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Hypertension

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https://www.readbyqxmd.com/read/28533333/pgc-1%C3%AE-peroxisome-proliferator-activated-receptor-%C3%AE-coactivator-1-%C3%AE-overexpression-in-coronary-artery-disease-recruits-no-and-hydrogen-peroxide-during-flow-mediated-dilation-and-protects-against-increased-intraluminal-pressure
#1
Andrew O Kadlec, Dawid S Chabowski, Karima Ait-Aissa, Joseph C Hockenberry, Mary F Otterson, Matthew J Durand, Julie K Freed, Andreas M Beyer, David D Gutterman
Blood flow through healthy human vessels releases NO to produce vasodilation, whereas in patients with coronary artery disease (CAD), the mediator of dilation transitions to mitochondria-derived hydrogen peroxide (mtH2O2). Excessive mtH2O2 production contributes to a proatherosclerotic vascular milieu. Loss of PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α) is implicated in the pathogenesis of CAD. We hypothesized that PGC-1α suppresses mtH2O2 production to reestablish NO-mediated dilation in isolated vessels from patients with CAD...
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28533332/of-mice-and-renin
#2
EDITORIAL
Michael Bader
No abstract text is available yet for this article.
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28533331/chronic-stimulation-of-renin-cells-leads-to-vascular-pathology
#3
Masafumi Oka, Silvia Medrano, Maria Luisa S Sequeira-Lόpez, R Ariel Gómez
Experimental or spontaneous genomic mutations of the renin-angiotensin system or its pharmacological inhibition in early life leads to renal abnormalities, including poorly developed renal medulla, papillary atrophy, hydronephrosis, inability to concentrate the urine, polyuria, polydipsia, renal failure, and anemia. At the core of such complex phenotype is the presence of unique vascular abnormalities: the renal arterioles do not branch or elongate properly and they have disorganized, concentric hypertrophy...
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28533330/race-and-sex-differences-of-long-term-blood-pressure-profiles-from-childhood-and-adult-hypertension-the-bogalusa-heart-study
#4
Wei Shen, Tao Zhang, Shengxu Li, Huijie Zhang, Bo Xi, Hongbing Shen, Camilo Fernandez, Lydia Bazzano, Jiang He, Wei Chen
This study aims to characterize longitudinal blood pressure (BP) trajectories from childhood in black-white and sex groups and examine the association between childhood level-independent trajectories of BP and adult hypertension. The longitudinal cohort consisted of 2732 adults who had body mass index and BP measured 4 to 15 times from childhood (4-19 years) to adulthood (20-51 years). Model-estimated levels and linear slopes of BP and body mass index at childhood age points were calculated at 1-year intervals using the growth curve parameters and their first derivatives, respectively...
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28533329/pregnancy-outcome-after-first-trimester-use-of-methyldopa-a-prospective-cohort-study
#5
Maria Hoeltzenbein, Evelin Beck, Anne-Katrin Fietz, Juliane Wernicke, Sandra Zinke, Angela Kayser, Stephanie Padberg, Corinna Weber-Schoendorfer, Reinhard Meister, Christof Schaefer
Published experience on first trimester exposure to methyldopa is still limited, although it is recommended as first-line treatment for hypertensive disorders in pregnancy in most countries. The primary aim of this prospective observational cohort study was to analyze the rate of major birth defects and spontaneous abortions in women with methyldopa therapy for chronic hypertension. Outcomes of 261 pregnancies with first trimester exposure to methyldopa and 526 comparison pregnancies without chronic hypertension reported to the German Embryotox pharmacovigilance institute were evaluated...
May 22, 2017: Hypertension
https://www.readbyqxmd.com/read/28507174/elevated-adenosine-induces-placental-dna-hypomethylation-independent-of-a2b-receptor-signaling-in-preeclampsia
#6
Aji Huang, Hongyu Wu, Takayuki Iriyama, Yujin Zhang, Kaiqi Sun, Anren Song, Hong Liu, Zhangzhe Peng, Lili Tang, Minjung Lee, Yun Huang, Xin Ni, Rodney E Kellems, Yang Xia
Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global placental DNA hypomethylation is observed in patients with preeclampsia and is linked to altered gene expression and disease development. However, the molecular basis underlying placental epigenetic changes in preeclampsia remains unclear. Using 2 independent experimental models of preeclampsia, adenosine deaminase-deficient mice and a pathogenic autoantibody-induced mouse model of preeclampsia, we demonstrate that elevated placental adenosine not only induces hallmark features of preeclampsia but also causes placental DNA hypomethylation...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28507173/resistant-hypertension-an-update-of-experimental-and-clinical-findings
#7
REVIEW
Anping Cai, David A Calhoun
No abstract text is available yet for this article.
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28507172/hemodynamic-and-mechanical-properties-of-the-proximal-aorta-in-young-and-middle-aged-adults-with-isolated-systolic-hypertension-the-dallas-heart-study
#8
Yuichiro Yano, Ian J Neeland, Colby Ayers, Ronald Peshock, Jarett D Berry, Donald M Lloyd-Jones, Philip Greenland, Gary F Mitchell, Wanpen Vongpatanasin
The aim of this study was to assess characteristic impedance (Zc) of the proximal aorta in young and middle-aged individuals with isolated systolic hypertension (ISH). Zc is an index of aortic stiffness relative to aortic size. In the Dallas Heart Study, 2001 untreated participants 18 to 64 years of age (mean age: 42.3 years; 44% black race) were divided into the following groups based on office blood pressure (BP) measurements: (1) optimal BP (systolic BP [SBP] <120 mm Hg and diastolic BP [DBP] <80 mm Hg; n=837); (2) prehypertension (SBP 120-139 mm Hg and DBP 80-89 mm Hg; n=821); (3) ISH (SBP ≥140 mm Hg and DBP <90 mm Hg; n=121); (4) isolated diastolic hypertension (SBP <140 mm Hg and DBP ≥90 mm Hg; n=44); and (5) systolic-diastolic hypertension (SBP ≥140 mm Hg and DBP ≥90 mm Hg; n=178)...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28507171/first-in-man-demonstration-of-direct-endothelin-mediated-natriuresis-and-diuresis
#9
Robert W Hunter, Rebecca Moorhouse, Tariq E Farrah, Iain M MacIntyre, Takae Asai, Peter J Gallacher, Debbie Kerr, Vanessa Melville, Alicja Czopek, Emma E Morrison, Jess R Ivy, James W Dear, Matthew A Bailey, Jane Goddard, David J Webb, Neeraj Dhaun
Endothelin (ET) receptor antagonists are potentially novel therapeutic agents in chronic kidney disease and resistant hypertension, but their use is complicated by sodium and water retention. In animal studies, this side effect arises from ETB receptor blockade in the renal tubule. Previous attempts to determine whether this mechanism operates in humans have been confounded by the hemodynamic consequences of ET receptor stimulation/blockade. We aimed to determine the effects of ET signaling on salt transport in the human nephron by administering subpressor doses of the ET-1 precursor, big ET-1...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28507170/hypertension-causing-mutation-in-peroxisome-proliferator-activated-receptor-%C3%AE-impairs-nuclear-export-of-nuclear-factor-%C3%AE%C2%BAb-p65-in-vascular-smooth-muscle
#10
Masashi Mukohda, Ko-Ting Lu, Deng-Fu Guo, Jing Wu, Henry L Keen, Xuebo Liu, Pimonrat Ketsawatsomkron, Madeliene Stump, Kamal Rahmouni, Frederick W Quelle, Curt D Sigmund
Selective expression of dominant negative (DN) peroxisome proliferator-activated receptor γ (PPARγ) in vascular smooth muscle cells (SMC) results in hypertension, atherosclerosis, and increased nuclear factor-κB (NF-κB) target gene expression. Mesenteric SMC were cultured from mice designed to conditionally express wild-type (WT) or DN-PPARγ in response to Cre recombinase to determine how SMC PPARγ regulates expression of NF-κB target inflammatory genes. SMC-specific overexpression of WT-PPARγ or agonist-induced activation of endogenous PPARγ blunted tumor necrosis factor α (TNF-α)-induced NF-κB target gene expression and activity of an NF-κB-responsive promoter...
May 15, 2017: Hypertension
https://www.readbyqxmd.com/read/28483919/ambulatory-pulse-wave-velocity-is-a-stronger-predictor-of-cardiovascular-events-and-all-cause-mortality-than-office-and-ambulatory-blood-pressure-in-hemodialysis-patients
#11
Pantelis A Sarafidis, Charalampos Loutradis, Antonios Karpetas, Georgios Tzanis, Alexia Piperidou, Georgios Koutroumpas, Vasilios Raptis, Christos Syrgkanis, Vasilios Liakopoulos, Georgios Efstratiadis, Gérard London, Carmine Zoccali
Arterial stiffness and augmentation of aortic blood pressure (BP) measured in office are known cardiovascular risk factors in hemodialysis patients. This study examines the prognostic significance of ambulatory brachial BP, central BP, pulse wave velocity (PWV), and heart rate-adjusted augmentation index [AIx(75)] in this population. A total of 170 hemodialysis patients underwent 48-hour ambulatory monitoring with Mobil-O-Graph-NG during a standard interdialytic interval and followed-up for 28.1±11.2 months...
May 8, 2017: Hypertension
https://www.readbyqxmd.com/read/28483918/hypertension-in-women-recent-advances-and-lingering-questions
#12
REVIEW
Amier Ahmad, Suzanne Oparil
No abstract text is available yet for this article.
May 8, 2017: Hypertension
https://www.readbyqxmd.com/read/28483917/ambulatory-pulse-wave-velocity-monitoring-a-step-forward
#13
EDITORIAL
Theodore G Papaioannou, Dimitrios A Vrachatis, Dimitris Tousoulis
No abstract text is available yet for this article.
May 8, 2017: Hypertension
https://www.readbyqxmd.com/read/28483916/prevalence-treatment-and-control-rates-of-conventional-and-ambulatory-hypertension-across-10-populations-in-3-continents
#14
Jesus D Melgarejo, Gladys E Maestre, Lutgarde Thijs, Kei Asayama, José Boggia, Edoardo Casiglia, Tine W Hansen, Yutaka Imai, Lotte Jacobs, Jørgen Jeppesen, Kalina Kawecka-Jaszcz, Tatiana Kuznetsova, Yan Li, Sofia Malyutina, Yuri Nikitin, Takayoshi Ohkubo, Katarzyna Stolarz-Skrzypek, Ji-Guang Wang, Jan A Staessen
Hypertension is a major global health problem, but prevalence rates vary widely among regions. To determine prevalence, treatment, and control rates of hypertension, we measured conventional blood pressure (BP) and 24-hour ambulatory BP in 6546 subjects, aged 40 to 79 years, recruited from 10 community-dwelling cohorts on 3 continents. We determined how between-cohort differences in risk factors and socioeconomic factors influence hypertension rates. The overall prevalence was 49.3% (range between cohorts, 40...
May 8, 2017: Hypertension
https://www.readbyqxmd.com/read/28373587/case-of-chronic-indolent-pheochromocytoma-that-caused-medically-controlled-hypertension-but-treatment-resistant-diabetes-mellitus
#15
HyunJung Lee, Anna F Dominiczak, Garry L R Jennings, Eun Joo Cho, Hae-Young Lee
No abstract text is available yet for this article.
April 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28373585/discontinuation-of-therapy-in-hypertension-research-value-ethics-risk-and-role-in-renal-denervation-trials
#16
Fernando Elijovich, Cheryl L Laffer
No abstract text is available yet for this article.
April 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28320853/cardio-oncology-vascular-endothelial-growth-factor-inhibitors-salt-and-macrophages-a-complicated-interaction
#17
Javid Moslehi, Arvind K Pandey, Nirmanmoh Bhatia
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320852/reprogramming-innate-immune-signaling-in-cardiometabolic-disease
#18
REVIEW
Yaxing Zhang, Xiao-Jing Zhang, Pi-Xiao Wang, Peng Zhang, Hongliang Li
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320850/hypertension-in-blacks-unanswered-questions-and-future-directions-for-the-jhs-jackson-heart-study
#19
REVIEW
Paul Muntner, Marwah Abdalla, Adolfo Correa, Michael Griswold, John E Hall, Daniel W Jones, George A Mensah, Mario Sims, Daichi Shimbo, Tanya M Spruill, Katherine L Tucker, Lawrence J Appel
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28320849/role-of-perivascular-adipose-tissue-in-vascular-physiology-and-pathology
#20
REVIEW
Zhen Fang Huang Cao, Elina Stoffel, Paul Cohen
No abstract text is available yet for this article.
March 20, 2017: Hypertension
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