journal
MENU ▼
Read by QxMD icon Read
search

Hypertension

journal
https://www.readbyqxmd.com/read/28320856/sustained-reduction-of-blood-pressure-with-baroreceptor-activation-therapy-results-of-the-6-year-open-follow-up
#1
Peter W de Leeuw, John D Bisognano, George L Bakris, Mitra K Nadim, Hermann Haller, Abraham A Kroon
Baroreflex activation therapy is a novel technique for treating patients with resistant hypertension. Although short-term studies have demonstrated that it lowers blood pressure, long-term results have not yet been reported. The aim of the present study is to assess the long-term efficacy and safety of baroreflex activation therapy. Long-term follow-up data were analyzed from all patients who had been included in 1 of the 3 trials that focused on treatment-resistant hypertensive patients. Altogether, 383 patients were available for analysis: 143 of these had completed 5 years of follow-up and 48 patients had completed 6 years of follow-up...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320855/salt-sensitivity-of-angiogenesis-inhibition-induced-blood-pressure-rise-role-of-interstitial-sodium-accumulation
#2
Stephanie Lankhorst, David Severs, Lajos Markó, Natalia Rakova, Jens Titze, Dominik N Müller, A H Jan Danser, Anton H van den Meiracker
In response to salt loading, Na(+) and Cl(-) accumulate in the skin in excess of water, stimulating skin lymphangiogenesis via activation of the mononuclear phagocyte system cell-derived vascular endothelial growth factor-C-vascular endothelial growth factor type 3 receptor signaling pathway. Inhibition of this pathway results in salt-sensitive hypertension. Sunitinib is an antiangiogenic, anticancer agent that blocks all 3 vascular endothelial growth factor receptors and increases blood pressure. We explored the salt dependency of sunitinib-induced hypertension and whether impairment of skin lymphangiogenesis is an underlying mechanism...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320854/nonsteroidal-mineralocorticoid-receptor-antagonist-finerenone-protects-against-acute-kidney-injury-mediated-chronic-kidney-disease-role-of-oxidative-stress
#3
Lionel Lattenist, Sebastian M Lechner, Smail Messaoudi, Alan Le Mercier, Soumaya El Moghrabi, Sonia Prince, Norma A Bobadilla, Peter Kolkhof, Frédéric Jaisser, Jonatan Barrera-Chimal
Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown to be helpful against renal IR consequences; however, the potential benefit of novel nonsteroidal mineralocorticoid receptor antagonists such as finerenone has to be further explored. In this study, we evaluated the efficacy of finerenone to prevent the acute and chronic consequences of ischemic acute kidney injury. For the acute study (24 hours), 18 rats were divided into sham, bilateral renal ischemia of 25 minutes, and rats that received 3 doses of finerenone at 48, 24, and 1 hour before the ischemia...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320853/cardio-oncology-vascular-endothelial-growth-factor-inhibitors-salt-and-macrophages-a-complicated-interaction
#4
Javid Moslehi, Arvind K Pandey, Nirmanmoh Bhatia
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320852/reprogramming-innate-immune-signaling-in-cardiometabolic-disease
#5
REVIEW
Yaxing Zhang, Xiao-Jing Zhang, Pi-Xiao Wang, Peng Zhang, Hongliang Li
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320851/tmem16a-contributes-to-endothelial-dysfunction-by-facilitating-nox2-nadph-oxidase-derived-reactive-oxygen-species-generation-in-hypertension
#6
Ming-Ming Ma, Min Gao, Kai-Min Guo, Mi Wang, Xiang-Yu Li, Xue-Lin Zeng, Lu Sun, Xiao-Fei Lv, Yan-Hua Du, Guan-Lei Wang, Jia-Guo Zhou, Yong-Yuan Guan
Ca2(+)-activated Cl(-) channels play a crucial role in various physiological processes. However, the role of TMEM16A in vascular endothelial dysfunction during hypertension is unclear. In this study, we investigated the specific involvement of TMEM16A in regulating endothelial function and blood pressure and the underlying mechanism. Reverse transcription-polymerase chain reaction, Western blotting, coimmunoprecipitation, confocal imaging, patch-clamp recordings, and TMEM16A endothelial-specific transgenic and knockout mice were used...
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320850/hypertension-in-blacks-unanswered-questions-and-future-directions-for-the-jhs-jackson-heart-study
#7
REVIEW
Paul Muntner, Marwah Abdalla, Adolfo Correa, Michael Griswold, John E Hall, Daniel W Jones, George A Mensah, Mario Sims, Daichi Shimbo, Tanya M Spruill, Katherine L Tucker, Lawrence J Appel
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320849/role-of-perivascular-adipose-tissue-in-vascular-physiology-and-pathology
#8
REVIEW
Zhen Fang Huang Cao, Elina Stoffel, Paul Cohen
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320848/long-term-follow-up-of-baroreflex-activation-therapy-in-resistant-hypertension-another-piece-of-the-puzzle
#9
Sebastian Ewen, Michael Böhm, Felix Mahfoud
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28289182/continuum-of-renin-independent-aldosteronism-in-normotension
#10
Rene Baudrand, Francisco J Guarda, Carlos Fardella, Gregory Hundemer, Jenifer Brown, Gordon Williams, Anand Vaidya
Primary aldosteronism is a severe form of autonomous aldosteronism. Milder forms of autonomous and renin-independent aldosteronism may be common, even in normotension. We characterized aldosterone secretion in 210 normotensives who had suppressed plasma renin activity (<1.0 ng/mL per hour), completed an oral sodium suppression test, received an infusion of angiotensin II, and had measurements of blood pressure and renal plasma flow. Continuous associations between urinary aldosterone excretion rate, renin, and potassium handling were investigated...
March 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28289181/hypokalemia-and-pendrin-induction-by-aldosterone
#11
Ning Xu, Daigoro Hirohama, Kenichi Ishizawa, Wen Xiu Chang, Tatsuo Shimosawa, Toshiro Fujita, Shunya Uchida, Shigeru Shibata
Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na(+) channel, Na(+)-Cl(-) cotransporter, and Cl(-)/HCO3(-) exchanger pendrin are the major mediators of Na-Cl transport in the aldosterone-sensitive distal nephron. Existing evidence also suggests that plasma K(+) concentration affects renal Na-Cl handling. In this study, we posited that hypokalemia modulates the effects of aldosterone on pendrin in hyperaldosteronism. Chronic aldosterone infusion in mice increased pendrin levels at the plasma membrane, and correcting hypokalemia in this model almost completely blocked pendrin upregulation...
March 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28289180/beneficial-effects-of-apelin-on-vascular-function-in-patients-with-central-obesity
#12
Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro
Patients with central obesity have impaired insulin-stimulated vasodilation and increased ET-1 (endothelin 1) vasoconstriction, which may contribute to insulin resistance and vascular damage. Apelin enhances insulin sensitivity and glucose disposal but also acts as a nitric oxide (NO)-dependent vasodilator and a counter-regulator of AT1 (angiotensin [Ang] II type 1) receptor-induced vasoconstriction. We, therefore, examined the effects of exogenous (Pyr(1))apelin on NO-mediated vasodilation and Ang II- or ET-1-dependent vasoconstrictor tone in obese patients...
March 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28289179/primary-aldosteronism-or-not-primary-aldosteronism-is-this-now-the-question-in-normotension
#13
EDITORIAL
Ellen Marie Freel
No abstract text is available yet for this article.
March 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28264923/blood-pressure-in-healthy-humans-is-regulated-by-neuronal-no-synthase
#14
Husain Shabeeh, Sitara Khan, Benyu Jiang, Sally Brett, Narbeh Melikian, Barbara Casadei, Philip J Chowienczyk, Ajay M Shah
NO is physiologically generated by endothelial and neuronal NO synthase (nNOS) isoforms. Although nNOS was first identified in brain, it is expressed in other tissues, including perivascular nerves, cardiac and skeletal muscle. Increasing experimental evidence suggests that nNOS has important effects on cardiovascular function, but its composite effects on systemic hemodynamics in humans are unknown. We undertook the first human study to assess the physiological effects of systemic nNOS inhibition on basal hemodynamics...
March 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28264921/nitric-oxide-and-cardiovascular-regulation-beyond-the-endothelium
#15
EDITORIAL
Paul J Fadel
No abstract text is available yet for this article.
March 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28264918/mean-heart-rate-level-does-not-affect-all-heart-rate-variability-indices
#16
LETTER
Luiz Eduardo Virgilio Silva, Helio Cesar Salgado, Rubens Fazan
No abstract text is available yet for this article.
March 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28264917/muscle-attenuation-is-associated-with-newly-developed-hypertension-in-men-of-african-ancestry
#17
Qian Zhao, Joseph M Zmuda, Allison L Kuipers, Clareann H Bunker, Alan L Patrick, Ada O Youk, Iva Miljkovic
Increased ectopic adipose tissue infiltration in skeletal muscle is associated with insulin resistance and diabetes mellitus. We evaluated whether change in skeletal muscle adiposity predicts subsequent development of hypertension in men of African ancestry, a population sample understudied in previous studies. In the Tobago Health Study, a prospective longitudinal study among men of African ancestry (age range 40-91 years), calf intermuscular adipose tissue, and skeletal muscle attenuation were measured with computed tomography...
March 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28264916/continuing-or-temporarily-stopping-prestroke-antihypertensive-medication-in-acute-stroke-an-individual-patient-data-meta-analysis
#18
Lisa J Woodhouse, Lisa Manning, John F Potter, Eivind Berge, Nikola Sprigg, Joanna Wardlaw, Kennedy R Lees, Philip M Bath, Thompson G Robinson
Over 50% of patients are already taking blood pressure-lowering therapy on hospital admission for acute stroke. An individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus temporarily stopping preexisting antihypertensive medication in acute stroke. Key databases were searched for trials against the following inclusion criteria: randomized design; stroke onset ≤48 hours; investigating the effect of continuation versus stopping prestroke antihypertensive medication; and follow-up of ≥2 weeks...
March 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28242717/chronic-deep-brain-stimulation-decreases-blood-pressure-and-sympathetic-nerve-activity-in-a-drug-and-device-resistant-hypertensive-patient
#19
Erin L O'Callaghan, Emma C Hart, Hugh Sims-Williams, Shazia Javed, Amy E Burchell, Mark Papouchado, Jens Tank, Karsten Heusser, Jens Jordan, Jan Menne, Hermann Haller, Angus K Nightingale, Julian F R Paton, Nikunj K Patel
No abstract text is available yet for this article.
February 27, 2017: Hypertension
https://www.readbyqxmd.com/read/28242716/hypertension-and-its-complications-in-a-young-man-with-autoimmune-disease
#20
Eve Miller-Hodges, Anna F Dominiczak, Garry L R Jennings, Suzanne Oparil, Daniel C Batlle, Fernando Elijovich, Jan N Basile, Cheryl L Laffer, Anna Oliveras, Neeraj Dhaun
No abstract text is available yet for this article.
February 27, 2017: Hypertension
journal
journal
27681
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"