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Hypertension

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https://www.readbyqxmd.com/read/28223477/znf307-zinc-finger-protein-307-acts-as-a-negative-regulator-of-pressure-overload-induced-cardiac-hypertrophy
#1
Chang-Jiang Yu, Chen Liang, Yu-Xia Li, Qing-Qing Hu, Wei-Wan Zheng, Na Niu, Xu Yang, Zi-Rui Wang, Xiao-Di Yu, Bao-Long Zhang, Bin-Lin Song, Zhi-Ren Zhang
Pathological cardiac hypertrophy is a key risk factor for heart failure. We found that the protein expression levels of the ZNF307 (zinc finger protein 307) were significantly increased in heart samples from both human patients with dilated cardiomyopathy and mice subjected to aortic banding. Therefore, we aimed to elucidate the role of ZNF307 in the development of cardiac hypertrophy and to explore the signal transduction events that mediate the effect of ZNF307 on cardiac hypertrophy, using cardiac-specific ZNF307 transgenic (ZNF307-TG) mice and ZNF307 global knockout (ZNF307-KO) mice...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223476/offspring-cardiovascular-disease-in-preeclampsia-nature-versus-nurture
#2
EDITORIAL
Alice M Wang, S Ananth Karumanchi
No abstract text is available yet for this article.
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223475/reduced-first-phase-ejection-fraction-and-sustained-myocardial-wall-stress-in-hypertensive-patients-with-diastolic-dysfunction-a-manifestation-of-impaired-shortening-deactivation-that-links-systolic-to-diastolic-dysfunction-and-preserves-systolic-ejection-fraction
#3
Haotian Gu, Ye Li, Henry Fok, John Simpson, Jonathan C Kentish, Ajay M Shah, Philip J Chowienczyk
Impaired shortening deactivation of cardiac myocytes could sustain myocardial contraction, preserving ejection fraction at the expense of diastolic dysfunction. We examined the relationship between first-phase ejection fraction (EF1), the fraction of left ventricular volume ejected from the start of systole to the time of the first peak in left ventricular pressure (corresponding to the time of maximal ventricular shortening) to the duration of myocardial contraction and diastolic function in patients with hypertension (n=163), and varying degrees of diastolic dysfunction...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223474/can-pediatric-hypertension-criteria-be-simplified-a-prediction-analysis-of-subclinical-cardiovascular-outcomes-from-the-bogalusa-heart-study
#4
Bo Xi, Tao Zhang, Shengxu Li, Emily Harville, Lydia Bazzano, Jiang He, Wei Chen
Prehypertension and hypertension in childhood are defined by sex-, age-, and height-specific 90th (or ≥120/80 mm Hg) and 95th percentiles of blood pressure, respectively, by the 2004 Fourth Report. However, these cutoffs are complex and cumbersome for use. This study assessed the performance of a simplified blood pressure definition to predict adult hypertension and subclinical cardiovascular disease. The cohort consisted of 1225 adults (530 men; aged 26.3-47.7 years) from the Bogalusa Heart Study with 27...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223473/simplified-thresholds-for-pediatric-pre-hypertension-one-approach-to-improve-recognition-and-outcome
#5
EDITORIAL
Karel Allegaert, Elena Levtchenko
No abstract text is available yet for this article.
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223472/overexpression-of-sarcoendoplasmic-reticulum-calcium-atpase-2a-promotes-cardiac-sympathetic-neurotransmission-via-abnormal-endoplasmic-reticulum-and-mitochondria-ca-2-regulation
#6
Julia Shanks, Neil Herring, Errin Johnson, Kun Liu, Dan Li, David J Paterson
Reduced cardiomyocyte excitation-contraction coupling and downregulation of the SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gene therapy expressed under a similar promiscuous cytomegalovirus promoter could also affect the cardiac sympathetic neural axis and promote sympathoexcitation. Stellate neurons were isolated from 90 to 120 g male, Sprague-Dawley, Wistar Kyoto, and spontaneously hypertensive rats...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223471/adiposity-and-blood-pressure-in-110-000-mexican-adults
#7
Louisa Gnatiuc, Jesus Alegre-Díaz, Jim Halsey, William G Herrington, Malaquías López-Cervantes, Sarah Lewington, Rory Collins, Roberto Tapia-Conyer, Richard Peto, Jonathan R Emberson, Pablo Kuri-Morales
Previous studies have reached differing conclusions about the importance of general versus central markers of adiposity to blood pressure, leading to suggestions that population-specific adiposity thresholds may be needed. We examined the relevance of adiposity to blood pressure among 111 911 men and women who, when recruited into the Mexico City Prospective Study, were aged 35 to 89 years, had no chronic disease, and were not taking antihypertensives. Linear regression was used to estimate the effects on systolic and diastolic blood pressure of 2 markers of general adiposity (body mass index and height-adjusted weight) and 4 markers of central adiposity (waist circumference, hip circumference, waist:hip ratio, and waist:height ratio), adjusted for relevant confounders...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223470/deciphering-systolic-diastolic-coupling-in-the-intact-heart
#8
EDITORIAL
Julio A Chirinos
No abstract text is available yet for this article.
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223469/maternal-gestational-hypertension-induced-sensitization-of-angiotensin-ii-hypertension-is-reversed-by-renal-denervation-or-angiotensin-converting-enzyme-inhibition-in-rat-offspring
#9
Baojian Xue, Haifeng Yin, Fang Guo, Terry G Beltz, Robert L Thunhorst, Alan Kim Johnson
Numerous findings demonstrate that there is a strong association between maternal health during pregnancy and cardiovascular disease in adult offspring. The purpose of the present study was to test whether maternal gestational hypertension modulates brain renin-angiotensin-aldosterone system (RAAS) and proinflammatory cytokines that sensitizes angiotensin II-elicited hypertensive response in adult offspring. In addition, the role of renal nerves and the RAAS in the sensitization process was investigated. Reverse transcription polymerase chain reaction analyses of structures of the lamina terminalis and paraventricular nucleus indicated upregulation of mRNA expression of several RAAS components and proinflammatory cytokines in 10-week-old male offspring of hypertensive dams...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223468/high-ambulatory-arterial-stiffness-index-is-an-independent-risk-factor-for-rapid-age-related-glomerular-filtration-rate-decline-in-the-general-middle-aged-population
#10
Bjørn Odvar Eriksen, Vidar Tor Nyborg Stefansson, Trond Geir Jenssen, Ulla Dorte Mathisen, Jørgen Schei, Marit Dahl Solbu, Tom Wilsgaard, Toralf Melsom
Arterial stiffness is a risk factor for cardiovascular and chronic kidney disease. However, the role of arterial stiffness as a predictor of the age-related glomerular filtration rate (GFR) decline in the general population remains unresolved because of difficulty in measuring GFR with sufficient precision in epidemiological studies. The ambulatory arterial stiffness index (AASI) is a proposed indicator of arterial stiffness easily calculated from ambulatory blood pressure. We investigated whether AASI could predict GFR decline measured as iohexol clearance in the general population...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223467/hypertension-in-pregnancy-and-offspring-cardiovascular-risk-in-young-adulthood-prospective-and-sibling-studies-in-the-hunt-study-nord-tr%C3%A3-ndelag-health-study-in-norway
#11
Ingvild V Alsnes, Lars J Vatten, Abigail Fraser, Johan Håkon Bjørngaard, Janet Rich-Edwards, Pål R Romundstad, Bjørn O Åsvold
Women with hypertensive disorders in pregnancy are at increased lifetime risk for cardiovascular disease. We examined the offspring's cardiovascular risk profile in young adulthood and their siblings' cardiovascular risk profile. From the HUNT study (Nord-Trøndelag Health Study) in Norway, 15 778 participants (mean age: 29 years), including 210 sibling groups, were linked to information from the Medical Birth Registry of Norway. Blood pressure, anthropometry, serum lipids, and C-reactive protein were assessed...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28193712/genomics-and-precision-medicine-for-clinicians-and-scientists-in-hypertension
#12
Anna Dominiczak, Christian Delles, Sandosh Padmanabhan
No abstract text is available yet for this article.
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193711/blood-pressure-variability-predicts-clinical-outcomes-now-what
#13
EDITORIAL
Jeff Whittle
No abstract text is available yet for this article.
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193710/potential-for-mirnas-as-biomarkers-and-therapeutic-targets-in-preeclampsia
#14
EDITORIAL
Liliya M Yamaleyeva, Sarah H Lindsey
No abstract text is available yet for this article.
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193709/testosterone-represses-estrogen-signaling-by-upregulating-mir-22-a-mechanism-for-imbalanced-steroid-hormone-production-in-preeclampsia
#15
Xuan Shao, Yanlei Liu, Ming Liu, Yongqing Wang, Liying Yan, Hao Wang, Liyang Ma, Yu-Xia Li, Yangyu Zhao, Yan-Ling Wang
Preeclampsia, a multisystem syndrome occurring during mid- to late gestation in humans, is a leading cause of maternal and perinatal morbidity and mortality. Patients usually present with high circulating testosterone and reduced estradiol production, but the mechanisms remain unclear. Revealing the mechanism that modulating the imbalance of testosterone and estradiol in preeclampsia is of great value in understanding the cause of the disease. The placenta is the predominant source of steroid hormone production during gestation, and we observed markedly increased 17β-HSD3 (17β-hydroxysteroid dehydrogenase 3) levels and downregulated aromatase expression, the key enzymes responsible for synthesis of testosterone and estradiol, respectively, in preeclamptic placentas compared with controls...
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193708/case-of-primary-aldosteronism-with-discordant-hormonal-and-computed-tomographic-findings
#16
Laurence Amar, Yehonatan Sharabi, Gian Paolo Rossi, Emmanuelle Vidal-Petiot, Anna F Dominiczak, Paolo Mulatero, Anne-Laure Faucon, Neeraj Dhaun, Rhian M Touyz, Mohammed Barigou, Aurelien Lorthioir
No abstract text is available yet for this article.
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193707/arterial-pressure-heart-rate-and-cerebral-hemodynamics-across-the-adult-life-span
#17
Chang-Yang Xing, Takashi Tarumi, Rutger L Meijers, Marcel Turner, Justin Repshas, Li Xiong, Kan Ding, Wanpen Vongpatanasin, Li-Jun Yuan, Rong Zhang
Age-related alterations in systemic and cerebral hemodynamics are not well understood. The purpose of this study is to characterize age-related alterations in beat-to-beat oscillations in arterial blood pressure (BP), heart rate (HR), cerebral blood flow (CBF), cardiac baroreflex sensitivity, and dynamic cerebral autoregulation across the adult life span. We studied 136 healthy adults aged 21 to 80 years (60% women). Beat-to-beat BP, HR, and CBF velocity were measured at rest and during sit-stand maneuvers to mimic effects of postural changes on BP and CBF...
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193706/small-vessels-big-role-renal-microcirculation-and-progression-of-renal-injury
#18
Alejandro R Chade
No abstract text is available yet for this article.
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28193705/outcome-driven-thresholds-for-increased-home-blood-pressure-variability
#19
Eeva P Juhanoja, Teemu J Niiranen, Jouni K Johansson, Pauli J Puukka, Lutgarde Thijs, Kei Asayama, Ville L Langén, Atsushi Hozawa, Lucas S Aparicio, Takayoshi Ohkubo, Ichiro Tsuji, Yutaka Imai, George S Stergiou, Antti M Jula, Jan A Staessen
Increased blood pressure (BP) variability predicts cardiovascular disease, but lack of operational thresholds limits its use in clinical practice. Our aim was to define outcome-driven thresholds for increased day-to-day home BP variability. We studied a population-based sample of 6238 individuals (mean age 60.0±12.9, 56.4% women) from Japan, Greece, and Finland. All participants self-measured their home BP on ≥3 days. We defined home BP variability as the coefficient of variation of the first morning BPs on 3 to 7 days...
February 13, 2017: Hypertension
https://www.readbyqxmd.com/read/28167687/prediction-of-preeclampsia-using-the-soluble-fms-like-tyrosine-kinase-1-to-placental-growth-factor-ratio-a-prospective-cohort-study-of-unselected-nulliparous-women
#20
Ulla Sovio, Francesca Gaccioli, Emma Cook, Martin Hund, D Stephen Charnock-Jones, Gordon C S Smith
We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 platform at ≈20, ≈28, and ≈36 weeks of gestational age (wkGA). Screen positive was defined as an sFlt-1:PlGF ratio >38, but higher thresholds were also studied...
February 6, 2017: Hypertension
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