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Hypertension

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https://www.readbyqxmd.com/read/29038204/do-we-need-a-patient-centered-target-for-systolic-blood-pressure-in-hypertensive-patients-with-type-2-diabetes-mellitus
#1
Eric Yuk Fai Wan, Esther Yee Tak Yu, Colman Siu Cheung Fung, Weng Yee Chin, Daniel Yee Tak Fong, Anca Ka Chun Chan, Cindy Lo Kuen Lam
The current trend on diabetes mellitus management advocates replacing the paradigm from a uniform to an individualized patient-centered systolic blood pressure (SBP), but there is no consensus on the achieved treatment goals of SBP level. The study aimed at evaluating the association between SBP and the risk of cardiovascular diseases (CVD) and all-cause mortality for diabetic patients to identify patient-centered treatment targets. A retrospective study was conducted on 95 086 Chinese adult primary care patients with type 2 diabetes mellitus and hypertension...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29038203/effect-of-continuous-positive-airway-pressure-weight-loss-or-continuous-positive-airway-pressure-plus-weight-loss-on-central-hemodynamics-and-arterial-stiffness
#2
Snigdha Jain, Indira Gurubhagavatula, Raymond Townsend, Samuel T Kuna, Karen Teff, Thomas A Wadden, Jesse Chittams, Alexandra L Hanlon, Greg Maislin, Hassam Saif, Preston Broderick, Zeshan Ahmad, Allan I Pack, Julio A Chirinos
Obesity and obstructive sleep apnea tend to coexist. Little is known about the effects of obstructive sleep apnea, obesity, or their treatment on central aortic pressures and large artery stiffness. We randomized 139 adults with obesity (body mass index >30 kg/m(2)) and moderate-to-severe obstructive sleep apnea to (1) continuous positive airway pressure (CPAP) therapy (n=45), (2) weight loss (WL) therapy (n=48), or (3) combined CPAP and WL (n=46) for 24 weeks. We assessed the effect of these interventions on central pressures and carotid-femoral pulse wave velocity (a measure of large artery stiffness), measured with arterial tonometry...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29038202/brain-regional-blood-flow-and-working-memory-performance-predict-change-in-blood-pressure-over-2-years
#3
J Richard Jennings, Alicia F Heim, Lei K Sheu, Matthew F Muldoon, Christopher Ryan, H Michael Gach, Claudiu Schirda, Peter J Gianaros
Hypertension is a presumptive risk factor for premature cognitive decline. However, lowering blood pressure (BP) does not uniformly reverse cognitive decline, suggesting that high BP per se may not cause cognitive decline. We hypothesized that essential hypertension has initial effects on the brain that, over time, manifest as cognitive dysfunction in conjunction with both brain vascular abnormalities and systemic BP elevation. Accordingly, we tested whether neuropsychological function and brain blood flow responses to cognitive challenges among prehypertensive individuals would predict subsequent progression of BP...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29038201/kinin-b1-receptor-promotes-neurogenic-hypertension-through-activation-of-centrally-mediated-mechanisms
#4
Srinivas Sriramula, Eric Lazartigues
Hypertension is associated with increased activity of the kallikrein-kinin system. Kinin B1 receptor (B1R) activation leads to vasoconstriction and inflammation. Despite evidence supporting a role for the B1R in blood pressure regulation, the mechanisms by which B1R could alter autonomic function and participate in the pathogenesis of hypertension remain unidentified. We sought to explore whether B1R-mediated inflammation contributes to hypertension and investigate the molecular mechanisms involved. In this study, we tested the hypothesis that activation of B1R in the brain is involved in the pathogenesis of hypertension, using the deoxycorticosterone acetate-salt model of neurogenic hypertension in wild-type and B1R knockout mice...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29038200/renal-denervation-after-the-spyral-htn-off-med-trial-putting-a-complex-study-into-context
#5
EDITORIAL
Markus P Schlaich, Murray D Esler
No abstract text is available yet for this article.
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29038199/does-the-treatment-of-obstructive-sleep-apnea-and-obesity-improve-pulsatile-hemodynamics
#6
EDITORIAL
Thomas Weber, Siegfried Wassertheurer
No abstract text is available yet for this article.
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/28993452/macrolides-blunt-aldosterone-biosynthesis-a-proof-of-concept-study-in-kcnj5-mutated-adenoma-cells-ex-vivo
#7
Brasilina Caroccia, Selene Prisco, Teresa Maria Seccia, Maria Piazza, Giuseppe Maiolino, Gian Paolo Rossi
Aldosterone-producing adenoma (APA), a major subtype of primary hyperaldosteronism, the main curable cause of human endocrine hypertension, involves somatic mutations in the potassium channel Kir3.4 (KCNJ5) in 30% to 70% of cases, typically the more florid phenotypes. Because KCNJ5 mutated channels were reported to be specifically sensitive to inhibition by macrolide antibiotics, which concentration dependently blunts aldosterone production in HAC15 transfected with the G151R and L168R mutated channel, we herein tested the effect of clarithromycin on aldosterone synthesis and secretion in a pure population of aldosterone-secreting cells obtained by immunoseparation (CD56(+) cells) from APA tissues with/without the 2 most common KCNJ5 mutations...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28993450/blood-pressure-genetic-risk-score-predicts-blood-pressure-responses-to-dietary-sodium-and-potassium-the-gensalt-study-genetic-epidemiology-network-of-salt-sensitivity
#8
Jovia L Nierenberg, Changwei Li, Jiang He, Dongfeng Gu, Jichun Chen, Xiangfeng Lu, Jianxin Li, Xigui Wu, C Charles Gu, James E Hixson, Dabeeru C Rao, Tanika N Kelly
We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of BP among participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). The GenSalt study was conducted among 1906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/d), 7-day high-sodium (307.8 mmol sodium/d), and 7-day high-sodium plus potassium (60 mmol potassium/d) intervention...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28993449/visit-to-visit-blood-pressure-variability-in-young-adulthood-and-hippocampal-volume-and-integrity-at-middle-age-the-cardia-study-coronary-artery-risk-development-in-young-adults
#9
Yuichiro Yano, Jared P Reis, Deborah A Levine, R Nick Bryan, Anthony J Viera, Daichi Shimbo, Yacob G Tedla, Norrina B Allen, Pamela J Schreiner, Michael P Bancks, Stephen Sidney, Mark J Pletcher, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones, Lenore J Launer
The aims of this study are to assess the relationships of visit-to-visit blood pressure (BP) variability in young adulthood to hippocampal volume and integrity at middle age. We used data over 8 examinations spanning 25 years collected in the CARDIA study (Coronary Artery Risk Development in Young Adults) of black and white adults (age, 18-30 years) started in 1985 to 1986. Visit-to-visit BP variability was defined as by SDBP and average real variability (ARVBP, defined as the absolute differences of BP between successive BP measurements)...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28993448/aberrant-splicing-induced-by-dysregulated-rbfox2-produces-enhanced-function-of-cav1-2-calcium-channel-and-vascular-myogenic-tone-in-hypertension
#10
Yingying Zhou, Jia Fan, Huayuan Zhu, Li Ji, Wenyong Fan, Isha Kapoor, Yue Wang, Yuan Wang, Guoqing Zhu, Juejin Wang
Calcium influx from activated voltage-gated calcium channel CaV1.2 in vascular smooth muscle cells is indispensable for maintaining myogenic tone and blood pressure. The function of CaV1.2 channel can be optimized by alternative splicing, one of post-transcriptional modification mechanisms. The splicing factor Rbfox2 is known to regulate the CaV1.2 pre-mRNA alternative splicing events during neuronal development. However, Rbfox2's roles in modulating the key function of vascular CaV1.2 channel and in the pathogenesis of hypertension remain elusive...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28974571/endothelial-mineralocorticoid-receptor-mediates-parenchymal-arteriole-and-posterior-cerebral-artery-remodeling-during-angiotensin-ii-induced-hypertension
#11
Janice M Diaz-Otero, Courtney Fisher, Kelsey Downs, M Elizabeth Moss, Iris Z Jaffe, William F Jackson, Anne M Dorrance
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain...
October 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28974566/cardiovascular-structure-and-function-in-children-with-middle-aortic-syndrome-and-renal-artery-stenosis
#12
Rawan K Rumman, Cameron Slorach, Wei Hui, Mina Matsuda-Abedini, Valerie Langlois, Seetha Radhakrishnan, Armando J Lorenzo, Joao Amaral, Luc Mertens, Rulan S Parekh
Middle aortic syndrome (MAS) is a narrowing of the abdominal aorta, often in conjunction with renal artery stenosis (RAS). Structure and function of the cardiovascular system are not well understood. In a prospective cross-sectional study, 35 children with MAS or RAS or both (MAS/RAS) were compared with 140 age-, sex-, and body surface area-matched healthy children. Vascular assessment included carotid intima-media thickness and carotid distensibility using B-mode ultrasound and central and peripheral pulse wave velocities using applanation tonometry...
October 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28974565/apelin-is-a-negative-regulator-of-angiotensin-ii-mediated-adverse-myocardial-remodeling-and-dysfunction
#13
Zhen-Zhou Zhang, Wang Wang, Hai-Yan Jin, Xueyi Chen, Yu-Wen Cheng, Ying-Le Xu, Bei Song, Josef M Penninger, Gavin Y Oudit, Jiu-Chang Zhong
The apelin pathway has emerged as a critical regulator of cardiovascular homeostasis and disease. However, the exact role of pyr1-apelin-13 in angiotensin (Ang) II-mediated heart disease remains unclear. We used apelin-deficient (APLN(-)(/y)) and apolipoprotein E knockout mice to evaluate the regulatory roles of pyr1-apelin-13. The 1-year aged APLN(-)(/y) mice developed myocardial hypertrophy and dysfunction with reduced angiotensin-converting enzyme 2 levels. Ang II infusion (1.5 mg kg(-)(1) d(-)(1)) for 4 weeks potentiated oxidative stress, pathological hypertrophy, and myocardial fibrosis in young APLN(-)(/y) hearts resulting in exacerbation of cardiac dysfunction...
October 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28947617/treating-visit-to-visit-blood-pressure-variability-to-improve-prognosis-is-amlodipine-the-drug-of-choice
#14
REVIEW
Anastasios Kollias, George S Stergiou, Konstantinos G Kyriakoulis, Grzegorz Bilo, Gianfranco Parati
No abstract text is available yet for this article.
September 25, 2017: Hypertension
https://www.readbyqxmd.com/read/28947616/review-of-markers-of-zona-glomerulosa-and-aldosterone-producing-adenoma-cells
#15
REVIEW
Teresa M Seccia, Brasilina Caroccia, Elise P Gomez-Sanchez, Paul-Emmanuel Vanderriele, Celso E Gomez-Sanchez, Gian Paolo Rossi
No abstract text is available yet for this article.
September 25, 2017: Hypertension
https://www.readbyqxmd.com/read/28947614/establishing-funding-priorities-for-hypertension-research-a-modest-proposal
#16
EDITORIAL
Theodore A Kotchen
No abstract text is available yet for this article.
September 25, 2017: Hypertension
https://www.readbyqxmd.com/read/28923900/diagnosing-and-treating-hypertensive-disorders-of-pregnancy-the-answer-may-now-be-less-baff-ling
#17
EDITORIAL
Christopher T Chan, Maggie Lieu, Christopher G Sobey, Grant R Drummond, Antony Vinh
No abstract text is available yet for this article.
September 18, 2017: Hypertension
https://www.readbyqxmd.com/read/28893897/recent-advances-atrial-fibrillation-and-hypertension
#18
REVIEW
Mikhail S Dzeshka, Alena Shantsila, Eduard Shantsila, Gregory Y H Lip
No abstract text is available yet for this article.
September 11, 2017: Hypertension
https://www.readbyqxmd.com/read/28874465/recent-advances-mechanisms-and-subclinical-consequences-of-aortic-stiffness
#19
REVIEW
Gary L Pierce
No abstract text is available yet for this article.
September 5, 2017: Hypertension
https://www.readbyqxmd.com/read/28847891/cardiovascular-risk-associated-with-white-coat-hypertension-pro-side-of-the-argument
#20
Giuseppe Mancia, Michele Bombelli, Cesare Cuspidi, Rita Facchetti, Guido Grassi
No abstract text is available yet for this article.
August 28, 2017: Hypertension
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