martin Reincke
Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and is usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical and biochemical postsurgical outcomes of patients with unilateral primary aldosteronism diagnosed by CT or AVS and identify predictors of surgical outcomes. Patient data were obtained from 18 internationally distributed centers and retrospectively analyzed for clinical and biochemical outcomes of adrenalectomy of patients with surgical management based on CT (n=235 patients, diagnosed from 1994-2016) or AVS (526 patients, diagnosed from 1994-2015) using the standardized PASO (Primary Aldosteronism Surgical Outcome) criteria...
July 9, 2018: Hypertension
https://www.readbyqxmd.com/read/29967045/benefits-of-intensive-blood-pressure-treatment-in-patients-with-type-2-diabetes-mellitus-receiving-standard-but-not-intensive-glycemic-control
#12
Tetsuro Tsujimoto, Hiroshi Kajio
This study aimed to assess whether intensive blood pressure (BP) treatment has benefits in preventing cardiovascular events, including heart failure in patients with type 2 diabetes mellitus. Using the ACCORD BP trial (Action to Control Cardiovascular Risk in Diabetes Blood Pressure) data, hazard ratios for cardiovascular events with 95% confidence intervals were calculated using the Cox proportional hazard models to compare the time to the first cardiovascular event in patients receiving standard (n=2362) or intensive glycemic control (n=2371)...
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967044/are-the-american-heart-association-american-college-of-cardiology-high-blood-pressure-guidelines-fit-for-global-purpose-thoughts-from-the-international-society-of-hypertension
#13
Neil R Poulter, Rafael Castillo, Fadi J Charchar, Markus P Schlaich, Aletta E Schutte, Maciej Tomaszewski, Rhian M Touyz, Ji-Guang Wang
No abstract text is available yet for this article.
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967043/activity-tracking-s-newest-companion-pulse-wave-velocity
#14
EDITORIAL
Kathryn Sandberg, Stephen P Wright, Jason G Umans
No abstract text is available yet for this article.
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967042/can-blood-pressure-self-monitoring-improve-postpartum-management-of-pregnancy-associated-hypertension
#15
EDITORIAL
Jessica Sheehan Tangren
No abstract text is available yet for this article.
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967041/does-intensive-glucose-control-cancel-out-benefits-of-systolic-blood-pressure-target-120-mm-hg-in-patients-with-diabetes-mellitus-participating-in-accord
#16
EDITORIAL
Sverre E Kjeldsen, Ingrid Os, Peter M Nilsson
No abstract text is available yet for this article.
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967040/association-between-prepregnancy-cardiovascular-function-and-subsequent-preeclampsia-or-fetal-growth-restriction
#17
Fung L Foo, Amita A Mahendru, Giulia Masini, Abigail Fraser, Stefano Cacciatore, David A MacIntyre, Carmel M McEniery, Ian B Wilkinson, Phillip R Bennett, Christoph C Lees
Preeclampsia and fetal growth restriction during pregnancy are associated with increased risk of maternal cardiovascular disease later in life. It is unclear whether this association is causal or driven by similar antecedent risk factors. Clarification requires recruitment before conception which is methodologically difficult with high attrition rates and loss of outcome numbers to nonconception/miscarriage. Few prospective studies have, therefore, been adequately powered to address these questions. We recruited 530 healthy women (mean age: 35...
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967039/gene-centric-analysis-of-preeclampsia-identifies-maternal-association-at-plekhg1
#18
Kathryn J Gray, Vesela P Kovacheva, Hooman Mirzakhani, Andrew C Bjonnes, Berta Almoguera, Andrew T DeWan, Elizabeth W Triche, Audrey F Saftlas, Josephine Hoh, Dale L Bodian, Elisabeth Klein, Kathi C Huddleston, Sue Ann Ingles, Charles J Lockwood, Hakon Hakonarson, Thomas F McElrath, Jeffrey C Murray, Melissa L Wilson, Errol R Norwitz, S Ananth Karumanchi, Brian T Bateman, Brendan J Keating, Richa Saxena
The genetic susceptibility to preeclampsia, a pregnancy-specific complication with significant maternal and fetal morbidity, has been poorly characterized. To identify maternal genes associated with preeclampsia risk, we assembled 498 cases and 1864 controls of European ancestry from preeclampsia case-control collections in 5 different US sites (with additional matched population controls), genotyped samples on a cardiovascular gene-centric array composed of variants from ≈2000 genes selected based on prior genetic studies of cardiovascular and metabolic diseases and performed case-control genetic association analysis on 27 429 variants passing quality control...
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967038/genes-for-preeclampsia-an-opportunity-for-blood-pressure-genomics
#19
EDITORIAL
Georg Ehret
No abstract text is available yet for this article.
July 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29967037/self-management-of-postnatal-hypertension-the-snap-ht-trial
#20
Alexandra E Cairns, Katherine L Tucker, Paul Leeson, Lucy H Mackillop, Mauro Santos, Carmelo Velardo, Dario Salvi, Sam Mort, Jill Mollison, Lionel Tarassenko, Richard J McManus
Hypertension affects 1 in 10 pregnancies, often persisting postpartum, when antihypertensive requirements may vary substantially. This unmasked, randomized controlled trial evaluated the feasibility and effects on blood pressure (BP) of self-management of postpartum hypertension. Women with gestational hypertension or preeclampsia, requiring postnatal antihypertensive treatment, were randomized to self-management or usual care. Self-management entailed daily home BP monitoring and automated medication reduction via telemonitoring...
July 2, 2018: Hypertension
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